|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09257 |
PRK09257 |
aromatic amino acid transaminase; |
1-397 |
0e+00 |
|
aromatic amino acid transaminase;
Pssm-ID: 181731 Cd Length: 396 Bit Score: 761.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQPhGASLYLPMEGLNSYRHAIA 80
Cdd:PRK09257 1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETE-TTKNYLPIEGLAAYRQAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 81 PLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRF 160
Cdd:PRK09257 80 ELLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 161 NDLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240
Cdd:PRK09257 160 DAMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRIL 320
Cdd:PRK09257 240 VASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409131 321 AMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397
Cdd:PRK09257 320 AMRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| TyrB |
COG1448 |
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ... |
1-397 |
0e+00 |
|
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 441057 Cd Length: 396 Bit Score: 753.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQpHGASLYLPMEGLNSYRHAIA 80
Cdd:COG1448 1 MFEHLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLET-ETTKSYLPIEGDAAFNDAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 81 PLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRF 160
Cdd:COG1448 80 KLLFGADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDATVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 161 NDLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240
Cdd:COG1448 160 DGMLADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGFGDGLEEDAAGLRLFAEAGPEFL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRIL 320
Cdd:COG1448 240 VASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409131 321 AMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397
Cdd:COG1448 320 AMRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
26-393 |
6.40e-91 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 277.65 E-value: 6.40e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 26 SDKVNLSIGLYYNEdgiipQLQAVAEAEARLNAQpHGASLYLPMEGLNSYRHAIAPLLFgaDHPVLKQQRVATIQTLGGS 105
Cdd:pfam00155 1 TDKINLGSNEYLGD-----TLPAVAKAEKDALAG-GTRNLYGPTDGHPELREALAKFLG--RSPVLKLDREAAVVFGSGA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 106 GALKVGADFLKrYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLParsIVLLHPCCHNP 185
Cdd:pfam00155 73 GANIEALIFLL-ANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 186 TGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGmEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVLCEd 265
Cdd:pfam00155 149 TGTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFG-SPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYILGNAA- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 266 aeaagrVLGQLKATVRRNYSSppNFGAQVVAAVLNDEALKASWLaevEEMRTRILAMRQELVKVLStempERNFDYLLNQ 345
Cdd:pfam00155 227 ------VISQLRKLARPFYSS--THLQAAAAAALSDPLLVASEL---EEMRQRIKERRDYLRDGLQ----AAGLSVLPSQ 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 346 RGMFSYTGLSAAQVDR----LREEFGVYLIA--------SGRMCVAGLNTANVQRVAKAF 393
Cdd:pfam00155 292 AGFFLLTGLDPETAKElaqvLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
29-395 |
1.33e-53 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 181.39 E-value: 1.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 29 VNLSIGLYYnedgiIPQLQAVAEAeARLNAQPHGASLYLPMEGLNSYRHAIAPLLFGADHPVLKQQRVatIQTLGGSGAL 108
Cdd:cd00609 1 IDLSIGEPD-----FPPPPEVLEA-LAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEEI--VVTNGAQEAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 109 KVGADFLKRyfPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEatNGVRFNDLLATLKTLPARSIVLLHPCcHNPTGA 188
Cdd:cd00609 73 SLLLRALLN--PGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEE--GGFLLDLELLEAAKTPKTKLLYLNNP-NNPTGA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 189 DLTNDQWDAVIEILKARELIPFLDIAYQGFgaGMEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVlcedaeA 268
Cdd:cd00609 148 VLSEEELEELAELAKKHGILIISDEAYAEL--VYDGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGYLIA------P 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 269 AGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEAlkaswlAEVEEMRTRILAMRQELVKVLSTEMPERNfdyLLNQRGM 348
Cdd:cd00609 220 PEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGE------EHLEELRERYRRRRDALLEALKELGPLVV---VKPSGGF 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446409131 349 FSYTGL----SAAQVDRLREEFGVYLIASG----------RMCVAGLnTANVQRVAKAFAA 395
Cdd:cd00609 291 FLWLDLpegdDEEFLERLLLEAGVVVRPGSafgeggegfvRLSFATP-EEELEEALERLAE 350
|
|
| hisC |
TIGR01141 |
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; ... |
113-283 |
5.19e-04 |
|
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Pssm-ID: 273467 Cd Length: 350 Bit Score: 41.87 E-value: 5.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 113 DFLKRYFPESG--VWVSDPTWENHVAIFAGAGFEVSTYPWYDEatngvrFNDLLATLKTLPARSIVLLHPCC-HNPTGAD 189
Cdd:TIGR01141 86 DLLIRAFLEPGdaVLVPPPTYSMYEISAKIHGAEVVKVPLDED------GQLDLEDILVAIDDKPKLVFLCSpNNPTGNL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 190 LTNDQWDAVIEILKARELIpFLDIAYQGFGAGMEedayairaiaSAGLPA-----LVSNSFSKIFSLYGERVG------- 257
Cdd:TIGR01141 160 FSRGDIEAVLERTPGDALV-VVDEAYGEFSGEPS----------TLPLLAeypnlIVLRTLSKAFGLAGLRIGyaianae 228
|
170 180 190
....*....|....*....|....*....|....*....
gi 446409131 258 ------------GLSVLCED-AEAAGRVLGQLKATVRRN 283
Cdd:TIGR01141 229 iidalnkvrapfNLSRLAQAaAIAALRDDDFIEATVEEI 267
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09257 |
PRK09257 |
aromatic amino acid transaminase; |
1-397 |
0e+00 |
|
aromatic amino acid transaminase;
Pssm-ID: 181731 Cd Length: 396 Bit Score: 761.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQPhGASLYLPMEGLNSYRHAIA 80
Cdd:PRK09257 1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETE-TTKNYLPIEGLAAYRQAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 81 PLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRF 160
Cdd:PRK09257 80 ELLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 161 NDLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240
Cdd:PRK09257 160 DAMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRIL 320
Cdd:PRK09257 240 VASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409131 321 AMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397
Cdd:PRK09257 320 AMRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| TyrB |
COG1448 |
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ... |
1-397 |
0e+00 |
|
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 441057 Cd Length: 396 Bit Score: 753.08 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 1 MFQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQpHGASLYLPMEGLNSYRHAIA 80
Cdd:COG1448 1 MFEHLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLET-ETTKSYLPIEGDAAFNDAVQ 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 81 PLLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRF 160
Cdd:COG1448 80 KLLFGADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDATVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDF 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 161 NDLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGMEEDAYAIRAIASAGLPAL 240
Cdd:COG1448 160 DGMLADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGFGDGLEEDAAGLRLFAEAGPEFL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRIL 320
Cdd:COG1448 240 VASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIK 319
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409131 321 AMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAVM 397
Cdd:COG1448 320 AMRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
|
|
| PTZ00376 |
PTZ00376 |
aspartate aminotransferase; Provisional |
2-396 |
1.37e-167 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 240390 Cd Length: 404 Bit Score: 474.80 E-value: 1.37e-167
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 2 FQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLnAQPHGASLYLPMEGLNSYRHAIAP 81
Cdd:PTZ00376 5 FSQVPLGPPDPILGLAAAFKADPSPSKVNLGIGAYRDENGKPYVLESVRKAEKII-AEKNLDKEYLPIEGLQSFIEAAQK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 82 LLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESG-VWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRF 160
Cdd:PTZ00376 84 LLFGEASYALAEKRIATVQALSGTGALRLGFEFLKRFLPAGTtVYVSNPTWPNHVNIFKSAGLNVKEYRYYDPKTKGLDF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 161 NDLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAG-MEEDAYAIRAIASAGLPA 239
Cdd:PTZ00376 164 DGMLEDLRTAPNGSVVLLHACAHNPTGVDPTEEQWKEIADVMKRKNLIPFFDMAYQGFASGdLDKDAYAIRLFAERGVEF 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 240 LVSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRI 319
Cdd:PTZ00376 244 LVAQSFSKNMGLYGERIGALHIVCANKEEAANVLSQLKLIIRPMYSSPPIHGARIADRILSDPELRAEWLSELKEMSGRI 323
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446409131 320 LAMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAV 396
Cdd:PTZ00376 324 QNMRQLLYDELKALGSPGDWEHIINQIGMFSFTGLTKEQVERLIEKYHIYLLDNGRISVAGLTSKNVDYVAEAIHDV 400
|
|
| PLN02397 |
PLN02397 |
aspartate transaminase |
2-396 |
7.19e-159 |
|
aspartate transaminase
Pssm-ID: 215222 Cd Length: 423 Bit Score: 453.65 E-value: 7.19e-159
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 2 FQKVDAYAGDPILTLMERFKEDPRSDKVNLSIGLYYNEDGIIPQLQAVAEAEARLNAQPHGASlYLPMEGLNSYRHAIAP 81
Cdd:PLN02397 24 FEHVEPAPPDPILGVTEAFLADPSPVKLNLGVGAYRTEEGKPVVLNVVRKAEQRLLAGSRNKE-YLPIEGLAEFNKLSAK 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 82 LLFGADHPVLKQQRVATIQTLGGSGALKVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFN 161
Cdd:PLN02397 103 LAYGADSPAIKENRVATVQCLSGTGSLRLGAEFLARFYPGSTIYIPNPTWGNHHNIFRDAGVPVRTYRYYDPKTRGLDFD 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 162 DLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAG-MEEDAYAIRAIASAGLPAL 240
Cdd:PLN02397 183 GLLEDLKAAPDGSFVLLHACAHNPTGVDPTPEQWEQISDLIKSKNHLPFFDSAYQGFASGdLDADAQSVRMFVEDGHEIL 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 241 VSNSFSKIFSLYGERVGGLSVLCEDAEAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEALKASWLAEVEEMRTRIL 320
Cdd:PLN02397 263 VAQSYAKNMGLYGERVGALSVVCKSADVAVRVKSQLKLIARPMYSNPPIHGASIVATILGDPELFSEWTKELKGMADRII 342
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446409131 321 AMRQELVKVLSTEMPERNFDYLLNQRGMFSYTGLSAAQVDRLREEFGVYLIASGRMCVAGLNTANVQRVAKAFAAV 396
Cdd:PLN02397 343 SMRQKLYDALEARGSPGDWSHITKQIGMFSFTGLNKEQVDRMTKEYHIYMTRDGRISMAGLSSKNVPYLADAIHAV 418
|
|
| Aminotran_1_2 |
pfam00155 |
Aminotransferase class I and II; |
26-393 |
6.40e-91 |
|
Aminotransferase class I and II;
Pssm-ID: 395103 [Multi-domain] Cd Length: 351 Bit Score: 277.65 E-value: 6.40e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 26 SDKVNLSIGLYYNEdgiipQLQAVAEAEARLNAQpHGASLYLPMEGLNSYRHAIAPLLFgaDHPVLKQQRVATIQTLGGS 105
Cdd:pfam00155 1 TDKINLGSNEYLGD-----TLPAVAKAEKDALAG-GTRNLYGPTDGHPELREALAKFLG--RSPVLKLDREAAVVFGSGA 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 106 GALKVGADFLKrYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEATNGVRFNDLLATLKTLParsIVLLHPCCHNP 185
Cdd:pfam00155 73 GANIEALIFLL-ANPGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNP 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 186 TGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGmEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVLCEd 265
Cdd:pfam00155 149 TGTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFG-SPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYILGNAA- 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 266 aeaagrVLGQLKATVRRNYSSppNFGAQVVAAVLNDEALKASWLaevEEMRTRILAMRQELVKVLStempERNFDYLLNQ 345
Cdd:pfam00155 227 ------VISQLRKLARPFYSS--THLQAAAAAALSDPLLVASEL---EEMRQRIKERRDYLRDGLQ----AAGLSVLPSQ 291
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 346 RGMFSYTGLSAAQVDR----LREEFGVYLIA--------SGRMCVAGLNTANVQRVAKAF 393
Cdd:pfam00155 292 AGFFLLTGLDPETAKElaqvLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
|
|
| AAT_like |
cd00609 |
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ... |
29-395 |
1.33e-53 |
|
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.
Pssm-ID: 99734 [Multi-domain] Cd Length: 350 Bit Score: 181.39 E-value: 1.33e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 29 VNLSIGLYYnedgiIPQLQAVAEAeARLNAQPHGASLYLPMEGLNSYRHAIAPLLFGADHPVLKQQRVatIQTLGGSGAL 108
Cdd:cd00609 1 IDLSIGEPD-----FPPPPEVLEA-LAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGGVDVPPEEI--VVTNGAQEAL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 109 KVGADFLKRyfPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYDEatNGVRFNDLLATLKTLPARSIVLLHPCcHNPTGA 188
Cdd:cd00609 73 SLLLRALLN--PGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEE--GGFLLDLELLEAAKTPKTKLLYLNNP-NNPTGA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 189 DLTNDQWDAVIEILKARELIPFLDIAYQGFgaGMEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLSVlcedaeA 268
Cdd:cd00609 148 VLSEEELEELAELAKKHGILIISDEAYAEL--VYDGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGYLIA------P 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 269 AGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDEAlkaswlAEVEEMRTRILAMRQELVKVLSTEMPERNfdyLLNQRGM 348
Cdd:cd00609 220 PEELLERLKKLLPYTTSGPSTLSQAAAAAALDDGE------EHLEELRERYRRRRDALLEALKELGPLVV---VKPSGGF 290
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446409131 349 FSYTGL----SAAQVDRLREEFGVYLIASG----------RMCVAGLnTANVQRVAKAFAA 395
Cdd:cd00609 291 FLWLDLpegdDEEFLERLLLEAGVVVRPGSafgeggegfvRLSFATP-EEELEEALERLAE 350
|
|
| AspB |
COG0436 |
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ... |
1-371 |
2.80e-15 |
|
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis
Pssm-ID: 440205 [Multi-domain] Cd Length: 387 Bit Score: 76.71 E-value: 2.80e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 1 MFQKVDAYAGDPILTLMERFKEDPRSDK--VNLSIGlyyNEDGIIPQ--LQAVAEAearLNAQPHGaslYLPMEGLNSYR 76
Cdd:COG0436 3 LSSRLARLPPSPIREVSALAAELKAAGEdvIDLGIG---EPDFPTPDhiREAAIEA---LDDGVTG---YTPSAGIPELR 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 77 HAIAPLL---FGADhpvLKQQRVatIQTLGGSGALkvgadflkrYF-------PESGVWVSDPTWENHVAIFAGAGFEVS 146
Cdd:COG0436 74 EAIAAYYkrrYGVD---LDPDEI--LVTNGAKEAL---------ALallallnPGDEVLVPDPGYPSYRAAVRLAGGKPV 139
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 147 TYPWYDEATNGVRFNDLLATLkTLPARSIVLLHPccHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFGAGmEEDA 226
Cdd:COG0436 140 PVPLDEENGFLPDPEALEAAI-TPRTKAIVLNSP--NNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYD-GAEH 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 227 YAIRAIASAGLPALVSNSFSKIFSLYGERVGGLsVLCED-AEAAGRVLGQLkatvrrnYSSPPNFgAQVVAAvlndEALK 305
Cdd:COG0436 216 VSILSLPGLKDRTIVINSFSKSYAMTGWRIGYA-VGPPElIAALLKLQSNL-------TSCAPTP-AQYAAA----AALE 282
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446409131 306 ASwLAEVEEMRTRILAMRQELVKVLStempERNFDYLLNQRGMF-----SYTGLSAAQ-VDRLREEFGVYLI 371
Cdd:COG0436 283 GP-QDYVEEMRAEYRRRRDLLVEGLN----EIGLSVVKPEGAFYlfadvPELGLDSEEfAERLLEEAGVAVV 349
|
|
| ARO8 |
COG1167 |
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ... |
46-397 |
2.12e-10 |
|
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis
Pssm-ID: 440781 [Multi-domain] Cd Length: 471 Bit Score: 62.15 E-value: 2.12e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 46 LQAVAEAEARLNAQPHGASL-YLPMEGLNSYRHAIApllfgaDHpvLKQQRVAT-----IQTLGGSGALkvgaDFLKRYF 119
Cdd:COG1167 123 LAALRRALRRALRRLPPALLgYGDPQGLPELREAIA------RY--LARRGVPAspdqiLITSGAQQAL----DLALRAL 190
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 120 PESG--VWVSDPTWENHVAIFAGAGFEVSTYPwYDEatNGVRFNDLLATLKTLPARSIVLLhPCCHNPTGADLTNDQWDA 197
Cdd:COG1167 191 LRPGdtVAVESPTYPGALAALRAAGLRLVPVP-VDE--DGLDLDALEAALRRHRPRAVYVT-PSHQNPTGATMSLERRRA 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 198 VIEILKARE--LIpfldiayqgfgagmEEDAYA--------IRAIASAGLPALV--SNSFSKIFS--LygeRVGGLSvlc 263
Cdd:COG1167 267 LLELARRHGvpII--------------EDDYDSelrydgrpPPPLAALDAPGRViyIGSFSKTLApgL---RLGYLV--- 326
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 264 edaeAAGRVLGQLKATVRRNYSSPPNFGAQVVAAVLNDealkASWLAEVEEMRTRILAMRQELVKVLSTEMPERnFDYLL 343
Cdd:COG1167 327 ----APGRLIERLARLKRATDLGTSPLTQLALAEFLES----GHYDRHLRRLRREYRARRDLLLAALARHLPDG-LRVTG 397
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446409131 344 NQRGMFSY----TGLSAAQV-DRLREEfGVyLIASG-------------RMCVAGLNTANVQRVAKAFAAVM 397
Cdd:COG1167 398 PPGGLHLWlelpEGVDAEALaAAALAR-GI-LVAPGsafsadgpprnglRLGFGAPSEEELEEALRRLAELL 467
|
|
| PRK06836 |
PRK06836 |
pyridoxal phosphate-dependent aminotransferase; |
27-303 |
9.84e-10 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180720 Cd Length: 394 Bit Score: 59.82 E-value: 9.84e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 27 DKV-NLSIGlyyNEDgiIPQLQAVAEAEARLNAQP----HGaslYLPMEGLNSYRHAIAPLL-------FGADHPVLkqq 94
Cdd:PRK06836 33 DNVfDFSLG---NPS--VPPPAAVKEALRELAEEEdpglHG---YMPNAGYPEVREAIAESLnrrfgtpLTADHIVM--- 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 95 rvatiqTLGGSGALKVgadFLKR-------------YFPESGVWVsdptwENHvaifaGAgfeVSTYPWYDEATNGVRFN 161
Cdd:PRK06836 102 ------TCGAAGALNV---ALKAilnpgdevivfapYFVEYRFYV-----DNH-----GG---KLVVVPTDTDTFQPDLD 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 162 DLLA--TLKTlpaRSIVLLHPccHNPTGADLTNDQWDAVIEILKARE--------LI---PFLDIAYQGfgagmEEDAYA 228
Cdd:PRK06836 160 ALEAaiTPKT---KAVIINSP--NNPTGVVYSEETLKALAALLEEKSkeygrpiyLIsdePYREIVYDG-----AEVPYI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 229 IRAIASAglpaLVSNSFSKIFSLYGERVGGLSV--LCEDAEA-------AGRVLGqlkatvrrnYSSPPNFGAQVVAAVL 299
Cdd:PRK06836 230 FKYYDNS----IVVYSFSKSLSLPGERIGYIAVnpEMEDADDlvaalvfANRILG---------FVNAPALMQRVVAKCL 296
|
....
gi 446409131 300 NDEA 303
Cdd:PRK06836 297 DATV 300
|
|
| PRK06225 |
PRK06225 |
pyridoxal phosphate-dependent aminotransferase; |
43-327 |
5.00e-08 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 235749 [Multi-domain] Cd Length: 380 Bit Score: 54.37 E-value: 5.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 43 IPQLQAVAEAEAR-LNAQPHGAslYLPMEGLNSYRHAI-APLLFGADHPVLkqqrvatiqTLGGSGALK-VGADFLKryf 119
Cdd:PRK06225 40 LGPHEEVREAMIRcIEEGEYCK--YPPPEGFPELRELIlKDLGLDDDEALI---------TAGATESLYlVMRAFLS--- 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 120 PESGVWVSDPTW---ENHVAIFAGagfEVSTYPWYDEATNGVRFNDLLATLKTLPARSIVLLHPccHNPTGADLTNDQWD 196
Cdd:PRK06225 106 PGDNAVTPDPGYliiDNFASRFGA---EVIEVPIYSEECNYKLTPELVKENMDENTRLIYLIDP--LNPLGSSYTEEEIK 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 197 AVIEILKARELIPFLDIAYQGFGagmeEDAYAIRAIASAGlpALVSNSFSKIFSLYGERVGGLSvlcedaeAAGRVLGQL 276
Cdd:PRK06225 181 EFAEIARDNDAFLLHDCTYRDFA----REHTLAAEYAPEH--TVTSYSFSKIFGMAGLRIGAVV-------ATPDLIEVV 247
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 446409131 277 KATVRRnyssppNFGAQVVAAVLNDEAL--KASWLAEVEEMRTRILAMRQELV 327
Cdd:PRK06225 248 KSIVIN------DLGTNVIAQEAAIAGLkvKDEWIDRIRRTTFKNQKLIKEAV 294
|
|
| PRK05764 |
PRK05764 |
aspartate aminotransferase; Provisional |
124-335 |
5.41e-07 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 235596 Cd Length: 393 Bit Score: 51.28 E-value: 5.41e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 124 VWVSDPTW---ENHVAIFAGAGFEVSTYPwydeaTNG--VRFNDLLATL--KTlpaRSIVLLHPccHNPTGADLTNDQWD 196
Cdd:PRK05764 118 VIIPAPYWvsyPEMVKLAGGVPVFVPTGE-----ENGfkLTVEQLEAAItpKT---KALILNSP--SNPTGAVYSPEELE 187
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 197 AVIEILKARELIPFLDIAYQGFGAGMEEDAyairAIASAGLP----ALVSNSFSKIFSLYGERVGGLSVLCEDAEAAGRV 272
Cdd:PRK05764 188 AIADVAVEHDIWVLSDEIYEKLVYDGAEFT----SIASLSPElrdrTITVNGFSKAYAMTGWRLGYAAGPKELIKAMSKL 263
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446409131 273 LGQlkatvrrNYSSPPNFgAQvVAAVlndEALKASWlAEVEEMRTRILAMRQELVKVLStEMP 335
Cdd:PRK05764 264 QSH-------STSNPTSI-AQ-YAAV---AALNGPQ-DEVEEMRQAFEERRDLMVDGLN-EIP 312
|
|
| PRK08361 |
PRK08361 |
aspartate aminotransferase; Provisional |
162-378 |
1.02e-06 |
|
aspartate aminotransferase; Provisional
Pssm-ID: 236248 [Multi-domain] Cd Length: 391 Bit Score: 50.26 E-value: 1.02e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 162 DLLATLKTLPARSIVLLHPccHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFgagMEEDAYAIRAIASAGLPALV 241
Cdd:PRK08361 157 DELLELITKRTRMIVINYP--NNPTGATLDKEVAKAIADIAEDYNIYILSDEPYEHF---LYEGAKHYPMIKYAPDNTIL 231
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 242 SNSFSKIFSLYGERVGglsvLCEDAEAAGRVLGQLKATVRRNYSSppnfgaqvVAAVLNDEAL--KASWLAeVEEMRtRI 319
Cdd:PRK08361 232 ANSFSKTFAMTGWRLG----FVIAPEQVIKDMIKLHAYIIGNVAS--------FVQIAGIEALrsKESWKA-VEEMR-KE 297
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446409131 320 LAMRQELVKVLSTEMPERNfdyLLNQRGMFsYTGLSAAQVDRLREEFGVYLIASGRMCV 378
Cdd:PRK08361 298 YNERRKLVLKRLKEMPHIK---VFEPKGAF-YVFANIDETGMSSEDFAEWLLEKARVVV 352
|
|
| AAT_I |
cd01494 |
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ... |
89-221 |
1.85e-06 |
|
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).
Pssm-ID: 99742 [Multi-domain] Cd Length: 170 Bit Score: 47.76 E-value: 1.85e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 89 PVLKQQRVATIQTLGGSGALKVGADFLKRyfPESGVWVSDPTWENHVAIFAG-AGFEVSTYPwYDEATNGVRFNDLLATL 167
Cdd:cd01494 11 RLLQPGNDKAVFVPSGTGANEAALLALLG--PGDEVIVDANGHGSRYWVAAElAGAKPVPVP-VDDAGYGGLDVAILEEL 87
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446409131 168 KTLPARSIVLLHPCCHNPTGADLTndqwDAVIEILKARELIPFLDIAYQGFGAG 221
Cdd:cd01494 88 KAKPNVALIVITPNTTSGGVLVPL----KEIRKIAKEYGILLLVDAASAGGASP 137
|
|
| PRK07337 |
PRK07337 |
pyridoxal phosphate-dependent aminotransferase; |
17-261 |
2.08e-06 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180937 Cd Length: 388 Bit Score: 49.29 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 17 MERFKEDPR-----SDKVNLSIGlyyNEDGIIPQLqaVAEAEARlnAQPHGASLYLPMEGLNSYRHAIAPLL---FGADH 88
Cdd:PRK07337 16 MELAKEAQAleragRDIIHMGIG---EPDFTAPEP--VVEAAAR--ALRRGVTQYTSALGLAPLREAIAAWYarrFGLDV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 89 PvlkQQRVatIQTLGGSGALKVGADFLKryfpESG--VWVSDPTW---ENHVAIFAGAGFEVSTYP-------------- 149
Cdd:PRK07337 89 A---PERI--VVTAGASAALLLACLALV----ERGdeVLMPDPSYpcnRHFVAAAEGRPVLVPSGPaerfqltaadveaa 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 150 WyDEATNGVrfndLLATlktlPArsivllhpcchNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGfgagMEEDAYAI 229
Cdd:PRK07337 160 W-GERTRGV----LLAS----PS-----------NPTGTSIAPDELRRIVEAVRARGGFTIVDEIYQG----LSYDAAPV 215
|
250 260 270
....*....|....*....|....*....|..
gi 446409131 230 RAIAsAGLPALVSNSFSKIFSLYGERVGGLSV 261
Cdd:PRK07337 216 SALS-LGDDVITINSFSKYFNMTGWRLGWLVV 246
|
|
| HisC |
COG0079 |
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ... |
120-331 |
3.60e-06 |
|
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis
Pssm-ID: 439849 [Multi-domain] Cd Length: 341 Bit Score: 48.59 E-value: 3.60e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 120 PESGVWVSDPTWENHVAIFAGAGFEVSTYPwyDEATNGVRFNDLLATLKTlPARSIVLLHPccHNPTGADLTNDQWDAVI 199
Cdd:COG0079 88 PGDEVLVPEPTFSEYPIAARAAGAEVVEVP--LDEDFSLDLDALLAAITE-RTDLVFLCNP--NNPTGTLLPREELEALL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 200 EILKARELIpFLDIAYQGFGagmEEDAYAIRAIAS-AGLpaLVSNSFSKIFSLYGERVG-GLsvlcedaeAAGRVLGQLK 277
Cdd:COG0079 163 EALPADGLV-VVDEAYAEFV---PEEDSALPLLARyPNL--VVLRTFSKAYGLAGLRLGyAI--------ASPELIAALR 228
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 446409131 278 AtVRRNY--SSPpnfgAQVVA-AVLNDEalkaswlAEVEEMRTRILAMRQELVKVLS 331
Cdd:COG0079 229 R-VRGPWnvNSL----AQAAAlAALEDR-------AYLEETRARLRAERERLAAALR 273
|
|
| PRK08960 |
PRK08960 |
pyridoxal phosphate-dependent aminotransferase; |
49-259 |
4.40e-05 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 181595 Cd Length: 387 Bit Score: 45.05 E-value: 4.40e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 49 VAEAEARLNAqphGASLYLPMEGLNSYRHAIAPLL---FGADhpvLKQQRVatIQTLGGSGALKVGADFLKRyfPESGVW 125
Cdd:PRK08960 51 VAAGQAALAA---GHTRYTAARGLPALREAIAGFYaqrYGVD---VDPERI--LVTPGGSGALLLASSLLVD--PGKHWL 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 126 VSDPTW---ENHVAIFAGAGFEVSTYPwydeatnGVRFN---DLLATLKTlpARSIVLLHPCCHNPTGADLTNDQWDAVI 199
Cdd:PRK08960 121 LADPGYpcnRHFLRLVEGAAQLVPVGP-------DSRYQltpALVERHWN--ADTVGALVASPANPTGTLLSRDELAALS 191
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 200 EILKARELIPFLDIAYQGFGAGMeeDAYAIRAIASAglpALVSNSFSKIFSLYGERVGGL 259
Cdd:PRK08960 192 QALRARGGHLVVDEIYHGLTYGV--DAASVLEVDDD---AFVLNSFSKYFGMTGWRLGWL 246
|
|
| PRK05166 |
PRK05166 |
histidinol-phosphate transaminase; |
162-322 |
6.67e-05 |
|
histidinol-phosphate transaminase;
Pssm-ID: 179950 Cd Length: 371 Bit Score: 44.74 E-value: 6.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 162 DLLATLKTLPARSIVLLHPCCHNPTGADLTNDQWDAVIEILKARELIpFLDIAYQGFGAGmeeDAYAIRA--IASAGLPA 239
Cdd:PRK05166 148 DLDALCAAVARAPRMLMFSNPSNPVGSWLTADQLARVLDATPPETLI-VVDEAYAEYAAG---DDYPSALtlLKARGLPW 223
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 240 LVSNSFSKIFSLYGERVG-GLSvlcEDAEaagrvLGQLKATVRRNYSSppNFGAQVVA-AVLNDEALKAS----WLAEVE 313
Cdd:PRK05166 224 IVLRTFSKAYGLAGLRVGyGLV---SDPE-----LVGLLDRVRTPFNV--NGAAQAAAlAALDDEEHLAKgvalALAERE 293
|
....*....
gi 446409131 314 EMRTRILAM 322
Cdd:PRK05166 294 RLKKELAEM 302
|
|
| PRK06108 |
PRK06108 |
pyridoxal phosphate-dependent aminotransferase; |
62-329 |
1.64e-04 |
|
pyridoxal phosphate-dependent aminotransferase;
Pssm-ID: 180404 Cd Length: 382 Bit Score: 43.39 E-value: 1.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 62 GASLYLPMEGLNSYRHAIAPL---LFGADHPVlkqQRVATiqTLGGSGALKVGADFLKRyfPESGVWVSDPTWENHVAIF 138
Cdd:PRK06108 53 GETFYTHNLGIPELREALARYvsrLHGVATPP---ERIAV--TSSGVQALMLAAQALVG--PGDEVVAVTPLWPNLVAAP 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 139 AGAGFEVSTYPW-YDEATNGVRFNDLLATLkTLPARSIVLLHPccHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQG 217
Cdd:PRK06108 126 KILGARVVCVPLdFGGGGWTLDLDRLLAAI-TPRTRALFINSP--NNPTGWTASRDDLRAILAHCRRHGLWIVADEVYER 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 218 FGAGMEEDAYAIRAIASAGLPALVSNSFSKIFSLYGERVGGLsvlcEDAEAAGRVLGQLkatVRRNYSSPPNF---GAqv 294
Cdd:PRK06108 203 LYYAPGGRAPSFLDIAEPDDRIIFVNSFSKNWAMTGWRLGWL----VAPPALGQVLEKL---IEYNTSCVAQFvqrAA-- 273
|
250 260 270
....*....|....*....|....*....|....*
gi 446409131 295 VAAVLNDEALKASWLAEVEEMRTRILAMRQELVKV 329
Cdd:PRK06108 274 VAALDEGEDFVAELVARLRRSRDHLVDALRALPGV 308
|
|
| PRK07777 |
PRK07777 |
putative succinyldiaminopimelate transaminase DapC; |
25-331 |
2.42e-04 |
|
putative succinyldiaminopimelate transaminase DapC;
Pssm-ID: 236095 [Multi-domain] Cd Length: 387 Bit Score: 42.72 E-value: 2.42e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 25 RSDKVNLSIGlYYNEDGIIPQLQAVAEAEArlnaqpHGASLYLPMEGLNSYRHAIAP-------LLFGADHPVLKqqrva 97
Cdd:PRK07777 23 RTGAVNLGQG-FPDEDGPPEMLEAAQEAIA------GGVNQYPPGPGIPELRAAIAAqrrrrygLEYDPDTEVLV----- 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 98 tiqTLGGSGAlkVGADFLKRYFPESGVWVSDPTWENHVAIFAGAGFEVSTYPWYdEATNGVRFN-DLLATLKTLPARSIV 176
Cdd:PRK07777 91 ---TVGATEA--IAAAVLGLVEPGDEVLLIEPYYDSYAAVIAMAGAHRVPVPLV-PDGRGFALDlDALRAAVTPRTRALI 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 177 LLHPccHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFgagMEEDAyaiRAIASAGLPAL------VSnSFSKIFS 250
Cdd:PRK07777 165 VNSP--HNPTGTVLTAAELAAIAELAVEHDLLVITDEVYEHL---VFDGA---RHLPLATLPGMrertvtIS-SAAKTFN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 251 LYGERVGGlsvLCEDAEaagrvlgqLKATVRR-----NYSSPPNFGAQVVAAVLNDEAlkasWlaeVEEMRTRILAMRQE 325
Cdd:PRK07777 236 VTGWKIGW---ACGPAP--------LIAAVRAakqylTYVGGAPFQPAVAHALDHEDA----W---VAALRDSLQAKRDR 297
|
....*.
gi 446409131 326 LVKVLS 331
Cdd:PRK07777 298 LAAGLA 303
|
|
| hisC |
TIGR01141 |
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; ... |
113-283 |
5.19e-04 |
|
histidinol-phosphate aminotransferase; Alternate names: histidinol-phosphate transaminase; imidazole acetol-phosphate transaminase Histidinol-phosphate aminotransferase is a pyridoxal-phosphate dependent enzyme. [Amino acid biosynthesis, Histidine family]
Pssm-ID: 273467 Cd Length: 350 Bit Score: 41.87 E-value: 5.19e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 113 DFLKRYFPESG--VWVSDPTWENHVAIFAGAGFEVSTYPWYDEatngvrFNDLLATLKTLPARSIVLLHPCC-HNPTGAD 189
Cdd:TIGR01141 86 DLLIRAFLEPGdaVLVPPPTYSMYEISAKIHGAEVVKVPLDED------GQLDLEDILVAIDDKPKLVFLCSpNNPTGNL 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 190 LTNDQWDAVIEILKARELIpFLDIAYQGFGAGMEedayairaiaSAGLPA-----LVSNSFSKIFSLYGERVG------- 257
Cdd:TIGR01141 160 FSRGDIEAVLERTPGDALV-VVDEAYGEFSGEPS----------TLPLLAeypnlIVLRTLSKAFGLAGLRIGyaianae 228
|
170 180 190
....*....|....*....|....*....|....*....
gi 446409131 258 ------------GLSVLCED-AEAAGRVLGQLKATVRRN 283
Cdd:TIGR01141 229 iidalnkvrapfNLSRLAQAaAIAALRDDDFIEATVEEI 267
|
|
| PRK07681 |
PRK07681 |
LL-diaminopimelate aminotransferase; |
126-278 |
1.09e-03 |
|
LL-diaminopimelate aminotransferase;
Pssm-ID: 181081 Cd Length: 399 Bit Score: 40.94 E-value: 1.09e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 126 VSDPTWENHVAIFAGAGFEVSTYPWYDEatngvrfNDLLATLKTLP------ARSIVLLHPccHNPTGADLTNDQWDAVI 199
Cdd:PRK07681 122 VPDPGYTAYETGIQMAGATSYYMPLKKE-------NDFLPDLELIPeeiadkAKMMILNFP--GNPVPAMAHEDFFKEVI 192
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446409131 200 EILKARELIPFLDIAYQGFGAGMEEdAYAIRAIASAGLPALVSNSFSKIFSLYGERVGglsVLCEDAEAAgRVLGQLKA 278
Cdd:PRK07681 193 AFAKKHNIIVVHDFAYAEFYFDGNK-PISFLSVPGAKEVGVEINSLSKSYSLAGSRIG---YMIGNEEIV-RALTQFKS 266
|
|
| PRK07683 |
PRK07683 |
aminotransferase A; Validated |
152-257 |
2.39e-03 |
|
aminotransferase A; Validated
Pssm-ID: 236075 Cd Length: 387 Bit Score: 39.71 E-value: 2.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 152 DEATNGVRFN-DLLATLKTLPARSIVLLHPCchNPTGADLTNDQWDAVIEILKARELIPFLDIAYQgfgagmeEDAYAIR 230
Cdd:PRK07683 141 DTRSTGFRLTaEALENAITEKTRCVVLPYPS--NPTGVTLSKEELQDIADVLKDKNIFVLSDEIYS-------ELVYEQP 211
|
90 100 110
....*....|....*....|....*....|..
gi 446409131 231 AIASAGLPAL-----VSNSFSKIFSLYGERVG 257
Cdd:PRK07683 212 HTSIAHFPEMrektiVINGLSKSHSMTGWRIG 243
|
|
| PRK07324 |
PRK07324 |
transaminase; Validated |
70-257 |
3.50e-03 |
|
transaminase; Validated
Pssm-ID: 235989 Cd Length: 373 Bit Score: 39.15 E-value: 3.50e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 70 EGLNSYRHAIAPLLfgadhpvlkqQRVATIQTLGGSGAlkVGADFLKRYF---PESGVWVSDPTWENHVAIFAGAGFEVS 146
Cdd:PRK07324 62 EGSPEFKEAVASLY----------QNVKPENILQTNGA--TGANFLVLYAlvePGDHVISVYPTYQQLYDIPESLGAEVD 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446409131 147 TYPWYDEATNGVRFNDL--LATLKTlpaRSIVLLHPccHNPTGADLTNDQWDAVIEILKARELIPFLDIAYQGFgagMEE 224
Cdd:PRK07324 130 YWQLKEENGWLPDLDELrrLVRPNT---KLICINNA--NNPTGALMDRAYLEEIVEIARSVDAYVLSDEVYRPL---DED 201
|
170 180 190
....*....|....*....|....*....|...
gi 446409131 225 DAYAirAIASAGLPALVSNSFSKIFSLYGERVG 257
Cdd:PRK07324 202 GSTP--SIADLYEKGISTNSMSKTYSLPGIRVG 232
|
|
| |
