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Conserved domains on  [gi|446465128|ref|WP_000542982|]
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MULTISPECIES: cupin domain-containing protein [Salmonella]

Protein Classification

cupin domain-containing protein( domain architecture ID 10007407)

cupin domain-containing protein, part of a functionally diverse superfamily with the active site generally located at the center of a conserved domain forming a beta-barrel fold

CATH:  2.60.120.10
Gene Ontology:  GO:0046872
PubMed:  19478949|14697267|9573603
SCOP:  3001825

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
4-114 2.94e-27

Predicted enzyme of the cupin superfamily [General function prediction only];


:

Pssm-ID: 442673  Cd Length: 108  Bit Score: 96.97  E-value: 2.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465128   4 FKLNQPVPELQPVGSVSLLgalptEGDPQVAVAMIYGKPEDVFTCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQE 83
Cdd:COG3450    1 LDADAVEPESDPPAPERIL-----EGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGE 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446465128  84 PIRFSPGDSWFVEQGTEVAWKVLTPrFVKHY 114
Cdd:COG3450   76 PVEFGAGDSFVFPAGFKGTWEVLET-VRKHY 105
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
4-114 2.94e-27

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 96.97  E-value: 2.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465128   4 FKLNQPVPELQPVGSVSLLgalptEGDPQVAVAMIYGKPEDVFTCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQE 83
Cdd:COG3450    1 LDADAVEPESDPPAPERIL-----EGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGE 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446465128  84 PIRFSPGDSWFVEQGTEVAWKVLTPrFVKHY 114
Cdd:COG3450   76 PVEFGAGDSFVFPAGFKGTWEVLET-VRKHY 105
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 40-114 1.64e-22

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 83.88  E-value: 1.64e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446465128   40 GKPEDVFTCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQEPIRFSPGDSWFVEQGTEVAWKVLTPrFVKHY 114
Cdd:pfam05899   1 LSPLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVTPEGGKTVTLRAGDLVVLPKGLSGTWDVLET-VRKHY 74
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 47-114 1.65e-13

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 60.67  E-value: 1.65e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446465128  47 TCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQEPIRFSPGDSWFVEQGTEVAWKVLTP-RfvKHY 114
Cdd:cd02227    1 SWGIWECTPGKFPWNYDEDEFCYILEGEVRVTPEDGEPVTFKAGDLVVFPAGFSGTWEVLEPvR--KHY 67
 
Name Accession Description Interval E-value
COG3450 COG3450
Predicted enzyme of the cupin superfamily [General function prediction only];
4-114 2.94e-27

Predicted enzyme of the cupin superfamily [General function prediction only];


Pssm-ID: 442673  Cd Length: 108  Bit Score: 96.97  E-value: 2.94e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446465128   4 FKLNQPVPELQPVGSVSLLgalptEGDPQVAVAMIYGKPEDVFTCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQE 83
Cdd:COG3450    1 LDADAVEPESDPPAPERIL-----EGDPSARTWNLFTSPDGGVSAGVWECTPGKFRWDYDEDEFCYILEGRVTVTDDDGE 75

                         90       100       110
                 ....*....|....*....|....*....|.
gi 446465128  84 PIRFSPGDSWFVEQGTEVAWKVLTPrFVKHY 114
Cdd:COG3450   76 PVEFGAGDSFVFPAGFKGTWEVLET-VRKHY 105
Cupin_3 pfam05899
EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly ...
 40-114 1.64e-22

EutQ-like cupin domain; This entry represents the cupin domain, with a conserved jelly roll-like beta-barrel fold capable of homodimerization found in bacteria, plant and fungi. It is present in EutQ family from the eut operon, involved in ethanolamine degradation. EutQ is essential during anoxic growth and has acetate kinase activity. The cupin domain from EutQ does not possess the His residues responsible for metal coordination in other classes of cupins. This domain is also found in (S)-ureidoglycine aminohydrolase (UGlyAH) from E.coli, which is involved in the anaerobic nitrogen utilization via the assimilation of allantoin. It catalyzes the deamination of allantoin to produce S-ureidoglycolate and ammonia from S-ureidoglycine.


Pssm-ID: 399116 [Multi-domain]  Cd Length: 74  Bit Score: 83.88  E-value: 1.64e-22
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446465128   40 GKPEDVFTCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQEPIRFSPGDSWFVEQGTEVAWKVLTPrFVKHY 114
Cdd:pfam05899   1 LSPLGVFSWGIWECTPGKFRWTYEEDETCYILSGEVTVTPEGGKTVTLRAGDLVVLPKGLSGTWDVLET-VRKHY 74
cupin_TM1112-like cd02227
Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial ...
 47-114 1.65e-13

Thermotoga maritima TM1112 and related proteins, cupin domain; This family includes bacterial and plant proteins homologous to TM1112, a Thermotoga maritima protein of unknown function with a cupin beta barrel domain. TM1112 (also known as DUF861) is a subfamily of RmlC-like cupins with a conserved "jelly roll-like" beta-barrel fold; structures indicate that a monomer is the biologically-relevant form.


Pssm-ID: 380356 [Multi-domain]  Cd Length: 69  Bit Score: 60.67  E-value: 1.65e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446465128  47 TCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQEPIRFSPGDSWFVEQGTEVAWKVLTP-RfvKHY 114
Cdd:cd02227    1 SWGIWECTPGKFPWNYDEDEFCYILEGEVRVTPEDGEPVTFKAGDLVVFPAGFSGTWEVLEPvR--KHY 67
cupin_EutQ cd02228
Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial ...
 46-112 4.83e-07

Clostridium difficile EutQ and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to ethanolamine utilization protein EutQ found in Clostridium difficile, as well as in other bacteria, including the enteric pathogens Salmonella enterica and Enterococcus faecalis. EutQ is encoded by the eutQ gene which is part of the eut (ethanolamine utilization) operon found to be essential during anoxic growth of S. enterica on ethanolamine and tetrathionate. In C. difficile, inability to utilize ethanolamine results in greater virulence and a shorter time to morbidity in the animal model, suggesting that, in contrast to other intestinal pathogens, the metabolism of ethanolamine can delay the onset of disease. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization. In contrast to the metal-binding catalytic cupins, the EutQ family does not possess the histidine residues that are responsible for metal coordination in the oxidoreductase and epimerase classes of cupins.


Pssm-ID: 380357 [Multi-domain]  Cd Length: 84  Bit Score: 44.42  E-value: 4.83e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446465128  46 FTCGLFSSTRGGFTMIYPFTEHATVLEGEVELTVAGQEpIRFSPGDSWFVEQGTEVAWKvlTPRFVK 112
Cdd:cd02228   15 MSAGFMELEKKSFPWTLTYDEIKYVLEGELEITDDGQT-VTAKPGDVLFIPKGSKITFS--TPDYAK 78
cupin_BLL4011-like cd02235
Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes ...
 66-99 8.23e-05

Bradyrhizobium diazoefficiens BLL4011 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLL4011, a Bradyrhizobium diazoefficiens protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380363 [Multi-domain]  Cd Length: 100  Bit Score: 38.71  E-value: 8.23e-05
                         10        20        30
                 ....*....|....*....|....*....|....
gi 446465128  66 EHATVLEGEVELTVAGQEPIRFSPGDSWFVEQGT 99
Cdd:cd02235   41 ESGYVLEGSLELEVDGQPPVTLKAGDSFFIPAGT 74
cupin_BLR7677-like cd02234
Bradyrhizobium japonicum BLR7677 and related proteins, cupin domain; This family includes ...
 68-94 5.92e-04

Bradyrhizobium japonicum BLR7677 and related proteins, cupin domain; This family includes bacterial and fungal proteins homologous to BLR7677, a Bradyrhizobium japonicum protein of unknown function. Proteins in this family belong to the cupin superfamily with a conserved "jelly roll-like" beta-barrel fold capable of homodimerization.


Pssm-ID: 380362 [Multi-domain]  Cd Length: 103  Bit Score: 36.71  E-value: 5.92e-04
                         10        20
                 ....*....|....*....|....*..
gi 446465128  68 ATVLEGEVELTVAGQEPIRFSPGDSWF 94
Cdd:cd02234   43 AYVLEGEVRSQVNGGPPRVYKAGESFY 69
QdoI COG1917
Cupin domain protein related to quercetin dioxygenase [General function prediction only];
63-113 6.40e-04

Cupin domain protein related to quercetin dioxygenase [General function prediction only];


Pssm-ID: 441521 [Multi-domain]  Cd Length: 99  Bit Score: 36.37  E-value: 6.40e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446465128  63 PFTEHATVLEGEVELTVaGQEPIRFSPGDSWFVEQGTEVAWKVLTPRFVKH 113
Cdd:COG1917   42 PGEELIYVLEGEGEVEV-GGEEYELKPGDVVFIPPGVPHAFRNLGDEPAVL 91
Cupin_2 pfam07883
Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ( ...
 65-100 1.88e-03

Cupin domain; This family represents the conserved barrel domain of the 'cupin' superfamily ('cupa' is the Latin term for a small barrel).


Pssm-ID: 462300 [Multi-domain]  Cd Length: 71  Bit Score: 34.54  E-value: 1.88e-03
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 446465128   65 TEHATVLEGEVELTVAGQEpIRFSPGDSWFVEQGTE 100
Cdd:pfam07883  20 DEFFYVLEGEGELTVDGEE-VVLKAGDSVYFPAGVP 54
cupin_RmlC-like cd02208
RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP ...
 66-104 2.51e-03

RmlC-like cupin superfamily; This superfamily contains proteins similar to the RmlC (dTDP (deoxythymidine diphosphates)-4-dehydrorhamnose 3,5-epimerase)-like cupins. RmlC is a dTDP-sugar isomerase involved in the synthesis of L-rhamnose, a saccharide required for the virulence of some pathogenic bacteria. Cupins are a functionally diverse superfamily originally discovered based on the highly conserved motif found in germin and germin-like proteins. This conserved motif forms a beta-barrel fold found in all of the cupins, giving rise to the name cupin ('cupa' is the Latin term for small barrel). The active site of members of this superfamily is generally located at the center of a conserved barrel and usually includes a metal ion. The different functional classes in this superfamily include single domain bacterial isomerases and epimerases involved in the modification of cell wall carbohydrates, two domain bicupins such as the desiccation-tolerant seed storage globulins, and multidomain nuclear transcription factors involved in legume root nodulation.


Pssm-ID: 380338 [Multi-domain]  Cd Length: 73  Bit Score: 34.38  E-value: 2.51e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446465128  66 EHATVLEGEVELTVAGQEPIRFSPGDSWFVEQGTEVAWK 104
Cdd:cd02208   22 EIFYVLSGEGELTLDDGETVELKAGDIVLIPPGVPHSFV 60
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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