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Conserved domains on  [gi|446415957|ref|WP_000493812|]
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MULTISPECIES: DUF4376 domain-containing protein [Salmonella]

Protein Classification

Caudo_TAP and DUF4376 domain-containing protein( domain architecture ID 10348800)

Caudo_TAP and DUF4376 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4376 pfam14301
Domain of unknown function (DUF4376); This domain family is found in bacteria and viruses, and ...
 124-224 2.39e-27

Domain of unknown function (DUF4376); This domain family is found in bacteria and viruses, and is approximately 110 amino acids in length.


:

Pssm-ID: 433852  Cd Length: 102  Bit Score: 100.50  E-value: 2.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446415957  124 QQIKAHRDDVTADYIVIDGNHFHSDANSRIQQMSLTRMGQAKQIPAGLMWQTKNNGLIELTNDIAAQFETVTMDHDMHLF 203
Cdd:pfam14301   2 AEIKAWRDEKEAGGIEVNGKRIDTDPESRLRLMGVLLAAKLPGEQGTPAWTLADNSTVTLTAEQLIALGQAVTQHVQACF 81

                          90       100
                  ....*....|....*....|.
gi 446415957  204 ANAQRHIAAVEALGDIQEVLD 224
Cdd:pfam14301  82 DRAREHKAAIEAAETLEAVEA 102
Caudo_TAP super family cl17077
Caudovirales tail fibre assembly protein, lambda gpK; This family contains bacterial and phage ...
 69-131 3.58e-05

Caudovirales tail fibre assembly protein, lambda gpK; This family contains bacterial and phage tail fibre assembly proteins. E.coli contains several members of this family although the function of these proteins is uncertain. Using the lambda phage members as examples, there are both gptfa and gpK tail proteins here. GpK forms part of the TTC or tail-tip complex that is located at the distal end of the tail. TTCs form the platform on which the tail-tube proteins self-assemble and are also the attachment point for fibres or receptor-binding proteins that mediate phage-adsorption to the surface of the host cell. TTC assembly starts with gpJ, which is also known as the central tail fibre and is involved in host-cell adsorption. It is the C-terminus of gpJ that interacts with the lamB receptor on host cells. A number of intermediates including gpK then interact with gpJ during tail morphogenesis.


The actual alignment was detected with superfamily member pfam02413:

Pssm-ID: 450149  Cd Length: 130  Bit Score: 42.02  E-value: 3.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446415957   69 RGQIVYDKESGHQVNITELGGLFENVTIIS---------PMSKFDRWNGETWQPSITDAKAAKIQQIKAHRD 131
Cdd:pfam02413   1 RGQKLFSTDTLKPQYIAEGGILPESVTEVSdipenrripPPGKFDYWDGEGVPAWVTATKEEQIQQAEQEKQ 72
 
Name Accession Description Interval E-value
DUF4376 pfam14301
Domain of unknown function (DUF4376); This domain family is found in bacteria and viruses, and ...
 124-224 2.39e-27

Domain of unknown function (DUF4376); This domain family is found in bacteria and viruses, and is approximately 110 amino acids in length.


Pssm-ID: 433852  Cd Length: 102  Bit Score: 100.50  E-value: 2.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446415957  124 QQIKAHRDDVTADYIVIDGNHFHSDANSRIQQMSLTRMGQAKQIPAGLMWQTKNNGLIELTNDIAAQFETVTMDHDMHLF 203
Cdd:pfam14301   2 AEIKAWRDEKEAGGIEVNGKRIDTDPESRLRLMGVLLAAKLPGEQGTPAWTLADNSTVTLTAEQLIALGQAVTQHVQACF 81

                          90       100
                  ....*....|....*....|.
gi 446415957  204 ANAQRHIAAVEALGDIQEVLD 224
Cdd:pfam14301  82 DRAREHKAAIEAAETLEAVEA 102
Caudo_TAP pfam02413
Caudovirales tail fibre assembly protein, lambda gpK; This family contains bacterial and phage ...
 69-131 3.58e-05

Caudovirales tail fibre assembly protein, lambda gpK; This family contains bacterial and phage tail fibre assembly proteins. E.coli contains several members of this family although the function of these proteins is uncertain. Using the lambda phage members as examples, there are both gptfa and gpK tail proteins here. GpK forms part of the TTC or tail-tip complex that is located at the distal end of the tail. TTCs form the platform on which the tail-tube proteins self-assemble and are also the attachment point for fibres or receptor-binding proteins that mediate phage-adsorption to the surface of the host cell. TTC assembly starts with gpJ, which is also known as the central tail fibre and is involved in host-cell adsorption. It is the C-terminus of gpJ that interacts with the lamB receptor on host cells. A number of intermediates including gpK then interact with gpJ during tail morphogenesis.


Pssm-ID: 426761  Cd Length: 130  Bit Score: 42.02  E-value: 3.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446415957   69 RGQIVYDKESGHQVNITELGGLFENVTIIS---------PMSKFDRWNGETWQPSITDAKAAKIQQIKAHRD 131
Cdd:pfam02413   1 RGQKLFSTDTLKPQYIAEGGILPESVTEVSdipenrripPPGKFDYWDGEGVPAWVTATKEEQIQQAEQEKQ 72
 
Name Accession Description Interval E-value
DUF4376 pfam14301
Domain of unknown function (DUF4376); This domain family is found in bacteria and viruses, and ...
 124-224 2.39e-27

Domain of unknown function (DUF4376); This domain family is found in bacteria and viruses, and is approximately 110 amino acids in length.


Pssm-ID: 433852  Cd Length: 102  Bit Score: 100.50  E-value: 2.39e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446415957  124 QQIKAHRDDVTADYIVIDGNHFHSDANSRIQQMSLTRMGQAKQIPAGLMWQTKNNGLIELTNDIAAQFETVTMDHDMHLF 203
Cdd:pfam14301   2 AEIKAWRDEKEAGGIEVNGKRIDTDPESRLRLMGVLLAAKLPGEQGTPAWTLADNSTVTLTAEQLIALGQAVTQHVQACF 81

                          90       100
                  ....*....|....*....|.
gi 446415957  204 ANAQRHIAAVEALGDIQEVLD 224
Cdd:pfam14301  82 DRAREHKAAIEAAETLEAVEA 102
Caudo_TAP pfam02413
Caudovirales tail fibre assembly protein, lambda gpK; This family contains bacterial and phage ...
 69-131 3.58e-05

Caudovirales tail fibre assembly protein, lambda gpK; This family contains bacterial and phage tail fibre assembly proteins. E.coli contains several members of this family although the function of these proteins is uncertain. Using the lambda phage members as examples, there are both gptfa and gpK tail proteins here. GpK forms part of the TTC or tail-tip complex that is located at the distal end of the tail. TTCs form the platform on which the tail-tube proteins self-assemble and are also the attachment point for fibres or receptor-binding proteins that mediate phage-adsorption to the surface of the host cell. TTC assembly starts with gpJ, which is also known as the central tail fibre and is involved in host-cell adsorption. It is the C-terminus of gpJ that interacts with the lamB receptor on host cells. A number of intermediates including gpK then interact with gpJ during tail morphogenesis.


Pssm-ID: 426761  Cd Length: 130  Bit Score: 42.02  E-value: 3.58e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446415957   69 RGQIVYDKESGHQVNITELGGLFENVTIIS---------PMSKFDRWNGETWQPSITDAKAAKIQQIKAHRD 131
Cdd:pfam02413   1 RGQKLFSTDTLKPQYIAEGGILPESVTEVSdipenrripPPGKFDYWDGEGVPAWVTATKEEQIQQAEQEKQ 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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