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Conserved domains on  [gi|446382673|ref|WP_000460528|]
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cysteine desulfidase [Escherichia coli]

Protein Classification

serine dehydratase subunit alpha family protein( domain architecture ID 10007829)

serine dehydratase subunit alpha family protein such as L-cysteine desulfidase, which catalyzes the cleavage of L-cysteine to form 2-aminoprop-2-enoate and sulfide

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
7-436 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


:

Pssm-ID: 442897  Cd Length: 429  Bit Score: 601.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673   7 NPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALG 86
Cdd:COG3681    3 TELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGAVG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  87 GNANAGLEVLKDATAQAISDAKALLAAGKVSVKIQEpCDEILFSRAKVWNGEKWACVTIVGGHTNIVHIEtHNGVVFTQQ 166
Cdd:COG3681   83 GDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKE-TDEGLYIEATVKTGDHSARVVIEGSHTNIVLIE-KNGEVLFEK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 167 ACVAEGEqESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGNWGLHIGATLEKQCARGLLAKDLSS 246
Cdd:COG3681  161 ESSAASE-ESLLEDLKKLSIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDLLS 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 247 SIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAAT 326
Cdd:COG3681  240 RARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCGAV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 327 TAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVE 406
Cdd:COG3681  320 VAGAGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGEDVE 399
                        410       420       430
                 ....*....|....*....|....*....|
gi 446382673 407 QSIANLCALASHSMQQTDRQIIEIMASKAR 436
Cdd:COG3681  400 ETIRNLGRLASEGMKETDKEILEIMLKKQK 429
 
Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
7-436 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


Pssm-ID: 442897  Cd Length: 429  Bit Score: 601.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673   7 NPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALG 86
Cdd:COG3681    3 TELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGAVG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  87 GNANAGLEVLKDATAQAISDAKALLAAGKVSVKIQEpCDEILFSRAKVWNGEKWACVTIVGGHTNIVHIEtHNGVVFTQQ 166
Cdd:COG3681   83 GDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKE-TDEGLYIEATVKTGDHSARVVIEGSHTNIVLIE-KNGEVLFEK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 167 ACVAEGEqESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGNWGLHIGATLEKQCARGLLAKDLSS 246
Cdd:COG3681  161 ESSAASE-ESLLEDLKKLSIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDLLS 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 247 SIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAAT 326
Cdd:COG3681  240 RARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCGAV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 327 TAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVE 406
Cdd:COG3681  320 VAGAGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGEDVE 399
                        410       420       430
                 ....*....|....*....|....*....|
gi 446382673 407 QSIANLCALASHSMQQTDRQIIEIMASKAR 436
Cdd:COG3681  400 ETIRNLGRLASEGMKETDKEILEIMLKKQK 429
SDH_alpha pfam03313
Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer ...
202-429 4.30e-56

Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.


Pssm-ID: 427238  Cd Length: 259  Bit Score: 186.08  E-value: 4.30e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  202 RFILDSAKLNCALSQEGLSGNwglhigatlEKQCARGLLAKDLSSSIV--IRTSAASDARMGGATLPAMSNSGSGNQGIt 279
Cdd:pfam03313  36 EFMLEAIEMNLAISEEGLLPG---------GLKVRRRNYGLGLGGTLLdkALAAAAADARMNGAMGPVVTAPTSGNQGI- 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  280 atMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALC----AATTAAMGAAAGMAWLVDGRYETISMAISSMI 355
Cdd:pfam03313 106 --LPAVLYAEELGASEEKLIRALLLSALIGIYIKKNAGILSAECgcqaEVGSASAMAAAGLAYLLGGTPEQIENAAENAL 183
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446382673  356 GDVSGMICDG----ASNSCAMKVSTSASAAWKAVLMALDDtavTGNEGIVAHD-VEQSIANLCALASHSMQQTDRQIIE 429
Cdd:pfam03313 184 ENLLGLICDPvaglVKVPCAEKNATGAVAAILAALMALAG---DGIDGIVPLDeVIETMRNVGRLMPEGMKETDLGGLA 259
 
Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
7-436 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


Pssm-ID: 442897  Cd Length: 429  Bit Score: 601.36  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673   7 NPLWQRYILAVQEEVKPALGCTEPISLALAAAVAAAELEGPVERVEAWVSPNLMKNGLGVTVPGTGMVGLPIAAALGALG 86
Cdd:COG3681    3 TELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGAVG 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  87 GNANAGLEVLKDATAQAISDAKALLAAGKVSVKIQEpCDEILFSRAKVWNGEKWACVTIVGGHTNIVHIEtHNGVVFTQQ 166
Cdd:COG3681   83 GDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKE-TDEGLYIEATVKTGDHSARVVIEGSHTNIVLIE-KNGEVLFEK 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 167 ACVAEGEqESPLTVLSRTTLAEILKFVNEVPFAAIRFILDSAKLNCALSQEGLSGNWGLHIGATLEKQCARGLLAKDLSS 246
Cdd:COG3681  161 ESSAASE-ESLLEDLKKLSIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDLLS 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 247 SIVIRTSAASDARMGGATLPAMSNSGSGNQGITATMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALCAAT 326
Cdd:COG3681  240 RARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCGAV 319
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673 327 TAAMGAAAGMAWLVDGRYETISMAISSMIGDVSGMICDGASNSCAMKVSTSASAAWKAVLMALDDTAVTGNEGIVAHDVE 406
Cdd:COG3681  320 VAGAGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGEDVE 399
                        410       420       430
                 ....*....|....*....|....*....|
gi 446382673 407 QSIANLCALASHSMQQTDRQIIEIMASKAR 436
Cdd:COG3681  400 ETIRNLGRLASEGMKETDKEILEIMLKKQK 429
SDH_alpha pfam03313
Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer ...
202-429 4.30e-56

Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.


Pssm-ID: 427238  Cd Length: 259  Bit Score: 186.08  E-value: 4.30e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  202 RFILDSAKLNCALSQEGLSGNwglhigatlEKQCARGLLAKDLSSSIV--IRTSAASDARMGGATLPAMSNSGSGNQGIt 279
Cdd:pfam03313  36 EFMLEAIEMNLAISEEGLLPG---------GLKVRRRNYGLGLGGTLLdkALAAAAADARMNGAMGPVVTAPTSGNQGI- 105
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446382673  280 atMPVVVVAEHFGADDERLARALMLSHLSAIYIHNQLPRLSALC----AATTAAMGAAAGMAWLVDGRYETISMAISSMI 355
Cdd:pfam03313 106 --LPAVLYAEELGASEEKLIRALLLSALIGIYIKKNAGILSAECgcqaEVGSASAMAAAGLAYLLGGTPEQIENAAENAL 183
                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446382673  356 GDVSGMICDG----ASNSCAMKVSTSASAAWKAVLMALDDtavTGNEGIVAHD-VEQSIANLCALASHSMQQTDRQIIE 429
Cdd:pfam03313 184 ENLLGLICDPvaglVKVPCAEKNATGAVAAILAALMALAG---DGIDGIVPLDeVIETMRNVGRLMPEGMKETDLGGLA 259
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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