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Conserved domains on  [gi|446489679|ref|WP_000567533|]
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MULTISPECIES: HPr family phosphocarrier protein [Gammaproteobacteria]

Protein Classification

HPr family phosphocarrier protein( domain architecture ID 10788234)

HPr family phosphocarrier protein is part of a phosphoenolpyruvate-dependent phosphotransferase (PTS)-like system that catalyzes the phosphorylation of incoming substrates with their concomitant translocation across the cell membrane

CATH:  3.30.1340.10
Gene Ontology:  GO:0008982
PubMed:  12405346
SCOP:  4001693
TCDB:  8.A.8

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 3.91e-34

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


:

Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 112.12  E-value: 3.91e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQAL 80
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                ....*...
gi 446489679 81 FAAKFYEA 88
Cdd:COG1925  81 IESGFGEE 88
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 3.91e-34

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 112.12  E-value: 3.91e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQAL 80
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                ....*...
gi 446489679 81 FAAKFYEA 88
Cdd:COG1925  81 IESGFGEE 88
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 4.48e-29

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 99.00  E-value: 4.48e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446489679   5 TVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQALFA 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 5.24e-22

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 81.16  E-value: 5.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679   1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQAL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 446489679  81 FA 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-79 1.50e-13

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 59.80  E-value: 1.50e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQA 79
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEALAA 79
 
Name Accession Description Interval E-value
PtsH COG1925
HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport ...
 1-88 3.91e-34

HPr or related phosphotransfer protein [Signal transduction mechanisms, Carbohydrate transport and metabolism];


Pssm-ID: 441528 [Multi-domain]  Cd Length: 88  Bit Score: 112.12  E-value: 3.91e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQAL 80
Cdd:COG1925   1 MLEREVTIVNKLGLHARPAAKLVQLASKFDSEITVEKGGKEVNAKSIMGLMSLGAKKGDEVTITAEGPDAEEALDALAAL 80


                ....*...
gi 446489679 81 FAAKFYEA 88
Cdd:COG1925  81 IESGFGEE 88
PTS-HPr pfam00381
PTS HPr component phosphorylation site;
5-82 4.48e-29

PTS HPr component phosphorylation site;


Pssm-ID: 459792 [Multi-domain]  Cd Length: 79  Bit Score: 99.00  E-value: 4.48e-29
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446489679   5 TVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQALFA 82
Cdd:pfam00381  2 TVTITNPLGLHARPAALLVQLASKFDSDITLEKGGKKVNAKSIMGLMSLGAKQGDEITISAEGEDEEEALEALAALLE 79
PTS_HPr_family TIGR01003
Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains ...
 1-82 5.24e-22

Phosphotransferase System HPr (HPr) Family; The HPr family are bacterial proteins (or domains of proteins) which function in phosphoryl transfer system (PTS) systems. They include energy-coupling components which catalyze sugar uptake via a group translocation mechanism. The functions of most of these proteins are not known, but they presumably function in PTS-related regulatory capacities. All seed members are stand-alone HPr proteins, although the model also recognizes HPr domains of PTS fusion proteins. This family includes the related NPr protein. [Signal transduction, PTS]


Pssm-ID: 273389 [Multi-domain]  Cd Length: 82  Bit Score: 81.16  E-value: 5.24e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679   1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQAL 80
Cdd:TIGR01003  1 MLSKEVTIINKVGLHARPAAILVKLASGFDSEITLTKNGKEVNAKSIMGIMMLGAGQGTEVTVSADGEDEAEALEALAKL 80


                 ..
gi 446489679  81 FA 82
Cdd:TIGR01003 81 FE 82
PRK13782 PRK13782
HPr family phosphocarrier protein;
1-79 1.50e-13

HPr family phosphocarrier protein;


Pssm-ID: 172320 [Multi-domain]  Cd Length: 82  Bit Score: 59.80  E-value: 1.50e-13
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQA 79
Cdd:PRK13782  1 MVQKRVEVSLKTGLQARPAALFVQEANRFHADIFIEKDGKKVNAKSIMGLMSLAIGTGSMITIITEGSDEEEALEALAA 79
PRK10897 PRK10897
PTS phosphocarrier protein NPr;
5-87 8.18e-13

PTS phosphocarrier protein NPr;


Pssm-ID: 182819 [Multi-domain]  Cd Length: 90  Bit Score: 58.30  E-value: 8.18e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679  5 TVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHL-VDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQALFAA 83
Cdd:PRK10897  6 TVEIKNKLGMHARPAMKLFELVQGFDAEVLLRNDEGTeAEANSVIALLMLDSAKGRQIEVEATGPQEEEALAAVIALFNS 85


                ....
gi 446489679 84 KFYE 87
Cdd:PRK10897 86 GFDE 89
PRK11377 PRK11377
dihydroxyacetone kinase subunit M; Provisional
 5-88 1.20e-10

dihydroxyacetone kinase subunit M; Provisional


Pssm-ID: 183108 [Multi-domain]  Cd Length: 473  Bit Score: 55.91  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679   5 TVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQALFAAK 84
Cdd:PRK11377 159 SVVIKNRNGLHVRPASRLVYTLSTFNADMLLEKNGKCVTPESLNQIALLQVRYNDTLRLIAKGPEAEEALIAFRQLAEDN 238


                 ....
gi 446489679  85 FYEA 88
Cdd:PRK11377 239 FGET 242
PRK13780 PRK13780
phosphocarrier protein HPr; Provisional
 1-77 1.84e-10

phosphocarrier protein HPr; Provisional


Pssm-ID: 237503 [Multi-domain]  Cd Length: 88  Bit Score: 52.01  E-value: 1.84e-10
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEV 77
Cdd:PRK13780  1 MASKDFHITAETGIHARPATLLVQTASKFDSDITLEYNGKSVNLKSIMGVMSLGVGQGADITISAEGADAADAIAAI 77
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 5-83 8.38e-10

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 53.34  E-value: 8.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679   5 TVDVINKLGLHARASGKLIEVTTKFRSSI---QIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQALF 81
Cdd:PRK13779 294 TFTIRNEHGLHARPSANLVNEVKKFTAKItveNLTRGSAPVSAKSLMKIVALGVTQGHRLRFVAEGEDAQQAIEALAKAI 373


                 ..
gi 446489679  82 AA 83
Cdd:PRK13779 374 AE 375
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 2-83 1.98e-09

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 52.18  E-value: 1.98e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679   2 IDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGD---HLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQ 78
Cdd:PRK13779 415 VEGVFVIKNEHGLHARPSAVLVNEVKKYNASVAVQNLDrntQLVSAKSLMKIVALGVVKGHRLRFVATGEEAQQAIDGIG 494


                 ....*
gi 446489679  79 ALFAA 83
Cdd:PRK13779 495 AAIAA 499
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
8-83 1.22e-08

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 49.95  E-value: 1.22e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446489679   8 VINKLGLHARASGKLIEVTTKFRSSIQIGKGD---HLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQALFAA 83
Cdd:PRK11109 292 IRNEHGLHARPGAMLVNTIKQFNSEITVTNLDgtgKPANGRSLMKVVALGVKKGHRLRFTAQGEDAEQALKAIGEAIAA 370
PRK10850 PRK10850
phosphocarrier protein Hpr;
1-82 5.78e-08

phosphocarrier protein Hpr;


Pssm-ID: 182777 [Multi-domain]  Cd Length: 85  Bit Score: 45.89  E-value: 5.78e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446489679  1 MIDTTVDVINKLGLHARASGKLIEVTTKFRSSIQIGKGDHLVDAKNIMSLLMLGAGKGTTLRLVIDGTDEEQALNEVQAL 80
Cdd:PRK10850  1 MFQQEVTITAPNGLHTRPAAQFVKEAKGFTSEITVTSNGKSASAKSLFKLQTLGLTQGTVVTISAEGEDEQKAVEHLVKL 80


                ..
gi 446489679 81 FA 82
Cdd:PRK10850 81 MA 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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