|
Name |
Accession |
Description |
Interval |
E-value |
| umuC |
PRK03609 |
translesion error-prone DNA polymerase V subunit UmuC; |
1-422 |
0e+00 |
|
translesion error-prone DNA polymerase V subunit UmuC;
Pssm-ID: 179607 [Multi-domain] Cd Length: 422 Bit Score: 910.30 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 1 MFALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
Cdd:PRK03609 1 MFALCDVNSFYASCETVFRPDLRGKPVVVLSNNDGCVIARSAEAKALGIKMGDPWFKQKDLFRRCGVVCFSSNYELYADM 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT 160
Cdd:PRK03609 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRQT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 161 GGVVDLSNLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEF 240
Cdd:PRK03609 161 GGVVDLSNLERQRKLLSLQPVEEVWGVGRRISKKLNAMGIKTALDLADTNIRFIRKHFNVVLERTVRELRGEPCLSLEEF 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 241 APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSASVKLLTPTQDSR 320
Cdd:PRK03609 241 APTKQEIVCSRSFGERITDYESMRQAICSYAARAAEKLRGEHQYCRFISTFVKTSPFALNEPYYGNSASVKLLTPTQDSR 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 321 DIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMAVMDTLNAKEGRGTLYFAGQGIQQQW 400
Cdd:PRK03609 321 DIIAAATRALDAIWRDGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRPGSEQLMKVLDTLNAKSGKGTLYFAGQGIAQQW 400
|
410 420
....*....|....*....|..
gi 446379777 401 QMKRAMLSPRYTTRSSDLLRVK 422
Cdd:PRK03609 401 QMKREMLSPRYTTRWSDLLRVK 422
|
|
| PolY_Pol_V_umuC |
cd01700 |
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion ... |
3-349 |
0e+00 |
|
umuC subunit of DNA Polymerase V; umuC subunit of Pol V. Pol V is a bacterial translesion synthesis (TLS) polymerase that consists of the heterotrimer of one umuC and two umuD subunits. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol V, RecA, single stranded DNA-binding protein, beta sliding clamp, and gamma clamp loading complex are responsible for inducing the SOS response in bacteria to repair UV-induced DNA damage.
Pssm-ID: 176454 [Multi-domain] Cd Length: 344 Bit Score: 544.06 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 3 ALCDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVCFSSNYELYADMSN 82
Cdd:cd01700 1 ALVDCNSFYASCERVFRPLLLGRPLVVLSNNDGCVIARSPEAKALGIKMGSPYFKVPDLLERHGVAVFSSNYALYGDMSR 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 83 RVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQRqTGG 162
Cdd:cd01700 81 RIMSILERFSPDVEVYSIDESFLDLTGSLRFGDLEELARKIRRRILQETGIPVTVGIGPTKTLAKLANDLAKKKNP-YGG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 163 VVDLSNLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEEFAP 242
Cdd:cd01700 160 VVDLTDEEVRDKLLKILPVGDVWGIGRRTAKKLNAMGIHTAGDLAQADPDLLRKKFGVVGERLVRELNGIDCLPLEEYPP 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 243 TKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYgnSASVKLLTPTQDSRDI 322
Cdd:cd01700 240 PKKSIGSSRSFGRDVTDLDELKQALAEYAERAAEKLRRQKSVARTISVFIGTSGFSRQPKYY--SATNTLPYPTNDTREI 317
|
330 340
....*....|....*....|....*..
gi 446379777 323 INAATRSLDAIWQAGHRYQKAGVMLGD 349
Cdd:cd01700 318 VKAALRLLYAIYRPGYAYRKAGVMLSD 344
|
|
| DinP |
COG0389 |
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination ... |
1-347 |
3.68e-140 |
|
Nucleotidyltransferase/DNA polymerase DinP involved in DNA repair [Replication, recombination and repair];
Pssm-ID: 440158 [Multi-domain] Cd Length: 336 Bit Score: 403.76 E-value: 3.68e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 1 MFALCDVNAFYASCETVFRPDLWGKPVVVLS-NNDGCVIARNAEAKALGVKMGDPWFKQKdlfRRC-GVVCFSSNYELYA 78
Cdd:COG0389 2 RILHVDMDAFYASVEQRDRPELRGKPVAVGGdNNRGVVAAASYEARAFGVRSGMPLFQAR---RLCpDLVVLPPDFELYR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 79 DMSNRVMSTLEELSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwq 157
Cdd:COG0389 79 DVSRRVMAILERYTPLVEPLSIDEAFLDVTGsARLFGSAEAIARRIRRRIRRETGLTVSVGIAPNKFLAKIASDLAKP-- 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 158 rqtGGVVDLSnLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQL 237
Cdd:COG0389 157 ---DGLTVIP-PGEVAAFLAPLPVEKLWGVGPKTAEKLARLGIRTIGDLAALPRAELRRRFGKVGERLYRLARGIDPRPV 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 238 EEFAPTKQeIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALnepyygNSASVKLLTPTQ 317
Cdd:COG0389 233 EPRRPRKS-IGVERTFGEDLTDLEELEAALRRLAERLAERLRRQGLGARTVTVKLRTSDFRT------TTRSRTLPEPTD 305
|
330 340 350
....*....|....*....|....*....|
gi 446379777 318 DSRDIINAATRSLDAIWQAGHRYQKAGVML 347
Cdd:COG0389 306 DTAELLRAARELLERIYRPGRPVRLLGVRL 335
|
|
| PolY_Pol_IV_kappa |
cd03586 |
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion ... |
5-335 |
2.99e-66 |
|
DNA Polymerase IV/Kappa; Pol IV, also known as Pol kappa, DinB, and Dpo4, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Known primarily as Pol IV in prokaryotes and Pol kappa in eukaryotes, this polymerase has a propensity for generating frameshift mutations. The eukaryotic Pol kappa differs from Pol IV and Dpo4 by an N-terminal extension of ~75 residues known as the "N-clasp" region. The structure of Pol kappa shows DNA that is almost totally encircled by Pol kappa, with the N-clasp region augmenting the interactions between DNA and the polymerase. Pol kappa is more resistant than Pol eta and Pol iota to bulky guanine adducts and is efficient at catalyzing the incorporation of dCTP. Bacterial pol IV has a higher error rate than other Y-family polymerases.
Pssm-ID: 176459 [Multi-domain] Cd Length: 334 Bit Score: 214.69 E-value: 2.99e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 5 CDVNAFYASCETVFRPDLWGKPVVVLSNNDGCVIAR-NAEAKALGVKMGDPWFKQKdlfRRC--GVVcFSSNYELYADMS 81
Cdd:cd03586 3 IDMDAFYASVEQRDNPELKGKPVAVGGSSDRGVVSTaSYEARKFGVRSAMPIFQAK---KLCpnLIF-VPPRFDKYREVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDL-TDFGREIRATVLQRTHLTVGVGIAQTKTLAKLA-NHAakKWQRQ 159
Cdd:cd03586 79 RQIMEILREYTPLVEPLSIDEAYLDVTDYVRLFGSaTEIAKEIRARIREETGLTASAGIAPNKFLAKIAsDLN--KPNGL 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 160 TggVVDLSNLErqrKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEE 239
Cdd:cd03586 157 T--VIPPEDVE---EFLAPLPVRKIPGVGKVTAEKLKELGIKTIGDLAKLDVELLKKLFGKSGRRLYELARGIDNRPVEP 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 240 FAPTKQeIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALnepyygNSASVKLLTPTQDS 319
Cdd:cd03586 232 DRERKS-IGVERTFSEDLTDPEELLEELLELAEELAERLRKRGLKGRTVTVKLKYADFST------RTRSRTLPEPTDDA 304
|
330
....*....|....*.
gi 446379777 320 RDIINAATRSLDAIWQ 335
Cdd:cd03586 305 EDIYELALELLEELLD 320
|
|
| PolY |
cd00424 |
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases ... |
6-348 |
6.21e-61 |
|
Y-family of DNA polymerases; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Most TLS polymerases are members of the Y-family, including Pol eta, Pol kappa/IV, Pol iota, Rev1, and Pol V, which is found exclusively in bacteria. In eukaryotes, the B-family polymerase Pol zeta also functions as a TLS polymerase. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176453 [Multi-domain] Cd Length: 343 Bit Score: 201.05 E-value: 6.21e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVLSNND--GCVIARNAEAKALGVKMGDPWFKQKDLFRRCGVVcfSSNYELYADMSNR 83
Cdd:cd00424 4 DFDNFFASVEQLARPELKGRPVVVVPFNSdsTCVIACSYEARKYGVKRGMPVREARKMCPNLILV--PARLDLYRRLSER 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 84 VMSTLEELSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGREIRATVLQRT-HLTVGVGIAQTKTLAKLANHAAKKWQRQtg 161
Cdd:cd00424 82 LLSELEEVAPLVEVASIDELFLDLTGsARLLGLGSEVALRIKRHIAEQLgGITASIGIASNKLLAKLAAKYAKPDGLT-- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 162 gVVDLSNLERqrkLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKH-FNVVLERTVRELRGEPCLQLEEf 240
Cdd:cd00424 160 -ILDPEDLPG---FLSKLPLTDLPGIGAVTAKRLEAVGINPIGDLLAASPDALLALwGGVSGERLWYALRGIDDEPLSP- 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 241 APTKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALNEPYYGNSASVKLLTPTQDSR 320
Cdd:cd00424 235 PRPRKSFSHERVLPRDSRNAEDARPLLRLLLEKLARRLRRDGRGATRLRLWLRTVDGRWSGHADIPSRSAPRPISTEDGE 314
|
330 340 350
....*....|....*....|....*....|....
gi 446379777 321 diinaATRSLDAIWQAGH------RYQKAGVMLG 348
Cdd:cd00424 315 -----LLHALDKLWRALLddkgprRLRRLGVRLS 343
|
|
| PRK03103 |
PRK03103 |
DNA polymerase IV; Reviewed |
4-392 |
2.42e-50 |
|
DNA polymerase IV; Reviewed
Pssm-ID: 235104 [Multi-domain] Cd Length: 409 Bit Score: 175.19 E-value: 2.42e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 4 LCDVNAFYASCETVFRPDLWGKPVVVL---SNNDGCVIARNAEAKALGVKMGDPWFKQKdlfRRC--GVVcFSSNYELYA 78
Cdd:PRK03103 7 LVDMQSFYASVEKAANPELKGRPVIVSgdpERRSGVVLAACPLAKAYGVKTAERLWEAQ---QKCpdLVV-VKPRMQRYI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 79 DMSNRVMSTLEELSPRVEIYSIDEAFCDLTGvrnCRDLtdFG------REIRATVLQRTHLTVGVGIAQTKTLAKLA-NH 151
Cdd:PRK03103 83 DVSLQITRILEDFTDLVEPFSIDEQFLDVTG---SQKL--FGspleiaQKIQQRIMRETGVYARVGIGPNKLLAKMAcDN 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 152 AAKKwqrQTGGVVDLsNLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNV---VLERTVRE 228
Cdd:PRK03103 158 FAKK---NPDGLFTL-DKEDVPADLWPLPVRKLFGVGSRMEKHLRRMGIRTIGQLANTPLERLKKRWGIngeVLWRTANG 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 229 LRGEPclqLEEFAPTKQeiicsRSFGERIT---DYTS---MRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFalnEP 302
Cdd:PRK03103 234 IDYSP---VTPHSLDRQ-----KAIGHQMTlprDYRGfeeIKVVLLELCEEVCRRARAKGYMGRTVSVSLRGADF---DW 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 303 YYGNSASVKLLTPTQDSRDIINAATRSLDAIWQaGHRYQKAGVMLGDFFSQGVAQLNLFDDNAPRpgsEQLMAVMDTLNA 382
Cdd:PRK03103 303 PTGFSRQMTLPEPTNLAMEVYEAACKLFHRHWD-GKPVRRVGVTLSNLVSDDVWQLSLFGDRERK---RSLGYVMDDIKN 378
|
410
....*....|
gi 446379777 383 KEGRGTLYFA 392
Cdd:PRK03103 379 RFGPTAILRA 388
|
|
| IMS |
pfam00817 |
impB/mucB/samB family; These proteins are involved in UV protection (Swiss). |
5-149 |
2.08e-48 |
|
impB/mucB/samB family; These proteins are involved in UV protection (Swiss).
Pssm-ID: 425885 [Multi-domain] Cd Length: 148 Bit Score: 161.97 E-value: 2.08e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 5 CDVNAFYASCETVFRPDLWGKPVVVLSNN-DGCVIARNAEAKALGVKMGDPWFKQKDLFRRcgVVCFSSNYELYADMSNR 83
Cdd:pfam00817 1 IDMDAFFASVELLRDPELKGKPVAVGGGNgRGIVAAASYEARKYGVRSGMPVFEAKKLCPN--LIVVPPDLELYRRASRK 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446379777 84 VMSTLEEL-SPRVEIYSIDEAFCDLTGVRNCRDLT-DFGREIRATVLQRTHLTVGVGIAQTKTLAKLA 149
Cdd:pfam00817 79 IFEILRRFsTPKVEQASIDEAFLDLTGLEKLFGAEeALAKRLRREIAEETGLTCSIGIAPNKLLAKLA 146
|
|
| PRK01810 |
PRK01810 |
DNA polymerase IV; Validated |
6-389 |
4.39e-41 |
|
DNA polymerase IV; Validated
Pssm-ID: 179337 [Multi-domain] Cd Length: 407 Bit Score: 150.18 E-value: 4.39e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVLSN---NDGCVIARNAEAKALGVKMGDPWFKQKdlfRRC-GVVCFSSNYELYADMS 81
Cdd:PRK01810 11 DMNSFFASVEIAYDPSLQGKPLAVAGNekeRKGIIVTCSYEARAYGIRTTMPLWEAK---RLCpQLIVRRPNFDRYREAS 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWqrqtg 161
Cdd:PRK01810 88 RQMFQILSEFTPLVQPVSIDEGYLDITDCYALGSPLEIAKMIQQRLLTELQLPCSIGIAPNKFLAKMASDMKKPL----- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 162 GVVDLSNLERQRKLMSaLSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGE------PcL 235
Cdd:PRK01810 163 GITVLRKRDVPEMLWP-LPVGEMHGIGEKTAEKLKDIGIQTIGDLAKADEHILRAKLGINGVRLQRRANGIddrpvdP-E 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 236 QLEEFaptkQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAlnepyyGNSASVKLLTP 315
Cdd:PRK01810 241 AIYQF----KSVGNSTTLSHDMDEEKELLDVLRRLSKSVSKRLQKKTVVSYNVQIMIRYHDRR------TITRSKTLKNP 310
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446379777 316 TQDSRDIINAATRSLDAIWQaGHRYQKAGVMLGDFF--SQGVAQLNLFD--DNAPRpgsEQLMAVMDTLNAKEGRGTL 389
Cdd:PRK01810 311 IWEKRDIFQAASRLFKQHWN-GDPVRLLGVTATDLEwkTEAVKQLDLFSfeEDAKE---EPLLAVIDQINDKYGMPLL 384
|
|
| PRK03348 |
PRK03348 |
DNA polymerase IV; Provisional |
6-379 |
1.26e-39 |
|
DNA polymerase IV; Provisional
Pssm-ID: 235118 [Multi-domain] Cd Length: 454 Bit Score: 147.39 E-value: 1.26e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVV--LSNNdGCVIARNAEAKALGVKMGDPWFKQKdlfRRCGV--VCFSSNYELYADMS 81
Cdd:PRK03348 11 DMDAFFASVEQLTRPTLRGRPVLVggLGGR-GVVAGASYEARVFGARSAMPMHQAR---RLVGNgaVVLPPRFVVYRAAS 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGV--RNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrq 159
Cdd:PRK03348 87 RRVFDTLRELSPVVEQLSFDEAFVEPAELagASAEEVEAFAERLRARVREETGLPASVGAGSGKQIAKIASGLAKP---- 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 160 tGGVVdLSNLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKhfnvVLERTV-REL----RGEPC 234
Cdd:PRK03348 163 -DGIR-VVPPGEERELLAPLPVRRLWGIGPVTEEKLHRLGIETIGDLAALSEAEVAN----LLGATVgPALhrlaRGIDD 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 235 LQLEEFAPTKQeIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALnepyygNSASVKLLT 314
Cdd:PRK03348 237 RPVAERAEAKQ-ISAESTFAVDLTTRAQLREAIERIAEHAHRRLLKDGRGARTVTVKLRKSDFST------LTRSATLPY 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446379777 315 PTQDSRDIINAATRSLDAIWQAGhryqkaGV-MLGDFFS--QGVAQLNLF-DDNAPRPGSEQLMAVMDT 379
Cdd:PRK03348 310 ATDDAAVLAATARRLLLDPDEIG------PIrLVGVGFSglSDVRQESLFpELDLARETAPAEEVETES 372
|
|
| PRK03352 |
PRK03352 |
DNA polymerase IV; Validated |
6-333 |
1.22e-38 |
|
DNA polymerase IV; Validated
Pssm-ID: 179564 [Multi-domain] Cd Length: 346 Bit Score: 142.47 E-value: 1.22e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVLSNND-----GCVIARNAEAKALGVKMGDPWfkqKDLFRRC-GVVCFSSNYELYAD 79
Cdd:PRK03352 11 DLDQFIAAVELLRRPELAGLPVIVGGNGDpteprKVVTCASYEARAFGVRAGMPL---RTAARRCpDAVFLPSDPAAYDA 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 80 MSNRVMSTLEELSPRVEIYSIDEAFcdlTGVRNcRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrq 159
Cdd:PRK03352 88 ASEEVMATLRDLGVPVEVWGWDEAF---LGVDT-DDPEALAEEIRAAVLERTGLSCSVGIGDNKLRAKIATGFAKP---- 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 160 tGGVVDLSNlERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFN-------VVLERTV--RELR 230
Cdd:PRK03352 160 -AGVFRLTD-ANWMAVMGDRPTDALWGVGPKTAKRLAALGITTVADLAAADPAELAATFGpttgpwlLLLARGGgdTEVS 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 231 GEPCLQLeefaptkqeiicSRS----FGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFalnepyYGN 306
Cdd:PRK03352 238 AEPWVPR------------SRSrevtFPQDLTDRAEVESAVRELARRVLDEVVAEGRPVTRVAVKVRTATF------YTR 299
|
330 340
....*....|....*....|....*..
gi 446379777 307 SASVKLLTPTQDSRDIINAATRSLDAI 333
Cdd:PRK03352 300 TKIRKLPEPTTDPDVIEAAALDVLDRF 326
|
|
| PRK01216 |
PRK01216 |
DNA polymerase IV; Validated |
1-206 |
2.38e-32 |
|
DNA polymerase IV; Validated
Pssm-ID: 179251 [Multi-domain] Cd Length: 351 Bit Score: 125.29 E-value: 2.38e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 1 MFALCDVNAFYASCETVFRPDLWGKPVVVL-----SNNDGCVIARNAEAKALGVKMGDPWFKQKDLFRrcGVVCFSSNYE 75
Cdd:PRK01216 2 IILFVDFDYFFAQVEEVLNPSLKGKPVVVCvysgrFEDSGAVATANYEARKLGIKAGMPIVEAKKILP--NAVYLPMRKE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 76 LYADMSNRVMSTLEELSPRVEIYSIDEAFCDLTG-VRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAK 154
Cdd:PRK01216 80 VYQQVSNRIMKLLREYSEKIEIASIDEAYLDISDkVKNYQDAYNLGLEIKNKILEKEKITVTVGISKNKVFAKIAADMAK 159
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 446379777 155 KwqrqTG-GVVDLSNLERqrkLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDL 206
Cdd:PRK01216 160 P----NGiKVIDDEEVKR---FINELDIADIPGIGDITAEKLKKLGVNKLVDT 205
|
|
| PRK14133 |
PRK14133 |
DNA polymerase IV; Provisional |
6-361 |
5.06e-32 |
|
DNA polymerase IV; Provisional
Pssm-ID: 184529 [Multi-domain] Cd Length: 347 Bit Score: 124.44 E-value: 5.06e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVV--LSNNdGCVIARNAEAKALGVKMGDPWFKQKdlfRRC--GVVcFSSNYELYADMS 81
Cdd:PRK14133 9 DMDAFFASVEQMDNPKLKGKPVIVggISER-GVVSTCSYEARKYGVHSAMPVFMAK---KRCphGIF-LPVRHERYKEVS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRncRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANhaakKWQRQTG 161
Cdd:PRK14133 84 KNIFKILYEVTPIVEPVSIDEAYLDITNIK--EEPIKIAKYIKKKVKKETGLTLSVGISYNKFLAKLAS----DWNKPDG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 162 gvVDLSNLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRGEPCLQLEefa 241
Cdd:PRK14133 158 --IKIITEDMIPDILKPLPISKVHGIGKKSVEKLNNIGIYTIEDLLKLSREFLIEYFGKFGVEIYERIRGIDYREVE--- 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 242 pTKQEIicsRSFGERIT------DYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFALnepyygNSASVKLLTP 315
Cdd:PRK14133 233 -VSRER---KSIGKETTlkkdtkDKEELKKYLKDFSNIISEELKKRNLYGKTVTVKIKTSDFQT------HTKSKTLNDY 302
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446379777 316 TQDSRDIINAATRSLDAiWQAGHRYQKAGVMLGDFFSQGVAQLNLF 361
Cdd:PRK14133 303 IRDKEEIYNVACEILEH-INIKEPIRLIGLSVSNLSENKIEQLSFL 347
|
|
| PRK03858 |
PRK03858 |
DNA polymerase IV; Validated |
6-210 |
4.44e-28 |
|
DNA polymerase IV; Validated
Pssm-ID: 179663 [Multi-domain] Cd Length: 396 Bit Score: 114.31 E-value: 4.44e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVlsnNDGCVIARNAEAKALGVKMGDPWFKQKdlfRRC-GVVCFSSNYELYADMSNRV 84
Cdd:PRK03858 10 DLDSFYASVEQRDDPALRGRPVIV---GGGVVLAASYEAKAYGVRTAMGGRQAR---RLCpQAVVVPPRMSAYSRASKAV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 85 MSTLEELSPRVEIYSIDEAFCDLTGvrnCRDLT----DFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqt 160
Cdd:PRK03858 84 FEVFRDTTPLVEGLSIDEAFLDVGG---LRRISgtpvQIAARLRRRVREEVGLPITVGVARTKFLAKVASQVAKP----- 155
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 446379777 161 GGVVdLSNLERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTD 210
Cdd:PRK03858 156 DGLL-VVPPDRELAFLHPLPVRRLWGVGPVTAAKLRAHGITTVGDVAELP 204
|
|
| IMS_C |
pfam11799 |
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss). |
244-354 |
9.65e-23 |
|
impB/mucB/samB family C-terminal domain; These proteins are involved in UV protection (Swiss).
Pssm-ID: 463354 [Multi-domain] Cd Length: 104 Bit Score: 92.24 E-value: 9.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 244 KQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAlnepyyGNSASVKLLTPTQDSRDII 323
Cdd:pfam11799 1 RKSIGAERTFGRDLTDLEELREALLELAEELAERLRRQGLVARTVTVKIRYSDFR------TITRSVTLPSPTDDTDEIY 74
|
90 100 110
....*....|....*....|....*....|.
gi 446379777 324 NAATRSLDAIWQaGHRYQKAGVMLGDFFSQG 354
Cdd:pfam11799 75 RAALRLLRRLYR-GRPVRLLGVSLSNLVPEG 104
|
|
| PRK02794 |
PRK02794 |
DNA polymerase IV; Provisional |
5-389 |
1.13e-22 |
|
DNA polymerase IV; Provisional
Pssm-ID: 179473 [Multi-domain] Cd Length: 419 Bit Score: 99.24 E-value: 1.13e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 5 CDvnAFYASCETVFRPDLWGKPVVVLSNNDG-----CVIARNAeakalGVKMGDPWFKQKDLfrrC--GVVcFSSNYELY 77
Cdd:PRK02794 43 CD--AFYASVEKRDNPELRDKPVIIGGGKRGvvstaCYIARIH-----GVRSAMPMFKALKL---CpdAVV-IKPDMEKY 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 78 ADMSNRVMSTLEELSPRVEIYSIDEAFCDLTGVRN------CRDLTDFGREIRATVlqrtHLTVGVGIAQTKTLAKLAnh 151
Cdd:PRK02794 112 VRVGREVRAMMQALTPLVEPLSIDEAFLDLSGTERlhgappAVVLARFARRVEREI----GITVSVGLSYNKFLAKIA-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 152 aakkwqrqtggvvdlSNLERQRKLmSALSVDE------------VWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFN 219
Cdd:PRK02794 186 ---------------SDLDKPRGF-SVIGRAEalaflapkpvgiIWGVGPATAARLARDGIRTIGDLQRADEADLMRRFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 220 VVLERTVRELRGEPCLQLEEFAPTKQeIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPFAL 299
Cdd:PRK02794 250 SMGLRLWRLARGIDDRKVSPDREAKS-VSAETTFETDLSDFEDLEPILWRLSEKVSRRLKAAGLAGRTVTLKLKTADFRL 328
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 300 nepyygNSASVKLLTPTQdSRDIINAATRSLDAIWQAGHRYQKAGVMLGDFFSQGVAQL-NLFDDNAPRPGSEQlmAVMD 378
Cdd:PRK02794 329 ------RTRRRTLEDPTQ-LADRIFRTARELLEKETDGTAFRLIGIGVSDLSPADEADPpDLLDPQATRRAAAE--RAID 399
|
410
....*....|.
gi 446379777 379 TLNAKEGRGTL 389
Cdd:PRK02794 400 ALRAKFGAAAV 410
|
|
| PRK02406 |
PRK02406 |
DNA polymerase IV; Validated |
5-218 |
2.68e-22 |
|
DNA polymerase IV; Validated
Pssm-ID: 235035 [Multi-domain] Cd Length: 343 Bit Score: 97.11 E-value: 2.68e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 5 CDvnAFYASCETVFRPDLWGKPVVVLSNND--GCVIARNAEAKALGVKMGDPwfkQKDLFRRC--GVVCfSSNYELYADM 80
Cdd:PRK02406 1 MD--CFYAAVEMRDNPELRGKPVAVGGSPGrrGVISTCNYEARKFGVRSAMP---TAQALKLCpdLIFV-PGRFDVYKEV 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 81 SNRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCRDL-TDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANhaakKWQR- 158
Cdd:PRK02406 75 SRQIREIFRRYTDLIEPLSLDEAYLDVTDNKLCIGSaTLIAQEIRQDIFEELGLTASAGVAPNKFLAKIAS----DWNKp 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446379777 159 --QTggVVDLSNLErqrKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHF 218
Cdd:PRK02406 151 ngLF--VITPEEVD---AFLATLPVEKIPGVGKVTAEKLHALGIYTCADLQKYDLAELIRHF 207
|
|
| PolY_Rev1 |
cd01701 |
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. ... |
6-330 |
2.62e-21 |
|
DNA polymerase Rev1; Rev1 is a translesion synthesis (TLS) polymerase found in eukaryotes. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Rev1 has both structural and enzymatic roles. Structurally, it is believed to interact with other nonclassical polymerases and replication machinery to act as a scaffold. Enzymatically, it catalyzes the specific insertion of dCMP opposite abasic sites. Rev1 interacts with the Rev7 subunit of the B-family TLS polymerase Pol zeta (Rev3/Rev7). Rev1 is known to actively promote the introduction of mutations, potentially making it a significant target for cancer treatment.
Pssm-ID: 176455 [Multi-domain] Cd Length: 404 Bit Score: 95.07 E-value: 2.62e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVLSN-NDGCVIAR-NAEAKALGVKMGdPWFKQ-KDLfrrCG-VVCFSSNYELYADMS 81
Cdd:cd01701 53 DFDCFFVSVSIRNRPDLKGKPVAVCHGkGPNSEIAScNYEARSYGIKNG-MWVGQaKKL---CPqLVTLPYDFEAYEEVS 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 82 NRVMSTLEELSPRVEIYSIDEAFCDLTGVRNCR--DLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrq 159
Cdd:cd01701 129 LTFYEILASYTDNIEAVSCDEALIDITSLLEETyeLPEELAEAIRNEIRETTGCSASVGIGPNILLARLATRKAKP---- 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 160 tGGV--VDLSNLERQrklMSALSVDEVWGIGRRNSKKLDAMGIKT--VLDLADTDIRFIRKHFNVVL-ERTVRELRGEPC 234
Cdd:cd01701 205 -DGQyhLSAEKVEEF---LSQLKVGDLPGVGSSLAEKLVKLFGDTcgGLELRSKTKEKLQKVLGPKTgEKLYDYCRGIDD 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 235 LQLEEFAPtKQEIICSRSFGERITDYTSMRQAICSYAARAAEKLRSEHQYCRFIS-TFIKTSPFALNEP--YYGN----- 306
Cdd:cd01701 281 RPVTGEKE-RKSVSAEINYGIRFTNVDDVEQFLQRLSEELSKRLEESNVTGRQITlKLMKRAPGAPIEPpkYMGHgicds 359
|
330 340
....*....|....*....|....*
gi 446379777 307 -SASVKLLTPTQDSRdIINAATRSL 330
Cdd:cd01701 360 fSKSSTLGVATDDSG-VIGTEAKKL 383
|
|
| DUF4113 |
pfam13438 |
Domain of unknown function (DUF4113); Although the function is not known this domain occurs ... |
373-421 |
5.98e-21 |
|
Domain of unknown function (DUF4113); Although the function is not known this domain occurs almost invariably at the very C-terminus of the IMS family DNA-polymerase repair proteins, IMS, pfam00817.
Pssm-ID: 463876 [Multi-domain] Cd Length: 49 Bit Score: 85.23 E-value: 5.98e-21
10 20 30 40
....*....|....*....|....*....|....*....|....*....
gi 446379777 373 LMAVMDTLNAKEGRGTLYFAGQGIQQQWQMKRAMLSPRYTTRSSDLLRV 421
Cdd:pfam13438 1 LMAALDAINRRYGRGTVRLAAQGLKRDWKMRREHLSPRYTTRWDELPVV 49
|
|
| PolY_Pol_eta |
cd01702 |
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. ... |
3-337 |
1.62e-18 |
|
DNA Polymerase eta; Pol eta, also called Rad30A, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Unlike other Y-family members, Pol eta can efficiently and accurately replicate DNA past UV-induced lesions. Its activity is initiated by two simultaneous interactions: the PIP box in pol eta interacting with PCNA, and the UBZ (ubiquitin-binding zinc finger) in pol eta interacting with monoubiquitin attached to PCNA. Pol eta is more efficient in copying damaged DNA than undamaged DNA and seems to recognize when a lesion has been passed, facilitating a lesion-dependent dissociation from the DNA.
Pssm-ID: 176456 [Multi-domain] Cd Length: 359 Bit Score: 86.21 E-value: 1.62e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 3 ALCDVNAFYASCETVFRPDLWGKPVVVLSNNDgcVIARNAEAKALGVKMGD-----------------PWFKQKDLFRRC 65
Cdd:cd01702 1 AHIDMDAFFAQVEQVRLGLLRNDPVAVVQWNS--IIAVSYAARAFGVTRFMtideakkkcpdlilahvATYKKGEDEADY 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 66 GVVCFSSNY----ELYADMSNRVMSTLEELSPRVEIYSIDEAFCDLtGVRNCRdltdfgrEIRATVLQRTHLTVGVGIAQ 141
Cdd:cd01702 79 HENPSPARHkvslDPYRRASRKILNILKRFGDVVEKASIDEAYLDL-GSRIVE-------EIRQQVYDELGYTCSAGIAH 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 142 TKTLAKLANhAAKKWQRQTggVVDLSNLErqrKLMSALSVDEVWGIGRRNSKKL-DAMGIKTVLDLADTDIR--FIRKHF 218
Cdd:cd01702 151 NKMLAKLAS-GMNKPNAQT--ILRNDAVA---SFLSSLPITSIRGLGGKLGEEIiDLLGLPTEGDVAGFRSSesDLQEHF 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 219 NVVLERTV-RELRGEPCLQLEEfAPTKQEIICSRSFGERITDYTSMRQA-ICSYAARAAEKLRS-EHQYCRFISTF-IKT 294
Cdd:cd01702 225 GEKLGEWLyNLLRGIDHEPVKP-RPLPKSMGSSKNFPGKTALSTEDVQHwLLVLASELNSRLEDdRYENNRRPKTLvLSL 303
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 446379777 295 SPFALNEPYygnSASVKLltPTQDSRDIINAATRSLDAIWQAG 337
Cdd:cd01702 304 RQRGDGVRR---SRSCAL--PRYDAQKIVKDAFKLIKAINEEG 341
|
|
| PolY_Pol_iota |
cd01703 |
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. ... |
6-224 |
6.36e-15 |
|
DNA Polymerase iota; Pol iota, also called Rad30B, is a translesion synthesis (TLS) polymerase. Translesion synthesis is a process that allows the bypass of a variety of DNA lesions. TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. Pol iota is thought to be one of the least efficient polymerases, particularly when opposite pyrimidines; it can incorporate the correct nucleotide opposite a purine much more efficiently than opposite a pyrimidine, and prefers to insert guanosine instead of adenosine opposite thymidine. Pol iota is believed to use Hoogsteen rather than Watson-Crick base pairing, which may explain the varying efficiency for different template nucleotides.
Pssm-ID: 176457 [Multi-domain] Cd Length: 379 Bit Score: 75.97 E-value: 6.36e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVLSNNdgCVIARNAEAKALGVKMGDpwfKQKDLFRRCGVVCFSSNYEL--YADMSNR 83
Cdd:cd01703 4 DLDCFYAQVEEIRDPSLKSKPLGIQQKY--IVVTCNYEARRLGVKKLM---SIKDAKEICPDLVLVNGEDLtpFRDMSKK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 84 VMSTLEELSP--RVEIYSIDEAFCDLTGVRncrdL---TDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKWQR 158
Cdd:cd01703 79 VYRLLRSYSWndRVERLGFDENFMDVTEMR----LlvaSHIAYEMRERIENELGLTCCAGIASNKLLAKLVGSVNKPNQQ 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446379777 159 QTggVVDLSNlERQRKLMSALSVDEVWGIGRRNSKKLDAMGIKTVLDLA--DTDIRFIRKHFNVVLER 224
Cdd:cd01703 155 TT--LLPPSC-ADLMDFMDLHDLRKIPGIGYKTAAKLEAHGISSVRDLQefSNRNRQTVGAAPSLLEL 219
|
|
| PTZ00205 |
PTZ00205 |
DNA polymerase kappa; Provisional |
6-297 |
2.78e-09 |
|
DNA polymerase kappa; Provisional
Pssm-ID: 140232 [Multi-domain] Cd Length: 571 Bit Score: 58.88 E-value: 2.78e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 6 DVNAFYASCETVFRPDLWGKPVVVLSNNdgCVIARNAEAKALGVKMGDPWFKQkdlFRRC-GVVCFSSNYELYADMSNRV 84
Cdd:PTZ00205 139 DMDMFYAAVEIKKHPEYAAIPLAIGTMT--MLQTANYVARGRGIRQGMPGFLA---LKICpNLLILPPDFDAYNEESNTV 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 85 MSTLEELSPRVEIYSIDEAFCDLTG----VRNCRDLTDFGREIRATVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqt 160
Cdd:PTZ00205 214 RRIVAEYDPNYISFGLDELTLEVSAyierFEGTKTAEDVASELRVRVFGETKLTASAGIGPTAALAKIASNINKP----- 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 161 GGVVDLsNLERQRKLMS---ALSVDEVWGIGRRNSKKLDAMGIKTVLDLADTDIRFIRkhfnVVLERTVRELRGEP--CL 235
Cdd:PTZ00205 289 NGQHDL-NLHTRGDVMTyvrDLGLRSVPGVGKVTEALLKGLGITTLSDIYNRRVELCY----ILHNNLFRFLLGASigIM 363
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446379777 236 QLEEFAPT-------------KQEIICSRSFgERITDYTSMRQAICSYAARAAEKLRSEHQYCRFISTFIKTSPF 297
Cdd:PTZ00205 364 QWPDAATAantencegatggqRKAISSERSF-TTPRTKEGLQEMVDTVFNGAYEEMRKSELMCRQISLTIRWASY 437
|
|
| PolY_like |
cd03468 |
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that ... |
19-259 |
1.41e-08 |
|
DNA Polymerase Y-family; Y-family DNA polymerases are a specialized subset of polymerases that facilitate translesion synthesis (TLS), a process that allows the bypass of a variety of DNA lesions. Unlike replicative polymerases, TLS polymerases lack proofreading activity and have low fidelity and low processivity. They use damaged DNA as templates and insert nucleotides opposite the lesions. The active sites of TLS polymerases are large and flexible to allow the accomodation of distorted bases. Expression of Y-family polymerases is often induced by DNA damage and is believed to be highly regulated. TLS is likely induced by the monoubiquitination of the replication clamp PCNA, which provides a scaffold for TLS polymerases to bind in order to access the lesion. Because of their high error rates, TLS polymerases are potential targets for cancer treatment and prevention.
Pssm-ID: 176458 [Multi-domain] Cd Length: 335 Bit Score: 56.24 E-value: 1.41e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 19 RPDLWGKPVVVLS-NNDGCVIARNAEAKALGVKMGdpwFKQKDLFRRC-GVVCFSSNYELYADMSNRVMSTLEELSPRVE 96
Cdd:cd03468 17 RPADDEAPLAVVErKKAGRILACNAAARAAGVRPG---MPLAEALALCpNLQVVEYDPEADARALQELALWLLRFTPLVA 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 97 IYSIDEAFCDLTGVrncrdLTDFGREIRA-----TVLQRTHLTVGVGIAQTKTLAKLANHAAKKwqrqtGGVVDLSNLER 171
Cdd:cd03468 94 LDGPDGLLLDVTGC-----LHLFGGEDALaaslrAALATLGLSARAGIADTPGAAWLLARAGGG-----RGVLRREALAA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379777 172 QRKLMSALSVDEVwGIGRRNSKKLDAMGIKTVLDLADTDIRFIRKHFNVVLERTVRELRG---EPclqLEEFAPTKQEII 248
Cdd:cd03468 164 ALVLLAPLPVAAL-RLPPETVELLARLGLRTLGDLAALPRAELARRFGLALLLRLDQAYGrdpEP---LLFSPPPPAFDF 239
|
250
....*....|..
gi 446379777 249 CSRS-FGERITD 259
Cdd:cd03468 240 RLELqLEEPIAR 251
|
|
| IMS_HHH |
pfam11798 |
IMS family HHH motif; These proteins are involved in UV protection, eg. |
170-200 |
6.40e-04 |
|
IMS family HHH motif; These proteins are involved in UV protection, eg.
Pssm-ID: 432081 [Multi-domain] Cd Length: 32 Bit Score: 36.99 E-value: 6.40e-04
10 20 30
....*....|....*....|....*....|.
gi 446379777 170 ERQRKLMSALSVDEVWGIGRRNSKKLDAMGI 200
Cdd:pfam11798 2 DDVPEFLWPLPISKIPGIGKKLAEKLKALGI 32
|
|
| |
