|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15011 |
PRK15011 |
sugar efflux transporter SetB; |
1-393 |
0e+00 |
|
sugar efflux transporter SetB;
Pssm-ID: 184973 Cd Length: 393 Bit Score: 700.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 1 MHNSPAAAAPKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGD 80
Cdd:PRK15011 1 MHNSPAVSSAKSFDLTSTAFLIVAFLTGIAGALQTPTLSIFLTDEVHARPAMVGFFFTGSAVIGILVSQFLAGRSDKRGD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 81 RKKLIVFCCVLGMLACVLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSILRAQVSLAWVIGP 160
Cdd:PRK15011 81 RKSLIVFCCLLGVLACTLFAWNRNYFVLLFVGVFLSSFGSTANPQMFALAREHADKTGREAVMFSSFLRAQVSLAWVIGP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 161 PLAYALAMGFSFTVMYLSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIINMP 240
Cdd:PRK15011 161 PLAYALAMGFSFTVMYLSAAVAFIVCGVMVWLFLPSMRKELPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIINMP 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 241 LFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIG 320
Cdd:PRK15011 241 LFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRFLMRVAAVAGVCFYAGMLMAHSPAILLGLQLLNAIYIG 320
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446474088 321 ILGGIGMLYFQDLMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARIKDV 393
Cdd:PRK15011 321 ILGGIGMLYFQDLMPGQAGSATTLYTNTSRVGWIIAGSLAGIVAEIWNYHAVFWFALVMIIATLFCLLRIKDV 393
|
|
| 2A0120 |
TIGR00899 |
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, ... |
19-392 |
0e+00 |
|
sugar efflux transporter; This family of proteins is an efflux system for lactose, glucose, aromatic glucosides and galactosides, cellobiose, maltose, a-methyl glucoside and other sugar compounds. They are found in both gram-negative and gram-postitive bacteria. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 129977 Cd Length: 375 Bit Score: 522.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVL 98
Cdd:TIGR00899 1 AFLLVAFLTGIAGALQFPTLSLFLSEEVRARPAMIGLFYTGSAIVGIAVSQLLATRSDYQGDRKGLILFCCLLAALACLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 99 FAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:TIGR00899 81 FAWNRNYFLLLVLGVLLSSFASTANPQLFALAREHADRTGREAVMFSSVMRAQISLAWVIGPPLAFWLALGFGFTVMFLT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 179 AAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAP-RRNRRDTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVM 257
Cdd:TIGR00899 161 AALAFVLCGVLVWLFLPSYPRGAPGALTRLEVRgLLASRDTRLLFVACTLMWGCNILYIINMPLLIIHELGLPDKLAGLM 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 258 MGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQ 337
Cdd:TIGR00899 241 MGTAAGLEIPFMLLAGYLIKRFGKRRLMLLAALAGVAFYTGLAADNSLWALLMLQLLNAIFIGILAGIGMLYFQDLMPGR 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446474088 338 AGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARIKD 392
Cdd:TIGR00899 321 AGAATTLYTNTGRVGWIIAGSVGGILAERWSYHAVYWFAIVMLIVALFCLLLIKD 375
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-387 |
1.97e-140 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 404.62 E-value: 1.97e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLF 99
Cdd:cd17471 1 LLLATLLTGLAGAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLILLALLAGALGYLLF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADR-TGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:cd17471 81 AFLRNYWVLLLVGVVLLSLGAAAFPQLFALAREYADRsSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 179 AAVAFIVCSVMVWFFLPSMRKDAPLATGTL-EAPRRNRRDTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVM 257
Cdd:cd17471 161 AALLYLVVALLVLFLLPSVKPPAQKATPASsLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 258 MGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQ 337
Cdd:cd17471 241 FGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGVLFYLGLALATSLWQLIALQLLNAIFIGITAGLGISYFQDLMPGQ 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 446474088 338 AGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCL 387
Cdd:cd17471 321 PGLATTLYSNASRIGSLLGGLLAGVIAQYFGYRAVFLVCAVLALLALVLL 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
7-356 |
4.98e-25 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 104.29 E-value: 4.98e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 7 AAAPKSFDLTSTAFLIVAFLTGIAGALQTPTLSiFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIV 86
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG-RRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 87 FCCVLGMLACVLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYAL 166
Cdd:COG2814 80 LGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRAL--GLLGAGLGLGPALGPLLGGLL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 167 AMGFSFTVMYLSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIINMPLFIINE 246
Cdd:COG2814 158 ADLFGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEV 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 247 LHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIG 326
Cdd:COG2814 238 LGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLL 317
|
330 340 350
....*....|....*....|....*....|.
gi 446474088 327 MLYFQDLMPGQA-GSATTLYTNTIRVGWIIA 356
Cdd:COG2814 318 QALVAELAPPEArGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
20-391 |
1.30e-20 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 92.25 E-value: 1.30e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTdEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGMLACVLF 99
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLYAE-SLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFG-RKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSA 179
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAM--GIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVC 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 180 AVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPR------RNRRDTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKL 253
Cdd:cd17325 157 AALALLALVLALLLLPEPRPPPNKRAVSAARLRsglrllLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQ 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 254 AGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDL 333
Cdd:cd17325 237 IGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADI 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446474088 334 MP-GQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARIK 391
Cdd:cd17325 317 VPpEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-387 |
1.50e-20 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 92.10 E-value: 1.50e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDeVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGMLACVLF 99
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQS-FGLSASQLGLLFALFSLGYALLQPLAGLLADRFG-RRPVLLLGLLLFALGALLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAM--GFSFTVMYL 177
Cdd:cd06174 79 AFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRAL--GLLQAFGSVGGILGPLLGGILASslGFGWRAVFL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 178 SAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPR--------RNRRDTLLLFVICTLMWGTNSLYIINMPLFIINELHL 249
Cdd:cd06174 157 IAAALALLAAILLLLVVPDPPESARAKNEEASSKSvlkllkrvLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 250 PEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRL-LMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGML 328
Cdd:cd06174 237 SVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKpLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFA 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446474088 329 YFQDLMP-GQAGSATTLYTNTIRVGWIIAGSLAG-IAAEIWNYHAVFWFALVMIVATMFCL 387
Cdd:cd06174 317 LIAELFPpEIRGTAFGLLNTFGFLGGAIGPLLAGfLLAATFGLTGAFLVLAVLLLLAAILL 377
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-356 |
8.84e-20 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 89.40 E-value: 8.84e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAvIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLF 99
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFS-LGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSA 179
Cdd:pfam07690 80 LFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRAL--GLVSAGFGLGAALGPLLGGLLASLFGWRAAFLIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 180 AVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRN------RRDTLLLFVICTLMWGTNSLYIINMPLFiINELHLPEKL 253
Cdd:pfam07690 158 AILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVawkallRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 254 AGVMMGTAAGLEIPTMLIAGYFAKRLGKR---LLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYF 330
Cdd:pfam07690 237 AGLLLGLGGLLGAIGRLLLGRLSDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALV 316
|
330 340
....*....|....*....|....*..
gi 446474088 331 QDLMP-GQAGSATTLYTNTIRVGWIIA 356
Cdd:pfam07690 317 SDLAPkEERGTASGLYNTAGSLGGALG 343
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
15-386 |
2.42e-18 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 85.68 E-value: 2.42e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 15 LTSTAFLIVAFLTGIAGALQTptlsifLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGML 94
Cdd:cd17324 4 LALAAFAIGTTEYVIQGLLPD------IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIE-RRRLLLVLLLLFIL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 95 ACVLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTV 174
Cdd:cd17324 77 GNLLAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAI--GLVFSGLTLGLVLGRPLGGLLGQLLGWRA 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 175 MYLSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRD--TLLLFVICTLMWGTNSLYIINMPLFIINELHLPEK 252
Cdd:cd17324 155 AFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLLLRNprLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 253 LAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQD 332
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLR 314
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446474088 333 LMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFC 386
Cdd:cd17324 315 LAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLL 368
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
19-391 |
3.71e-17 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 82.64 E-value: 3.71e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSD----KKGDRKKLIVFCCVLGML 94
Cdd:COG2211 14 AYGLGDLGLNLAFGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWILIGAIPLAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 95 ACVLFAWNRN-----YFILLFIGVFLSSFGSTA-----NPQMFALAREHADRTgreavMFSSILRAQVSLAWVIGPPLAY 164
Cdd:COG2211 94 SFVLLFTAPDlsptgKLIYALVTYLLLGLAYTLvnipySALGAELTPDYEERT-----RLSSWRFAFAGLGGLLASVLPP 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 165 ALAMGFS------FTVMYLSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLE---APRRNRrDTLLLFVICTLMWGTNSLY 235
Cdd:COG2211 169 PLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKEslkALLKNR-PFLLLLLAYLLFFLALALV 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 236 IINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHA--PATLLGLQL 313
Cdd:COG2211 248 AALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPgnLWLLLVLAA 327
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 314 LNAIYIGILGGIGMLYFQDLMP--------GQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHA-------------- 371
Cdd:COG2211 328 LAGIGLGAILVLPWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAgaaqspsaltgirl 407
|
410 420
....*....|....*....|.
gi 446474088 372 -VFWFALVMIVATMFCLARIK 391
Cdd:COG2211 408 lFFLLPAVLLLLAALLLLFYP 428
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
21-390 |
1.71e-14 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 74.19 E-value: 1.71e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSqFLAGRSDKKGDRKKLIVFCCVLGMLACVLFA 100
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVAS-LIGGRLADRFGRKPVMLAGLLLRALGFALLG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 101 WNRNyFILLFIGVFLSSFGSTA-NPQMFALAREHADRTGREAVmfSSILRAQVSLAWVIGPPLAYALAMgFSFTVMYLSA 179
Cdd:cd17329 84 FAHS-PWLFAIALVLTGFGGGLfEPASEAMIADVTTPENRTRA--FSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFLAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 180 AVAFIVCSVMVWFFLP--SMRKDAPLATGTLEAPRRNRRDT-----LLLFVICTLMWGTNSLYIinmPLFIINELHLPEK 252
Cdd:cd17329 160 AVLFLLAALVLLFLLPetRPKRRAAEKTEILRGYKIVLRDRafllfLLASFLISLIYFQLESTL---PVYVVEILGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 253 LAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQD 332
Cdd:cd17329 237 LLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAA 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446474088 333 LMP-GQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARI 390
Cdd:cd17329 317 LAPpDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGL 375
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
19-389 |
1.82e-14 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 74.19 E-value: 1.82e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTPTLSIFLTDeVHARPGMVGFFFTGSAVIGIIVSqFLAGRSDKKGDRKKLIVFC----CVLGML 94
Cdd:cd06173 3 LLWLAQLLSALGDWIFTVALPWLVLQ-LTGSALLVGLVLAAFFLPFLLFS-PFAGVLADRFDRRRLLILAdllrALLAAV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 95 ACVLFAWNRNYFILLFIGVFLSSFGSTA-NPQMFALAREHADRtgREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFT 173
Cdd:cd06173 81 LALLALLGSLSLWLLLVLAFLLGIASAFfGPARQALLPELVPK--EQLVRANALNSLATQLARIIGPALGGLLVALLGPG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 174 VMYLSAAVAFIVCSVMVWF-----FLPSMRKDAPLATGTLEAPRRNRRDTLLLFVICT--LMWGTNSLYIINMPLFIINE 246
Cdd:cd06173 159 GAFAINALSFLLSALLLLFirrppPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLAlaLFALLGGALTVLLPLLAKEV 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 247 LHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIG 326
Cdd:cd06173 239 LGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPL 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446474088 327 MLYFQDLMPGQ-AGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFW-FALVMIVATMFCLAR 389
Cdd:cd06173 319 NTLLQLRVPDElRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLlAGALLLLAALLLLLL 383
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
19-194 |
2.78e-14 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 73.38 E-value: 2.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGMLACVL 98
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG-RKPLILIGLLLSAVALLL 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 99 FAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:cd17325 282 LPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAM--GLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLA 359
|
170
....*....|....*.
gi 446474088 179 AAVAFIVCSVMVWFFL 194
Cdd:cd17325 360 AAALLLLAAVLFLLLR 375
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
21-385 |
1.27e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 68.37 E-value: 1.27e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIFLTDEV--HARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGMLACVL 98
Cdd:cd17330 2 FLVVFLDALGFGIVFPVLPFYVREFNklGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYG-RKPVLLLSLAGSAVSYVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 99 FAWNRNyFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLS 178
Cdd:cd17330 81 LGLSRN-LWLLFLARFLDGLTGGNVSVAQAYIADITDEEERAKAF--GIISAAFGLGFILGPALGGFLSTPYGYALPFLV 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 179 AAVAFIVCSVMVWFFLPSMRkdaplatgtleaprrnrrdtlLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMM 258
Cdd:cd17330 158 AAALALLNLVLVLFFLPPLR---------------------RLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLL 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 259 GTAAGLEIPT-MLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATL-LGLQLLNAIYIGILGGIGMLYFQDLMPG 336
Cdd:cd17330 217 ALVGIAGILAqLLLIPRLAKRLGERKLLRLGLLLAIIGLLLLPFASSVPLLvLAAAILAFGTGIVFPALSALLSKSVPSK 296
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446474088 337 QAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMF 385
Cdd:cd17330 297 EQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLLAAGLLLIALF 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
21-391 |
1.46e-12 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 68.36 E-value: 1.46e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIF---LTDEVHARPGMVGFFFTgSAVIGIIVSQFLAGR-SDKKGdRKKLIVFCCVLGMLAC 96
Cdd:COG2271 12 LALLFLAYFLNYLDRSNLSVAappLQADLGLSAAQLGLLAS-AFFLGYALGQIPAGLlADRFG-RRRVLAIGLLLWGLAT 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 97 VLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRtgREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMY 176
Cdd:COG2271 90 LLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPP--KERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAF 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 177 LSAAVAFIVCSVMVwfflpsmrkdaplatgtleaprrnrrdTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGV 256
Cdd:COG2271 168 LILGLPGLLLALLR---------------------------FWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGL 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 257 MMGTAAGLEIPTMLIAGYFAKRLGKR--LLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLM 334
Cdd:COG2271 221 LLSLPFLAGIVGSLLGGWLSDRLGRRrkLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELF 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446474088 335 PGQ-AGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARIK 391
Cdd:COG2271 301 PKKaRGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLL 358
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-391 |
3.26e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 67.19 E-value: 3.26e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 15 LTSTAFLIVAFLTGIAGALQTptlsiFLTDEVHARPGMVGFFFTGSAvIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGML 94
Cdd:COG0738 12 AIYLLFFLWGFATALWGPLIP-----ALKDAFGLSDAQAGLLLFAFF-LGYLLASLPAGRLIDRFGYKRGLLLGLLLMAL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 95 ACVLFAWNRNYFILL----FIGVFLSSFGSTANPQMFALAREHADRtgreavmFSSILRAQVSLAWVIGPPL-AYALAMG 169
Cdd:COG0738 86 GLLLFALAPSYPLLLlalfLLGLGLGLLDVAANPYVAALGPETAAS-------RLNLLHAFFSLGALLGPLLgGLLILLG 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 170 FSFTVMYLSAAVAFIVCSVMVWFF---LPSMRKDAPLATGTLEAPRR--NRRDTLLLFVICTLMWGTNSLYIINMPLFII 244
Cdd:COG0738 159 LSLSWHLPYLILAVLLLLLALLFLrskLPEIEEEEEEAAGSAASLKSllKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLK 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 245 NELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLG-KRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLnAIYIGILG 323
Cdd:COG0738 239 DVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGpVRLLRLSALLAAVGLLLALLAPGPWLALIGLALV-GLGLSLMF 317
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446474088 324 GIGMLYFQDLMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARIK 391
Cdd:COG0738 318 PTIFSLALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALK 385
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
51-388 |
4.31e-11 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 63.73 E-value: 4.31e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 51 GMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGMLACVLFAWNRNYFiLLFIGVFLSSFGSTA-NPQMFAL 129
Cdd:cd17478 31 AQAGLLVSVFSITSSLLQPLFGYLADRKP-RRYLLPLGPLLTGLGLSLLGFAPNYW-LLLLLVALAGIGSAAfHPEGARL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 130 AREHAdrtGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVcSVMVWFFLPSMRKDAPLATGTLE 209
Cdd:cd17478 109 ASQAA---GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLA-VALLLLRLRPLKKPEAKKAAAKS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 210 APRRNRRDTLLLFVICTLMWGTNSLYIINMPLFI---INELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMC 286
Cdd:cd17478 185 SARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLpfyLVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVII 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 287 IAVVAGLCFYAGMLLAHAPATLLGLQLLNAiYIGILGGIGMLYFQDLMPGQAGSATTLytnTIRVGWIIAG---SLAGIA 363
Cdd:cd17478 265 ASLLLAAPFLLLFLLTPGIWSYILLVLAGF-LLFASFPVTVVLAQELLPGNVGLASGL---MMGLSFGLGGigaPVLGAL 340
|
330 340
....*....|....*....|....*
gi 446474088 364 AEIWNYHAVFWFALVMIVATMFCLA 388
Cdd:cd17478 341 ADAFGLESVLLILALLPLLGALLAF 365
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
62-390 |
1.07e-10 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 62.60 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 62 VIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFAWNRNYFILLFIGVFLSSFG-STANPQM----FALAREHADR 136
Cdd:cd17335 43 FVRFLSAPLWGALADRFGKRKALLLLSLLAAVLFFLSLFFVAQIFWLLLLLVILGAFFsAPVVPLVdsitLQYLGEERER 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 137 TGREAvMFSSIlraqvslAWVIGPPLAYALAMGFSFTVMY---LSAAVAFIVCSVMV--WFFLPSMRKDAPLATGTLEAP 211
Cdd:cd17335 123 YGKQR-LWGSI-------GFGIAALLVGILIDRSSTYKNYtiaFYVFAVLMLLALLLalKFPFRPKHPEPNENTGGLLAL 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 212 RRNRRdTLLLFVICTLMWGTNSLYIINMPLFiINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVA 291
Cdd:cd17335 195 LRNPR-VLAFLLVAFLMGFGHGLIYSFLFWH-LQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLA 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 292 GLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMP-GQAGSATTLYTNTIR-VGWIIAGSLAGIAAEIWNY 369
Cdd:cd17335 273 YVVRWLLYSFLENPWLVLPIELLHGLTFALVWAAAVSYASAAAPpGLRATAQGLLQGLYFgLGGGLGSLIGGYLYEAFGA 352
|
330 340
....*....|....*....|.
gi 446474088 370 HAVFWFALVMIVATMFCLARI 390
Cdd:cd17335 353 RTTFRFFAIAALAGLLAFFLI 373
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
20-185 |
2.22e-10 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 61.44 E-value: 2.22e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLF 99
Cdd:cd17330 179 LLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGLLLL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGP----PLAYALAMGFSFTVM 175
Cdd:cd17330 259 PFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQ--GIIQSLQSLARIIGPllagPLYSFLGPGVPFLLA 336
|
170
....*....|
gi 446474088 176 YLSAAVAFIV 185
Cdd:cd17330 337 AGLLLIALFL 346
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
21-385 |
2.90e-09 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 57.99 E-value: 2.90e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIFLTDeVHARPGMVGFFfTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFA 100
Cdd:cd17489 2 LLANFFFFLSFYLLLPVLPLYAHD-LGGSEAVAGLV-VGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 101 WNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAA 180
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGI--GYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 181 VAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLF-VICTLMWGTNSLYIINMPLFIINELHlpeKLAGVMMG 259
Cdd:cd17489 158 VLALLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPaLILFLASIAYGAISTFLPLYAAERGI---SNAGLFFT 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 260 TAAGleipTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLM----- 334
Cdd:cd17489 235 VYAI----ALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAvdlvp 310
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446474088 335 PGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMF 385
Cdd:cd17489 311 PHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALV 361
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-193 |
9.49e-09 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 56.42 E-value: 9.49e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 18 TAFLIVAFLTGIAGALQTpTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACV 97
Cdd:cd17474 202 TFLVSAFLYFFLYFAFLT-YLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 98 LFAWNRNYfILLFIGVFLSSFGS-TANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMY 176
Cdd:cd17474 281 LLGFVPSL-ALLLIAIVLFGLGLgLNLPLLTTLVTELAPEEERGTAS--SLYNFVRFLGQAVGPLLFGLLLEIFGLSAPF 357
|
170
....*....|....*..
gi 446474088 177 LSAAVAFIVCSVMVWFF 193
Cdd:cd17474 358 LVGAAIALAAAVLLALL 374
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
19-309 |
1.18e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.43 E-value: 1.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTgSAVIGIIVSQFLAGR-SDKKGdRKKLIVFCCVLGMLACV 97
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFA-IPVLVGALLRIPLGFlVDRFG-PRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 98 LFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREH--ADRTGreavMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVM 175
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWfpPDRRG----LALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 176 YLSAAVAFIVCSVMVWFFL----PSMRKDAPLATGTLEAPRRNRRdTLLLFVICTLMWGTNSLYIINMPLFIINELHLPE 251
Cdd:COG2223 162 FLILGILLLVVAVLAWLFLrdppAGAAAAAKASLRDQLEALRDPR-FWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSA 240
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 446474088 252 KLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLL 309
Cdd:COG2223 241 ATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLF 298
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
20-390 |
1.78e-08 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 55.65 E-value: 1.78e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLT--DEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGdRKKLIVFCCVLGMLACV 97
Cdd:cd17474 1 LYAVFFATLLAVLGVSIVDPILPAiaEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFG-RKKVLLPGLLLFGIGGL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 98 LFAWNRNYFILLFI----GVFLSSFGSTANPQMFALAREHAdrtgREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFT 173
Cdd:cd17474 80 LCGLSDSFALLLAGralqGIGAAGLGPLALTLIGDLFEGGE----RAKAM--GLYEAALGLGIAVGPLLGGLLAAISWRY 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 174 VMYLSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPR---RNRRDTLLLFVICTLMWGTnSLYIINMPLFIINELHLP 250
Cdd:cd17474 154 PFFLLAALIPVAFLAILFLLPEPKEKAKSSSATKLRDLKkalRGRGLLTFLVSAFLYFFLY-FAFLTYLPFLLELLYGIS 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 251 EKLAGVMMGTAAGLeipTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYF 330
Cdd:cd17474 233 PIIIGLLFAGWSVL---LALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLL 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446474088 331 QDLMPGQA-----GSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLARI 390
Cdd:cd17474 310 TTLVTELApeeerGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
210-389 |
2.04e-08 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 55.37 E-value: 2.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 210 APRRNRRDTLLLFVICTLMWGTNSLYIINMPLfIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAV 289
Cdd:COG2814 4 TPRRRWLALLALALGAFLSGLGIGIVLPALPL-IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 290 VAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPG-QAGSATTLYTNTIRVGWIIAGSLAGIAAEIWN 368
Cdd:COG2814 83 LLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPeRRGRALGLLGAGLGLGPALGPLLGGLLADLFG 162
|
170 180
....*....|....*....|.
gi 446474088 369 YHAVFWFALVMIVATMFCLAR 389
Cdd:COG2814 163 WRWVFLVNAVLALLALLLLLR 183
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
63-388 |
1.91e-07 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 52.58 E-value: 1.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 63 IGIIVSQFLAGR-SDKKGdRKKLIVFCCVLGMLACVLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADrtGREA 141
Cdd:cd17320 45 LGFALGQLLYGPlSDRFG-RRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYS--GAEL 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 142 VMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCSVMVWFFLPSMR---KDAPLATGTLEAPRRNRRDT 218
Cdd:cd17320 122 AKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLALLGLLLLLLVLLFLPETLpeeKRKPLLSSLLRAYKRVLKNR 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 219 LLLF--VICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLM-----CIAVVA 291
Cdd:cd17320 202 RFLGyaLALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLrlgllLLLAAA 281
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 292 GLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQAGSATTLYtNTIRVGwiIAGSLAGIAAEIWNyHA 371
Cdd:cd17320 282 LVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHVAGTASALL-GFLQFL--IGALAGALVGLLPN-GT 357
|
330
....*....|....*..
gi 446474088 372 VFWFALVMIVATMFCLA 388
Cdd:cd17320 358 ALPMGLLILVLGLLALL 374
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-388 |
2.23e-07 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 52.22 E-value: 2.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTdevharpgmvgFFFTGSAVIGIIVSQFLAGR-SDKKGDRKKLI--VFCCVLGMLAC 96
Cdd:cd17316 15 FFLIGFVAPVLAAEFSLGLSLLQT-----------GLLFAAGFLGRPIGALLFGYlGDRIGRKKALIltLLLFGLATLLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 97 vLFAWNrnyFILLFIGVFLSSFGSTA-NPQMFALAREHADRTGReavmfsSILRAQVSLAWVIGPPLAYALAMGFS-FTV 174
Cdd:cd17316 84 -GLLPT---PILLLVLRFLQGIGIGGeYPGASTYVAEFAPSKRR------GFALGLLQSGWALGALLAALVASLLIpLLS 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 175 MYLSAAVAFIVCSVMVWFFLPSmrkdaplatgtleaprrnRRDTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLA 254
Cdd:cd17316 154 GDWGWRILFLIGALPALLALLL------------------RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATS 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 255 GVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYA--GMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQD 332
Cdd:cd17316 216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAE 295
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446474088 333 LMPGQA-GSATTLYTNTIRVGWIIAGSLAG-IAAEIWNYHAVFWFALVMIVATMFCLA 388
Cdd:cd17316 296 LFPTEVrATGVGLSYNLGRLGGGGAPPLIAlLLASTGGTGVPALILALLAIVALIVAL 353
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
221-392 |
8.46e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 50.49 E-value: 8.46e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 221 LFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGML 300
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 301 LAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQA-GSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVM 379
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEErGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170
....*....|...
gi 446474088 380 IVATMFCLARIKD 392
Cdd:pfam07690 161 SLLAAVLLLLPRP 173
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
22-384 |
8.61e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 8.61e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 22 IVAFLTGIAGALQTPTLSIFLTdEVHARPGMVGFFFTGSAVIGIIVSqFLAGR-SDKKGDRKKLIVFCCVLGMLACVLFA 100
Cdd:cd17370 6 LVSLFADISYEMARSILPLFLV-VLGASAAAVGLIEGLAEALGSLLR-LFSGYlSDRTGKRKPLVILGYGLSALAKPLLA 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 101 WNrNYFILLFIGVFLSSFGSTA-NPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYAL--AMGFSF-TVMY 176
Cdd:cd17370 84 LA-GSWQLVLLLRILERLGKGIrTPPRDALLADATPPSGRGKAF--GLHRALDTLGAVLGPLLAALLlyLLGGNYrTIFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 177 LSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFVICTLMWGTNSLYIinMPLFIINELHLPEKLAGV 256
Cdd:cd17370 161 LAAIPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFA--FLILRAQELGLSAALIPL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 257 MMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPG 336
Cdd:cd17370 239 LYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVPA 318
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446474088 337 QA-GSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATM 384
Cdd:cd17370 319 ELrGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIAL 367
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
5-390 |
1.94e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 49.49 E-value: 1.94e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 5 PAAAAPKSFDLTSTAFLIVAFLTGIAGALQTPTLSI-----FLTDEVHARPGMVGFFFTgSAVIGIIVSQFLAGRSDKKG 79
Cdd:COG2807 2 STTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVgpllpEIRADLGLSATQAGLLTT-LPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 80 DRKKLIVFCCVLGMLACVLFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREH-ADRTGREAVMFSSILraqvSLAWVI 158
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWfPDRVGLMTGLYTAAM----GLGAAL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 159 GPPLAYALAMGFSFTVMYLSAAVaFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFVicTLMWGTNSL--YI 236
Cdd:COG2807 157 AAGLTVPLAAALGWRGALAVWAL-LALLALLLWLPLLRRRPAAAAAAPAAASLRSLWRSPLAWLL--TLFFGLQSLlyYA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 237 IN--MPLFIInELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLG-KRLLMCIAVVAGLCFYAGMLLAHAPATLLGLQL 313
Cdd:COG2807 234 VVawLPPILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGdRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 314 LNAIYIGILGGIGMLyFQDLMPGQAGSAtTLYTNTIRVGWIIAGS---LAGIAAEIW-NYHAVFWFALVMIVATMFCLAR 389
Cdd:COG2807 313 LGLGQGGLFPLALTL-IGLRARTPAEAA-ALSGMAQSVGYLLAALgplLVGALHDATgSWTAALLLLAALAVLMLVAGLL 390
|
.
gi 446474088 390 I 390
Cdd:COG2807 391 A 391
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
19-194 |
2.28e-06 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 49.17 E-value: 2.28e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVL 98
Cdd:cd17388 210 GLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLL 289
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 99 FAWNRNYFiLLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALamgFSFTVMYLS 178
Cdd:cd17388 290 LAFATQGW-MVFPILILLALGGIAGPALQGLLSRQVPENEQGELQ--GVLTSLTSLTSIIGPLLFTGI---FAASPATWP 363
|
170 180
....*....|....*....|..
gi 446474088 179 ------AAVAFIVCSVMVWFFL 194
Cdd:cd17388 364 glawiiGAALYLICLVLAYRFF 385
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
21-309 |
3.66e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 48.42 E-value: 3.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIFLTDEVHAR---PGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKkLIVFCCVLGMLACV 97
Cdd:cd17355 5 LAVTFLILILSWGIRYYFGVFIIPIIAEFgwsRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRR-VMLLGLLLLAAGLV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 98 LFAWNRNY--FILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVmfsSILRAQVSLAWVIGPPLAYALAMGFSFTVM 175
Cdd:cd17355 84 LLALATSLwqLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRRGLAL---GILTAGGGLGSLVFLPLGAALIEAFGWRTA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 176 YLSAAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNR-------RDTLLLFVICTLMWGTNSLYIINMPLFI-INEL 247
Cdd:cd17355 161 LLVLALLALLVLVPVLLLLRRRPADLALRAYDDASPASPGstlkealRSASFWLLALAFFLCGFAVVGLIVHLVPyLADR 240
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446474088 248 HLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPATLL 309
Cdd:cd17355 241 GISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLAL 302
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
36-389 |
5.16e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.00 E-value: 5.16e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 36 PTLSIFLTDEVHARPGMVGFFfTGSAVIGIIVSQFLAGR-SDKKGDRKKLIVFCCVLGMLACvLFAWNRNYFILLFIGVF 114
Cdd:cd17475 16 PALAPFLQEDLHLSLAQVGLL-LSALNLGVAVSMLPAGWlLDRFGERRVLAVGLLLMGAAAL-LMALVGSYPVLLVLLFL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 115 LSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCSVMVWFFL 194
Cdd:cd17475 94 VGAGYGSVQPGGGRAIMRWFPPRERGLAM--GIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFY 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 195 ---PSMRKDAPLAT---GTLEAPRRNrRDTLLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPT 268
Cdd:cd17475 172 repPAASAATESAStllRSLKEVLRN-RDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAAGALLAVAQLGGALG 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 269 MLIAGYFAKRLGK---RLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLM----PGQAGSA 341
Cdd:cd17475 251 RIGLGRVSDRVFGgrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIGWNGLYLTLVAesagPEQAGTA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 446474088 342 TTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMFCLAR 389
Cdd:cd17475 331 LGLANTINFIGIAIGPPLFGLLVDATHSYAPAWLALALLLVLAALLLL 378
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
220-392 |
1.02e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.19 E-value: 1.02e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 220 LLFVICTLMWGTnSLYIINMPLFIiNELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGM 299
Cdd:cd17325 1 LSLALFLDMLGY-GIIIPILPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLF 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 300 LLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMP-GQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALV 378
Cdd:cd17325 79 AFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAA 158
|
170
....*....|....
gi 446474088 379 MIVATMFCLARIKD 392
Cdd:cd17325 159 LALLALVLALLLLP 172
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
227-393 |
1.33e-05 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 46.82 E-value: 1.33e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 227 LMWGTNSLYIINMPLFIInELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGMLLAHAPA 306
Cdd:cd17489 7 FFFLSFYLLLPVLPLYAH-DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 307 TLLGLQLLNAIYIGILGGIGMLYFQDLMPGQ-AGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMF 385
Cdd:cd17489 86 LLLVLRLIHGIGWGAFTTAAATLVADIIPPSrRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALL 165
|
....*...
gi 446474088 386 CLARIKDV 393
Cdd:cd17489 166 LVFLVKDP 173
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
20-191 |
3.12e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 45.50 E-value: 3.12e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLF 99
Cdd:cd06174 208 LLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALL 287
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLA-YALAMGFSFTVMYLS 178
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF--GLLNTFGFLGGAIGPLLAgFLLAATFGLTGAFLV 365
|
170
....*....|...
gi 446474088 179 AAVAFIVCSVMVW 191
Cdd:cd06174 366 LAVLLLLAAILLL 378
|
|
| MFS_1_like |
pfam12832 |
MFS_1 like family; This family contains proteins related to the MFS superfamily. |
25-340 |
4.88e-05 |
|
MFS_1 like family; This family contains proteins related to the MFS superfamily.
Pssm-ID: 432817 [Multi-domain] Cd Length: 362 Bit Score: 44.93 E-value: 4.88e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 25 FLTGIAGALQtPTLSIFLTDeVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGML--ACVLFAWN 102
Cdd:pfam12832 10 FYFAALGCLL-PYWGLYLRS-IGLNPSEIGLITAILPLTRILAPPIWGWLADRTGKRKAVVRLASILAAVlfLSVLFIPI 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 103 RNYFILLFIGVFLSS-FGSTANPQMFALAREHadrTGREAVMFSSIlRAQVSLAWVIGPPLAYALAMGFSFTVMY---LS 178
Cdd:pfam12832 88 SLTFWWLALLVVLFSfFWNAILPQFEVATLQH---LGEKRKDYGRQ-RLWGSVGFALSVFGLGALFDHYSVGLLPsvlFY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 179 AAVAFIVCSVMVWFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFVICTLMwgTNSLYIINMPLFI-INELHLPEKLAGVM 257
Cdd:pfam12832 164 LFAALMLLSLLLPLAPPEMEYESKGGSKAVFWNLLKQPEVIIFFLAAFLL--GFSHGPFYTFLFLyLENLGASNTLLGAL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 258 MGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAG---LCFYAgmLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLM 334
Cdd:pfam12832 242 WALGVVAEIPLFFYAHRLLRRFGHRNLLIIALLLTalrWLLYA--FFVENPWLVLPIQFLHAISFGLTHAAAIEYVRRIF 319
|
....*.
gi 446474088 335 PGQAGS 340
Cdd:pfam12832 320 PGSLQG 325
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
54-194 |
1.10e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 43.74 E-value: 1.10e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 54 GFFFTGSAvIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFaWNRNYFILLFIGVFLSSFG-STANPQMFALARE 132
Cdd:cd17489 230 GLFFTVYA-IALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLL-SFAGSPWMLLLAAVLYGLGfGLLFPALQALAVD 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446474088 133 HADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYLSAAVAFIVCSVMVWFFL 194
Cdd:cd17489 308 LVPPHRRGAAN--GTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
19-199 |
1.71e-04 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 43.32 E-value: 1.71e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 19 AFLIVAFLTGIAGALQTpTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKK-LIVFCCVLGMLACV 97
Cdd:COG2271 185 LALAYFLVYFALYGFLT-WLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKlVLAIGLLLAALALL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 98 LFAWNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAMGFSFTVMYL 177
Cdd:COG2271 264 LLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTAS--GLVNTFGFLGGALGPLLVGYLLDATGYQAAFL 341
|
170 180
....*....|....*....|..
gi 446474088 178 SAAVAFIVCSVMVWFFLPSMRK 199
Cdd:COG2271 342 LLAALALLAALLALLLLRETRK 363
|
|
| MFS_MFSD3 |
cd17485 |
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily ... |
270-385 |
1.74e-04 |
|
Major facilitator superfamily domain containing 3 protein; Major facilitator superfamily domain containing 3 protein (MFSD3) is a predicted acetyl-CoA transporter. As an atypical putative membrane-bound solute carrier (SLC), MFSD3 is most likely to be functionally active in the plasma membrane and not in any intracellular organelles. MFSD3 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341038 [Multi-domain] Cd Length: 386 Bit Score: 43.37 E-value: 1.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 270 LIAGYFAKRLGKR---LLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLM----PGQAGSAT 342
Cdd:cd17485 261 LLGGYLLKRRGRRrllLLGGLLRLLLLGLYTLLALGGSGLNWVLLLASLALLHLVGGMITTALFTLMMdcsqQAQAGTDY 340
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446474088 343 TLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMF 385
Cdd:cd17485 341 TLLATVEVLGKLLFGSLAGFLADHLGYAAAFLLFAILSALSVL 383
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
220-315 |
1.14e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 40.67 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 220 LLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAGM 299
Cdd:cd17329 3 VLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALL 82
|
90
....*....|....*.
gi 446474088 300 LLAHAPATLLGLQLLN 315
Cdd:cd17329 83 GFAHSPWLFAIALVLT 98
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
21-305 |
1.70e-03 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 40.25 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAvIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFA 100
Cdd:cd17473 5 LLASTLTVMAGAAIAPALPAIAQHFVPNSELLVPLLLTLPA-LFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 101 WNRNYFILLFIGVFLSSFGSTANPQMFALAREHADRTGREAVMfsSILRAQVSLAWVIGPPLAYALAmGFSFTVMYLSAA 180
Cdd:cd17473 84 FLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKML--GLQSAAMSLGGVVFLLLGGALA-EIGWRAPFLVYL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 181 VAFIVcSVMVWFFLPSMRKDAPLATGTLEAPRRnRRDTLLLFVICTLMWGTNSLY---IINMPLFIINELHLPEKLAGVM 257
Cdd:cd17473 161 LALPV-LILVLLFLPEPARKSKSAASPGAATAA-ALPWKRVLPIYFLAFLAMLLFyviPIQLPFLLQERGGGSAALIGLA 238
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446474088 258 MGTAAGleipTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAG--MLLAHAP 305
Cdd:cd17473 239 LAIASL----AGAIGALLFGRLKRRLGKRRLLAIGFALMALgfLLLALAS 284
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
157-314 |
3.04e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 39.51 E-value: 3.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 157 VIGPPLAYALAMGFSFTVMYLSAAVAFIVCSVMVWFFLPS-----------MRKDAPLATGTLEAPRRNR-RDTLLLFVI 224
Cdd:cd17331 136 VVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSntkskrekeakESASPPSVFNLKEILRLLRlPGVAFLLLV 215
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 225 CTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTM-LIAGYFAKRLGKRLLM--CIAVVAGlcfyAGMLL 301
Cdd:cd17331 216 KLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQgLLVGPLTKRFGERSLLklSVALLAI----GYLLL 291
|
170
....*....|...
gi 446474088 302 AHAPATLLGLQLL 314
Cdd:cd17331 292 AFVTTVWQLLVLL 304
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-385 |
4.31e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 38.69 E-value: 4.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 21 LIVAFLTGIAGALQTPTLSIFLTDEvHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFA 100
Cdd:cd17477 2 LLSVALLGLGSGLLLPLLSLRLERE-GVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 101 WNRnyFILLFIGVFLSSFGSTAnpqMFALAR----EHADRTGREAVMfsSILRAQVSLAWVIGPPLAyALAMGFSFTvMY 176
Cdd:cd17477 81 TDS--PWVWFLLRFVMGIGLAG---LFVVSEswlnALATNENRGRVL--GLYSTVLGLGFALGPLLL-ALVGTAGAL-PF 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 177 LSAAVAFIVCSVMVWFflpsMRKDAPLATgtlEAPRRNRRDTL----LLFVICTLMWGTNSLYIINMPLFIInELHLPEK 252
Cdd:cd17477 152 LIAAVLLLLALVPLLL----TRRAAPEIE---EAESISLRRLLriapLALLGAFVAGFLEGAFYSLLPLYGL-RLGLSVA 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 253 LAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLM--CIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYF 330
Cdd:cd17477 224 QAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLlgCALLGALAALLLPLVPGLPLALLVLLFLWGGAAGPLYTLALALAG 303
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446474088 331 QDLMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFALVMIVATMF 385
Cdd:cd17477 304 DRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
20-123 |
4.63e-03 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 38.74 E-value: 4.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDEVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLF 99
Cdd:cd17331 212 LLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVQGLLVGPLTKRFGERSLLKLSVALLAIGYLLL 291
|
90 100
....*....|....*....|....
gi 446474088 100 AWNRNYFILLFIGVFLSSFGSTAN 123
Cdd:cd17331 292 AFVTTVWQLLVLLLPLVIGGSVLY 315
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
221-392 |
4.71e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 221 LFVICTLMWGTNSLYIINMPLFIiNELHLPEKLAGVMMGTAAgleIPTMLI---AGYFAKRLGKRLLMciaVVAGLCFYA 297
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYA-ESLGASLSMIGIILGAYG---ISQMLLripLGILSDRIGKRKLF---IIIGLLFTV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 298 ----GMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVF 373
Cdd:cd17490 74 laslIMILFPSPWGLLIARFLSGIAAATWVSFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPF 153
|
170
....*....|....*....
gi 446474088 374 WFALVMIVATMFCLARIKD 392
Cdd:cd17490 154 LLAALAGVLGFILSLFIKE 172
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
20-388 |
5.57e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 20 FLIVAFLTGIAGALQTPTLSIFLTDeVHARPGMVGFFFTGSAVIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLF 99
Cdd:cd17490 1 FLIIVFLFWFSQYVYVPFLSPYAES-LGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASLIM 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 100 AWNRNyFILLFIGVFLSSFGST---ANPQMFAlAREHADRTGREAVMFSSILRAQVSLAWVIGPPLAYALAMGFSFTVMY 176
Cdd:cd17490 80 ILFPS-PWGLLIARFLSGIAAAtwvSFTVLYA-SYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 177 LSAAVAFIVCsvmvwFFLPSMRKDAPLATGTLEAPRRNRRDTLLLFV--ICTLMWGTN---SLYIINMPLFII----NEL 247
Cdd:cd17490 158 LAGVLGFILS-----LFIKEERREKKPVLTELKELLSVLKDKKLLFFslLAILQQMITfstTFGFTPLIAKQLgassFQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 248 HLpekLAGVMMGTAAgleIPTMLIAGYFAKRLGKR--LLMCIAVVAGLCFYagMLLAHAPATLLGLQLLNAIYIGILGGI 325
Cdd:cd17490 233 GL---LSIIYLLPNA---LASLLSGTLFYKKLGERntIIIGFLLLGAYCFL--IPFAPNLTLLYLLQALNGFGTGILFPL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446474088 326 GM-LYFQDLMPGQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWF-ALVMIVATMFCLA 388
Cdd:cd17490 305 LMsLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFViGVIALLAAILSLA 369
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
219-390 |
5.68e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.68 E-value: 5.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 219 LLLFVICTLMWGTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGKRLLMCIAVVAGLCFYAG 298
Cdd:cd17324 1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 299 MLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMP-GQAGSATTLYTNTIRVGWIIAGSLAGIAAEIWNYHAVFWFAL 377
Cdd:cd17324 81 AALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPpEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIA 160
|
170
....*....|...
gi 446474088 378 VMIVATMFCLARI 390
Cdd:cd17324 161 VLALLAALLLWRL 173
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
53-390 |
9.63e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 37.69 E-value: 9.63e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 53 VGFFFTGSAvIGIIVSQFLAGRSDKKGDRKKLIVFCCVLGMLACVLFAWNRNYFILLFIGVFL----SSFGSTANPQMFA 128
Cdd:cd17333 33 VSVIFSSQN-AGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAglgaGILDTGANTFVGA 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 129 LAREhadrtGREAVMfsSILRAQVSLAWVIGPPLA-YALAMGFSFTVMYL-SAAVAFIVCSVMVWFFLPSMRKDAPLATG 206
Cdd:cd17333 112 LFEE-----SSATRL--NVLHGFFGLGALIGPLIAtSLLTSELSWSWAYLiIGLIYLLLAILILLTLFPELPSARNPQQS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 207 TLEAP----RRNRRDTLLLFVICTLMW-GTNSLYIINMPLFIINELHLPEKLAGVMMGTAAGLEIPTMLIAGYFAKRLGK 281
Cdd:cd17333 185 VGAFSasasRLLRNPSIILGALALFLYvGAETAFSSWVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKP 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446474088 282 RLLMCIAVVAGLCFYAGMLLAHAPATLLGLQLLNAIYIGILGGIGMLYFQDLMPGQAGSATTLYTNTIRVGWIIAGSLAG 361
Cdd:cd17333 265 HTLLVLSGSGALLGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAGSIGGAIIPFIMG 344
|
330 340
....*....|....*....|....*....
gi 446474088 362 IAAEIWNYHAVFWFALVMiVATMFCLARI 390
Cdd:cd17333 345 FIAEAVGIQTAMLLITIL-YAIIFVLALL 372
|
|
| |
