|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-875 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1619.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 1 MEMKPKYDPREVEAGRYEEWVKNGYFKPSEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:COG0525 1 MELPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 81 MDHAGIATQAKVEAKLNEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVD 160
Cdd:COG0525 81 TDHAGIATQAVVERQLAEEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVR 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGEGFIEIATTRPETMLGDTAIVVNPNDERYKDV 240
Cdd:COG0525 161 LYEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPLADGSGYIVVATTRPETMLGDTAVAVHPEDERYKHL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 241 IGKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDCRKQ 320
Cdd:COG0525 241 IGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENAGKYRGLDRFEARKA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 321 LVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKtDDRIDFYPQRFEHTFNQWMENIRD 400
Cdd:COG0525 321 IVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVE-DGEIKFVPERWEKTYFHWMENIRD 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 401 WTISRQLWWGHQIPAWYHKEtGEIYVGEEAPT-----DIENWQQDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYPTN 475
Cdd:COG0525 400 WCISRQLWWGHRIPAWYCPD-GEVYVARTEPEacakaGSVNLTQDEDVLDTWFSSALWPFSTLGWPE-KTEDLKYFYPTS 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 476 VLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGH 555
Cdd:COG0525 478 VLVTGFDIIFFWVARMIMMGLHFTGEVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGR 557
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 556 DLRYSTEKVESVWNFINKIWNGARFSLMNiGEDFKVEDIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALY 635
Cdd:COG0525 558 DIKFDEERVEGYRNFANKLWNASRFVLMN-LEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALY 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 636 NFIWDDFCDWYIEMSKIPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLP--HQGETIVKASWPEVRES 713
Cdd:COG0525 637 DFVWNEFCDWYLELAKPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPprKEGESIMLAPWPEADEE 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 714 LVFEESKQTMQQLVEIIKSVRQSRVEVNTPLSKEIPILIQAKDKEIETTLSQNKDYLIKFCNPSTLNISTDvEIPEKAMT 793
Cdd:COG0525 717 LIDEEAEAEFEWLKEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITILVD-EKPEGAAS 795
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 794 SVVIAGKVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQDYQEKYDGVKARIEQ 873
Cdd:COG0525 796 AVVGGAEVFLPLEGLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLAR 875
|
..
gi 446347494 874 LK 875
Cdd:COG0525 876 LK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-876 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1609.39 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 1 MEMKPKYDPREVEAGRYEEWVKNGYFKPsEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:PRK05729 3 MELPKTYDPKEVEAKWYQKWEEKGYFKP-DDNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 81 MDHAGIATQAKVEAKLNEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVD 160
Cdd:PRK05729 82 TDHAGIATQMVVERQLAAEGKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVR 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGEGFIEIATTRPETMLGDTAIVVNPNDERYKDV 240
Cdd:PRK05729 162 LYEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADGSDYLVVATTRPETMLGDTAVAVNPEDERYKHL 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 241 IGKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDCRKQ 320
Cdd:PRK05729 242 IGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINENPGEYQGLDRFEARKA 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 321 LVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKtDDRIDFYPQRFEHTFNQWMENIRD 400
Cdd:PRK05729 322 IVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVE-NGEIKFVPERWEKTYFHWMENIQD 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 401 WTISRQLWWGHQIPAWYHKEtGEIYVGEEAPTDIEN--WQQDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYPTNVLV 478
Cdd:PRK05729 401 WCISRQLWWGHRIPAWYDED-GEVYVGREEPEAREKalLTQDEDVLDTWFSSALWPFSTLGWPE-KTEDLKRFYPTSVLV 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 479 TGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLR 558
Cdd:PRK05729 479 TGFDIIFFWVARMIMMGLHFTGQVPFKDVYIHGLVRDEQGRKMSKSKGNVIDPLDLIDKYGADALRFTLAALASPGRDIR 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 559 YSTEKVESVWNFINKIWNGARFSLMNIGEDfKVEDIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFI 638
Cdd:PRK05729 559 FDEERVEGYRNFANKLWNASRFVLMNLEGA-DVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFI 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 639 WDDFCDWYIEMSKIPMNgndEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPHQG--ETIVKASWPEVRESLvF 716
Cdd:PRK05729 638 WNEFCDWYLELAKPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGieESIMLAPWPEADEAI-D 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 717 EESKQTMQQLVEIIKSVRQSRVEVNTPLSKEIPILIQAKDKEIETTLSQNKDYLIKFCNPSTLNISTDVE-IPEKAMTSV 795
Cdd:PRK05729 714 EAAEAEFEWLKELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEeAPEGAASAV 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 796 VIAGKVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQDYQEKYDGVKARIEQLK 875
Cdd:PRK05729 794 VGGAELFLPLEGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLK 873
|
.
gi 446347494 876 A 876
Cdd:PRK05729 874 A 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
3-856 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1226.07 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 3 MKPKYDPREVEAGRYEEWVKNGYFKPSEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMD 82
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 83 HAGIATQAKVEAKLNEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLY 162
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAEGKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRLY 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 163 NKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADG-EGFIEIATTRPETMLGDTAIVVNPNDERYKDVI 241
Cdd:TIGR00422 161 EKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGsKDYLVVATTRPETMFGDTAVAVHPEDERYKHLI 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 242 GKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDCRKQL 321
Cdd:TIGR00422 241 GKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENAGKYQGLTRFEARKKI 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 322 VEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKtDDRIDFYPQRFEHTFNQWMENIRDW 401
Cdd:TIGR00422 321 VEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAE-EGEIKFVPKRMEKRYLNWLRNIKDW 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 402 TISRQLWWGHQIPAWYHKETGEIYVGEEAPTDIE--------NWQQDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYP 473
Cdd:TIGR00422 400 CISRQLIWGHRIPVWYCKECGEVYVAKEEPLPDDktntgpsvELEQDTDVLDTWFSSSLWPFSTLGWPD-ETKDLKKFYP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 474 TNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSP 553
Cdd:TIGR00422 479 TDLLVTGYDIIFFWVARMIFRSLALTGQVPFKEVYIHGLVRDEQGRKMSKSLGNVIDPLDVIEKYGADALRFTLASLVTP 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 554 GHDLRYSTEKVESVWNFINKIWNGARFSLMNIGEDFKVEdiDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRA 633
Cdd:TIGR00422 559 GDDINFDWKRVESARNFLNKLWNASRFVLMNLSDDLELS--GGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKA 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 634 LYNFIWDDFCDWYIEMSKIPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPHQGETIVKASWPEVRES 713
Cdd:TIGR00422 637 LYEFIWNDFCDWYIELVKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFKEGADSIMLQSYPVVDAE 716
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 714 LVFEESKQTMQQLVEIIKSVRQSRVEVNTPLSKEIPILIQAKDKEIETTLSQNKDYLIKFCNPSTLNISTDVEIPEKAMT 793
Cdd:TIGR00422 717 FVDEEAEKAFELLKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVV 796
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446347494 794 SVVIAGKVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRK 856
Cdd:TIGR00422 797 ELVPGFEIIIPVKGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEK 859
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
2-876 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 947.89 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 2 EMKPKYDPREVEAGRYEEWVKNGYFKPSE-DKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:PRK14900 14 ELAKGYEHREVEARWYPFWQERGYFHGDEhDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 81 MDHAGIATQAKVEAKLNE-QGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFV 159
Cdd:PRK14900 94 TDHAGIATQMIVEKELKKtEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFV 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 160 DLYNKGIIYRGERIINWDPKARTALSDIEVIHEDV-QGAFYHFKYPYADGEGFIEIATTRPETMLGDTAIVVNPNDERYK 238
Cdd:PRK14900 174 RLHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAhQGELWSFAYPLADGSGEIVVATTRPETMLGDTAVAVHPLDPRYM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 239 DVIGKTVILPIVGRELPILAD-EYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDC 317
Cdd:PRK14900 254 ALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEAGPLAGLDRFEA 333
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 318 RKQLVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKtDDRIDFYPQRFEHTFNQWMEN 397
Cdd:PRK14900 334 RKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAVE-QGRTRFIPEQWTNTYMAWMRN 412
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 398 IRDWTISRQLWWGHQIPAWYHKEtGEIYVGEEAPTDIE-----NWQQDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYY 472
Cdd:PRK14900 413 IHDWCISRQLWWGHQIPAWYCPD-GHVTVARETPEACStcgkaELRQDEDVLDTWFSSGLWPFSTMGWPE-QTDTLRTFY 490
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 473 PTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSS 552
Cdd:PRK14900 491 PTSVMETGHDIIFFWVARMMMMGLHFMGEVPFRTVYLHPMVRDEKGQKMSKTKGNVIDPLVITEQYGADALRFTLAALTA 570
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 553 PGHDLRYSTEKVESVWNFINKIWNGARFSLMNIGEdFKVEDIDLS-GNLSLADKWILTRLNETIATVTDLSDKYEFGEVG 631
Cdd:PRK14900 571 QGRDIKLAKERIEGYRAFANKLWNASRFALMNLSG-YQERGEDPArLARTPADRWILARLQRAVNETVEALEAFRFNDAA 649
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 632 RALYNFIWDDFCDWYIEMSKIPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPHQ------GETIVKA 705
Cdd:PRK14900 650 NAVYAFVWHELCDWYIELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHVLRAQvgasawADSVLAA 729
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 706 SWPEVREslVFEESKQTMQQLVEIIKSVRQSRVEVNTP----LSKEIPILIQAKDKEIETTLSQN-KDYLIKFCNPSTLN 780
Cdd:PRK14900 730 EYPRKGE--ADEAAEAAFRPVLGIIDAVRNIRGEMGIPwkvkLGAQAPVEIAVADPALRDLLQAGeLARVHRVAGVEGSR 807
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 781 IsTDVEIPEKAMTSVVIAG---KVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKK 857
Cdd:PRK14900 808 L-VVAAATAPAPQSAVGVGpgfEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARA 886
|
890
....*....|....*....
gi 446347494 858 QDYQEKydgvKARIEQLKA 876
Cdd:PRK14900 887 EELREK----RGKLEAHRA 901
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
2-875 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 942.13 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 2 EMKPKYDPREVEAGRYEEWVKNGYFKPSED----KSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLY 77
Cdd:PTZ00419 23 SMAASYDPKEVESGWYEWWEKSGFFKPAEDakslNSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 78 LPGMDHAGIATQAKVEAKL-NEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKK 156
Cdd:PTZ00419 103 VPGTDHAGIATQVVVEKKLmKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKE 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 157 VFVDLYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQ----------------GAFYHFKYPYAD-GEGFIEIATTRP 219
Cdd:PTZ00419 183 AFVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYPLEDsGQEEIVVATTRI 262
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 220 ETMLGDTAIVVNPNDERYKDVIGKTVILP-IVGRELPILADE-YVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMD 297
Cdd:PTZ00419 263 ETMLGDVAVAVHPKDERYKKLHGKELIHPfIPDRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFINIFT 342
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 298 ENGKMNDKAGKYEGMDRFDCRKQLVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKTD 377
Cdd:PTZ00419 343 LDGKINENGGEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPMLIPQWYVNCKDMAKRAVEAVRNG 422
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 378 DrIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPAWyhKETGEiyVGEEAPTDIENW-------------------- 437
Cdd:PTZ00419 423 E-LKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAY--RVISK--GPETDPSDEEPWvvarseeealekakkkfgls 497
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 438 ------QQDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHG 511
Cdd:PTZ00419 498 eedfelEQDEDVLDTWFSSGLFPFSTLGWPD-QTDDLQRFFPTSLLETGSDILFFWVARMVMMSLHLTDKLPFKTVFLHA 576
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 512 LVRAEDGRKMSKSLGNGVDPMDVID-------------------------------------EYGADSLRYFLATGSSPG 554
Cdd:PTZ00419 577 MVRDSQGEKMSKSKGNVIDPLEVIEgislqdlnqklyegnlpekeikraielqkkefpngipECGTDALRFGLLAYTQQG 656
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 555 HDLRYSTEKVESVWNFINKIWNGARFSLMNIGEDFKVEDIDLSGN-----LSLADKWILTRLNETIATVTDLSDKYEFGE 629
Cdd:PTZ00419 657 RNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFNLPNSTLFKPnnvesLPWEDKWILHRLNVAIKEVTEGFKEYDFSE 736
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 630 VGRALYNFIWDDFCDWYIEMSK-IPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLP---HQGETIVKA 705
Cdd:PTZ00419 737 ATQATYNFWLYELCDVYLELIKpRLSKQSDGERKQHAQDVLHTVLDIGLRLLHPMMPFITEELYQRLPnylRKSESISIA 816
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 706 SWPEVRESLVFEESKQTMQQLVEIIKSVRQSRVEVNTPLSKEIPILIQAKDKEIETTLSQNKDYLIKFCNPSTLNISTDV 785
Cdd:PTZ00419 817 KYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKDAELIELIESAENLISTLAKIGSVSVIPPI 896
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 786 ----EIPEKAMTSVVIaGKVV--LPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQD 859
Cdd:PTZ00419 897 eeeaEVPKGCGFDVVD-NKVIiyLNLDEFIDLKKELAKLEKKLAKLQKSLESYLKKISIPNYEDKVPEDVRKLNDEKIDE 975
|
970
....*....|....*.
gi 446347494 860 YQEKYDGVKARIEQLK 875
Cdd:PTZ00419 976 LNEEIKQLEQAIEELK 991
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
17-876 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 854.24 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 17 YEEWVKNGYFKPSEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKL 96
Cdd:PLN02943 70 YNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVVEKML 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 97 NEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINW 176
Cdd:PLN02943 150 ASEGIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGSYMVNW 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 177 DPKARTALSDIEVIHEDVQGAFYHFKYPYADG-EGFIEIATTRPETMLGDTAIVVNPNDERYKDVIGKTVILPIV-GREL 254
Cdd:PLN02943 230 SPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGsEDFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMAIVPMTyGRHV 309
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 255 PILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYegmdRFDCRKQLVEDLKEQDLVIKI 334
Cdd:PLN02943 310 PIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLY----WFEAREKLWSDLEETGLAVKK 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 335 EDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKtDDRIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIP 414
Cdd:PLN02943 386 EPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVE-NGELTIIPERFEKIYNHWLSNIKDWCISRQLWWGHRIP 464
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 415 AWY--HKETGEIYV----GEEA--------PTDIENWqQDEDVLDTWFSSALWPFSTLGWPDLESEDFKRYYPTNVLVTG 480
Cdd:PLN02943 465 VWYivGKDCEEDYIvarsAEEAlekarekyGKDVEIY-QDPDVLDTWFSSALWPFSTLGWPDVSAEDFKKFYPTTVLETG 543
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 481 YDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSpGHDLRYS 560
Cdd:PLN02943 544 HDILFFWVARMVMMGIEFTGTVPFSYVYLHGLIRDSQGRKMSKTLGNVIDPLDTIKEFGTDALRFTLALGTA-GQDLNLS 622
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 561 TEKVESVWNFINKIWNGARFSLMNIGE-------------DFKVEDIDLSgnLSLADKWILTRLNETIATVTDLSDKYEF 627
Cdd:PLN02943 623 TERLTSNKAFTNKLWNAGKFVLQNLPSqsdtsawehilacKFDKEESLLS--LPLPECWVVSKLHELIDSVTTSYDKYFF 700
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 628 GEVGRALYNFIWDDFCDWYIEMSKIPMNGN-DEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPHQGETIVKAS 706
Cdd:PLN02943 701 GDVGREIYDFFWSDFADWYIEASKTRLYHSgDNSALSRAQAVLLYVFENILKLLHPFMPFVTEELWQALPYRKEALIVSP 780
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 707 WPEvRESLVFEESKQTMQQLVEIIKSVRQSRVEVNTPLSKEIPILIQAKDkEIETTLSQNKDYLIKFCNPSTLNISTDVE 786
Cdd:PLN02943 781 WPQ-TSLPKDLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVASA-EVIEYISKEKEVLALLSRLDLQNVHFTDS 858
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 787 IPEKAMTSVVIAG----KVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQDYQE 862
Cdd:PLN02943 859 PPGDANQSVHLVAseglEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAAEAEE 938
|
890
....*....|....
gi 446347494 863 KYDGVKARIEQLKA 876
Cdd:PLN02943 939 KIKLTKNRLAFLKS 952
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
15-560 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 732.68 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 15 GRYEEWVKNGYFKPS--EDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKV 92
Cdd:pfam00133 1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 93 EAKLN-EQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGE 171
Cdd:pfam00133 81 EKKLGiKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 172 RIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGEGF-IEIATTRPETMLGDTAIVVNPN----------------- 233
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGAsLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyilaeall 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 234 --------------DERYKDVIGKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDEN 299
Cdd:pfam00133 241 kslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVINPVDDD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 300 GKMNDKAGKYEGMDRFDCRKQLVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKtddR 379
Cdd:pfam00133 321 GTFTEEAPDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRATPQWFVRMDELADQALEAVE---K 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 380 IDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPAWYHKETGEIYVGEE---------APTDIENW------------- 437
Cdd:pfam00133 398 VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDTEEVVCRGElfelvagrfEEEGSIKWlhreakdklgygk 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 438 ---QQDEDVLDTWFSSALWPFSTLGWPDLESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVR 514
Cdd:pfam00133 478 gtlEQDEDVLDTWFSSGSWPFSTLGWPFVNTEEFKKFFPADMLLEGSDQTRGWFYRMIMLSTALTGSVPFKNVLVHGLVR 557
|
570 580 590 600
....*....|....*....|....*....|....*....|....*.
gi 446347494 515 AEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLAtGSSPGHDLRYS 560
Cdd:pfam00133 558 DEQGRKMSKSLGNVIDPLDVIDKYGADALRLWLA-NSDYGRDINLS 602
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
2-876 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 708.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 2 EMKPKYDPREVEAGRYEEWVKNGYFKPSEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGM 81
Cdd:PLN02381 95 QMAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGV 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 82 DHAGIATQAKVEAKL-NEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVD 160
Cdd:PLN02381 175 DHAGIATQVVVEKKLmRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVR 254
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQ----------------GAFYHFKYPYADGEGFIEIATTRPETMLG 224
Cdd:PLN02381 255 LYKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYPLEGGLGEIVVATTRIETMLG 334
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 225 DTAIVVNPNDERYKDVIGKTVILPIVGRELPILAD-EYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMN 303
Cdd:PLN02381 335 DTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTDDGKIN 414
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 304 DKAG-KYEGMDRFDCRKQLVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKTDD--RI 380
Cdd:PLN02381 415 SNGGsEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWFVNCSSMAKQALDAAIDGEnkKL 494
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 381 DFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPAWY-------HKETGE-----IYVGEEAPTDIENWQ---------- 438
Cdd:PLN02381 495 EFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtleddqLKELGSyndhwVVARNESDALLEASQkfpgkkfels 574
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 439 QDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDG 518
Cdd:PLN02381 575 QDPDVLDTWFSSGLFPLSVLGWPD-DTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQLGGDVPFRKVYLHPMIRDAHG 653
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 519 RKMSKSLGNGVDPMDVID-------------------------------------EYGADSLRYFLATGSSPGHDLRYST 561
Cdd:PLN02381 654 RKMSKSLGNVIDPLEVINgisleglhkrleegnldpkelvvakegqkkdfpngiaECGTDALRFALVSYTAQSDKINLDI 733
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 562 EKVESVWNFINKIWNGARFSLMNIGEDFKVEDIDLSGNLSLADKWILTRLNETIA-TVTDLsDKYEFGEVGRALYNFIWD 640
Cdd:PLN02381 734 LRVVGYRQWCNKLWNAVRFAMSKLGDDYTPPATLSVETMPFSCKWILSVLNKAISkTVSSL-DAYEFSDAASTVYSWWQY 812
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 641 DFCDWYIEMSKIPMNGNDEE---QKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPH-----QGETIVKASWPEVRE 712
Cdd:PLN02381 813 QFCDVFIEAIKPYFAGDNPEfasERAAAQDTLWICLDTGLRLLHPFMPFVTEELWQRLPQpkdhtRKDSIMISEYPSAVE 892
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 713 SLVFEESKQTMQQLVEIIKSVRQSRVEVNTPLSKE-IPILIQAKDKEIETTLSQNKDYLIKFCNPSTLNI--STDVEIPE 789
Cdd:PLN02381 893 AWTNEKVEYEMDLVLSTVKCLRSLRAEVLEKQKNErLPAFALCRNQEIAAIIKSHQLEILTLANLSSLKVllSENDAPPA 972
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 790 KAMTSVVIAG-KVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQDYQEKYDGVK 868
Cdd:PLN02381 973 GCAFENVNENlKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKMNASGYKEKVPANIQEEDARKLTKLLQELEFFE 1052
|
....*...
gi 446347494 869 ARIEQLKA 876
Cdd:PLN02381 1053 KESKRLEA 1060
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-748 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 668.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 1 MEMKPKYDPREVEAGRYEEWVKNGYFKPSEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPG 80
Cdd:PRK13208 4 PELPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQG 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 81 MDHAGIATQAKVEaklNEQGITRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVD 160
Cdd:PRK13208 84 WDDNGLPTERKVE---KYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 161 LYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQGAFYHFKYPYADGEGfIEIATTRPETMLGDTAIVVNPNDERYKDV 240
Cdd:PRK13208 161 LYKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDGEE-IEIATTRPELLPACVAVVVHPDDERYKHL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 241 IGKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDCRKQ 320
Cdd:PRK13208 240 VGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTIEEARKK 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 321 LVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLdnqKTDDRIDFYPQRFEHTFNQWMENIR- 399
Cdd:PRK13208 320 IVEDLKSGGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELL---ERGKEINWYPEHMRVRLENWIEGLNw 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 400 DWTISRQLWWGHQIPAWYHKETGEIYVGEEA-----PT------------DIENWQQDEDVLDTWFSSALWPFSTLGWPD 462
Cdd:PRK13208 397 DWCISRQRYFGTPIPVWYCKDCGHPILPDEEdlpvdPTkdeppgykcpqcGSPGFEGETDVMDTWATSSITPLIVTGWER 476
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 463 lESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADS 542
Cdd:PRK13208 477 -DEDLFEKVFPMDLRPQGHDIIRTWLFYTILRAYLLTGKLPWKNIMISGMVLDPDGKKMSKSKGNVVTPEELLEKYGADA 555
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 543 LRYFLAtGSSPGHDLRYSTEKVESVWNFINKIWNGARFSLMnIGEDFKVEDIDlsgNLSLADKWILTRLNETIATVTDLS 622
Cdd:PRK13208 556 VRYWAA-SARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLH-FSADPEPDKAE---VLEPLDRWILAKLAKVVEKATEAL 630
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 623 DKYEFGEVGRALYNFIWDDFCDWYIEMSK-IPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLphQGET 701
Cdd:PRK13208 631 ENYDFAKALEEIESFFWHVFCDDYLELVKsRAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSWL--YGGS 708
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|.
gi 446347494 702 IVKASWPEVRESLVFEESKQTMQQLVEIIKSVR----QSRVEVNTPLSKEI 748
Cdd:PRK13208 709 VHRASWPEPDEELIDEEDEELGELAKEILSAVRkyksEAGLSLNAPLKKVE 759
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
35-559 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 546.46 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 35 ETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGITRYDLGREKFLEQ 114
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIEGKTRHDLGREEFLEK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 115 AWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVihedv 194
Cdd:cd00817 81 CWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV----- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 195 qgafyhfkypyadgegfieiattrpetmlgdtaivvnpnderykdvigktvilpivgrelpiladeyvdidfgsgamkvt 274
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 275 pahdpndfeigqrhqleniivmdengkmndkagkyegmdrfdcrkqlvedlkeqdlvikiedhvhsvghSERSGAVVEPY 354
Cdd:cd00817 156 ---------------------------------------------------------------------CSRSGDVIEPL 166
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 355 LSTQWFVRMEDLAKRSLDNQKtDDRIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPAWYHKETGEIYVGEEAPTDI 434
Cdd:cd00817 167 LKPQWFVKVKDLAKKALEAVK-EGDIKFVPERMEKRYENWLENIRDWCISRQLWWGHRIPAWYCKDGGHWVVAREEDEAI 245
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 435 -------------ENWQQDEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDR 501
Cdd:cd00817 246 dkaapeacvpcggEELKQDEDVLDTWFSSSLWPFSTLGWPE-ETKDLKKFYPTSLLVTGHDIIFFWVARMIMRGLKLTGK 324
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*...
gi 446347494 502 RPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRY 559
Cdd:cd00817 325 LPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGYGADALRFTLASAATQGRDINL 382
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
6-802 |
9.49e-132 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 417.56 E-value: 9.49e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 6 KYDPREVEAGRYEEWVKNGYFKPSEDKSK--ETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMD- 82
Cdd:COG0060 15 RANLPKREPEILKFWEENDIYEKSREARAgrPKFVLHDGPPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDc 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 83 HaGIATQAKVEAKLneqGITRYD---LGREKF--------LEQAWDWKEEyasFIRaqwakLGLGLDYSRERFTLD---- 147
Cdd:COG0060 95 H-GLPIELKVEKEL---GIKKKDiekVGIAEFrekcreyaLKYVDEQRED---FKR-----LGVWGDWDNPYLTMDpeye 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 148 EGLSKAVKKvfvdLYNKGIIYRGERIINWDPKARTALSDIEVIHEDVQ--GAFYHFK-----YPYADGEGFIEIATTRPE 220
Cdd:COG0060 163 ESIWWALKK----LYEKGLLYKGLKPVPWCPRCGTALAEAEVEYKDVTspSIYVKFPvkdekALLLLEDAYLVIWTTTPW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 221 TMLGDTAIVVNP----------NDERY-------KDVIGK------TVILPIVGREL-------------------PILA 258
Cdd:COG0060 239 TLPANLAVAVHPdidyvlvevtGGERLilaealvEAVLKElgiedyEVLATFKGAELeglryehpfyyvvgydrahPVIL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 259 DEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRFDCRKQLVEDLKEQDLVIKIEDHV 338
Cdd:COG0060 319 GDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRFTEEAPLFAGLFVKDANPAIIEDLKERGALLAREKIT 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 339 HSVGHSERSGAvveP--YLST-QWFVRMEDLAKRSLDNqktDDRIDFYPQ----RFEHtfnqWMENIRDWTISRQLWWGH 411
Cdd:COG0060 399 HSYPHCWRCKT---PliYRATpQWFISMDKLRDRALEA---IEKVNWIPEwgegRFGN----MLENRPDWCISRQRYWGV 468
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 412 QIPAWYHKETGEIYV---------------GEEAPTDIE-----------------NWQQDEDVLDTWFSSALWPFSTLG 459
Cdd:COG0060 469 PIPIWVCEDCGELHRteevigsvaelleeeGADAWFELDlhrpfldetlkcpkcggTMRRVPDVLDVWFDSGSMHFAVLE 548
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 460 wpdlESEDFKryYPTNVLVTGYDII---FF---WVARMIFqgleftDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMD 533
Cdd:COG0060 549 ----NREELH--FPADFYLEGSDQTrgwFYsslLTSTALF------GRAPYKNVLTHGFVLDEDGRKMSKSLGNVVDPQE 616
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 534 VIDEYGADSLRYFLATgSSPGHDLRYSTEKVESVWNFINKIWNGARFSLMNI-GEDFKVEDIDLSGNLSLaDKWILTRLN 612
Cdd:COG0060 617 VIDKYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRLRNTYRFLLANLdDFDPAEDAVPYEDLPEL-DRWILSRLN 694
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 613 ETIATVTDLSDKYEFGEVGRALYNFIWDDFCDWYIEMSK----IpmNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVT 688
Cdd:COG0060 695 ELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDISKdrlyT--EAADSLDRRAAQTTLYEVLETLVRLLAPILPFTA 772
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 689 EKIWQSLPHQ-GETIVKASWPEVRESLVFEESKQTMQQLVEIIKSVRQS----RVE--VNTPLSKEIpilIQAKDKEIET 761
Cdd:COG0060 773 EEIWQNLPGEaEESVHLADWPEVDEELIDEELEAKWDLVREVRSAVLKAleaaRKEklIRQPLEAAV---VLYADEELAA 849
|
890 900 910 920
....*....|....*....|....*....|....*....|..
gi 446347494 762 TLSQNKDYLIKFCNPSTLNISTDVE-IPEKAMTSVVIAGKVV 802
Cdd:COG0060 850 ALESLGDLLAEELNVSEVELVDDAEdLGKDALKALDVEGISV 891
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
10-744 |
2.99e-75 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 265.10 E-value: 2.99e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 10 REVEAGRYeeWVKNGYFKP-SEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIAT 88
Cdd:PLN02843 8 REPEIQKL--WEENQVYKRvSDRNNGESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPI 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 89 QAKVEAKLNEQgiTRYDLGREKFLEQAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIY 168
Cdd:PLN02843 86 ELKVLQSLDQE--ARKELTPIKLRAKAAKFAKKTVDTQRESFKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNGYIY 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 169 RGERIINWDPKARTALSDIEV------IHEDVQGAFYHFKYPYADGE--------GFIEIATTRPETMLGDTAIVVNP-- 232
Cdd:PLN02843 164 RGRKPVHWSPSSRTALAEAELeypeghVSKSIYVAFPVVSPSETSPEeleeflpgLSLAIWTTTPWTMPANAAVAVNDkl 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 233 -----------NDERYKD-------------------------------------VIGKTV----------ILPIVGREL 254
Cdd:PLN02843 244 qysvvevqsfsEDESTSGgnkkkrpgnvlkeqqklflivatdlvpaleakwgvklVVLKTFpgsdlegcryIHPLYNRES 323
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 255 PILAD-EYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENIIVMDENGKMNDKAGKYEGMDRF-DCRKQLVEDLKEQDLVI 332
Cdd:PLN02843 324 PVVIGgDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLSVLgEGNAAVVEALDEAGSLL 403
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 333 KIEDHVHSVGHSERSGavvEPYL---STQWFVRMEDLAKRSLDnqkTDDRIDFYPQRFEHTFNQWMENIRDWTISRQLWW 409
Cdd:PLN02843 404 MEEAYGHKYPYDWRTK---KPTIfraTEQWFASVEGFRQAALD---AIDKVKWIPAQGENRIRAMVSGRSDWCISRQRTW 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 410 GHQIPAWYHKETGEIYVGEEAPTDIE-----------------------------NWQQDEDVLDTWFSSAlwpfSTlgW 460
Cdd:PLN02843 478 GVPIPVFYHVETKEPLMNEETIAHVKsivaqkgsdawwymdvedllpekyrdkasDYEKGTDTMDVWFDSG----SS--W 551
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 461 PDLESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVID---- 536
Cdd:PLN02843 552 AGVLGSREGLSYPADLYLEGSDQHRGWFQSSLLTSVATKGKAPYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEggkn 631
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 537 -----EYGADSLRYFLATGSSPGhDLRYSTEKVESVWNFINKIWNGARFSLMNIGeDFKVEDIDLSGNLSLADKWILTRL 611
Cdd:PLN02843 632 qkqepAYGADVLRLWVASVDYTG-DVLIGPQILKQMSDIYRKLRGTLRYLLGNLH-DWKPDNAVPYEDLPSIDKYALFQL 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 612 NETIATVTDLSDKYEFGEVGRALYNFIWDDFCDWYIEMSK--IPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTE 689
Cdd:PLN02843 710 ENVVNEIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKdrLYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAE 789
|
810 820 830 840 850 860
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446347494 690 KIWQSLPHQ-----GETIVKASWPEVRESL--VFEESKQTMQQLVEIiksvrqsRVEVNTPL 744
Cdd:PLN02843 790 DAWQNLPFQedgsaAESVFEAGWPTPNEEWlsFPAEDVDFWSLLLEV-------RDEVNKVL 844
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
36-558 |
1.11e-72 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 241.17 E-value: 1.11e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 36 TYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGITRYdlgREKFLEQA 115
Cdd:cd00668 1 KFYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERKGGRKKKTIW---IEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 116 WDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERiinwdpkartalsdievihedvq 195
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTH----------------------- 134
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 196 gafyhfkypyadgegfieiattrpetmlgdtaivvnpnderykdvigktvilpivgrelpiladeyvdidfgsgamkvtp 275
Cdd:cd00668 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 276 ahdpndfeigqrhqleniivmdengkmndkagkyegmdrfdcrkqlvedlkeqdLVIKIEdhvhsvghsersgavvepyl 355
Cdd:cd00668 135 ------------------------------------------------------PVRITE-------------------- 140
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 356 stQWFVRMEDLAKRSLDNQKtddRIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPawyhketgeiyvgeeaptdie 435
Cdd:cd00668 141 --QWFFDMPKFKEKLLKALR---RGKIVPEHVKNRMEAWLESLLDWAISRQRYWGTPLP--------------------- 194
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 436 nwqqdEDVLDTWFSSALWPFSTLGWPDlESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRA 515
Cdd:cd00668 195 -----EDVFDVWFDSGIGPLGSLGYPE-EKEWFKDSYPADWHLIGKDILRGWANFWITMLVALFGEIPPKNLLVHGFVLD 268
|
490 500 510 520
....*....|....*....|....*....|....*....|...
gi 446347494 516 EDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLR 558
Cdd:cd00668 269 EGGQKMSKSKGNVIDPSDVVEKYGADALRYYLTSLAPYGDDIR 311
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
20-744 |
1.52e-68 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 247.72 E-value: 1.52e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 20 WVKNGYFKP--SEDKSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLn 97
Cdd:PLN02882 21 WSEIDAFKTqlKRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWDCHGLPVEYEIDKKL- 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 98 eqGITRydlgREKFLEQAWD-WKEEYASFIR---AQWAK----LGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYR 169
Cdd:PLN02882 100 --GIKR----RDDVLKMGIDkYNEECRSIVTrysKEWEKtvtrTGRWIDFENDYKTMDPKFMESVWWVFKQLFEKGLVYK 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 170 GERIINWDPKARTALSDIEV--IHEDVQGAFYHFKYPY---ADGEGFIEIATTrPETMLGDTAIVVNPNDE----RYKDV 240
Cdd:PLN02882 174 GFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIvgdPDNASFVAWTTT-PWTLPSNLALCVNPNFTyvkvRNKYT 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 241 iGKTVI--------LP------------------------IVGREL------PI--------------LADEYVDIDFGS 268
Cdd:PLN02882 253 -GKVYIvaesrlsaLPtakpkskkgskpenaaegyevlakVPGSSLvgkkyePLfdyfsefsdtafrvVADDYVTDDSGT 331
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 269 GAMKVTPAHDPNDFEIGQRHQL----ENIIV-MDENGKMNDKAGKYEGMDRFDCRKQLVEDLKEQDLVIKIEDHVHSVGH 343
Cdd:PLN02882 332 GVVHCAPAFGEDDYRVCLANGIiekgGNLPVpVDDDGCFTEKVTDFSGRYVKDADKDIIAAIKAKGRLVKSGSITHSYPF 411
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 344 SERSG------AVvepylsTQWFVRMEDLAKRSLDNQKTDDRIDFYPQrfEHTFNQWMENIRDWTISRQLWWGHQIPAWY 417
Cdd:PLN02882 412 CWRSDtpliyrAV------PSWFVKVEEIKDRLLENNKQTYWVPDYVK--EKRFHNWLENARDWAVSRSRFWGTPLPIWI 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 418 HKETGEIYV-----------GEEApTDIENWQQD------------------EDVLDTWFSSALWPFSTLGWPDLESEDF 468
Cdd:PLN02882 484 SDDGEEVVVigsiaeleklsGVKV-TDLHRHFIDhitipssrgpefgvlrrvDDVFDCWFESGSMPYAYIHYPFENKELF 562
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 469 KRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLA 548
Cdd:PLN02882 563 EKNFPADFVAEGLDQTRGWFYTLMVLSTALFDKPAFKNLICNGLVLAEDGKKMSKSLKNYPDPNEVIDKYGADALRLYLI 642
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 549 tgSSP---GHDLRYSTEKVESVWNFINKIW-NGARFSLMNI-------GEDFKVEDID-LSGNLSLADKWILTRLNETIA 616
Cdd:PLN02882 643 --NSPvvrAEPLRFKEEGVFGVVKDVFLPWyNAYRFLVQNAkrlevegGAPFVPLDLAkLQNSANVLDRWINSATQSLVK 720
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 617 TVTDLSDKYEFGEVGRALYNFIwDDFCDWYIEMSKIPMNGND-EEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSL 695
Cdd:PLN02882 721 FVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLKGRTgEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVLYQNL 799
|
810 820 830 840 850
....*....|....*....|....*....|....*....|....*....|...
gi 446347494 696 ----PHQGETIVKASWPEVRESLVFEESKQTMQQLVEIIKSVRQSRVEVNTPL 744
Cdd:PLN02882 800 rkvlPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPL 852
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
50-872 |
1.66e-64 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 233.22 E-value: 1.66e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 50 LHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAG--IATQAKVEAKLNEQGITRY-DLGR--EKFLEQAWD---WKEE 121
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLFPMAFHVTGtpILGIAERIARGDPETIELYkSLYGipEEELEKFKDpeyIVEY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 122 YASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIH-EDVQGAFYH 200
Cdd:PRK12300 81 FSEEAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDHDLLDgEEPEIVEYT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 201 FKYPYADGEGFIEIATTRPETMLGDTAIVVNPN---------DERY-------------------------KDVIGKTVI 246
Cdd:PRK12300 161 LIKFEESEDLILPAATLRPETIFGVTNLWVNPDatyvkaevdGEKWivskeaaeklsfqdrdveiieeikgSELIGKKVK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 247 LPIVGRELPILADEYVDIDFGSG-AMKVtPAHDPNDF----EIGQRHQLENII--------------------------- 294
Cdd:PRK12300 241 NPVTGKEVPILPADFVDPDNGTGvVMSV-PAHAPYDYvalrDLKKNKELLDVIepiplievegygefpakevveklgiks 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 295 ----VMDE-----------NGKMNDKAGKYEGMDRFDCRKQLVEDLKEQDLVIKI----EDHVHSvghseRSGA-VVEPY 354
Cdd:PRK12300 320 qedpELEEatkevyraefhKGVLKENTGEYAGKPVREAREKITKDLIEKGIADIMyefsNRPVYC-----RCGTeCVVKV 394
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 355 LSTQWFVRMED-----LAKRSLDNqktddrIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPaWYHKETGE------ 423
Cdd:PRK12300 395 VKDQWFIDYSDpewkeLAHKALDN------MEIIPEEYRKEFENTIDWLKDRACARRRGLGTRLP-WDEEWIIEslsdst 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 424 IYVG--------EEAPTDIEnwQQDEDVLDTWFssalwpfstLGWPDLES----------------EDFKRYYPTNVLVT 479
Cdd:PRK12300 468 IYMAyytiahkiREYGIKPE--QLTPEFFDYVF---------LGKGDPEEvskktgipkeileemrEEFLYWYPVDWRHS 536
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 480 GYDII-----FFW---VArmIFqGLEFTDRRpfndVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGS 551
Cdd:PRK12300 537 GKDLIpnhltFFIfnhVA--IF-PEEKWPRG----IVVNGFVLLE-GKKMSKSKGNVIPLRKAIEEYGADVVRLYLTSSA 608
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 552 SPGHDLRYSTEKVESVWNFINKIWNGARfslmnigedfKVEDIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGE-V 630
Cdd:PRK12300 609 ELLQDADWREKEVESVRRQLERFYELAK----------ELIEIGGEEELRFIDKWLLSRLNRIIKETTEAMESFQTRDaV 678
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 631 GRALYNFIwDDFcDWYIEMSKIPmngndeeqkqvTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPHQGeTIVKASWPEV 710
Cdd:PRK12300 679 QEAFYELL-NDL-RWYLRRVGEA-----------NNKVLREVLEIWIRLLAPFTPHLAEELWHKLGGEG-FVSLEKWPEP 744
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 711 RESLVFEESKQTMQQLVEIIKSVRqsrvevntplskEIPILIQAKDKEIETTLSQNKDYLIkfcnpstLNISTDVEIPEK 790
Cdd:PRK12300 745 DESKIDEEAELAEEYVKRLIEDIR------------EILKVAKIKPKKVYIYVAPDWKYEV-------LEIAAENGDVKE 805
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 791 AMtsvviagKVVLPLEGLIDMDKEISRLEKELAKLQSELDRVDKKLSNENfvskapekvINEEK--RKKQDYQEKYDGVK 868
Cdd:PRK12300 806 AI-------KELMKDEELRKHGKEVAKLAQKIVKEVLKLDKEVRKLILKN---------IDEEEvlEEAKDFLEKELGVE 869
|
....
gi 446347494 869 ARIE 872
Cdd:PRK12300 870 VEIY 873
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
559-695 |
2.66e-64 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 211.65 E-value: 2.66e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 559 YSTEKVESVWNFINKIWNGARFSLMNIGEDFkvEDIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFI 638
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDD--EPEEDPESLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFF 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446347494 639 WDDFCDWYIEMSKIPMNGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSL 695
Cdd:cd07962 79 WNDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQRL 135
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
3-747 |
7.73e-56 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 207.21 E-value: 7.73e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 3 MKPKYDPREVEAGRYEEWVKNGYFKPSEDKSKETYTIVI--PPPnvTGKLHLGHAWDTTLQDIITRMKRMQGYDTLY--- 77
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYYVLDmfPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLHpmg 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 78 -----LPgmdhagiATQAKVE-----AKLNEQGITRYdlgrekfleqawdwkeeyasfiRAQWAKLGLGLDYSRERFTLD 147
Cdd:COG0495 79 wdafgLP-------AENAAIKngvhpAEWTYENIANM----------------------RRQLKRLGLSYDWSREIATCD 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 148 EGLSKAVKKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIH------------------------------------ 191
Cdd:COG0495 130 PEYYKWTQWIFLQLYEKGLAYRKEAPVNWCPVDQTVLANEQVIDgrcwrcgapvekkelpqwflkitdyadellddldkl 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 192 ----EDV-----------QGAfyHFKYPYADGEGFIEIATTRPETMLGDTAIVVNP-------------NDE-------- 235
Cdd:COG0495 210 dgwpEKVktmqrnwigrsEGA--EVDFPVEGSDEKITVFTTRPDTLFGATFMVLAPehplvkelatpeqNAAvaafieea 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 236 RYKDVI--------------GKTVILPIVGRELPILADEYVDIDFGSGA-MKVtPAHDPNDFEIGQRHQLENIIVMD--- 297
Cdd:COG0495 288 KKKSEIertsetkektgvftGLYAINPLTGEKIPIWIADYVLMDYGTGAvMAV-PAHDQRDFEFAKKYGLPIKQVIAped 366
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 298 ------------ENGKM-NdkAGKYEGMDRFDCRKQLVEDLKEQdlvikiedhvhsvGHSERSgavvepylsTQWfvRMe 364
Cdd:COG0495 367 gddpdileeaytGDGVLiN--SGEFDGLDSEEAKEAIIEWLEEK-------------GLGKRK---------VNY--RL- 419
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 365 dlakrsldnqktddridfypqrfehtfnqwmeniRDWTISRQLWWGHQIPAWYHKETGEIYVGEEA-----PTD------ 433
Cdd:COG0495 420 ----------------------------------RDWLISRQRYWGEPIPIIHCEDCGVVPVPEDQlpvelPEDvdfdpt 465
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 434 -------IENWQQDE------------DVLDTWF-SSalWPFstLGWPD-------LESEDFKRYYP------------- 473
Cdd:COG0495 466 ggsplarAPEWVNVTcpkcggparretDTMDTFVdSS--WYY--LRYTDphndeapFDPEAANYWLPvdqyiggiehail 541
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 474 --------TNVLvtgYDIiffwvarmifqGLEFTDRrPFNDVLLHGLVR--AEDGR------KMSKSLGNGVDPMDVIDE 537
Cdd:COG0495 542 hllyarffTKVL---RDL-----------GLVSFDE-PFKRLLTQGMVLevGKDGVviggieKMSKSKGNVVDPDEIIEK 606
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 538 YGADSLRYFLATGSSPGHDLRYSTEKVESVWNFINKIWngarfslmNIGEDFKVEDIDLSGNLSLADKWILTRLNETIAT 617
Cdd:COG0495 607 YGADTLRLFEMFAGPPERDLEWSDSGVEGAYRFLNRVW--------RLVVDEAEALKLDVADLSEADKELRRALHKTIKK 678
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 618 VTDLSDKYEFGEVGRALYNFIwddfcdwyIEMSKIpmngndEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPH 697
Cdd:COG0495 679 VTEDIERLRFNTAIAALMELV--------NALYKA------KDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLGH 744
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|....*
gi 446347494 698 QGeTIVKASWPEVRESLVFEESkqtmqqlVEII-----KsVRqSRVEVNTPLSKE 747
Cdd:COG0495 745 EG-SVADAPWPEADEAALVEDE-------VTIVvqvngK-VR-GKIEVPADASKE 789
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
35-559 |
9.08e-56 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 195.91 E-value: 9.08e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 35 ETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAKLNEQGIT-RYDLGREKFLE 113
Cdd:cd00818 1 PEFVFHDGPPYANGLPHYGHALNKILKDIINRYKTMQGYYVPRRPGWDCHGLPIELKVEKELGISGKKdIEKMGIAEFNA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 114 QAWDWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWdpkartalsdievihed 193
Cdd:cd00818 81 KCREFALRYVDEQEEQFQRLGVWVDWENPYKTMDPEYMESVWWVFKQLHEKGLLYRGYKVVPW----------------- 143
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 194 vqgafyhfkypyadgegfieiattrpetmlgdtaivvnpnderykdvigktvilPIVGRELPiladeyvdidfgsgamkv 273
Cdd:cd00818 144 ------------------------------------------------------PLIYRATP------------------ 151
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 274 tpahdpndfeigqrhqleniivmdengkmndkagkyegmdrfdcrkqlvedlkeqdlvikiedhvhsvghsersgavvep 353
Cdd:cd00818 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 354 ylstQWFVRMEDLAKRSLDNqktDDRIDFYPQRFEHTFNQWMENIRDWTISRQLWWGHQIPAWYHKETGEIYVGEEaptd 433
Cdd:cd00818 152 ----QWFIRVTKIKDRLLEA---NDKVNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCGEVLVRRV---- 220
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 434 ienwqqdEDVLDTWFSSALWPFSTLGWPdLESEDFKRYYPTNVLVTGYDIIFFWvarmiFQGLEFT-----DRRPFNDVL 508
Cdd:cd00818 221 -------PDVLDVWFDSGSMPYAQLHYP-FENEDFEELFPADFILEGSDQTRGW-----FYSLLLLstalfGKAPYKNVI 287
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 446347494 509 LHGLVRAEDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRY 559
Cdd:cd00818 288 VHGFVLDEDGRKMSKSLGNYVDPQEVVDKYGADALRLWVASSDVYAEDLRF 338
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
32-695 |
5.02e-48 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 185.56 E-value: 5.02e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 32 KSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEaklNEQGITRydlgREKF 111
Cdd:PTZ00427 99 KNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDCHGLPIEYEIE---KENNINK----KEDI 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 112 LEQAWDWKEEYASFI----RAQWAK----LGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWDPKARTA 183
Cdd:PTZ00427 172 LKMGIDVYNEKCRGIvlkySNEWVKtverIGRWIDFKNDYKTMDKTFMESVWWVFSELYKNNYVYKSFKVMPYSCKCNTP 251
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 184 LSDIEV------------------------------IHEDVQGAFYHFKYPYAD-------------------GEGFIEI 214
Cdd:PTZ00427 252 ISNFELnlnykdtpdpsiiisfvlcsdfpkveeecnIEEDKQLLGEKYSVLYNNkrensnngnnnstnnvcyaQHSEILA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 215 ATTRPETMLGDTAIVVNPN--------------------------DERYKDVIGKTVILPIVGRELP------------- 255
Cdd:PTZ00427 332 WTTTPWTLPSNLALCVNEHftylrihhvksnrvvivgecrlewimKELKWNVEDLKIVNRFKGKELKglrykplftnfye 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 256 ----------ILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQL----ENIIV--MDENGKMNDKAGKYEGMDRFDCRK 319
Cdd:PTZ00427 412 kynfkeraykILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKNGVidpeKNIFIdpLDANGYFTNEVEEVQNLYIKEADN 491
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 320 QLVEDLKEQDLVIKIEDHVHSVGHSERSGAVVEPYLSTQWFVRMEDLAKRSLDNQKTDDRIDFYPQrfEHTFNQWMENIR 399
Cdd:PTZ00427 492 VIKKKLKNENRLLSNNTIVHSYPFCWRSDTPLIYRAIPAWFIRVSNSTNELVKNNETTYWIPAHIK--EKKFHNWIKDAK 569
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 400 DWTISRQLWWGHQIPAWYHKETGEIYVGEEAP---------------------TDIENWQQDE--------DVLDTWFSS 450
Cdd:PTZ00427 570 DWCISRNRYWGTPIPIWADEKMETVICVESIKhleelsgvknindlhrhfidhIEIKNPKGKTypklkripEVFDCWFES 649
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 451 ALWPFSTLGWP-DLESEDFKRYYPTNVLVTGYDIIFFWVARMIFQGLEFTDRRPFNDVLLHGLVRAEDGRKMSKSLGNGV 529
Cdd:PTZ00427 650 GSMPYAKVHYPfSTEKEDFHKIFPADFIAEGLDQTRGWFYTLLVISTLLFDKAPFKNLICNGLVLASDGKKMSKRLKNYP 729
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 530 DPMDVIDEYGADSLR-YFLATGSSPGHDLRYSTEKV-ESVWNFINKIWNGARFSLMNI-------GEDFKVEDIDLSGNL 600
Cdd:PTZ00427 730 DPLYILDKYGADSLRlYLINSVAVRAENLKFQEKGVnEVVKSFILPFYHSFRFFSQEVtryeclnKKQFLFNTDYIYKND 809
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 601 SLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwDDFCDWYIEMSKIPMNGN-DEEQKQVTRSVLSYTLDNIMRM 679
Cdd:PTZ00427 810 NIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFI-ENLTNWYIRLNRDRMRGSlGEENCLQSLCTTYRTLHLFTVL 888
|
810
....*....|....*.
gi 446347494 680 LHPFMPFVTEKIWQSL 695
Cdd:PTZ00427 889 MAPFTPFITEYIYQQL 904
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
604-752 |
5.57e-43 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 152.56 E-value: 5.57e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 604 DKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIWDDFCDWYIEMSKIPMNGNDEEQKqvTRSVLSYTLDNIMRMLHPF 683
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLYGEEPDSR--AQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446347494 684 MPFVTEKIWQSlphqgETIVKASWPEVRESLVFEESKQtMQQLVEIIKSVRQSRVEVNTPLSKEIPILI 752
Cdd:pfam08264 79 MPFITEELWQK-----ESIHLAPWPEDAELEEAELEEA-FELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
41-714 |
9.44e-40 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 155.27 E-value: 9.44e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 41 IPPPNvtGKLHLGHAWdTTLQ-DIITRMKRMQGYDTLYLPGMD-HagiatQAKVEAKLNEQGITrydlgrekflEQAW-D 117
Cdd:COG0143 9 IPYAN--GPPHIGHLY-TYIPaDILARYQRLRGHDVLFVTGTDeH-----GTKIELAAEKEGIT----------PQELvD 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 118 wkeEYASFIRAQWAKLGLGLD-YSRerfTLDEGLSKAVKKVFVDLYNKGIIYRGEriinwdpkartalsdIEVIHEDVQG 196
Cdd:COG0143 71 ---RIHAEFKELFEKLGISFDnFIR---TTSPEHKELVQEIFQRLYDNGDIYKGE---------------YEGWYCPECE 129
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 197 AFYHfkypyadgegfieiattrpetmlgdtaivvnpndERYkdVIGKTvilPIVGRElpilaDEYVDidfgsgamkvtpa 276
Cdd:COG0143 130 RFLP----------------------------------DRY--VEGTC---PKCGAE-----DAYGD------------- 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 277 hdpndfeigqrhQLENiivmdengkmndkagkyegmdrfdCRKQLV-EDLKEQDLVIkiedhvhsvghserSGAVVEPYL 355
Cdd:COG0143 153 ------------QCEN------------------------CGATLEpTELINPRSAI--------------SGAPPELRE 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 356 STQWFVRMEDLAKRSLDNqkTDDRIDFYPQRFehtfNQ---WMEN-IRDWTISRQLWWGHQIPaWYHKETgeIYVgeeap 431
Cdd:COG0143 183 EEHYFFRLSKYQDRLLEW--IEENPDIQPEVR----NEvlsWLKEgLQDLSISRDFDWGIPVP-GDPGKV--FYV----- 248
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 432 tdienwqqdedvldtWFsSALWPF--STLGWPD--LESEDFKRYYP----TNVLVTGYDIIFF----WVArMifqgLEFT 499
Cdd:COG0143 249 ---------------WF-DALIGYisATKGYADdrGLPEDFEKYWPapdtELVHFIGKDIIRFhaiiWPA-M----LMAA 307
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 500 DRRPFNDVLLHG--LVraeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWN-------- 569
Cdd:COG0143 308 GLPLPKKVFAHGflTV---EGEKMSKSRGNVIDPDDLLDRYGPDALRYYLLREVPFGQDGDFSWEDFVARVNsdlandlg 384
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 570 --------FINKIWNGarfslmnigedfKVEDIdlsGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwdD 641
Cdd:COG0143 385 nlasrtlsMIHKYFDG------------KVPEP---GELTEADEELLAEAEAALEEVAEAMEAFEFRKALEEIMALA--R 447
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347494 642 FCDWYIEMSKiPMNGNDEEQKQVTRSVLSYTLD---NIMRMLHPFMPFVTEKIWQSLphqGETIVKASWPEVRESL 714
Cdd:COG0143 448 AANKYIDETA-PWKLAKDEDPERLATVLYTLLEalrILAILLKPFLPETAEKILEQL---GLEGDELTWEDAGWPL 519
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
11-723 |
1.38e-38 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 155.37 E-value: 1.38e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 11 EVEAGRYEEWVKNGYFK-PSE-DKSKETYTIV--IPPPNVTGkLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGI 86
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRtPDDvDTSKPKFYVLdmFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 87 -ATQAKVEAKLNEQGITRYDLGRekfleqawdwkeeyasfIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKG 165
Cdd:PLN02563 163 pAEQYAIETGTHPKITTLKNIAR-----------------FRSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKRG 225
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 166 IIYRGERIINWDPKARTALSDIEVIH------------------------------EDV--------------------Q 195
Cdd:PLN02563 226 LAYQAEVPVNWCPALGTVLANEEVVDglsergghpvirkpmrqwmlkitayadrllEDLddldwpesikemqrnwigrsE 305
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 196 GAFYHFKYPYADG---EGFIEIATTRPETMLGDTAIVVNP---------------NDERYKDV----------------- 240
Cdd:PLN02563 306 GAELDFSVLDGEGkerDEKITVYTTRPDTLFGATYLVVAPehpllsslttaeqkeAVEEYVDAasrksdlertelqkekt 385
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 241 ---IGKTVILPIVGRELPILADEYVDIDFGSGAMKVTPAHDPNDFEIGQRHQLENI-IVMDENGKMNDKAGKYEG---MD 313
Cdd:PLN02563 386 gvfTGSYAINPATGEAIPIWVADYVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKwVVKPADGNEDDAEKAYTGegvIV 465
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 314 RFDCRKQLVEDLKEQDLVIKIEDHVHSVGHSERsgavvepylstqwfvrmedlakrsldnqktddRIDFypqrfehtfnq 393
Cdd:PLN02563 466 NSSSSGLDINGLSSKEAAKKVIEWLEETGNGKK--------------------------------KVNY----------- 502
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 394 wmeNIRDWTISRQLWWGHQIPAWYHKETGEIYVGEEA-------------PTD--------IENWQQDEDVLD-TWFSSA 451
Cdd:PLN02563 503 ---KLRDWLFARQRYWGEPIPVVFLEDSGEPVPVPESdlpltlpelddftPTGtgepplakAVSWVNTVDPSSgKPARRE 579
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 452 L-----WPFST---LGWPD------LESEDFKRYY-PTNVLVTGYD-----IIF--FW---------------VARMIFQ 494
Cdd:PLN02563 580 TntmpqWAGSCwyyLRFMDpknsnaLVDKEKEKYWmPVDLYVGGAEhavlhLLYarFWhkvlydigvvstkepFQCLVNQ 659
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 495 GL-----EFTDRR-----------------------PFNDVLLHG--LVRAEDGR--------KMSKSLGNGVDPMDVID 536
Cdd:PLN02563 660 GMilgevEYTAFKdsdgeyvsadtadrlgelqqekiPEEKVIKSGdsFVLKDDPSirliarahKMSKSRGNVVNPDDVVS 739
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 537 EYGADSLR-YFLATGssPGHDLR-YSTEKVESVWNFINKIWNGARFSLMNIGEdFKVEDIDLSGNLSLADkwiLTRLNET 614
Cdd:PLN02563 740 EYGADSLRlYEMFMG--PLRDSKtWSTSGVEGVHRFLGRTWRLVVGAPLPDGS-FRDGTVVTDEEPSLEQ---LRLLHKC 813
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 615 IATVTDLSDKYEFGEVGRALYNFI-----WDDfcdwyiemskipmngndeeqkqVTRSVL-SYTLdnimrMLHPFMPFVT 688
Cdd:PLN02563 814 IAKVTEEIESTRFNTAISAMMEFTnaaykWDK----------------------VPREAIePFVL-----LLSPYAPHLA 866
|
890 900 910
....*....|....*....|....*....|....*
gi 446347494 689 EKIWQSLPHQGeTIVKASWPEVRESLVfEESKQTM 723
Cdd:PLN02563 867 EELWFRLGHSN-SLAYEPWPEANPSYL-VDDTVVL 899
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
35-700 |
1.11e-36 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 145.41 E-value: 1.11e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 35 ETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMD-HagiatQAKVEAKLNEQGITRYDLGREkfle 113
Cdd:PRK11893 1 KKFYITTPIYYPNGKPHIGHAYTTLAADVLARFKRLRGYDVFFLTGTDeH-----GQKIQRKAEEAGISPQELADR---- 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 114 qawdwkeeYASFIRAQWAKLglglDYSRERF--TLDEGLSKAVKKVFVDLYNKGIIYRGEriinwdpkartalsdievih 191
Cdd:PRK11893 72 --------NSAAFKRLWEAL----NISYDDFirTTDPRHKEAVQEIFQRLLANGDIYLGK-------------------- 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 192 edVQGafyhfkyPYAdgegfieiattrpetmlgdtaivvnPNDERYK---DVIGKTVILPIVGRELpiladEYVDidfgs 268
Cdd:PRK11893 120 --YEG-------WYC-------------------------VRCEEFYtesELIEDGYRCPPTGAPV-----EWVE----- 155
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 269 gamkvtpahdpndfEigqrhqlENIIVmdengkmndKAGKYegmdrfdcrkqlvedlkeQDlviKIEDHvhsvghsersg 348
Cdd:PRK11893 156 --------------E-------ESYFF---------RLSKY------------------QD---KLLEL----------- 173
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 349 avvepYLSTQWFVRMEDlakrsldnqktddridfypqRFEHTFNQWMENIRDWTISRQ-LWWGhqIPawyhketgeiyvg 427
Cdd:PRK11893 174 -----YEANPDFIQPAS--------------------RRNEVISFVKSGLKDLSISRTnFDWG--IP------------- 213
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 428 eeaptdienWQQDED-VLDTWFSsALWPF-STLGWPD---LESEDFKRYYPTNVLVTGYDIIFF----WVARMIFQGLEF 498
Cdd:PRK11893 214 ---------VPGDPKhVIYVWFD-ALTNYlTALGYPDdeeLLAELFNKYWPADVHLIGKDILRFhavyWPAFLMAAGLPL 283
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 499 TDRrpfndVLLHG-LVRaeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKVESVWN--FINKIW 575
Cdd:PRK11893 284 PKR-----VFAHGfLTL--DGEKMSKSLGNVIDPFDLVDEYGVDAVRYFLLREIPFGQDGDFSREAFINRINadLANDLG 356
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 576 NGARFSLMNIGEDFKVEdIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwdDFCDWYIEMSKiPMN 655
Cdd:PRK11893 357 NLAQRTLSMIAKNFDGK-VPEPGALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQA-PWS 432
|
650 660 670 680
....*....|....*....|....*....|....*....|....*....
gi 446347494 656 GNDEEQKQVtRSVLsYTLDNIMR----MLHPFMPFVTEKIWQSLPHQGE 700
Cdd:PRK11893 433 LAKTDPERL-ATVL-YTLLEVLRgiavLLQPVMPELAAKILDQLGVEED 479
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
39-726 |
6.49e-30 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 125.18 E-value: 6.49e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 39 IVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEAklneQGITRydlgrEKFLEQawdw 118
Cdd:TIGR00398 3 ITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKIELKAEQ----EGLTP-----KELVDK---- 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 119 keeYASFIRAQWAKLGLGLD-YSRerfTLDEGLSKAVKKVFVDLYNKGIIYRGEriinwdpkartalsdievihedVQGA 197
Cdd:TIGR00398 70 ---YHEEFKDDWKWLNISFDrFIR---TTDEEHKEIVQKIFQKLKENGYIYEKE----------------------IKQL 121
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 198 FyhfkypyadgegfieiattrpetmlgdtaivvNPNDERYkdvigktvilpivgrelpiLADEYVDidfgsgamkvtpah 277
Cdd:TIGR00398 122 Y--------------------------------CPECEMF-------------------LPDRYVE-------------- 136
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 278 dpndfeigqrhqleniivmdENGKMNDKAGKYEGMDRFDCRKQLVEDLKEQDLVIkiedhvhsvghserSGAVVEPYLST 357
Cdd:TIGR00398 137 --------------------GTCPKCGSEDARGDHCEVCGRHLEPTELINPRCKI--------------CGAKPELRDSE 182
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 358 QWFVRMEDLAKRSLDNQKTDDRIDFYPQRFEHTFNQWMEN-IRDWTISRQL-WWGHQIPawyhKETGE-IYVgeeaptdi 434
Cdd:TIGR00398 183 HYFFRLSAFEKELEEWIRKNPESGSPASNVKNKAQNWLKGgLKDLAITRDLvYWGIPVP----NDPNKvVYV-------- 250
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 435 enwqqdedvldtWFSSALWPFSTLGWPDLESEDFKRYYPTNVLVT-----GYDIIFF----WVARMIfqGLEFtdrRPFN 505
Cdd:TIGR00398 251 ------------WFDALIGYISSLGILSGDTEDWKKWWNNDEDAElihfiGKDIVRFhtiyWPAMLM--GLGL---PLPT 313
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 506 DVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDL---------RYSTEKVESVWNFINKIwn 576
Cdd:TIGR00398 314 QVFSHGYLTVE-GGKMSKSLGNVVDPSDLLARFGADILRYYLLKERPLGKDGdfswedfveRVNADLANKLGNLLNRT-- 390
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 577 garFSLMNIGEDFKVEDIDLSGNlslADKWILTRLNETIATVTDLSDKYEFGEVGRALY------NFIWDDFCDWyiEMS 650
Cdd:TIGR00398 391 ---LGFIKKYFNGVLPSEDITDE---EDKKLLKLINEALEQIDEAIESFEFRKALREIMkladrgNKYIDENKPW--ELF 462
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347494 651 KipmngNDEEQKQVtRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLphqGETIVKASWPEVRESLVFEESKQTMQQL 726
Cdd:TIGR00398 463 K-----QSPRLKEL-LAVCSMLIRVLSILLYPIMPKLSEKILKFL---NFELEWDFKLKLLEGHKLNKAEPLFSKI 529
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
565-734 |
7.72e-28 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 111.10 E-value: 7.72e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 565 ESVWNFINKIWNGARFSLMNIGEDFKVEDIDLSGNLSLA--DKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwDDF 642
Cdd:cd07961 8 EVVRKVLLPLWNAYRFFVTYANLDGFDPGKDDDAVASLNvlDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEFI-DEL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 643 CDWYIEMSKIPM-NGNDEEQKQVTRSVLSYTLDNIMRMLHPFMPFVTEKIWQSL----PHQGETIVKASWPEVRESLVFE 717
Cdd:cd07961 87 TNWYIRRNRKRFwGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLrrelGDAPESVHLLDWPEVDESLIDE 166
|
170
....*....|....*..
gi 446347494 718 ESKQTMQQLVEIIKSVR 734
Cdd:cd07961 167 ELEEAMELVREIVELGR 183
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
37-574 |
2.88e-26 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 112.00 E-value: 2.88e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 37 YTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQAKVEaklnEQGITRYDLGrekfleqaw 116
Cdd:pfam09334 1 ILVTTALPYANGPPHLGHLYSYIPADIFARYLRLRGYDVLFVCGTDEHGTPIELKAE----KEGITPEELV--------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 117 dwkEEYASFIRAQWAKLGLGLD-YSRerfTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWDPKARTALSDIEVIhedvq 195
Cdd:pfam09334 68 ---DRYHEIHREDFKKFNISFDdYGR---TTSERHHELVQEFFLKLYENGYIYEKEIEQFYCPSDERFLPDRYVE----- 136
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 196 GAFYHFKYPYADGegfieiattrpetmlgdtaivvnpnderykdvigktvilpivgrelpilaDEYvdidfgsgamkvtp 275
Cdd:pfam09334 137 GTCPHCGSEDARG--------------------------------------------------DQC-------------- 152
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 276 ahdpndfEIGQRHqleniivmdengkmndkagkYEGMDRFDCRkqlvedlkeqdlvikiedhvhsvghSERSGAVVEPYL 355
Cdd:pfam09334 153 -------ENCGRH--------------------LEPTELINPK-------------------------CVICGTTPEVKE 180
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 356 STQWFVRMEDLAKRSLDNQKTDDRIdfYPQRFEHTFNQWMEN-IRDWTISRQLWWGHQIPAwYHKETgeIYVgeeaptdi 434
Cdd:pfam09334 181 TEHYFFDLSKFQDKLREWIEENNPE--WPENVKNMVLEWLKEgLKDRAISRDLDWGIPVPG-AEGKV--FYV-------- 247
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 435 enwqqdedvldtWFSSALWPFSTLGWPDLESEDFKRYYPTN-----VLVTGYDIIFF----WVARMIFQGLEFTDRrpfn 505
Cdd:pfam09334 248 ------------WLDAPIGYISATKELSGNEEKWKEWWPNDpdtelVHFIGKDIIYFhtifWPAMLLGAGYRLPTT---- 311
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446347494 506 dVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEKvesvwnFINKI 574
Cdd:pfam09334 312 -VFAHGYLTYE-GGKMSKSRGNVVWPSEALDRFPPDALRYYLARNRPETKDTDFSWED------FVERV 372
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
32-695 |
3.14e-26 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 114.90 E-value: 3.14e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 32 KSKETYTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGiatQaKVEAKLNEQGITrydlgrekf 111
Cdd:PRK12267 1 MMKKTFYITTPIYYPNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---Q-KIQQAAEKAGKT--------- 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 112 lEQAW-DwkeEYASFIRAQWAKLGLGLDYsrerF--TLDEGLSKAVKKVFVDLYNKGIIYRGEriinwdpkartalsdie 188
Cdd:PRK12267 68 -PQEYvD---EISAGFKELWKKLDISYDK----FirTTDERHKKVVQKIFEKLYEQGDIYKGE----------------- 122
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 189 vihedvqgafYHFKYPYADGEGFieiattrPETMLGDtaivvnpnderykdvIGKTvilPIVGRELPILADE-YvdidFg 267
Cdd:PRK12267 123 ----------YEGWYCVSCETFF-------TESQLVD---------------GGKC---PDCGREVELVKEEsY----F- 162
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 268 sgamkvtpahdpndFeigqrhqleniivmdengKMndkaGKYEgmDRfdcrkqLVEDLKEQDLVIKIEdhvhsvghSERS 347
Cdd:PRK12267 163 --------------F------------------RM----SKYQ--DR------LLEYYEENPDFIQPE--------SRKN 190
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 348 ---GAVVEPYLstqwfvrmEDLAkrsldnqktddridfypqrfehtfnqwmenirdwtISRQ-LWWGHQIPaWYHKETge 423
Cdd:PRK12267 191 emiNNFIKPGL--------EDLS-----------------------------------ISRTsFDWGIPVP-FDPKHV-- 224
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 424 IYVgeeaptdienwqqdedvldtWFSSALWPFSTLGWPDLESEDFKRYYPTNVLVTGYDIIFF----WVARMIFQGLEft 499
Cdd:PRK12267 225 VYV--------------------WIDALLNYITALGYGSDDDELFKKFWPADVHLVGKDILRFhaiyWPIMLMALGLP-- 282
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 500 drrPFNDVLLHG-LVRaeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRYSTEkvesvwNFINKIwNga 578
Cdd:PRK12267 283 ---LPKKVFAHGwWLM--KDGKMSKSKGNVVDPEELVDRYGLDALRYYLLREVPFGSDGDFSPE------ALVERI-N-- 348
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 579 rFSLMN---------IGEDFKVED--IDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwdDFCDWYI 647
Cdd:PRK12267 349 -SDLANdlgnllnrtVAMINKYFDgeIPAPGNVTEFDEELIALAEETLKNYEELMEELQFSRALEEVWKLI--SRANKYI 425
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|...
gi 446347494 648 EMSKiPMN-GNDEEQKQVTRSVLsYTLDNIMR----MLHPFMPFVTEKIWQSL 695
Cdd:PRK12267 426 DETA-PWVlAKDEGKKERLATVM-YHLAESLRkvavLLSPFMPETSKKIFEQL 476
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
810-875 |
4.64e-24 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 95.80 E-value: 4.64e-24
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446347494 810 DMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRKKQDYQEKYDGVKARIEQLK 875
Cdd:pfam10458 1 DVEKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRERLSKLG 66
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
573-741 |
2.88e-23 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 97.60 E-value: 2.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 573 KIWNGARFSLMNIGEDFKVEDIDLSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIWDDFCDWYIEMSKI 652
Cdd:cd07960 15 KIRNTFRFLLGNLNDFDPAKDAVPYEELLELDRYALHRLNELIKEVREAYENYEFHKVYQALNNFCTVDLSAFYLDIIKD 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 653 PM---NGNDEEQKQVtRSVLSYTLDNIMRMLHPFMPFVTEKIWQSLPH--QGETIVKASWPEVRESLVFEESKQTMQQLV 727
Cdd:cd07960 95 RLycdAKDSLERRSA-QTVLYHILDALLKLLAPILPFTAEEVWEHLPGekKEESVFLEDWPELPEEWKDEELEEKWEKLL 173
|
170
....*....|....
gi 446347494 728 EIiksvrqsRVEVN 741
Cdd:cd07960 174 AL-------RDEVN 180
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
44-559 |
4.01e-20 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 92.21 E-value: 4.01e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 44 PNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDHAGIATQakVEAKlnEQGITRYDLGrekfleqawdwkEEYA 123
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIE--QKAE--EEGVTPQELC------------DKYH 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 124 SFIRAQWAKLGLGLD-YSRerfTLDEGLSKAVKKVFVDLYNKGIIYRGEriinwdpkartalsdievihedVQGAFyhfk 202
Cdd:cd00814 73 EIFKDLFKWLNISFDyFIR---TTSPRHKEIVQEFFKKLYENGYIYEGE----------------------YEGLY---- 123
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 203 ypyadgegfieiattrpetmlgdtaivvNPNDERYkdvigktvilpivgreLPiladeyvdidfgsgamkvtpahdpndf 282
Cdd:cd00814 124 ----------------------------CVSCERF----------------LP--------------------------- 132
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 283 eigqrhqleniivmdengkmndkagkyegmdrfdcrkqlvedlkeqdlVIKIEDHvhsvghsersgavvepylstqWFVR 362
Cdd:cd00814 133 ------------------------------------------------EWREEEH---------------------YFFR 143
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 363 MEDLAKRSLDNQKTDDRIDFyPQRFEHTFNQWMEN-IRDWTISRQLW-WGHQIPaWYHKETgeIYVGEEAP----TDIEN 436
Cdd:cd00814 144 LSKFQDRLLEWLEKNPDFIW-PENARNEVLSWLKEgLKDLSITRDLFdWGIPVP-LDPGKV--IYVWFDALigyiSATGY 219
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 437 WQQDEDvldtwfssalwpfstlgwpdlESEDFKRYYPTNVLVTGYDIIFF----WVARMIFQGLEFTDRrpfndVLLHGL 512
Cdd:cd00814 220 YNEEWG---------------------NSWWWKDGWPELVHFIGKDIIRFhaiyWPAMLLGAGLPLPTR-----IVAHGY 273
|
490 500 510 520
....*....|....*....|....*....|....*....|....*..
gi 446347494 513 VRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDLRY 559
Cdd:cd00814 274 LTVE-GKKMSKSRGNVVDPDDLLERYGADALRYYLLRERPEGKDSDF 319
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
37-557 |
4.56e-17 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 83.07 E-value: 4.56e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 37 YTIVIPPPNVTGKLHLGHAWDTTLQDIITRMKRMQGYDTLYLPGMDhagiATQAKVEAKLNEQGITRYDlgrekfleqaw 116
Cdd:cd00812 2 FYILVMFPYPSGALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAENAAIKIGRDPED----------- 66
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 117 dWKEEYASFIRAQWAKLGLGLDYSRERFTLDEGLSKAVKKVFVDLYNKGIIYRGERIINWDpkartalsdievihedvqg 196
Cdd:cd00812 67 -WTEYNIKKMKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWC------------------- 126
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 197 afyhfkypyadgegfieiattrpetmlgdtaivvnpndeRYKDvigktvilpivgrelpiladeyvdidfgsgamkvtpa 276
Cdd:cd00812 127 ---------------------------------------KLLD------------------------------------- 130
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 277 hdpndfeigqrhqleniivmdengkmndkagkyegmdrfdcrkqlvedlkeqdlvikiedhvhsvghsersgavvepyls 356
Cdd:cd00812 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 357 tQWFVR--MEDLAKRSLDNQktdDRIDFYPQRFEHTFNQWMEnirdwtISRQLWWGHQIPawyhketgeiyvgeeaptdi 434
Cdd:cd00812 131 -QWFLKysETEWKEKLLKDL---EKLDGWPEEVRAMQENWIG------CSRQRYWGTPIP-------------------- 180
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 435 enWQqdeDVLDTWFSSALWPF-------STLGWPDLESED---FKRYYPTNVLVTGYDII--------FFWVArmIFQgL 496
Cdd:cd00812 181 --WT---DTMESLSDSTWYYArytdahnLEQPYEGDLEFDreeFEYWYPVDIYIGGKEHApnhllysrFNHKA--LFD-E 252
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446347494 497 EFTDRRPFNDVLLHGLVRAEdGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSPGHDL 557
Cdd:cd00812 253 GLVTDEPPKGLIVQGMVLLE-GEKMSKSKGNVVTPDEAIKKYGADAARLYILFAAPPDADF 312
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
392-695 |
3.11e-14 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 76.73 E-value: 3.11e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 392 NQWMEN-IRDWTISRQL-WWGHQIPAwyhkETGE-IYVGEEAPtdI------ENWQQDEDvldtwfssalwpfstlgwpd 462
Cdd:PRK00133 217 KEWLEEgLQDWDISRDApYFGFEIPG----APGKvFYVWLDAP--IgyisstKNLCDKRG-------------------- 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 463 leSEDFKRYYPTN-----VLVTGYDIIF----FWVArMifqgLEFTDRRPFNDVLLHGLVRAEdGRKMSKSLGNGVDPMD 533
Cdd:PRK00133 271 --GLDWDEYWKKDsdtelYHFIGKDIIYfhtlFWPA-M----LEGAGYRLPTNVFAHGFLTVE-GAKMSKSRGTFIWART 342
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 534 VIDEYGADSLRYFLATGSSPGH---DL-------RYSTEKVESVWN-------FINKiwngaRFslmnigeDFKVEDidl 596
Cdd:PRK00133 343 YLDHLDPDYLRYYLAAKLPETIddlDFnwedfqqRVNSELVGKVVNfasrtagFINK-----RF-------DGKLPD--- 407
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 597 sgnlSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwdDFCDWYIEMSKiPMNGNDEEQKQVtRSVLSYTLD-- 674
Cdd:PRK00133 408 ----ALADPELLEEFEAAAEKIAEAYEAREFRKALREIMALA--DFANKYVDDNE-PWKLAKQDGERL-QAVCSVGLNlf 479
|
330 340
....*....|....*....|..
gi 446347494 675 -NIMRMLHPFMPFVTEKIWQSL 695
Cdd:PRK00133 480 rALAIYLKPVLPELAERAEAFL 501
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
587-695 |
6.30e-14 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 68.77 E-value: 6.30e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 587 EDFKVEDIDLsGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIWDDFcDWYIEMSKIPMNgndeeqkqvtR 666
Cdd:cd07959 21 EELIETEGEL-EELTFIDRWLLSRLNRLIKETTEAYENMQFREALKEGLYELQNDL-DWYRERGGAGMN----------K 88
|
90 100
....*....|....*....|....*....
gi 446347494 667 SVLSYTLDNIMRMLHPFMPFVTEKIWQSL 695
Cdd:cd07959 89 DLLRRFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
562-684 |
3.50e-13 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 66.76 E-value: 3.50e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 562 EKVESVWNFINKIWNGARFSLMNIGEDFKVEDidlSGNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIWDD 641
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGTQPKWD---NELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446347494 642 fcDWYIEMSKIpmNGNDEEQKQVTRSVLSYTLDNIMRMLHPFM 684
Cdd:cd07375 79 --NWYLDELKP--ALQTEELREAVLAVLRAALVVLTKLLAPFT 117
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
394-569 |
5.36e-10 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 63.19 E-value: 5.36e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 394 WMEN-IRDWTISRQLW-WGHQIPawyhketgeiyvgeeaptdienwQQDEDVLDTWFSSALWPFSTLgwpdleSEDFKRY 471
Cdd:PLN02224 260 WIKSgLRDFSISRALVdWGIPVP-----------------------DDDKQTIYVWFDALLGYISAL------TEDNKQQ 310
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 472 ---------YPTNVLVTGYDIIFF----WVARMIFQGLEFTDRrpfndVLLHGLVrAEDGRKMSKSLGNGVDPMDVIDEY 538
Cdd:PLN02224 311 nletavsfgWPASLHLIGKDILRFhavyWPAMLMSAGLELPKM-----VFGHGFL-TKDGMKMGKSLGNTLEPFELVQKF 384
|
170 180 190
....*....|....*....|....*....|.
gi 446347494 539 GADSLRYFLATGSSPGHDLRYSTEKVESVWN 569
Cdd:PLN02224 385 GPDAVRYFFLREVEFGNDGDYSEDRFIKIVN 415
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
201-325 |
4.81e-09 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 56.79 E-value: 4.81e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 201 FKYPYADGEGFIEIATTRPETMLGDTAIVVNPN--------------------------DERYKDVIGKT-------VIL 247
Cdd:pfam13603 12 ITFPVEGTDEKIEVFTTRPDTLMGVTFVALAPEhplveklaeknpevaafieeckntseIERTSETKEKEgvftglyAIH 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 248 PIVGRELPILADEYVDIDFGSGA-MKVtPAHDPNDFEIGQRHQLENIIV----------------MDENGKMNDkAGKYE 310
Cdd:pfam13603 92 PITGEKIPIWIANFVLMEYGTGAvMAV-PAHDQRDFEFAKKYNLPIKPViqpedgdldldimteaYTEEGILVN-SGEFD 169
|
170
....*....|....*
gi 446347494 311 GMDRFDCRKQLVEDL 325
Cdd:pfam13603 170 GLDSEEAKEAIIKKL 184
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
598-695 |
3.93e-07 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 49.80 E-value: 3.93e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 598 GNLSLADKWILTRLNETIATVTDLSDKYEFGEVGRALYNFIwdDFCDWYIEMSKiPMNGNDEEQKQVTRSVLsYTLDNIM 677
Cdd:cd07957 32 GGLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELA--RAANKYIDETA-PWKLAKEEDPERLATVL-YVLLELL 107
|
90 100
....*....|....*....|..
gi 446347494 678 R----MLHPFMPFVTEKIWQSL 695
Cdd:cd07957 108 RilaiLLSPFMPETAEKILDQL 129
|
|
| CysS |
COG0215 |
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA ... |
517-579 |
2.06e-06 |
|
Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Cysteinyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439985 [Multi-domain] Cd Length: 465 Bit Score: 51.26 E-value: 2.06e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446347494 517 DGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATG--SSPghdLRYSTEKVESVWNFINKIWNGAR 579
Cdd:COG0215 262 NGEKMSKSLGNFFTVRDLLKKYDPEVLRFFLLSAhyRSP---LDFSEEALEEAEKALERLYNALR 323
|
|
| CysRS_core |
cd00672 |
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) ... |
502-551 |
2.92e-05 |
|
catalytic core domain of cysteinyl tRNA synthetase; Cysteinyl tRNA synthetase (CysRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding.
Pssm-ID: 173899 [Multi-domain] Cd Length: 213 Bit Score: 46.03 E-value: 2.92e-05
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 446347494 502 RPFNDVLLH-GLVRAeDGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGS 551
Cdd:cd00672 156 KPFARYWLHtGHLTI-DGEKMSKSLGNFITVRDALKKYDPEVLRLALLSSH 205
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
488-549 |
2.25e-03 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 41.68 E-value: 2.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 488 VARMiFQGLEFTDRRPFN-DVLLH---GLVRAEDGRKMSKSLGNGVDPMDVIDE-----------------YGADSLRYF 546
Cdd:PRK01611 287 FKRL-KAALKALGYDPDAlEVLLHqmvGLVRGGEGVKMSTRAGNVVTLDDLLDEavgrarelieekeiaeaVGIDAVRYF 365
|
...
gi 446347494 547 LAT 549
Cdd:PRK01611 366 DLS 368
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
506-547 |
2.28e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 41.67 E-value: 2.28e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446347494 506 DVLLHGLVRAEDGRKMSKSLGNGVDPMDVIDEY-----------------------GADSLRYFL 547
Cdd:COG0018 365 EHLLFGMVNLRDGEKMSTRAGTVVTLDDLLDEAverareiieekseeekeeiaeqvGIDAVRYFD 429
|
|
| tRNA-synt_1e |
pfam01406 |
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA ... |
517-567 |
3.75e-03 |
|
tRNA synthetases class I (C) catalytic domain; This family includes only cysteinyl tRNA synthetases.
Pssm-ID: 396128 [Multi-domain] Cd Length: 301 Bit Score: 40.43 E-value: 3.75e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 446347494 517 DGRKMSKSLGNGVDPMDVIDEYGADSLRYFLATGSSpGHDLRYSTEKVESV 567
Cdd:pfam01406 250 DGEKMSKSLGNFFTIRDVLKRYDPEILRYFLLSVHY-RSPLDFSEELLEQA 299
|
|
| PRK03918 |
PRK03918 |
DNA double-strand break repair ATPase Rad50; |
808-875 |
3.89e-03 |
|
DNA double-strand break repair ATPase Rad50;
Pssm-ID: 235175 [Multi-domain] Cd Length: 880 Bit Score: 40.82 E-value: 3.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446347494 808 LIDMDKEISRLEKELAKLQSELDRVDKKLSNENFVSKAPEKVINEEKRK--KQDYQEKYD----------GVKARIEQLK 875
Cdd:PRK03918 607 LKDAEKELEREEKELKKLEEELDKAFEELAETEKRLEELRKELEELEKKysEEEYEELREeylelsrelaGLRAELEELE 686
|
|
| |
