|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
1-393 |
0e+00 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 718.19 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 1 MHNSPTVTSAKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGD 80
Cdd:PRK15011 1 MHNSPAVSSAKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 81 RKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGP 160
Cdd:PRK15011 81 RKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 161 PLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRDTLLLFVICTLMWGSNSLYIINMP 240
Cdd:PRK15011 161 PLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMRKELPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIINMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 241 LFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIG 320
Cdd:PRK15011 241 LFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIG 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446474149 321 ILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRIKDV 393
Cdd:PRK15011 321 ILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSLAGIVAEIWNYHAVFWFALVMIIATLFCLLRIKDV 393
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
19-392 |
0e+00 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 544.37 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTL 98
Cdd:TIGR00899 1 AFLLVAFLTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQGDRKGLILFCCLLAALACLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 99 FAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:TIGR00899 81 FAWNRNYFLLLVLGVLLSSFASTANPQLFALAREHADRTGREAVMFSSVMRAQISLAWVIGPPLAFWLALGFGFTVMFLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 179 AAVAFIVCGVMVWLFLPSMQKELPLATGTVEAP-RRNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVM 257
Cdd:TIGR00899 161 AALAFVLCGVLVWLFLPSYPRGAPGALTRLEVRgLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDKLAGLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 258 MGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQ 337
Cdd:TIGR00899 241 MGTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQDLMPGR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446474149 338 AGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRIKD 392
Cdd:TIGR00899 321 AGAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-388 |
2.20e-142 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 409.63 E-value: 2.20e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLF 99
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 100 AWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADK-TGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:cd17471 81 AFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 179 AAVAFIVCGVMVWLFLPSMQKELPLAT-GTVEAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVM 257
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQKATpASSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 258 MGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQ 337
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQ 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446474149 338 AGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd17471 321 PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLLL 371
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
19-356 |
2.59e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 105.06 E-value: 2.59e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSiFLTDEVHARPAMVGFFFTGSAvIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTL 98
Cdd:COG2814 14 ALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYL-LGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 99 FAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:COG2814 92 CALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 179 AAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMM 258
Cdd:COG2814 170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLL 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 259 GTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQA 338
Cdd:COG2814 250 ALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEA 329
|
330
....*....|....*....
gi 446474149 339 -GSATTLYTNTSRVGWIIA 356
Cdd:COG2814 330 rGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-391 |
8.43e-22 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 95.72 E-value: 8.43e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTdEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGdRKSLIVFCCLLGVLACTLF 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 100 AWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSA 179
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAM--GIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 180 AVAFIVCGVMVWLFLP------SMQKELPLATGTVEAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKL 253
Cdd:cd17325 157 AALALLALVLALLLLPeprpppNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 254 AGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDL 333
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446474149 334 MP-GQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRIK 391
Cdd:cd17325 317 VPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-356 |
3.21e-21 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 93.64 E-value: 3.21e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKsLIVFCCLLGVLACTLF 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRR-VLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 100 AWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSA 179
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 180 AVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRN------RRDTLLLFVICTLMWGSNSLYIINMPLFiINELHLPEKL 253
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 254 AGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMA---HSPVILLGLQLLNAIFIGILGGIGMLYF 330
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLsltLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*..
gi 446474149 331 QDLMP-GQAGSATTLYTNTSRVGWIIA 356
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-388 |
1.30e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.49 E-value: 1.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTDeVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGdRKSLIVFCCLLGVLACTLF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 100 AWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAM--GFSFTVMYL 177
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRAL--GLLQAFGSVGGILGPLLGGILASslGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 178 SAAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPR--------RNRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHL 249
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSvlkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 250 PEKLAGVMMGTAAGLEIPTMLIAGYFAKR-LGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGML 328
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446474149 329 YFQDLMP-GQAGSATTLYTNTSRVGWIIAGSVAGIV-AEIWNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd06174 317 LIAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGFLlAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-388 |
5.69e-19 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 87.60 E-value: 5.69e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 15 LTSTAFLIVAFLTGIAGALQTptlsifLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGdRKSLIVFCCLLGVL 94
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLLPD------IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIE-RRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 95 ACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSFTV 174
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI--GLVFSGLTLGLVLGRPLGGLLGQLLGWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 175 MYLSAAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRD--TLLLFVICTLMWGSNSLYIINMPLFIINELHLPEK 252
Cdd:cd17324 155 AFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNprLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 253 LAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQD 332
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446474149 333 LMPGQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd17324 315 LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-391 |
1.79e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 83.80 E-value: 1.79e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSD----KRGDRKSLIVFCCLLGVL 94
Cdd:COG2211 14 AYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 95 ACTLFAWNRN-----YFVLLFVGVFLSSFGSTA-NPQMFALArehADKTG--REAVMFSSFLRAQVSLAWVIGPPLAYAL 166
Cdd:COG2211 94 SFVLLFTAPDlsptgKLIYALVTYLLLGLAYTLvNIPYSALG---AELTPdyEERTRLSSWRFAFAGLGGLLASVLPPPL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 167 AMGFS------FTVMYLSAAVAFIVCGVMVWLFL---PSMQKELPLATGTVEAPRRNRrDTLLLFVICTLMWGSNSLYII 237
Cdd:COG2211 171 VAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTkerPVPEEEKVSLKESLKALLKNR-PFLLLLLAYLLFFLALALVAA 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 238 NMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMA--HSPVILLGLQLLN 315
Cdd:COG2211 250 LLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLgpGNLWLLLVLAALA 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 316 AIFIGILGGIGMLYFQDLMP--------GQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHA---------------V 372
Cdd:COG2211 330 GIGLGAILVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirllF 409
|
410
....*....|....*....
gi 446474149 373 FWFAMVMIIATLFCLLRIK 391
Cdd:COG2211 410 FLLPAVLLLLAALLLLFYP 428
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-390 |
2.04e-16 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 79.97 E-value: 2.04e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSIFLTDeVHARPAMVGFFFTGSAVIGILVSqFLAGRSDKRGDRKSLIVFC----CLLGVL 94
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFS-PFAGVLADRFDRRRLLILAdllrALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 95 ACTLFAWNRNYFVLLFVGVFLSSFGSTA-NPQMFALAREHADKtgREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFT 173
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFfGPARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLGPG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 174 VMYLSAAVAFIVCGVMVWL-----FLPSMQKELPLATGTVEAPRRNRRDTLLLFVICT--LMWGSNSLYIINMPLFIINE 246
Cdd:cd06173 159 GAFAINALSFLLSALLLLFirrppPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLAlaLFALLGGALTVLLPLLAKEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 247 LHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIG 326
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446474149 327 MLYFQDLMPGQ-AGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRI 390
Cdd:cd06173 319 NTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-390 |
1.43e-15 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 77.27 E-value: 1.43e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSqFLAGR-SDKRGdRKSLIVFCCLLGVLACTLF 99
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVAS-LIGGRlADRFG-RKPVMLAGLLLRALGFALL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 100 AWNRNyFVLLFVGVFLSSFGSTA-NPQMFALAREHADKTGREAVmfSSFLRAQVSLAWVIGPPLAYALAMgFSFTVMYLS 178
Cdd:cd17329 83 GFAHS-PWLFAIALVLTGFGGGLfEPASEAMIADVTTPENRTRA--FSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 179 AAVAFIVCGVMVWLFLP--SMQKELPLATGTVEAPRRNRRDT-----LLLFVICTLMWGSNSLYIinmPLFIINELHLPE 251
Cdd:cd17329 159 AAVLFLLAALVLLFLLPetRPKRRAAEKTEILRGYKIVLRDRafllfLLASFLISLIYFQLESTL---PVYVVEILGLGE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 252 KLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQ 331
Cdd:cd17329 236 SLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVA 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 332 DLMP-GQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRI 390
Cdd:cd17329 316 ALAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-391 |
3.38e-14 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 73.37 E-value: 3.38e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIF---LTDEVHARPAMVGFFFTgSAVIGILVSQFLAGR-SDKRGDRKsLIVFCCLLGVLAC 96
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAappLQADLGLSAAQLGLLAS-AFFLGYALGQIPAGLlADRFGRRR-VLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 97 TLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKtgREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMY 176
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPP--KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 177 LSAAVAFIVCGVMVwlflpsmqkelplatgtveaprrnrrdTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGV 256
Cdd:COG2271 168 LILGLPGLLLALLR---------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 257 MMGTAAGLEIPTMLIAGYFAKRLGKR--FLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLM 334
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446474149 335 PGQ-AGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRIK 391
Cdd:COG2271 301 PKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-391 |
8.46e-14 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 72.19 E-value: 8.46e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 15 LTSTAFLIVAFLTGIAGALQTptlsiFLTDEVHARPAMVGFFFTGSAvIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVL 94
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIP-----ALKDAFGLSDAQAGLLLFAFF-LGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 95 ACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGReavMFSSFLRAQVSLAWVIGPPL-AYALAMGFSFT 173
Cdd:COG0738 86 GLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAA---SRLNLLHAFFSLGALLGPLLgGLLILLGLSLS 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 174 VMYLSAAVAFIVCGVMVWLF---LPSMQKELPLATGTVEAPRR--NRRDTLLLFVICTLMWGSNSLYIINMPLFIINELH 248
Cdd:COG0738 163 WHLPYLILAVLLLLLALLFLrskLPEIEEEEEEAAGSAASLKSllKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 249 LPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGML 328
Cdd:COG0738 243 LSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFS 322
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446474149 329 YFQDLMPGQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRIK 391
Cdd:COG0738 323 LALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
51-388 |
1.03e-13 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 71.82 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 51 AMVGFFFTGSAVIGILVSQFLAGRSDKRGdRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVgVFLSSFGSTA-NPQMFAL 129
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKP-RRYLLPLGPLLTGLGLSLLGFAPNYWLLLLL-VALAGIGSAAfHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 130 AREHAdktGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMQKELPLATGTVE 209
Cdd:cd17478 109 ASQAA---GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 210 APRRNRRDTLLLFVICTLMWgSNSLYIINMPLFI---INELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMR 286
Cdd:cd17478 186 ARSTLKGVWRALLLLLIIVF-LRSWVLSSLTTFLpfyLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVII 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 287 VAAVGGVCFYAGMLMAHSPVILLGLQLLNAiFIGILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSVAGIVAEI 366
Cdd:cd17478 265 ASLLLAAPFLLLFLLTPGIWSYILLVLAGF-LLFASFPVTVVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGALADA 343
|
330 340
....*....|....*....|..
gi 446474149 367 WNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd17478 344 FGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-194 |
1.77e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.07 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGiLVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTL 98
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS-ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 99 FAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM--GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 446474149 179 AAVAFIVCGVMVWLFL 194
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-385 |
1.32e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 68.37 E-value: 1.32e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIFLTDEV--HARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVfcCLLGVLAC-T 97
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLL--SLAGSAVSyV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 98 LFAWNRNyFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYL 177
Cdd:cd17330 80 LLGLSRN-LWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAF--GIISAAFGLGFILGPALGGFLSTPYGYALPFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 178 SAAVAFIVCGVMVWLFLPSMqkelplatgtveaprrnrrdtLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVM 257
Cdd:cd17330 157 VAAALALLNLVLVLFFLPPL---------------------RRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLL 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 258 MGTAAGLEIPT-MLIAGYFAKRLGKRFLMRVAAVGGVCFYAGM-LMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMP 335
Cdd:cd17330 216 LALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLpFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPS 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446474149 336 GQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLF 385
Cdd:cd17330 296 KEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
50-390 |
5.68e-11 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 63.37 E-value: 5.68e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 50 PAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFG-STANPQM-- 126
Cdd:cd17335 31 PTQIGILIGIRPFVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFsAPVVPLVds 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 127 --FALAREHADKTGREavmfssflRAQVSLAWVIGpplAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMQKELPLA 204
Cdd:cd17335 111 itLQYLGEERERYGKQ--------RLWGSIGFGIA---ALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFRP 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 205 TGTVEAPR--------RNRRdTLLLFVICTLMWGSNSLYIINMPLFiINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFA 276
Cdd:cd17335 180 KHPEPNENtggllallRNPR-VLAFLLVAFLMGFGHGLIYSFLFWH-LQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLI 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 277 KRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMP-GQAGSATTLYTNTSR-VGWI 354
Cdd:cd17335 258 QRFGHVGLLYLGLLAYVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPpGLRATAQGLLQGLYFgLGGG 337
|
330 340 350
....*....|....*....|....*....|....*.
gi 446474149 355 IAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRI 390
Cdd:cd17335 338 LGSLIGGYLYEAFGARTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-388 |
7.33e-10 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 59.92 E-value: 7.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTdevharpamvgFFFTGSAVIGILVSQFLAGR-SDKRGDRKSLIVFCCLLGVL-ACT 97
Cdd:cd17316 15 FFLIGFVAPVLAAEFSLGLSLLQT-----------GLLFAAGFLGRPIGALLFGYlGDRIGRKKALILTLLLFGLAtLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 98 LFAWNrnyFVLLFVGVFLSSFGSTA-NPQMFALAREHADKTGReavmfsSFLRAQVSLAWVIGPPLAYALAMGFS-FTVM 175
Cdd:cd17316 84 GLLPT---PILLLVLRFLQGIGIGGeYPGASTYVAEFAPSKRR------GFALGLLQSGWALGALLAALVASLLIpLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 176 YLSAAVAFIVCGVMVWLFLPSmqkelplatgtveaprrnRRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAG 255
Cdd:cd17316 155 DWGWRILFLIGALPALLALLL------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSS 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 256 VMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAH--SPVILLGLQLLNAIFIGILGGIGMLYFQDL 333
Cdd:cd17316 217 LYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLsgSPTLLLLLLFILSFFVGGVWGALYAYLAEL 296
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446474149 334 MPGQA-GSATTLYTNTSRVGWIIAGS-VAGIVAEIWNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd17316 297 FPTEVrATGVGLSYNLGRLGGGGAPPlIALLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-185 |
2.47e-09 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 58.36 E-value: 2.47e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLF 99
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 100 AWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGP----PLAYALAMGFSFTVM 175
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ--GIIQSLQSLARIIGPllagPLYSFLGPGVPFLLA 336
|
170
....*....|
gi 446474149 176 YLSAAVAFIV 185
Cdd:cd17330 337 AGLLLIALFL 346
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-385 |
3.20e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 3.20e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIFLTDeVHARPAMVGFFfTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFA 100
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLV-VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 101 WNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLraQVSLAWVIGPPLAYALAMGFSFTVMYLSAA 180
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGL--ATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 181 VAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRDTLLLF-VICTLMWGSNSLYIINMPLFIINELHlpeKLAGVMMG 259
Cdd:cd17489 158 VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPaLILFLASIAYGAISTFLPLYAAERGI---SNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 260 TAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSP-VILLGLQLLNAIFIGILGGIGMLYFQDLMPGQA 338
Cdd:cd17489 235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPwMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRR 314
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446474149 339 GSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLF 385
Cdd:cd17489 315 GAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
210-389 |
5.60e-09 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 57.29 E-value: 5.60e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 210 APRRNRRDTLLLFVICTLMWGSNSLYIINMPLfIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAA 289
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 290 VGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPG-QAGSATTLYTNTSRVGWIIAGSVAGIVAEIWN 368
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180
....*....|....*....|.
gi 446474149 369 YHAVFWFAMVMIIATLFCLLR 389
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-193 |
7.52e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.81 E-value: 7.52e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 18 TAFLIVAFLTGIAGALQTpTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACT 97
Cdd:cd17474 202 TFLVSAFLYFFLYFAFLT-YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 98 LFAWNRNYfVLLFVGVFLSSFGS-TANPQMFALAREHADKTGREAVM--FSSFLRaqvsLAWVIGPPLAYALAMGFSFTV 174
Cdd:cd17474 281 LLGFVPSL-ALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTASslYNFVRF----LGQAVGPLLFGLLLEIFGLSA 355
|
170
....*....|....*....
gi 446474149 175 MYLSAAVAFIVCGVMVWLF 193
Cdd:cd17474 356 PFLVGAAIALAAAVLLALL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-391 |
8.98e-09 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.81 E-value: 8.98e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKsLIVFCCLLGVLACTL 98
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRR-VLLIGLLLLGIGLLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 99 FAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKtgREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:COG2223 87 LALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPP--DRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 179 AAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRN---RRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAG 255
Cdd:COG2223 165 LGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEalrDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAG 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 256 VMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMA-HSPVILLGLQLLNAIFIGILGGIGMLYFQDLM 334
Cdd:COG2223 245 LLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALAlGSLWLFLVLFLLLGLALGGGNGAVFALVPDIF 324
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446474149 335 PG-QAGSATTLYTNTSRVGWIIAGSVAGIVAEIW-NYHAVFWFAMVMIIATLFCLLRIK 391
Cdd:COG2223 325 PTkNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-390 |
1.30e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 52.96 E-value: 1.30e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLT--DEVHARPAMVGFFFTGSAVIGIlVSQFLAGR-SDKRGdRKSLIVFCCLLGVLAC 96
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAiaEALGASPAQVGLLITAFTLPAA-VLMPVAGVlADRFG-RKKVLLPGLLLFGIGG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 97 TLFAWNRNYFVLLFV----GVFLSSFGSTANPQMFALAREHAdktgREAVMfsSFLRAQVSLAWVIGPPLAYALAMGFSF 172
Cdd:cd17474 79 LLCGLSDSFALLLAGralqGIGAAGLGPLALTLIGDLFEGGE----RAKAM--GLYEAALGLGIAVGPLLGGLLAAISWR 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 173 TVMYLSAAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPR---RNRRDTLLLFVICTLMWGSnSLYIINMPLFIINELHL 249
Cdd:cd17474 153 YPFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKkalRGRGLLTFLVSAFLYFFLY-FAFLTYLPFLLELLYGI 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 250 PEKLAGVMMGTAAGLeipTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAG----MLMAHSPVILLGLQLLNAIFIGILGGI 325
Cdd:cd17474 232 SPIIIGLLFAGWSVL---LALGSLFVGRLLKKRFGARRILVIGLLLYALslllLGFVPSLALLLIAIVLFGLGLGLNLPL 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446474149 326 GMLYFQDLMPGQA-GSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLLRI 390
Cdd:cd17474 309 LTTLVTELAPEEErGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
63-388 |
1.54e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.96 E-value: 1.54e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 63 IGILVSQFLAGR-SDKRGDRKSLIVfcCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQM-FALAREHADktGRE 140
Cdd:cd17320 45 LGFALGQLLYGPlSDRFGRRPVLLA--GLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVaRAIVRDLYS--GAE 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 141 AVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLP---SMQKELPLATGTVEAPRRNRRD 217
Cdd:cd17320 121 LAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPetlPEEKRKPLLSSLLRAYKRVLKN 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 218 TLLLF--VICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAV----- 290
Cdd:cd17320 201 RRFLGyaLALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLlllaa 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 291 GGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQAGSATTLYtNTSRVGwiIAGSVAGIVAEIWNyH 370
Cdd:cd17320 281 ALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALL-GFLQFL--IGALAGALVGLLPN-G 356
|
330
....*....|....*...
gi 446474149 371 AVFWFAMVMIIATLFCLL 388
Cdd:cd17320 357 TALPMGLLILVLGLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-392 |
1.90e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 52.42 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 221 LFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGML 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 301 MAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQA-GSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVM 379
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|...
gi 446474149 380 IIATLFCLLRIKD 392
Cdd:pfam07690 161 SLLAAVLLLLPRP 173
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
227-393 |
2.06e-06 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 49.13 E-value: 2.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 227 LMWGSNSLYIINMPLFIInELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPV 306
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 307 ILLGLQLLNAIFIGILGGIGMLYFQDLMPGQ-AGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLF 385
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSrRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
....*...
gi 446474149 386 CLLRIKDV 393
Cdd:cd17489 166 LVFLVKDP 173
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-388 |
2.70e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 49.16 E-value: 2.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 36 PTLSIFLTDEVHARPAMVGFFfTGSAVIGILVSQFLAGR-SDKRGDRKSLIVFCCLLGVLACtLFAWNRNYFVLLFVGVF 114
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLL-LSALNLGVAVSMLPAGWlLDRFGERRVLAVGLLLMGAAAL-LMALVGSYPVLLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 115 LSSFGSTANPqmfalarehadkTGREAVM--FSSFLR--------AQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFI 184
Cdd:cd17475 94 VGAGYGSVQP------------GGGRAIMrwFPPRERglamgirqTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 185 VCGVMVWLFL-----PSMQKELPLAT-GTVEAPRRNrRDTLLLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMM 258
Cdd:cd17475 162 LAAVLFWLFYreppaASAATESASTLlRSLKEVLRN-RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 259 GTAAGLEIPTMLIAGYFAKRL--GKRF-LMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLM- 334
Cdd:cd17475 241 AVAQLGGALGRIGLGRVSDRVfgGRRRpVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAe 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446474149 335 ---PGQAGSATTLYTNTSRVGWIIAGSVAG-IVAEIWNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd17475 321 sagPEQAGTALGLANTINFIGIAIGPPLFGlLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
24-309 |
4.62e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 48.37 E-value: 4.62e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 24 AFLTGIAGALQTPTLSiFLTDEVHARPAMVGFFFTGSAVIGiLVSQFLAGR-SDKRGDRKSLIVfCCLLGVLACTLFAWN 102
Cdd:cd17331 9 IVLYATCYWLQQPVLP-YLTKKLGVDSVVFGYLQTTFSVLQ-LVGGPLFGRfGDLFGPRAALVL-SFLSSALSYLLLAFA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 103 RNYFVLlfvgvFLSSFGSTANPQMFALAREHADKTGREAvmfssflRAQ----VSLAW----VIGPPLAYALAMGFSFTV 174
Cdd:cd17331 86 SSVPML-----FLSRLPSVFMHAMQAAQMVVTDLTDPGE-------RAAalgrLGLSYgigmVVGSFLGGLLTKKFGEQA 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 175 MYLSAAVAFIVCGVMVWLFLPSMQKEL-----------PLATGTVEAPRRNR-RDTLLLFVICTLMWGSNSLYIINMPLF 242
Cdd:cd17331 154 AALVAAVGSLLSIVLVILLIPSNTKSKrekeakesaspPSVFNLKEILRLLRlPGVAFLLLVKLLSGLPIGMFQSMFSLV 233
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446474149 243 IINELHLPEKLAGVMMGTAAGLEIPTM-LIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILL 309
Cdd:cd17331 234 AMDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLL 301
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
21-311 |
9.50e-06 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 47.18 E-value: 9.50e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAvIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFA 100
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPA-LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 101 WNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYALAmGFSFTVMYLSAA 180
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 181 VAFIVcGVMVWLFLPSMQKELPLATGTVEAPRRnRRDTLLLFVICTLMWGSNSLY---IINMPLFIINELHLPEKLAGVM 257
Cdd:cd17473 161 LALPV-LILVLLFLPEPARKSKSAASPGAATAA-ALPWKRVLPIYFLAFLAMLLFyviPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446474149 258 MGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHS-PVILLGL 311
Cdd:cd17473 239 LAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGlWVVLLGA 293
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
220-392 |
1.12e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 220 LLFVICTLMWGSnSLYIINMPLFIiNELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGM 299
Cdd:cd17325 1 LSLALFLDMLGY-GIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 300 LMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMP-GQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMV 378
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170
....*....|....
gi 446474149 379 MIIATLFCLLRIKD 392
Cdd:cd17325 159 LALLALVLALLLLP 172
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-384 |
1.20e-05 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 46.77 E-value: 1.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 22 IVAFLTGIAGALQTPTLSIFLTdEVHARPAMVGFFfTGSAVIGILVSQFLAGR-SDKRGDRKSLIVFCCLLGVLACTLFA 100
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLV-VLGASAAAVGLI-EGLAEALGSLLRLFSGYlSDRTGKRKPLVILGYGLSALAKPLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 101 WNRNYFVLLFVgVFLSSFGSTA-NPQMFALAREHADKTGREAVMfsSFLRAQVSLAWVIGPPLAYAL--AMGFSF-TVMY 176
Cdd:cd17370 84 LAGSWQLVLLL-RILERLGKGIrTPPRDALLADATPPSGRGKAF--GLHRALDTLGAVLGPLLAALLlyLLGGNYrTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 177 LSAAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRDTLLLFVICTLMWGSNSLYIinMPLFIINELHLPEKLAGV 256
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFA--FLILRAQELGLSAALIPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 257 MMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPG 336
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446474149 337 QA-GSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATL 384
Cdd:cd17370 319 ELrGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
19-190 |
1.44e-05 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 46.86 E-value: 1.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKR-GDRKSLIVFCCLLGvLACT 97
Cdd:cd17388 210 GLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRlGEKRAILLGLAADA-LGFL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 98 LFAWNRNYFvLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSsfLRAQVSLAWVIGPPLAYALamgFSFTVMYL 177
Cdd:cd17388 289 LLAFATQGW-MVFPILILLALGGIAGPALQGLLSRQVPENEQGELQGV--LTSLTSLTSIIGPLLFTGI---FAASPATW 362
|
170
....*....|...
gi 446474149 178 SAAVAFIVCGVMV 190
Cdd:cd17388 363 PGLAWIIGAALYL 375
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
25-340 |
1.96e-05 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 46.08 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 25 FLTGIAGALQtPTLSIFLTDeVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVL--ACTLFAWN 102
Cdd:pfam12832 10 FYFAALGCLL-PYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVlfLSVLFIPI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 103 RNYFVLLFVGVFLSS-FGSTANPQMFALAREH-ADKTGReavmFSSfLRAQVSLAWVIgppLAYALAMGFSFTVMYLSAA 180
Cdd:pfam12832 88 SLTFWWLALLVVLFSfFWNAILPQFEVATLQHlGEKRKD----YGR-QRLWGSVGFAL---SVFGLGALFDHYSVGLLPS 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 181 VAFIVC-GVMVWLFL-----PSMQKELPLATGTVEAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIiNELHLPEKLA 254
Cdd:pfam12832 160 VLFYLFaALMLLSLLlplapPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLLGFSHGPFYTFLFLYL-ENLGASNTLL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 255 GVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVA-AVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDL 333
Cdd:pfam12832 239 GALWALGVVAEIPLFFYAHRLLRRFGHRNLLIIAlLLTALRWLLYAFFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRI 318
|
....*..
gi 446474149 334 MPGQAGS 340
Cdd:pfam12832 319 FPGSLQG 325
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-390 |
2.26e-05 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 46.02 E-value: 2.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 16 TSTAFLIVAFLTGIAGALQTPTLSI-----FLTDEVHARPAMVGFFFTgSAVIGILVSQFLAGR-SDKRGDRKSLIVfcC 89
Cdd:COG2807 13 RAGRWLLLLAIVLVALNLRPAITSVgpllpEIRADLGLSATQAGLLTT-LPLLAFGLFAPLAPRlARRFGLERTLLL--A 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 90 LLGVLACTLFAWNRNYFVLLFVGVFLSSFGST-ANPQMFALAREH-ADKTGREAVMFSSFLraqvSLAWVIGPPLAYALA 167
Cdd:COG2807 90 LLLLAAGLLLRSLAPSVALLLAGTALIGAGIAvGNVLLPGLIKRWfPDRVGLMTGLYTAAM----GLGAALAAGLTVPLA 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 168 MGFSFTVMYLSAAVaFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNRRDTLLLFVicTLMWGSNSL--YIIN--MPLFI 243
Cdd:COG2807 166 AALGWRGALAVWAL-LALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLL--TLFFGLQSLlyYAVVawLPPIL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 244 InELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLG-KRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGIL 322
Cdd:COG2807 243 R-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLF 321
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446474149 323 GGIGMLyFQDLMPGQAGSAtTLYTNTSRVGWIIAGS---VAGIVAEIW-NYHAVFWFAMVMIIATLFCLLRI 390
Cdd:COG2807 322 PLALTL-IGLRARTPAEAA-ALSGMAQSVGYLLAALgplLVGALHDATgSWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
51-194 |
1.68e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.35 E-value: 1.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 51 AMVGFFFTGSAvIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALA 130
Cdd:cd17489 227 SNAGLFFTVYA-IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALA 305
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446474149 131 REHADKTGREAVM--FSSFLRaqvsLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFL 194
Cdd:cd17489 306 VDLVPPHRRGAANgtFFIFFD----LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
20-123 |
2.53e-04 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 42.98 E-value: 2.53e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLF 99
Cdd:cd17331 212 LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
|
90 100
....*....|....*....|....
gi 446474149 100 AWNRNYFVLLFVGVFLSSFGSTAN 123
Cdd:cd17331 292 AFVTTVWQLLVLLLPLVIGGSVLY 315
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-309 |
3.41e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 42.26 E-value: 3.41e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIFLTDEVHAR---PAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRkSLIVFCCLLGVLACT 97
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFgwsRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPR-RVMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 98 LFAWNRNYFVLlFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGPPLAYALAMGFSFTVMYL 177
Cdd:cd17355 84 LLALATSLWQL-YLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 178 SAAVAFIVCGVMVWLFLPSMQKELPLATGTVEAPRRNR-------RDTLLLFVICTLMWGSNSLYIINMPLFI-INELHL 249
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGstlkealRSASFWLLALAFFLCGFAVVGLIVHLVPyLADRGI 242
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 250 PEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILL 309
Cdd:cd17355 243 SPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLAL 302
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
63-390 |
4.98e-04 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 41.79 E-value: 4.98e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 63 IGILVSQFLAGR-SDKRGDRKSLIVFCCLLGvLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGReA 141
Cdd:cd17319 49 LGYALFQVPGGWlLDRFGARKVLAVSMLLWS-LFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARER-G 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 142 VMFSSFLRAQvSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMqkelplatgtveaprrnrrdtLLL 221
Cdd:cd17319 127 RATGLFNSGA-PLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYLRQV---------------------WGL 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 222 FVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLM 301
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGLLLAAVGLLL 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 302 A---HSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPG-QAGSATTLYTNTSRVGWIIAGSVAG-IVAEIWNYHAVFWFA 376
Cdd:cd17319 265 AyltTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGeAAATAGGLINSGGNLGGFVAPLLIGyLVDATGSYTAAFLFL 344
|
330
....*....|....
gi 446474149 377 MVMIIATLFCLLRI 390
Cdd:cd17319 345 AAVALLAALLVLLL 358
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-385 |
6.94e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 6.94e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 21 LIVAFLTGIAGALQTPTLSIFLTDEvHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFA 100
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 101 WNRnyFVLLFVGVFLSSFGSTAnpqMFALAR----EHADKTGREAVMfsSFLRAQVSLAWVIGPPLAyALAMGFSFTvMY 176
Cdd:cd17477 81 TDS--PWVWFLLRFVMGIGLAG---LFVVSEswlnALATNENRGRVL--GLYSTVLGLGFALGPLLL-ALVGTAGAL-PF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 177 LSAAVAFIVCGVMVwLFLPSMQKELPLATGTveAPRRNRRDTLLLFVICTLMWGSNSLYIINMPLFIInELHLPEKLAGV 256
Cdd:cd17477 152 LIAAVLLLLALVPL-LLTRRAAPEIEEAESI--SLRRLLRIAPLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 257 MMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGV--CFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLM 334
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGAlaALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLP 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446474149 335 PGQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLF 385
Cdd:cd17477 308 GDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
220-315 |
7.44e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 41.44 E-value: 7.44e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 220 LLFVICTLMWGSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGM 299
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90
....*....|....*.
gi 446474149 300 LMAHSPVILLGLQLLN 315
Cdd:cd17329 83 GFAHSPWLFAIALVLT 98
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
221-392 |
7.88e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 41.05 E-value: 7.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 221 LFVICTLMWGSNSLYIINMPLFIiNELHLPEKLAGVMMGTAAgleIPTMLI---AGYFAKRLGKRFLMRVAAVGGVCFYA 297
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYA-ESLGASLSMIGIILGAYG---ISQMLLripLGILSDRIGKRKLFIIIGLLFTVLAS 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 298 -GMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFA 376
Cdd:cd17490 77 lIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLA 156
|
170
....*....|....*.
gi 446474149 377 MVMIIATLFCLLRIKD 392
Cdd:cd17490 157 ALAGVLGFILSLFIKE 172
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
270-388 |
1.21e-03 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 40.67 E-value: 1.21e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 270 LIAGYFAKRLGKR------FLMRVAAVGGVCFYAGMLMAHSPVILLGLQ-LLNAIFIGILGGIGMLYFQDLMPGQAGSAT 342
Cdd:cd17485 261 LLGGYLLKRRGRRrllllgGLLRLLLLGLYTLLALGGSGLNWVLLLASLaLLHLVGGMITTALFTLMMDCSQQAQAGTDY 340
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446474149 343 TLYTNTSRVGWIIAGSVAGIVAEIWNYHAVFWFAMVMIIATLFCLL 388
Cdd:cd17485 341 TLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVLLLL 386
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
51-119 |
1.53e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 40.52 E-value: 1.53e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 51 AMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVF-LSSFG 119
Cdd:COG2270 52 ALWGYALAIAGLLVALLAPVLGAIADRSGRKKPFLAFFTLLGVLATAALFFVAPGGLWLGLLLFvLANIG 121
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
53-388 |
4.72e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.84 E-value: 4.72e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 53 VGFFFTGSAvIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFL----SSFGSTANPQMFA 128
Cdd:cd17333 33 VSVIFSSQN-AGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAglgaGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 129 LAREhadktGREAVMfsSFLRAQVSLAWVIGPPLA-YALAMGFSFTVMYLsAAVAFIVCGVMVWLFLPSMQKE---LPLA 204
Cdd:cd17333 112 LFEE-----SSATRL--NVLHGFFGLGALIGPLIAtSLLTSELSWSWAYL-IIGLIYLLLAILILLTLFPELPsarNPQQ 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 205 TGTVEAP---RRNRRDTLLLFVICTLMW-GSNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLG 280
Cdd:cd17333 184 SVGAFSAsasRLLRNPSIILGALALFLYvGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIK 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 281 KRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSVA 360
Cdd:cd17333 264 PHTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIM 343
|
330 340
....*....|....*....|....*....
gi 446474149 361 GIVAEIWNYHAVFWFAMVM-IIATLFCLL 388
Cdd:cd17333 344 GFIAEAVGIQTAMLLITILyAIIFVLALL 372
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
18-200 |
7.84e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 37.94 E-value: 7.84e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 18 TAFLIVAFLTGIAGALQTPTlsiFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGDRKSLIVFCCLLGVLACT 97
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPP---YLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 98 LFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVmfSSFLRAQVSLAWVIGPPLA-YALAMGFSFTVMY 176
Cdd:COG2223 288 LALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAV--YGLVGAAGGLGGFLGPLLFgALLDATGSYTAAF 365
|
170 180
....*....|....*....|....
gi 446474149 177 LSAAVAFIVCGVMVWLFLPSMQKE 200
Cdd:COG2223 366 LVFAVLALVALVLTLLLYRRPRRA 389
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
243-390 |
7.91e-03 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 38.18 E-value: 7.91e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474149 243 IINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVGGVCFYAGMLMAHSPVILLGLQLLNAIFIGIL 322
Cdd:cd06174 22 LLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLI 101
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446474149 323 GGIGMLYFQDLMPG-QAGSATTLYTNTSRVGWIIAGSVAGIVAEI--WNYHAVFWFAMVMIIATLFCLLRI 390
Cdd:cd06174 102 DPAVLALIADLFPErERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAALALLAAILLLLV 172
|
|
| |
