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Conserved domains on  [gi|446444392|ref|WP_000522247|]
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MULTISPECIES: PTS glucose transporter subunit IIA [Bacteria]

Protein Classification

PTS glucose transporter subunit IIA( domain architecture ID 10013238)

PTS glucose transporter subunit IIA is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active transport system that catalyzes the phosphorylation of incoming glucose substrates concomitantly with their translocation across the cell membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 1-169 1.19e-108

PTS system glucose-specific transporter subunit; Provisional


:

Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 306.90  E-value: 1.19e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   1 MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80
Cdd:PRK09439   1 MGFFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVG 160
Cdd:PRK09439  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAG 160


                 ....*....
gi 446444392 161 ETPVIRIKK 169
Cdd:PRK09439 161 ETPVIRVKK 169
 
Name Accession Description Interval E-value
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 1-169 1.19e-108

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 306.90  E-value: 1.19e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   1 MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80
Cdd:PRK09439   1 MGFFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVG 160
Cdd:PRK09439  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAG 160


                 ....*....
gi 446444392 161 ETPVIRIKK 169
Cdd:PRK09439 161 ETPVIRVKK 169
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
16-169 4.33e-71

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 211.14  E-value: 4.33e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  16 KDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGID 95
Cdd:COG2190    1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGID 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446444392  96 TVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKL-SGSVTVGEtPVIRIKK 169
Cdd:COG2190   81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTkSGQVKAGD-PLLTVKL 154
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 23-146 3.29e-62

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 187.88  E-value: 3.29e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  23 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 102
Cdd:cd00210    1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446444392 103 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDE 146
Cdd:cd00210   81 GFTSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 23-143 4.17e-61

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 184.76  E-value: 4.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   23 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 102
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446444392  103 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISN 143
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVVTN 121
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
21-141 2.22e-56

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 172.95  E-value: 2.22e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   21 IEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELK 100
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446444392  101 GEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVI 141
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
 
Name Accession Description Interval E-value
PRK09439 PRK09439
PTS system glucose-specific transporter subunit; Provisional
 1-169 1.19e-108

PTS system glucose-specific transporter subunit; Provisional


Pssm-ID: 181859 [Multi-domain]  Cd Length: 169  Bit Score: 306.90  E-value: 1.19e-108
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   1 MGLFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80
Cdd:PRK09439   1 MGFFDKLKSLVSDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVG 160
Cdd:PRK09439  81 ESDSGVELFVHFGIDTVELKGEGFKRIAEEGQRVKVGDPIIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTAG 160


                 ....*....
gi 446444392 161 ETPVIRIKK 169
Cdd:PRK09439 161 ETPVIRVKK 169
NagE COG2190
Phosphotransferase system IIA component [Carbohydrate transport and metabolism];
16-169 4.33e-71

Phosphotransferase system IIA component [Carbohydrate transport and metabolism];


Pssm-ID: 441793 [Multi-domain]  Cd Length: 154  Bit Score: 211.14  E-value: 4.33e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  16 KDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGID 95
Cdd:COG2190    1 KKSKTLTIYAPVSGEVVPLSEVPDPVFASKMMGDGVAIEPTGGKVVAPVDGTVTSVFPTKHAIGLTSDDGLEVLIHIGID 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446444392  96 TVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKL-SGSVTVGEtPVIRIKK 169
Cdd:COG2190   81 TVKLNGEGFTVLVKEGDKVKAGDPLIEFDLDAIKAAGYSLITPVVVTNSDEYKSVELTkSGQVKAGD-PLLTVKL 154
PTS_IIA_glc cd00210
PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: ...
 23-146 3.29e-62

PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family is one of four structurally and functionally distinct group IIA PTS system cytoplasmic enzymes, necessary for the uptake of carbohydrates across the cytoplasmic membrane and their phosphorylation.


Pssm-ID: 238128 [Multi-domain]  Cd Length: 124  Bit Score: 187.88  E-value: 3.29e-62
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  23 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 102
Cdd:cd00210    1 LASPITGEIVPLDQVPDEVFASKMMGDGFAIKPSDGKVVAPVDGTIVQIFPTKHAIGIESDSGVEILIHIGIDTVKLNGE 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 446444392 103 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDE 146
Cdd:cd00210   81 GFTSHVEEGQRVKQGDKLLEFDLPAIKAAGLDDTTPVIVTNSDE 124
PTBA TIGR00830
PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside ...
 23-143 4.17e-61

PTS system, glucose subfamily, IIA component; These are part of the The PTS Glucose-Glucoside (Glc) SuperFamily. The Glc family includes permeases specific for glucose, N-acetylglucosamine and a large variety of a- and b-glucosides. However, not all b-glucoside PTS permeases are in this class, as the cellobiose (Cel) b-glucoside PTS permease is in the Lac family (TC #4.A.3). The IIA, IIB and IIC domains of all of the permeases listed below are demonstrably homologous. These permeases show limited sequence similarity with members of the Fru family (TC #4.A.2). Several of the PTS permeases in the Glc family lack their own IIA domains and instead use the glucose IIA protein (IIAglc or Crr). Most of these permeases have the B and C domains linked together in a single polypeptide chain, and a cysteyl residue in the IIB domain is phosphorylated by direct phosphoryl transfer from IIAglc(his~P). Those permeases which lack a IIA domain include the maltose (Mal), arbutin-salicin-cellobiose (ASC), trehalose (Tre), putative glucoside (Glv) and sucrose (Scr) permeases of E. coli . Most, but not all Scr permeases of other bacteria also lack a IIA domain. The three-dimensional structures of the IIA and IIB domains of the E. coli glucose permease have been elucidated. IIAglchas a complex b-sandwich structure while IIBglc is a split ab-sandwich with a topology unrelated to the split ab-sandwich structure of HPr. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids, Signal transduction, PTS]


Pssm-ID: 273289 [Multi-domain]  Cd Length: 121  Bit Score: 184.76  E-value: 4.17e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   23 IIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKGE 102
Cdd:TIGR00830   1 IVSPISGEIVPLDQVPDEVFASKIVGDGFAILPTDGKVVAPVDGKIGKIFPTKHAFGIESDNGVEILIHIGIDTVKLNGE 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446444392  103 GFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISN 143
Cdd:TIGR00830  81 GFTSHVEEGDRVKKGDPLLEFDLKAIKKKGYSITTPVVVTN 121
PTS_EIIA_1 pfam00358
phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;
21-141 2.22e-56

phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 1;


Pssm-ID: 459779 [Multi-domain]  Cd Length: 121  Bit Score: 172.95  E-value: 2.22e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392   21 IEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELK 100
Cdd:pfam00358   1 IEIYSPVSGEVIPLSEVPDPVFSQKMMGDGVAIEPSEGKVYAPVDGTVTTVFPTKHAIGITTDDGVEVLIHIGIDTVKLK 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 446444392  101 GEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVI 141
Cdd:pfam00358  81 GEGFESLVKEGDKVKAGDLLLEFDLEAIKAAGYSTTTPVVV 121
PRK10255 PRK10255
PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional
 22-169 1.60e-49

PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional


Pssm-ID: 182338 [Multi-domain]  Cd Length: 648  Bit Score: 168.51  E-value: 1.60e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  22 EIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVHFGIDTVELKG 101
Cdd:PRK10255 500 ELVSPITGDVVALDQVPDEAFASKAVGDGVAVKPTDKIVVSPAAGTIVKIFNTNHAFCLETEKGAEIVVHMGIDTVALEG 579

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446444392 102 EGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKEL-IKLSGSVTVGETPVIRIKK 169
Cdd:PRK10255 580 KGFKRLVEEGAQVSAGQPILEMDLDYLNANARSMISPVVCSNIDDFSGLiIKAQGHVVAGQTPLYEIKK 648
PRK09824 PRK09824
PTS system beta-glucoside-specific transporter subunits IIABC; Provisional
 12-167 1.77e-43

PTS system beta-glucoside-specific transporter subunits IIABC; Provisional


Pssm-ID: 236627 [Multi-domain]  Cd Length: 627  Bit Score: 151.79  E-value: 1.77e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446444392  12 SDDKKDTGTIEIIAPLSGEIVNIEDVPDVVFAEKIVGDGIAIKPTGNKMVAPVDGTIGKIFETNHAFSIESDSGVELFVH 91
Cdd:PRK09824 470 PEVITPPEQGGICSPMTGEVVPLEQVADTTFASGLLGKGIAILPSVGEVRSPVAGRVASLFATLHAIGLESDDGVEVLIH 549

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446444392  92 FGIDTVELKGEGFKRIAEEGQRVKVGDTVIEFDLPLLEEKAKSTLTPVVISNMDEIKELIKLSGSVTVGETPVIRI 167
Cdd:PRK09824 550 VGIDTVKLDGKFFTAHVNVGDKVNTGDLLIEFDIPAIREAGYDLTTPVLISNSDDYTDVLPHATAQVSAGEPLLSI 625
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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