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Conserved domains on  [gi|446435696|ref|WP_000513551|]
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MULTISPECIES: type II toxin-antitoxin system RelE/ParE family toxin [Escherichia]

Protein Classification

type II toxin-antitoxin system RelE/ParE family toxin( domain architecture ID 229520)

type II toxin-antitoxin (TA) system RelE/ParE family toxin similar to Escherichia coli ParE, the toxin component of a TA module involved in involved in plasmid partition; acts by inhibiting DNA gyrase, converting supercoiled plasmid DNA into a singly cleaved linear form in an ATP-dependent fashion

Gene Ontology:  GO:0008657|GO:0042803|GO:0051290|GO:0030541
PubMed:  20143871|26478181|20487277

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG4737 super family cl44118
Uncharacterized conserved protein [Function unknown];
47-97 3.52e-08

Uncharacterized conserved protein [Function unknown];


The actual alignment was detected with superfamily member COG4737:

Pssm-ID: 443771  Cd Length: 123  Bit Score: 47.88  E-value: 3.52e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446435696  47 GGLRKVRMAAGSQGKSGSVRIIYFLATEEIIYLIMAYPKNAKDSLTDTEKA 97
Cdd:COG4737   41 GGVIKKRIARPGRGKSGGYRTIIAYRKGDRAFFLYGFAKNDRANISDDELE 91
 
Name Accession Description Interval E-value
COG4737 COG4737
Uncharacterized conserved protein [Function unknown];
47-97 3.52e-08

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443771  Cd Length: 123  Bit Score: 47.88  E-value: 3.52e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446435696  47 GGLRKVRMAAGSQGKSGSVRIIYFLATEEIIYLIMAYPKNAKDSLTDTEKA 97
Cdd:COG4737   41 GGVIKKRIARPGRGKSGGYRTIIAYRKGDRAFFLYGFAKNDRANISDDELE 91
RelE pfam06296
RelE toxin of RelE / RelB toxin-antitoxin system; RelE is a family of Gram-negative bacterial ...
 18-98 4.68e-06

RelE toxin of RelE / RelB toxin-antitoxin system; RelE is a family of Gram-negative bacterial antitoxins of the RelE/RelB toxin-antitoxin system. Its cognate antitoxin is family RelB, pfam04221.


Pssm-ID: 399359  Cd Length: 120  Bit Score: 42.28  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446435696   18 KQIATDDELKELQKELIGTPDKGDLiqqTGGLRKVRMAAGSQGKSGSVRIIYFLATEEIIYLIMAYPKNAKDSLTDTEKA 97
Cdd:pfam06296  15 KEGISDEELCEAIEEAEQGLIDADL---GGGVIKKRVARPGGGKSGGYRTIVLYRAGERAFFVYGFAKNDRANISDKELA 91


                  .
gi 446435696   98 Q 98
Cdd:pfam06296  92 A 92
 
Name Accession Description Interval E-value
COG4737 COG4737
Uncharacterized conserved protein [Function unknown];
47-97 3.52e-08

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443771  Cd Length: 123  Bit Score: 47.88  E-value: 3.52e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446435696  47 GGLRKVRMAAGSQGKSGSVRIIYFLATEEIIYLIMAYPKNAKDSLTDTEKA 97
Cdd:COG4737   41 GGVIKKRIARPGRGKSGGYRTIIAYRKGDRAFFLYGFAKNDRANISDDELE 91
RelE pfam06296
RelE toxin of RelE / RelB toxin-antitoxin system; RelE is a family of Gram-negative bacterial ...
 18-98 4.68e-06

RelE toxin of RelE / RelB toxin-antitoxin system; RelE is a family of Gram-negative bacterial antitoxins of the RelE/RelB toxin-antitoxin system. Its cognate antitoxin is family RelB, pfam04221.


Pssm-ID: 399359  Cd Length: 120  Bit Score: 42.28  E-value: 4.68e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446435696   18 KQIATDDELKELQKELIGTPDKGDLiqqTGGLRKVRMAAGSQGKSGSVRIIYFLATEEIIYLIMAYPKNAKDSLTDTEKA 97
Cdd:pfam06296  15 KEGISDEELCEAIEEAEQGLIDADL---GGGVIKKRVARPGGGKSGGYRTIVLYRAGERAFFVYGFAKNDRANISDKELA 91


                  .
gi 446435696   98 Q 98
Cdd:pfam06296  92 A 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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