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Conserved domains on  [gi|446319562|ref|WP_000397417|]
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multidrug efflux transporter transcriptional repressor MepR [Staphylococcus aureus]

Protein Classification

MarR family winged helix-turn-helix transcriptional regulator( domain architecture ID 11448790)

MarR family winged helix-turn-helix (wHTH) transcriptional regulator similar to Bacillus thuringiensis DNA-binding transcriptional repressor TubR, a DNA-binding protein that is part of the type III plasmid partition system used to ensure correct segregation of the pBtoxis plasmid

Gene Ontology:  GO:0006355|GO:0003700
PubMed:  10498949|28670937
SCOP:  4000246

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-137 5.93e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


:

Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 95.04  E-value: 5.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446319562   7 YLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLyaHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDT 86
Cdd:COG1846   14 LLLRRLARALRRALDRALAELGLTPAQFRVLAAL--AEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446319562  87 RRKNIGLTTSGIKLVEVFTSIFDEMEQTLVSQLSEEENEQMKANLTKMLSS 137
Cdd:COG1846   92 RAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-137 5.93e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 95.04  E-value: 5.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446319562   7 YLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLyaHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDT 86
Cdd:COG1846   14 LLLRRLARALRRALDRALAELGLTPAQFRVLAAL--AEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446319562  87 RRKNIGLTTSGIKLVEVFTSIFDEMEQTLVSQLSEEENEQMKANLTKMLSS 137
Cdd:COG1846   92 RAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-123 4.95e-18

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 73.40  E-value: 4.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446319562    24 LEQFDITNEQGHTLGYLyaHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEV 103
Cdd:smart00347   3 LKPLGLTPTQFLVLRIL--YEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|
gi 446319562   104 FTSIFDEMEQTLVSQLSEEE 123
Cdd:smart00347  81 LLEARSETLAELLAGLTAEE 100
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-88 3.60e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 54.90  E-value: 3.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446319562   27 FDITNEQGHTLGYLYAHqqDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRR 88
Cdd:pfam12802   1 LGLTPAQFRVLLALARN--PGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 40-84 3.73e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 3.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446319562  40 LYAHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQ 84
Cdd:cd00090   13 LRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
 
Name Accession Description Interval E-value
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
7-137 5.93e-26

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 95.04  E-value: 5.93e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446319562   7 YLFRMISHEMKQKADQKLEQFDITNEQGHTLGYLyaHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDT 86
Cdd:COG1846   14 LLLRRLARALRRALDRALAELGLTPAQFRVLAAL--AEAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDR 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446319562  87 RRKNIGLTTSGIKLVEVFTSIFDEMEQTLVSQLSEEENEQMKANLTKMLSS 137
Cdd:COG1846   92 RAVLVRLTEKGRALLEEARPALEALLAELLAGLSEEELEALLRLLRRLAEN 142
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
24-123 4.95e-18

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 73.40  E-value: 4.95e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446319562    24 LEQFDITNEQGHTLGYLyaHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSGIKLVEV 103
Cdd:smart00347   3 LKPLGLTPTQFLVLRIL--YEEGPLSVSELAKRLGVSPSTVTRVLDRLEKKGLVRREPSPEDRRSVLVSLTEEGRELIEQ 80

                           90       100
                   ....*....|....*....|
gi 446319562   104 FTSIFDEMEQTLVSQLSEEE 123
Cdd:smart00347  81 LLEARSETLAELLAGLTAEE 100
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 27-88 3.60e-11

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 54.90  E-value: 3.60e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446319562   27 FDITNEQGHTLGYLYAHqqDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRR 88
Cdd:pfam12802   1 LGLTPAQFRVLLALARN--PGLTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
MarR pfam01047
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 29-89 2.25e-06

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 426012 [Multi-domain]  Cd Length: 59  Bit Score: 42.15  E-value: 2.25e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446319562   29 ITNEQGHTLGYLYahQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRRK 89
Cdd:pfam01047   1 LTLTQFHILRILY--EHGPLTVSELAEKLGVSKSTVTRVLDRLEKKGLIERSRSPEDRREV 59
MntR COG1321
Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];
39-104 3.05e-06

Mn-dependent transcriptional regulator MntR, DtxR family [Transcription];


Pssm-ID: 440932 [Multi-domain]  Cd Length: 135  Bit Score: 43.65  E-value: 3.05e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446319562  39 YLYAHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRyvdaqdTRRKNIGLTTSGIK----------LVEVF 104
Cdd:COG1321   16 YELSEEGGPVRTSDIAERLGVSPPSVTEMLKKLEEKGLVEY------EPYGGITLTEEGRElalrivrrhrLLERF 85
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
37-79 8.77e-04

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 37.17  E-value: 8.77e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 446319562  37 LGYLYAHqqDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYR 79
Cdd:COG3398  103 LLYLLEN--PGATNKELAEELGISRSTVSWHLKRLEEDGLVER 143
HTH_27 pfam13463
Winged helix DNA-binding domain;
43-97 9.19e-04

Winged helix DNA-binding domain;


Pssm-ID: 433228 [Multi-domain]  Cd Length: 68  Bit Score: 35.73  E-value: 9.19e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 446319562   43 HQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRRKNIGLTTSG 97
Cdd:pfam13463  14 HRGDPKTLADICFRLNVEDSHVSYSLKKLTEAGLVEREGSEEDGRETRVRLTAKG 68
Lrp COG1522
DNA-binding transcriptional regulator, Lrp family [Transcription];
44-115 1.72e-03

DNA-binding transcriptional regulator, Lrp family [Transcription];


Pssm-ID: 441131 [Multi-domain]  Cd Length: 138  Bit Score: 36.29  E-value: 1.72e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446319562  44 QQDG-LTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVdAqDTRRKNIGLTTSGIKLVEVFTSIFDEMEQTL 115
Cdd:COG1522   15 QEDGrLSFAELAERVGLSESTVLRRVRRLEEAGVIRGYG-A-VVDPEKLGLGVTAFVEVKVPPHRLDEFAEAL 85
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 40-84 3.73e-03

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 34.20  E-value: 3.73e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 446319562  40 LYAHQQDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQ 84
Cdd:cd00090   13 LRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGR 57
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
34-135 4.29e-03

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 35.29  E-value: 4.29e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446319562  34 GHTLGYLYAHQqDGLTQNDIAKALQRTGPTVSNLLRNLERKKLIYRYVDAQDTRR-----KNIglttsgiklVEVFTSIF 108
Cdd:COG1510   30 GRIYALLYLSD-EPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKPGDRKDyfraeKDV---------WELFRRVF 99

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 446319562 109 DEMEQTLVSQLSE------------EENEQMKANLTKML 135
Cdd:COG1510  100 RERLRREIDPTLEllrealeeledsEEAEEARERLEELR 138
COG2512 COG2512
Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain ...
 48-80 6.30e-03

Predicted transcriptional regulator, contains CW (cell wall-binding) repeats and an HTH domain [General function prediction only];


Pssm-ID: 442002 [Multi-domain]  Cd Length: 80  Bit Score: 33.73  E-value: 6.30e-03
                         10        20        30
                 ....*....|....*....|....*....|...
gi 446319562  48 LTQNDIAKALQRTGPTVSNLLRNLERKKLIYRY 80
Cdd:COG2512   31 MTQSEIVKETGWSKSKVSRLLSRLEERGLIEKE 63
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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