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Conserved domains on  [gi|446415223|ref|WP_000493078|]
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helix-turn-helix domain-containing protein [Streptococcus pneumoniae]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 11443570)

helix-turn-helix domain-containing protein such as an XRE (Xenobiotic Response Element) family transcriptional regulator

Gene Ontology:  GO:0003677
PubMed:  37972151

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-68 1.57e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


:

Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.07  E-value: 1.57e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446415223   6 EIVKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYLLGRTDNPA 68
Cdd:COG1396   10 ERLRELRKARGLTQEELAERLGVSRSTISRIERGRrnPSLETLLKLAKALGVSLDELLGGADEEL 74
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-68 1.57e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.07  E-value: 1.57e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446415223   6 EIVKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYLLGRTDNPA 68
Cdd:COG1396   10 ERLRELRKARGLTQEELAERLGVSRSTISRIERGRrnPSLETLLKLAKALGVSLDELLGGADEEL 74
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-60 1.27e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 45.24  E-value: 1.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446415223   6 EIVKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYL 60
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKrnPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-60 4.02e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 40.96  E-value: 4.02e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446415223     8 VKDLCEKQGISLNTLEDKLKLGKNSLYGL--KRNQPSAERLQQIADYFNVSTDYL 60
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIenGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 8-60 5.68e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 40.60  E-value: 5.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446415223    8 VKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYL 60
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKrePSLETLKKLAEALGVSLDEL 55
 
Name Accession Description Interval E-value
HipB COG1396
Transcriptional regulator, contains XRE-family HTH domain [Transcription];
6-68 1.57e-08

Transcriptional regulator, contains XRE-family HTH domain [Transcription];


Pssm-ID: 441006 [Multi-domain]  Cd Length: 83  Bit Score: 48.07  E-value: 1.57e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446415223   6 EIVKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYLLGRTDNPA 68
Cdd:COG1396   10 ERLRELRKARGLTQEELAERLGVSRSTISRIERGRrnPSLETLLKLAKALGVSLDELLGGADEEL 74
HTH_XRE cd00093
Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the ...
 6-60 1.27e-07

Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators.


Pssm-ID: 238045 [Multi-domain]  Cd Length: 58  Bit Score: 45.24  E-value: 1.27e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446415223   6 EIVKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYL 60
Cdd:cd00093    2 ERLKELRKEKGLTQEELAEKLGVSRSTISRIENGKrnPSLETLEKLAKALGVSLDEL 58
HTH_XRE smart00530
Helix-turn-helix XRE-family like proteins;
8-60 4.02e-06

Helix-turn-helix XRE-family like proteins;


Pssm-ID: 197775 [Multi-domain]  Cd Length: 56  Bit Score: 40.96  E-value: 4.02e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 446415223     8 VKDLCEKQGISLNTLEDKLKLGKNSLYGL--KRNQPSAERLQQIADYFNVSTDYL 60
Cdd:smart00530   2 LKELREEKGLTQEELAEKLGVSRSTLSRIenGKRKPSLETLKKLAKALGVSLDEL 56
HTH_3 pfam01381
Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and ...
 8-60 5.68e-06

Helix-turn-helix; This large family of DNA binding helix-turn helix proteins includes Cro and CI. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteriztic of the whole family.


Pssm-ID: 460181 [Multi-domain]  Cd Length: 55  Bit Score: 40.60  E-value: 5.68e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446415223    8 VKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYL 60
Cdd:pfam01381   1 LKELREELGLSQEELAEKLGVSRSTISKIENGKrePSLETLKKLAEALGVSLDEL 55
HTH_19 pfam12844
Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. ...
 6-65 1.38e-05

Helix-turn-helix domain; Members of this family contains a DNA-binding helix-turn-helix domain. This family contains many example antitoxins from bacterial toxin-antitoxin systems. These antitoxins are likely to be DNA-binding domains.


Pssm-ID: 463728 [Multi-domain]  Cd Length: 64  Bit Score: 39.96  E-value: 1.38e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446415223    6 EIVKDLCEKQGISLNTLEDKLKLGKNSLYGLKRNQ--PSAERLQQIADYFNVSTDYLLGRTD 65
Cdd:pfam12844   2 ERLRKAREERGLTQEELAERLGISRSQLSAIENGKsvPPAETLYKIAELLGVPANWLLQGEG 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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