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Conserved domains on  [gi|446411886|ref|WP_000489741|]
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methyl viologen efflux MFS transporter SmvA [Salmonella enterica]

Protein Classification

MFS transporter( domain architecture ID 11487555)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK14995 PRK14995
SmvA family efflux MFS transporter;
1-495 0e+00

SmvA family efflux MFS transporter;


:

Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 748.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
Cdd:PRK14995   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  81 FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW 160
Cdd:PRK14995  81 FGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 161 GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGNLSLWAISLTLLTGTLLLGLFL 240
Cdd:PRK14995 161 GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 241 RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVS 320
Cdd:PRK14995 241 RTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGA 400
Cdd:PRK14995 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGA 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 401 GLGIAIFGLLLSRSFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARHAFIWSHSVALSSAGSMLLL 480
Cdd:PRK14995 401 GLGIAIFGLLLSRSYSASIRLPAGLPAQLIEKASSSIGEAVQLANSLPPTLGQALLDAAKQAFIWSHSVVLSSAGSMLLL 480
                        490
                 ....*....|....*
gi 446411886 481 LAVGMWFSLAKAQRR 495
Cdd:PRK14995 481 LAVGVWFSLAKAQRR 495
 
Name Accession Description Interval E-value
PRK14995 PRK14995
SmvA family efflux MFS transporter;
1-495 0e+00

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 748.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
Cdd:PRK14995   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  81 FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW 160
Cdd:PRK14995  81 FGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 161 GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGNLSLWAISLTLLTGTLLLGLFL 240
Cdd:PRK14995 161 GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 241 RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVS 320
Cdd:PRK14995 241 RTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGA 400
Cdd:PRK14995 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGA 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 401 GLGIAIFGLLLSRSFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARHAFIWSHSVALSSAGSMLLL 480
Cdd:PRK14995 401 GLGIAIFGLLLSRSYSASIRLPAGLPAQLIEKASSSIGEAVQLANSLPPTLGQALLDAAKQAFIWSHSVVLSSAGSMLLL 480
                        490
                 ....*....|....*
gi 446411886 481 LAVGMWFSLAKAQRR 495
Cdd:PRK14995 481 LAVGVWFSLAKAQRR 495
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
11-438 1.94e-60

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 202.79  E-value: 1.94e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  11 IVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAF 90
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  91 SHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPI 170
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 171 VLVVMGLTaryvprqagrrdqplnlghavmliiailllvysaktalkgnlslwaisltlltgtlllglflrtqlatsrpm 250
Cdd:cd17321  160 GLVALLLA------------------------------------------------------------------------ 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 251 idmrlfthRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATG 330
Cdd:cd17321  168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 331 GMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLL 410
Cdd:cd17321  240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
                        410       420
                 ....*....|....*....|....*...
gi 446411886 411 LSRSFSASIRLPAGLEAQEIARASSSMG 438
Cdd:cd17321  320 LTAGLSANLGDSGVAALLSAAAAAFAAG 347
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
6-487 8.42e-36

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 139.05  E-value: 8.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886    6 LTLVIIVLVYIPVaIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
Cdd:TIGR00711   3 LTIVLMLGTFMAV-LDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   86 LAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFL 165
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK-RGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  166 INVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALK-GNLSLWAISLTLLTGTLLLGLFLRTQL 244
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPErGWFDSNEILILSITGLVAIIAFVVWEL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  245 ATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGL 324
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  325 RLVATGGMALSALSFYGLAMT-DFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLG 403
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIG 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  404 IAIFGLLLSR------SFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAildaarHAFIWSHSVALSSAGSM 477
Cdd:TIGR00711 401 TALITTILTNrtqfhhSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITL------HAFSIAINEIFWMATLL 474
                         490
                  ....*....|
gi 446411886  478 LLLLAVGMWF 487
Cdd:TIGR00711 475 FVSGLILIWF 484
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
3-283 9.20e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 106.82  E-value: 9.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:COG0477   11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  83 LASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGS 162
Cdd:COG0477   91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 163 VFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGNLSLWAISLTLLTGTLLLGLFLRT 242
Cdd:COG0477  170 IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446411886 243 QLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMA 283
Cdd:COG0477  250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
MFS_1 pfam07690
Major Facilitator Superfamily;
27-403 3.36e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 76.69  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   27 VAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAI 106
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  107 GAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQA 186
Cdd:pfam07690  98 GAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  187 GRRDQPlnlghavmlIIAILLLVYSAKTALKGNLSLWAIsltlltgtlllglflrtqlatsrpmidmrlfthrIILSGVV 266
Cdd:pfam07690 177 SKRPKP---------AEEARLSLIVAWKALLRDPVLWLL----------------------------------LALLLFG 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  267 MAMTAMITLVGFellmaqeLQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATGGMALSALSFYGLAMTD 346
Cdd:pfam07690 214 FAFFGLLTYLPL-------YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446411886  347 FSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLG 403
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
 
Name Accession Description Interval E-value
PRK14995 PRK14995
SmvA family efflux MFS transporter;
1-495 0e+00

SmvA family efflux MFS transporter;


Pssm-ID: 184957 [Multi-domain]  Cd Length: 495  Bit Score: 748.86  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
Cdd:PRK14995   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  81 FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW 160
Cdd:PRK14995  81 FGLASLAAAFSPTASWLIATRALLAIGAAMIVPATLAGIRATFTEEKQRNMALGVWAAVGSGGAAFGPLVGGILLEHFYW 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 161 GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGNLSLWAISLTLLTGTLLLGLFL 240
Cdd:PRK14995 161 GSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHALMLIVAILLLVYSAKTALKGFLSLWVTSLTLLTGALLLGLFI 240
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 241 RTQLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVS 320
Cdd:PRK14995 241 RTQLAASRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVS 320
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGA 400
Cdd:PRK14995 321 RLGLRLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGA 400
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 401 GLGIAIFGLLLSRSFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAILDAARHAFIWSHSVALSSAGSMLLL 480
Cdd:PRK14995 401 GLGIAIFGLLLSRSYSASIRLPAGLPAQLIEKASSSIGEAVQLANSLPPTLGQALLDAAKQAFIWSHSVVLSSAGSMLLL 480
                        490
                 ....*....|....*
gi 446411886 481 LAVGMWFSLAKAQRR 495
Cdd:PRK14995 481 LAVGVWFSLAKAQRR 495
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
11-438 1.94e-60

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 202.79  E-value: 1.94e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  11 IVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAF 90
Cdd:cd17321    1 LLLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  91 SHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPI 170
Cdd:cd17321   81 APSLAFLIAARALQGIGAAAIMPASLALIAATF-PGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPI 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 171 VLVVMGLTaryvprqagrrdqplnlghavmliiailllvysaktalkgnlslwaisltlltgtlllglflrtqlatsrpm 250
Cdd:cd17321  160 GLVALLLA------------------------------------------------------------------------ 167
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 251 idmrlfthRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATG 330
Cdd:cd17321  168 --------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVA 239
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 331 GMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLL 410
Cdd:cd17321  240 GLLLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGAL 319
                        410       420
                 ....*....|....*....|....*...
gi 446411886 411 LSRSFSASIRLPAGLEAQEIARASSSMG 438
Cdd:cd17321  320 LTAGLSANLGDSGVAALLSAAAAAFAAG 347
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
6-487 8.42e-36

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 139.05  E-value: 8.42e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886    6 LTLVIIVLVYIPVaIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
Cdd:TIGR00711   3 LTIVLMLGTFMAV-LDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGS 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   86 LAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFL 165
Cdd:TIGR00711  82 LLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEK-RGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  166 INVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALK-GNLSLWAISLTLLTGTLLLGLFLRTQL 244
Cdd:TIGR00711 161 INVPIGIIVVVVAFFILPRDKPAASENFDFLGLLLLSVGLGSLLYGLSEGPErGWFDSNEILILSITGLVAIIAFVVWEL 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  245 ATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGL 324
Cdd:TIGR00711 241 TDDNPLVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDP 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  325 RLVATGGMALSALSFYGLAMT-DFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLG 403
Cdd:TIGR00711 321 RKLVTIGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIG 400
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  404 IAIFGLLLSR------SFSASIRLPAGLEAQEIARASSSMGEAVQLANSLPPTQGQAildaarHAFIWSHSVALSSAGSM 477
Cdd:TIGR00711 401 TALITTILTNrtqfhhSQLTETINPVNPNFLSGYSQLAALGNPEQQVYALIAQQITL------HAFSIAINEIFWMATLL 474
                         490
                  ....*....|
gi 446411886  478 LLLLAVGMWF 487
Cdd:TIGR00711 475 FVSGLILIWF 484
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
19-438 1.50e-35

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 136.17  E-value: 1.50e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLI 98
Cdd:cd17503    9 ILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  99 ATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVlvvmglt 178
Cdd:cd17503   89 IFRILQGFGGGVLIPLAQTILLRIYPPEK-RGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG------- 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 179 aryvprqagrrdqplnlghavmlIIAILLLvysaktalkgnlslwaisltlltgtlllglflrtqlatsrPMIDMRLFTH 258
Cdd:cd17503  161 -----------------------ILALLLA----------------------------------------PLLDLRLFKD 177
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 259 RIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATGGMALSALS 338
Cdd:cd17503  178 RNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGLLLLALG 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 339 FYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSFSAS 418
Cdd:cd17503  258 TLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLTNRTQFH 337
                        410       420
                 ....*....|....*....|
gi 446411886 419 IRLPAGLEAQEIARASSSMG 438
Cdd:cd17503  338 HSRLSELLAQQVQKQALIIA 357
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
3-283 9.20e-26

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 106.82  E-value: 9.20e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:COG0477   11 RRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFG 90
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  83 LASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGS 162
Cdd:COG0477   91 LASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELF-PARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRW 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 163 VFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGNLSLWAISLTLLTGTLLLGLFLRT 242
Cdd:COG0477  170 IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLA 249
                        250       260       270       280
                 ....*....|....*....|....*....|....*....|.
gi 446411886 243 QLATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMA 283
Cdd:COG0477  250 LLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLL 290
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-377 7.54e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 105.44  E-value: 7.54e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:COG2814    7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  83 LASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGS 162
Cdd:COG2814   87 LGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLV-PPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRW 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 163 VFLINVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAvmliiailllvysaktalkgnlslwaisltlltgtlllglflrt 242
Cdd:COG2814  166 VFLVNAVLALLALLLLLRLLPESRPAARARLRGSLR-------------------------------------------- 201
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 243 qlatsrpmidmRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRL 322
Cdd:COG2814  202 -----------ELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRF 270
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446411886 323 GLRLVATGGMALSALSFYGLAmtdFSTQQWQAWGLMALLGFSAASALLASTSAIM 377
Cdd:COG2814  271 GRRRLLLIGLLLLALGLLLLA---LAGSLWLLLLALFLLGFGFGLLFPLLQALVA 322
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
18-406 5.01e-22

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 96.86  E-value: 5.01e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  18 VAIDATVLHVAAPTLSMTLGaSGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWL 97
Cdd:cd17502    8 AALDQTIVATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTML 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  98 IATRVLLAIGAAMIVPATLAgIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVlvvmgl 177
Cdd:cd17502   87 IVGRAIQGIGGGGLMSLAFI-IIADLVPPRERGKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYINLPIG------ 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 178 taryvprqagrrdqplnlghavmlIIAILLLvysaktalkgnlslwaisltlltgtlllglflrtqlatsrpmidmrlft 257
Cdd:cd17502  160 ------------------------GLALALL------------------------------------------------- 166
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 258 hRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLG-LRLVATGGMALSA 336
Cdd:cd17502  167 -RTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGrYKPLIVIGTILMS 245
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 337 LSFYGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAI 406
Cdd:cd17502  246 VGAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAI 315
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-178 1.32e-19

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 90.31  E-value: 1.32e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:COG2271    7 YRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  83 LASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGS 162
Cdd:COG2271   87 LATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWF-PPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRA 165
                        170
                 ....*....|....*.
gi 446411886 163 VFLINVPIVLVVMGLT 178
Cdd:COG2271  166 AFLILGLPGLLLALLR 181
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
30-413 3.97e-19

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 88.79  E-value: 3.97e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  30 PTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAA 109
Cdd:cd17325   20 PLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASA 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 110 MIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGRR 189
Cdd:cd17325  100 AVWPAAMALIADIA-PPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 190 DqplnlghavmliiailllvysaktalkgnlslwaisltlltgtlllglFLRTQLATSRPMIDMRLFTHRIILSGvVMAM 269
Cdd:cd17325  179 N------------------------------------------------KRAVSAARLRSGLRLLLRDRRLLALF-LAIF 209
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 270 TAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATGGMALSALSFYGLAmtdFST 349
Cdd:cd17325  210 VLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLP---LAT 286
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446411886 350 QQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSR 413
Cdd:cd17325  287 SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDA 350
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
12-412 1.69e-18

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 86.86  E-value: 1.69e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  12 VLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFS 91
Cdd:cd17504    2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  92 HTASWLIATRVLLAIGAAMiVPATLAGIRATFCEEKHRnMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIV 171
Cdd:cd17504   82 PNLPVLIAGRALQGIGGAV-FPLAFALVREEFPPERVP-VAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 172 LVVMGLTaryvprqagrrdqplnlghavmliiailllvysaktalkgnlslwaisltlltgtlllglflrtqlatsrPMI 251
Cdd:cd17504  160 VLLAALV----------------------------------------------------------------------PLI 169
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 252 DMRLFTHRIIL----SGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLV 327
Cdd:cd17504  170 DLRLLRRRNVLlaniTALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRV 249
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 328 ATGGMALSALSFYGLAMtdFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIF 407
Cdd:cd17504  250 LLIGLVISAVGLLLLAL--LHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIA 327

                 ....*
gi 446411886 408 GLLLS 412
Cdd:cd17504  328 GAILT 332
PRK10504 PRK10504
putative transporter; Provisional
19-344 6.24e-18

putative transporter; Provisional


Pssm-ID: 182502 [Multi-domain]  Cd Length: 471  Bit Score: 86.32  E-value: 6.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLI 98
Cdd:PRK10504  23 SLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELL 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  99 ATRVLLAIGAAMIVPATlagiRATFCEEKHRNMALGVWAAV---GSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVM 175
Cdd:PRK10504 103 LARVLQGVGGAMMVPVG----RLTVMKIVPREQYMAAMTFVtlpGQVGPLLGPALGGLLVEYASWHWIFLINIPVGIIGA 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 176 GLTARYVPRQAgRRDQPLNLGHAVMLIIAILLLVYSAKTALKGNLSLWAISLTLLTGTLLLGLFLRTQLATSRPMIDMRL 255
Cdd:PRK10504 179 IATLMLMPNYT-MQTRRFDLSGFLLLAVGMATLTLALDGSKGLGLSPLAIAGLVAVGVVALLLYLLHARNNNRALFSLKL 257
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 256 FTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLV---ATGGM 332
Cdd:PRK10504 258 FRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRVlvaTTLGL 337
                        330
                 ....*....|..
gi 446411886 333 ALSALSFYGLAM 344
Cdd:PRK10504 338 ALVSLLFMLVAL 349
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
27-181 1.32e-17

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 84.24  E-value: 1.32e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  27 VAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAI 106
Cdd:cd17476   19 VILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGL 98
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446411886 107 GAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVpIVLVVMGLTARY 181
Cdd:cd17476   99 GPAFLLPNAMALLGRTYPPGPRKNIVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWFLA-ILAAIVAVAAIF 172
MFS_1 pfam07690
Major Facilitator Superfamily;
27-403 3.36e-15

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 76.69  E-value: 3.36e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   27 VAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAI 106
Cdd:pfam07690  18 ALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGL 97
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  107 GAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQA 186
Cdd:pfam07690  98 GAGALFPAALALIADWF-PPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPE 176
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  187 GRRDQPlnlghavmlIIAILLLVYSAKTALKGNLSLWAIsltlltgtlllglflrtqlatsrpmidmrlfthrIILSGVV 266
Cdd:pfam07690 177 SKRPKP---------AEEARLSLIVAWKALLRDPVLWLL----------------------------------LALLLFG 213
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  267 MAMTAMITLVGFellmaqeLQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATGGMALSALSFYGLAMTD 346
Cdd:pfam07690 214 FAFFGLLTYLPL-------YQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLS 286
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 446411886  347 FSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLG 403
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
30-414 1.25e-14

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 75.30  E-value: 1.25e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  30 PTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAA 109
Cdd:cd17474   23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 110 MIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEhFYWGSVFLINVPIVLVVMGLTARYVPRQAGRR 189
Cdd:cd17474  103 GLGPLALTLIGDLF-EGGERAKAMGLYEAALGLGIAVGPLLGGLLAA-ISWRYPFFLLAALIPVAFLAILFLLPEPKEKA 180
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 190 DQPLNLGHAVMLiiailllvysaktalkgnlslwaisltlltgtlllglflrtqlatsrpmidmRLFTHRIILSGVVMAM 269
Cdd:cd17474  181 KSSSATKLRDLK----------------------------------------------------KALRGRGLLTFLVSAF 208
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 270 TAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVS-RLGLRLVATGGMALSALSFYGLAmtdFS 348
Cdd:cd17474  209 LYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLLLLG---FV 285
                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446411886 349 TQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSRS 414
Cdd:cd17474  286 PSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIF 351
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
3-419 7.10e-14

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 72.99  E-value: 7.10e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:COG2223    2 GRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLG 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  83 LASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGS 162
Cdd:COG2223   82 IGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF-PPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 163 VFLINVPIVLVVMGLTARYVPRQAGRRDQPlnlghavmliiailllvysaktalkgnlslwaisltlltgtlllglflrt 242
Cdd:COG2223  161 AFLILGILLLVVAVLAWLFLRDPPAGAAAA-------------------------------------------------- 190
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 243 qlATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRL 322
Cdd:COG2223  191 --AKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRI 268
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 323 GLRLVATGGMALSALSFYGLAMTDFSTqqWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGL 402
Cdd:COG2223  269 GGRRVLLIVFALMALGLLLLALALGSL--WLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFL 346
                        410
                 ....*....|....*..
gi 446411886 403 GIAIFGLLLSRSFSASI 419
Cdd:COG2223  347 GPLLFGALLDATGSYTA 363
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
3-183 8.75e-13

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 69.69  E-value: 8.75e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886    3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:TIGR00895  14 YQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFS 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   83 LASLAAAFSHTASWLIATRVL--LAIGAAMIVPATLAgirATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW 160
Cdd:TIGR00895  94 VFTLLCALATNVTQLLILRFLagLGLGGLMPNLNALV---SEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGW 170
                         170       180
                  ....*....|....*....|...
gi 446411886  161 GSVFLINVPIVLVVMGLTARYVP 183
Cdd:TIGR00895 171 RSLFYVGGIAPLLLLLLLMRFLP 193
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
36-182 6.29e-12

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 67.22  E-value: 6.29e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  36 LGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPAT 115
Cdd:cd17325  230 GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPAT 309
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446411886 116 LAGIrATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
Cdd:cd17325  310 LALL-ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
7-413 5.53e-11

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 64.11  E-value: 5.53e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   7 TLVIIVLVYIPVAIdatvLHVAAPTLSMTLGASGnellWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASL 86
Cdd:cd17324    8 AFAIGTTEYVIQGL----LPDIARDFGVSVAQAG----LLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNL 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  87 AAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLI 166
Cdd:cd17324   80 LAALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEK-RGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLA 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 167 NVPIVLVVMGLTARYVPRQAGRRDQPLNLGHAVmliiailllvysaktalkgnlslwaisltlltgtlllglflrtqlat 246
Cdd:cd17324  159 IAVLALLAALLLWRLLPSLPPKKPGSLGLLSSL----------------------------------------------- 191
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 247 srpmidMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRL 326
Cdd:cd17324  192 ------LLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 327 VATGGMALSALsfyGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIeTMAYELGAGLGIAI 406
Cdd:cd17324  266 LLIALLLLAAA---LLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLY-LAAYNLGGALGAAL 341

                 ....*..
gi 446411886 407 FGLLLSR 413
Cdd:cd17324  342 GGLVLDH 348
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
6-183 6.09e-11

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 64.13  E-value: 6.09e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   6 LTLVIIVLVYiPVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
Cdd:cd17320    2 LLLALLVALG-PLAIDMYL--PALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILAS 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  86 LAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFL 165
Cdd:cd17320   79 LLCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLY-SGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFV 157
                        170
                 ....*....|....*...
gi 446411886 166 INVPIVLVVMGLTARYVP 183
Cdd:cd17320  158 FLALLGLLLLLLVLLFLP 175
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
5-184 2.36e-10

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 62.20  E-value: 2.36e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   5 WLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84
Cdd:cd17319    2 WRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLF 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  85 SLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVF 164
Cdd:cd17319   82 TALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWF-PARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
                        170       180
                 ....*....|....*....|
gi 446411886 165 LINVPIVLVVMGLTARYVPR 184
Cdd:cd17319  161 IIEGLLGLLLAVLWWFYLRQ 180
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
23-463 4.90e-10

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 61.87  E-value: 4.90e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  23 TVLHVAAPTLSMTLGASGNELlWIIDIYSLVMAGMVLPMGALGDRIGfKRLLMLGGTLFGLA-SLAAAFSHTASWLIATR 101
Cdd:cd06179   15 TLPAAVLPFIVADLGPSSNST-WISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVVgSIVAGTAKSVNMLIGGQ 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 102 VLLAIGAAMIVPATLAgiratfCEE----KHRNMALGVWAAVGSGGAAFGPLIGGILLEHFY--WGSVFLINVPI-VLVV 174
Cdd:cd06179   93 ALIGIGAGTQGLGAAV------ASElvpnKYRGLVQGVVNLVASPGSALGPLIAGALVEANAagWRWIFYINAIFnALAL 166
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 175 MGLTARYVPRQAGRRDQPLNLGHA--------VMLIIAILLLVY------------SAKTalkgnLSLWAISLTLLTGTL 234
Cdd:cd06179  167 ILLFFFYHPPPRPQLHGSSTRQKLkrldwvglFLLIAGLVLFLLglswggnpypwsSAHV-----IAPLVIGGVLLIAFG 241
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 235 LLGLFLRTQlatsRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPT 314
Cdd:cd06179  242 LYEWKGTKD----GLLPPRLLFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAIL 317
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 315 AGALVSRLG-LRLVATGGMALSALSFYGLAMTDfSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIET 393
Cdd:cd06179  318 AGLLLTKIKhIKWQLVAGFVLFTAFLALLALIT-PDNKALAIAFSVLAGIGIGGPLVLAIVIVQLSVPPEDIGTASGLLG 396
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 394 MAYELGAGLGIAIFGLLLSRSFSASIR-------LPAGLEAQEIAR----ASSSMGEAVQLANSLPPTQGQAILDAARHA 462
Cdd:cd06179  397 SARALGGAVGTAIFTSILSNRLSKNLParvapaaLEAGLPASSLPAllgaLASGNIAALTAVPGINPEIIAAATAALKQA 476

                 .
gi 446411886 463 F 463
Cdd:cd06179  477 Y 477
2_A_01_02 TIGR00880
Multidrug resistance protein;
45-183 5.70e-10

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 57.66  E-value: 5.70e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   45 WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFC 124
Cdd:TIGR00880   2 LLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYP 81
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446411886  125 EEKhRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVP 183
Cdd:TIGR00880  82 PEE-RGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLP 139
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
3-189 1.48e-09

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 59.89  E-value: 1.48e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   3 RQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFG 82
Cdd:COG2807   15 GRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLA 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  83 LASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFceEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGS 162
Cdd:COG2807   95 AGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWF--PDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRG 172
                        170       180
                 ....*....|....*....|....*..
gi 446411886 163 VFLINVPIVLVVMGLTARYVPRQAGRR 189
Cdd:COG2807  173 ALAVWALLALLALLLWLPLLRRRPAAA 199
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
45-418 6.17e-09

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 57.58  E-value: 6.17e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  45 WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIrATFC 124
Cdd:cd17473   39 LLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALI-GDYF 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 125 EEKHRNMALGVWAAVGSGGAAFGPLIGGILLEhFYWGSVFLINVpIVLVVMGLTARYVPRQAGRRDQPLNLGhavmliia 204
Cdd:cd17473  118 EGEERAKMLGLQSAAMSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPG-------- 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 205 illlvySAKTALKGNLSLWAIsltlltgtlllglflrtqlatsrpmidmrlfthriilsgVVMAMTAMITLVGFELLMAQ 284
Cdd:cd17473  188 ------AATAAALPWKRVLPI---------------------------------------YFLAFLAMLLFYVIPIQLPF 222
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 285 ELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATGGMALSALSFYGLAMTDFstqQWQAWGLMALLGFS 364
Cdd:cd17473  223 LLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASG---LWVVLLGAILAGLG 299
                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446411886 365 AASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSFSAS 418
Cdd:cd17473  300 FGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLTGGLS 353
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
30-226 7.46e-09

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 57.60  E-value: 7.46e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  30 PTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAA 109
Cdd:cd17489   20 PLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWG 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 110 MIVPATLAGIrATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFL----INVPIVLVVMGLTARYVPRQ 185
Cdd:cd17489  100 AFTTAAATLV-ADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIvaavLALLALLLVFLVKDPPPVAA 178
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 446411886 186 AGRRDQPLNLGH----AVMLIIAILLLVYSAKTALKGNLSLWAIS 226
Cdd:cd17489  179 EEAEAGTRAFRRlvekKVLPPALILFLASIAYGAISTFLPLYAAE 223
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
11-416 1.03e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 57.05  E-value: 1.03e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  11 IVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAF 90
Cdd:cd06174    1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  91 SHTASWLIATRVLLAIGAAMIVPATLAGIrATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPI 170
Cdd:cd06174   81 APSFWLLLLGRFLLGLGSGLIDPAVLALI-ADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAA 159
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 171 VLVVMGLTARYVPRQAGRRDQPLNLGHAVMLIIAILLLvysaktalkgnlslwaisltlltgtlllglflrtqlatsrpm 250
Cdd:cd06174  160 ALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLK------------------------------------------ 197
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 251 idmRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRL-GLRLVAT 329
Cdd:cd06174  198 ---RVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLiGRKPLLL 274
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 330 GGMALSALsfyGLAMTDFSTQQWQAWGLMALLGFSAASALLASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGL 409
Cdd:cd06174  275 IGLLLMAL---GLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGF 351

                 ....*..
gi 446411886 410 LLSRSFS 416
Cdd:cd06174  352 LLAATFG 358
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
20-175 1.13e-08

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 56.82  E-value: 1.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  20 IDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIA 99
Cdd:cd17365   13 FDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLAL 92
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446411886 100 TRVL--LAIGAAMIVPATLAgirATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVM 175
Cdd:cd17365   93 LRFLtgLGLGAAMPNAITLV---SEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGGVPPLILL 167
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
1-164 2.80e-08

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 55.80  E-value: 2.80e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   1 MFRQWLTLVIIVLVYiPVAIDATVlhVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
Cdd:PRK10473   1 MSRFLLCSFALVLLY-PAGIDMYL--VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAAL 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  81 FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAVGSGGAAFGPLIGGILLEHFYW 160
Cdd:PRK10473  78 FIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRR-RAKVLSLLNGITCIIPVLAPVLGHLIMLKFPW 156

                 ....
gi 446411886 161 GSVF 164
Cdd:PRK10473 157 QSLF 160
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
49-183 6.41e-08

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 54.53  E-value: 6.41e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  49 IYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAamIVPATLAGIrATFCEEKH 128
Cdd:cd17472   40 IYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGSGA--ISSVVMALL-ADLTREEN 116
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446411886 129 RNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVP 183
Cdd:cd17472  117 RTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVP 171
PRK11043 PRK11043
Bcr/CflA family multidrug efflux MFS transporter;
51-201 1.04e-07

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182924 [Multi-domain]  Cd Length: 401  Bit Score: 54.13  E-value: 1.04e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  51 SLVMAGMV---LPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGA--------AMIV---PATL 116
Cdd:PRK11043  48 SLFLAGFAlgqLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRFVQAVGVcsaaviwqALVIdryPAQK 127
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 117 A-GIRATFceekhrnMALgvwaaVGSgGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGRRDQPLNL 195
Cdd:PRK11043 128 AnRVFATI-------MPL-----VAL-SPALAPLLGAWLLNHFGWQAIFATLFAITLLLILPTLRLKPSKKARKQSQDAL 194

                 ....*.
gi 446411886 196 GHAVML 201
Cdd:PRK11043 195 TFKQLL 200
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
49-168 2.59e-07

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 52.58  E-value: 2.59e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  49 IYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMiVPATLAGIRATFCEEKH 128
Cdd:cd17323   42 LFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFFGSS-PLAIGAGTIADLFTPEE 120
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 446411886 129 RNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINV 168
Cdd:cd17323  121 RGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLA 160
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
28-183 3.31e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 52.39  E-value: 3.31e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   28 AAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIG 107
Cdd:TIGR00710  27 AFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFG 106
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446411886  108 AAMIVPATLAGIRATFCEEKHRNM--ALGVWAAVGSggaAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVP 183
Cdd:TIGR00710 107 ASAGSVISQALVRDIYPGEELSRIysILMPVLALAP---AVAPLLGGYILVWLSWHAIFAFLSLAGILLSALIFFILP 181
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
64-180 7.14e-07

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 51.42  E-value: 7.14e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  64 LGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIrATFCEEKHRNMALGVWAAVGSGG 143
Cdd:cd17474  258 LKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLV-TELAPEEERGTASSLYNFVRFLG 336
                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 446411886 144 AAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTAR 180
Cdd:cd17474  337 QAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLAL 373
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
29-369 7.88e-07

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 51.02  E-value: 7.88e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  29 APTLSMTLGASGnellWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGA 108
Cdd:cd17478   23 IAKLGLSYAQAG----LLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGS 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 109 AMIVPATLAGIRATFceEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYVPRQAGR 188
Cdd:cd17478   99 AAFHPEGARLASQAA--GGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKKPE 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 189 RDQPLNLGHAVMLIIAILLLVysaktalkgnLSLWAISltlltgtlllglflrtqlatsrpmidmrlFTHRIILSGVVMA 268
Cdd:cd17478  177 AKKAAAKSSARSTLKGVWRAL----------LLLLIIV-----------------------------FLRSWVLSSLTTF 217
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 269 MTAMITLVGFELLMAQELQFVHglspyeagvfmlpvMVASGFSGPTAGALVSRLGLRLVATGGMALSALSFYGLAMTDFs 348
Cdd:cd17478  218 LPFYLVQRGYSLVFAGLLLSLF--------------LFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPG- 282
                        330       340
                 ....*....|....*....|.
gi 446411886 349 tqqWQAWGLMALLGFSAASAL 369
Cdd:cd17478  283 ---IWSYILLVLAGFLLFASF 300
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
49-182 1.57e-06

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 50.29  E-value: 1.57e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  49 IYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATfCEEKH 128
Cdd:cd17489  235 VYAIALLLSRPFSGKLSDRKGPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDL-VPPHR 313
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446411886 129 RNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
Cdd:cd17489  314 RGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
5-366 3.87e-06

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 49.08  E-value: 3.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   5 WLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84
Cdd:COG0738    7 RRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALG 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  85 SLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGvwAAVGSGGAAFGPLIGGILLehfywgsvf 164
Cdd:COG0738   87 LLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASRLNLL--HAFFSLGALLGPLLGGLLI--------- 155
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 165 linvpivlvvmgltaryvprqAGRRDQPLNLGHAVMLIIAILLLVYSAKTALKGnlslwaisltlltgtlllgLFLRTQL 244
Cdd:COG0738  156 ---------------------LLGLSLSWHLPYLILAVLLLLLALLFLRSKLPE-------------------IEEEEEE 195
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 245 ATSRPMIDMRLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGL 324
Cdd:COG0738  196 AAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP 275
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446411886 325 RLVATGGMALSALSFYGLAmtdFSTQQWQAWGLMALLGFSAA 366
Cdd:COG0738  276 VRLLRLSALLAAVGLLLAL---LAPGPWLALIGLALVGLGLS 314
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
49-177 6.85e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 48.31  E-value: 6.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  49 IYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIrATFCEEKH 128
Cdd:cd17370  242 LFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAV-ADLVPAEL 320
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446411886 129 RNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGL 177
Cdd:cd17370  321 RGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
51-182 9.33e-06

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 47.64  E-value: 9.33e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  51 SLVMAGMVLPM-GALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIgAAMIVPATLAGIrATFCEEKHR 129
Cdd:cd17391   45 TFLVSAIFSPIwGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGV-FSGYVPNATALI-ASQTPKEKS 122
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446411886 130 NMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
Cdd:cd17391  123 GWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFV 175
MFS_OPA_SLC37 cd17312
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ...
4-174 1.16e-05

Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340870 [Multi-domain]  Cd Length: 364  Bit Score: 47.27  E-value: 1.16e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   4 QWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGL 83
Cdd:cd17312    1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  84 ASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSV 163
Cdd:cd17312   81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWF-SKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAA 159
                        170
                 ....*....|.
gi 446411886 164 FLINVPIVLVV 174
Cdd:cd17312  160 FLVPGIVGLVV 170
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
45-166 1.30e-05

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 47.16  E-value: 1.30e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  45 WIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATR-VLLAIGAAMIVPATLAGIRATF 123
Cdd:cd17352   42 WIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLTYgVLGGLGLGLIYSPAIVIVGQYF 121
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 446411886 124 ceEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLI 166
Cdd:cd17352  122 --EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
32-189 1.71e-05

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 46.84  E-value: 1.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  32 LSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMI 111
Cdd:cd17329   26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLF 105
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446411886 112 VPATLAGIrATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYwGSVFLINVPIVLVVMGLTARYVPRQAGRR 189
Cdd:cd17329  106 EPASEAMI-ADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSF-RLLFLAAAVLFLLAALVLLFLLPETRPKR 181
MFS_SLC18A3_VAChT cd17383
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ...
62-156 1.72e-05

Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340941 [Multi-domain]  Cd Length: 378  Bit Score: 46.92  E-value: 1.72e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  62 GALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHRNMALGVWAAVGS 141
Cdd:cd17383   51 GTLIDRVGYDIPMMIGLTVMFLSTAVFAFGESYAVLFFARSLQGVGSAFADTAGLAMIADRFTEEAERSKALGIALAFIS 130
                         90
                 ....*....|....*
gi 446411886 142 GGAAFGPLIGGILLE 156
Cdd:cd17383  131 FGCLVAPPFGGILYE 145
MFS_ShiA_like cd17369
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ...
35-177 3.11e-05

Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340927 [Multi-domain]  Cd Length: 408  Bit Score: 46.37  E-value: 3.11e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  35 TLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAA--AFSHTASWLIatrVLLAIGAAMIV 112
Cdd:cd17369  258 TLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRRPVYLAGALLAALFAFPFfwLLDTGSTWLI---VLAAVVVLGVL 334
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 113 PATLAGIRATFCEE----KHRNMALGVWAAVGSG-GAAFGPLIGGILLEhfYWGSVFLinVPIVLVVMGL 177
Cdd:cd17369  335 HGMMYGPQAAFLAElfptRVRYTGASLGYQLGAIlGGGFAPLIATALVA--ATGSWWP--VALYLAALAV 400
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
25-180 3.65e-05

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 46.06  E-value: 3.65e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  25 LHVAAPTLSM---TLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLF-GLASLAAAFSHTASWLIAT 100
Cdd:cd17490   12 QYVYVPFLSPyaeSLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIA 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 101 RVLLAIGAAMIVPATLagIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTAR 180
Cdd:cd17490   92 RFLSGIAAATWVSFTV--LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLF 169
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
6-183 3.92e-05

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 45.72  E-value: 3.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   6 LTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLAS 85
Cdd:PRK11551  15 LTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFS 94
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  86 LAAAFSHTASWLIATRVL--LAIGAAMivpATLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSV 163
Cdd:PRK11551  95 LATAQAWDFPSLLVARLLtgVGLGGAL---PNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAWRHI 171
                        170       180
                 ....*....|....*....|
gi 446411886 164 FLINVPIVLVVMGLTARYVP 183
Cdd:PRK11551 172 FYVGGVGPLLLVPLLMRWLP 191
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
60-177 4.45e-05

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 45.69  E-value: 4.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  60 PMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAV 139
Cdd:cd17328   53 IFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEK-RTRALGVFYFA 131
                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 446411886 140 GSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGL 177
Cdd:cd17328  132 IPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAI 169
MFS_SLC17A9_like cd17380
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ...
59-166 5.21e-05

Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340938 [Multi-domain]  Cd Length: 361  Bit Score: 45.24  E-value: 5.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  59 LPMGALGDRIGFKRLLMLGGTLFGLASL---AAAFSHTASwLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGV 135
Cdd:cd17380   52 VLGGYLADRFGGKKVLLLAVALWSLATLltpLLAYSSLPL-LILSRILLGLGEGVHFPSMTSLFSRWVPVSE-RSRAVSI 129
                         90       100       110
                 ....*....|....*....|....*....|.
gi 446411886 136 WAAVGSGGAAFGPLIGGILLEHFYWGSVFLI 166
Cdd:cd17380  130 VTAGSYLGTLLGGLIGPLLLEYYGWPSVFYF 160
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
61-173 5.27e-05

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 45.33  E-value: 5.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  61 MGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKhRNMALGVWAAVG 140
Cdd:cd17391  260 LGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLPAINSLLAKITPKEV-AGRIFGYNQSFQ 338
                         90       100       110
                 ....*....|....*....|....*....|...
gi 446411886 141 SGGAAFGPLIGGILLEHFYWGSVFLINVPIVLV 173
Cdd:cd17391  339 YLGNVAGPLLGSAIAAHFGYRAVFVVTALLVLL 371
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
27-179 6.57e-05

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 45.29  E-value: 6.57e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  27 VAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFS-HTASWLIATRVLLA 105
Cdd:cd17353   24 VFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAiSLPLLFLGYGVLGG 103
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446411886 106 IGAAMIVPATLAGIRATFCEekHRNMALG-VWAAVGSGGAAFGPLIgGILLEHFYWGSVFLINVPIVLVVMGLTA 179
Cdd:cd17353  104 IGAGIGYITPVSTAVKWFPD--KRGLATGiVIAGFGLGSLIFSPLI-AYLINTVGVPTTFLILGIIFLIIIVIGA 175
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
8-366 8.84e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 44.51  E-value: 8.84e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   8 LVIIVLVYIPVAIDATVLHVAAPTLSMTLGaSGNELLWIIDIYSLVMAGMV---LPMGALGDRIGFKRLLMLGGTLFGLA 84
Cdd:cd17316    1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFS-LGLSLLQTGLLFAAGFLGRPigaLLFGYLGDRIGRKKALILTLLLFGLA 79
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  85 SLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIrATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFywgsvf 164
Cdd:cd17316   80 TLLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYV-AEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLL------ 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 165 linvpivlvvmgltaryvprqagrrdqPLNLGHAVMLIIAILLLVYSaktalkgnlslwaisltlltgtlllglflrtql 244
Cdd:cd17316  153 ---------------------------SGDWGWRILFLIGALPALLA--------------------------------- 172
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 245 atsrpmidmrLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGL 324
Cdd:cd17316  173 ----------LLLRRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGR 242
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|..
gi 446411886 325 RLVATGGMALSALSFYGLAMTDFSTQQWQAWGLMALLGFSAA 366
Cdd:cd17316  243 KKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGG 284
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
5-158 1.80e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 1.80e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   5 WLTLVIIVLVYIPVAIDATVLhvaAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLA 84
Cdd:COG2211  231 LLLLLAYLLFFLALALVAALL---LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  85 SLAAAFSHTAS--WLIATRVLLAIGAAMIVPATLAGI--RATFCEEKHRN----MALGVWAAVGSGGAAFGPLIGGILLE 156
Cdd:COG2211  308 LLLLFFLGPGNlwLLLVLAALAGIGLGAILVLPWAMLadVVDYDEWKTGRrregLYFGIFTFAIKLGQALAGALAGLLLA 387

                 ..
gi 446411886 157 HF 158
Cdd:COG2211  388 LF 389
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
36-150 6.41e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 42.24  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  36 LGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPAt 115
Cdd:cd17327   36 LKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPG- 114
                         90       100       110
                 ....*....|....*....|....*....|....*
gi 446411886 116 LAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLI 150
Cdd:cd17327  115 FILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLL 149
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
36-182 6.91e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.82  E-value: 6.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  36 LGASGNELLWIIDIYSLV-MAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPa 114
Cdd:cd17490  225 LGASSFQLGLLSIIYLLPnALASLLSGTLFYKKLGERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILFP- 303
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446411886 115 TLAGIRATFCEEKHRNMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMGLTARYV 182
Cdd:cd17490  304 LLMSLSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
61-117 6.94e-04

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 41.78  E-value: 6.94e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  61 MGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIG---AAMIVPATLA 117
Cdd:cd17359   56 AGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAvggASALVPMYIA 115
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
51-416 7.29e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.87  E-value: 7.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  51 SLVMAGMVLPM-GALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFCEEKHR 129
Cdd:cd17355   47 GLLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFATVAAWWFERRR 126
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 130 NMALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLINVPIVLVVMgltaryVPRQAGRRDQPLNLGHAVMLIIAILLLV 209
Cdd:cd17355  127 GLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVL------VPVLLLLRRRPADLALRAYDDASPASPG 200
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 210 YSAKTALKgnlslwaisltlltgtlllglflrtqlatsrpmidMRLFTHRIILSGVVMAMTAMITLVGFELLMAqelqfv 289
Cdd:cd17355  201 STLKEALR-----------------------------------SASFWLLALAFFLCGFAVVGLIVHLVPYLAD------ 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886 290 HGLSPYEAGVFMLPVMVASGFSGPTAGALVSRLGLRLVATGGMALSALSFYGLAMTDFSTQQwqAWGLMALLGFSAASAL 369
Cdd:cd17355  240 RGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLA--LLLFAALFGLGWGATV 317
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*..
gi 446411886 370 LASTSAIMAAAPAEKAAAAGAIETMAYELGAGLGIAIFGLLLSRSFS 416
Cdd:cd17355  318 PLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGS 364
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
67-180 1.21e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.02  E-value: 1.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  67 RIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIrATFCEEKHRNMALGVWAAVGSGGAAF 146
Cdd:cd17330  237 RLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALL-SKSVPSKEQGKAQGIIQSLQSLARII 315
                         90       100       110
                 ....*....|....*....|....*....|....
gi 446411886 147 GPLIGGILLEHFYWGSVFLINVPIVLVVMGLTAR 180
Cdd:cd17330  316 GPLLAGPLYSFLGPGVPFLLAAGLLLIALFLLSL 349
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-145 3.51e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.57  E-value: 3.51e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886   1 MFRQWLTLVIIVLVYIPVAIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTL 80
Cdd:COG2814  203 LLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLL 282
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446411886  81 FGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRNMALGVWAAVGSGGAA 145
Cdd:COG2814  283 LALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELA-PPEARGRASGLYNSAFFLGGP 346
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
51-166 7.28e-03

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 38.76  E-value: 7.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446411886  51 SLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSHTASWLIATRVLLAIGAAMIVPATLAGIRATFcEEKHRN 130
Cdd:cd17475   41 NLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWF-PPRERG 119
                         90       100       110
                 ....*....|....*....|....*....|....*.
gi 446411886 131 MALGVWAAVGSGGAAFGPLIGGILLEHFYWGSVFLI 166
Cdd:cd17475  120 LAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVV 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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