NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|446455687|ref|WP_000533542|]
View 

MULTISPECIES: manganese-binding transcriptional regulator MntR [Salmonella]

Protein Classification

manganese-binding transcriptional regulator MntR( domain architecture ID 11485168)

manganese-binding transcriptional regulator MntR, in the presence of manganese, represses the expression of mntH and mntS, and up-regulates the expression of mntP

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-155 5.69e-92

manganese-binding transcriptional regulator MntR;


:

Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 263.41  E-value: 5.69e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687   4 RAGTPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGF 83
Cdd:PRK11050   1 RAGTPTAKKVTQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446455687  84 IQMIPWRGVFLTPEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSQETLDAFLAFTQQHGTS 155
Cdd:PRK11050  81 VEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGAK 152
 
Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-155 5.69e-92

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 263.41  E-value: 5.69e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687   4 RAGTPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGF 83
Cdd:PRK11050   1 RAGTPTAKKVTQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446455687  84 IQMIPWRGVFLTPEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSQETLDAFLAFTQQHGTS 155
Cdd:PRK11050  81 VEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGAK 152
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
31-148 1.25e-43

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 140.34  E-value: 1.25e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687  31 EAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRERHQ 110
Cdd:COG1321    1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446455687 111 IVENFLL-VLGVSPEIARRDAEGMEHHVSQETLDAFLAF 148
Cdd:COG1321   81 LLERFLVeVLGVDWDEAHEEAERLEHVLSDETIERLDAF 119
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 59-150 2.45e-30

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 105.38  E-value: 2.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687    59 DMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRERHQIVENFLL-VLGVSPEIARRDAEGMEHHV 137
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVdVLGVDEEEVHEEAERLEHVL 82

                           90
                   ....*....|...
gi 446455687   138 SQETLDAFLAFTQ 150
Cdd:smart00529  83 SDELEDRLDRFLG 95
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 95-148 3.52e-13

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 60.56  E-value: 3.52e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446455687   95 TPEGEKLAQESRERHQIVENFLL-VLGVSPEIARRDAEGMEHHVSQET---LDAFLAF 148
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVdVLGVDWDEVHEEAERLEHALSDELidrLDEFLGF 58
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 35-95 2.34e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 2.34e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446455687  35 RELIDDYVELISDLIIEVGEA--RQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLT 95
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRlpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
PRK11050 PRK11050
manganese-binding transcriptional regulator MntR;
4-155 5.69e-92

manganese-binding transcriptional regulator MntR;


Pssm-ID: 182927 [Multi-domain]  Cd Length: 152  Bit Score: 263.41  E-value: 5.69e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687   4 RAGTPTTKKVTQLVNVEEHVEGFRQVREAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGF 83
Cdd:PRK11050   1 RAGTPTAKKVTQLVDVEEHVEGFRQVREAHRRELIEDYVELIADLIAEVGEARQVDIAARLGVSQPTVAKMLKRLARDGL 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446455687  84 IQMIPWRGVFLTPEGEKLAQESRERHQIVENFLLVLGVSPEIARRDAEGMEHHVSQETLDAFLAFTQQHGTS 155
Cdd:PRK11050  81 VEMRPYRGVFLTPEGEKLAQESRERHQIVENFLLALGVSPETARRDAEGIEHHVSEETLAAFRRFLQRHGAK 152
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
31-148 1.25e-43

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 140.34  E-value: 1.25e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687  31 EAHRRELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRERHQ 110
Cdd:COG1321    1 MMMLSESEEDYLKAIYELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEYEPYGGITLTEEGRELALRIVRRHR 80

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446455687 111 IVENFLL-VLGVSPEIARRDAEGMEHHVSQETLDAFLAF 148
Cdd:COG1321   81 LLERFLVeVLGVDWDEAHEEAERLEHVLSDETIERLDAF 119
HTH_DTXR smart00529
Helix-turn-helix diphteria tox regulatory element; iron dependent repressor
 59-150 2.45e-30

Helix-turn-helix diphteria tox regulatory element; iron dependent repressor


Pssm-ID: 197774 [Multi-domain]  Cd Length: 95  Bit Score: 105.38  E-value: 2.45e-30
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687    59 DMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRERHQIVENFLL-VLGVSPEIARRDAEGMEHHV 137
Cdd:smart00529   3 EIAERLNVSPPTVTEMLKKLEKMGLVEYEPYRGITLTEKGRRLARRLLRKHRLLERFLVdVLGVDEEEVHEEAERLEHVL 82

                           90
                   ....*....|...
gi 446455687   138 SQETLDAFLAFTQ 150
Cdd:smart00529  83 SDELEDRLDRFLG 95
PRK03902 PRK03902
transcriptional regulator MntR;
39-150 1.47e-24

transcriptional regulator MntR;


Pssm-ID: 179669 [Multi-domain]  Cd Length: 142  Bit Score: 92.37  E-value: 1.47e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446455687  39 DDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRERHQIVENFLLV 118
Cdd:PRK03902   7 EDYIEQIYLLIEEKGYARVSDIAEALSVHPSSVTKMVQKLDKDEYLIYEKYRGLVLTPKGKKIGKRLVYRHELLEQFLRI 86

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446455687 119 LGVSPEIARRDAEGMEHHVSQETLDAFLAFTQ 150
Cdd:PRK03902  87 IGVDESKIYNDVEGIEHHLSWNAIDRIGDLVQ 118
Fe_dep_repr_C pfam02742
Iron dependent repressor, metal binding and dimerization domain; This family includes the ...
 95-148 3.52e-13

Iron dependent repressor, metal binding and dimerization domain; This family includes the Diphtheria toxin repressor. It acts as an iron-binding repressor of diphtheria toxin gene expression and may serve as a global regulator of gene expression. DTXR comprises an N-terminal DNA-binding domain, an interface domain (which contains two metal-binding sites) and a third, very flexible C-terminal domain. The second domain is responsible for dimerization and metal binding. Binding of DTXR to Tox operator requires a divalent metal ion such as cobalt, ferric, manganese and nickel whereas zinc shows weak activation. This domain can also bind Cd(II), Ca(II) and Cu(II) (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).


Pssm-ID: 426954  Cd Length: 69  Bit Score: 60.56  E-value: 3.52e-13
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446455687   95 TPEGEKLAQESRERHQIVENFLL-VLGVSPEIARRDAEGMEHHVSQET---LDAFLAF 148
Cdd:pfam02742   1 TEKGRKIALRVVRRHRLLERFLVdVLGVDWDEVHEEAERLEHALSDELidrLDEFLGF 58
Fe_dep_repress pfam01325
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ...
 36-92 5.76e-09

Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.


Pssm-ID: 396062 [Multi-domain]  Cd Length: 57  Bit Score: 49.68  E-value: 5.76e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446455687   36 ELIDDYVELISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGV 92
Cdd:pfam01325   1 ESTEDYLETIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYVDYEPYKGL 57
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
47-113 6.39e-07

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 45.28  E-value: 6.39e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446455687    47 DLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRG------VFLTPEGEKLAQESRERHQIVE 113
Cdd:smart00347  17 RILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEdrrsvlVSLTEEGRELIEQLLEARSETL 89
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
53-110 7.15e-06

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 43.03  E-value: 7.15e-06
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446455687  53 GEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIP----WRG--VFLTPEGEKLAQESRERHQ 110
Cdd:COG1846   51 GGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPdpedRRAvlVRLTEKGRALLEEARPALE 114
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
 35-95 2.34e-04

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 37.43  E-value: 2.34e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446455687  35 RELIDDYVELISDLIIEVGEA--RQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLT 95
Cdd:cd07377    4 EQIADQLREAILSGELKPGDRlpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
LysR COG0583
DNA-binding transcriptional regulator, LysR family [Transcription];
61-107 3.32e-04

DNA-binding transcriptional regulator, LysR family [Transcription];


Pssm-ID: 440348 [Multi-domain]  Cd Length: 256  Bit Score: 39.46  E-value: 3.32e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446455687  61 AARLGVSQPTVAKMLKRL-ASLGF--IQMIPwRGVFLTPEGEKLAQESRE 107
Cdd:COG0583   22 AERLGVSQPAVSRQIRRLeEELGVplFERTG-RGLRLTEAGERLLERARR 70
YhcF COG1725
DNA-binding transcriptional regulator YhcF, GntR family [Transcription];
59-124 9.22e-04

DNA-binding transcriptional regulator YhcF, GntR family [Transcription];


Pssm-ID: 441331 [Multi-domain]  Cd Length: 114  Bit Score: 37.08  E-value: 9.22e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446455687  59 DMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTPEGEKLAQESRER--HQIVENFL---LVLGVSPE 124
Cdd:COG1725   39 ELAAELGVNPNTVAKAYRELEDEGLIETRRGKGTFVAEDARELLEERREEflEEALRELVaeaRRLGLSLE 109
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 53-85 2.07e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 34.83  E-value: 2.07e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 446455687   53 GEARQVDMAARLGVSQPTVAKMLKRLASLGFIQ 85
Cdd:pfam01047  16 GPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIE 48
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
43-96 2.82e-03

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 36.44  E-value: 2.82e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446455687  43 ELISDLIIEVGEA-RQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVFLTP 96
Cdd:COG1802   22 EAILSGELPPGERlSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAP 76
HTH_1 pfam00126
Bacterial regulatory helix-turn-helix protein, lysR family;
61-99 3.22e-03

Bacterial regulatory helix-turn-helix protein, lysR family;


Pssm-ID: 459683 [Multi-domain]  Cd Length: 60  Bit Score: 34.28  E-value: 3.22e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 446455687   61 AARLGVSQPTVAKMLKRL-ASLG---FIQMIpwRGVFLTPEGE 99
Cdd:pfam00126  20 AERLGLSQPAVSRQIKRLeEELGvplFERTT--RGVRLTEAGE 60
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 49-88 7.30e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 33.33  E-value: 7.30e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446455687   49 IIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFIQMIP 88
Cdd:pfam12802  14 LARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREP 53
LexA COG1974
SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, ...
 43-103 7.54e-03

SOS-response transcriptional repressor LexA (RecA-mediated autopeptidase) [Transcription, Signal transduction mechanisms];


Pssm-ID: 441577 [Multi-domain]  Cd Length: 199  Bit Score: 35.28  E-value: 7.54e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446455687  43 ELISDLIIEVGEA-RQVDMAARLGVSQPTVAKMLKRLASLGFIQMIP--WRGVFLTPEGEKLAQ 103
Cdd:COG1974   13 DFIKEYIRERGYPpSQREIAEALGLSSSAVHRHLKALEKKGYLRRDPgkSRAIELLPASPEVVG 76
HTH_24 pfam13412
Winged helix-turn-helix DNA-binding;
45-84 7.74e-03

Winged helix-turn-helix DNA-binding;


Pssm-ID: 404317 [Multi-domain]  Cd Length: 45  Bit Score: 32.79  E-value: 7.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 446455687   45 ISDLIIEVGEARQVDMAARLGVSQPTVAKMLKRLASLGFI 84
Cdd:pfam13412   6 ILNLLQENPRISQRELAERLGLSPSTVNRRLKRLEEEGVI 45
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
 35-93 9.84e-03

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 32.97  E-value: 9.84e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446455687   35 RELIDDYVELISDLIIEVGEA--RQVDMAARLGVSQPTVAKMLKRLASLGFIQMIPWRGVF 93
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKlpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTF 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH