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Conserved domains on  [gi|446492099|ref|WP_000569953|]
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MULTISPECIES: ABC transporter permease [Escherichia]

Protein Classification

ABC transporter permease( domain architecture ID 10794130)

ABC transporter permease is part of the histidine ABC transporter complex, and is also a part of a lysine/arginine/ornithine transporter

Gene Ontology:  GO:0055052|GO:0022857
PubMed:  26517919

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15069 PRK15069
histidine ABC transporter permease HisM;
1-234 6.06e-163

histidine ABC transporter permease HisM;


:

Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 449.50  E-value: 6.06e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYS 80
Cdd:PRK15069   1 MIEILQEYWKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  81 GMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIAL 160
Cdd:PRK15069  81 GMYSLEIVRGTDLLDAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446492099 161 PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKP 234
Cdd:PRK15069 161 PAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAHLKP 234
 
Name Accession Description Interval E-value
PRK15069 PRK15069
histidine ABC transporter permease HisM;
1-234 6.06e-163

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 449.50  E-value: 6.06e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYS 80
Cdd:PRK15069   1 MIEILQEYWKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  81 GMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIAL 160
Cdd:PRK15069  81 GMYSLEIVRGTDLLDAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446492099 161 PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKP 234
Cdd:PRK15069 161 PAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAHLKP 234
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 2-236 8.22e-107

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 307.41  E-value: 8.22e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   2 IEILHEYWkPLLWTdgyrftGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSG 81
Cdd:COG4160    3 LDLLFEYL-PLLLS------GLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  82 MYTLEIVKGTeFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALP 161
Cdd:COG4160   76 LGQFEWVRES-WLWPLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALP 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446492099 162 AYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSS 236
Cdd:COG4160  155 AYSNEVILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRHLRPRR 229
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 20-227 3.78e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 98.39  E-value: 3.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVkgtefLNAFFR 99
Cdd:TIGR03003  14 IEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIR-----LPALVA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  100 SglnctVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAFT 179
Cdd:TIGR03003  89 G-----VLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 446492099  180 ATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:TIGR03003 164 ITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 25-218 5.36e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 5.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  25 ITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMytleivkGTEFLNAFFRSGLNC 104
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLF-------GVLLGWGILPGLGLP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099 105 TVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAFTATVPD 184
Cdd:cd06261   76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446492099 185 LLKIARDINAATYQPFTAFGIAAVLYLIISYVLI 218
Cdd:cd06261  156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 37-224 9.52e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 47.68  E-value: 9.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   37 GGVLALFLAIGRvssNKYIQFPIWLFTYIFRGTPLYVQLLVFYsgmytleivkgTEFLNAFFRSGLNCTVLALTLNTCAY 116
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLV-----------VIAILSILGHGILPAIILALLGWAGY 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  117 TTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVI-LMLHSTALAFTATVPDL-LKIARDINA 194
Cdd:pfam00528  67 ARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGgALGGAVLLEFLGSWPGLgLLLIEAILG 146

                         170       180       190
                  ....*....|....*....|....*....|
gi 446492099  195 ATYQPFTAFGIAAVLYLIISYVLISLFRRA 224
Cdd:pfam00528 147 YDYPEIQGPVLAAALILLLLNLLVDILQRL 176
 
Name Accession Description Interval E-value
PRK15069 PRK15069
histidine ABC transporter permease HisM;
1-234 6.06e-163

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 449.50  E-value: 6.06e-163
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYS 80
Cdd:PRK15069   1 MIEILQEYWKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  81 GMYTLEIVKGTEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIAL 160
Cdd:PRK15069  81 GMYSLEIVRGTDLLDAFFRSGLNCTILAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRAL 160

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446492099 161 PAYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKP 234
Cdd:PRK15069 161 PAYSNEVILMLHATTLAFTATVPDILKIARDINSATYQPFQAFGIAAVLYLIISFVLISLFRRAERRWLAHLKP 234
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 2-236 8.22e-107

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 307.41  E-value: 8.22e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   2 IEILHEYWkPLLWTdgyrftGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSG 81
Cdd:COG4160    3 LDLLFEYL-PLLLS------GLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPLLVQLFLIYYG 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  82 MYTLEIVKGTeFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALP 161
Cdd:COG4160   76 LGQFEWVRES-WLWPLLRDPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALP 154

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446492099 162 AYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVKPSS 236
Cdd:COG4160  155 AYSNEVILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERRLLRHLRPRR 229
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-228 4.37e-62

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 193.37  E-value: 4.37e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   2 IEILHEYWKPLLwtdgyrfTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSG 81
Cdd:COG0765    5 FSVLLDYLPLLL-------EGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  82 MYTLEIVkgtefLNAFFRSglnctVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALP 161
Cdd:COG0765   78 LPLLGID-----LSPFVAA-----VIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILP 147

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446492099 162 AYSNEVILMLHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRW 228
Cdd:COG0765  148 PLGNEFISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRL 214
artM PRK11122
arginine ABC transporter permease ArtM;
22-229 1.16e-41

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 141.25  E-value: 1.16e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  22 GVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVKGTEFLNAFFRSG 101
Cdd:PRK11122  11 GLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPLLVQIFLIYYGPGQFPWLQEYPWLWHLLSQP 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099 102 LNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHcIILPSALRIALPAYSNEVILMLHSTALAFTAT 181
Cdd:PRK11122  91 WLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFKSTSLAYTIT 169

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446492099 182 VPDLLKIARDINAATYQpFTAFGIAAVLYLIISYVLISLFRRAEKRWL 229
Cdd:PRK11122 170 LMDVMGYSQLLYGRTYD-VMVFGAAGIIYLVVNGLLTLLMRLIERKAL 216
PRK15100 PRK15100
cystine ABC transporter permease;
22-231 3.72e-30

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 111.76  E-value: 3.72e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  22 GVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLeivkGTEFlnaffrSG 101
Cdd:PRK15100  18 GAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQLFMIYYGLPQF----GIEL------DP 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099 102 LNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAFTAT 181
Cdd:PRK15100  88 IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKDTSLAATIQ 167

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446492099 182 VPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQH 231
Cdd:PRK15100 168 VPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQLNRQ 217
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
25-227 5.35e-30

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 111.69  E-value: 5.35e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  25 ITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTP-----LYV-----QLLVFYSGMYTLEI----VKG 90
Cdd:PRK11123  13 MTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPeilvvLFIyfgssQLLLTLSDGFTLNLgfvqIPV 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  91 TEFLNAFFRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILM 170
Cdd:PRK11123  93 QMDIENFEVSPFLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLGNQWLVL 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446492099 171 LHSTALAFTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:PRK11123 173 LKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELR 229
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 20-227 3.78e-25

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 98.39  E-value: 3.78e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVkgtefLNAFFR 99
Cdd:TIGR03003  14 IEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDIGIR-----LPALVA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  100 SglnctVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAFT 179
Cdd:TIGR03003  89 G-----VLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLVAMFKETPVLSA 163

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 446492099  180 ATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:TIGR03003 164 ITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
20-233 3.39e-23

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 93.70  E-value: 3.39e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTP-LYVQLLVFYSGMYTLEIVKGTEFLNAFF 98
Cdd:PRK15135  10 LQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPdLVLMLLIFYGLQIALNSVTEALGVGQID 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  99 RSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAF 178
Cdd:PRK15135  90 IDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALVS 169

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446492099 179 TATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKRWLQHVK 233
Cdd:PRK15135 170 LLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERRYSVGVK 224
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 20-227 1.73e-19

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 83.57  E-value: 1.73e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLeivkgtefLNAFFR 99
Cdd:PRK09494  16 LEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMA--------FNDLRI 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099 100 SGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAFT 179
Cdd:PRK09494  88 DPFTAAVVTIMINSGAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQWIISIKDTSLFIV 167

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*...
gi 446492099 180 ATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:PRK09494 168 IGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 25-218 5.36e-17

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 76.16  E-value: 5.36e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  25 ITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMytleivkGTEFLNAFFRSGLNC 104
Cdd:cd06261    3 NTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLF-------GVLLGWGILPGLGLP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099 105 TVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALAFTATVPD 184
Cdd:cd06261   76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                        170       180       190
                 ....*....|....*....|....*....|....
gi 446492099 185 LLKIARDINAATYQPFTAFGIAAVLYLIISYVLI 218
Cdd:cd06261  156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLS 189
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 20-123 1.42e-12

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 61.78  E-value: 1.42e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   20 FTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYSGMYTLEIVkgteflnaffR 99
Cdd:TIGR01726   6 LKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLIGIR----------L 75

                          90       100
                  ....*....|....*....|....
gi 446492099  100 SGLNCTVLALTLNTCAYTTEIFAG 123
Cdd:TIGR01726  76 SPLTAAVIALTLFYGAYLAEIFRG 99
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
18-227 7.65e-12

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 62.54  E-value: 7.65e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  18 YRFTGVAITLWLLILSVVIGGVLALFLAIGRVSSNKYIQFPIWLFTYIFRGTPLYVQLLVFYsgMYTLEIVKGTEFLNAF 97
Cdd:PRK15107  15 YLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFY--LIVPGFLQNVLGLSPK 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  98 FRSGLNCTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVILMLHSTALA 177
Cdd:PRK15107  93 TDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLV 172

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446492099 178 FTATVPDLLKIARDINAATYQPFTAFGIAAVLYLIISYVLISLFRRAEKR 227
Cdd:PRK15107 173 YVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKR 222
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 37-224 9.52e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 47.68  E-value: 9.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   37 GGVLALFLAIGRvssNKYIQFPIWLFTYIFRGTPLYVQLLVFYsgmytleivkgTEFLNAFFRSGLNCTVLALTLNTCAY 116
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALPSFVLAILLV-----------VIAILSILGHGILPAIILALLGWAGY 66

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  117 TTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSALRIALPAYSNEVI-LMLHSTALAFTATVPDL-LKIARDINA 194
Cdd:pfam00528  67 ARLIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGgALGGAVLLEFLGSWPGLgLLLIEAILG 146

                         170       180       190
                  ....*....|....*....|....*....|
gi 446492099  195 ATYQPFTAFGIAAVLYLIISYVLISLFRRA 224
Cdd:pfam00528 147 YDYPEIQGPVLAAALILLLLNLLVDILQRL 176
PhnE TIGR01097
phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound ...
 1-156 2.73e-05

phosphonate ABC transporter, permease protein PhnE; Phosphonates are a class of compound analogous to organic phosphates, but in which the C-O-P linkage is replaced by a direct, stable C-P bond. Some bacteria can utilize phosphonates as a source of phosphorus. This family consists of permease proteins of known or predicted phosphonate ABC transporters. Often this protein is found as a duplicated pair, occasionally as a fused pair. Certain "second" copies score in between the trusted and noise cutoff and should be considered true hits (by context). [Transport and binding proteins, Anions]


Pssm-ID: 273441 [Multi-domain]  Cd Length: 250  Bit Score: 44.07  E-value: 2.73e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099    1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAI---GRVSSNKYIQFPIWLFTYIFRGTPlyvqllv 77
Cdd:TIGR01097  38 MADLLGRMFPPDWSYLPRILKALLETLAMAILGTVLAAVLAVPLALlaaRNITPSPWLYGLARLLLNFLRAIP------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   78 fysgmytlEIVKGTEFLNAFfrsGLN--CTVLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSA 155
Cdd:TIGR01097 111 --------ELVWALIFVAAV---GLGpfAGVLALAFHTVGFLGKLFAEAIEEVDPGPVEALRATGASKLQVIRYGVLPQV 179


                  .
gi 446492099  156 L 156
Cdd:TIGR01097 180 L 180
PhnE COG3639
ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport ...
 1-156 2.36e-04

ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 442856 [Multi-domain]  Cd Length: 244  Bit Score: 41.22  E-value: 2.36e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099   1 MIEILHEYWKPLLWTDGYRFTGVAITLWLLILSVVIGGVLALFLAI---GRVSSNKYIQFPIWLFTYIFRGTPlyvqllv 77
Cdd:COG3639   31 LADFLSRFFPPDWSYLPDLLSALLETLAIALLGTLLGAVLALPLAFlaaRNLAPNPWVRLLARRLLNVLRAIP------- 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  78 fysgmytlEIVKGTEFLNAFfrsGLNCT--VLALTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSA 155
Cdd:COG3639  104 --------ELVWALIFVAAV---GLGPFagVLALAIHTIGFLGKLFAEAIEEIDPGPVEALRATGASRLQVIRYGVLPQV 172


                 .
gi 446492099 156 L 156
Cdd:COG3639  173 L 173
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 13-156 2.99e-03

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 37.82  E-value: 2.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446492099  13 LWTDGYRFTGVAITLWLLILSVVIGGVLALFLAIGrVSSNKYIQFPIWLFTYIFRGTPL--YVQLLVFYSGMYTLEIVkG 90
Cdd:COG0600   53 LLASGELWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPlaLAPLLILWFGIGEASKI-F 130

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446492099  91 TEFLNAFFrsglnctvlALTLNTcaytteifAGAIRSVPHGEIEAARAYGFSTFKMYHCIILPSAL 156
Cdd:COG0600  131 VIFLGAFF---------PILLNT--------AAGVRSVDPELLELARSLGASRWQILRKVVLPAAL 179
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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