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Conserved domains on  [gi|446384850|ref|WP_000462705|]
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aspartate transaminase [Salmonella enterica]

Protein Classification

amino acid aminotransferase( domain architecture ID 10013160)

pyridoxal-5'-phosphate (PLP)-dependent amino acid aminotransferase such as tyrosine transaminase, aspartate transaminase, and aromatic-amino-acid aminotransferase

CATH:  3.90.1150.10|3.40.640.10
EC:  2.6.1.-
Gene Ontology:  GO:0030170|GO:0008483
PubMed:  8112347|10800595|10673430|11933250
SCOP:  4000670

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK09257 PRK09257
aromatic amino acid transaminase;
1-396 0e+00

aromatic amino acid transaminase;


:

Pssm-ID: 181731  Cd Length: 396  Bit Score: 794.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   1 MFENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQE 80
Cdd:PRK09257   1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETETTKNYLPIEGLAAYRQAVQE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  81 LLFGKGSALINDKRARTAQTPGGTGALRIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFE 160
Cdd:PRK09257  81 LLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDFD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 161 ALQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAALHKELIV 240
Cdd:PRK09257 161 AMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 241 ASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQR 320
Cdd:PRK09257 241 ASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIKA 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446384850 321 MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAVL 396
Cdd:PRK09257 321 MRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
 
Name Accession Description Interval E-value
PRK09257 PRK09257
aromatic amino acid transaminase;
1-396 0e+00

aromatic amino acid transaminase;


Pssm-ID: 181731  Cd Length: 396  Bit Score: 794.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   1 MFENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQE 80
Cdd:PRK09257   1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETETTKNYLPIEGLAAYRQAVQE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  81 LLFGKGSALINDKRARTAQTPGGTGALRIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFE 160
Cdd:PRK09257  81 LLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDFD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 161 ALQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAALHKELIV 240
Cdd:PRK09257 161 AMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 241 ASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQR 320
Cdd:PRK09257 241 ASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIKA 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446384850 321 MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAVL 396
Cdd:PRK09257 321 MRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
TyrB COG1448
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ...
 1-396 0e+00

Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 441057  Cd Length: 396  Bit Score: 775.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   1 MFENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQE 80
Cdd:COG1448    1 MFEHLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLETETTKSYLPIEGDAAFNDAVQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  81 LLFGKGSALINDKRARTAQTPGGTGALRIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFE 160
Cdd:COG1448   81 LLFGADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDATVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDFD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 161 ALQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAALHKELIV 240
Cdd:COG1448  161 GMLADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGFGDGLEEDAAGLRLFAEAGPEFLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 241 ASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQR 320
Cdd:COG1448  241 ASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIKA 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446384850 321 MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAVL 396
Cdd:COG1448  321 MRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
26-392 9.36e-106

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 315.78  E-value: 9.36e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   26 PGKINLGIGVYKDETgktpvLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQELLFGkgSALINDKRARTAQTPGGTG 105
Cdd:pfam00155   1 TDKINLGSNEYLGDT-----LPAVAKAEKDALAGGTRNLYGPTDGHPELREALAKFLGR--SPVLKLDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  106 ALRIAADFLAKNtPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFEALQASLSEAQagdVVLFHGCCHNPT 185
Cdd:pfam00155  74 ANIEALIFLLAN-PGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNPT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  186 GIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGlEEDAEGLRAFAALHKELIVASSYSKNFGLYNERVGACTlvaada 265
Cdd:pfam00155 150 GTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFG-SPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYIL------ 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  266 eTVDRAFSQMKSAIRANYSnpPAHGASIVATILSNDALCAiweQELTDMRQRIQRMRQLFVNTLQEKGanrdFSFIIKQN 345
Cdd:pfam00155 223 -GNAAVISQLRKLARPFYS--STHLQAAAAAALSDPLLVA---SELEEMRQRIKERRDYLRDGLQAAG----LSVLPSQA 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446384850  346 GMFSFSGLTKDQVLR----LREEFGIYAVA--------SGRVNVAGMTPDNMAPLCEAI 392
Cdd:pfam00155 293 GFFLLTGLDPETAKElaqvLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 29-392 1.74e-52

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 178.30  E-value: 1.74e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  29 INLGIGVYKDETGKtpvltSVKKAEQYLLENETTKNYLGIDGIPEFARCTQELLFGKGSalINDKRARTAQTPGGTGALR 108
Cdd:cd00609    1 IDLSIGEPDFPPPP-----EVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGG--VDVPPEEIVVTNGAQEALS 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 109 IAADFLAKntPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFEALQASLSEAqaGDVVLFHgCCHNPTGID 188
Cdd:cd00609   74 LLLRALLN--PGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEGGFLLDLELLEAAKTPK--TKLLYLN-NPNNPTGAV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 189 PTLEQWQALAELSVEKGWLPLFDFAYQGFARglEEDAEGLRAFAALHKELIVASSYSKNFGLYNERVGActLVAADAEtv 268
Cdd:cd00609  149 LSEEELEELAELAKKHGILIISDEAYAELVY--DGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGY--LIAPPEE-- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 269 drAFSQMKSAIRANYSNPPAHGASIVATILSNDalcaiwEQELTDMRQRIQRMRQLFVNTLQEKGanrDFSFIIKQNGMF 348
Cdd:cd00609  223 --LLERLKKLLPYTTSGPSTLSQAAAAAALDDG------EEHLEELRERYRRRRDALLEALKELG---PLVVVKPSGGFF 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446384850 349 SF----SGLTKDQVLRLREEFGIYAVASG----------RVNVAGmTPDNMAPLCEAI 392
Cdd:cd00609  292 LWldlpEGDDEEFLERLLLEAGVVVRPGSafgeggegfvRLSFAT-PEEELEEALERL 348
 
Name Accession Description Interval E-value
PRK09257 PRK09257
aromatic amino acid transaminase;
1-396 0e+00

aromatic amino acid transaminase;


Pssm-ID: 181731  Cd Length: 396  Bit Score: 794.33  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   1 MFENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQE 80
Cdd:PRK09257   1 MFEHLEAAPADPILGLMEAFRADPRPDKVNLGVGVYKDEQGRTPVLRAVKKAEARLLETETTKNYLPIEGLAAYRQAVQE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  81 LLFGKGSALINDKRARTAQTPGGTGALRIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFE 160
Cdd:PRK09257  81 LLFGADSPALAAGRVATVQTPGGTGALRVGADFLKRAFPDAKVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAATKGLDFD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 161 ALQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAALHKELIV 240
Cdd:PRK09257 161 AMLADLSQAPAGDVVLLHGCCHNPTGADLTPEQWDELAELLKERGLIPFLDIAYQGFGDGLEEDAYGLRAFAAAGLELLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 241 ASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQR 320
Cdd:PRK09257 241 ASSFSKNFGLYGERVGALSVVAEDAEEADRVLSQLKATIRTNYSNPPAHGAAIVATILNDPELRAEWEAELEEMRERIKA 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446384850 321 MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAVL 396
Cdd:PRK09257 321 MRQLLVEALKAKGPSRDFDFIARQRGMFSYSGLTPEQVDRLREEFGVYAVGSGRINVAGLNESNIDYVAEAIAAVL 396
TyrB COG1448
Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic ...
 1-396 0e+00

Aspartate/aromatic aminotransferase [Amino acid transport and metabolism]; Aspartate/aromatic aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 441057  Cd Length: 396  Bit Score: 775.43  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   1 MFENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQE 80
Cdd:COG1448    1 MFEHLEAAPGDPILGLMEAFRADPRPNKVNLGVGVYKDEQGRTPVLRAVKAAEQRLLETETTKSYLPIEGDAAFNDAVQK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  81 LLFGKGSALINDKRARTAQTPGGTGALRIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFE 160
Cdd:COG1448   81 LLFGADSPAVAAGRVATVQTPGGTGALRVGADFLKRAFPDATVWVSDPTWPNHRAIFEAAGLEVKTYPYYDAETGGVDFD 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 161 ALQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGLEEDAEGLRAFAALHKELIV 240
Cdd:COG1448  161 GMLADLKQLPAGDVVLLHGCCHNPTGADLTPEQWQEVAELLKERGLIPFLDIAYQGFGDGLEEDAAGLRLFAEAGPEFLV 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 241 ASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQR 320
Cdd:COG1448  241 ASSFSKNFGLYRERVGALSVVAADAEEADRVLSQLKALIRTNYSNPPDHGAAIVATILNDPELRALWEAELAEMRERIKA 320

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446384850 321 MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAVL 396
Cdd:COG1448  321 MRQQLVDALRAKGPSRDFSFIARQRGMFSYLGLSPEQVDRLREEFGIYMVGSGRINVAGLNESNIDYVAEAIAAVL 396
PTZ00376 PTZ00376
aspartate aminotransferase; Provisional
 2-396 1.27e-178

aspartate aminotransferase; Provisional


Pssm-ID: 240390  Cd Length: 404  Bit Score: 502.92  E-value: 1.27e-178
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   2 FENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQEL 81
Cdd:PTZ00376   5 FSQVPLGPPDPILGLAAAFKADPSPSKVNLGIGAYRDENGKPYVLESVRKAEKIIAEKNLDKEYLPIEGLQSFIEAAQKL 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  82 LFGKGSALINDKRARTAQTPGGTGALRIAADFLAK-NTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFE 160
Cdd:PTZ00376  85 LFGEASYALAEKRIATVQALSGTGALRLGFEFLKRfLPAGTTVYVSNPTWPNHVNIFKSAGLNVKEYRYYDPKTKGLDFD 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 161 ALQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARG-LEEDAEGLRAFAALHKELI 239
Cdd:PTZ00376 165 GMLEDLRTAPNGSVVLLHACAHNPTGVDPTEEQWKEIADVMKRKNLIPFFDMAYQGFASGdLDKDAYAIRLFAERGVEFL 244

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 240 VASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQ 319
Cdd:PTZ00376 245 VAQSFSKNMGLYGERIGALHIVCANKEEAANVLSQLKLIIRPMYSSPPIHGARIADRILSDPELRAEWLSELKEMSGRIQ 324

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446384850 320 RMRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAVL 396
Cdd:PTZ00376 325 NMRQLLYDELKALGSPGDWEHIINQIGMFSFTGLTKEQVERLIEKYHIYLLDNGRISVAGLTSKNVDYVAEAIHDVV 401
PLN02397 PLN02397
aspartate transaminase
 2-395 2.87e-174

aspartate transaminase


Pssm-ID: 215222  Cd Length: 423  Bit Score: 492.55  E-value: 2.87e-174
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   2 FENITAAPADPILGLTDLFRADDRPGKINLGIGVYKDETGKTPVLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQEL 81
Cdd:PLN02397  24 FEHVEPAPPDPILGVTEAFLADPSPVKLNLGVGAYRTEEGKPVVLNVVRKAEQRLLAGSRNKEYLPIEGLAEFNKLSAKL 103

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  82 LFGKGSALINDKRARTAQTPGGTGALRIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFEA 161
Cdd:PLN02397 104 AYGADSPAIKENRVATVQCLSGTGSLRLGAEFLARFYPGSTIYIPNPTWGNHHNIFRDAGVPVRTYRYYDPKTRGLDFDG 183

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 162 LQASLSEAQAGDVVLFHGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARG-LEEDAEGLRAFAALHKELIV 240
Cdd:PLN02397 184 LLEDLKAAPDGSFVLLHACAHNPTGVDPTPEQWEQISDLIKSKNHLPFFDSAYQGFASGdLDADAQSVRMFVEDGHEILV 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 241 ASSYSKNFGLYNERVGACTLVAADAETVDRAFSQMKSAIRANYSNPPAHGASIVATILSNDALCAIWEQELTDMRQRIQR 320
Cdd:PLN02397 264 AQSYAKNMGLYGERVGALSVVCKSADVAVRVKSQLKLIARPMYSNPPIHGASIVATILGDPELFSEWTKELKGMADRIIS 343

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446384850 321 MRQLFVNTLQEKGANRDFSFIIKQNGMFSFSGLTKDQVLRLREEFGIYAVASGRVNVAGMTPDNMAPLCEAIVAV 395
Cdd:PLN02397 344 MRQKLYDALEARGSPGDWSHITKQIGMFSFTGLNKEQVDRMTKEYHIYMTRDGRISMAGLSSKNVPYLADAIHAV 418
Aminotran_1_2 pfam00155
Aminotransferase class I and II;
26-392 9.36e-106

Aminotransferase class I and II;


Pssm-ID: 395103 [Multi-domain]  Cd Length: 351  Bit Score: 315.78  E-value: 9.36e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   26 PGKINLGIGVYKDETgktpvLTSVKKAEQYLLENETTKNYLGIDGIPEFARCTQELLFGkgSALINDKRARTAQTPGGTG 105
Cdd:pfam00155   1 TDKINLGSNEYLGDT-----LPAVAKAEKDALAGGTRNLYGPTDGHPELREALAKFLGR--SPVLKLDREAAVVFGSGAG 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  106 ALRIAADFLAKNtPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFEALQASLSEAQagdVVLFHGCCHNPT 185
Cdd:pfam00155  74 ANIEALIFLLAN-PGDAILVPAPTYASYIRIARLAGGEVVRYPLYDSNDFHLDFDALEAALKEKP---KVVLHTSPHNPT 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  186 GIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGlEEDAEGLRAFAALHKELIVASSYSKNFGLYNERVGACTlvaada 265
Cdd:pfam00155 150 GTVATLEELEKLLDLAKEHNILLLVDEAYAGFVFG-SPDAVATRALLAEGPNLLVVGSFSKAFGLAGWRVGYIL------ 222

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  266 eTVDRAFSQMKSAIRANYSnpPAHGASIVATILSNDALCAiweQELTDMRQRIQRMRQLFVNTLQEKGanrdFSFIIKQN 345
Cdd:pfam00155 223 -GNAAVISQLRKLARPFYS--STHLQAAAAAALSDPLLVA---SELEEMRQRIKERRDYLRDGLQAAG----LSVLPSQA 292

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446384850  346 GMFSFSGLTKDQVLR----LREEFGIYAVA--------SGRVNVAGMTPDNMAPLCEAI 392
Cdd:pfam00155 293 GFFLLTGLDPETAKElaqvLLEEVGVYVTPgsspgvpgWLRITVAGGTEEELEELLEAI 351
AAT_like cd00609
Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent ...
 29-392 1.74e-52

Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. The major groups in this CD corresponds to Aspartate aminotransferase a, b and c, Tyrosine, Alanine, Aromatic-amino-acid, Glutamine phenylpyruvate, 1-Aminocyclopropane-1-carboxylate synthase, Histidinol-phosphate, gene products of malY and cobC, Valine-pyruvate aminotransferase and Rhizopine catabolism regulatory protein.


Pssm-ID: 99734 [Multi-domain]  Cd Length: 350  Bit Score: 178.30  E-value: 1.74e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  29 INLGIGVYKDETGKtpvltSVKKAEQYLLENETTKNYLGIDGIPEFARCTQELLFGKGSalINDKRARTAQTPGGTGALR 108
Cdd:cd00609    1 IDLSIGEPDFPPPP-----EVLEALAAAALRAGLLGYYPDPGLPELREAIAEWLGRRGG--VDVPPEEIVVTNGAQEALS 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 109 IAADFLAKntPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFEALQASLSEAqaGDVVLFHgCCHNPTGID 188
Cdd:cd00609   74 LLLRALLN--PGDEVLVPDPTYPGYEAAARLAGAEVVPVPLDEEGGFLLDLELLEAAKTPK--TKLLYLN-NPNNPTGAV 148

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 189 PTLEQWQALAELSVEKGWLPLFDFAYQGFARglEEDAEGLRAFAALHKELIVASSYSKNFGLYNERVGActLVAADAEtv 268
Cdd:cd00609  149 LSEEELEELAELAKKHGILIISDEAYAELVY--DGEPPPALALLDAYERVIVLRSFSKTFGLPGLRIGY--LIAPPEE-- 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 269 drAFSQMKSAIRANYSNPPAHGASIVATILSNDalcaiwEQELTDMRQRIQRMRQLFVNTLQEKGanrDFSFIIKQNGMF 348
Cdd:cd00609  223 --LLERLKKLLPYTTSGPSTLSQAAAAAALDDG------EEHLEELRERYRRRRDALLEALKELG---PLVVVKPSGGFF 291

                        330       340       350       360       370
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446384850 349 SF----SGLTKDQVLRLREEFGIYAVASG----------RVNVAGmTPDNMAPLCEAI 392
Cdd:cd00609  292 LWldlpEGDDEEFLERLLLEAGVVVRPGSafgeggegfvRLSFAT-PEEELEEALERL 348
AspB COG0436
Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; ...
 5-373 6.62e-17

Aspartate/methionine/tyrosine aminotransferase [Amino acid transport and metabolism]; Aspartate/methionine/tyrosine aminotransferase is part of the Pathway/BioSystem: Isoleucine, leucine, valine biosynthesis


Pssm-ID: 440205 [Multi-domain]  Cd Length: 387  Bit Score: 81.33  E-value: 6.62e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850   5 ITAAPADPILGLTDLFRADDRPGK--INLGIGvykDETGKTPvlTSVKKAEQYLLENETTKnYLGIDGIPEFaRctqell 82
Cdd:COG0436    7 LARLPPSPIREVSALAAELKAAGEdvIDLGIG---EPDFPTP--DHIREAAIEALDDGVTG-YTPSAGIPEL-R------ 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  83 fgkgSALINDKRART---------AQTPGGTGALRIAadFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAE 153
Cdd:COG0436   74 ----EAIAAYYKRRYgvdldpdeiLVTNGAKEALALA--LLALLNPGDEVLVPDPGYPSYRAAVRLAGGKPVPVPLDEEN 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 154 NHTLDFEALQASLSEAQAGdVVLfhgcC--HNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARGlEEDAEGLRAF 231
Cdd:COG0436  148 GFLPDPEALEAAITPRTKA-IVL----NspNNPTGAVYSREELEALAELAREHDLLVISDEIYEELVYD-GAEHVSILSL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 232 AALHKELIVASSYSKNFGLYNERVGACtlvAADAETVdRAFSQMKSAIRANYSNPPAHGAsivATILSNDalcaiwEQEL 311
Cdd:COG0436  222 PGLKDRTIVINSFSKSYAMTGWRIGYA---VGPPELI-AALLKLQSNLTSCAPTPAQYAA---AAALEGP------QDYV 288

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446384850 312 TDMRQRIQRMRQLFVNTLQEKGanrdFSFIIKQNGMF---SFSGLTKDQ---VLRLREEFGIyAVASG 373
Cdd:COG0436  289 EEMRAEYRRRRDLLVEGLNEIG----LSVVKPEGAFYlfaDVPELGLDSeefAERLLEEAGV-AVVPG 351
PRK08637 PRK08637
hypothetical protein; Provisional
 70-294 1.47e-10

hypothetical protein; Provisional


Pssm-ID: 181512  Cd Length: 388  Bit Score: 62.28  E-value: 1.47e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  70 GIPEFARCTQELLFGKGSALINDKRARTAQTPGGTGALRIAAD-FLAKNtpvKRVWVSNPSWPNHKSVFNAA-GLEVREY 147
Cdd:PRK08637  45 GIPELRDLWQEKMLRENPSLSGKKMSLPIVTNALTHGLSLVADlFVDQG---DTVLLPDHNWGNYKLTFNTRrGAEIVTY 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 148 AYYDAENHtLDFEALQASLSEAQAGD-VVLFHGCCHNPTGIDPTLEQWQALAEL---SVEKGW--LPLFDFAYQGFargL 221
Cdd:PRK08637 122 PIFDEDGG-FDTDALKEALQAAYNKGkVIVILNFPNNPTGYTPTEKEATAIVEAikeLADAGTkvVAVVDDAYFGL---F 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 222 EEDA--EGL-RAFAALHKELI---VASSYSKNF--GLyneRVGACTL--VAADAETVDRAFSQ-MKSAIRANYSNPPAHG 290
Cdd:PRK08637 198 YEDSykESLfAALANLHSNILavkLDGATKEEFvwGF---RVGFITFgtKAGSSQTVKEALEKkVKGLIRSNISNGPHPS 274


                 ....
gi 446384850 291 ASIV 294
Cdd:PRK08637 275 QSAV 278
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
 100-396 2.04e-10

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 62.15  E-value: 2.04e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 100 TPGGTGALRIAADFLAKntPVKRVWVSNPSWPNHKSVFNAAGLEVREYAyYDAENhtLDFEALQASLSEAQAgDVVLFHG 179
Cdd:COG1167  176 TSGAQQALDLALRALLR--PGDTVAVESPTYPGALAALRAAGLRLVPVP-VDEDG--LDLDALEAALRRHRP-RAVYVTP 249

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 180 CCHNPTGIDPTLEQWQALAELSVEKG-WL----PLFDFAYQGfargleedaEGLRAFAAL-HKEL-IVASSYSKNF--GL 250
Cdd:COG1167  250 SHQNPTGATMSLERRRALLELARRHGvPIieddYDSELRYDG---------RPPPPLAALdAPGRvIYIGSFSKTLapGL 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 251 yneRVGActlVAADAETVDRafsqMKSAIRANYSNPPAHGASIVATILSNDAlcaiWEQELTDMRQRIQRMRQLFVNTLQ 330
Cdd:COG1167  321 ---RLGY---LVAPGRLIER----LARLKRATDLGTSPLTQLALAEFLESGH----YDRHLRRLRREYRARRDLLLAALA 386

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 331 EKgANRDFSFIIKQNGMFSF----SGLTKDQVLRLREEFGIyAVASG-------------RVNVAGMTPDNMAPLCEAIV 393
Cdd:COG1167  387 RH-LPDGLRVTGPPGGLHLWlelpEGVDAEALAAAALARGI-LVAPGsafsadgpprnglRLGFGAPSEEELEEALRRLA 464


                 ...
gi 446384850 394 AVL 396
Cdd:COG1167  465 ELL 467
AAT_I cd01494
Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP) ...
 73-249 2.79e-09

Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the substrate in four kinds of reactions (1) transamination (movement of amino groups), (2) racemization (redistribution of enantiomers), (3) decarboxylation (removing COOH groups), and (4) various side-chain reactions depending on the enzyme involved. Pyridoxal phosphate (PLP) dependent enzymes were previously classified into alpha, beta and gamma classes, based on the chemical characteristics (carbon atom involved) of the reaction they catalyzed. The availability of several structures allowed a comprehensive analysis of the evolutionary classification of PLP dependent enzymes, and it was found that the functional classification did not always agree with the evolutionary history of these enzymes. Structure and sequence analysis has revealed that the PLP dependent enzymes can be classified into four major groups of different evolutionary origin: aspartate aminotransferase superfamily (fold type I), tryptophan synthase beta superfamily (fold type II), alanine racemase superfamily (fold type III), and D-amino acid superfamily (fold type IV) and Glycogen phophorylase family (fold type V).


Pssm-ID: 99742 [Multi-domain]  Cd Length: 170  Bit Score: 55.85  E-value: 2.79e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  73 EFARCTQELLFGKGSALIndkrartaQTPGGTGALRIAADFLAKN-TPVkrVWVSNPSWPNHKSVFNAAGLEVREYAYYD 151
Cdd:cd01494    4 ELEEKLARLLQPGNDKAV--------FVPSGTGANEAALLALLGPgDEV--IVDANGHGSRYWVAAELAGAKPVPVPVDD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 152 AEnhtlDFEALQASLSEAQAGD---VVLFHGCCHNPTGIDPTLEqwqaLAELSVEKGWLPLFDFAYQGFARGLEEDAEGl 228
Cdd:cd01494   74 AG----YGGLDVAILEELKAKPnvaLIVITPNTTSGGVLVPLKE----IRKIAKEYGILLLVDAASAGGASPAPGVLIP- 144

                        170       180
                 ....*....|....*....|.
gi 446384850 229 rafaaLHKELIVASSYSKNFG 249
Cdd:cd01494  145 -----EGGADVVTFSLHKNLG 160
PRK06225 PRK06225
pyridoxal phosphate-dependent aminotransferase;
100-263 1.69e-08

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 235749 [Multi-domain]  Cd Length: 380  Bit Score: 55.91  E-value: 1.69e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 100 TPGGTGALRIAADFLAKntPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAE-NHTLDFEALQASLSEAQAgdvVLFH 178
Cdd:PRK06225  89 TAGATESLYLVMRAFLS--PGDNAVTPDPGYLIIDNFASRFGAEVIEVPIYSEEcNYKLTPELVKENMDENTR---LIYL 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 179 GCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFARG----LEEDAEGlrafaalhkeLIVASSYSKNFGLYNER 254
Cdd:PRK06225 164 IDPLNPLGSSYTEEEIKEFAEIARDNDAFLLHDCTYRDFAREhtlaAEYAPEH----------TVTSYSFSKIFGMAGLR 233


                 ....*....
gi 446384850 255 VGActLVAA 263
Cdd:PRK06225 234 IGA--VVAT 240
HisC COG0079
Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid ...
 100-333 3.91e-08

Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase [Amino acid transport and metabolism]; Histidinol-phosphate/aromatic aminotransferase or cobyric acid decarboxylase is part of the Pathway/BioSystem: Cobalamine/B12 biosynthesis


Pssm-ID: 439849 [Multi-domain]  Cd Length: 341  Bit Score: 54.37  E-value: 3.91e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 100 TPGGTGALRIAadFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYydAENHTLDFEALQASLSEAqaGDVVLFhg 179
Cdd:COG0079   71 GNGSDELIQLL--ARAFLGPGDEVLVPEPTFSEYPIAARAAGAEVVEVPL--DEDFSLDLDALLAAITER--TDLVFL-- 142

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 180 cC--HNPTGIDPTLEQWQALAELSVEKGWLpLFDFAYQGFArgleEDAEGLRAFAALHKELIVASSYSKNFGLYNERVGa 257
Cdd:COG0079  143 -CnpNNPTGTLLPREELEALLEALPADGLV-VVDEAYAEFV----PEEDSALPLLARYPNLVVLRTFSKAYGLAGLRLG- 215

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446384850 258 ctLVAADAETVDRAfsqmkSAIRANYS-NPPAHGASIVAtiLSNDAlcaiweqELTDMRQRIQRMRQLFVNTLQEKG 333
Cdd:COG0079  216 --YAIASPELIAAL-----RRVRGPWNvNSLAQAAALAA--LEDRA-------YLEETRARLRAERERLAAALRALG 276
PRK06108 PRK06108
pyridoxal phosphate-dependent aminotransferase;
96-256 1.14e-05

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180404  Cd Length: 382  Bit Score: 46.86  E-value: 1.14e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  96 RTAQTPGGTGALRIAADFLAknTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAY-YDAENHTLDFEALQASLSEAQAgdv 174
Cdd:PRK06108  86 RIAVTSSGVQALMLAAQALV--GPGDEVVAVTPLWPNLVAAPKILGARVVCVPLdFGGGGWTLDLDRLLAAITPRTR--- 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 175 VLFHGCCHNPTGIDPTLEQWQALAELSVEKG-WLpLFDFAYQGFARGLEEDAEGLRAFAALHKELIVASSYSKNFGLYNE 253
Cdd:PRK06108 161 ALFINSPNNPTGWTASRDDLRAILAHCRRHGlWI-VADEVYERLYYAPGGRAPSFLDIAEPDDRIIFVNSFSKNWAMTGW 239


                 ...
gi 446384850 254 RVG 256
Cdd:PRK06108 240 RLG 242
PLN00175 PLN00175
aminotransferase family protein; Provisional
 70-256 7.54e-04

aminotransferase family protein; Provisional


Pssm-ID: 215089 [Multi-domain]  Cd Length: 413  Bit Score: 41.39  E-value: 7.54e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  70 GIPEFARCTQELlFGKGSALINDKRARTAQTPGGTGAlrIAADFLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAY 149
Cdd:PLN00175  92 GVPELNSAIAER-FKKDTGLVVDPEKEVTVTSGCTEA--IAATILGLINPGDEVILFAPFYDSYEATLSMAGAKIKTVTL 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 150 YdAENHTLDFEALQASLSEAQAGDVVlfhGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQGFArgLEEDAEGLR 229
Cdd:PLN00175 169 R-PPDFAVPEDELKAAFTSKTRAILI---NTPHNPTGKMFTREELELIASLCKENDVLAFTDEVYDKLA--FEGDHISMA 242

                        170       180
                 ....*....|....*....|....*..
gi 446384850 230 AFAALHKELIVASSYSKNFGLYNERVG 256
Cdd:PLN00175 243 SLPGMYERTVTMNSLGKTFSLTGWKIG 269
PRK07337 PRK07337
pyridoxal phosphate-dependent aminotransferase;
95-256 5.90e-03

pyridoxal phosphate-dependent aminotransferase;


Pssm-ID: 180937  Cd Length: 388  Bit Score: 38.50  E-value: 5.90e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850  95 ARTAQTPGGTGALRIAAdfLAKNTPVKRVWVSNPSWPNHKSVFNAAGLEVREYAYYDAENHTLDFEALQASLSEAQAGdV 174
Cdd:PRK07337  91 ERIVVTAGASAALLLAC--LALVERGDEVLMPDPSYPCNRHFVAAAEGRPVLVPSGPAERFQLTAADVEAAWGERTRG-V 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446384850 175 VLfhGCCHNPTGIDPTLEQWQALAELSVEKGWLPLFDFAYQgfarGLEEDAEGLRAFaALHKELIVASSYSKNFGLYNER 254
Cdd:PRK07337 168 LL--ASPSNPTGTSIAPDELRRIVEAVRARGGFTIVDEIYQ----GLSYDAAPVSAL-SLGDDVITINSFSKYFNMTGWR 240


                 ..
gi 446384850 255 VG 256
Cdd:PRK07337 241 LG 242
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
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