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Conserved domains on  [gi|446420717|ref|WP_000498572|]
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MULTISPECIES: threonine/serine exporter family protein [Staphylococcus]

Protein Classification

threonine/serine exporter family protein( domain architecture ID 10007602)

threonine/serine exporter family protein similar to ThrE, a membrane protein involved in the export of threonine and serine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-138 5.72e-35

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


:

Pssm-ID: 442828  Cd Length: 150  Bit Score: 118.76  E-value: 5.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717   1 MFWILNFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYTLFFNgFNVHTIYSSFFGSLALGLLSHYMARKQKEPAI 80
Cdd:COG3610    4 LPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLD-LGLGPVLATFVAALVVGLLAELLARRLKAPAT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446420717  81 IFMVTGIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFADQISKL 138
Cdd:COG3610   83 VFTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARP 140
 
Name Accession Description Interval E-value
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-138 5.72e-35

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 118.76  E-value: 5.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717   1 MFWILNFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYTLFFNgFNVHTIYSSFFGSLALGLLSHYMARKQKEPAI 80
Cdd:COG3610    4 LPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLD-LGLGPVLATFVAALVVGLLAELLARRLKAPAT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446420717  81 IFMVTGIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFADQISKL 138
Cdd:COG3610   83 VFTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARP 140
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 6-135 3.52e-34

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 116.08  E-value: 3.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717    6 NFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYtLFFNGFNVHTIYSSFFGSLALGLLSHYMARKQKEPAIIFMVT 85
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVY-LLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVP 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 446420717   86 GIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFADQI 135
Cdd:pfam12821  80 GIIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSLI 129
PRK09917 PRK09917
threonine/serine exporter;
4-129 4.08e-04

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 38.60  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717   4 ILNFIFSFLASMF--------FCVIFDAPRKLYLSCGFVGTCGWMVYTLFFN-GFNVHtiYSSFFGSLALGLLSHYMARK 74
Cdd:PRK09917   3 VIEFLLALAQDMIlaaipavgFAMVFNVPVRALRWCALLGAIGHGSRMLMMTsGLNIE--WSTFMASMLVGTIGIQWSRW 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446420717  75 QKEPAIIFMVTGIIPLVPGGLAYDATKNLVLLN--------FSTAINTMLEVTLIAGAIALGL 129
Cdd:PRK09917  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKIShlgyseplMITLLTNFLKASSIVGALSIGL 143
 
Name Accession Description Interval E-value
YjjB COG3610
Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];
1-138 5.72e-35

Uncharacterized membrane protein YjjB, DUF3815 family [Function unknown];


Pssm-ID: 442828  Cd Length: 150  Bit Score: 118.76  E-value: 5.72e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717   1 MFWILNFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYTLFFNgFNVHTIYSSFFGSLALGLLSHYMARKQKEPAI 80
Cdd:COG3610    4 LPLLLQLLAAFVAAVGFAVLFNAPRRALLWAGLGGALGWLVYLLLLD-LGLGPVLATFVAALVVGLLAELLARRLKAPAT 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446420717  81 IFMVTGIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFADQISKL 138
Cdd:COG3610   83 VFTVPGIIPLVPGSGAYRAMYALVEGDYLAALSNGLEALLIAGALAAGLLLGSLLARP 140
ThrE_2 pfam12821
Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the ...
 6-135 3.52e-34

Threonine/Serine exporter, ThrE; ThrE_2 is a family of membrane proteins involved in the export of threonine and serine. L-threonine, L-serine are both substrates for the exporter. The exporter exhibits nine-ten predicted transmembrane-spanning helices with long charged C and N termini and an amphipathic helix present within the N terminus. L-Threonine can be made by the amino acid-producing bacterium Corynebacterium glutamicum, but the potential for amino acid formation can be considerably improved by reducing its intracellular degradation into glycine and increasing its export by this exporter. Members of the family are found in Bacteria, Archaea, and the fungal kingdoms, and the family can exist either as a single long polypeptide chain or as two short polypeptides. All family members show an extended hydrophilic N-terminal domain with weak sequence similarity to portions of hydrolases (proteases, peptidases, and glycosidases); this suggests that since this region is cytoplasmic to the membrane it may be generating the transport substrate, so may imply that threonine may not be the primary substrate and the ThrE has a subsidiary function.


Pssm-ID: 432807  Cd Length: 129  Bit Score: 116.08  E-value: 3.52e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717    6 NFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYtLFFNGFNVHTIYSSFFGSLALGLLSHYMARKQKEPAIIFMVT 85
Cdd:pfam12821   1 QLIFAFIATLGFGILFNVPKRALFYAGIGGAVGWLVY-LLLMHFGSSIALASFLAALAIGLLSEIFARRLKAPVTVFLVP 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 446420717   86 GIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFADQI 135
Cdd:pfam12821  80 GIIPLVPGGGAYNTMYYLVQGNYALAVSYGLETLFIAGAIALGLVLVSLI 129
PRK09917 PRK09917
threonine/serine exporter;
4-129 4.08e-04

threonine/serine exporter;


Pssm-ID: 182143  Cd Length: 157  Bit Score: 38.60  E-value: 4.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717   4 ILNFIFSFLASMF--------FCVIFDAPRKLYLSCGFVGTCGWMVYTLFFN-GFNVHtiYSSFFGSLALGLLSHYMARK 74
Cdd:PRK09917   3 VIEFLLALAQDMIlaaipavgFAMVFNVPVRALRWCALLGAIGHGSRMLMMTsGLNIE--WSTFMASMLVGTIGIQWSRW 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446420717  75 QKEPAIIFMVTGIIPLVPGGLAYDATKNLVLLN--------FSTAINTMLEVTLIAGAIALGL 129
Cdd:PRK09917  81 YLAHPKVFTVAAVIPMFPGISAYTAMISAVKIShlgyseplMITLLTNFLKASSIVGALSIGL 143
ThrE pfam06738
Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that ...
 3-132 6.09e-04

Putative threonine/serine exporter; ThrE is a family of bacterial and Archaeal proteins that catalyze the export of L-threonine from the cell. UniProtKB:Q79VD1 has been characterized as being necessary for this export. The domain exhibits 10 putative TMs and catalyzes the proton-motive-force-dependent efflux of threonine and serine.


Pssm-ID: 461997  Cd Length: 241  Bit Score: 38.27  E-value: 6.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717    3 WILNFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYtLFFNGFNVHTIYSSFFGSLALGLLSHYMARKQ--KEPAI 80
Cdd:pfam06738 108 RWLVVLAAGLASAAFALLFGGDWIDFLVAFLAGGLGGLLR-LVLNRRGLNSFFFEAVAAFVASLLALLAVSLGlgINPDA 186

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446420717   81 IfMVTGIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFA 132
Cdd:pfam06738 187 I-IIGSIMLLVPGLPLTNAVRDLIAGDLVSGLARLVEAILIALAIAFGIALA 237
YjjP COG2966
Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];
3-132 2.33e-03

Uncharacterized membrane protein YjjP, DUF1212 family [Function unknown];


Pssm-ID: 442206 [Multi-domain]  Cd Length: 409  Bit Score: 36.84  E-value: 2.33e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446420717   3 WILNFIFSFLASMFFCVIFDAPRKLYLSCGFVGTCGWMVYtLFFNGFNVHTIYSSFFGSLALGLLSHYMARKQ--KEPAI 80
Cdd:COG2966  120 RWLVVLAAGLAAAAFALLFGGGWLDFLVAFLAGALGGLLR-RLLARRGLNPFFVEALAAFVATLIALLLARLGlgLNPDL 198

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446420717  81 IfMVTGIIPLVPGGLAYDATKNLVLLNFSTAINTMLEVTLIAGAIALGLLFA 132
Cdd:COG2966  199 I-IIGSILPLVPGVPLTNAVRDLIAGDLVSGLARLAEALLIALAIAFGVALA 249
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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