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Conserved domains on  [gi|446414124|ref|WP_000491979|]
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MULTISPECIES: GNAT family N-acetyltransferase [Staphylococcus]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 11450351)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate

CATH:  3.40.630.30
EC:  2.3.-.-
Gene Ontology:  GO:0016746|GO:0008080
PubMed:  27367672|26818562|15581578|10940244
SCOP:  3000403

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
8-141 1.07e-63

Predicted N-acyltransferase, GNAT family [General function prediction only];


:

Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 190.78  E-value: 1.07e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   8 QEMLEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNEQPVATARIRPINETTVKIERVAVIKSHRGQGIGRMLM 87
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALM 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446414124  88 QAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLT 141
Cdd:COG2153   81 EAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
8-141 1.07e-63

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 190.78  E-value: 1.07e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   8 QEMLEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNEQPVATARIRPINETTVKIERVAVIKSHRGQGIGRMLM 87
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALM 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446414124  88 QAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLT 141
Cdd:COG2153   81 EAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 24-140 1.16e-20

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 81.16  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   24 EEQGVPEESEIDEYESESIHLIGYDNEQPVATARIRpineTTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYVA- 102
Cdd:pfam13673  14 YEFISPEALRERIDQGEYFFFVAFEGGQIVGVIALR----DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSe 89

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446414124  103 -TMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKL 140
Cdd:pfam13673  90 lTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEKEL 128
PRK10314 PRK10314
GNAT family N-acetyltransferase;
11-139 7.98e-15

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 66.79  E-value: 7.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124  11 LEDCFYIRKKVFVEEQGVP-EESEIDEYESESIHLIGYDNEQPVATARIRPINETT--VKIERVAVIKSHRGQGIGRMLM 87
Cdd:PRK10314  17 LYALLQLRCAVFVVEQNCPyQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLepVVIGRVIVSEALRGEKVGQQLM 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446414124  88 -QAVESLAK---DEGFYvatMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKK 139
Cdd:PRK10314  97 sKTLESCTRhwpDKPVY---LGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMARE 149
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-99 3.85e-11

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 54.97  E-value: 3.85e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446414124  43 HLIGYDNEQPVATARIRPIN--ETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGF 99
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 11-123 2.70e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.46  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   11 LEDCFYIRKKVFVEEQgvPEESEIDEYESESIHLIG-YDNEQPVATARIRpINETTVKIERVAVIKSHRGQGIGRMLMQA 89
Cdd:TIGR01575   2 LKAVLEIEAAAFAFPW--TEAQFAEELANYHLCYLLaRIGGKVVGYAGVQ-IVLDEAHILNIAVKPEYQGQGIGRALLRE 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446414124   90 VESLAKDEG-----FYVATMNAQchAIPFYESLNFKMRG 123
Cdd:TIGR01575  79 LIDEAKGRGvneifLEVRVSNIA--AQALYKKLGFNEIA 115
 
Name Accession Description Interval E-value
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
8-141 1.07e-63

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 190.78  E-value: 1.07e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   8 QEMLEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNEQPVATARIRPINETTVKIERVAVIKSHRGQGIGRMLM 87
Cdd:COG2153    1 AEELYDALALRREVFVVEQGVPPYLELDGKDEDARHLLAYDDGELVATARLLPPGDGEAKIGRVAVLPEYRGQGLGRALM 80

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446414124  88 QAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLT 141
Cdd:COG2153   81 EAAIEEARERGARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 24-140 1.16e-20

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 81.16  E-value: 1.16e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   24 EEQGVPEESEIDEYESESIHLIGYDNEQPVATARIRpineTTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYVA- 102
Cdd:pfam13673  14 YEFISPEALRERIDQGEYFFFVAFEGGQIVGVIALR----DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLSe 89

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446414124  103 -TMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKKL 140
Cdd:pfam13673  90 lTVNASPYAVPFYEKLGFRATGPEQEFNGIRFVPMEKEL 128
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 33-120 2.29e-19

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 78.17  E-value: 2.29e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124  33 EIDEYESESIHLIGYDNEQPVATARIRPINETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEG---FYVATMNAQCH 109
Cdd:COG0454   26 AMEGSLAGAEFIAVDDKGEPIGFAGLRRLDDKVLELKRLYVLPEYRGKGIGKALLEALLEWARERGctaLELDTLDGNPA 105

                         90
                 ....*....|.
gi 446414124 110 AIPFYESLNFK 120
Cdd:COG0454  106 AIRFYERLGFK 116
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 11-119 6.15e-18

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 74.09  E-value: 6.15e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   11 LEDCFYIRKKVFVEEQGVPEESEIDEYE--SESIHLIGYDNEQPVATARIRPINET--TVKIERVAVIKSHRGQGIGRML 86
Cdd:pfam00583   1 LEALYELLSEEFPEPWPDEPLDLLEDWDedASEGFFVAEEDGELVGFASLSIIDDEppVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446414124   87 MQAVESLAKDEGF---YVATMNAQCHAIPFYESLNF 119
Cdd:pfam00583  81 LQALLEWARERGCeriFLEVAADNLAAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 39-120 1.53e-17

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 72.10  E-value: 1.53e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   39 SESIHLIGYDNEQPVATARIRPINETTVKIE-RVAVIKSHRGQGIGRMLMQAVESLAKDEGFYVATMNAQCHAIPFYESL 117
Cdd:pfam13508   1 PGGRFFVAEDDGKIVGFAALLPLDDEGALAElRLAVHPEYRGQGIGRALLEAAEAAAKEGGIKLLELETTNRAAAFYEKL 80


                  ...
gi 446414124  118 NFK 120
Cdd:pfam13508  81 GFE 83
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
33-140 1.54e-17

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 73.58  E-value: 1.54e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124  33 EIDEYESESIHLIGYDNEQPVATARIRPI----NETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYVATMNAQC 108
Cdd:COG3153   31 RLREDPAAGLSLVAEDDGEIVGHVALSPVdidgEGPALLLGPLAVDPEYRGQGIGRALMRAALEAARERGARAVVLLGDP 110

                         90       100       110
                 ....*....|....*....|....*....|..
gi 446414124 109 HAIPFYESLNFKMRGNIFLEEGIEHIEMTKKL 140
Cdd:COG3153  111 SLLPFYERFGFRPAGELGLTLGPDEVFLAKEL 142
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 48-120 1.64e-15

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 68.09  E-value: 1.64e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446414124  48 DNEQPVATARIRPINETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGF---YVATMNAqchAIPFYESLNFK 120
Cdd:COG1246   35 EDGEIVGCAALHPLDEDLAELRSLAVHPDYRGRGIGRRLLEALLAEARELGLkrlFLLTTSA---AIHFYEKLGFE 107
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 68-141 2.72e-15

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 66.60  E-value: 2.72e-15
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446414124  68 IERVAVIKSHRGQGIGRMLMQAVESLAKDEGF-----YVATMNAQchAIPFYESLNFKMRGNIFLEEGIEHIEMTKKLT 141
Cdd:COG0456   16 IEDLAVDPEYRGRGIGRALLEAALERARERGArrlrlEVREDNEA--AIALYEKLGFEEVGERPNYYGDDALVMEKELA 92
PRK10314 PRK10314
GNAT family N-acetyltransferase;
11-139 7.98e-15

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 66.79  E-value: 7.98e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124  11 LEDCFYIRKKVFVEEQGVP-EESEIDEYESESIHLIGYDNEQPVATARIRPINETT--VKIERVAVIKSHRGQGIGRMLM 87
Cdd:PRK10314  17 LYALLQLRCAVFVVEQNCPyQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLepVVIGRVIVSEALRGEKVGQQLM 96

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 446414124  88 -QAVESLAK---DEGFYvatMNAQCHAIPFYESLNFKMRGNIFLEEGIEHIEMTKK 139
Cdd:PRK10314  97 sKTLESCTRhwpDKPVY---LGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMARE 149
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
51-123 3.77e-13

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 60.69  E-value: 3.77e-13
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446414124  51 QPVATARIRPINETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGF-----YVATMNAQchAIPFYESLNFKMRG 123
Cdd:COG3393    1 ELVAMAGVRAESPGVAEISGVYTHPEYRGRGLASALVAALAREALARGArtpflYVDADNPA--ARRLYERLGFRPVG 76
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 43-99 3.85e-11

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 54.97  E-value: 3.85e-11
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446414124  43 HLIGYDNEQPVATARIRPIN--ETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGF 99
Cdd:cd04301    1 FLVAEDDGEIVGFASLSPDGsgGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARERGA 59
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
48-123 3.38e-10

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 55.00  E-value: 3.38e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124  48 DNEQPVATA-----RIRPINETTVkIERVAVIKSHRGQGIGRMLMQAVESLAKDEGFyvATMNAQCH-----AIPFYESL 117
Cdd:COG1247   59 EDGEVVGFAslgpfRPRPAYRGTA-EESIYVDPDARGRGIGRALLEALIERARARGY--RRLVAVVLadneaSIALYEKL 135


                 ....*.
gi 446414124 118 NFKMRG 123
Cdd:COG1247  136 GFEEVG 141
Eis COG4552
Predicted acetyltransferase [General function prediction only];
29-103 9.28e-06

Predicted acetyltransferase [General function prediction only];


Pssm-ID: 443616 [Multi-domain]  Cd Length: 393  Bit Score: 43.73  E-value: 9.28e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124  29 PEESEIDEYESESIHLIgYDNEQPVATARIRP----INETTVK---IERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYV 101
Cdd:COG4552   30 ELEAYRPLLEPGRVLGV-FDDGELVGTLALYPftlnVGGARVPmagITGVAVAPEHRRRGVARALLREALAELRERGQPL 108


                 ..
gi 446414124 102 AT 103
Cdd:COG4552  109 SA 110
PTZ00330 PTZ00330
acetyltransferase; Provisional
 68-124 3.75e-05

acetyltransferase; Provisional


Pssm-ID: 140351 [Multi-domain]  Cd Length: 147  Bit Score: 40.98  E-value: 3.75e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446414124  68 IERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYVATMNAQCHAIPFYESLNFKMRGN 124
Cdd:PTZ00330  85 IEDVVVDPSYRGQGLGRALISDLCEIARSSGCYKVILDCTEDMVAFYKKLGFRACER 141
PRK10975 PRK10975
dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;
59-103 1.96e-04

dTDP-4-amino-4,6-dideoxy-D-galactose acyltransferase;


Pssm-ID: 182877  Cd Length: 194  Bit Score: 39.53  E-value: 1.96e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446414124  59 RPINETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGF---YVAT 103
Cdd:PRK10975 120 RELNDTDARIGLLAVFPGAQGRGIGARLMQAALNWCQARGLtrlRVAT 167
rimI TIGR01575
ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related ...
 11-123 2.70e-04

ribosomal-protein-alanine acetyltransferase; Members of this model belong to the GCN5-related N-acetyltransferase (GNAT) superfamily. This model covers prokarotes and the archaea. The seed contains a characterized accession for Gram negative E. coli. An untraceable characterized accession (PIR|S66013) for Gram positive B. subtilis scores well (205.0) in the full alignment. Characterized members are lacking in the archaea. Noise cutoff (72.4) was set to exclude M. loti paralog of rimI. Trusted cutoff (80.0) was set at next highest scoring member in the mini-database. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273701 [Multi-domain]  Cd Length: 131  Bit Score: 38.46  E-value: 2.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   11 LEDCFYIRKKVFVEEQgvPEESEIDEYESESIHLIG-YDNEQPVATARIRpINETTVKIERVAVIKSHRGQGIGRMLMQA 89
Cdd:TIGR01575   2 LKAVLEIEAAAFAFPW--TEAQFAEELANYHLCYLLaRIGGKVVGYAGVQ-IVLDEAHILNIAVKPEYQGQGIGRALLRE 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 446414124   90 VESLAKDEG-----FYVATMNAQchAIPFYESLNFKMRG 123
Cdd:TIGR01575  79 LIDEAKGRGvneifLEVRVSNIA--AQALYKKLGFNEIA 115
PRK07757 PRK07757
N-acetyltransferase;
71-98 2.81e-04

N-acetyltransferase;


Pssm-ID: 236088 [Multi-domain]  Cd Length: 152  Bit Score: 38.64  E-value: 2.81e-04
                         10        20
                 ....*....|....*....|....*...
gi 446414124  71 VAVIKSHRGQGIGRMLMQAVESLAKDEG 98
Cdd:PRK07757  71 LAVSEDYRGQGIGRMLVEACLEEARELG 98
COG3818 COG3818
Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];
68-99 4.64e-04

Predicted N-acetyltransferase, GNAT superfamily [General function prediction only];


Pssm-ID: 443030 [Multi-domain]  Cd Length: 168  Bit Score: 38.38  E-value: 4.64e-04
                         10        20        30
                 ....*....|....*....|....*....|..
gi 446414124  68 IERVAVIKSHRGQGIGRMLMQAVESLAKDEGF 99
Cdd:COG3818   87 IDRIVVAPSARGRGLGRALYADVFSYARARGV 118
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 11-119 5.35e-04

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 37.55  E-value: 5.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446414124   11 LEDCFYIRKKVFVEEQGVPEESEIDEYESESIHLIGYDNEQPVATARIRP----INETTVK---IERVAVIKSHRGQGIG 83
Cdd:pfam13527   9 FDEVLRLLEYAFQDEDSPELREYFRPLLEEGRVLGAFDDGELVSTLALYPfelnVPGKTLPaagITGVATYPEYRGRGVM 88

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 446414124   84 RMLMQAVESLAKDEGFYVATMNAqcHAIPFYESLNF 119
Cdd:pfam13527  89 SRLLRRSLEEMRERGVPLSFLYP--SSYPIYRRFGY 122
PRK10514 PRK10514
putative acetyltransferase; Provisional
 76-123 7.80e-04

putative acetyltransferase; Provisional


Pssm-ID: 182510 [Multi-domain]  Cd Length: 145  Bit Score: 37.29  E-value: 7.80e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*...
gi 446414124  76 SHRGQGIGRMLMQAVESLAKDEGFYVATMNAQchAIPFYESLNFKMRG 123
Cdd:PRK10514  80 DVRGCGVGRMLVEHALSLHPELTTDVNEQNEQ--AVGFYKKMGFKVTG 125
exosort_acyl TIGR03694
N-acyl amino acid synthase, PEP-CTERM/exosortase system-associated; Members of this protein ...
 6-63 1.14e-03

N-acyl amino acid synthase, PEP-CTERM/exosortase system-associated; Members of this protein family are restricted to bacterial species with the PEP-CTERM/exosortase system predicted to act in exopolysaccharide-associated protein targeting. PSI-BLAST and CDD reveal relationships to the acyltransferase family that includes N-acyl-L-homoserine lactone synthetase, and recent work shows long-chain N-acyl amino acid biosynthesis activity. Several members of this family may be found in a single genome. These acyltransferases may produce a quorum signalling molecule or may contribute to chemical modifications in exopolysaccharide and biofilm structural material production.


Pssm-ID: 274728  Cd Length: 241  Bit Score: 37.70  E-value: 1.14e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446414124    6 NNQEMLEDCFYIRKKVFVEEQG------VPEESEIDEYESESIH-LIGY-DNEQPVATARIRPINE 63
Cdd:TIGR03694  14 VTPELLEEAFRLRYQVYCEELGfeppsdYPDGLETDEYDAHSVHsLLRHrRTGTFVGCVRLVLPNS 79
Acetyltransf_5 pfam13444
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 17-60 4.12e-03

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions.


Pssm-ID: 463880  Cd Length: 102  Bit Score: 34.51  E-value: 4.12e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 446414124   17 IRKKVFVEE-----QGVPEESEIDEYESESIHLIGYDNE--QPVATARIRP 60
Cdd:pfam13444   1 LRYRVFREEmgatgPAALPGLDIDRFDAYCDHLLVWDDDtgEVVGTYRLLP 51
Acetyltransf_CG pfam14542
GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both ...
 45-101 4.50e-03

GCN5-related N-acetyl-transferase; This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterized by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.


Pssm-ID: 434030 [Multi-domain]  Cd Length: 79  Bit Score: 34.03  E-value: 4.50e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446414124   45 IGYDNEQPVATARIRpINETTVKIERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYV 101
Cdd:pfam14542   4 IRVDGGAEVAFLTYR-RGDGVLIITHTEVPPALRGQGIASKLVKAALDDAREEGLKI 59
PRK01346 PRK01346
enhanced intracellular survival protein Eis;
37-106 6.85e-03

enhanced intracellular survival protein Eis;


Pssm-ID: 234945 [Multi-domain]  Cd Length: 411  Bit Score: 35.29  E-value: 6.85e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446414124  37 YESESIHLIgYDNEQPVATARIRPInETTVK---------IERVAVIKSHRGQGIGRMLMQAVESLAKDEGFYVATMNA 106
Cdd:PRK01346  44 VEPDRTLGA-FDGDEVVGTAGAFDL-RLTVPggavlpaagVTAVTVAPTHRRRGLLTALMREQLRRIRERGEPVAALTA 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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