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Conserved domains on  [gi|446453621|ref|WP_000531476|]
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MULTISPECIES: PTS sugar transporter subunit IIA [Staphylococcus]

Protein Classification

PTS sugar transporter subunit IIA( domain architecture ID 10082877)

PTS sugar transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system, a major carbohydrate active transport system that catalyzes the phosphorylation of incoming sugar substrates, such as mannitol and fructose, concomitantly with their translocation across the cell membrane

CATH:  3.40.930.10
Gene Ontology:  GO:1902495|GO:0009401|GO:0016310|GO:0016301|GO:0008643
PubMed:  11532441|10393270
SCOP:  4001876

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 6-148 3.57e-30

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


:

Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 106.11  E-value: 3.57e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   6 VHKENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVAVLEK 85
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIGNG---IAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446453621  86 EVPFIEMgtldQQTEVKIVFMLAMDKVDDQLKLLQQLMQIFQSEEKLEQILRTKDETILATLI 148
Cdd:cd00211   78 PVDFGSL----DGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
 
Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 6-148 3.57e-30

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 106.11  E-value: 3.57e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   6 VHKENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVAVLEK 85
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIGNG---IAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446453621  86 EVPFIEMgtldQQTEVKIVFMLAMDKVDDQLKLLQQLMQIFQSEEKLEQILRTKDETILATLI 148
Cdd:cd00211   78 PVDFGSL----DGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 4-152 5.46e-28

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 101.08  E-value: 5.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   4 QLVHKENIMLNLSATDKESVLSQMSDVLFQNGFV--KSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVA 81
Cdd:COG1762    5 DLLTPELILLDLEASSKEEAIEELAELLAEKGYVldKEEYLEALLEREELGSTGIGPG---IAIPHARPEGVKKPGIAVA 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446453621  82 VLEKEVPFiemGTLDQQtEVKIVFMLAMDKVDDQLKLLQ--QLMQIFQSEEKLEQILRTKDETILATLINDYL 152
Cdd:COG1762   82 RLKEPVDF---GAMDGE-PVDLVFLLAAPEDDSEEHLKLlaELARLLSDEEFREKLLNAKSPEEILELLKEAE 150
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
5-141 5.24e-24

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 90.73  E-value: 5.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621    5 LVHKENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLpthLCSVAIPHTDVEHINHRTIGVAVLE 84
Cdd:pfam00359   1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI---GNGIAIPHARSEAVKKPGIAVLTLK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446453621   85 KEVPFiemGTLDQQtEVKIVFMLAM-DKVDDQLKLLQQLMQIFQSEEKLEQILRTKDE 141
Cdd:pfam00359  78 EPVDF---GSEDGK-PVKLIFLLAApDNEASHLKILSQLARLLQDEEFVEKLLKAKDP 131
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 5-109 3.98e-19

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 77.70  E-value: 3.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621    5 LVHKENIMLNLSATDKESVLSQMSDVLFQNGFV--KSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVAV 82
Cdd:TIGR00848   1 LLNKDLIFLDQQFTSKEDVIKFLANKLLENGYIsdTEEFLEDLLKREEEGTTGIGDG---VAIPHAKSAAVKQPFVAIAR 77

                          90       100
                  ....*....|....*....|....*..
gi 446453621   83 LEKEVPFiemGTLDQQtEVKIVFMLAM 109
Cdd:TIGR00848  78 LVKGVDW---QSLDGK-PVKLIFLIAV 100
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
15-72 5.01e-07

PTS galactitol transporter subunit IIA;


Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 46.33  E-value: 5.01e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446453621  15 LSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPTHLCSVAIPHTDVEH 72
Cdd:PRK09665  10 ISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIH 67
 
Name Accession Description Interval E-value
PTS_IIA_fru cd00211
PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 6-148 3.57e-30

PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238129 [Multi-domain]  Cd Length: 136  Bit Score: 106.11  E-value: 3.57e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   6 VHKENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVAVLEK 85
Cdd:cd00211    1 LTKENIRLNLKAKSKEEAIEELAQLLVAAGYVEEEYIEALLEREKEGSTGIGNG---IAIPHAKSEAVKKPGIAVLRLKE 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446453621  86 EVPFIEMgtldQQTEVKIVFMLAMDKVDDQLKLLQQLMQIFQSEEKLEQILRTKDETILATLI 148
Cdd:cd00211   78 PVDFGSL----DGQPVHLIFLLAAPDSNEHLKALSQLARLLSDEEFVEQLLNAQSKEEILALL 136
PtsN COG1762
Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate ...
 4-152 5.46e-28

Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 441368 [Multi-domain]  Cd Length: 150  Bit Score: 101.08  E-value: 5.46e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   4 QLVHKENIMLNLSATDKESVLSQMSDVLFQNGFV--KSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVA 81
Cdd:COG1762    5 DLLTPELILLDLEASSKEEAIEELAELLAEKGYVldKEEYLEALLEREELGSTGIGPG---IAIPHARPEGVKKPGIAVA 81

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446453621  82 VLEKEVPFiemGTLDQQtEVKIVFMLAMDKVDDQLKLLQ--QLMQIFQSEEKLEQILRTKDETILATLINDYL 152
Cdd:COG1762   82 RLKEPVDF---GAMDGE-PVDLVFLLAAPEDDSEEHLKLlaELARLLSDEEFREKLLNAKSPEEILELLKEAE 150
PTS_EIIA_2 pfam00359
Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;
5-141 5.24e-24

Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2;


Pssm-ID: 459780 [Multi-domain]  Cd Length: 139  Bit Score: 90.73  E-value: 5.24e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621    5 LVHKENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLpthLCSVAIPHTDVEHINHRTIGVAVLE 84
Cdd:pfam00359   1 LLDKELIFLNLEAKSKEEAIEFLADKLVEAGYVEPAYLEAILEREKEGSTGI---GNGIAIPHARSEAVKKPGIAVLTLK 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 446453621   85 KEVPFiemGTLDQQtEVKIVFMLAM-DKVDDQLKLLQQLMQIFQSEEKLEQILRTKDE 141
Cdd:pfam00359  78 EPVDF---GSEDGK-PVKLIFLLAApDNEASHLKILSQLARLLQDEEFVEKLLKAKDP 131
fruA TIGR00848
PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family ...
 5-109 3.98e-19

PTS system, fructose subfamily, IIA component; 4.A.2 The PTS Fructose-Mannitol (Fru) Family Bacterial PTS transporters transport and concomitantly phosphorylate their sugar substrates, and typically consist of multiple subunits or protein domains. The Fru family is a large and complex family which includes several sequenced fructose and mannitol-specific permeases as well as several putative PTS permeases of unknown specificities. The fructose permeases of this family phosphorylate fructose on the 1-position. Those of family 4.6 phosphorylate fructose on the 6-position. The Fru family PTS systems typically have 3 domains, IIA, IIB and IIC, which may be found as 1 or more proteins. The fructose and mannitol transporters form separate phylogenetic clusters in this family. This model is specific for the IIA domain of the fructose PTS transporters. Also similar to the Enzyme IIA Fru subunits of the PTS, but included in TIGR01419 rather than this model, is enzyme IIA Ntr (nitrogen), also called PtsN, found in E. coli and other organisms, which may play a solely regulatory role. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273298 [Multi-domain]  Cd Length: 129  Bit Score: 77.70  E-value: 3.98e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621    5 LVHKENIMLNLSATDKESVLSQMSDVLFQNGFV--KSTFKDAVIDREKEFATGLPTHlcsVAIPHTDVEHINHRTIGVAV 82
Cdd:TIGR00848   1 LLNKDLIFLDQQFTSKEDVIKFLANKLLENGYIsdTEEFLEDLLKREEEGTTGIGDG---VAIPHAKSAAVKQPFVAIAR 77

                          90       100
                  ....*....|....*....|....*..
gi 446453621   83 LEKEVPFiemGTLDQQtEVKIVFMLAM 109
Cdd:TIGR00848  78 LVKGVDW---QSLDGK-PVKLIFLIAV 100
MtlA2 COG4668
Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and ...
 8-147 1.01e-09

Mannitol/fructose-specific phosphotransferase system, IIA domain [Carbohydrate transport and metabolism];


Pssm-ID: 443705 [Multi-domain]  Cd Length: 143  Bit Score: 53.63  E-value: 1.01e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   8 KENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFAT--GLpthlcSVAIPH---TDVEHINHRTIGVAV 82
Cdd:COG4668    6 KENIRLNASAANKEEAIRLAGQLLVEAGYVEPEYIDAMLEREAQVSTylGN-----GIAIPHgtnEAKDLVLKTGISVLQ 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446453621  83 LEKEVPFIEmgtlDQqtEVKIVFMLAMdKVDDQLKLLQQLMQIFQSEEKLEQILRTKD-ETILATL 147
Cdd:COG4668   81 FPDGVDWGD----GN--TVYLVIGIAA-KSDEHLEILRQLARVLSDEENVEKLAKATDaEEILALL 139
PRK09665 PRK09665
PTS galactitol transporter subunit IIA;
15-72 5.01e-07

PTS galactitol transporter subunit IIA;


Pssm-ID: 182023 [Multi-domain]  Cd Length: 150  Bit Score: 46.33  E-value: 5.01e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446453621  15 LSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPTHLCSVAIPHTDVEH 72
Cdd:PRK09665  10 ISFVDRSEALTHIGNEMLAKGVVHDTYPQALIAREAEFPTGIMLEQHAVAIPHCEAIH 67
PRK15083 PRK15083
PTS system mannitol-specific transporter subunit IICBA; Provisional
 8-71 6.54e-07

PTS system mannitol-specific transporter subunit IICBA; Provisional


Pssm-ID: 237905 [Multi-domain]  Cd Length: 639  Bit Score: 47.74  E-value: 6.54e-07
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446453621   8 KENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEfatgLPTHLC-SVAIPHTDVE 71
Cdd:PRK15083 499 AENIFLGLKAATKEEAIRFAGEQLVKGGYVEPEYVDAMLDREKL----TSTYLGeSIAVPHGTVE 559
PRK09765 PRK09765
PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional
 4-109 1.33e-05

PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional


Pssm-ID: 182066 [Multi-domain]  Cd Length: 631  Bit Score: 43.95  E-value: 1.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446453621   4 QLVHKENIMLNLSATDKESVLSQMSDVLFQNGFV--KSTFKDAVIDREKEFATGLPTHLcsvAIPHTDVEHINHRTIGVA 81
Cdd:PRK09765   5 TLTHRDLLCLNARFTSREEAIHALAQRLAALGKIssTEQFLEEVYRRESLGPTALGEGL---AVPHGKTAAVKEAAFAVA 81

                         90       100
                 ....*....|....*....|....*...
gi 446453621  82 VLEKEvpfIEMGTLDQQTEVKIVFMLAM 109
Cdd:PRK09765  82 TLSEP---LQWEGVDGPEAVDLIFLLAI 106
PRK09913 PRK09913
PTS fructose transporter subunit IIA;
8-78 5.08e-05

PTS fructose transporter subunit IIA;


Pssm-ID: 182141 [Multi-domain]  Cd Length: 148  Bit Score: 41.03  E-value: 5.08e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446453621   8 KENIMLNLSATDKESVLSQMSDVLFQNGFVK--STFKDAVIDREKEFATGLPThlcSVAIPHTDVEHINHRTI 78
Cdd:PRK09913   6 ASCIDLNIQGNGAYSILKQLATIALQNGFITdsHQFLQTLLLREKMHSTGFGS---GVAVPHGKSACVKQPFV 75
PRK13779 PRK13779
bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional
 10-71 1.01e-03

bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional


Pssm-ID: 237502 [Multi-domain]  Cd Length: 503  Bit Score: 38.32  E-value: 1.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446453621  10 NIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPThlcSVAIPHTDVE 71
Cdd:PRK13779   8 NIHLNAQAINKQQAIEMAAAALEQAGNVENGYLQGMLARELQTSTFLGN---GIAIPHGTLD 66
PRK11109 PRK11109
fused PTS fructose transporter subunit IIA/HPr protein;
8-82 3.39e-03

fused PTS fructose transporter subunit IIA/HPr protein;


Pssm-ID: 236849 [Multi-domain]  Cd Length: 375  Bit Score: 36.46  E-value: 3.39e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446453621   8 KENIMLNLSATDKESVLSQMSDVLFQNGFVKSTFKDAVIDREKEFATGLPThlcSVAIPH--TDVEHINHRTiGVAV 82
Cdd:PRK11109   6 VQDIHLGQQAGNKEEAIRQVAAALTQAGNVAEGYVDGMLAREQQTSTFLGN---GIAIPHgtTDTRDLVLKT-GVQV 78
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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