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Conserved domains on  [gi|446465922|ref|WP_000543776|]
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MULTISPECIES: bacteriocin immunity protein [Bacteria]

Protein Classification

bacteriocin immunity protein( domain architecture ID 11611489)

bacteriocin immunity protein, similar to Escherichia coli colicin immunity proteins, which protect against the action of colicins produced by Escherichia coli to outcompete related Escherichia coli bacteria or other members of the Enterobacteriaceae

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Col_Im_like cd16363
inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins; This ...
 11-93 1.66e-33

inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins; This family contains inhibitory immunity (Im) proteins that bind to colicin endonucleases (DNases) or pyocins with very high affinity and specificity; this is critical for the neutralization of endogenous DNase catalytic activity and for protection against exogenous DNase bacteriocins. The DNase colicin family (ColE2, ColE7, ColE8 and ColE9) in E. coli, and pyocin family (S1, S2, S3 and AP41) in P. aeruginosa, are potent bacteriocins where the immunity proteins (Ims) protect the colicin/pyocin producing (i.e. colicinogenic) bacteria by binding and inactivating colicin nucleases. The binding affinities between cognate and non-cognate nucleases by Im proteins can vary up to 10 orders of magnitude.


:

Pssm-ID: 319897  Cd Length: 81  Bit Score: 110.68  E-value: 1.66e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465922 11 YTEGEFLEMLEEIVNATSKDkslkgkklEKYLDTLVDHFIKITEHPKKGDLIFYPNSQEDGEPENILKIVKEWRRSQGLP 90
Cdd:cd16363   7 YTESEFLELVEEIFNADYGS--------EEELDDLLDHFEKITEHPAGSDLIFYPEDGADDSPEGIVEEVKEWRAANGLP 78


                ...
gi 446465922 91 LFK 93
Cdd:cd16363  79 GFK 81
 
Name Accession Description Interval E-value
Col_Im_like cd16363
inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins; This ...
 11-93 1.66e-33

inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins; This family contains inhibitory immunity (Im) proteins that bind to colicin endonucleases (DNases) or pyocins with very high affinity and specificity; this is critical for the neutralization of endogenous DNase catalytic activity and for protection against exogenous DNase bacteriocins. The DNase colicin family (ColE2, ColE7, ColE8 and ColE9) in E. coli, and pyocin family (S1, S2, S3 and AP41) in P. aeruginosa, are potent bacteriocins where the immunity proteins (Ims) protect the colicin/pyocin producing (i.e. colicinogenic) bacteria by binding and inactivating colicin nucleases. The binding affinities between cognate and non-cognate nucleases by Im proteins can vary up to 10 orders of magnitude.


Pssm-ID: 319897  Cd Length: 81  Bit Score: 110.68  E-value: 1.66e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465922 11 YTEGEFLEMLEEIVNATSKDkslkgkklEKYLDTLVDHFIKITEHPKKGDLIFYPNSQEDGEPENILKIVKEWRRSQGLP 90
Cdd:cd16363   7 YTESEFLELVEEIFNADYGS--------EEELDDLLDHFEKITEHPAGSDLIFYPEDGADDSPEGIVEEVKEWRAANGLP 78


                ...
gi 446465922 91 LFK 93
Cdd:cd16363  79 GFK 81
Colicin_Pyocin pfam01320
Colicin immunity protein / pyocin immunity protein;
4-93 8.27e-27

Colicin immunity protein / pyocin immunity protein;


Pssm-ID: 396057  Cd Length: 82  Bit Score: 93.54  E-value: 8.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465922   4 LKYKIYFYTEGEFLEMLEEIVNATSKdkslkgkkLEKYLDTLVDHFIKITEHPKKGDLIFYPNSQEDGEPENILKIVKEW 83
Cdd:pfam01320  1 LKNKLEDYTEAEFLAFVKKIFEANFG--------TESEEDSLVLHFEKITEHPSGSDLIFYPEDGEEDSPEGILKEIKEW 72

                         90
                 ....*....|
gi 446465922  84 RRSQGLPLFK 93
Cdd:pfam01320 73 RASNGKPGFK 82
 
Name Accession Description Interval E-value
Col_Im_like cd16363
inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins; This ...
 11-93 1.66e-33

inhibitory immunity (Im) protein of colicin (Col) deoxyribonuclease (DNase) and pyocins; This family contains inhibitory immunity (Im) proteins that bind to colicin endonucleases (DNases) or pyocins with very high affinity and specificity; this is critical for the neutralization of endogenous DNase catalytic activity and for protection against exogenous DNase bacteriocins. The DNase colicin family (ColE2, ColE7, ColE8 and ColE9) in E. coli, and pyocin family (S1, S2, S3 and AP41) in P. aeruginosa, are potent bacteriocins where the immunity proteins (Ims) protect the colicin/pyocin producing (i.e. colicinogenic) bacteria by binding and inactivating colicin nucleases. The binding affinities between cognate and non-cognate nucleases by Im proteins can vary up to 10 orders of magnitude.


Pssm-ID: 319897  Cd Length: 81  Bit Score: 110.68  E-value: 1.66e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465922 11 YTEGEFLEMLEEIVNATSKDkslkgkklEKYLDTLVDHFIKITEHPKKGDLIFYPNSQEDGEPENILKIVKEWRRSQGLP 90
Cdd:cd16363   7 YTESEFLELVEEIFNADYGS--------EEELDDLLDHFEKITEHPAGSDLIFYPEDGADDSPEGIVEEVKEWRAANGLP 78


                ...
gi 446465922 91 LFK 93
Cdd:cd16363  79 GFK 81
Colicin_Pyocin pfam01320
Colicin immunity protein / pyocin immunity protein;
4-93 8.27e-27

Colicin immunity protein / pyocin immunity protein;


Pssm-ID: 396057  Cd Length: 82  Bit Score: 93.54  E-value: 8.27e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465922   4 LKYKIYFYTEGEFLEMLEEIVNATSKdkslkgkkLEKYLDTLVDHFIKITEHPKKGDLIFYPNSQEDGEPENILKIVKEW 83
Cdd:pfam01320  1 LKNKLEDYTEAEFLAFVKKIFEANFG--------TESEEDSLVLHFEKITEHPSGSDLIFYPEDGEEDSPEGILKEIKEW 72

                         90
                 ....*....|
gi 446465922  84 RRSQGLPLFK 93
Cdd:pfam01320 73 RASNGKPGFK 82
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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