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Conserved domains on  [gi|446396087|ref|WP_000473942|]
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MULTISPECIES: exotoxin beta-grasp domain-containing protein [Staphylococcus]

Protein Classification

superantigen-like protein SSL4( domain architecture ID 1002838)

superantigen-like protein SSL4 is a secreted protein that plays a role in immune innate response inhibition by interfering with host TLR2-mediated pathway

CATH:  2.40.50.110|3.10.20.120

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK13042 super family cl32851
superantigen-like protein SSL4; Reviewed;
120-193 2.29e-09

superantigen-like protein SSL4; Reviewed;


The actual alignment was detected with superfamily member PRK13042:

Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 55.79  E-value: 2.29e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446396087 120 LNKEVVTLKELDHIIRFAHI-SYGLYmgEHLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13042 218 ITKEQISLKELDFKLRKQLIeKHNLY--GNVGSGKIVIKMKNGGKYTFELHKKLQENRMADVIDGTNIDNIEVNI 290
 
Name Accession Description Interval E-value
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
120-193 2.29e-09

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 55.79  E-value: 2.29e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446396087 120 LNKEVVTLKELDHIIRFAHI-SYGLYmgEHLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13042 218 ITKEQISLKELDFKLRKQLIeKHNLY--GNVGSGKIVIKMKNGGKYTFELHKKLQENRMADVIDGTNIDNIEVNI 290
 
Name Accession Description Interval E-value
PRK13042 PRK13042
superantigen-like protein SSL4; Reviewed;
120-193 2.29e-09

superantigen-like protein SSL4; Reviewed;


Pssm-ID: 183854 [Multi-domain]  Cd Length: 291  Bit Score: 55.79  E-value: 2.29e-09
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446396087 120 LNKEVVTLKELDHIIRFAHI-SYGLYmgEHLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13042 218 ITKEQISLKELDFKLRKQLIeKHNLY--GNVGSGKIVIKMKNGGKYTFELHKKLQENRMADVIDGTNIDNIEVNI 290
PRK13041 PRK13041
superantigen-like protein SSL2; Reviewed;
69-196 2.02e-08

superantigen-like protein SSL2; Reviewed;


Pssm-ID: 106078  Cd Length: 231  Bit Score: 52.33  E-value: 2.02e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446396087  69 RYSQNTINGKSNKSRNWVYSERPLNENQVrinleGTYrvaDRVYTPkrnITLNKEVVTLKELDHIIRFAHI-SYGLYmGE 147
Cdd:PRK13041 116 KYSIGGITSANDKAVDLIAEARVIKADHI-----GEY---DYDFFP---FKIDKEAMSLKEIDFKLRKYLIdNYGLY-GE 183

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 446396087 148 hLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKLVKS 196
Cdd:PRK13041 184 -MSTGKITVKKKYYGKYTFELDKKLQEDRMSDVINVTDIDRIEIKVRKA 231
PRK13335 PRK13335
superantigen-like protein SSL3; Reviewed;
120-193 1.09e-07

superantigen-like protein SSL3; Reviewed;


Pssm-ID: 139494 [Multi-domain]  Cd Length: 356  Bit Score: 50.90  E-value: 1.09e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446396087 120 LNKEVVTLKELDHIIRFAHIS-YGLYmgEHLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13335 283 ITKEEISLKELDFKLRKQLIEkHNLY--GNMGSGTIVIKMKNGGKYTFELHKKLQEHRMADVIDGTNIDKIEVNI 355
PRK13346 PRK13346
superantigen-like protein SSL7; Reviewed;
117-193 2.60e-06

superantigen-like protein SSL7; Reviewed;


Pssm-ID: 106304 [Multi-domain]  Cd Length: 231  Bit Score: 46.54  E-value: 2.60e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446396087 117 NITLNKEVVTLKELDHIIRFAHI-SYGLYMGEHlPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13346 152 SFLINKEEVSLKELDFKIRQQLVeNYGLYKGTT-KYGKITINLKDEKKEEIDLGDKLQFERMGDVLNSKDIQNIAVTI 228
PRK13036 PRK13036
superantigen-like protein SSL11; Reviewed;
119-193 1.16e-04

superantigen-like protein SSL11; Reviewed;


Pssm-ID: 171852  Cd Length: 227  Bit Score: 41.47  E-value: 1.16e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446396087 119 TLNKEVVTLKELDHIIRFAHI-SYGLYMGEhlPK-GNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13036 153 SINKEEISLKELDFKLRKHLIdKHDLYKTE--PKdSKIRITMKNGGYYTFELNKKLQPHRMGDTIDSRNIEKIEVNL 227
PRK13039 PRK13039
superantigen-like protein SSL8; Reviewed;
120-193 2.52e-04

superantigen-like protein SSL8; Reviewed;


Pssm-ID: 171854  Cd Length: 232  Bit Score: 40.45  E-value: 2.52e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446396087 120 LNKEVVTLKELDHIIRFAHIS-YGLYMGEhLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13039 158 IQKEEVSLKELDFKIRKLLIKkYKLYEGS-ADKGRIVINMKDENKYEIDLSDKLDFERMADVINSEQIKNIEVNL 231
PRK13037 PRK13037
superantigen-like protein SSL1; Reviewed;
122-189 8.84e-04

superantigen-like protein SSL1; Reviewed;


Pssm-ID: 106074  Cd Length: 226  Bit Score: 38.80  E-value: 8.84e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446396087 122 KEVVTLKELDHIIRFAHIS-YGLYmGEHLPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNV 189
Cdd:PRK13037 154 KEDISLKELDYRLRERAIKqHGLY-SNGLKQGQITITMKDGKSHTIDLSQKLEKERMGESIDGRQIQKI 221
PRK13350 PRK13350
superantigen-like protein SSL12; Reviewed;
121-189 2.74e-03

superantigen-like protein SSL12; Reviewed;


Pssm-ID: 171995 [Multi-domain]  Cd Length: 238  Bit Score: 37.64  E-value: 2.74e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446396087 121 NKEVVTLKELDHIIRFAHISYGLYMGEHLPKGNIVINTKdGGKYTLESHKELQKDRENVKINTADIKNV 189
Cdd:PRK13350 166 NKPVLTLKEIDFRAREALIKNKILYNENRNKGKLKITGG-GNNYTIDLSKRLHSDLANVYVKNPNKITV 233
PRK13345 PRK13345
superantigen-like protein SSL9; Reviewed;
120-193 3.15e-03

superantigen-like protein SSL9; Reviewed;


Pssm-ID: 106303  Cd Length: 232  Bit Score: 37.29  E-value: 3.15e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446396087 120 LNKEVVTLKELDHIIRFAHIS-YGLYMGEHlPKGNIVINTKDGGKYTLESHKELQKDRENVKINTADIKNVTFKL 193
Cdd:PRK13345 158 IQKEEVSLKELDFKIRKMLVEkYRLYKGAS-DKGRIVINMKDEKKYVIDLSEKLSFDRMFDVMDSKQIKNIEVNL 231
PRK13035 PRK13035
superantigen-like protein SSL5; Reviewed;
107-189 4.77e-03

superantigen-like protein SSL5; Reviewed;


Pssm-ID: 171851  Cd Length: 234  Bit Score: 36.96  E-value: 4.77e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446396087 107 VADRVYTPKRNITLNKEVVTLKELDHIIRFAHI-SYGLYmgEHLPKGN-IVINTKDGGKYTLESHKELQKDRENVKINTA 184
Cdd:PRK13035 147 EGDGIATYGRVHYIYKEEISLKELDFKLRQYLIqNFDLY--KKFPKDSkIKVIMKDGGYYTFELNKKLQTNRMSDVIDGR 224


                 ....*
gi 446396087 185 DIKNV 189
Cdd:PRK13035 225 NIEKI 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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