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Conserved domains on  [gi|446340180|ref|WP_000418035|]
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MULTISPECIES: MarR family winged helix-turn-helix transcriptional regulator [Bacteria]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-136 1.45e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 91.57  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180   4 DNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDN 83
Cdd:COG1846    9 EERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDP 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446340180  84 ENRRTVLINSTNKAKDLWPTLEKKAYQLNNHYFANLTNEETVVFKKILLKINK 136
Cdd:COG1846   89 EDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-136 1.45e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 91.57  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180   4 DNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDN 83
Cdd:COG1846    9 EERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDP 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446340180  84 ENRRTVLINSTNKAKDLWPTLEKKAYQLNNHYFANLTNEETVVFKKILLKINK 136
Cdd:COG1846   89 EDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-123 2.21e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 82.26  E-value: 2.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180    26 LSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTLE 105
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*...
gi 446340180   106 KKAYQLNNHYFANLTNEE 123
Cdd:smart00347  83 EARSETLAELLAGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 2.60e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 49.85  E-value: 2.60e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446340180   31 ITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTV 89
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
9-134 2.55e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 41.42  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180   9 YLLSTSQNRVFKHFkslLSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRT 88
Cdd:PRK11512  19 HMVNQKKDRLLNEY---LSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRG 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446340180  89 VLINSTNKAKDLWPTLEKKAYQ-LNNHYFANLTNEETVVFKKILLKI 134
Cdd:PRK11512  96 VLVKLTTSGAAICEQCHQLVGQdLHQELTKNLTADEVATLEHLLKKV 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
4-136 1.45e-24

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 91.57  E-value: 1.45e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180   4 DNCINYLLSTSQNRVFKHFKSLLSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDN 83
Cdd:COG1846    9 EERLGLLLRRLARALRRALDRALAELGLTPAQFRVLAALAEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDP 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446340180  84 ENRRTVLINSTNKAKDLWPTLEKKAYQLNNHYFANLTNEETVVFKKILLKINK 136
Cdd:COG1846   89 EDRRAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAE 141
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
26-123 2.21e-21

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 82.26  E-value: 2.21e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180    26 LSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTLE 105
Cdd:smart00347   3 LKPLGLTPTQFLVLRILYEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQLL 82

                           90
                   ....*....|....*...
gi 446340180   106 KKAYQLNNHYFANLTNEE 123
Cdd:smart00347  83 EARSETLAELLAGLTAEE 100
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 31-89 2.60e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 49.85  E-value: 2.60e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446340180   31 ITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTV 89
Cdd:pfam01047   1 LTLTQFHILRILYEHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-87 2.85e-09

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 49.89  E-value: 2.85e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446340180   29 YNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRR 87
Cdd:pfam12802   1 LGLTPAQFRVLLALARNPGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRR 59
PRK11512 PRK11512
multiple antibiotic resistance transcriptional regulator MarR;
9-134 2.55e-05

multiple antibiotic resistance transcriptional regulator MarR;


Pssm-ID: 183170  Cd Length: 144  Bit Score: 41.42  E-value: 2.55e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180   9 YLLSTSQNRVFKHFkslLSPYNITPAEYGVLNCLINSNLNTPKAIGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRT 88
Cdd:PRK11512  19 HMVNQKKDRLLNEY---LSPLDITAAQFKVLCSIRCAACITPVELKKVLSVDLGALTRMLDRLVCKGWVERLPNPNDKRG 95

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 446340180  89 VLINSTNKAKDLWPTLEKKAYQ-LNNHYFANLTNEETVVFKKILLKI 134
Cdd:PRK11512  96 VLVKLTTSGAAICEQCHQLVGQdLHQELTKNLTADEVATLEHLLKKV 142
PRK03573 PRK03573
transcriptional regulator SlyA; Provisional
 51-136 1.91e-04

transcriptional regulator SlyA; Provisional


Pssm-ID: 179596  Cd Length: 144  Bit Score: 38.83  E-value: 1.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446340180  51 KAIGntlnLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKAKDLWPTLEKKAYQLNNHYFANLTNEETVVFKKI 130
Cdd:PRK03573  54 KAIG----IEQPSLVRTLDQLEEKGLISRQTCASDRRAKRIKLTEKAEPLISEVEAVINKTRAEILHGISAEEIEQLITL 129


                 ....*.
gi 446340180 131 LLKINK 136
Cdd:PRK03573 130 IAKLEK 135
HTH_27 pfam13463
Winged helix DNA-binding domain;
31-97 1.98e-03

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 34.57  E-value: 1.98e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446340180   31 ITPAEYGVLNCLINSNLNTPKA-IGNTLNLEPSTISGILDKMSKKDLITRQTDNENRRTVLINSTNKA 97
Cdd:pfam13463   1 LTRLEALILHNIGHRGDPKTLAdICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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