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Conserved domains on  [gi|446379278|ref|WP_000457133|]
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MULTISPECIES: class II fructose-bisphosphate aldolase [Escherichia]

Protein Classification

class II fructose-bisphosphate aldolase( domain architecture ID 10097223)

Class II fructose-1,6-bisphosphate (FBP) aldolase catalyzes the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate.

CATH:  3.20.20.70
EC:  4.1.2.13
Gene Ontology:  GO:0004332|GO:0006096|GO:0008270|GO:0030388
PubMed:  12206759|1412694|2199259
SCOP:  4003234

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-281 1.02e-107

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


:

Pssm-ID: 238477  Cd Length: 276  Bit Score: 313.31  E-value: 1.02e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGK 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  85 NPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANADLMTQPTDVETFIAQ 164
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEED-GVVGDEGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 165 TGIDLLAVSVGTAHGMYaPGVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERGKSALL 244
Cdd:cd00947  160 TGVDALAVAIGTSHGAY-KGGEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALR 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446379278 245 HTLCHD-ISIELVDALKAMELAFEEAITPYLQASGSIG 281
Cdd:cd00947  239 EYLAENpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
 
Name Accession Description Interval E-value
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-281 1.02e-107

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 313.31  E-value: 1.02e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGK 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  85 NPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANADLMTQPTDVETFIAQ 164
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEED-GVVGDEGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 165 TGIDLLAVSVGTAHGMYaPGVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERGKSALL 244
Cdd:cd00947  160 TGVDALAVAIGTSHGAY-KGGEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALR 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446379278 245 HTLCHD-ISIELVDALKAMELAFEEAITPYLQASGSIG 281
Cdd:cd00947  239 EYLAENpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-283 3.91e-95

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 281.59  E-value: 3.91e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLAL 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  81 DHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRY-DQAANADLMTQPTDVE 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGvDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 160 TFIAQTGIDLLAVSVGTAHGMYApgVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERG 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYK--GEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAF 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446379278 240 KSALLHTLC-HDISIELVDALKAMELAFEEAITPYLQASGSIGKA 283
Cdd:COG0191  239 TAAVREYLAeNPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-282 2.44e-90

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 269.28  E-value: 2.44e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    4 DMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHF--PAPVAAAVVKTLAESASVPVTLALD 81
Cdd:pfam01116   2 NLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYagGAEALAALVRAAAEAAGVPVALHLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   82 HGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANADLMTQPTDVETF 161
Cdd:pfam01116  82 HGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEED-GVVVDEKLYTDPEEAAEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  162 IAQTGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERGKS 241
Cdd:pfam01116 161 VEATGVDALAVAIGNVHGVYKPG--PKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 446379278  242 ALLHtlcHDISIELVDALKAMELAFEEAITPYLQASGSIGK 282
Cdd:pfam01116 239 AVRE---YPPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-231 5.22e-65

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 205.24  E-value: 5.22e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQG---HLAHFPAPVAAAVVKTLAESASVPVT 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGaakYIAGLGAISAMVKAMSEAYPYGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   78 LALDHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRYDQAANAD-LMTQPT 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESaLYTDPE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446379278  157 DVETFIAQTGIDLLAVSVGTAHGMYAPGVVpAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPK-GLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNI 235
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-237 2.82e-61

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 195.33  E-value: 2.82e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLAL 80
Cdd:PRK12857   2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  81 DHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPryDQAANAD---LMTQPTD 157
Cdd:PRK12857  82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTE--DDITVDEreaAMTDPEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 158 VETFIAQTGIDLLAVSVGTAHGMYAPgvVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFE 237
Cdd:PRK12857 160 ARRFVEETGVDALAIAIGTAHGPYKG--EPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIRE 237
 
Name Accession Description Interval E-value
TBP_aldolase_IIB cd00947
Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase ...
 5-281 1.02e-107

Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238477  Cd Length: 276  Bit Score: 313.31  E-value: 1.02e-107
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGK 84
Cdd:cd00947    1 TKELLKKAREGGYAVGAFNINNLETLKAILEAAEETRSPVILQISEGAIKYAGLELLVAMVKAAAERASVPVALHLDHGS 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  85 NPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANADLMTQPTDVETFIAQ 164
Cdd:cd00947   81 SFELIKRAIRAGFSSVMIDGSHLPFEENVAKTKEVVELAHAYGVSVEAELGRIGGEED-GVVGDEGLLTDPEEAEEFVEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 165 TGIDLLAVSVGTAHGMYaPGVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERGKSALL 244
Cdd:cd00947  160 TGVDALAVAIGTSHGAY-KGGEPKLDFDRLKEIAERVNVPLVLHGGSGIPDEQIRKAIKLGVCKININTDLRLAFTAALR 238

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446379278 245 HTLCHD-ISIELVDALKAMELAFEEAITPYLQASGSIG 281
Cdd:cd00947  239 EYLAENpKEFDPRKYLAPAIEAVKEVVKHKMELFGSAG 276
Fba COG0191
Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose ...
 1-283 3.91e-95

Fructose/tagatose bisphosphate aldolase [Carbohydrate transport and metabolism]; Fructose/tagatose bisphosphate aldolase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439961  Cd Length: 283  Bit Score: 281.59  E-value: 3.91e-95
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLAL 80
Cdd:COG0191    1 MLVSLKELLDKAKEGGYAVPAFNVNNLETLQAILEAAEELNSPVILQVSEGAAKYAGLEYLAAMVRAAAEEASVPVALHL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  81 DHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRY-DQAANADLMTQPTDVE 159
Cdd:COG0191   81 DHGASFELIKRAIDAGFTSVMIDGSHLPFEENIAITKEVVEYAHAAGVSVEAELGVVGGEEDGvDVDDAEALYTDPEEAA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 160 TFIAQTGIDLLAVSVGTAHGMYApgVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERG 239
Cdd:COG0191  161 EFVEETGVDALAVAIGTVHGVYK--GEPKLDFDRLKEIREAVPVPLVLHGGSGVPDEEIREAIKLGVAKINIDTDLRLAF 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*
gi 446379278 240 KSALLHTLC-HDISIELVDALKAMELAFEEAITPYLQASGSIGKA 283
Cdd:COG0191  239 TAAVREYLAeNPDKYDPRKYLKPAREAMKEVVKEKIRLFGSAGKA 283
F_bP_aldolase pfam01116
Fructose-bisphosphate aldolase class-II;
4-282 2.44e-90

Fructose-bisphosphate aldolase class-II;


Pssm-ID: 460071  Cd Length: 276  Bit Score: 269.28  E-value: 2.44e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    4 DMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHF--PAPVAAAVVKTLAESASVPVTLALD 81
Cdd:pfam01116   2 NLKELLKKAKEGGYAVPAFNVNNLETVQAILEAAEEAKSPVILQVSPGAAAKYagGAEALAALVRAAAEAAGVPVALHLD 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   82 HGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANADLMTQPTDVETF 161
Cdd:pfam01116  82 HGASFELIKEAIEAGFTSVMIDGSHLPFEENIAITKEVVEYAHARGVSVEAELGRIGGEED-GVVVDEKLYTDPEEAAEF 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  162 IAQTGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFERGKS 241
Cdd:pfam01116 161 VEATGVDALAVAIGNVHGVYKPG--PKLDFDRLKEIQEAVPVPLVLHGGSGVPDEDIRKAIKLGVCKINIDTDLQLAFTA 238

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|.
gi 446379278  242 ALLHtlcHDISIELVDALKAMELAFEEAITPYLQASGSIGK 282
Cdd:pfam01116 239 AVRE---YPPNKDPRKYLRPAEEAMKEVVKEKIRLFGSAGK 276
cbbA TIGR00167
ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model ...
 1-231 5.22e-65

ketose-bisphosphate aldolase; This model is under revision. Proteins found by this model include fructose-bisphosphate and tagatose-bisphosphate aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 272938  Cd Length: 288  Bit Score: 205.24  E-value: 5.22e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQG---HLAHFPAPVAAAVVKTLAESASVPVT 77
Cdd:TIGR00167   2 MLVDVKELLQDAKEEGYAIPAFNINNLETINAVLEAAAEEKSPVIIQFSNGaakYIAGLGAISAMVKAMSEAYPYGVPVA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   78 LALDHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRYDQAANAD-LMTQPT 156
Cdd:TIGR00167  82 LHLDHGASEEDCAQAVKAGFSSVMIDGSHEPFEENIELTKKVVERAHKMGVSVEAELGTLGGEEDGVSVADESaLYTDPE 161

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446379278  157 DVETFIAQTGIDLLAVSVGTAHGMYAPGVVpAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:TIGR00167 162 EAKEFVKLTGVDSLAAAIGNVHGVYKGEPK-GLDFERLEEIQKYVNLPLVLHGGSGIPDEEIKKAISLGVVKVNI 235
fruc_bis_ald_ TIGR01859
fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; ...
 2-231 9.54e-65

fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist; This model represents of one of several subtypes of the class II fructose-1,6-bisphosphate aldolase, an enzyme of glycolysis. The subtypes are split into several models to allow separation of a family of tagatose bisphosphate aldolases. This form is found in Gram-positive bacteria, a variety of Gram-negative, and in amitochondriate protists. The class II enzymes share homology with tagatose bisphosphate aldolase but not with class I aldolase. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 130918  Cd Length: 282  Bit Score: 204.13  E-value: 9.54e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    2 FADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHF-PAPVAAAVVKTLAESAS-VPVTLA 79
Cdd:TIGR01859   1 LVNGKEILQKAKKEGYAVGAFNFNNLEWTQAILEAAEEENSPVIIQVSEGAIKYMgGYKMAVAMVKTLIERMSiVPVALH 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   80 LDHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRYDQAANADLmTQPTDVE 159
Cdd:TIGR01859  81 LDHGSSYESCIKAIKAGFSSVMIDGSHLPFEENLALTKKVVEIAHAKGVSVEAELGTLGGIEDGVDEKEAEL-ADPDEAE 159

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446379278  160 TFIAQTGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:TIGR01859 160 QFVKETGVDYLAAAIGTSHGKYKGE--PGLDFERLKEIKELTNIPLVLHGASGIPEEQIKKAIKLGIAKINI 229
PRK12857 PRK12857
class II fructose-1,6-bisphosphate aldolase;
1-237 2.82e-61

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 237235  Cd Length: 284  Bit Score: 195.33  E-value: 2.82e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLAL 80
Cdd:PRK12857   2 MLVTVAELLKKAEKGGYAVGAFNCNNMEIVQAIVAAAEAEKSPVIIQASQGAIKYAGIEYISAMVRTAAEKASVPVALHL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  81 DHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPryDQAANAD---LMTQPTD 157
Cdd:PRK12857  82 DHGTDFEQVMKCIRNGFTSVMIDGSKLPLEENIALTKKVVEIAHAVGVSVEAELGKIGGTE--DDITVDEreaAMTDPEE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 158 VETFIAQTGIDLLAVSVGTAHGMYAPgvVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIFE 237
Cdd:PRK12857 160 ARRFVEETGVDALAIAIGTAHGPYKG--EPKLDFDRLAKIKELVNIPIVLHGSSGVPDEAIRKAISLGVRKVNIDTNIRE 237
gatY PRK12737
tagatose-bisphosphate aldolase subunit GatY;
6-231 1.40e-58

tagatose-bisphosphate aldolase subunit GatY;


Pssm-ID: 183710  Cd Length: 284  Bit Score: 188.36  E-value: 1.40e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGKN 85
Cdd:PRK12737   7 KNMLKKAQAEGYAVPAFNIHNLETLQVVVETAAELRSPVILAGTPGTFSYAGTDYIVAIAEVAARKYNIPLALHLDHHED 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  86 PDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLA---DAPRYDQaaNADLMTQPTDVETFI 162
Cdd:PRK12737  87 LDDIKKKVRAGIRSVMIDGSHLSFEENIAIVKEVVEFCHRYDASVEAELGRLGgqeDDLVVDE--KDAMYTNPDAAAEFV 164

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446379278 163 AQTGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:PRK12737 165 ERTGIDSLAVAIGTAHGLYKGE--PKLDFERLAEIREKVSIPLVLHGASGVPDEDVKKAISLGICKVNV 231
PRK06806 PRK06806
class II aldolase;
4-236 6.26e-57

class II aldolase;


Pssm-ID: 180705  Cd Length: 281  Bit Score: 184.19  E-value: 6.26e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   4 DMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHG 83
Cdd:PRK06806   5 QMKELLKKANQENYGVGAFSVANMEMVMGAIKAAEELNSPIILQIAEVRLNHSPLHLIGPLMVAAAKQAKVPVAVHFDHG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  84 KNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPryDQAANADL-MTQPTDVETFI 162
Cdd:PRK06806  85 MTFEKIKEALEIGFTSVMFDGSHLPLEENIQKTKEIVELAKQYGATVEAEIGRVGGSE--DGSEDIEMlLTSTTEAKRFA 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446379278 163 AQTGIDLLAVSVGTAHGMYApgVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIF 236
Cdd:PRK06806 163 EETDVDALAVAIGNAHGMYN--GDPNLRFDRLQEINDVVHIPLVLHGGSGISPEDFKKCIQHGIRKINVATATF 234
gatY PRK09195
tagatose-bisphosphate aldolase; Reviewed
 6-283 1.39e-56

tagatose-bisphosphate aldolase; Reviewed


Pssm-ID: 181690  Cd Length: 284  Bit Score: 183.40  E-value: 1.39e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGKN 85
Cdd:PRK09195   7 KQMLNNAQRGGYAVPAFNIHNLETMQVVVETAAELHSPVIIAGTPGTFSYAGTEYLLAIVSAAAKQYHHPLALHLDHHEK 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  86 PDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRYDQAANAD-LMTQPTDVETFIAQ 164
Cdd:PRK09195  87 FDDIAQKVRSGVRSVMIDGSHLPFAQNISLVKEVVDFCHRFDVSVEAELGRLGGQEDDLQVDEADaLYTDPAQAREFVEA 166

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 165 TGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAI---FERG-K 240
Cdd:PRK09195 167 TGIDSLAVAIGTAHGMYKGE--PKLDFDRLENIRQWVNIPLVLHGASGLPTKDIQQTIKLGICKVNVATELkiaFSQAlK 244

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446379278 241 SALL-HTLCHDISIELVDALKAMELAFEEAItpylQASGSIGKA 283
Cdd:PRK09195 245 NYLTeHPEANDPRHYLQPAKSAMKDVVSKVI----ADCGCEGKA 284
PRK06801 PRK06801
ketose 1,6-bisphosphate aldolase;
5-283 2.16e-53

ketose 1,6-bisphosphate aldolase;


Pssm-ID: 180701  Cd Length: 286  Bit Score: 175.32  E-value: 2.16e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGK 84
Cdd:PRK06801   6 LANGLAHARKHGYALGAFNVLDSHFLRALFAAAKQERSPFIINIAEVHFKYISLESLVEAVKFEAARHDIPVVLNLDHGL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  85 NPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLA--DAPRYDQAANADLMTQPTDVETFI 162
Cdd:PRK06801  86 HFEAVVRALRLGFSSVMFDGSTLEYEENVRQTREVVKMCHAVGVSVEAELGAVGgdEGGALYGEADSAKFTDPQLARDFV 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 163 AQTGIDLLAVSVGTAHGMYAPgvVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINvgaaiFERGKS- 241
Cdd:PRK06801 166 DRTGIDALAVAIGNAHGKYKG--EPKLDFARLAAIHQQTGLPLVLHGGSGISDADFRRAIELGIHKIN-----FYTGMSq 238

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 446379278 242 ALLHTLCHDISI------ELVDALKAMELAFEEAITPYLQASGSIGKA 283
Cdd:PRK06801 239 AALAAVEQRMTHrhaiydEFAELLLGIEEAISDTVAQQMRIFGSAGQA 286
PRK08185 PRK08185
hypothetical protein; Provisional
 5-231 1.70e-52

hypothetical protein; Provisional


Pssm-ID: 181275  Cd Length: 283  Bit Score: 172.99  E-value: 1.70e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAhFPAPVAAAVVKTLAESASVPVTLALDHGK 84
Cdd:PRK08185   1 MKELLKVAKEHQFAVGAFNVADSCFLRAVVEEAEANNAPAIIAIHPNELD-FLGDNFFAYVRERAKRSPVPFVIHLDHGA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  85 NPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLAD-APRYDQAANADLMTQPTDVETFIA 163
Cdd:PRK08185  80 TIEDVMRAIRCGFTSVMIDGSLLPYEENVALTKEVVELAHKVGVSVEGELGTIGNtGTSIEGGVSEIIYTDPEQAEDFVS 159

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446379278 164 QTGIDLLAVSVGTAHGMYAPGVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:PRK08185 160 RTGVDTLAVAIGTAHGIYPKDKKPELQMDLLKEINERVDIPLVLHGGSANPDAEIAESVQLGVGKINI 227
tag_bisphos_ald TIGR01858
class II aldolase, tagatose bisphosphate family; This model describes tagatose-1, ...
 6-275 6.88e-52

class II aldolase, tagatose bisphosphate family; This model describes tagatose-1,6-bisphosphate aldolases, and perhaps other closely related class II aldolases. This tetrameric, Zn2+-dependent enzyme is related to the class II fructose bisphosphate aldolase; fructose 1,6-bisphosphate and tagatose 1,6 bisphosphate differ only in chirality at C4.


Pssm-ID: 130917  Cd Length: 282  Bit Score: 171.19  E-value: 6.88e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGKN 85
Cdd:TIGR01858   5 KYMLQDAQAGGYAVPAFNIHNLETIQAVVETAAEMRSPVILAGTPGTFKHAGTEYIVALCSAASTTYNMPLALHLDHHES 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   86 PDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRYDQAANAD-LMTQPTDVETFIAQ 164
Cdd:TIGR01858  85 LDDIRQKVHAGVRSAMIDGSHFPFAQNVKLVKEVVDFCHRQDCSVEAELGRLGGVEDDLSVDEEDaLYTDPQEAKEFVEA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  165 TGIDLLAVSVGTAHGMYAPgvVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAaifergksall 244
Cdd:TIGR01858 165 TGVDSLAVAIGTAHGLYKK--TPKLDFDRLAEIREVVDVPLVLHGASDVPDEDVRRTIELGICKVNVAT----------- 231

                         250       260       270
                  ....*....|....*....|....*....|...
gi 446379278  245 htlchDISIELVDALKAMELAFEEAITP--YLQ 275
Cdd:TIGR01858 232 -----ELKIAFSGAVKAYFAENPQANDPryYMR 259
gatY PRK07998
class II aldolase;
4-233 8.34e-52

class II aldolase;


Pssm-ID: 181192  Cd Length: 283  Bit Score: 171.10  E-value: 8.34e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   4 DMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHG 83
Cdd:PRK07998   5 NGRILLDRIQEKHVLAGAFNTTNLETTISILNAIERSGLPNFIQIAPTNAQLSGYDYIYEIVKRHADKMDVPVSLHLDHG 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  84 KNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLAdAPRYDQAANADLMTQPTDVETFIA 163
Cdd:PRK07998  85 KTFEDVKQAVRAGFTSVMIDGAALPFEENIAFTKEAVDFAKSYGVPVEAELGAIL-GKEDDHVSEADCKTEPEKVKDFVE 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 164 QTGIDLLAVSVGTAHGMyapGVVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGA 233
Cdd:PRK07998 164 RTGCDMLAVSIGNVHGL---EDIPRIDIPLLKRIAEVSPVPLVIHGGSGIPPEILRSFVNYKVAKVNIAS 230
kbaY PRK12738
tagatose-bisphosphate aldolase subunit KbaY;
6-235 8.76e-48

tagatose-bisphosphate aldolase subunit KbaY;


Pssm-ID: 183711  Cd Length: 286  Bit Score: 160.97  E-value: 8.76e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAESASVPVTLALDHGKN 85
Cdd:PRK12738   7 KYLLQDAQANGYAVPAFNIHNAETIQAILEVCSEMRSPVILAGTPGTFKHIALEEIYALCSAYSTTYNMPLALHLDHHES 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  86 PDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANAD--LMTQPTDVETFIA 163
Cdd:PRK12738  87 LDDIRRKVHAGVRSAMIDGSHFPFAENVKLVKSVVDFCHSQDCSVEAELGRLGGVED-DMSVDAEsaFLTDPQEAKRFVE 165

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446379278 164 QTGIDLLAVSVGTAHGMYAPgvVPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINVGAAI 235
Cdd:PRK12738 166 LTGVDSLAVAIGTAHGLYSK--TPKIDFQRLAEIREVVDVPLVLHGASDVPDEFVRRTIELGVTKVNVATEL 235
PRK07709 PRK07709
fructose-bisphosphate aldolase; Provisional
 5-231 8.13e-46

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 169068  Cd Length: 285  Bit Score: 155.60  E-value: 8.13e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQG---HLAHFPAPVAaaVVKTLAE--SASVPVTLA 79
Cdd:PRK07709   6 MKEMLNKALEGKYAVGQFNMNNLEWTQAILAAAEEEKSPVILGVSEGaarHMTGFKTVVA--MVKALIEemNITVPVAIH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  80 LDHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLAdAPRYDQAANADLMTQPTDVE 159
Cdd:PRK07709  84 LDHGSSFEKCKEAIDAGFTSVMIDASHHPFEENVETTKKVVEYAHARNVSVEAELGTVG-GQEDDVIAEGVIYADPAECK 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446379278 160 TFIAQTGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:PRK07709 163 HLVEATGIDCLAPALGSVHGPYKGE--PNLGFAEMEQVRDFTGVPLVLHGGTGIPTADIEKAISLGTSKINV 232
PRK08610 PRK08610
fructose-bisphosphate aldolase; Reviewed
 5-231 3.66e-45

fructose-bisphosphate aldolase; Reviewed


Pssm-ID: 181501  Cd Length: 286  Bit Score: 153.99  E-value: 3.66e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   5 MKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQG---HLAHFPAPVAaaVVKTLAE--SASVPVTLA 79
Cdd:PRK08610   6 MKEMLIDAKENGYAVGQYNLNNLEFTQAILEASQEENAPVILGVSEGaarYMSGFYTVVK--MVEGLMHdlNITIPVAIH 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  80 LDHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLAdAPRYDQAANADLMTQPTDVE 159
Cdd:PRK08610  84 LDHGSSFEKCKEAIDAGFTSVMIDASHSPFEENVATTKKVVEYAHEKGVSVEAELGTVG-GQEDDVVADGIIYADPKECQ 162

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446379278 160 TFIAQTGIDLLAVSVGTAHGMYAPGvvPAIDFQRLAEISRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:PRK08610 163 ELVEKTGIDALAPALGSVHGPYKGE--PKLGFKEMEEIGLSTGLPLVLHGGTGIPTKDIQKAIPFGTAKINV 232
PRK05835 PRK05835
class II fructose-1,6-bisphosphate aldolase;
1-231 4.76e-43

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180280 [Multi-domain]  Cd Length: 307  Bit Score: 148.97  E-value: 4.76e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   1 MFADMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAES-ASVPVTLA 79
Cdd:PRK05835   1 MLVKGNEILLKAHKEGYGVGAFNFVNFEMLNAIFEAGNEENSPLFIQASEGAIKYMGIDMAVGMVKIMCERyPHIPVALH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  80 LDHGKNPDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRYDQAANAD-LMTQPTDV 158
Cdd:PRK05835  81 LDHGTTFESCEKAVKAGFTSVMIDASHHAFEENLELTSKVVKMAHNAGVSVEAELGRLMGIEDNISVDEKDaVLVNPKEA 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 159 ETFIAQTGIDLLAVSVGTAHGMYAPGVVPAIDFQRLAEISRCSSVPLALHGGS---------------------GTPFDQ 217
Cdd:PRK05835 161 EQFVKESQVDYLAPAIGTSHGAFKFKGEPKLDFERLQEVKRLTNIPLVLHGASaipddvrksyldaggdlkgskGVPFEF 240

                        250
                 ....*....|....
gi 446379278 218 LQLCTTLGVAKINV 231
Cdd:PRK05835 241 LQESVKGGINKVNT 254
PLN02858 PLN02858
fructose-bisphosphate aldolase
 6-283 2.62e-40

fructose-bisphosphate aldolase


Pssm-ID: 215463 [Multi-domain]  Cd Length: 1378  Bit Score: 148.85  E-value: 2.62e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278    6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTlAESASVPVTLALDHGKN 85
Cdd:PLN02858 1103 KELLLNAEKGGYAVGAFNVYNLEGIEAVVAAAEAEKSPAILQVHPGALKQGGIPLVSCCIAA-AEQASVPITVHFDHGTS 1181

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   86 PDCIRQAFRAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPryDQAANADLMTQPTDV---ETFI 162
Cdd:PLN02858 1182 KHELLEALELGFDSVMVDGSHLSFTENISYTKSISSLAHSKGLMVEAELGRLSGTE--DGLTVEEYEAKLTDVdqaKEFI 1259

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  163 AQTGIDLLAVSVGTAHGMYaPGVVPAIDFQRLAEISRCSS---VPLALHGGSGTPFDQLQLCTTLGVAKINVGAAIferg 239
Cdd:PLN02858 1260 DETGIDALAVCIGNVHGKY-PASGPNLRLDLLKELRALSSkkgVLLVLHGASGLPESLIKECIENGVRKFNVNTEV---- 1334

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 446379278  240 KSALLHTLCHDISIELVDALKAMELAFEEAITPYLQASGSIGKA 283
Cdd:PLN02858 1335 RTAYMEALSSPKKTDLIDVMSAAKEAMKAVVAEKLRLFGSAGKA 1378
PRK07084 PRK07084
class II fructose-1,6-bisphosphate aldolase;
6-231 2.14e-39

class II fructose-1,6-bisphosphate aldolase;


Pssm-ID: 180829  Cd Length: 321  Bit Score: 139.86  E-value: 2.14e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGH-------LAHFPAPVAAAVVKTLAesASVPVTL 78
Cdd:PRK07084  13 REMFAKAVKGGYAIPAYNFNNMEQLQAIIQACVETKSPVILQVSKGArkyanatLLRYMAQGAVEYAKELG--CPIPIVL 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  79 ALDHGKN----PDCIRqafrAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADAPRyDQAANADLMTQ 154
Cdd:PRK07084  91 HLDHGDSfelcKDCID----SGFSSVMIDGSHLPYEENVALTKKVVEYAHQFDVTVEGELGVLAGVED-EVSAEHHTYTQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 155 PTDVETFIAQTGIDLLAVSVGTAHGMY--APG-VVPAIDFQRLAEIS-RCSSVPLALHGGS------------------- 211
Cdd:PRK07084 166 PEEVEDFVKKTGVDSLAISIGTSHGAYkfKPGqCPPPLRFDILEEIEkRIPGFPIVLHGSSsvpqeyvktineyggklkd 245

                        250       260
                 ....*....|....*....|..
gi 446379278 212 --GTPFDQLQLCTTLGVAKINV 231
Cdd:PRK07084 246 aiGIPEEQLRKAAKSAVCKINI 267
FTBP_aldolase_II cd00453
Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1, ...
 6-231 8.31e-38

Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to yield fructose-1,6-bisphosphate. TBP-aldolase is tetrameric and produces tagarose-1,6-bisphosphate. There is an absolute requirement for a divalent metal ion, usually zinc, and in addition the enzymes are activated by monovalent cations such as Na+. Although structurally similar, the class I aldolases use a different mechanism and are believed to have an independent evolutionary origin.


Pssm-ID: 238255  Cd Length: 340  Bit Score: 136.09  E-value: 8.31e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   6 KSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPIILNLYQG----------------HLAHFPAPVAAAVVKTLA 69
Cdd:cd00453    2 QKVFQVAKENNFALPAVNCVGTDSINAVLETAAKVKAPVIVQFSNGgasfiagkgvksdvpqGAAILGAISGAHHVHQMA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  70 ESASVPVTLALDH--GKNPDCIRQAFRAG-----------FSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGH 136
Cdd:cd00453   82 EHYGVPVILHTDHcaKKLLPWIDGLLDAGekhfaatgkplFSSHMIDLSEESLQENIEICSKYLERMSKIGMTLEIELGC 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 137 LA---DAPRYDQAANADLMTQPTDVETFIAQTG----IDLLAVSVGTAHGMYAPGvVPAIDFQRLAEISR---------C 200
Cdd:cd00453  162 TGgeeDGVDNSHMDASALYTQPEDVDYAYTELSkispRFTIAASFGNVHGVYKKG-NVVLTPTILRDSQEyvskkhnlpH 240

                        250       260       270
                 ....*....|....*....|....*....|.
gi 446379278 201 SSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:cd00453  241 NSLNFVFHGGSGSTAQEIKDSVSYGVVKMNI 271
PRK07315 PRK07315
fructose-bisphosphate aldolase; Provisional
 17-231 4.75e-31

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 180926  Cd Length: 293  Bit Score: 117.29  E-value: 4.75e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  17 YALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPA-PVAAAVVKTLAESA--SVPVTLALDHGKNPDCIrQAF 93
Cdd:PRK07315  18 YAVGGFNTNNLEWTQAILRAAEAKKAPVLIQTSMGAAKYMGGyKVCKNLIENLVESMgiTVPVAIHLDHGHYEDAL-ECI 96

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  94 RAGFSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLADApryDQAANADLMTQPTDVETFIAQTGIDLLAVS 173
Cdd:PRK07315  97 EVGYTSIMFDGSHLPVEENLKLAKEVVEKAHAKGISVEAEVGTIGGE---EDGIIGKGELAPIEDAKAMVETGIDFLAAG 173

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446379278 174 VGTAHGMYaPGVVPAIDFQRLAEISRC-SSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:PRK07315 174 IGNIHGPY-PENWEGLDLDHLEKLTEAvPGFPIVLHGGSGIPDDQIQEAIKLGVAKVNV 231
PRK13399 PRK13399
fructose-bisphosphate aldolase class II;
15-231 4.77e-29

fructose-bisphosphate aldolase class II;


Pssm-ID: 184029  Cd Length: 347  Bit Score: 112.95  E-value: 4.77e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  15 EH-YALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAES-ASVPVTLALDHGKNPDCIRQA 92
Cdd:PRK13399  15 ENgYGVPAFNVNNMEQILAIMEAAEATDSPVILQASRGARKYAGDAMLRHMVLAAAEMyPDIPICLHQDHGNSPATCQSA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  93 FRAGFSGLMIDASAFP-------LEENVRQTRAVVELAASAQLCVEGELGHLA-----DAPRYD------QAANADLMTQ 154
Cdd:PRK13399  95 IRSGFTSVMMDGSLLAdgktpasYDYNVDVTRRVTEMAHAVGVSVEGELGCLGsletgEAGEEDgvgaegKLSHDQMLTD 174

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 155 PTDVETFIAQTGIDLLAVSVGTAHGMYA-----PGVVPAIDfqRLAEISR-----------CSSVPLAL------HGGS- 211
Cdd:PRK13399 175 PDQAVDFVQRTGVDALAIAIGTSHGAYKftrkpDGDILAID--RIEEIHArlpnthlvmhgSSSVPQELqeiinaYGGKm 252

                        250       260
                 ....*....|....*....|....
gi 446379278 212 ----GTPFDQLQLCTTLGVAKINV 231
Cdd:PRK13399 253 ketyGVPVEEIQRGIKHGVRKVNI 276
PRK09196 PRK09196
fructose-bisphosphate aldolase class II;
15-231 4.63e-26

fructose-bisphosphate aldolase class II;


Pssm-ID: 181691  Cd Length: 347  Bit Score: 105.04  E-value: 4.63e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  15 EH-YALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHLAHFPAPVAAAVVKTLAES-ASVPVTLALDHGKNPDCIRQA 92
Cdd:PRK09196  15 EHgYGVPAFNVNNLEQVQAIMEAADETDSPVILQASAGARKYAGEPFLRHLILAAVEEyPHIPVVMHQDHGNSPATCQRA 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  93 FRAGFSGLMIDASafpLEE----------NVRQTRAVVELAASAQLCVEGELG---------------HLADAP-RYDQa 146
Cdd:PRK09196  95 IQLGFTSVMMDGS---LKAdgktpasyeyNVDVTRKVVEMAHACGVSVEGELGclgsletgmggeedgHGAEGKlSHDQ- 170

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 147 anadLMTQPTDVETFIAQTGIDLLAVSVGTAHGMYA----P-GVVPAIDfqRLAEISR-----------CSSVPLAL--- 207
Cdd:PRK09196 171 ----LLTDPEEAADFVKKTQVDALAIAIGTSHGAYKftrkPtGDVLAID--RIKEIHArlpnthlvmhgSSSVPQELldi 244

                        250       260       270
                 ....*....|....*....|....*....|..
gi 446379278 208 ---HGGS-----GTPFDQLQLCTTLGVAKINV 231
Cdd:PRK09196 245 ineYGGDmpetyGVPVEEIQEGIKHGVRKVNI 276
FBP_aldolase_IIA cd00946
Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the ...
 17-231 1.65e-22

Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is homodimeric and used in gluconeogenesis and glycolysis. The type A and type B Class II FBPA's differ in the presence and absence of distinct indels in the sequence that result in differing loop lengths in the structures.


Pssm-ID: 238476  Cd Length: 345  Bit Score: 95.13  E-value: 1.65e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  17 YALLAINCMNLESAHAAIRVAEKNRAPIILNLYQGHlAHF-----------PAPVAAAV-----VKTLAESASVPVTLAL 80
Cdd:cd00946   16 FAIPAVNCTSSSTINAVLEAARDAKSPIIIQFSNGG-AAFyagkglknekqKASIAGAIaaahhVRSMAEHYGVPVVLHT 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  81 DHgknpdC-------IRQAFRAG-----------FSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELGHLA---D 139
Cdd:cd00946   95 DH-----CakkllpwFDGLLEADeeyfkqhgeplFSSHMLDLSEEPLEENIEICKKYLERMAKINMWLEMEIGITGgeeD 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 140 APRYDQAANADLMTQPTDV----ETFIAQTGIDLLAVSVGTAHGMYAPGVV---PAI-----DFQRlAEISRCSSVPLAL 207
Cdd:cd00946  170 GVDNSGVDNAELYTQPEDVwyvyEALSKISPNFSIAAAFGNVHGVYKPGNVklqPEIlgehqDYVR-EKLGLADDKPLYF 248

                        250       260
                 ....*....|....*....|....*.
gi 446379278 208 --HGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:cd00946  249 vfHGGSGSTKEEIREAISYGVVKMNI 274
PRK09197 PRK09197
fructose-bisphosphate aldolase; Provisional
 4-231 3.81e-19

fructose-bisphosphate aldolase; Provisional


Pssm-ID: 236406  Cd Length: 350  Bit Score: 85.62  E-value: 3.81e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278   4 DMKSMVMKAWHEHYALLAINCMNLESAHAAIRVAEKNRAPII---------------LNLYQGHLAHFPAPVAAAVVKTL 68
Cdd:PRK09197   8 DYQEMFDRAKENGFALPAVNVVGTDSINAVLEGAAEAKSPVIiqfsnggaafiagkgVKDDGQGAAVLGAIAGAKHVHEV 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278  69 AESASVPVTLALDH--GKNPDCIR-------QAFRAG----FSGLMIDASAFPLEENVRQTRAVVELAASAQLCVEGELG 135
Cdd:PRK09197  88 AEHYGVPVILHTDHcaKKLLPWIDglldageKHFAAGgkplFSSHMIDLSEEPLEENIEICSKYLERMAKAGMTLEIELG 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446379278 136 HLA---DAPRYDQAANADLMTQPTDV----ETFIAQTGIDLLAVSVGTAHGMYAPGVV---PAIdfqrLAEI-------- 197
Cdd:PRK09197 168 VTGgeeDGVDNSHEDNSKLYTQPEDVlyayEALGKISGRFTIAASFGNVHGVYKPGNVklrPEI----LKDSqeyvskkf 243

                        250       260       270
                 ....*....|....*....|....*....|....*
gi 446379278 198 -SRCSSVPLALHGGSGTPFDQLQLCTTLGVAKINV 231
Cdd:PRK09197 244 gLPAKPFDFVFHGGSGSTLEEIREAVSYGVVKMNI 278
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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