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Conserved domains on  [gi|446414428|ref|WP_000492283|]
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MULTISPECIES: tetracycline efflux MFS transporter Tet(K) [Bacteria]

Protein Classification

MFS transporter( domain architecture ID 13022956)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0055085|GO:0022857|GO:0016020
PubMed:  26758938|26098515|26234418
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-451 1.48e-41

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 151.56  E-value: 1.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWsyllilpmit 178
Cdd:cd17321   81 APS-LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGW---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 ivtipflikvmvpgkstkntldivgivlmsisiicfmlfttnyNWTFLILFTIFFVIFIkhisrvsnpfinpkLGKNipF 258
Cdd:cd17321  150 -------------------------------------------RWIFLINVPIGLVALL--------------LART--F 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIfPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFL 338
Cdd:cd17321  171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL-PLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 339 TIAFFVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLSLQLINRKL 417
Cdd:cd17321  250 LLALLGADSSVWLLLPGLVLLGlGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 446414428 418 VLEFINYSSGV-------YSNILVAMAILIILCCLLTIIVF 451
Cdd:cd17321  330 DSGVAALLSAAaaafaagFHLAFLVAAALALLAALLALLLP 370
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-451 1.48e-41

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 151.56  E-value: 1.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWsyllilpmit 178
Cdd:cd17321   81 APS-LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGW---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 ivtipflikvmvpgkstkntldivgivlmsisiicfmlfttnyNWTFLILFTIFFVIFIkhisrvsnpfinpkLGKNipF 258
Cdd:cd17321  150 -------------------------------------------RWIFLINVPIGLVALL--------------LART--F 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIfPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFL 338
Cdd:cd17321  171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL-PLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 339 TIAFFVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLSLQLINRKL 417
Cdd:cd17321  250 LLALLGADSSVWLLLPGLVLLGlGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 446414428 418 VLEFINYSSGV-------YSNILVAMAILIILCCLLTIIVF 451
Cdd:cd17321  330 DSGVAALLSAAaaafaagFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-395 1.64e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.85  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  15 VLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSL 94
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 IAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLIL 174
Cdd:COG2814   91 LCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 175 PMITIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSIsiicfmlfttnynwtflilftiffvifikhisrvsnpfinpklgK 254
Cdd:COG2814  170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELL--------------------------------------------R 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 255 NIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGnSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSIS 334
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG-LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446414428 335 ISFLTIAFFveFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFL 395
Cdd:COG2814  285 LGLLLLALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 14-409 2.25e-27

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 114.01  E-value: 2.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   14 SVLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGS 93
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   94 LIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWS---Y 170
Cdd:TIGR00711  82 LLCGVAPN-LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRwifL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  171 LLILPMITIVTIPFLI-KVMVPGKSTKntLDIVGIVLMSISIICFML----------FTTNYNWTFLILFTIFFVIFIKH 239
Cdd:TIGR00711 161 INVPIGIIVVVVAFFIlPRDKPAASEN--FDFLGLLLLSVGLGSLLYglsegpergwFDSNEILILSITGLVAIIAFVVW 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  240 ISRVSNPFINPKLGKNIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGnSVIFPGTMSVIVFGYFGGFLVDR 319
Cdd:TIGR00711 239 ELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAG-LHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  320 KGSLFVFILGSLSISISFLTIAFFVEFSMWLTTFMFI-FVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSE 397
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPqFIRGfGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGG 397

                         410
                  ....*....|..
gi 446414428  398 GTGIAIVGGLLS 409
Cdd:TIGR00711 398 SIGTALITTILT 409
MFS_1 pfam07690
Major Facilitator Superfamily;
19-396 2.29e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.85  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   19 LCILSFFSVLNEMVLNVSLP-DIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAF 97
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   98 IGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLILPMI 177
Cdd:pfam07690  81 FASS-LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  178 TIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSISIIcFMLFTTNYNWTFLILFTIFFVIFIkhisrvsnpfinpklgknIP 257
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW-KALLRDPVLWLLLALLLFGFAFFG------------------LL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  258 FMLGLFSGGLIFSIVAGFIsmvpymmktiyhvnvatignsVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISF 337
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGL---------------------LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  338 LTIAFFVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLS 396
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGfGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
emrD PRK11652
multidrug transporter EmrD;
36-182 3.97e-10

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 61.46  E-value: 3.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  36 SLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGV 115
Cdd:PRK11652  30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHS-LTVLIAASAIQGL 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446414428 116 GSAAfpsliMVVVARNITR-----KKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHW--SYLLILPMITIVTI 182
Cdd:PRK11652 109 GTGV-----GGVMARTLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWraCYLFLLLLGAGVTF 177
 
Name Accession Description Interval E-value
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 19-451 1.48e-41

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 151.56  E-value: 1.48e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWsyllilpmit 178
Cdd:cd17321   81 APS-LAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGW---------- 149

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 ivtipflikvmvpgkstkntldivgivlmsisiicfmlfttnyNWTFLILFTIFFVIFIkhisrvsnpfinpkLGKNipF 258
Cdd:cd17321  150 -------------------------------------------RWIFLINVPIGLVALL--------------LART--F 170

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIfPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFL 338
Cdd:cd17321  171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALL-PLALAMLVAAPLAGRLADRFGPRLVLVAGLLLTAVGLL 249

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 339 TIAFFVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLSLQLINRKL 417
Cdd:cd17321  250 LLALLGADSSVWLLLPGLVLLGlGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLTAGLSANLG 329

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|.
gi 446414428 418 VLEFINYSSGV-------YSNILVAMAILIILCCLLTIIVF 451
Cdd:cd17321  330 DSGVAALLSAAaaafaagFHLAFLVAAALALLAALLALLLP 370
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-395 1.64e-30

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 120.85  E-value: 1.64e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  15 VLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSL 94
Cdd:COG2814   11 ALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 IAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLIL 174
Cdd:COG2814   91 LCALAPS-LWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLV 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 175 PMITIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSIsiicfmlfttnynwtflilftiffvifikhisrvsnpfinpklgK 254
Cdd:COG2814  170 NAVLALLALLLLLRLLPESRPAARARLRGSLRELL--------------------------------------------R 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 255 NIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGnSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSIS 334
Cdd:COG2814  206 RPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAG-LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLA 284

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446414428 335 ISFLTIAFFveFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFL 395
Cdd:COG2814  285 LGLLLLALA--GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFL 343
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 14-409 2.25e-27

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 114.01  E-value: 2.25e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   14 SVLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGS 93
Cdd:TIGR00711   2 LLTIVLMLGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   94 LIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWS---Y 170
Cdd:TIGR00711  82 LLCGVAPN-LELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRwifL 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  171 LLILPMITIVTIPFLI-KVMVPGKSTKntLDIVGIVLMSISIICFML----------FTTNYNWTFLILFTIFFVIFIKH 239
Cdd:TIGR00711 161 INVPIGIIVVVVAFFIlPRDKPAASEN--FDFLGLLLLSVGLGSLLYglsegpergwFDSNEILILSITGLVAIIAFVVW 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  240 ISRVSNPFINPKLGKNIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGnSVIFPGTMSVIVFGYFGGFLVDR 319
Cdd:TIGR00711 239 ELTDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAG-LHILPVGLAPMLSSPIAGRMGDK 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  320 KGSLFVFILGSLSISISFLTIAFFVEFSMWLTTFMFI-FVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSE 397
Cdd:TIGR00711 318 IDPRKLVTIGLILYAVGFYWRAFTFTPDTPFLAIALPqFIRGfGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGG 397

                         410
                  ....*....|..
gi 446414428  398 GTGIAIVGGLLS 409
Cdd:TIGR00711 398 SIGTALITTILT 409
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 19-451 4.41e-27

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 111.90  E-value: 4.41e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17503    1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLlilpmit 178
Cdd:cd17503   81 APN-LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWI------- 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 ivtipFLIKVMvpgkstkntldivgivlmsISIICFMLfttnynwtflilftiffvifikhisrvsNPFINPKLGKNIPF 258
Cdd:cd17503  153 -----FYINLP-------------------IGILALLL----------------------------APLLDLRLFKDRNF 180

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGnSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFL 338
Cdd:cd17503  181 TLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESG-LVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALGTL 259

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 339 TIAFF-VEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLSLQLINRKL 417
Cdd:cd17503  260 LLAFLtPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFHHS 339

                        410       420       430
                 ....*....|....*....|....*....|....
gi 446414428 418 VLEFINYSSGVYSNILVAMAILIILCCLLTIIVF 451
Cdd:cd17503  340 RLSELLAQQVQKQALIIAFNDAFLVSAILLLVGL 373
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 28-442 1.37e-22

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 98.80  E-value: 1.37e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  28 LNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILI 107
Cdd:cd17504   10 LVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPN-LPVLI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 108 FGRLVQGVGSAAFPsLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLILPmiTIVTIPFLIk 187
Cdd:cd17504   89 AGRALQGIGGAVFP-LAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTA--APVAVLLAA- 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 188 vMVPgkstkntldIVGIVLMSISIICFMLFTtnynwTFLILFTIFFVIFIkhisrvsnpfinpklgknIPFMLGL-FSGG 266
Cdd:cd17504  165 -LVP---------LIDLRLLRRRNVLLANIT-----ALLAGFGMFMVFQL------------------LPQLLQLpTPTG 211

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 267 LIFSIVAGFISMVPYmmktiyhvnvatignsvifpgTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFLTIAFFVeF 346
Cdd:cd17504  212 FGLGITEAGLLLLPG---------------------ALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLH-S 269

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 347 SMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEE--VASGMSLLNFTSFLSEGTgiAIVGGLLSLQLINrklVLEFINY 424
Cdd:cd17504  270 SLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRtgIATGMNTVLRTIGSAIGP--AIAGAILTTYTVS---ITSGGVP 344

                        410
                 ....*....|....*...
gi 446414428 425 SSGVYSNILVAMAILIIL 442
Cdd:cd17504  345 TEGAYVLAFLIGAALALA 362
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 16-405 2.86e-20

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 92.25  E-value: 2.86e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:cd17320    1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  96 AFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLilp 175
Cdd:cd17320   81 CALASS-IEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIF--- 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 176 mitivtipflikvmvpgkstkntldivgIVLMSISIICFMLFTTNYNWTFLILFTIFFVIFIKHISRvsnpfinpKLGKN 255
Cdd:cd17320  157 ----------------------------VFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYK--------RVLKN 200

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 256 IPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIFPGtMSVIVFGYFGGFLVDRKGSLFVFILGSLSI-- 333
Cdd:cd17320  201 RRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNA-IALILGSLLNGRLVRRFGPRRLLRLGLLLLla 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446414428 334 -SISFLTIAFFVEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLsEEEVASGMSLLNFTSFLSEGTGIAIVG 405
Cdd:cd17320  280 aALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPF-PHVAGTASALLGFLQFLIGALAGALVG 351
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 16-408 7.83e-20

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 90.69  E-value: 7.83e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:cd17324    1 LLALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  96 AFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSY-LLIL 174
Cdd:cd17324   81 AALAPS-FALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAaFLAI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 175 PMITIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSIsiicfmLFTTNYNWTFLILFTIFFVIFIkhisrvSNPFINPKLgK 254
Cdd:cd17324  160 AVLALLAALLLWRLLPSLPPKKPGSLGLLSSLLLL------LRNPRLRLAYLITFLLFGGFFA------LYTYLAPFL-T 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 255 NIPFMLGLFSGGLIFSI-VAGFISMvpymmktiyhvnvatignsvifpgtmsvivfgYFGGFLVDRKGSLFVFILGSLsi 333
Cdd:cd17324  227 DVPGFSSSAIIGLLLLFgVAGVVGS--------------------------------PLAGRLADRGGRRALLIALLL-- 272

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446414428 334 sISFLTIAFFVEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGiAIVGGLL 408
Cdd:cd17324  273 -LAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALG-AALGGLV 345
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 19-409 3.19e-18

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 86.09  E-value: 3.19e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17474    4 VFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAhYIHWSYLLILPMIT 178
Cdd:cd17474   84 SDS-FALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 IVTIPFLIKVMVPGKSTKNTLDIVGIVLMsisiicfMLFTTNYNWTFLILFTIFFvifikhisrvsnpfinpklgknipF 258
Cdd:cd17474  162 IPVAFLAILFLLPEPKEKAKSSSATKLRD-------LKKALRGRGLLTFLVSAFL------------------------Y 210

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFsgglifsivaGFISMVPYMMKTIYHVNVATIGNSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFL 338
Cdd:cd17474  211 FFLYF----------AFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLL 280

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446414428 339 TIAFFveFSMWLtTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd17474  281 LLGFV--PSLAL-LLIAIVLFGlGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLE 349
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
6-456 1.96e-17

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 83.38  E-value: 1.96e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   6 KKFKGLFYSVLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIG 85
Cdd:COG2271    2 RAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  86 ISLSCLGSLIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHY 165
Cdd:COG2271   82 LLLWGLATLLFGFATS-FWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 166 IHWSYLLIlpmitIVTIPFLIkvmvpgkstkntldivgIVLMSISIICFMLFTTNYNWTFLILFTIFFVIFIKHISRVSn 245
Cdd:COG2271  161 FGWRAAFL-----ILGLPGLL-----------------LALLRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQ- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 246 pfinpklgknipfmlglfsgglifsivAGFISMVPYMMktiyhvnvatignsvifpgtmsVIVFGYFGGFLVDRKGSLFV 325
Cdd:COG2271  218 ---------------------------AGLLLSLPFLA----------------------GIVGSLLGGWLSDRLGRRRK 248

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 326 FILGSLSISISFLTIAFFVEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVG 405
Cdd:COG2271  249 LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVG 328

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446414428 406 GLLSLqlinrklvlefinyssGVYSNILVAMAILIILCCLLTIIVFKRSEK 456
Cdd:COG2271  329 YLLDA----------------TGYQAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
19-396 2.29e-17

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 82.85  E-value: 2.29e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   19 LCILSFFSVLNEMVLNVSLP-DIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAF 97
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   98 IGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLILPMI 177
Cdd:pfam07690  81 FASS-LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  178 TIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSISIIcFMLFTTNYNWTFLILFTIFFVIFIkhisrvsnpfinpklgknIP 257
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAW-KALLRDPVLWLLLALLLFGFAFFG------------------LL 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  258 FMLGLFSGGLIFSIVAGFIsmvpymmktiyhvnvatignsVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISF 337
Cdd:pfam07690 221 TYLPLYQEVLGLSALLAGL---------------------LLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAA 279

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  338 LTIAFFVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLS 396
Cdd:pfam07690 280 LGLLLLSLTLSSLWLLLALLLLGfGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLG 339
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 19-408 2.46e-17

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 83.39  E-value: 2.46e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17325    1 LSLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLILPMI- 177
Cdd:cd17325   81 ATS-YWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAAl 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 178 TIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSIsiicfmLFTTNYNWTFLILFTIFFVIFIkhisrvsnpfinpklgknip 257
Cdd:cd17325  160 ALLALVLALLLLPEPRPPPNKRAVSAARLRSG------LRLLLRDRRLLALFLAIFVLAF-------------------- 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 258 fmlglfsgglifsIVAGFISMVPYMMKTIYHVNVATIGNSVIFPGTMSVIVFGYFGGfLVDRKGSLFVFILGSLSISISF 337
Cdd:cd17325  214 -------------AFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGK-LSDRIGRKPLILIGLLLSAVAL 279

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446414428 338 LTIAFFVEFSMWLTTFMFIFVMGGLSFtkTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGiAIVGGLL 408
Cdd:cd17325  280 LLLPLATSFWLLLLLLALLGLGLGLVF--PATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG-PLLGGFL 347
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 19-168 1.42e-16

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 80.69  E-value: 1.42e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITnWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17502    1 LMLALFLAALDQTIVATALPTIVAEFGGLSLVS-WVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGL 79

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHW 168
Cdd:cd17502   80 APN-MTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSW 148
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 13-174 4.46e-16

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 78.31  E-value: 4.46e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  13 YSVLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLG 92
Cdd:COG0477   13 RRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLA 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  93 SLIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLL 172
Cdd:COG0477   93 SLLCGLAPS-PELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIF 171


                 ..
gi 446414428 173 IL 174
Cdd:COG0477  172 LI 173
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
13-457 1.26e-15

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 78.38  E-value: 1.26e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  13 YSVLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLG 92
Cdd:COG2223    4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  93 SLIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWS--Y 170
Cdd:COG2223   84 LLLLALAVS-YWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRnaF 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 171 LLILPMITIVTIPFLIKVMVPGKSTKNTLDIVGIVLMSIsiicfmlFTTNYNWTFLILFTIFFVIFIkhisrvsnpfinp 250
Cdd:COG2223  163 LILGILLLVVAVLAWLFLRDPPAGAAAAAKASLRDQLEA-------LRDPRFWLLSLLYFGTFGSFI------------- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 251 klgknipfmlglfsgglifsivaGFISMVPYMMKTIYHVNVATIGNSVIFPGTMSvIVFGYFGGFLVDRKGSLFVFILGS 330
Cdd:COG2223  223 -----------------------GFSSWLPPYLVDQFGLSAATAGLLAALFALLG-ALGRPLGGWLSDRIGGRRVLLIVF 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 331 LSISISFLTIAFFVEfSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLSL 410
Cdd:COG2223  279 ALMALGLLLLALALG-SLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDA 357

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 446414428 411 qlinrklvlefinysSGVYSNILVAMAILIILCCLLTIIVFKRSEKQ 457
Cdd:COG2223  358 ---------------TGSYTAAFLVFAVLALVALVLTLLLYRRPRRA 389
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 16-360 9.47e-15

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 75.50  E-value: 9.47e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:TIGR00710   7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   96 AFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLIlp 175
Cdd:TIGR00710  87 LALSNN-IETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFA-- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  176 mitivtipflikvmvpgkstknTLDIVGIVLmsISIICFMLFTTNYNWTFLILFTIF--FVIFIKHISrvsnpfinpklg 253
Cdd:TIGR00710 164 ----------------------FLSLAGILL--SALIFFILPETLPYEARIQISTYFetFLLLLKSKM------------ 207

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  254 knipFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSvIFPGTMSVIVFGYFGGFLVDRKG--SLFVFILGSL 331
Cdd:TIGR00710 208 ----FWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGLL-FALNIIAMIFGGFLNGRFIKKWGakSLLRMGLILF 282

                         330       340
                  ....*....|....*....|....*....
gi 446414428  332 SISISFLTIAFFVEFSMWLTTFMFIFVMG 360
Cdd:TIGR00710 283 AVSAVLLEITAILGLGSWAMIIGPMMFVG 311
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 19-409 1.56e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 62.44  E-value: 1.56e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLILPMIT 178
Cdd:cd06174   81 APS-FWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 IVTIPFLIKVMVPGKSTKNTLDIVGIVLMSISIICFMLfttnynwtflilftiffvifikhisrvsnpfinpKLGKNIPF 258
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK----------------------------------RVLKNPGL 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIFPGTMSvIVFGYFGGFLVDRKGSLFVFILGSLsISISFL 338
Cdd:cd06174  206 WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAG-ALGSLLLGLLSDRLIGRKPLLLIGL-LLMALG 283

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446414428 339 TIAFFVEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd06174  284 LALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLA 354
emrD PRK11652
multidrug transporter EmrD;
36-182 3.97e-10

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 61.46  E-value: 3.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  36 SLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGV 115
Cdd:PRK11652  30 AIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHS-LTVLIAASAIQGL 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446414428 116 GSAAfpsliMVVVARNITR-----KKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHW--SYLLILPMITIVTI 182
Cdd:PRK11652 109 GTGV-----GGVMARTLPRdlyegTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWraCYLFLLLLGAGVTF 177
PRK10504 PRK10504
putative transporter; Provisional
 18-410 7.83e-10

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 60.90  E-value: 7.83e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  18 WLCILSFF-SVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIA 96
Cdd:PRK10504  13 WIVAFGFFmQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  97 FIGhNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYI--HWSYLLIL 174
Cdd:PRK10504  93 ALS-GTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYAswHWIFLINI 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 175 PMITIVTIPFLiKVMVPGKSTKNTLDIVGIVLMSISIICFMLFTTNYNWTFLILFTIFFVI---------FIKHISRVSN 245
Cdd:PRK10504 172 PVGIIGAIATL-MLMPNYTMQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVavgvvalllYLLHARNNNR 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 246 PFINPKLGKNIPFMLGLFsGGLIFSIVAGfisMVPYMMKTIYHVNvatIGNSVIFPGTMSV-IVFGYFGG-----FLVDR 319
Cdd:PRK10504 251 ALFSLKLFRTRTFSLGLA-GSFAGRIGSG---MLPFMTPVFLQIG---LGFSPFHAGLMMIpMVLGSMGMkrivvQVVNR 323

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 320 KGSLFVFILGSLSISISFLTIAFFVEFSMWLTTFMFIFVMGGLSFTK-TVISKIVSSSLSEEEVASGMSLLNFTSFLSEG 398
Cdd:PRK10504 324 FGYRRVLVATTLGLALVSLLFMLVALLGWYYLLPFVLFLQGMVNSTRfSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMS 403

                        410
                 ....*....|..
gi 446414428 399 TGIAIVGGLLSL 410
Cdd:PRK10504 404 IGVTIAGLLLGL 415
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 19-395 2.36e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 58.74  E-value: 2.36e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHF-NTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAF 97
Cdd:cd17473    4 LLLASTLTVMAGAAIAPALPAIAQHFvPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGL 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  98 IGHNHFFILIFgRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIA----HYIHWSYLLI 173
Cdd:cd17473   84 FLDSLYALLAS-RALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAeigwRAPFLVYLLA 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 174 LPMItIVTIPFLIKVMVPGKSTKNTLD--IVGIVLMSISIICFMLFttnynwtflILFTIFFVIFIKhisrvsnpfinpk 251
Cdd:cd17473  163 LPVL-ILVLLFLPEPARKSKSAASPGAatAAALPWKRVLPIYFLAF---------LAMLLFYVIPIQ------------- 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 252 lgknipfmlglfsgglifsivagfismVPYMMKTIYHVNVATIGNSVIFPGTMSVIVfGYFGGFLVDRKGSLFVFILGSL 331
Cdd:cd17473  220 ---------------------------LPFLLQERGGGSAALIGLALAIASLAGAIG-ALLFGRLKRRLGKRRLLAIGFA 271

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446414428 332 SISISFLTIAFFVefSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFL 395
Cdd:cd17473  272 LMALGFLLLALAS--GLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFL 333
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 57-442 3.07e-09

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 58.38  E-value: 3.07e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  57 AYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGVGsaAFPSLIMVVVARNITRKK 136
Cdd:cd17472   40 IYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATS-IYGLILGRALQGSG--AISSVVMALLADLTREEN 116

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 137 QGKAFGFIGSIVALGEGLGPSIGGIIAHY--IHWSYLLILPMITIVTIPFLIKVmvpgkstKNTLDIVGIVLMSISIICF 214
Cdd:cd17472  117 RTKAMALIGASIGIAFAISMVLGPLLAAHlgVSGLFLITAILSLVSLLILLFFV-------PDPPKIVQISEKEKKKLKK 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 215 MLFTTNynwtfliLFTIFFVIFIKHISRVSNPFINPKLGKNIPFMLGLFSGGLIFSIVAGFISMVPYMmktiyhvnvati 294
Cdd:cd17472  190 LLKNKR-------LLRLDFSIFILHFVLMAFFYILPLLLTQLGGGKGQLWKVYLPAILIGFILMVPFV------------ 250

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 295 gnsvifpgtmsvivfgyfggFLVDRKGSLF-VFILGSLSISISFLTIAFFVEfSMWLTTFMFIFVMGGLSFTKTVISKIV 373
Cdd:cd17472  251 --------------------IYAEKKGKMKqVFVSSILLIAVGFLLLLFAAT-SLWLLIIGLIIFFIGFNLLEALLPSLV 309

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446414428 374 SSSLSEEEVASGMSLLNFTSFLSEGTGiAIVGGLLslqlinrklvLEFINYSSGVYSNILVAMAILIIL 442
Cdd:cd17472  310 SKIAPKEYRGTAMGIYNTSQFLGSFLG-GALGGLL----------WGLLGYSSVFLTILILALLWLLVS 367
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 19-191 8.92e-09

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 57.25  E-value: 8.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEM---VLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISL-SCLGSL 94
Cdd:cd17328    1 VAVLFLINLLNYMdrfTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIwSAATLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 IAFIghNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYI---HWSyL 171
Cdd:cd17328   81 SSFA--PNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATggwRWA-F 157

                        170       180
                 ....*....|....*....|
gi 446414428 172 LILPMITIVTIPFLIKVMVP 191
Cdd:cd17328  158 RVTGVLGVLLAILLLLFVRE 177
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 16-190 1.29e-08

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 56.43  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSlI 95
Cdd:cd17323    1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQ-I 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  96 AFIGHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSY----L 171
Cdd:cd17323   80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWifwfL 159

                        170
                 ....*....|....*....
gi 446414428 172 LILPMITIVTIPFLIKVMV 190
Cdd:cd17323  160 AIISGFCLILIFLFLPIVL 178
PRK14995 PRK14995
SmvA family efflux MFS transporter;
32-409 1.75e-08

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 56.66  E-value: 1.75e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  32 VLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNHFFiLIFGRL 111
Cdd:PRK14995  24 VLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASW-LIATRA 102

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 112 VQGVGSAAF-PSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWS--YLLILPMITIVTIpfLIKV 188
Cdd:PRK14995 103 LLAIGAAMIvPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYWGsvFLINVPIVLVVMG--LTAR 180

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 189 MVPGKS--TKNTLDIVGIVLMSISI--ICFMLFTTNYNWTFLILFTIFFVI-------FIKHISRVSNPFINPKLgknip 257
Cdd:PRK14995 181 YVPRQAgrRDQPLNLGHALMLIVAIllLVYSAKTALKGFLSLWVTSLTLLTgalllglFIRTQLAASRPMIDMRL----- 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 258 FMLGLFSGGLIFSIVAgFISMVPY---MMKTIYHVNVATIGNSVIF--PGTMSVIVFGYFGGFLVDRKGSLFVFILGSLS 332
Cdd:PRK14995 256 FTHRIILSGVVMAMTA-MITLVGFellMAQELQFVHGLSPLEAGMFmlPVMVASGFSGPIAGILVSRLGLRLVATGGMAL 334

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 333 ISISFLTIAfFVEFSM--WLT-TFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGmSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:PRK14995 335 SALSFYGLA-MTDFSTqqWQAwGLMALLGFSAASALLASTSAIMAAAPPEKAAAAG-AIETMAYELGAGLGIAIFGLLLS 412
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 56-173 1.69e-07

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 52.93  E-value: 1.69e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  56 TAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNHFFILIfGRLVQGVGSAAFPSLIMVVVARNITRK 135
Cdd:cd17370  241 ALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLL-GFILWGLYMGAQESIERAAVADLVPAE 319

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446414428 136 KQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLI 173
Cdd:cd17370  320 LRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFL 357
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
36-187 2.47e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 52.61  E-value: 2.47e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  36 SLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI-AFIGHNHFFILIfgRLVQG 114
Cdd:PRK11102  13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVAcALAQTIDQLIYM--RFLHG 90

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446414428 115 VgSAAFPSLIMVVVARNITRKKQ-GKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSY----LLILPMITIVTIPFLIK 187
Cdd:PRK11102  91 L-AAAAASVVINALMRDMFPKEEfSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAifwvLALAAILAAALVFFFIP 167
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 15-408 5.98e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 51.42  E-value: 5.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  15 VLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSL 94
Cdd:cd17319    4 IIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 IAFIGHNHFFILIFgRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLIL 174
Cdd:cd17319   84 LTGFATSLTSLYVL-RFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 175 pmITIVTIPFLIkvmvpgkstkntldIVGIVLMSISIICFMLFTTNYNWTFLILFTIFFVIFIKHISRVSNPFINPklgk 254
Cdd:cd17319  163 --EGLLGLLLAV--------------LWWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAA---- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 255 nIPFMLGLFSgglifSIVAGFISmvpymmktiyhvnvatignSVIFPGTMSVIVFGYFGGFLVdrkGSLFVFILGSLSIS 334
Cdd:cd17319  223 -IPFLAGAIG-----MILGGRLS-------------------DRLLRGARRLVIIIGLLLAAV---GLLLAYLTTSPVVA 274

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446414428 335 ISFLTIAFFvefsmwlttfmfifvmgGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLL 408
Cdd:cd17319  275 VILLSLAGF-----------------GIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLV 331
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
225-453 7.87e-07

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 51.06  E-value: 7.87e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 225 FLILFTIFFVIFIKHISRVSNPFINPK-----LGKNIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNsVI 299
Cdd:COG2211  192 LGLLAFLLTFFGTKERPVPEEEKVSLKeslkaLLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGL-LL 270

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 300 FPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFLTIAFFVEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSE 379
Cdd:COG2211  271 ALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDY 350

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 380 EEVASG-------MSLLNFTSFLSEGTGIAIVGGLLSLQLINRKLVlefinYSSGVYSNILVAMAILIILCCLLTIIVFK 452
Cdd:COG2211  351 DEWKTGrrreglyFGIFTFAIKLGQALAGALAGLLLALFGYVAGAA-----QSPSALTGIRLLFFLLPAVLLLLAALLLL 425


                 .
gi 446414428 453 R 453
Cdd:COG2211  426 F 426
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 18-411 1.11e-06

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 50.27  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  18 WLCILSFFSVLNEMVLNVSLPDIANHFNTtpgitnWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAF 97
Cdd:cd17330    9 ALGFGIVFPVLPFYVREFNKLGASGYYVG------LLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLG 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  98 IGHNhFFILIFGRLVQGVGSAAFpSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYihwsYLLILPMI 177
Cdd:cd17330   83 LSRN-LWLLFLARFLDGLTGGNV-SVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTP----YGYALPFL 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 178 TIVTIPFLikvmvpgkstkntldivGIVLMsisiicfmlfttnynwtFLILFTIFFVIFIkhisrvsnpfinpklgknip 257
Cdd:cd17330  157 VAAALALL-----------------NLVLV-----------------LFFLPPLRRLLLV-------------------- 182

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 258 fmlglfsGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISF 337
Cdd:cd17330  183 -------YFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLLLAIIGL 255

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446414428 338 LTIAfFVEFSMWLTTFMFIFVMGGlSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLSLQ 411
Cdd:cd17330  256 LLLP-FASSVPLLVLAAAILAFGT-GIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFL 327
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 19-405 3.14e-06

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 49.18  E-value: 3.14e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17476    3 ISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGF 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNHFFILIFgRLVQGVGSAAFPSLIMVVVARNITR-KKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSyllilpmi 177
Cdd:cd17476   83 SPNFIFFIIC-RALQGLGPAFLLPNAMALLGRTYPPgPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWP-------- 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 178 tivtipflikvmvpgkstkntldivgivlmsisiicfmlfttnynWTFLILFTIFFVIFIKHISRVSNPFInpklgknip 257
Cdd:cd17476  154 ---------------------------------------------WIFWFLAILAAIVAVAAIFWTSPSFI--------- 179

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 258 fmlglFSGGLIFSIVAGFISMVPYMMKTIYHV--NVATIGNSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISI 335
Cdd:cd17476  180 -----AVLLAVFLGWASFGIWVFYATQYFQNVrgYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLV 254

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446414428 336 SFLTIAF-FVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVG 405
Cdd:cd17476  255 GPILFATmPVHQTYWAQAFPAMIVAPfGMDFSFPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLGIAG 326
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 19-342 3.64e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 48.74  E-value: 3.64e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  19 LCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFI 98
Cdd:cd17489    1 ILLANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  99 GHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHyiHWSYLLIlpMIT 178
Cdd:cd17489   81 ATS-VALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQ--HLGFAVL--FIV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 179 IVTIPFLIKVMVPGKSTKNTLDIVGivlmsisiicfmlfttnynwtflilftiffvifIKHISRVSNPFINPKLgknIPF 258
Cdd:cd17489  156 AAVLALLALLLVFLVKDPPPVAAEE---------------------------------AEAGTRAFRRLVEKKV---LPP 199

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 259 MLGLFSGGLIFSIVAGFISMvpYMMktiyHVNVATIGN-SVIFPGTMsvIVFGYFGGFLVDRKGSLFVFILGSLSISISF 337
Cdd:cd17489  200 ALILFLASIAYGAISTFLPL--YAA----ERGISNAGLfFTVYAIAL--LLSRPFSGKLSDRKGPKTVIIPGLLLLALGL 271


                 ....*
gi 446414428 338 LTIAF 342
Cdd:cd17489  272 LLLSF 276
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 50-409 4.08e-06

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 49.16  E-value: 4.08e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  50 ITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGVGSAAFPSLImVVVA 129
Cdd:cd06179   33 NSTWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKS-VNMLIGGQALIGIGAGTQGLGA-AVAS 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 130 RNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIH----WSYLLILPMITIVTIPFLI------KVMVPGKSTKN-- 197
Cdd:cd06179  111 ELVPNKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagwrWIFYINAIFNALALILLFFfyhpppRPQLHGSSTRQkl 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 198 -TLDIVGIVLMSISIICFMLF----TTNYNWT------FLILFTIFFVIFI--KHISRVSNPFINPKLGKNIPF---MLG 261
Cdd:cd06179  191 kRLDWVGLFLLIAGLVLFLLGlswgGNPYPWSsahviaPLVIGGVLLIAFGlyEWKGTKDGLLPPRLLFRGRNFaliLIV 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 262 LFSGGLIF-SIVAGFISMVPYM-MKTIYHVNVATIGNSVifpgtmSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFLT 339
Cdd:cd06179  271 AFVEGMIFySLNIFWPQQISLLfTTDPLKAGLYQLPFGL------GTLFGAILAGLLLTKIKHIKWQLVAGFVLFTAFLA 344

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446414428 340 IAFFVEFSMWLTTFMFIFVMG-GLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd06179  345 LLALITPDNKALAIAFSVLAGiGIGGPLVLAIVIVQLSVPPEDIGTASGLLGSARALGGAVGTAIFTSILS 415
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
16-167 6.80e-06

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 48.36  E-value: 6.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLP-DIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSL 94
Cdd:COG2211  230 FLLLLLAYLLFFLALALVAALLLyYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLL 309

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 I-AFIGHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNIT-------RKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYI 166
Cdd:COG2211  310 LlFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALF 389


                 .
gi 446414428 167 H 167
Cdd:COG2211  390 G 390
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
37-172 8.99e-06

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 8.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  37 LPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGVG 116
Cdd:COG2807   41 LPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS-VALLLAGTALIGAG 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446414428 117 SAAFPSLIMVVVARNiTRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLL 172
Cdd:COG2807  120 IAVGNVLLPGLIKRW-FPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGAL 174
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 16-409 1.72e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 46.84  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:cd06173    1 FRLLWLAQLLSALGDWIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAV 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  96 AFI----GHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYL 171
Cdd:cd06173   81 LALlallGSLSLWLLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 172 LILPMITIVtipflikvmvpgkstkntldIVGIVLMSISIICFMLFTTNYNWTFLILFTIFFVIFikhisrvsnpfinpk 251
Cdd:cd06173  161 FAINALSFL--------------------LSALLLLFIRRPPPAAPGESSSLLLRDLREGLRYLR--------------- 205

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 252 lgKNIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIFPGTMSVIVfGYFGGFLVDRKGSLFVFILGSL 331
Cdd:cd06173  206 --RSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLG-ALLLGRLSKRRRRGRLLLIGAL 282

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446414428 332 SISISFLTIAFFveFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd06173  283 LLGLALLVLGLS--PSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLAD 358
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 11-187 4.98e-05

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 45.26  E-value: 4.98e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  11 LFYSVLFWLCILSFFSVLNEMVLNVSLPDIANhfnTTPGITNWVNTAYMLTFSIGTA-----VYGKLSDYINIKKLLIIG 85
Cdd:cd17330  171 FFLPPLRRLLLVYFLIALAFAGLESVFSLFLK---DRFGFSPSQIGLLLALVGIAGIlaqllLIPRLAKRLGERKLLRLG 247

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  86 ISLSCLGSLIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGII-AH 164
Cdd:cd17330  248 LLLAIIGLLLLPFASS-VPLLVLAAAILAFGTGIVFPALSALLSKSVPSKEQGKAQGIIQSLQSLARIIGPLLAGPLySF 326

                        170       180
                 ....*....|....*....|...
gi 446414428 165 YIHWSYLLILPMITIVTIPFLIK 187
Cdd:cd17330  327 LGPGVPFLLAAGLLLIALFLLSL 349
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
16-182 6.60e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.84  E-value: 6.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIA-NHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSL 94
Cdd:COG0738  212 LLLGGLAIFLYVGAEGAIGDWLPLYLkDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLL 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 IAFIGHNHFFILIFGRLVqGVGSAAFPSLIMVVVARNItRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLIL 174
Cdd:COG0738  292 LALLAPGPWLALIGLALV-GLGLSLMFPTIFSLALDGL-GKRTAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369


                 ....*...
gi 446414428 175 PMITIVTI 182
Cdd:COG0738  370 PLVCYLLI 377
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
15-151 6.90e-05

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.96  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  15 VLFWLCILSFFSVLNEMVLNVSLPDIA-NHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGs 93
Cdd:COG2814  208 RLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALG- 286

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446414428  94 LIAFIGHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALG 151
Cdd:COG2814  287 LLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 15-189 7.72e-05

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 44.91  E-value: 7.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  15 VLFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSL 94
Cdd:cd06173  210 LRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALL 289

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  95 IAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLIL 174
Cdd:cd06173  290 VLGLSPS-LWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLL 368

                        170
                 ....*....|....*
gi 446414428 175 PMITIVTIPFLIKVM 189
Cdd:cd06173  369 AGALLLLAALLLLLL 383
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
 24-177 1.30e-04

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 44.19  E-value: 1.30e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  24 FFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNHF 103
Cdd:cd17312   13 AAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLW 92

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446414428 104 FILIF---GRLVQGVGSAAfpslIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSYLLILPMI 177
Cdd:cd17312   93 FFAVLwglNGLFQSMGWPP----CVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGI 165
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 10-162 3.28e-04

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 42.93  E-value: 3.28e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  10 GLFYSVLFWL-CILSFFSVLNEMVLNVSLPDIANH-FNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGIS 87
Cdd:cd17321  163 ALLLARTFSGaVLAAFLLGAALGGLLFLLPLYLQGvLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446414428  88 LSCLGS-LIAFIGHNHFFILIFGRL-VQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGII 162
Cdd:cd17321  243 LTAVGLlLLALLGADSSVWLLLPGLvLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
12-204 3.65e-04

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 42.57  E-value: 3.65e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  12 FYSVLFWLCILSffsVLNEMVLNVSLPD---IANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISL 88
Cdd:PRK11043   4 SKGFLVYLAGLS---MLGFLATDMYLPAfkaIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  89 SCLGSLIAFIGHN--HFFILifgRLVQGVG--SAAFPSLIMVvvarnITRKKQGKA---FGFIGSIVALGEGLGPSIGGI 161
Cdd:PRK11043  81 FALGSLGMLWVESaaQLLVL---RFVQAVGvcSAAVIWQALV-----IDRYPAQKAnrvFATIMPLVALSPALAPLLGAW 152

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 446414428 162 IAHYIHW-SYLLILPMITIVTI---PFLIKVMVPGKSTKNTLDIVGI 204
Cdd:PRK11043 153 LLNHFGWqAIFATLFAITLLLIlptLRLKPSKKARKQSQDALTFKQL 199
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 70-392 4.52e-04

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 42.15  E-value: 4.52e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  70 GKLSDYINIKKLLII-GISLSCLGSLIAFIGHNHFFILIF---GRLVQGVGSAAFPSLImvvvARNITRKKQGKAFGFIG 145
Cdd:cd17370   55 GYLSDRTGKRKPLVIlGYGLSALAKPLLALAGSWQLVLLLrilERLGKGIRTPPRDALL----ADATPPSGRGKAFGLHR 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 146 SIVALGEGLGPSIGGIIAHYIHWSY-----LLILPMITIVTIPFLIKVMVPGKSTKNTLDIVGIvlmsisiicfmlfTTN 220
Cdd:cd17370  131 ALDTLGAVLGPLLAALLLYLLGGNYrtiflLAAIPALLALLILLFVVKEYPRPPKLRKKSKKTS-------------LKK 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 221 YNWTFLILFTIFFVifikhisrvsnpfinpklgknipFMLGLFSGGLIfsivagfismvpymmktIYHVNVATIGNSVIf 300
Cdd:cd17370  198 LPKAFWLYLLAVAL-----------------------FALGNFSFAFL-----------------ILRAQELGLSAALI- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 301 PGTMSVI-----VFGYFGGFLVDRKGSLFVFILGSLSISISFLTIAFFVEFSMWLTTFMFIFVmgGLSFTKTVISKIVSS 375
Cdd:cd17370  237 PLLYALFnlvyaLAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGL--YMGAQESIERAAVAD 314

                        330
                 ....*....|....*..
gi 446414428 376 SLSEEEVASGMSLLNFT 392
Cdd:cd17370  315 LVPAELRGTAYGLFNTV 331
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 56-183 4.77e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 42.26  E-value: 4.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  56 TAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNHF-FILIFGrLVQGVGSAAFPSLIMVVVARNITR 134
Cdd:cd17355   45 TVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWqLYLLWG-LLGGGGAGTLAAVAFATVAAWWFE 123

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446414428 135 KKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHW--SYLLILPMITIVTIP 183
Cdd:cd17355  124 RRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWrtALLVLALLALLVLVP 174
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 16-163 6.84e-04

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 41.80  E-value: 6.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:cd17365    1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446414428  96 AFIGHNhFFILIFGRLVQGVG-SAAFPSLIMVVVARNITRKKqgkafGFIGSIVALGEGLGPSIGGIIA 163
Cdd:cd17365   81 TAFAQS-VLQLALLRFLTGLGlGAAMPNAITLVSEYAPARRR-----SLAVTLMFCGYPLGAALGGFLA 143
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 17-154 9.62e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 41.13  E-value: 9.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  17 FWLCILSF-FSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:cd17371    1 FWAAFLGWaLDGFDLLLLGLVLPALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446414428  96 AFIGHNHFFILIFgRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGL 154
Cdd:cd17371   81 CGFAQNYWQLLIL-RALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLL 138
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 32-218 1.45e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 40.62  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  32 VLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLG-SLIAFIghNHFFILIFGR 110
Cdd:cd17478   14 FLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGlSLLGFA--PNYWLLLLLV 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 111 LVQGVGSAAFPSLIMvVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIA--HYIHWSYLLILPMITIVTIPFL--- 185
Cdd:cd17478   92 ALAGIGSAAFHPEGA-RLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALValFGGLGLLILLIIPGLAVALLLLrlr 170

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 446414428 186 ---IKVMVPGKSTKNTLDIVGIVLMSISIICFMLFT 218
Cdd:cd17478  171 plkKPEAKKAAAKSSARSTLKGVWRALLLLLIIVFL 206
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
 58-170 1.45e-03

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 40.62  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  58 YMLTFSIGtavyGKLSDYINIKKLLIIGISL-SCLGSLIAFIGHNHFFILIFGRLVQGVGSA-AFPSLIMVVvARNITRK 135
Cdd:cd17380   47 YALTQVLG----GYLADRFGGKKVLLLAVALwSLATLLTPLLAYSSLPLLILSRILLGLGEGvHFPSMTSLF-SRWVPVS 121

                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446414428 136 KQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHWSY 170
Cdd:cd17380  122 ERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 16-409 2.17e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 40.28  E-value: 2.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFN--TTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGS 93
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFSlgLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  94 LIAFIGHNhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHyihwsylli 173
Cdd:cd17316   81 LLIGLLPT-PILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIP--------- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 174 lpmitivtipflikvmvpgkstkntldivgivlmsisiicfmLFTTNYNWTFLILFTIFFVIFIKHISRvsnpfinpklg 253
Cdd:cd17316  151 ------------------------------------------LLSGDWGWRILFLIGALPALLALLLRR----------- 177

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 254 kniPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNsVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSI 333
Cdd:cd17316  178 ---RTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSL-YLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446414428 334 SISFLTIAFFVEFSMWLTTFMFIFVMGGLSFTKTVISKIVSSSLSEEEVASGMSLLNFTSFLSEGTGIAIVGGLLS 409
Cdd:cd17316  254 GILALPLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLA 329
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 9-174 2.25e-03

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 40.33  E-value: 2.25e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   9 KGLFYSVLFWLCILSFFSVLNEMV-LNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGIS 87
Cdd:cd17355  204 KEALRSASFWLLALAFFLCGFAVVgLIVHLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYA 283

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  88 LSCLGSLIAFIGHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIH 167
Cdd:cd17355  284 LRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTG 363


                 ....*..
gi 446414428 168 wSYLLIL 174
Cdd:cd17355  364 -SYTAAW 369
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 70-163 2.26e-03

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 40.34  E-value: 2.26e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  70 GKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGVgSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVA 149
Cdd:cd17389   85 GAASDVYGRKPVLLLTMIGLAISYALWAVSRS-FTIFLLSRIVGGI-SKGNVSLSTAIVADVTSPKKRSKGMALIGVAFS 162

                         90
                 ....*....|....
gi 446414428 150 LGEGLGPSIGGIIA 163
Cdd:cd17389  163 LGFIIGPMIGAYFA 176
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 70-174 3.37e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 39.51  E-value: 3.37e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  70 GKLSDYINIKKLLI-IGISLSCLGSLIAFIGHNHFFILIfGRLVQGVGSAAFPSlIMVVVARNITRKKQGKAFGFIGSIV 148
Cdd:cd17490   52 GILSDRIGKRKLFIiIGLLFTVLASLIMILFPSPWGLLI-ARFLSGIAAATWVS-FTVLYASYFPPDEAAKAMGLINLVN 129

                         90       100
                 ....*....|....*....|....*.
gi 446414428 149 ALGEGLGPSIGGIIAHYIHWSYLLIL 174
Cdd:cd17490  130 NLGQLIAFLIGGLIAEHFGMRAPFLL 155
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 56-186 3.58e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 39.61  E-value: 3.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   56 TAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNHFFILIFgRLVQGVGSAAFPSLIMVVVARNITRK 135
Cdd:TIGR00898 134 SCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVF-RLLVGMGIGGIWVQAVVLNTEFLPKK 212

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446414428  136 KQGKAFGFIGSIVALGEGLGPsiggIIAHYI-HWSYLLILpmITIVTIPFLI 186
Cdd:TIGR00898 213 QRAIVGTLIQVFFSLGLVLLP----LVAYFIpDWRWLQLA--VSLPTFLFFL 258
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 70-360 4.18e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 39.13  E-value: 4.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  70 GKLSDYINIKKLLIIGISLSCLGsLIAFIGHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVA 149
Cdd:cd17329   56 GRLADRFGRKPVMLAGLLLRALG-FALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAIN 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 150 LGEGLGPSIGGIIAHYIHwsyllilpmitivTIPFLikvmvpgkstkntldivgivlmsISIICFMLFttnynwTFLILF 229
Cdd:cd17329  135 LGVAIGPLLGGLLLLYSF-------------RLLFL-----------------------AAAVLFLLA------ALVLLF 172

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 230 TIFFVIFIKHISRVSNPFINPKL-GKNIPFMLGLFSGGLIFSIVAGFISMVPYMMKTIYHVNVATIGNSVIFPGTMsVIV 308
Cdd:cd17329  173 LLPETRPKRRAAEKTEILRGYKIvLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALL-IVL 251

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446414428 309 FGYFGGFLVDRKGSLFVFILGSLSISISFLTIAFFVEFSMWLtTFMFIFVMG 360
Cdd:cd17329  252 LQFPVARLVERFRLRKILMIGILLFAIGFAVLAFANTLAVLI-LAMIVLTLG 302
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 2-186 4.58e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 39.33  E-value: 4.58e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   2 FSLYKKFKGLFYSVLFWLCILSFFSVLNEMVLNVSLpdiaNHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKL 81
Cdd:cd06174  196 LKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLL----DLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKP 271

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  82 LIIGISLSCLGSLIAFIGHNHFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGI 161
Cdd:cd06174  272 LLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351

                        170       180
                 ....*....|....*....|....*
gi 446414428 162 IAHYIHWSYLLILPMITIVTIPFLI 186
Cdd:cd06174  352 LLAATFGLTGAFLVLAVLLLLAAIL 376
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 21-189 4.73e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.26  E-value: 4.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428   21 ILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGH 100
Cdd:TIGR00895  24 LIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALAT 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  101 NhFFILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHW-SYLLILPMITI 179
Cdd:TIGR00895 104 N-VTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWrSLFYVGGIAPL 182

                         170
                  ....*....|
gi 446414428  180 VTIPFLIKVM 189
Cdd:TIGR00895 183 LLLLLLMRFL 192
MFS_SLCO_OATP cd17336
Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; ...
 16-221 5.70e-03

Solute carrier organic anion transporters of the Major Facilitator Superfamily of transporters; Solute carrier organic anion transporters (SLCOs) are also called organic anion transporting polypeptides (OATPs) or SLC21 (Solute carrier family 21) proteins. They are sodium-independent transporters that mediate the transport of a broad range of endo- as well as xenobiotics. Their substrates are mainly amphipathic organic anions with a molecular weight of more than 300Da, although there are a few known neutral or positively charged substrates. These include drugs including statins, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, antibiotics, antihistaminics, antihypertensives, and anticancer drugs. SLCOs/OATPs can be classified into 6 families (SLCO1-6 or OATP1-6) and each family may have subfamilies (e.g. OATP1A, OATP1B, OATP1C). Within the subfamilies, individual members are numbered according to the chronology of their identification and if there is already an ortholog known, they are given the same number. For example, the first SLCO identified, is rat OATP1A1 (encoded by the Slco1a1 gene). The second SLCO identified is the first human SLCO from the same subfamily and is called OATP1A2 (encoded by the SLCO1A2 gene). There are 11 human SLCOs/OATPs. SLCOs belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340894 [Multi-domain]  Cd Length: 411  Bit Score: 38.76  E-value: 5.70e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  16 LFWLCILSFFSVLNEMVLNVSLPDIANHFNTTPGITNWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLI 95
Cdd:cd17336    5 VVLLCLLGLLQGAVVSYFVSTITTIEKRFGLSSSQSGLILSANDIGQLLAVLLVSYFGGRGHRPRWIGIGSILMGLGCFL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  96 AFIGHnhffILIFGRLVQGVGSAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAH-YIHWS----- 169
Cdd:cd17336   85 LALPH----FLFVGQFLLGIGSSPLYTLGITYIDDNVSKKNSPLYIGILYAMRVLGPALGFLLGSFLLRiYVDFSrvplg 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446414428 170 ---------------YLLILPMITIVTIPFLI--KVMVpgkstkntLDIVGIVLMSISIICFMLFTTNY 221
Cdd:cd17336  161 itpddprwigawwlgFLILGILLLIVSIPLFFfpPIFI--------LLLLAIVFESFAISGFSTFLPKY 221
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 39-363 7.75e-03

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 38.39  E-value: 7.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  39 DIANHFNttpgitnWVNTAYMLTFSIGTAVYGKLSDYINIKKLLIIGISLSCLGSLIAFIGHNhFFILIFGRLVQGVGSA 118
Cdd:cd17388   35 DAATHYG-------VLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPT-LWWLYLGRIIAGITGA 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 119 AFpSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYIHwsyllilpmitivTIPFLikvmvpgkstknt 198
Cdd:cd17388  107 TG-AVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGEISP-------------RAPFL------------- 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 199 ldivgivlmsisiICFMLFTTNYNWTFLILF-TIFFVIFIKHISRVSNPFINPKLGKNIPFMLGLF-SGGLIFSIVAGFI 276
Cdd:cd17388  160 -------------VAAGLNGLNFLLGLFVLPeSLPPERRRAFRWRRANPFGSLRWLTGFPGLLGLLaVFFLIQLIGQVPA 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428 277 SMVPYMMKTIYHVNVATIGNSVIFPGTMSVIVFGYFGGFLVDRKGSLFVFILGSLSISISFLTIAFFVEfSMWLTTFMFI 356
Cdd:cd17388  227 TTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQAFVTGPIAKRLGEKRAILLGLAADALGFLLLAFATQ-GWMVFPILIL 305


                 ....*..
gi 446414428 357 FVMGGLS 363
Cdd:cd17388  306 LALGGIA 312
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 38-166 7.82e-03

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 38.36  E-value: 7.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414428  38 PDIANHFNTTPGITNWVNTAYMLTFSIGTAVYG-KLSDYINIKKLLIIGISLSCLGSLIAFIgHNHFFILIFGRLVQGVG 116
Cdd:cd17490  219 PLIAKQLGASSFQLGLLSIIYLLPNALASLLSGtLFYKKLGERNTIIIGFLLLGAYCFLIPF-APNLTLLYLLQALNGFG 297

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 446414428 117 SAAFPSLIMVVVARNITRKKQGKAFGFIGSIVALGEGLGPSIGGIIAHYI 166
Cdd:cd17490  298 TGILFPLLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAF 347
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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