|
Name |
Accession |
Description |
Interval |
E-value |
| ValS |
COG0525 |
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase ... |
1-949 |
0e+00 |
|
Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Valyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440291 [Multi-domain] Cd Length: 877 Bit Score: 1678.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD 80
Cdd:COG0525 3 LPKTYDPKEVEAKWYQYWEENGYFKADPDSDKEPFTIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWQPGTD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 81 HAGIATQMVVERKIAaEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:COG0525 83 HAGIATQAVVERQLA-EEGKSRHDLGREKFLERVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLadgaktADGKDYLVVATTRPETLLGDTGVAVNPEDP 240
Cdd:COG0525 162 YEKGLIYRGKRLVNWDPKLKTALSDLEVEHEEVKGHLWHIRYPL------ADGSGYIVVATTRPETMLGDTAVAVHPEDE 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 241 RYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAqvfdtkgne 320
Cdd:COG0525 236 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINILDEDGTINENA--------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 321 sdvysseipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENG 400
Cdd:COG0525 307 ---------GKYRGLDRFEARKAIVADLEELGLLVKVEPHKHSVGHSDRSGTVIEPYLSDQWFVKMKPLAKPAIEAVEDG 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 401 DIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRNEDEVRKENnlgADVVLRQDEDVLDTWFSSA 480
Cdd:COG0525 378 EIKFVPERWEKTYFHWMENIRDWCISRQLWWGHRIPAWYCPDGEVYVARTEPEACAKA---GSVNLTQDEDVLDTWFSSA 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 481 LWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKdengkpQVPFHTVYMTGLIRDDEGQKMSKSKG 560
Cdd:COG0525 455 LWPFSTLGWPEKTEDLKYFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------EVPFKDVYIHGLVRDEQGRKMSKSKG 528
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 561 NVIDPLDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRN 640
Cdd:COG0525 529 NVIDPLDL-------------------------------------IDKYGADALRFTLAALASPGRDIKFDEERVEGYRN 571
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 641 FCNKLWNASRFVLMNTEGQDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELT 720
Cdd:COG0525 572 FANKLWNASRFVLMNLEGFDPGLDPDPEELSLADRWILSRLNKTIAEVTEALEKYRFDEAAQALYDFVWNEFCDWYLELA 651
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 721 KPVMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKVlcGITADTIMLQPFPQYDASQVDEAALADTEWL 800
Cdd:COG0525 652 KPRLYGGDEAAKRETRATLVYVLEQILRLLHPFMPFITEEIWQKLPP--RKEGESIMLAPWPEADEELIDEEAEAEFEWL 729
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 801 KQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAERRVNENRGFLQTLARLESITVLpADDKGPVSVTKIIDGAELLIPMA 880
Cdd:COG0525 730 KEVISAIRNIRAEMNIPPSKKLPLLLKGADEADRARLEENAAYIKRLARLEEITIL-VDEKPEGAASAVVGGAEVFLPLE 808
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446338537 881 GLINKEDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLEGYAEAKAKLIEQQAVIA 949
Cdd:COG0525 809 GLIDVEAERARLEKELAKLEKEIARVEKKLSNEGFVAKAPAEVVEKEREKLAEAEAKLEKLEEQLARLK 877
|
|
| valS |
PRK05729 |
valyl-tRNA synthetase; Reviewed |
1-950 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 235582 [Multi-domain] Cd Length: 874 Bit Score: 1621.33 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNgDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD 80
Cdd:PRK05729 5 LPKTYDPKEVEAKWYQKWEEKGYFKPD-DNSKKPFSIVIPPPNVTGSLHMGHALNNTLQDILIRYKRMQGYNTLWLPGTD 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 81 HAGIATQMVVERKIAAEeGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:PRK05729 84 HAGIATQMVVERQLAAE-GKSRHDLGREKFLEKVWEWKEESGGTITNQLRRLGASCDWSRERFTMDEGLSKAVREVFVRL 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGaktadgKDYLVVATTRPETLLGDTGVAVNPEDP 240
Cdd:PRK05729 163 YEKGLIYRGKRLVNWDPKLQTALSDLEVEYKEVKGKLWHIRYPLADG------SDYLVVATTRPETMLGDTAVAVNPEDE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 241 RYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESaqvfdtkgne 320
Cdd:PRK05729 237 RYKHLIGKTVILPLVGREIPIIADEYVDPEFGTGAVKITPAHDPNDFEVGKRHNLPMINIMDEDGTINEN---------- 306
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 321 sdvysseiPAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENG 400
Cdd:PRK05729 307 --------PGEYQGLDRFEARKAIVADLEELGLLVKIEPHTHSVGHSDRSGVVIEPYLSDQWFVKMKPLAKPALEAVENG 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 401 DIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRNEDEVRKENNlgadvvLRQDEDVLDTWFSSA 480
Cdd:PRK05729 379 EIKFVPERWEKTYFHWMENIQDWCISRQLWWGHRIPAWYDEDGEVYVGREEPEAREKAL------LTQDEDVLDTWFSSA 452
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 481 LWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKdengkpQVPFHTVYMTGLIRDDEGQKMSKSKG 560
Cdd:PRK05729 453 LWPFSTLGWPEKTEDLKRFYPTSVLVTGFDIIFFWVARMIMMGLHFTG------QVPFKDVYIHGLVRDEQGRKMSKSKG 526
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 561 NVIDPLDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRN 640
Cdd:PRK05729 527 NVIDPLDL-------------------------------------IDKYGADALRFTLAALASPGRDIRFDEERVEGYRN 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 641 FCNKLWNASRFVLMNTEGQDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELT 720
Cdd:PRK05729 570 FANKLWNASRFVLMNLEGADVGELPDPEELSLADRWILSRLNRTVAEVTEALDKYRFDEAARALYEFIWNEFCDWYLELA 649
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 721 KPVMNggtEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKVLCGitADTIMLQPFPQYDASQvDEAALADTEWL 800
Cdd:PRK05729 650 KPVLQ---EAAKRATRATLAYVLEQILRLLHPFMPFITEELWQKLAPLGI--EESIMLAPWPEADEAI-DEAAEAEFEWL 723
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 801 KQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAERRVNENRGFLQTLARLESITVLPADDKGPV-SVTKIIDGAELLIPM 879
Cdd:PRK05729 724 KELITAIRNIRAEMNIPPSKKLPLLLKGADAEDRARLEANEAYIKRLARLESLEILADDEEAPEgAASAVVGGAELFLPL 803
|
890 900 910 920 930 940 950
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446338537 880 AGLINKEDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLEGYAEAKAKLIEQQAVIAA 950
Cdd:PRK05729 804 EGLIDVEAELARLEKELAKLEKEIERVEKKLSNEGFVAKAPEEVVEKEREKLAEYEEKLAKLKERLARLKA 874
|
|
| valS |
TIGR00422 |
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase ... |
1-932 |
0e+00 |
|
valyl-tRNA synthetase; The valyl-tRNA synthetase (ValS) is a class I amino acyl-tRNA ligase and is particularly closely related to the isoleucyl tRNA synthetase. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273070 [Multi-domain] Cd Length: 861 Bit Score: 1412.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD 80
Cdd:TIGR00422 1 MPKDYDPHEVEKKWYKKWEKSGFFKPDGNSNKPPFCIDIPPPNVTGSLHIGHALNWSIQDIIARYKRMKGYNVLWLPGTD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 81 HAGIATQMVVERKIAAEeGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:TIGR00422 81 HAGIATQVKVEKKLGAE-GKTKHDLGREEFREKIWEWKEESGGTIKNQIKRLGASLDWSRERFTMDEGLSKAVKEAFVRL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAktadgKDYLVVATTRPETLLGDTGVAVNPEDP 240
Cdd:TIGR00422 160 YEKGLIYRGEYLVNWDPKLNTAISDIEVEYKEVKGKLYYIRYPLANGS-----KDYLVVATTRPETMFGDTAVAVHPEDE 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 241 RYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAqvfdtkgne 320
Cdd:TIGR00422 235 RYKHLIGKKVILPLTGRKIPIIADEYVDMEFGTGAVKVTPAHDFNDYEWGKRHNLEFINILDEDGLLNENA--------- 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 321 sdvysseipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENG 400
Cdd:TIGR00422 306 ---------GKYQGLTRFEARKKIVEDLKEEGLLVKIEPHTHNVGTCWRSGTVVEPLLSKQWFVKVEKLADKALEAAEEG 376
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 401 DIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-DEAGNVYVGRNEDEVRKENNLGADVVLRQDEDVLDTWFSS 479
Cdd:TIGR00422 377 EIKFVPKRMEKRYLNWLRNIKDWCISRQLIWGHRIPVWYcKECGEVYVAKEEPLPDDKTNTGPSVELEQDTDVLDTWFSS 456
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 480 ALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKdengkpQVPFHTVYMTGLIRDDEGQKMSKSK 559
Cdd:TIGR00422 457 SLWPFSTLGWPDETKDLKKFYPTDLLVTGYDIIFFWVARMIFRSLALTG------QVPFKEVYIHGLVRDEQGRKMSKSL 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 560 GNVIDPLDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAALASTGRDINWDMKRLEGYR 639
Cdd:TIGR00422 531 GNVIDPLDV-------------------------------------IEKYGADALRFTLASLVTPGDDINFDWKRVESAR 573
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 640 NFCNKLWNASRFVLMNTEGqDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLEL 719
Cdd:TIGR00422 574 NFLNKLWNASRFVLMNLSD-DLELSGGEEKLSLADRWILSKLNRTIKEVRKALDKYRFAEAAKALYEFIWNDFCDWYIEL 652
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 720 TKPVMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKvlcgITADTIMLQPFPQYDASQVDEAALADTEW 799
Cdd:TIGR00422 653 VKYRLYNGNEAEKKAARDTLYYVLDKALRLLHPFMPFITEEIWQHFK----EGADSIMLQSYPVVDAEFVDEEAEKAFEL 728
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 800 LKQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAERRVNENRGFLQTLARLESITVLPADDKGPVSVTKIIDGAELLIPM 879
Cdd:TIGR00422 729 LKEIIVSIRNLKAESNIPPNAPLKVLLIYTEAETAERLKLNAVDIKGAINFSEVEVVIEKPEVTEAVVELVPGFEIIIPV 808
|
890 900 910 920 930
....*....|....*....|....*....|....*....|....*....|...
gi 446338537 880 AGLINKEDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLE 932
Cdd:TIGR00422 809 KGLINKAKELARLQKQLDKEKKEVIRIEGKLENEGFVKKAPKEVIEKEKEKLE 861
|
|
| PTZ00419 |
PTZ00419 |
valyl-tRNA synthetase-like protein; Provisional |
1-945 |
0e+00 |
|
valyl-tRNA synthetase-like protein; Provisional
Pssm-ID: 240411 [Multi-domain] Cd Length: 995 Bit Score: 1025.71 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDE----SQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQ 76
Cdd:PTZ00419 24 MAASYDPKEVESGWYEWWEKSGFFKPAEDAkslnSGKKFVIVLPPPNVTGYLHIGHALTGAIQDSLIRYHRMKGDETLWV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 77 VGTDHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEV 156
Cdd:PTZ00419 104 PGTDHAGIATQVVVEKKLMKEENKTRHDLGREEFLKKVWEWKDKHGNNICNQLRRLGSSLDWSREVFTMDEQRSKAVKEA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 157 FVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESK----------------GSMWHIRYPLADGaktadGKDYLVVA 220
Cdd:PTZ00419 184 FVRLYEDGLIYRDTRLVNWCCYLKTAISDIEVEFEEIEkptkitipgydkkvevGVLWHFAYPLEDS-----GQEEIVVA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 221 TTRPETLLGDTGVAVNPEDPRYKDLIGKYVILPLVN-RRIPIVGDE-HADMEKGTGCVKITPAHDFNDYEVGKRHALPMI 298
Cdd:PTZ00419 259 TTRIETMLGDVAVAVHPKDERYKKLHGKELIHPFIPdRKIPIIADDeLVDMEFGTGAVKITPAHDPNDYEIAKRHNLPFI 338
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 299 NILTFDGDIRESAqvfdtkgnesdvysseipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPML 378
Cdd:PTZ00419 339 NIFTLDGKINENG------------------GEFAGMHRFDCRRKIEEELKEMGLLRDKVPNPMRLPRCSRSGDIVEPML 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 379 TDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAW-----------YDEAGNVyV 447
Cdd:PTZ00419 401 IPQWYVNCKDMAKRAVEAVRNGELKIIPSSHENVWYHWLENIQDWCISRQLWWGHRIPAYrviskgpetdpSDEEPWV-V 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 448 GRNEDEVRKE-----NNLGADVVLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMM 522
Cdd:PTZ00419 480 ARSEEEALEKakkkfGLSEEDFELEQDEDVLDTWFSSGLFPFSTLGWPDQTDDLQRFFPTSLLETGSDILFFWVARMVMM 559
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 523 TMHFIKdengkpQVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGISLPELLEK-RTGNMMQpqlaDKIRKRTE-- 599
Cdd:PTZ00419 560 SLHLTD------KLPFKTVFLHAMVRDSQGEKMSKSKGNVIDPLEVIEGISLQDLNQKlYEGNLPE----KEIKRAIElq 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 600 -KQFPNGIEPHGTDALRFTLAALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEGQD----CGFNGGEM--TLSL 672
Cdd:PTZ00419 630 kKEFPNGIPECGTDALRFGLLAYTQQGRNINLDINRVVGYRHFCNKLWNAVKFALMKLLKDFnlpnSTLFKPNNveSLPW 709
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 673 ADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGTEAELR-GTRHTLVTVLEGLLRLAH 751
Cdd:PTZ00419 710 EDKWILHRLNVAIKEVTEGFKEYDFSEATQATYNFWLYELCDVYLELIKPRLSKQSDGERKqHAQDVLHTVLDIGLRLLH 789
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 752 PIIPFITETIWQRV-KVLCGItaDTIMLQPFPQYDASQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGCS 830
Cdd:PTZ00419 790 PMMPFITEELYQRLpNYLRKS--ESISIAKYPQPNPGWNNEALDEEMKIIMSIVKSIRSLIATLGIPNKTKPDCYVTAKD 867
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 831 ADAERRVNENRGFLQTLARLESITVLPADDKG---PVSVTKIIDGAELLIPM--AGLINKEDELARLAKEVAKIEGEISR 905
Cdd:PTZ00419 868 AELIELIESAENLISTLAKIGSVSVIPPIEEEaevPKGCGFDVVDNKVIIYLnlDEFIDLKKELAKLEKKLAKLQKSLES 947
|
970 980 990 1000
....*....|....*....|....*....|....*....|
gi 446338537 906 IENKLANEGFVARAPEAVIAKEREKLEGYAEAKaKLIEQQ 945
Cdd:PTZ00419 948 YLKKISIPNYEDKVPEDVRKLNDEKIDELNEEI-KQLEQA 986
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
1-949 |
0e+00 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 998.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPN-GDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGT 79
Cdd:PRK14900 15 LAKGYEHREVEARWYPFWQERGYFHGDeHDRTRPPFSIVLPPPNVTGSLHLGHALTATLQDVLIRWKRMSGFNTLWLPGT 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 80 DHAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVR 159
Cdd:PRK14900 95 DHAGIATQMIVEKELKKTEKKSRHDLGREAFLERVWAWKEQYGSRIGEQHKALGASLDWQRERFTMDEGLSRAVREVFVR 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 160 LYKEDLIYRGKRLVNWDPKLRTAISDLEVENRESK-GSMWHIRYPLADGAKTadgkdyLVVATTRPETLLGDTGVAVNPE 238
Cdd:PRK14900 175 LHEEGLIYREKKLINWCPDCRTALSDLEVEHEEAHqGELWSFAYPLADGSGE------IVVATTRPETMLGDTAVAVHPL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 239 DPRYKDLIGKYVILPLVNRRIPIVGD-EHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAqvfdtk 317
Cdd:PRK14900 249 DPRYMALHGKKVRHPITGRTFPIVADaILVDPKFGTGAVKVTPAHDFNDFEVGKRHGLEMITVIGPDGRMTAEA------ 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 318 gnesdvysseipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAV 397
Cdd:PRK14900 323 ------------GPLAGLDRFEARKEVKRLLAEQGLDRGAKPHVLPLGRCQRSATILEPLLSDQWYVRIEPLARPAIEAV 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 398 ENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRnedEVRKENNLGADVVLRQDEDVLDTWF 477
Cdd:PRK14900 391 EQGRTRFIPEQWTNTYMAWMRNIHDWCISRQLWWGHQIPAWYCPDGHVTVAR---ETPEACSTCGKAELRQDEDVLDTWF 467
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 478 SSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFIKDengkpqVPFHTVYMTGLIRDDEGQKMSK 557
Cdd:PRK14900 468 SSGLWPFSTMGWPEQTDTLRTFYPTSVMETGHDIIFFWVARMMMMGLHFMGE------VPFRTVYLHPMVRDEKGQKMSK 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 558 SKGNVIDPLDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAALASTGRDINWDMKRLEG 637
Cdd:PRK14900 542 TKGNVIDPLVI-------------------------------------TEQYGADALRFTLAALTAQGRDIKLAKERIEG 584
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 638 YRNFCNKLWNASRFVLMNTEG-QDCGFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWY 716
Cdd:PRK14900 585 YRAFANKLWNASRFALMNLSGyQERGEDPARLARTPADRWILARLQRAVNETVEALEAFRFNDAANAVYAFVWHELCDWY 664
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 717 LELTKPVMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQ--RVKVLCGITADTIMLQPFPQYDAsqVDEAAL 794
Cdd:PRK14900 665 IELAKEALASEDPEARRSVQAVLVHCLQTSYRLLHPFMPFITEELWHvlRAQVGASAWADSVLAAEYPRKGE--ADEAAE 742
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 795 ADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRG--CSADAERRVNENRGFLQTLARLESIT-----VLPADDKGPVSVT 867
Cdd:PRK14900 743 AAFRPVLGIIDAVRNIRGEMGIPWKVKLGAQAPVeiAVADPALRDLLQAGELARVHRVAGVEgsrlvVAAATAPAPQSAV 822
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 868 KIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLEGYAEAKAKLIEQQAV 947
Cdd:PRK14900 823 GVGPGFEVRVPLAGVIDLAAETARVDKEIGKVDQDLAVLERKLQNPSFVQNAPPAVVEKDRARAEELREKRGKLEAHRAM 902
|
..
gi 446338537 948 IA 949
Cdd:PRK14900 903 LS 904
|
|
| PLN02943 |
PLN02943 |
aminoacyl-tRNA ligase |
11-945 |
0e+00 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215509 [Multi-domain] Cd Length: 958 Bit Score: 804.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 11 EQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVV 90
Cdd:PLN02943 66 EERIYNWWESQGYFKPNFDRGGDPFVIPMPPPNVTGSLHMGHAMFVTLEDIMVRYNRMKGRPTLWIPGTDHAGIATQLVV 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 91 ERKIAAEeGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:PLN02943 146 EKMLASE-GIKRTDLGRDEFTKRVWEWKEKYGGTITNQIKRLGASCDWSRERFTLDEQLSRAVVEAFVRLHEKGLIYQGS 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 171 RLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKtadgkDYLVVATTRPETLLGDTGVAVNPEDPRYKDLIGKYV 250
Cdd:PLN02943 225 YMVNWSPNLQTAVSDLEVEYSEEPGTLYYIKYRVAGGSE-----DFLTIATTRPETLFGDVAIAVNPEDDRYSKYIGKMA 299
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 251 ILPLV-NRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAQVFdtkgnesdvysseip 329
Cdd:PLN02943 300 IVPMTyGRHVPIIADRYVDKDFGTGVLKISPGHDHNDYLLARKLGLPILNVMNKDGTLNEVAGLY--------------- 364
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 330 aefqkleRFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFVPKQY 409
Cdd:PLN02943 365 -------WFEAREKLWSDLEETGLAVKKEPHTLRVPRSQRGGEVIEPLVSKQWFVTMEPLAEKALKAVENGELTIIPERF 437
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 410 ENMYFSWMRDIQDWCISRQLWWGHRIPAWY----DEAGNVYVGRNEDEV--RKENNLGADVVLRQDEDVLDTWFSSALWT 483
Cdd:PLN02943 438 EKIYNHWLSNIKDWCISRQLWWGHRIPVWYivgkDCEEDYIVARSAEEAleKAREKYGKDVEIYQDPDVLDTWFSSALWP 517
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 484 FSTLGWPE-NTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMHFikdeNGKpqVPFHTVYMTGLIRDDEGQKMSKSKGNV 562
Cdd:PLN02943 518 FSTLGWPDvSAEDFKKFYPTTVLETGHDILFFWVARMVMMGIEF----TGT--VPFSYVYLHGLIRDSQGRKMSKTLGNV 591
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 563 IDPLDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAaLASTGRDINWDMKRLEGYRNFC 642
Cdd:PLN02943 592 IDPLDT-------------------------------------IKEFGTDALRFTLA-LGTAGQDLNLSTERLTSNKAFT 633
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 643 NKLWNASRFVLMNTEGQ----------DCGFNGGE--MTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWN 710
Cdd:PLN02943 634 NKLWNAGKFVLQNLPSQsdtsawehilACKFDKEEslLSLPLPECWVVSKLHELIDSVTTSYDKYFFGDVGREIYDFFWS 713
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 711 QFCDWYLELTKPVM--NGGTEAELRgTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKVlcgiTADTIMLQPFPQYDASQ 788
Cdd:PLN02943 714 DFADWYIEASKTRLyhSGDNSALSR-AQAVLLYVFENILKLLHPFMPFVTEELWQALPY----RKEALIVSPWPQTSLPK 788
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 789 vDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGcSADAERRVNENRGFLQTLARLESITV-----LPADDKGP 863
Cdd:PLN02943 789 -DLKSIKRFENLQSLTRAIRNARAEYSVEPAKRISASIVA-SAEVIEYISKEKEVLALLSRLDLQNVhftdsPPGDANQS 866
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 864 VSVTkIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLEgYAEAKAKLIE 943
Cdd:PLN02943 867 VHLV-ASEGLEAYLPLADMVDISAEVERLSKRLSKMQTEYDALAARLSSPKFVEKAPEDVVRGVREKAA-EAEEKIKLTK 944
|
..
gi 446338537 944 QQ 945
Cdd:PLN02943 945 NR 946
|
|
| tRNA-synt_1 |
pfam00133 |
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too ... |
13-631 |
0e+00 |
|
tRNA synthetases class I (I, L, M and V); Other tRNA synthetase sub-families are too dissimilar to be included.
Pssm-ID: 459685 [Multi-domain] Cd Length: 602 Bit Score: 801.63 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 13 PLYEHWEKQGYFKPN--GDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVV 90
Cdd:pfam00133 1 QIYEFWDEQGYFKPEleKRKGKPSFTIHDGPPNATGSLHIGHALAKTLKDIVIRYKRMKGYYVLWVPGWDHHGLPTEQVV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 91 ERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:pfam00133 81 EKKLGIKEKKTRHKYGREEFREKCREWKMEYADEIRKQFRRLGRSIDWDREYFTMDPELEAAVWEVFVRLHDKGLIYRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 171 RLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGAKTadgkdYLVVATTRPETLLGDTGVAVNPE------------ 238
Cdd:pfam00133 161 KLVNWSPALNTALSNLEVEYKDVKGPSIHVAFPLADDEGA-----SLVIWTTTPWTLPGNTAVAVNPEfdyvitgegyil 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 239 -------------------DPRYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMIN 299
Cdd:pfam00133 236 aeallkslykkgtdkkileDFRGKELEGKEAIHPFVNREIPIITDDYVDMEFGTGAVHIAPAHGENDYEVGQRHNLEVIN 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 300 ILTFDGDIRESAqvfdtkgnesdvysseipAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLT 379
Cdd:pfam00133 316 PVDDDGTFTEEA------------------PDFQGVYRFDARKKIVELLTEKGLLLKIEPFTHSYPFCWRSGTPIIPRAT 377
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 380 DQWYVRADVLAKPAVEAVENgdIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEA-GNVYV---------GR 449
Cdd:pfam00133 378 PQWFVRMDELADQALEAVEK--VQFVPKSGEKRYFNWLANIQDWCISRQRWWGHPIPAWVSKDtEEVVCrgelfelvaGR 455
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 450 NEDEVRKENNL---------GADvVLRQDEDVLDTWFSSALWTFSTLGWPE-NTDALRQFHPTSVMVSGFDIIFFWIARM 519
Cdd:pfam00133 456 FEEEGSIKWLHreakdklgyGKG-TLEQDEDVLDTWFSSGSWPFSTLGWPFvNTEEFKKFFPADMLLEGSDQTRGWFYRM 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 520 IMMTMHFIKDengkpqVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDgislpellekrtgnmmqpqladkirkrte 599
Cdd:pfam00133 535 IMLSTALTGS------VPFKNVLVHGLVRDEQGRKMSKSLGNVIDPLDVID----------------------------- 579
|
650 660 670
....*....|....*....|....*....|..
gi 446338537 600 kqfpngiePHGTDALRFTLaALASTGRDINWD 631
Cdd:pfam00133 580 --------KYGADALRLWL-ANSDYGRDINLS 602
|
|
| PLN02381 |
PLN02381 |
valyl-tRNA synthetase |
1-948 |
0e+00 |
|
valyl-tRNA synthetase
Pssm-ID: 215214 [Multi-domain] Cd Length: 1066 Bit Score: 782.16 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD 80
Cdd:PLN02381 96 MAKQYSPSAVEKSWYAWWEKSGYFGADAKSSKPPFVIVLPPPNVTGALHIGHALTAAIEDTIIRWKRMSGYNALWVPGVD 175
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 81 HAGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:PLN02381 176 HAGIATQVVVEKKLMRERHLTRHDIGREEFVSEVWKWKDEYGGTILNQLRRLGASLDWSRECFTMDEQRSKAVTEAFVRL 255
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESK----------------GSMWHIRYPLADGAKTadgkdyLVVATTRP 224
Cdd:PLN02381 256 YKEGLIYRDIRLVNWDCTLRTAISDVEVDYIDIKertllkvpgydkpvefGVLTSFAYPLEGGLGE------IVVATTRI 329
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 225 ETLLGDTGVAVNPEDPRYKDLIGKYVILPLVNRRIPIVGD-EHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTF 303
Cdd:PLN02381 330 ETMLGDTAIAIHPDDERYKHLHGKFAVHPFNGRKLPIICDaILVDPNFGTGAVKITPAHDPNDFEVGKRHNLEFINIFTD 409
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 304 DGDIresaqvfdtkgnesdvySSEIPAEFQKLERFAARKAVVAAVDALGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWY 383
Cdd:PLN02381 410 DGKI-----------------NSNGGSEFAGMPRFAAREAVIEALQKKGLYRGAKNNEMRLGLCSRTNDVVEPMIKPQWF 472
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 384 VRADVLAKPAVEAV---ENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-----DEAGNV-------YVG 448
Cdd:PLN02381 473 VNCSSMAKQALDAAidgENKKLEFIPKQYLAEWKRWLENIRDWCISRQLWWGHRIPAWYvtledDQLKELgsyndhwVVA 552
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 449 RNEDEVRKENN---LGADVVLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWIARMIMMTMH 525
Cdd:PLN02381 553 RNESDALLEASqkfPGKKFELSQDPDVLDTWFSSGLFPLSVLGWPDDTDDLKAFYPTSVLETGHDILFFWVARMVMMGMQ 632
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 526 FIKDengkpqVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGISLPELLEKRTGNMMQPQLADKIRKRTEKQFPNG 605
Cdd:PLN02381 633 LGGD------VPFRKVYLHPMIRDAHGRKMSKSLGNVIDPLEVINGISLEGLHKRLEEGNLDPKELVVAKEGQKKDFPNG 706
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 606 IEPHGTDALRFTLAALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTegqDCGFNgGEMTLSLAD-----RWILAE 680
Cdd:PLN02381 707 IAECGTDALRFALVSYTAQSDKINLDILRVVGYRQWCNKLWNAVRFAMSKL---GDDYT-PPATLSVETmpfscKWILSV 782
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 681 FNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELTKPVMNGGT---EAELRGTRHTLVTVLEGLLRLAHPIIPFI 757
Cdd:PLN02381 783 LNKAISKTVSSLDAYEFSDAASTVYSWWQYQFCDVFIEAIKPYFAGDNpefASERAAAQDTLWICLDTGLRLLHPFMPFV 862
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 758 TETIWQRVKVLCGIT-ADTIMLQPFPQYDASQVDEAALADTEWLKQAIVAVRNIRAEmnIAPGKPLELL--LRGCSADAE 834
Cdd:PLN02381 863 TEELWQRLPQPKDHTrKDSIMISEYPSAVEAWTNEKVEYEMDLVLSTVKCLRSLRAE--VLEKQKNERLpaFALCRNQEI 940
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 835 RRVNENRGFL-QTLARLESITVLPADDKGP---VSVTKIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEISRIENKL 910
Cdd:PLN02381 941 AAIIKSHQLEiLTLANLSSLKVLLSENDAPpagCAFENVNENLKVYLQAQGAVNAEAELEKLRNKMDEIQKQQEKLEKKM 1020
|
970 980 990
....*....|....*....|....*....|....*...
gi 446338537 911 ANEGFVARAPEAVIAKEREKLegyaeakAKLIEQQAVI 948
Cdd:PLN02381 1021 NASGYKEKVPANIQEEDARKL-------TKLLQELEFF 1051
|
|
| ValRS_core |
cd00817 |
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) ... |
33-630 |
0e+00 |
|
catalytic core domain of valyl-tRNA synthetases; Valine amino-acyl tRNA synthetase (ValRS) catalytic core domain. This enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. ValRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 185677 [Multi-domain] Cd Length: 382 Bit Score: 575.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 33 ESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVVERKIAAEeGKTRHDYGREAFID 112
Cdd:cd00817 1 PVFVIDTPPPNVTGSLHMGHALNNTIQDIIARYKRMKGYNVLWPPGTDHAGIATQVVVEKKLGIE-GKTRHDLGREEFLE 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 113 KIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVenre 192
Cdd:cd00817 80 KCWEWKEESGGKIREQLKRLGASVDWSREYFTMDPGLSRAVQEAFVRLYEKGLIYRDNRLVNWCPKLRTAISDIEV---- 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 193 skgsmwhirypladgaktadgkdylvvattrpetllgdtgvavnpedprykdligkyvilplvnrripivgdehadmekg 272
Cdd:cd00817 --------------------------------------------------------------------------------
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 273 tgcvkitpahdfndyevgkrhalpminiltfdgdiresaqvfdtkgnesdvysseipaefqklerfaarkavvaavdalg 352
Cdd:cd00817 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 353 lleeikphdltvpyGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRDIQDWCISRQLWWG 432
Cdd:cd00817 156 --------------CSRSGDVIEPLLKPQWFVKVKDLAKKALEAVKEGDIKFVPERMEKRYENWLENIRDWCISRQLWWG 221
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 433 HRIPAWYDEAGN-VYVGRNEDEVR-----KENNLGADVVLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMV 506
Cdd:cd00817 222 HRIPAWYCKDGGhWVVAREEDEAIdkaapEACVPCGGEELKQDEDVLDTWFSSSLWPFSTLGWPEETKDLKKFYPTSLLV 301
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 507 SGFDIIFFWIARMIMMTMHFIKdengkpQVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGIslpellekrtgnmm 586
Cdd:cd00817 302 TGHDIIFFWVARMIMRGLKLTG------KLPFKEVYLHGLVRDEDGRKMSKSLGNVIDPLDVIDGY-------------- 361
|
570 580 590 600
....*....|....*....|....*....|....*....|....
gi 446338537 587 qpqladkirkrtekqfpngiephGTDALRFTLAALASTGRDINW 630
Cdd:cd00817 362 -----------------------GADALRFTLASAATQGRDINL 382
|
|
| valS |
PRK13208 |
valyl-tRNA synthetase; Reviewed |
1-867 |
0e+00 |
|
valyl-tRNA synthetase; Reviewed
Pssm-ID: 237306 [Multi-domain] Cd Length: 800 Bit Score: 544.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD 80
Cdd:PRK13208 6 LPKKYDPEELEEKWQKIWEEEGTYKFDPDERKPVYSIDTPPPTVSGSLHIGHVFSYTHTDFIARYQRMRGYNVFFPQGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 81 HAGIATqmvvERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRL 160
Cdd:PRK13208 86 DNGLPT----ERKVEKYYGIRKDDISREEFIELCRELTDEDEKKFRELWRRLGLSVDWSLEYQTISPEYRRISQKSFLDL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 161 YKEDLIYRGKRLVNWDPKLRTAISDLEVENRESKGSMWHIRYPLADGaktadgkDYLVVATTRPEtLLGDT-GVAVNPED 239
Cdd:PRK13208 162 YKKGLIYRAEAPVLWCPRCETAIAQAEVEYREREGKLNYIKFPVEDG-------EEIEIATTRPE-LLPACvAVVVHPDD 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 240 PRYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAQVFDTKGN 319
Cdd:PRK13208 234 ERYKHLVGKTAIVPLFGVEVPILADPLVDPDFGTGAVMICTFGDKTDVTWWRELNLPTRIIIDEDGRMTEAAGKLAGLTI 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 320 ESdvySSEIPAEfqKLERfaarkavvaavdaLGLLEEIKPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVEn 399
Cdd:PRK13208 314 EE---ARKKIVE--DLKS-------------GGLLGKQEPIKHNVKFCERCDTPLEILVTRQWFIKVLDLKEELLERGK- 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 400 gDIQFVP----KQYENmyfsWMRDIQ-DWCISRQLWWGHRIPAWY-DEAGNVYVGRNED----------EVRKENNLGAD 463
Cdd:PRK13208 375 -EINWYPehmrVRLEN----WIEGLNwDWCISRQRYFGTPIPVWYcKDCGHPILPDEEDlpvdptkdepPGYKCPQCGSP 449
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 464 VvLRQDEDVLDTWFSSAL-WTFSTlGWPENTDALRQFHPTSVMVSGFDIIFFW----IARMIMmtmhfikdENGKpqVPF 538
Cdd:PRK13208 450 G-FEGETDVMDTWATSSItPLIVT-GWERDEDLFEKVFPMDLRPQGHDIIRTWlfytILRAYL--------LTGK--LPW 517
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 539 HTVYMTGLIRDDEGQKMSKSKGNVIDPLdmvdgislpELLEKrtgnmmqpqladkirkrtekqfpngiepHGTDALRFTl 618
Cdd:PRK13208 518 KNIMISGMVLDPDGKKMSKSKGNVVTPE---------ELLEK----------------------------YGADAVRYW- 559
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 619 AALASTGRDINWDMKRLEGYRNFCNKLWNASRFVLMNTEGQDcgfNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFD 698
Cdd:PRK13208 560 AASARLGSDTPFDEKQVKIGRRLLTKLWNASRFVLHFSADPE---PDKAEVLEPLDRWILAKLAKVVEKATEALENYDFA 636
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 699 IAAGILYEFTWNQFCDWYLELTKP-VMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRvkvlcgITADTIM 777
Cdd:PRK13208 637 KALEEIESFFWHVFCDDYLELVKSrAYGEDEEEEQKSARYTLYTVLDTLLRLLAPFLPFITEEVWSW------LYGGSVH 710
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 778 LQPFPQYDASQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLLRGCSADAErRVNENRGFLQTLARLESITVLP 857
Cdd:PRK13208 711 RASWPEPDEELIDEEDEELGELAKEILSAVRKYKSEAGLSLNAPLKKVEVYGPADLE-LLEAAEEDLKAAGNIEELELVE 789
|
890
....*....|
gi 446338537 858 ADDKGPVSVT 867
Cdd:PRK13208 790 GDPELEVEII 799
|
|
| IleS |
COG0060 |
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA ... |
41-877 |
3.81e-94 |
|
Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Isoleucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439830 [Multi-domain] Cd Length: 931 Bit Score: 318.56 E-value: 3.81e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 41 PPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD-HaGiatqMVVERKIAAEEGKTR---HDYGREAFIDK--- 113
Cdd:COG0060 54 PPYANGDIHIGHALNKILKDIIVRYKTMRGFDVPYVPGWDcH-G----LPIELKVEKELGIKKkdiEKVGIAEFREKcre 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 114 -IWEWKAEsggtITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEVE--N 190
Cdd:COG0060 129 yALKYVDE----QREDFKRLGVWGDWDNPYLTMDPEYEESIWWALKKLYEKGLLYKGLKPVPWCPRCGTALAEAEVEykD 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 191 RESKgSMWhIRYPLADGAKTADGKD-YLVVATTRPETLLGDTGVAVNPE---------DPRY----KDL---------IG 247
Cdd:COG0060 205 VTSP-SIY-VKFPVKDEKALLLLEDaYLVIWTTTPWTLPANLAVAVHPDidyvlvevtGGERlilaEALveavlkelgIE 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 248 KYVIL---------------PL-----VNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDI 307
Cdd:COG0060 283 DYEVLatfkgaeleglryehPFyyvvgYDRAHPVILGDYVTTEDGTGIVHTAPGHGEDDFEVGKKYGLPVLNPVDDDGRF 362
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 308 RESA------QVFDTkgNEsdvyssEIpaeFQKL-ERfaarkavvaavdalGLL---EEIK---PHDL---Tvpygdrgg 371
Cdd:COG0060 363 TEEAplfaglFVKDA--NP------AI---IEDLkER--------------GALlarEKIThsyPHCWrckT-------- 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 372 vviePML---TDQWYVRADVLAKPAVEAVEngDIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWY-DEAGNVY- 446
Cdd:COG0060 410 ----PLIyraTPQWFISMDKLRDRALEAIE--KVNWIPEWGEGRFGNMLENRPDWCISRQRYWGVPIPIWVcEDCGELHr 483
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 447 ----VGRNEDEVRKEnnlGADV----------------------VLRQDEDVLDTWF-SSALWtFSTLgwpENTDALRqf 499
Cdd:COG0060 484 teevIGSVAELLEEE---GADAwfeldlhrpfldetlkcpkcggTMRRVPDVLDVWFdSGSMH-FAVL---ENREELH-- 554
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 500 hptsvmvsgfdiiffWIARMIM----------MTMHFI----KDengkpQVPFHTVYMTGLIRDDEGQKMSKSKGNVIDP 565
Cdd:COG0060 555 ---------------FPADFYLegsdqtrgwfYSSLLTstalFG-----RAPYKNVLTHGFVLDEDGRKMSKSLGNVVDP 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 566 LDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAAlASTGRDINWDMKRLEGYRNFCNKL 645
Cdd:COG0060 615 QEV-------------------------------------IDKYGADILRLWVAS-SDYWGDLRFSDEILKEVRDVYRRL 656
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 646 WNASRFVLMNTEGqdcgFNGGEMTLSLA-----DRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELT 720
Cdd:COG0060 657 RNTYRFLLANLDD----FDPAEDAVPYEdlpelDRWILSRLNELIKEVTEAYDNYDFHRAYRALHNFCVEDLSNWYLDIS 732
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 721 KPVM--NGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQrvkVLCGITADTIMLQPFPQYDASQVDEAALADTE 798
Cdd:COG0060 733 KDRLytEAADSLDRRAAQTTLYEVLETLVRLLAPILPFTAEEIWQ---NLPGEAEESVHLADWPEVDEELIDEELEAKWD 809
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 799 WLKQAIVAVR----NIRAEMNIapGKPLE-LLLRGCSADAERRVNENRGFLQTLARLESITVLPADDKGPVSVTKIIDGA 873
Cdd:COG0060 810 LVREVRSAVLkaleAARKEKLI--RQPLEaAVVLYADEELAAALESLGDLLAEELNVSEVELVDDAEDLGKDALKALDVE 887
|
....
gi 446338537 874 ELLI 877
Cdd:COG0060 888 GISV 891
|
|
| Anticodon_Ia_Val |
cd07962 |
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA ... |
630-764 |
5.28e-67 |
|
Anticodon-binding domain of valyl tRNA synthetases; This domain is found in valyl tRNA synthetases (ValRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. ValRS catalyzes the transfer of valine to the 3'-end of its tRNA.
Pssm-ID: 153416 [Multi-domain] Cd Length: 135 Bit Score: 220.12 E-value: 5.28e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 630 WDMKRLEGYRNFCNKLWNASRFVLMNTEGQDCGFNGGEmTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTW 709
Cdd:cd07962 1 FDEKRVEGGRNFCNKLWNAARFVLMNLEDDDEPEEDPE-SLSLADRWILSRLNKTVEEVTEALENYRFSEAATALYEFFW 79
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 446338537 710 NQFCDWYLELTKPVMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQR 764
Cdd:cd07962 80 NDFCDWYLELVKPRLYGEDEEEKKAARATLYYVLETILRLLHPFMPFITEELWQR 134
|
|
| Ile_Leu_Val_MetRS_core |
cd00668 |
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic ... |
35-630 |
2.48e-56 |
|
catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases; Catalytic core domain of isoleucyl, leucyl, valyl and methioninyl tRNA synthetases. These class I enzymes are all monomers. However, in some species, MetRS functions as a homodimer, as a result of an additional C-terminal domain. These enzymes aminoacylate the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. Enzymes in this subfamily share an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids. MetRS has a significantly shorter insertion, which lacks the editing function.
Pssm-ID: 185674 [Multi-domain] Cd Length: 312 Bit Score: 197.26 E-value: 2.48e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 35 FCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVVERKiAAEEGKTRHdygREAFIDKI 114
Cdd:cd00668 2 FYVTTPPPYANGSLHLGHALTHIIADFIARYKRMRGYEVPFLPGWDTHGLPIELKAERK-GGRKKKTIW---IEEFREDP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 115 WEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVnwdpklrtAISDlevenresk 194
Cdd:cd00668 78 KEFVEEMSGEHKEDFRRLGISYDWSDEYITTEPEYSKAVELIFSRLYEKGLIYRGTHPV--------RITE--------- 140
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 195 gsMWHIRYPLadgaktadgkdylvvattrpetllgdtgvavnpedprYKDLIGKYvilplvNRRIPivgdehadmekgtg 274
Cdd:cd00668 141 --QWFFDMPK-------------------------------------FKEKLLKA------LRRGK-------------- 161
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 275 cvkitpahdfndyevgkrhalpminiltfdgdiresaqvfdtkgnesdvysseipaefqklerfaarkavvaavdalgll 354
Cdd:cd00668 --------------------------------------------------------------------------------
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 355 eeikphdltvpygdrggvviepmltdqwyvradvlakpaveavengdiqFVPKQYENMYFSWMRDIQDWCISRQLWWGHR 434
Cdd:cd00668 162 -------------------------------------------------IVPEHVKNRMEAWLESLLDWAISRQRYWGTP 192
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 435 IPawydeagnvyvgrnedevrkennlgadvvlrqdEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFF 514
Cdd:cd00668 193 LP---------------------------------EDVFDVWFDSGIGPLGSLGYPEEKEWFKDSYPADWHLIGKDILRG 239
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 515 WIARMIMMTMHFikdeNGkpQVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVdgislpellekrtgnmmqpqladki 594
Cdd:cd00668 240 WANFWITMLVAL----FG--EIPPKNLLVHGFVLDEGGQKMSKSKGNVIDPSDVV------------------------- 288
|
570 580 590
....*....|....*....|....*....|....*.
gi 446338537 595 rkrtekqfpngiEPHGTDALRFTLAALASTGRDINW 630
Cdd:cd00668 289 ------------EKYGADALRYYLTSLAPYGDDIRL 312
|
|
| PLN02843 |
PLN02843 |
isoleucyl-tRNA synthetase |
11-892 |
1.49e-52 |
|
isoleucyl-tRNA synthetase
Pssm-ID: 215452 [Multi-domain] Cd Length: 974 Bit Score: 199.61 E-value: 1.49e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 11 EQPLYEHWEKQGYFKPNGDESQ-ESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMV 89
Cdd:PLN02843 9 EPEIQKLWEENQVYKRVSDRNNgESFTLHDGPPYANGDLHIGHALNKILKDFINRYQLLQGKKVHYVPGWDCHGLPIELK 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 90 VERKIAAEEgktrhdygREAFIDKIWEWKAESGG--TITRQM---RRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKED 164
Cdd:PLN02843 89 VLQSLDQEA--------RKELTPIKLRAKAAKFAkkTVDTQResfKRYGVWGDWENPYLTLDPEYEAAQIEVFGQMFLNG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 165 LIYRGKRLVNWDPKLRTAISDLEVENRE---SKgSMWHIrYPLADGAKTADGK-------DYLVVATTRPETLLGDTGVA 234
Cdd:PLN02843 161 YIYRGRKPVHWSPSSRTALAEAELEYPEghvSK-SIYVA-FPVVSPSETSPEEleeflpgLSLAIWTTTPWTMPANAAVA 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 235 VNP-------------EDPRYK------------------------DLIG--------KYVIL---------------PL 254
Cdd:PLN02843 239 VNDklqysvvevqsfsEDESTSggnkkkrpgnvlkeqqklflivatDLVPaleakwgvKLVVLktfpgsdlegcryihPL 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 255 VNRRIPIV-GDEHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILTFDGDIRESAQVFDTK-----GNESDVyssei 328
Cdd:PLN02843 319 YNRESPVViGGDYITTESGTGLVHTAPGHGQEDYITGLKYGLPLLSPVDDAGKFTEEAGQFSGLsvlgeGNAAVV----- 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 329 paefQKLErfaarkavvaaVDALGLLEEIKPHDLtvPYGDRggvVIEPML---TDQWYVRADVLAKPAVEAVENgdIQFV 405
Cdd:PLN02843 394 ----EALD-----------EAGSLLMEEAYGHKY--PYDWR---TKKPTIfraTEQWFASVEGFRQAALDAIDK--VKWI 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 406 PKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYD-EAGNVYVgrNEDEVRKENNL----GAD------VV--------- 465
Cdd:PLN02843 452 PAQGENRIRAMVSGRSDWCISRQRTWGVPIPVFYHvETKEPLM--NEETIAHVKSIvaqkGSDawwymdVEdllpekyrd 529
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 466 ----LRQDEDVLDTWFSSA------LWTFSTLGWP-----ENTDALRQFHPTSVMVSgfdiiffwIArmimmtmhfikdE 530
Cdd:PLN02843 530 kasdYEKGTDTMDVWFDSGsswagvLGSREGLSYPadlylEGSDQHRGWFQSSLLTS--------VA------------T 589
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 531 NGKpqVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDGislpellekrtgnmmqpqladkirKRTEKQFPNgiepHG 610
Cdd:PLN02843 590 KGK--APYKSVLTHGFVLDEKGFKMSKSLGNVVDPRLVIEG------------------------GKNQKQEPA----YG 639
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 611 TDALRFTLAALASTGrDINWDMKRL----EGYRnfcnKLWNASRFVLMNTEGQDCGFNGGEMTLSLADRWILAEFNQTIK 686
Cdd:PLN02843 640 ADVLRLWVASVDYTG-DVLIGPQILkqmsDIYR----KLRGTLRYLLGNLHDWKPDNAVPYEDLPSIDKYALFQLENVVN 714
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 687 AYREALDSFRFDIAAGILYEFTWNQFCDWYLELTKP--VMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQR 764
Cdd:PLN02843 715 EIEESYDNYQFFKIFQILQRFTIVDLSNFYLDVAKDrlYVGGTTSFTRRSCQTVLAAHLLSLLRAIAPILPHLAEDAWQN 794
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 765 VkvlcgitadtimlqPFPQY--DASQVDEAALA--DTEWL------KQAIVAVRNIRAEMNiapgKPLElllrgcSADAE 834
Cdd:PLN02843 795 L--------------PFQEDgsAAESVFEAGWPtpNEEWLsfpaedVDFWSLLLEVRDEVN----KVLE------SARNG 850
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*...
gi 446338537 835 RRVNenrgflqtlARLESITVLPADDKgpvsvtkiiDGAELLIPMAGLINKEDELARL 892
Cdd:PLN02843 851 KLIG---------ASLEAKVYLHASDA---------SLAARLAELCGASNGADELRRI 890
|
|
| LeuS |
COG0495 |
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA ... |
1-819 |
2.09e-50 |
|
Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Leucyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440261 [Multi-domain] Cd Length: 826 Bit Score: 191.80 E-value: 2.09e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 1 MEKTYNPQDIEQPLYEHWEKQGYFKPNGDESQESF--CIMIPPPnvTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVG 78
Cdd:COG0495 1 MQERYNPKEIEKKWQKYWEENGTFKADEDSSKPKYyvLDMFPYP--SGRLHMGHVRNYTIGDVVARYKRMQGYNVLHPMG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 79 TDHAGI-ATQMVVERKIAAEegktrhdygreafidkiwEWKAESGGTITRQMRRLGNSVDWERERFTMDEglsnavkE-- 155
Cdd:COG0495 79 WDAFGLpAENAAIKNGVHPA------------------EWTYENIANMRRQLKRLGLSYDWSREIATCDP-------Eyy 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 156 -----VFVRLYKEDLIYRGKRLVNWDPKLRTAI------------SDLEVENRESKgsMWHIR---YplAD--------- 206
Cdd:COG0495 134 kwtqwIFLQLYEKGLAYRKEAPVNWCPVDQTVLaneqvidgrcwrCGAPVEKKELP--QWFLKitdY--ADellddldkl 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 207 -------------------GA----KTADGKDYLVVATTRPETLLGDTGVAVNPEDP---------------------RY 242
Cdd:COG0495 210 dgwpekvktmqrnwigrseGAevdfPVEGSDEKITVFTTRPDTLFGATFMVLAPEHPlvkelatpeqnaavaafieeaKK 289
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 243 KDLI--------------GKYVILPLVNRRIPI-VgdehAD---MEKGTGCVKITPAHDFNDYEVGKRHALPMIniltfd 304
Cdd:COG0495 290 KSEIertsetkektgvftGLYAINPLTGEKIPIwI----ADyvlMDYGTGAVMAVPAHDQRDFEFAKKYGLPIK------ 359
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 305 gdiresaQVFDTKGNESdvysseipaefqklerfaarkavvaavdalglleeikPHDLTVPY-GDrgGVVIEP-----ML 378
Cdd:COG0495 360 -------QVIAPEDGDD-------------------------------------PDILEEAYtGD--GVLINSgefdgLD 393
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 379 TDQwyvradvlAKPAV--EAVENG----DIQFvpkqyenmyfswmRdIQDWCISRQLWWGHRIPAWYDEAGNVyVGRNED 452
Cdd:COG0495 394 SEE--------AKEAIieWLEEKGlgkrKVNY-------------R-LRDWLISRQRYWGEPIPIIHCEDCGV-VPVPED 450
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 453 E--VR----------KENNLGAD-----VVL-------RQDEDVLDTWF-SSalwtfstlgW-------PENTDAlrqfh 500
Cdd:COG0495 451 QlpVElpedvdfdptGGSPLARApewvnVTCpkcggpaRRETDTMDTFVdSS---------WyylrytdPHNDEA----- 516
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 501 ptsvMVSgFDIIFFWI------------------ARMIMMTMH---FIK-DEngkpqvPFHTVYMTGLIRD--------D 550
Cdd:COG0495 517 ----PFD-PEAANYWLpvdqyiggiehailhllyARFFTKVLRdlgLVSfDE------PFKRLLTQGMVLEvgkdgvviG 585
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 551 EGQKMSKSKGNVIDPLDMvdgislpellekrtgnmmqpqladkirkrtekqfpngIEPHGTDALRFTLAALASTGRDINW 630
Cdd:COG0495 586 GIEKMSKSKGNVVDPDEI-------------------------------------IEKYGADTLRLFEMFAGPPERDLEW 628
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 631 DMKRLEGYRNFCNKLWnasRFVLMNTEGQDCGFNggemTLSLADRWILAEFNQTIKAYREALDSFRFD--IAAgiLYEFT 708
Cdd:COG0495 629 SDSGVEGAYRFLNRVW---RLVVDEAEALKLDVA----DLSEADKELRRALHKTIKKVTEDIERLRFNtaIAA--LMELV 699
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 709 wNqfcdwylELTKpvmnggTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKvlcgiTADTIMLQPFPQYdasq 788
Cdd:COG0495 700 -N-------ALYK------AKDSGEADRAVLREALETLVLLLAPFAPHIAEELWERLG-----HEGSVADAPWPEA---- 756
|
970 980 990
....*....|....*....|....*....|...
gi 446338537 789 vDEAALADTEwlKQAIVAVrN--IRAEMNIAPG 819
Cdd:COG0495 757 -DEAALVEDE--VTIVVQV-NgkVRGKIEVPAD 785
|
|
| leuS |
PRK12300 |
leucyl-tRNA synthetase; Reviewed |
48-910 |
1.43e-49 |
|
leucyl-tRNA synthetase; Reviewed
Pssm-ID: 237049 [Multi-domain] Cd Length: 897 Bit Score: 189.69 E-value: 1.43e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 48 LHMGHAFQQTIMDTMIRYQRMQGKNTL----WQV-GTDHAGIAtqmvvERkIAAEEGKTRHDYGR---------EAFID- 112
Cdd:PRK12300 1 LHVGHGRTYTIGDVIARYKRMRGYNVLfpmaFHVtGTPILGIA-----ER-IARGDPETIELYKSlygipeeelEKFKDp 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 113 -KIWEWKAEsggTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLRTAISD---LEV 188
Cdd:PRK12300 75 eYIVEYFSE---EAKEDMKRIGYSIDWRREFTTTDPEYSKFIEWQFRKLKEKGLIVKGSHPVRYCPNDNNPVGDhdlLDG 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 189 ENRESkgsmwhIRYPLAdgaKTADGKD-YLVVATTRPETLLGDTGVAVNPE----------------------------- 238
Cdd:PRK12300 152 EEPEI------VEYTLI---KFEESEDlILPAATLRPETIFGVTNLWVNPDatyvkaevdgekwivskeaaeklsfqdrd 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 239 -----DPRYKDLIGKYVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDY----EVGKRHALPM----INILTFDG 305
Cdd:PRK12300 223 veiieEIKGSELIGKKVKNPVTGKEVPILPADFVDPDNGTGVVMSVPAHAPYDYvalrDLKKNKELLDviepIPLIEVEG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 306 -------DIRESAQVFDTKGNESDVYSSEI-PAEFQKlerfaarkavvaavdalGLLEEIkphdlTVPYGDR-------- 369
Cdd:PRK12300 303 ygefpakEVVEKLGIKSQEDPELEEATKEVyRAEFHK-----------------GVLKEN-----TGEYAGKpvrearek 360
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 370 --------------------------GGVVIEPMLTDQWYVR--ADVLAKPAVEAVENgdIQFVP----KQYENMYFsWM 417
Cdd:PRK12300 361 itkdliekgiadimyefsnrpvycrcGTECVVKVVKDQWFIDysDPEWKELAHKALDN--MEIIPeeyrKEFENTID-WL 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 418 RDiqdWCISRQLWWGHRIP-----------------AWYDEAgnvyvgrnedevRKENNLGADVVLRQDEdVLDTWF--- 477
Cdd:PRK12300 438 KD---RACARRRGLGTRLPwdeewiieslsdstiymAYYTIA------------HKIREYGIKPEQLTPE-FFDYVFlgk 501
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 478 SSALWTFSTLGWPENT-DALRQ----FHPTSVMVSGFDII-----FF------------WiARMIMMtmhfikdeNGkpq 535
Cdd:PRK12300 502 GDPEEVSKKTGIPKEIlEEMREeflyWYPVDWRHSGKDLIpnhltFFifnhvaifpeekW-PRGIVV--------NG--- 569
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 536 vpfhtvymTGLIrddEGQKMSKSKGNVIdpldmvdgislpeLLEKrtgnmmqpqladkirkrtekqfpnGIEPHGTDALR 615
Cdd:PRK12300 570 --------FVLL---EGKKMSKSKGNVI-------------PLRK------------------------AIEEYGADVVR 601
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 616 FTLAALASTGRDINWDMKRLEGYRNFCNKLWNasrFVLMNTEgqdcgfNGGEMTLSLADRWILAEFNQTIKAYREALDSF 695
Cdd:PRK12300 602 LYLTSSAELLQDADWREKEVESVRRQLERFYE---LAKELIE------IGGEEELRFIDKWLLSRLNRIIKETTEAMESF 672
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 696 RFDIAAG-ILYEFTwNQFcDWYLELTKpvmnggteaelRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKvlcgiTAD 774
Cdd:PRK12300 673 QTRDAVQeAFYELL-NDL-RWYLRRVG-----------EANNKVLREVLEIWIRLLAPFTPHLAEELWHKLG-----GEG 734
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 775 TIMLQPFPQYDASQVDEAALADTEWLKQAIVAVRNIraeMNIAPGKPlelllrgcsadaerrvnenrgflqtlarlESIT 854
Cdd:PRK12300 735 FVSLEKWPEPDESKIDEEAELAEEYVKRLIEDIREI---LKVAKIKP-----------------------------KKVY 782
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*.
gi 446338537 855 VLPADDKgPVSVTKIIDGAELLIPMAGLINKEDELARLAKEVAKIEGEISRIENKL 910
Cdd:PRK12300 783 IYVAPDW-KYEVLEIAAENGDVKEAIKELMKDEELRKHGKEVAKLAQKIVKEVLKL 837
|
|
| Anticodon_1 |
pfam08264 |
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA ... |
674-826 |
5.46e-45 |
|
Anticodon-binding domain of tRNA ligase; This domain is found mainly hydrophobic tRNA synthetases. The domain binds to the anticodon of the tRNA ligase.
Pssm-ID: 400523 [Multi-domain] Cd Length: 141 Bit Score: 158.72 E-value: 5.46e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 674 DRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQFCDWYLELTKPVMNggTEAELRGTRHTLVTVLEGLLRLAHPI 753
Cdd:pfam08264 1 DRWILSRLNKLIKEVTEAYENYRFNTAAQALYEFFWNDLSDWYLELIKDRLY--GEEPDSRAQTTLYEVLETLLRLLAPF 78
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446338537 754 IPFITETIWQRvkvlcgitaDTIMLQPFPQyDASQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPLELLL 826
Cdd:pfam08264 79 MPFITEELWQK---------ESIHLAPWPE-DAELEEAELEEAFELRQEIVQAIRKLRSELKIKKSLPLEVVI 141
|
|
| PLN02882 |
PLN02882 |
aminoacyl-tRNA ligase |
3-822 |
1.09e-35 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215477 [Multi-domain] Cd Length: 1159 Bit Score: 146.79 E-value: 1.09e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 3 KTYNPQDIEQPLYEHWEKQGYFKPN--GDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTD 80
Cdd:PLN02882 6 KDFSFPKQEEKILSLWSEIDAFKTQlkRTEGLPEYIFYDGPPFATGLPHYGHILAGTIKDIVTRYQSMTGHHVTRRFGWD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 81 HAGIAtqmvVERKIAAEEGKTRHDYGREAFIDKiweWKAESGGTITRQMR-------RLGNSVDWERERFTMDEGLSNAV 153
Cdd:PLN02882 86 CHGLP----VEYEIDKKLGIKRRDDVLKMGIDK---YNEECRSIVTRYSKewektvtRTGRWIDFENDYKTMDPKFMESV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 154 KEVFVRLYKEDLIYRGKRLVNWDPKLRTAISDLEV--ENRESKGSMWHIRYPLADGAKTADgkdyLVVATTRPETLLGDT 231
Cdd:PLN02882 159 WWVFKQLFEKGLVYKGFKVMPYSTACKTPLSNFEAglNYKDVSDPAVMVSFPIVGDPDNAS----FVAWTTTPWTLPSNL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 232 GVAVNPE------------------DPRYKDLIGK----------------YVIL------PLVNRRI-PI--------- 261
Cdd:PLN02882 235 ALCVNPNftyvkvrnkytgkvyivaESRLSALPTAkpkskkgskpenaaegYEVLakvpgsSLVGKKYePLfdyfsefsd 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 262 -----VGDEHADMEKGTGCVKITPAHDFNDYEV-------GKRHALPMinilTFDGDIRESAQVFDTKGNESDVYSSEIP 329
Cdd:PLN02882 315 tafrvVADDYVTDDSGTGVVHCAPAFGEDDYRVclangiiEKGGNLPV----PVDDDGCFTEKVTDFSGRYVKDADKDII 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 330 AEFQKLERFaarkavvaavdalglleeIKPHDLT--VPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEavENGDIQFVPK 407
Cdd:PLN02882 391 AAIKAKGRL------------------VKSGSIThsYPFCWRSDTPLIYRAVPSWFVKVEEIKDRLLE--NNKQTYWVPD 450
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 408 QY-ENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGN-VYVGRNEDEVRKENNLGAD--------------------VV 465
Cdd:PLN02882 451 YVkEKRFHNWLENARDWAVSRSRFWGTPLPIWISDDGEeVVVIGSIAELEKLSGVKVTdlhrhfidhitipssrgpefGV 530
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 466 LRQDEDVLDTWFSSALWTFSTLGWP-ENTDALRQFHPTSVMVSGFDIIFFWI-ARMIMMTMHFikdenGKPqvPFHTVYM 543
Cdd:PLN02882 531 LRRVDDVFDCWFESGSMPYAYIHYPfENKELFEKNFPADFVAEGLDQTRGWFyTLMVLSTALF-----DKP--AFKNLIC 603
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 544 TGLIRDDEGQKMSKSKGNVIDPLDMVDgislpellekrtgnmmqpqladkirkrtekqfpngiePHGTDALRFTLaalas 623
Cdd:PLN02882 604 NGLVLAEDGKKMSKSLKNYPDPNEVID-------------------------------------KYGADALRLYL----- 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 624 tgrdINWDMKRLEGYRnFCNK------------LWNASRFVLMNT-----EGQD--CGFNGGEMTLS--LADRWILAEFN 682
Cdd:PLN02882 642 ----INSPVVRAEPLR-FKEEgvfgvvkdvflpWYNAYRFLVQNAkrlevEGGApfVPLDLAKLQNSanVLDRWINSATQ 716
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 683 QTIKAYREALDSFRFDIAAGILYEFTwNQFCDWYLELTKPVMNGGT-EAELRGTRHTLVTVLEGLLRLAHPIIPFITETI 761
Cdd:PLN02882 717 SLVKFVREEMGAYRLYTVVPYLVKFI-DNLTNIYVRFNRKRLKGRTgEEDCRTALSTLYNVLLTSCKVMAPFTPFFTEVL 795
|
890 900 910 920 930 940
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446338537 762 WQRVKVLCGITADTIMLQPFPQYDASQVDEAALADTEWLKQAIVAVRNIRAEMNIAPGKPL 822
Cdd:PLN02882 796 YQNLRKVLPGSEESIHYCSFPQVDEGELDERIEQSVSRMQTVIELARNIRERHNKPLKTPL 856
|
|
| PLN02563 |
PLN02563 |
aminoacyl-tRNA ligase |
9-787 |
7.85e-30 |
|
aminoacyl-tRNA ligase
Pssm-ID: 178177 [Multi-domain] Cd Length: 963 Bit Score: 127.63 E-value: 7.85e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 9 DIEQPLYEHWEKQGYFK-PNG-DESQESFCI--MIPPPNVTGsLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGI 84
Cdd:PLN02563 84 EIEPKWQRYWEENRTFRtPDDvDTSKPKFYVldMFPYPSGAG-LHVGHPEGYTATDILARYKRMQGYNVLHPMGWDAFGL 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 85 -ATQMVVERKIAAEEGKTRHdygreafIDKIwewkaesggtiTRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKE 163
Cdd:PLN02563 163 pAEQYAIETGTHPKITTLKN-------IARF-----------RSQLKSLGFSYDWDREISTTEPEYYKWTQWIFLQLLKR 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 164 DLIYRGKRLVNWDPKLRTAISDLEVENRES-KGSMWHIRYPL----------AD-------------GAKTA-------- 211
Cdd:PLN02563 225 GLAYQAEVPVNWCPALGTVLANEEVVDGLSeRGGHPVIRKPMrqwmlkitayADrlledlddldwpeSIKEMqrnwigrs 304
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 212 ------------DGKD---YLVVATTRPETLLGDTGVAVNPEDP---------------RYKDL---------------- 245
Cdd:PLN02563 305 egaeldfsvldgEGKErdeKITVYTTRPDTLFGATYLVVAPEHPllsslttaeqkeaveEYVDAasrksdlertelqkek 384
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 246 ----IGKYVILPLVNRRIPI-VGDeHADMEKGTGCVKITPAHDFNDYEVGKRHALPMINILT-FDGDIRESAQVFDTKGn 319
Cdd:PLN02563 385 tgvfTGSYAINPATGEAIPIwVAD-YVLGSYGTGAIMAVPAHDTRDFEFAQKFDLPIKWVVKpADGNEDDAEKAYTGEG- 462
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 320 eSDVYSSEIPAEFQklerfaarkavvaavdalGLLEEikphdltvpygDRGGVVIEpmltdqWyvradvlakpaVEAVEN 399
Cdd:PLN02563 463 -VIVNSSSSGLDIN------------------GLSSK-----------EAAKKVIE------W-----------LEETGN 495
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 400 GDIQFVPKqyenmyfswmrdIQDWCISRQLWWGHRIPAWYDEAGNVYVGRNEDEV--------------RKENNLGADVV 465
Cdd:PLN02563 496 GKKKVNYK------------LRDWLFARQRYWGEPIPVVFLEDSGEPVPVPESDLpltlpelddftptgTGEPPLAKAVS 563
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 466 LRQDEDVLD-TWFS----------SALWTFSTLGWPENTDAL------RQFHPTSVMVSGFD--IIFFWIARMIMMTMHF 526
Cdd:PLN02563 564 WVNTVDPSSgKPARretntmpqwaGSCWYYLRFMDPKNSNALvdkekeKYWMPVDLYVGGAEhaVLHLLYARFWHKVLYD 643
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 527 IKDENGKPqvPFHTVYMTGLI---------RDDEGQKMSkskGNVIDPLDMVDGISLPELLEKRTGNMMQPQLADKIR-- 595
Cdd:PLN02563 644 IGVVSTKE--PFQCLVNQGMIlgeveytafKDSDGEYVS---ADTADRLGELQQEKIPEEKVIKSGDSFVLKDDPSIRli 718
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 596 ---KRTEKQFPNGIEP------HGTDALRFTLAALASTgRDIN-WDMKRLEGYRNFCNKLWNasrfVLMNTEGQDCGFNG 665
Cdd:PLN02563 719 araHKMSKSRGNVVNPddvvseYGADSLRLYEMFMGPL-RDSKtWSTSGVEGVHRFLGRTWR----LVVGAPLPDGSFRD 793
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 666 GEMTLSL-ADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTwNQFCDWYlelTKPvmnggteaelrgtrhtlVTVLE 744
Cdd:PLN02563 794 GTVVTDEePSLEQLRLLHKCIAKVTEEIESTRFNTAISAMMEFT-NAAYKWD---KVP-----------------REAIE 852
|
890 900 910 920
....*....|....*....|....*....|....*....|...
gi 446338537 745 GLLRLAHPIIPFITETIWQRvkvlCGiTADTIMLQPFPQYDAS 787
Cdd:PLN02563 853 PFVLLLSPYAPHLAEELWFR----LG-HSNSLAYEPWPEANPS 890
|
|
| IleRS_core |
cd00818 |
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases ... |
379-570 |
9.84e-30 |
|
catalytic core domain of isoleucyl-tRNA synthetases; Isoleucine amino-acyl tRNA synthetases (IleRS) catalytic core domain . This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. IleRS has an insertion in the core domain, which is subject to both deletions and rearrangements. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173909 [Multi-domain] Cd Length: 338 Bit Score: 121.19 E-value: 9.84e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 379 TDQWYVRADVLAKPAVEAVENgdIQFVPKQYENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNvyvgrnedevrken 458
Cdd:cd00818 150 TPQWFIRVTKIKDRLLEANDK--VNWIPEWVKNRFGNWLENRRDWCISRQRYWGTPIPVWYCEDCG-------------- 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 459 nlgaDVVLRQDEDVLDTWFSSALWTFSTLGWPENTDALRQFHPTSVMVSGFDIIFFWI-ARMIMMTMHFikdenGKPqvP 537
Cdd:cd00818 214 ----EVLVRRVPDVLDVWFDSGSMPYAQLHYPFENEDFEELFPADFILEGSDQTRGWFySLLLLSTALF-----GKA--P 282
|
170 180 190
....*....|....*....|....*....|...
gi 446338537 538 FHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVD 570
Cdd:cd00818 283 YKNVIVHGFVLDEDGRKMSKSLGNYVDPQEVVD 315
|
|
| Anticodon_Ia_Ile_ABEc |
cd07961 |
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA ... |
639-808 |
6.49e-27 |
|
Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial, archaeal, and eukaryotic cytoplasmic members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153415 [Multi-domain] Cd Length: 183 Bit Score: 108.41 E-value: 6.49e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 639 RNFCNKLWNASRFVLMNTEgqDCGFNGGEMTLSLA-----DRWILAEFNQTIKAYREALDSFRFDIAAGILYEFtWNQFC 713
Cdd:cd07961 11 RKVLLPLWNAYRFFVTYAN--LDGFDPGKDDDAVAslnvlDRWILSRLNSLIKEVTEEMEAYDLYTAVRALLEF-IDELT 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 714 DWYLELTKPVM-NGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKVLCGITADTIMLQPFPQYDASQVDEA 792
Cdd:cd07961 88 NWYIRRNRKRFwGEEGDDDKLAAYATLYEVLLTLSRLMAPFTPFITEEIYQNLRRELGDAPESVHLLDWPEVDESLIDEE 167
|
170
....*....|....*.
gi 446338537 793 ALADTEWLKQAIVAVR 808
Cdd:cd07961 168 LEEAMELVREIVELGR 183
|
|
| PTZ00427 |
PTZ00427 |
isoleucine-tRNA ligase, putative; Provisional |
6-825 |
2.03e-26 |
|
isoleucine-tRNA ligase, putative; Provisional
Pssm-ID: 173617 [Multi-domain] Cd Length: 1205 Bit Score: 116.99 E-value: 2.03e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 6 NPQDIE--QPLYEHWEKQGYFKPNGD--ESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDH 81
Cdd:PTZ00427 71 NPNIVEeeEKVLKYWKSIDAFNTSNKlaKNKKAYIFYDGPPFATGLPHYGHLLAGIIKDCVTRYFYQCGFSVERKFGWDC 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 82 AGIATQMVVERKIAAEEGKTRHDYGREAFIDKIWEWKAESGGTITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLY 161
Cdd:PTZ00427 151 HGLPIEYEIEKENNINKKEDILKMGIDVYNEKCRGIVLKYSNEWVKTVERIGRWIDFKNDYKTMDKTFMESVWWVFSELY 230
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 162 KEDLIYRGKRLVNWDPKLRTAISDLEV--------------------------------ENRESKGSMWHIRY------P 203
Cdd:PTZ00427 231 KNNYVYKSFKVMPYSCKCNTPISNFELnlnykdtpdpsiiisfvlcsdfpkveeecnieEDKQLLGEKYSVLYnnkrenS 310
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 204 LADGAKTADGKDY-----LVVATTRPETLLGDTGVAVNP----------------------------------EDP---- 240
Cdd:PTZ00427 311 NNGNNNSTNNVCYaqhseILAWTTTPWTLPSNLALCVNEhftylrihhvksnrvvivgecrlewimkelkwnvEDLkivn 390
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 241 ----------RYKDLIGK-YVILPLVNRRIPIVGDEHADMEKGTGCVKITPAHDFNDYEVGKRHalpminiltfdGDIRE 309
Cdd:PTZ00427 391 rfkgkelkglRYKPLFTNfYEKYNFKERAYKILADDFVTDDAGTGIVHCAPTYGEDDFRVCKKN-----------GVIDP 459
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 310 SAQVFDTKGNESDVYSSEIpaefQKLERFAARKAVVAAVDALGLLEEIKPHDLTV---PYGDRGGVVIEPMLTDQWYVRa 386
Cdd:PTZ00427 460 EKNIFIDPLDANGYFTNEV----EEVQNLYIKEADNVIKKKLKNENRLLSNNTIVhsyPFCWRSDTPLIYRAIPAWFIR- 534
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 387 dvLAKPAVEAVENGDIQF-VPKQY-ENMYFSWMRDIQDWCISRQLWWGHRIPAWYDEAGNVYVGRNE------------- 451
Cdd:PTZ00427 535 --VSNSTNELVKNNETTYwIPAHIkEKKFHNWIKDAKDWCISRNRYWGTPIPIWADEKMETVICVESikhleelsgvkni 612
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 452 --------DEVRKENNLGADV-VLRQDEDVLDTWFSSALWTFSTLGWPENTDAlRQFH---PTSVMVSGFDIIFFWIARM 519
Cdd:PTZ00427 613 ndlhrhfiDHIEIKNPKGKTYpKLKRIPEVFDCWFESGSMPYAKVHYPFSTEK-EDFHkifPADFIAEGLDQTRGWFYTL 691
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 520 IMM-TMHFIKdengkpqVPFHTVYMTGLIRDDEGQKMSKSKGNVIDPLDMVDgislpellekrtgnmmqpqladkirkrt 598
Cdd:PTZ00427 692 LVIsTLLFDK-------APFKNLICNGLVLASDGKKMSKRLKNYPDPLYILD---------------------------- 736
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 599 ekqfpngiePHGTDALRFTLA-ALASTGRDINWDMKRL-EGYRNFCNKLWNASRFVLMNTEGQDCgFNGGEMTL------ 670
Cdd:PTZ00427 737 ---------KYGADSLRLYLInSVAVRAENLKFQEKGVnEVVKSFILPFYHSFRFFSQEVTRYEC-LNKKQFLFntdyiy 806
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 671 ---SLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNqFCDWYLELTKPVMNG--GTEAELRgTRHTLVTVLEG 745
Cdd:PTZ00427 807 kndNIMDQWIFSSVQSLTKSVHTEMKAYKLYNVLPKLLQFIEN-LTNWYIRLNRDRMRGslGEENCLQ-SLCTTYRTLHL 884
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 746 LLRLAHPIIPFITETIWQRVKVLC---------------------GITADTIMLQPFPQYDAS-QVDEAALADTEWLKQA 803
Cdd:PTZ00427 885 FTVLMAPFTPFITEYIYQQLRRVKstnehnennetgntkegdlnrGVIHKSVHFIMLPQVDEKyIIDYEIIELIEKMKDV 964
|
970 980
....*....|....*....|..
gi 446338537 804 IVAVRNIRAEMNIAPGKPLELL 825
Cdd:PTZ00427 965 ILLGRVLRERRKVASKKPLKSI 986
|
|
| PRK11893 |
PRK11893 |
methionyl-tRNA synthetase; Reviewed |
421-763 |
2.70e-20 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237012 [Multi-domain] Cd Length: 511 Bit Score: 95.72 E-value: 2.70e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 421 QDWCISRQ-LWWGHRIPAwyDEAGNVYVgrnedevrkennlgadvvlrqdedvldtWFSsALWTF-STLGWPENTDAL-- 496
Cdd:PRK11893 199 KDLSISRTnFDWGIPVPG--DPKHVIYV----------------------------WFD-ALTNYlTALGYPDDEELLae 247
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 497 --RQFHPTSVMVSGFDIIFF----WIArmimMTMHfikdeNGKPQvpFHTVYMTGLIRDDeGQKMSKSKGNVIDPLDMVD 570
Cdd:PRK11893 248 lfNKYWPADVHLIGKDILRFhavyWPA----FLMA-----AGLPL--PKRVFAHGFLTLD-GEKMSKSLGNVIDPFDLVD 315
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 571 gislpellekrtgnmmqpqladkirkrtekQFpngiephGTDALRFTLAALASTGRDINWDMKRLEGYRN--FCNKLWN- 647
Cdd:PRK11893 316 ------------------------------EY-------GVDAVRYFLLREIPFGQDGDFSREAFINRINadLANDLGNl 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 648 ASRFVLMNteGQDCGFNGGEM-TLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTwnQFCDWYLELTKPVMNG 726
Cdd:PRK11893 359 AQRTLSMI--AKNFDGKVPEPgALTEADEALLEAAAALLERVRAAMDNLAFDKALEAILALV--RAANKYIDEQAPWSLA 434
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 446338537 727 GTEAELRGTrhTLVTVLEGLLRLA---HPIIPFITETIWQ 763
Cdd:PRK11893 435 KTDPERLAT--VLYTLLEVLRGIAvllQPVMPELAAKILD 472
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
37-180 |
1.26e-19 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 90.77 E-value: 1.26e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 37 IMIPPPNvtGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDhagiATQMVVERkiAAEEGKTRHDYGREAFIDKiwe 116
Cdd:cd00812 6 VMFPYPS--GALHVGHVRTYTIGDIIARYKRMQGYNVLFPMGFD----AFGLPAEN--AAIKIGRDPEDWTEYNIKK--- 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446338537 117 wkaesggtITRQMRRLGNSVDWERERFTMDEGLSNAVKEVFVRLYKEDLIYRGKRLVNWDPKLR 180
Cdd:cd00812 75 --------MKEQLKRMGFSYDWRREFTTCDPEYYKFTQWLFLKLYEKGLAYKKEAPVNWCKLLD 130
|
|
| MetG |
COG0143 |
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA ... |
398-763 |
5.39e-19 |
|
Methionyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Methionyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439913 [Multi-domain] Cd Length: 544 Bit Score: 91.71 E-value: 5.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 398 ENGDIQfvpKQYENMYFSWMRD-IQDWCISRQLWWGHRIPawyDEAGNV-YVgrnedevrkennlgadvvlrqdedvldt 475
Cdd:COG0143 203 ENPDIQ---PEVRNEVLSWLKEgLQDLSISRDFDWGIPVP---GDPGKVfYV---------------------------- 248
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 476 WFSsALWTF--STLGWPENTDALRQFHPtsvmvsgfdiifFWIA---RMImmtmHFIkdenGKPQVPFHTVY---M---T 544
Cdd:COG0143 249 WFD-ALIGYisATKGYADDRGLPEDFEK------------YWPApdtELV----HFI----GKDIIRFHAIIwpaMlmaA 307
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 545 GLIRDD----------EGQKMSKSKGNVIDPLDMVDgislpellekrtgnmmqpqladkirkrtekQFpngiephGTDAL 614
Cdd:COG0143 308 GLPLPKkvfahgfltvEGEKMSKSRGNVIDPDDLLD------------------------------RY-------GPDAL 350
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 615 RFTLAALASTGRDINWDMKRLEGyRN---FCNKLWN-ASRFVLM---NTEGQ--DCGfnggemTLSLADRWILAEFNQTI 685
Cdd:COG0143 351 RYYLLREVPFGQDGDFSWEDFVA-RVnsdLANDLGNlASRTLSMihkYFDGKvpEPG------ELTEADEELLAEAEAAL 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 686 KAYREALDSFRFDIAAGILYEFTwnQFCDWYLELTKP--VMNGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQ 763
Cdd:COG0143 424 EEVAEAMEAFEFRKALEEIMALA--RAANKYIDETAPwkLAKDEDPERLATVLYTLLEALRILAILLKPFLPETAEKILE 501
|
|
| Val_tRNA-synt_C |
pfam10458 |
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA ... |
886-944 |
1.86e-17 |
|
Valyl tRNA synthetase tRNA binding arm; This domain is found at the C-terminus of Valyl tRNA synthetases.
Pssm-ID: 431296 [Multi-domain] Cd Length: 66 Bit Score: 77.31 E-value: 1.86e-17
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*....
gi 446338537 886 EDELARLAKEVAKIEGEISRIENKLANEGFVARAPEAVIAKEREKLEGYAEAKAKLIEQ 944
Cdd:pfam10458 3 EKERARLEKELAKLQKEIERVQGKLANPGFVAKAPAEVVEEEKAKLAELEEQAEKLRER 61
|
|
| Anticodon_Ia_like |
cd07375 |
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This ... |
633-753 |
4.78e-14 |
|
Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; This domain is found in a variety of class Ia aminoacyl tRNA synthetases, C-terminal to the catalytic core domain. It recognizes and specifically binds to the anticodon of the tRNA. Aminoacyl tRNA synthetases catalyze the transfer of cognate amino acids to the 3'-end of their tRNAs by specifically recognizing cognate from non-cognate amino acids. Members include valyl-, leucyl-, isoleucyl-, cysteinyl-, arginyl-, and methionyl-tRNA synthethases. This superfamily also includes a domain from MshC, an enzyme in the mycothiol biosynthetic pathway.
Pssm-ID: 153408 [Multi-domain] Cd Length: 117 Bit Score: 69.46 E-value: 4.78e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 633 KRLEGYRNFCNKLWNASRFVLMNTEGQDCGFNGgeMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTWNQf 712
Cdd:cd07375 2 ERLKQARAFLNRLYRLLSFFRKALGGTQPKWDN--ELLEEADRELLARLQEFIKRTTNALEALDPTTAVQELFKFTNEL- 78
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446338537 713 cDWYLELTKPVmnGGTEAELRGTRHTLVTVLEGLLRLAHPI 753
Cdd:cd07375 79 -NWYLDELKPA--LQTEELREAVLAVLRAALVVLTKLLAPF 116
|
|
| metG |
TIGR00398 |
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ... |
37-764 |
6.05e-14 |
|
methionine--tRNA ligase; The methionyl-tRNA synthetase (metG) is a class I amino acyl-tRNA ligase. This model appears to recognize the methionyl-tRNA synthetase of every species, including eukaryotic cytosolic and mitochondrial forms. The UPGMA difference tree calculated after search and alignment according to this model shows an unusual deep split between two families of MetG. One family contains forms from the Archaea, yeast cytosol, spirochetes, and E. coli, among others. The other family includes forms from yeast mitochondrion, Synechocystis sp., Bacillus subtilis, the Mycoplasmas, Aquifex aeolicus, and Helicobacter pylori. The E. coli enzyme is homodimeric, although monomeric forms can be prepared that are fully active. Activity of this enzyme in bacteria includes aminoacylation of fMet-tRNA with Met; subsequent formylation of the Met to fMet is catalyzed by a separate enzyme. Note that the protein from Aquifex aeolicus is split into an alpha (large) and beta (small) subunit; this model does not include the C-terminal region corresponding to the beta chain. [Protein synthesis, tRNA aminoacylation]
Pssm-ID: 273058 [Multi-domain] Cd Length: 530 Bit Score: 75.49 E-value: 6.05e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 37 IMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATqmvvERKiAAEEGKTrhdygREAFIDKIWE 116
Cdd:TIGR00398 3 ITTALPYANGKPHLGHAYTTILADVYARYKRLRGYEVLFVCGTDEHGTKI----ELK-AEQEGLT-----PKELVDKYHE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 117 wkaesggTITRQMRRLGNSVDwereRF--TMDEGLSNAVKEVFVRLYKEDLIYrgkrlvnwdpklrtaisdleveNRESK 194
Cdd:TIGR00398 73 -------EFKDDWKWLNISFD----RFirTTDEEHKEIVQKIFQKLKENGYIY----------------------EKEIK 119
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 195 GsmwhirypladgaktadgkdylvvattrpetllgdtgvAVNPEDPRYKdligkyvilplvnrripivgdehADMEKGTG 274
Cdd:TIGR00398 120 Q--------------------------------------LYCPECEMFL-----------------------PDRYVEGT 138
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 275 CvkitpahdfndyevgkrhalPMINILTFDGDIREsaqvfdtkgnesdvysseipaefqklerfaarkavvaavdALGLL 354
Cdd:TIGR00398 139 C--------------------PKCGSEDARGDHCE----------------------------------------VCGRH 158
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 355 EEikPHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDI-QFVPKQYENMYFSWMRD-IQDWCISRQL-WW 431
Cdd:TIGR00398 159 LE--PTELINPRCKICGAKPELRDSEHYFFRLSAFEKELEEWIRKNPEsGSPASNVKNKAQNWLKGgLKDLAITRDLvYW 236
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 432 GHRIPawYDEAGNVYVgrnedevrkennlgadvvlrqdedvldtWFSSALWTFSTLGWPENTDAlrqfhptsvmvsgfDI 511
Cdd:TIGR00398 237 GIPVP--NDPNKVVYV----------------------------WFDALIGYISSLGILSGDTE--------------DW 272
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 512 IFFWIARMIMMTMHFIkdenGKPQVPFHTVYMTGLIR----------------DDEGQKMSKSKGNVIDPLDMVDGIslp 575
Cdd:TIGR00398 273 KKWWNNDEDAELIHFI----GKDIVRFHTIYWPAMLMglglplptqvfshgylTVEGGKMSKSLGNVVDPSDLLARF--- 345
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 576 ellekrtgnmmqpqladkirkrtekqfpngiephGTDALRFTLAALASTGRDINWDMKRLEGYRN--FCNKLWN-ASRFV 652
Cdd:TIGR00398 346 ----------------------------------GADILRYYLLKERPLGKDGDFSWEDFVERVNadLANKLGNlLNRTL 391
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 653 LMntegQDCGFNG---GEMTLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYE--FTWNQFCD----WYLELtkpv 723
Cdd:TIGR00398 392 GF----IKKYFNGvlpSEDITDEEDKKLLKLINEALEQIDEAIESFEFRKALREIMKlaDRGNKYIDenkpWELFK---- 463
|
730 740 750 760
....*....|....*....|....*....|....*....|.
gi 446338537 724 mNGGTEAELRGTRHTLVTVLEGLLRlahPIIPFITETIWQR 764
Cdd:TIGR00398 464 -QSPRLKELLAVCSMLIRVLSILLY---PIMPKLSEKILKF 500
|
|
| Anticodon_Ia_Ile_BEm |
cd07960 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; ... |
632-815 |
5.82e-13 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; This domain is found in isoleucyl tRNA synthetases (IleRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon. This family includes bacterial and eukaryotic mitochondrial members. IleRS catalyzes the transfer of isoleucine to the 3'-end of its tRNA.
Pssm-ID: 153414 [Multi-domain] Cd Length: 180 Bit Score: 67.94 E-value: 5.82e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 632 MKRL-EGYRnfcnKLWNASRFVLMNTEGqdcgFNGGEMT-----LSLADRWILAEFNQTIKAYREALDSFRFDIAAGILY 705
Cdd:cd07960 6 LKQVaEAYR----KIRNTFRFLLGNLND----FDPAKDAvpyeeLLELDRYALHRLNELIKEVREAYENYEFHKVYQALN 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 706 EFTWNQFCDWYLELTKPVM--NGGTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQRVKvlCGITADTIMLQPFPQ 783
Cdd:cd07960 78 NFCTVDLSAFYLDIIKDRLycDAKDSLERRSAQTVLYHILDALLKLLAPILPFTAEEVWEHLP--GEKKEESVFLEDWPE 155
|
170 180 190
....*....|....*....|....*....|..
gi 446338537 784 YDASQVDEAALADTEWLkqaivavRNIRAEMN 815
Cdd:cd07960 156 LPEEWKDEELEEKWEKL-------LALRDEVN 180
|
|
| Anticodon_Ia_Leu_AEc |
cd07959 |
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This ... |
662-765 |
4.43e-12 |
|
Anticodon-binding domain of archaeal and eukaryotic cytoplasmic leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes archaeal and eukaryotic cytoplasmic members. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153413 [Multi-domain] Cd Length: 117 Bit Score: 63.76 E-value: 4.43e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 662 GFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRF-DIAAGILYEFTwnQFCDWYLELTKPVMNGGteaelrgtrhTLV 740
Cdd:cd07959 25 ETEGELEELTFIDRWLLSRLNRLIKETTEAYENMQFrEALKEGLYELQ--NDLDWYRERGGAGMNKD----------LLR 92
|
90 100
....*....|....*....|....*
gi 446338537 741 TVLEGLLRLAHPIIPFITETIWQRV 765
Cdd:cd07959 93 RFIEVWTRLLAPFAPHLAEEIWHEL 117
|
|
| Anticodon_Ia_Leu_BEm |
cd07958 |
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; ... |
630-764 |
2.42e-10 |
|
Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; This domain is found in leucyl tRNA synthetases (LeuRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain. In contrast to other class Ia enzymes, the anticodon is not used as an identity element in LeuRS (with exceptions such as Saccharomyces cerevisiae and some other eukaryotes). No anticodon-binding site can be defined for this family, which includes bacterial and eukaryotic mitochondrial members, as well as LeuRS from the archaeal Halobacteria. LeuRS catalyzes the transfer of leucine to the 3'-end of its tRNA.
Pssm-ID: 153412 [Multi-domain] Cd Length: 117 Bit Score: 58.77 E-value: 2.42e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 630 WDMKRLEGYRNFCNKLWnasRFVLMNTEGQDcgFNGGEMTLSLADRWILAEFNQTIKAYREALDSFRFD--IAAgiLYEF 707
Cdd:cd07958 1 WSDSGVEGAYRFLNRVW---RLVTELAEALA--APAAAAELSEEDKELRRKLHKTIKKVTEDIERLRFNtaIAA--LMEL 73
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446338537 708 TwNqfcdwylELTKpvmnggTEAELRGTRHTLVTVLEGLLRLAHPIIPFITETIWQR 764
Cdd:cd07958 74 V-N-------ALYK------YKKKDAQHAAVLREALETLVLLLAPFAPHIAEELWEE 116
|
|
| tRNA-synt_1g |
pfam09334 |
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases. |
359-631 |
3.23e-10 |
|
tRNA synthetases class I (M); This family includes methionyl tRNA synthetases.
Pssm-ID: 401322 [Multi-domain] Cd Length: 387 Bit Score: 63.08 E-value: 3.23e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 359 PHDLTVPYGDRGGVVIEPMLTDQWYVRADVLAKPAVEAVENGDIQFvPKQYENMYFSWMRD-IQDWCISRQLWWGHRIPA 437
Cdd:pfam09334 161 PTELINPKCVICGTTPEVKETEHYFFDLSKFQDKLREWIEENNPEW-PENVKNMVLEWLKEgLKDRAISRDLDWGIPVPG 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 438 wyDEAGNVYVgrnedevrkennlgadvvlrqdedvldtWFssalwtfstlgwpentDALRQFHPTSVMVSGFDIIF--FW 515
Cdd:pfam09334 240 --AEGKVFYV----------------------------WL----------------DAPIGYISATKELSGNEEKWkeWW 273
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 516 IARMIMMTMHFIkdenGKPQVPFHTVYMTGLIRDD----------------EGQKMSKSKGNVIDPLDMVDgislpelle 579
Cdd:pfam09334 274 PNDPDTELVHFI----GKDIIYFHTIFWPAMLLGAgyrlpttvfahgyltyEGGKMSKSRGNVVWPSEALD--------- 340
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446338537 580 krtgnmmqpqladkirkrtekQFPngiephgTDALRFTLAALASTGRDIN--WD 631
Cdd:pfam09334 341 ---------------------RFP-------PDALRYYLARNRPETKDTDfsWE 366
|
|
| tRNA-synt_1_2 |
pfam13603 |
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ... |
219-318 |
2.99e-09 |
|
Leucyl-tRNA synthetase, Domain 2; This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
Pssm-ID: 433342 [Multi-domain] Cd Length: 185 Bit Score: 57.56 E-value: 2.99e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 219 VATTRPETLLGDTGVAVNPE----------DPRYKDLI-----------------------GKYVILPLVNRRIPI-Vgd 264
Cdd:pfam13603 25 VFTTRPDTLMGVTFVALAPEhplveklaekNPEVAAFIeeckntseiertsetkekegvftGLYAIHPITGEKIPIwI-- 102
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 265 ehAD---MEKGTGCVKITPAHDFNDYEVGKRHALPMINILT---FDGDIRESAQVFDTKG 318
Cdd:pfam13603 103 --ANfvlMEYGTGAVMAVPAHDQRDFEFAKKYNLPIKPVIQpedGDLDLDIMTEAYTEEG 160
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
485-760 |
1.22e-08 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 58.66 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 485 STLGWPENTDALrqfhptsvmvsgFDIifFWIArmimmTMHFIkdenGKPQVPFHTVY------MTGL------------ 546
Cdd:PRK12267 237 TALGYGSDDDEL------------FKK--FWPA-----DVHLV----GKDILRFHAIYwpimlmALGLplpkkvfahgww 293
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 547 IRDDegQKMSKSKGNVIDPLDMVDgislpellekrtgnmmqpqladkirkrtekqfpngiePHGTDALRFTLAALASTGR 626
Cdd:PRK12267 294 LMKD--GKMSKSKGNVVDPEELVD-------------------------------------RYGLDALRYYLLREVPFGS 334
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 627 D-----------INWDMkrlegyrnfCNKLWN-ASRFVLMNTEgqdcgFNGGEMTLSLA----DRWILAEFNQTIKAYRE 690
Cdd:PRK12267 335 DgdfspealverINSDL---------ANDLGNlLNRTVAMINK-----YFDGEIPAPGNvtefDEELIALAEETLKNYEE 400
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446338537 691 ALDSFRFDIAAGILYEF--TWNQfcdwYLELTKP-VM--NGGTEAELrGTrhTLVTVLEGLLRLAHPIIPFITET 760
Cdd:PRK12267 401 LMEELQFSRALEEVWKLisRANK----YIDETAPwVLakDEGKKERL-AT--VMYHLAESLRKVAVLLSPFMPET 468
|
|
| LeuRS_core |
cd00812 |
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic ... |
377-570 |
2.32e-08 |
|
catalytic core domain of leucyl-tRNA synthetases; Leucyl tRNA synthetase (LeuRS) catalytic core domain. This class I enzyme is a monomer which aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. In Aquifex aeolicus, the gene encoding LeuRS is split in two, just before the KMSKS motif. Consequently, LeuRS is a heterodimer, which likely superimposes with the LeuRS monomer found in most other organisms. LeuRS has an insertion in the core domain, which is subject to both deletions and rearrangements and thus differs between prokaryotic LeuRS and archaeal/eukaryotic LeuRS. This editing region hydrolyzes mischarged cognate tRNAs and thus prevents the incorporation of chemically similar amino acids.
Pssm-ID: 173906 [Multi-domain] Cd Length: 314 Bit Score: 56.87 E-value: 2.32e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 377 MLTDQWYVRADV--LAKPAVEAVENgdIQFVPKQYENMyfswMRDIQDwcISRQLWWGHRIPaWydeagnvyvgrnedev 454
Cdd:cd00812 127 KLLDQWFLKYSEteWKEKLLKDLEK--LDGWPEEVRAM----QENWIG--CSRQRYWGTPIP-W---------------- 181
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 455 rkennlgadvvlrqdEDVLDTWFSSALWTF-------STLGWPENTDALRQ----FHPTSVMVSGFDII----FFWIarm 519
Cdd:cd00812 182 ---------------TDTMESLSDSTWYYArytdahnLEQPYEGDLEFDREefeyWYPVDIYIGGKEHApnhlLYSR--- 243
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|.
gi 446338537 520 imMTMHFIKDENGKPQVPFHTVYMTGLIRDdEGQKMSKSKGNVIDPLDMVD 570
Cdd:cd00812 244 --FNHKALFDEGLVTDEPPKGLIVQGMVLL-EGEKMSKSKGNVVTPDEAIK 291
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
42-170 |
3.21e-08 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 56.39 E-value: 3.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 42 PNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGIATQMVverkiAAEEGKTRHDYGRE--AFIDKIWEWka 119
Cdd:cd00814 9 PYVNGVPHLGHLYGTVLADVFARYQRLRGYDVLFVTGTDEHGTKIEQK-----AEEEGVTPQELCDKyhEIFKDLFKW-- 81
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446338537 120 esggtitrqmrrLGNSVDwereRF--TMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:cd00814 82 ------------LNISFD----YFirTTSPRHKEIVQEFFKKLYENGYIYEGE 118
|
|
| PRK12267 |
PRK12267 |
methionyl-tRNA synthetase; Reviewed |
44-170 |
1.72e-07 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 237028 [Multi-domain] Cd Length: 648 Bit Score: 55.19 E-value: 1.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 44 VTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAGiatQMVVErkIAAEEGKTrhdygREAFIDKIwewkaeSGG 123
Cdd:PRK12267 15 PNGKPHIGHAYTTIAADALARYKRLQGYDVFFLTGTDEHG---QKIQQ--AAEKAGKT-----PQEYVDEI------SAG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446338537 124 tITRQMRRLGNSVDwereRF--TMDEGLSNAVKEVFVRLYKEDLIYRGK 170
Cdd:PRK12267 79 -FKELWKKLDISYD----KFirTTDERHKKVVQKIFEKLYEQGDIYKGE 122
|
|
| MetRS_core |
cd00814 |
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) ... |
379-570 |
1.90e-07 |
|
catalytic core domain of methioninyl-tRNA synthetases; Methionine tRNA synthetase (MetRS) catalytic core domain. This class I enzyme aminoacylates the 2'-OH of the nucleotide at the 3' of the appropriate tRNA. MetRS, which consists of the core domain and an anti-codon binding domain, functions as a monomer. However, in some species the anti-codon binding domain is followed by an EMAP domain. In this case, MetRS functions as a homodimer. The core domain is based on the Rossman fold and is responsible for the ATP-dependent formation of the enzyme bound aminoacyl-adenylate. It contains the characteristic class I HIGH and KMSKS motifs, which are involved in ATP binding. As a result of a deletion event, MetRS has a significantly shorter core domain insertion than IleRS, ValRS, and LeuR. Consequently, the MetRS insertion lacks the editing function.
Pssm-ID: 173907 [Multi-domain] Cd Length: 319 Bit Score: 54.07 E-value: 1.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 379 TDQWYVRADVLAKPAVEAVENGDIQFVPKQYENMYFSWMRD-IQDWCISRQLW-WGHRIPAwyDEAGNVYVgrnedevrk 456
Cdd:cd00814 137 EEHYFFRLSKFQDRLLEWLEKNPDFIWPENARNEVLSWLKEgLKDLSITRDLFdWGIPVPL--DPGKVIYV--------- 205
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 457 ennlgadvvlrqdedvldtWFssalwtfstlgwpentDALRQFhpTSVMVSGFDIIFFWIARMIMMT--MHFIkdenGKP 534
Cdd:cd00814 206 -------------------WF----------------DALIGY--ISATGYYNEEWGNSWWWKDGWPelVHFI----GKD 244
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 446338537 535 QVPFHTVYMTGLIRD----------------DEGQKMSKSKGNVIDPLDMVD 570
Cdd:cd00814 245 IIRFHAIYWPAMLLGaglplptrivahgyltVEGKKMSKSRGNVVDPDDLLE 296
|
|
| PLN02224 |
PLN02224 |
methionine-tRNA ligase |
33-169 |
2.69e-05 |
|
methionine-tRNA ligase
Pssm-ID: 177869 [Multi-domain] Cd Length: 616 Bit Score: 48.17 E-value: 2.69e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 33 ESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTLWQVGTDHAG--IATQmvverkiAAEEGKTrhdygreaf 110
Cdd:PLN02224 69 DTFVLTTPLYYVNAPPHMGSAYTTIAADSIARFQRLLGKKVIFITGTDEHGekIATS-------AAANGRN--------- 132
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446338537 111 idkiwewKAESGGTITRQMRRLGNSVDWERERF--TMDEGLSNAVKEVFVRLYKEDLIYRG 169
Cdd:PLN02224 133 -------PPEHCDIISQSYRTLWKDLDIAYDKFirTTDPKHEAIVKEFYARVFANGDIYRA 186
|
|
| lysK |
PRK00750 |
lysyl-tRNA synthetase; Reviewed |
515-578 |
3.05e-05 |
|
lysyl-tRNA synthetase; Reviewed
Pssm-ID: 234829 [Multi-domain] Cd Length: 510 Bit Score: 47.50 E-value: 3.05e-05
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446338537 515 WIARMIMmtmhfikdeNGKPQVPFhtVYmtGLIRDDEGQKMSKSKGNVIDPLDMVDgISLPELL 578
Cdd:PRK00750 254 KIAREIL---------GGEPPEPF--VY--ELFLDKKGEKISKSKGNVITIEDWLE-YAPPESL 303
|
|
| LysS |
COG1384 |
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA ... |
531-578 |
4.76e-04 |
|
Lysyl-tRNA synthetase, class I [Translation, ribosomal structure and biogenesis]; Lysyl-tRNA synthetase, class I is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 440994 [Multi-domain] Cd Length: 525 Bit Score: 44.03 E-value: 4.76e-04
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 446338537 531 NGKPqvPFHTVYmtGLIRDDEGQKMSKSKGNVIDPLDMVDGISlPELL 578
Cdd:COG1384 268 GGEP--PEGFVY--ELFLDENGEKISKSKGNGLTVEEWLEYAE-PESL 310
|
|
| argS |
PRK01611 |
arginyl-tRNA synthetase; Reviewed |
516-637 |
7.52e-04 |
|
arginyl-tRNA synthetase; Reviewed
Pssm-ID: 234964 [Multi-domain] Cd Length: 507 Bit Score: 43.22 E-value: 7.52e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 516 IARM--IMMTMHFIKDengKPQVPFHtvYMTGLIRDDEGQKMSKSKGNVIDpLDmvdgislpELLEKRTGnmmqpqladk 593
Cdd:PRK01611 287 FKRLkaALKALGYDPD---ALEVLLH--QMVGLVRGGEGVKMSTRAGNVVT-LD--------DLLDEAVG---------- 342
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446338537 594 iRKRTEKQFPNGIEPHGTDALRFtlaALASTGRD----INWD-MKRLEG 637
Cdd:PRK01611 343 -RARELIEEKEIAEAVGIDAVRY---FDLSRSRDkdldFDLDlALSFEG 387
|
|
| PLN02959 |
PLN02959 |
aminoacyl-tRNA ligase |
9-74 |
7.80e-04 |
|
aminoacyl-tRNA ligase
Pssm-ID: 215518 [Multi-domain] Cd Length: 1084 Bit Score: 43.52 E-value: 7.80e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 9 DIEQPLYEHWEKQGYFKPN----GDESQESFCIMIPPPNVTGSLHMGHAFQQTIMDTMIRYQRMQGKNTL 74
Cdd:PLN02959 17 EIEVAVQKWWEEEKVFEAEagdePPKPGEKFFGNFPYPYMNGLLHLGHAFSLSKLEFAAAYHRLRGANVL 86
|
|
| Anticodon_Ia_Met |
cd07957 |
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA ... |
669-763 |
1.31e-03 |
|
Anticodon-binding domain of methionyl tRNA synthetases; This domain is found in methionyl tRNA synthetases (MetRS), which belong to the class Ia aminoacyl tRNA synthetases. It lies C-terminal to the catalytic core domain, and recognizes and specifically binds to the tRNA anticodon (CAU). MetRS catalyzes the transfer of methionine to the 3'-end of its tRNA.
Pssm-ID: 153411 [Multi-domain] Cd Length: 129 Bit Score: 39.78 E-value: 1.31e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 669 TLSLADRWILAEFNQTIKAYREALDSFRFDIAAGILYEFTW--NQfcdwYLELTKP--VMNGGTEAELrgtRHTLVTVLE 744
Cdd:cd07957 33 GLTEEDEELLEEAEELLEEVAEAMEELEFRKALEEIMELARaaNK----YIDETAPwkLAKEEDPERL---ATVLYVLLE 105
|
90 100
....*....|....*....|..
gi 446338537 745 GLLRLA---HPIIPFITETIWQ 763
Cdd:cd07957 106 LLRILAillSPFMPETAEKILD 127
|
|
| metG |
PRK00133 |
methionyl-tRNA synthetase; Reviewed |
42-116 |
1.35e-03 |
|
methionyl-tRNA synthetase; Reviewed
Pssm-ID: 234655 [Multi-domain] Cd Length: 673 Bit Score: 42.45 E-value: 1.35e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446338537 42 PNVTGSLHMGHAFQ--QTimDTMIRYQRMQGKNTLWQVGTDHAGIATqMVVerkiAAEEGKTrhdygREAFIDKIWE 116
Cdd:PRK00133 11 PYANGPIHLGHLVEyiQA--DIWVRYQRMRGHEVLFVCADDAHGTPI-MLK----AEKEGIT-----PEELIARYHA 75
|
|
| tRNA-synt_1f |
pfam01921 |
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from ... |
531-578 |
1.39e-03 |
|
tRNA synthetases class I (K); This family includes only lysyl tRNA synthetases from prokaryotes.
Pssm-ID: 396483 Cd Length: 357 Bit Score: 41.86 E-value: 1.39e-03
10 20 30 40
....*....|....*....|....*....|....*....|....*...
gi 446338537 531 NGKPQVPFhtvyMTGLIRDDEGQKMSKSKGNVIDPLDMVDgISLPELL 578
Cdd:pfam01921 260 GGEPPEGF----PYELILLKGGGKMSSSKGNVITPEDWLE-YAPPESL 302
|
|
| ArgS |
COG0018 |
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA ... |
545-637 |
5.57e-03 |
|
Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Arginyl-tRNA synthetase is part of the Pathway/BioSystem: Aminoacyl-tRNA synthetases
Pssm-ID: 439789 [Multi-domain] Cd Length: 574 Bit Score: 40.52 E-value: 5.57e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446338537 545 GLIRDDEGQKMSKSKGNVIDpLDmvdgislpELLEkrtgnMMQPQLADKIRKRTEKQFPNGIEPHGTDALRFtlaALAST 624
Cdd:COG0018 370 GMVNLRDGEKMSTRAGTVVT-LD--------DLLD-----EAVERAREIIEEKSEEEKEEIAEQVGIDAVRY---FDLSR 432
|
90
....*....|....*...
gi 446338537 625 GR----DINWD-MKRLEG 637
Cdd:COG0018 433 SRdkdlDFDLDlALSFEG 450
|
|
| |
