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Conserved domains on  [gi|446462983|ref|WP_000540837|]
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MULTISPECIES: TetR/AcrR family transcriptional regulator [Staphylococcus]

Protein Classification

TetR/AcrR family transcriptional regulator( domain architecture ID 11442335)

TetR/AcrR family transcriptional regulator controls genes involved in a variety of processes including antibiotic production, osmotic stress response, efflux pump expression, and multidrug resistance

CATH:  1.10.357.10
Gene Ontology:  GO:0003677|GO:0006355

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-54 8.32e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


:

Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 43.73  E-value: 8.32e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446462983   4 KRKTVLTQRNIKNALVSLLENNKFDFITINQIVEEAEITRSTFYRYYDDKY 54
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKE 51
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 88-179 5.41e-03

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


:

Pssm-ID: 464123  Cd Length: 103  Bit Score: 34.91  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446462983   88 EMFKYLFETLEPYSNTIYRLLGYNGDSSFEMKLKNEISRRFI----DIEQRNHISQVRADLVKEYVFVIMIKTLQYWSAH 163
Cdd:pfam14278   5 EGLLKIFEYIKENKDFYRNLLSSNGRESFERYLYELTKELILgvveELSEGMNVSEEDKDFIADFYSYGFVGLILDWLEN 84

                          90
                  ....*....|....*.
gi 446462983  164 KDEVDIDEIALTIRDI 179
Cdd:pfam14278  85 GMKESPEEIAELLSRL 100
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-54 8.32e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 43.73  E-value: 8.32e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446462983   4 KRKTVLTQRNIKNALVSLLENNKFDFITINQIVEEAEITRSTFYRYYDDKY 54
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKE 51
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 7-54 4.42e-04

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 39.36  E-value: 4.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446462983    7 TVLTQRNIKNALVSLLENNKFDFITINQIVEEAEITRSTFYRYYDDKY 54
Cdd:TIGR02366   1 SIITKKKIAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKY 48
HTH_Tnp_1_2 pfam13022
Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins ...
 4-53 2.00e-03

Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.


Pssm-ID: 404044 [Multi-domain]  Cd Length: 122  Bit Score: 36.71  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446462983    4 KRKTVLTQRNIKNALvsLLENNKFDFITINQIVEEAEITRSTFYRYYDDK 53
Cdd:pfam13022   2 ARKGDLTAKQIKAAE--LLAENDYHTLTKDEIAEELGVSRSTLYKWLRKK 49
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 88-179 5.41e-03

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 34.91  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446462983   88 EMFKYLFETLEPYSNTIYRLLGYNGDSSFEMKLKNEISRRFI----DIEQRNHISQVRADLVKEYVFVIMIKTLQYWSAH 163
Cdd:pfam14278   5 EGLLKIFEYIKENKDFYRNLLSSNGRESFERYLYELTKELILgvveELSEGMNVSEEDKDFIADFYSYGFVGLILDWLEN 84

                          90
                  ....*....|....*.
gi 446462983  164 KDEVDIDEIALTIRDI 179
Cdd:pfam14278  85 GMKESPEEIAELLSRL 100
 
Name Accession Description Interval E-value
AcrR COG1309
DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];
4-54 8.32e-06

DNA-binding protein, AcrR family, includes nucleoid occlusion protein SlmA [Transcription];


Pssm-ID: 440920 [Multi-domain]  Cd Length: 156  Bit Score: 43.73  E-value: 8.32e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446462983   4 KRKTVLTQRNIKNALVSLLENNKFDFITINQIVEEAEITRSTFYRYYDDKY 54
Cdd:COG1309    1 RRRREATRERILDAALELFAEKGYEGTSVRDIAARAGVSKGTLYRHFGSKE 51
DHAK_reg TIGR02366
probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from ...
 7-54 4.42e-04

probable dihydroxyacetone kinase regulator; The seed alignment for this family was built from a set of closely related uncharacterized proteins associated with operons for the type of bacterial dihydroxyacetone kinase that transfers PEP-derived phosphate from a phosphoprotein, as in phosphotransferase system transport, rather than from ATP. Members have a TetR transcriptional regulator domain (pfam00440) at the N-terminus and sequence homology throughout.


Pssm-ID: 274100 [Multi-domain]  Cd Length: 176  Bit Score: 39.36  E-value: 4.42e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 446462983    7 TVLTQRNIKNALVSLLENNKFDFITINQIVEEAEITRSTFYRYYDDKY 54
Cdd:TIGR02366   1 SIITKKKIAKAFKDLMEVQAFHKISVSDIMQTAQIRRQTFYNHFQDKY 48
HTH_Tnp_1_2 pfam13022
Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins ...
 4-53 2.00e-03

Helix-turn-helix of insertion element transposase; This is a family of largely phage proteins which are likely to be a helix-turn-helix insertion elements.


Pssm-ID: 404044 [Multi-domain]  Cd Length: 122  Bit Score: 36.71  E-value: 2.00e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446462983    4 KRKTVLTQRNIKNALvsLLENNKFDFITINQIVEEAEITRSTFYRYYDDK 53
Cdd:pfam13022   2 ARKGDLTAKQIKAAE--LLAENDYHTLTKDEIAEELGVSRSTLYKWLRKK 49
TetR_C_8 pfam14278
Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, ...
 88-179 5.41e-03

Transcriptional regulator C-terminal region; This domain is a tetracycline repressor, domain 2, or C-terminus.


Pssm-ID: 464123  Cd Length: 103  Bit Score: 34.91  E-value: 5.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446462983   88 EMFKYLFETLEPYSNTIYRLLGYNGDSSFEMKLKNEISRRFI----DIEQRNHISQVRADLVKEYVFVIMIKTLQYWSAH 163
Cdd:pfam14278   5 EGLLKIFEYIKENKDFYRNLLSSNGRESFERYLYELTKELILgvveELSEGMNVSEEDKDFIADFYSYGFVGLILDWLEN 84

                          90
                  ....*....|....*.
gi 446462983  164 KDEVDIDEIALTIRDI 179
Cdd:pfam14278  85 GMKESPEEIAELLSRL 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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