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Conserved domains on  [gi|446317309|ref|WP_000395164|]
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MULTISPECIES: monovalent cation:proton antiporter family protein [Staphylococcus]

Protein Classification

monovalent cation:proton antiporter family protein( domain architecture ID 11422111)

monovalent cation:proton antiporter family protein such as Na/H antiporters which are key transporters in maintaining the pH of actively metabolising cells, and glutathione-regulated potassium-efflux system proteins that confer protection against electrophiles and catalyzes K+/H+ antiport

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 3.10e-67

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


:

Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 223.87  E-value: 3.10e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  83 KRArqgqnndessipgHLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475   83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGLSLAA--ALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 163 ILLVAVLADLVTMILLTVYGAINGQG---GSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475  148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 240 LVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIPILIVAFIV 319
Cdd:COG0475  228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446317309 320 SKLIPVMFIRRWF--DMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLFPV 393
Cdd:COG0475  304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
TrkA super family cl33955
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 315-595 1.67e-17

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


The actual alignment was detected with superfamily member COG0569:

Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 83.58  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 315 VAFIVSKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPII----FKKL 390
Cdd:COG0569    8 LVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLealrRRRM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 391 FPVPDEFNRKIEVslIGKNQLTIPIAQNLTSQLYDVTLYyRKDLSDRRQLSDDITMIEIAD-YEQDVLERLGLFDRDIVV 469
Cdd:COG0569   88 ERGIKKLKMHVII--IGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIEDADAVI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 470 CATNDDDINRKVAKLAKAHQVERVICRLESTTDDTELVDSGI-EIFSSYLSNKILLKGLIETPNMLNL--LSNVETSLYE 546
Cdd:COG0569  165 AATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGDAEIVE 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446317309 547 IQMLNY-KYENIQLR--NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLI 595
Cdd:COG0569  245 VTVPEGsPLVGKTLKelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 3.10e-67

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 223.87  E-value: 3.10e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  83 KRArqgqnndessipgHLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475   83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGLSLAA--ALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 163 ILLVAVLADLVTMILLTVYGAINGQG---GSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475  148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 240 LVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIPILIVAFIV 319
Cdd:COG0475  228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446317309 320 SKLIPVMFIRRWF--DMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLFPV 393
Cdd:COG0475  304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 6-391 3.20e-62

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 210.57  E-value: 3.20e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309    6 LVIVVLAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVER-DSILNILSTLGFIFLMFLSGLEIDFKAFKKDKR 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKL---PPIVGLIIAGILLGPSGLGLISEvDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   85 ArqgqnndessipgHLNLALTVFAFIMIISILLAYVFKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFIL 164
Cdd:pfam00999  78 S-------------ILLLALLGVLIPFVLIGLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  165 LVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQ-KLMDGTTQIGIRAVFALIILL 240
Cdd:pfam00999 145 GESVLNDGVAVVLLAVLLALaqgVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLItRFTDDDRELEVLLVLLLALLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  241 VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSLIkePKLLIIIPILIVAFIVS 320
Cdd:pfam00999 225 ALLAEALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNPLFFVLVGLSLDLSSLL--LSVWILVLLALVAILLG 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446317309  321 KLIPVMFIRR--WFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLF 391
Cdd:pfam00999 303 RFLGVFLLLRllGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPLL 375
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 11-296 1.92e-33

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 128.92  E-value: 1.92e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   11 LAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKDKRARQGQn 90
Cdd:TIGR00932   2 LAAVLAVPLSRRLGI---PSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   91 ndessipGHLNLALTVFAFIMiisiLLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLA 170
Cdd:TIGR00932  78 -------GVLQVLVPGVLLGL----LLGHLLGLALGA--AVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  171 DLVTMILLTVYGAINGQGGST---IWLIGILVVFTAISYILGVQF---KRMSFLQKlmDGTTQIGIRAVFALIILLVALA 244
Cdd:TIGR00932 145 DIAVVPLLALLPLLATSASTEhvaLALLLLKVFLAFLLLVLLGRWllrPVLRLTAE--LRPSELFTAGSLLLMFGSAYFA 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446317309  245 EGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGyGFFIPIFFIMVGVDLN 296
Cdd:TIGR00932 223 DLLGLSMALGAFLAGVVLSESEYRHKLESDLEPIG-GVLLPLFFISVGMSVD 273
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 315-595 1.67e-17

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 83.58  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 315 VAFIVSKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPII----FKKL 390
Cdd:COG0569    8 LVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLealrRRRM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 391 FPVPDEFNRKIEVslIGKNQLTIPIAQNLTSQLYDVTLYyRKDLSDRRQLSDDITMIEIAD-YEQDVLERLGLFDRDIVV 469
Cdd:COG0569   88 ERGIKKLKMHVII--IGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIEDADAVI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 470 CATNDDDINRKVAKLAKAHQVERVICRLESTTDDTELVDSGI-EIFSSYLSNKILLKGLIETPNMLNL--LSNVETSLYE 546
Cdd:COG0569  165 AATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGDAEIVE 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446317309 547 IQMLNY-KYENIQLR--NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLI 595
Cdd:COG0569  245 VTVPEGsPLVGKTLKelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-386 1.16e-12

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 71.07  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   4 LSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDS----------ILNILSTLGFIFLMFLSGLE 73
Cdd:PLN03159  46 LQLTLVVVTTRLLVFILKPFR---QPRVISEILGGVILGPSVLGQSEVFAntifplrsvmVLETMANLGLLYFLFLVGVE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  74 IDFKAFKKD-KRArqgqnndessipghLNLALTVFAFIMIISILLAYVF----KWLGLVDDVLLMVIIISTISLGVVVPT 148
Cdd:PLN03159 123 MDISVIRRTgKKA--------------LAIAIAGMALPFCIGLAFSFIFhqvsRNVHQGTFILFLGVALSVTAFPVLARI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 149 LKEMNIMRTTIGQFILLVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYIlgVQFKRMSFLQKLM--- 222
Cdd:PLN03159 189 LAEIKLINTELGRIAMSAALVNDMCAWILLALAIALaenDSTSLASLWVLLSSVAFVLFCFY--VVRPGIWWIIRRTpeg 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 223 DGTTQIGIRAVFALIILLVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIpSLIK 302
Cdd:PLN03159 267 ETFSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNV-TKIQ 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 303 EPKLLIIIPILIVAFIVSKLIPVMFIRRWFDM--KTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVI-T 379
Cdd:PLN03159 346 GPATWGLLVLVIIMASAGKIMGTIIIAFFYTMpfREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAmT 425


                 ....*..
gi 446317309 380 CVFVPII 386
Cdd:PLN03159 426 ALITPVV 432
trkA PRK09496
Trk system potassium transporter TrkA;
454-608 2.19e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 56.67  E-value: 2.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 454 QDVLERLGLFDRDIVVCATNDDDINRKVAKLAKAHQVERVICRLESTtDDTELVDS-GIEIfssYLS------NKIL--- 523
Cdd:PRK09496 287 QELLEEEGIDEADAFIALTNDDEANILSSLLAKRLGAKKVIALVNRP-AYVDLVEGlGIDI---AISprqataSEILrhv 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 524 LKGLIETpnmLNLLSNVETSLYEIQMLNY-KYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIV-TGAKE 601
Cdd:PRK09496 363 RRGDIVA---VHSLRRGAAEAIEAVAHETsKVVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVfVLDKK 439


                 ....*..
gi 446317309 602 YVDELKQ 608
Cdd:PRK09496 440 FVPDVEK 446
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 561-610 3.08e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 44.91  E-value: 3.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446317309  561 NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:pfam02080  21 NLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
 
Name Accession Description Interval E-value
KefB COG0475
Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism]; ...
 3-393 3.10e-67

Kef-type K+ transport system, membrane component KefB [Inorganic ion transport and metabolism];


Pssm-ID: 440243 [Multi-domain]  Cd Length: 384  Bit Score: 223.87  E-value: 3.10e-67
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG0475    6 LLQLGLLLLAAVLAGLLARRLG---LPSVLGYILAGILLGPSGLGLIEDSEALELLAELGVVLLLFLIGLELDLKRLRKM 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  83 KRArqgqnndessipgHLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQF 162
Cdd:COG0475   83 GRR-------------ALGIGLLQVLLPFLLGFLLALLLGLSLAA--ALFLGAALAATSTAIVLKVLKELGLLKTPLGQL 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 163 ILLVAVLADLVTMILLTVYGAINGQG---GSTIWLIGILVVFTAISYILGVQFKRMSFLQKLMDGTTQIGIRAVFALIIL 239
Cdd:COG0475  148 ILGVALFDDIAAILLLALVPALAGGGsvaGSLLLALLKALLFLALLLLVGRYLLRRLFRLVARTRSRELFLLFALLLVLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 240 LVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIPILIVAFIV 319
Cdd:COG0475  228 AAALAELLGLSAALGAFLAGLVLAESEYRHELEEKIEPFGD-LFLPLFFVSVGLSLDLSALLSNP---LLALLLVLAAIV 303

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446317309 320 SKLIPVMFIRRWF--DMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLFPV 393
Cdd:COG0475  304 GKLLGAYLAARLFglSRREALRIGLLLAPRGEFALVLASLGLSAGLISPELFAALVLVVLLTTLLTPLLLRLALRL 379
Na_H_Exchanger pfam00999
Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH ...
 6-391 3.20e-62

Sodium/hydrogen exchanger family; Na/H antiporters are key transporters in maintaining the pH of actively metabolising cells. The molecular mechanisms of antiport are unclear. These antiporters contain 10-12 transmembrane regions (M) at the amino-terminus and a large cytoplasmic region at the carboxyl terminus. The transmembrane regions M3-M12 share identity with other members of the family. The M6 and M7 regions are highly conserved. Thus, this is thought to be the region that is involved in the transport of sodium and hydrogen ions. The cytoplasmic region has little similarity throughout the family.


Pssm-ID: 425982 [Multi-domain]  Cd Length: 377  Bit Score: 210.57  E-value: 3.20e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309    6 LVIVVLAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVER-DSILNILSTLGFIFLMFLSGLEIDFKAFKKDKR 84
Cdd:pfam00999   1 IVLLILLALLAPLLARRLKL---PPIVGLIIAGILLGPSGLGLISEvDEDLEVLSNLGLPPLLFLAGLELDLRELRKNGG 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   85 ArqgqnndessipgHLNLALTVFAFIMIISILLAYVFKWLGLVDDVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFIL 164
Cdd:pfam00999  78 S-------------ILLLALLGVLIPFVLIGLLLYLLGLGIPLLEALLFGAILSATSPVVVLAILKELGRVPERLGTLLL 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  165 LVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYILGVQFKRMSFLQ-KLMDGTTQIGIRAVFALIILL 240
Cdd:pfam00999 145 GESVLNDGVAVVLLAVLLALaqgVGGGSDLGWLLLIFLVVAVGGLLLGLLIGWLLRLItRFTDDDRELEVLLVLLLALLA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  241 VALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIPSLIkePKLLIIIPILIVAFIVS 320
Cdd:pfam00999 225 ALLAEALGVSGILGAFLAGLVLSEYPFANKLSEKLEPFGYGLFNPLFFVLVGLSLDLSSLL--LSVWILVLLALVAILLG 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446317309  321 KLIPVMFIRR--WFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPIIFKKLF 391
Cdd:pfam00999 303 RFLGVFLLLRllGLSLREALIIGFGGLQRGAVSLALAAIGPLLGIIARELYPLLIVVVLFTVLVQGITLKPLL 375
2a37 TIGR00932
transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding ...
 11-296 1.92e-33

transporter, monovalent cation:proton antiporter-2 (CPA2) family; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273348 [Multi-domain]  Cd Length: 273  Bit Score: 128.92  E-value: 1.92e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   11 LAAFLTPIIVNRLNInflPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKDKRARQGQn 90
Cdd:TIGR00932   2 LAAVLAVPLSRRLGI---PSVLGYLLAGVLIGPSGLGLISNVEGVNHLAEFGVILLMFLIGLELDLERLWKLRKAAFGV- 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   91 ndessipGHLNLALTVFAFIMiisiLLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNIMRTTIGQFILLVAVLA 170
Cdd:TIGR00932  78 -------GVLQVLVPGVLLGL----LLGHLLGLALGA--AVVIGIILALSSTAVVVQVLKERGLLKTPFGQTVLGILLFQ 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  171 DLVTMILLTVYGAINGQGGST---IWLIGILVVFTAISYILGVQF---KRMSFLQKlmDGTTQIGIRAVFALIILLVALA 244
Cdd:TIGR00932 145 DIAVVPLLALLPLLATSASTEhvaLALLLLKVFLAFLLLVLLGRWllrPVLRLTAE--LRPSELFTAGSLLLMFGSAYFA 222

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 446317309  245 EGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGyGFFIPIFFIMVGVDLN 296
Cdd:TIGR00932 223 DLLGLSMALGAFLAGVVLSESEYRHKLESDLEPIG-GVLLPLFFISVGMSVD 273
RosB COG4651
Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and ...
 3-400 3.47e-27

Predicted Kef-type K+ transport protein, K+/H+ antiporter domain [Inorganic ion transport and metabolism];


Pssm-ID: 443689 [Multi-domain]  Cd Length: 564  Bit Score: 116.23  E-value: 3.47e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   3 FLSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKD 82
Cdd:COG4651    7 ITTIALILGLAAVLGLLAQRLR---QPPIVGYLLAGVLIGPFTPGLVADVELIEQLAEIGVILLLFGVGLEFSLKDLLAV 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  83 KRArqgqnndesSIPGhlnlALTVFAFIMIISILLAYVFKWlGLVDDVL--LMVIIISTIslgVVVPTLKEMNIMRTTIG 160
Cdd:COG4651   84 RKI---------ALPG----ALLQIALTTLLGFGIALLLGW-SLGESLVfgLALSLSSTV---VLLKLLEDRGELDTLHG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 161 QFILLVAVLADLVTMILLTVYGAINGQGGSTIWLIGI----LVVFTAISYILGvqfKRmsFLQKLMDGTTQIGIRAVFAL 236
Cdd:COG4651  147 RIAVGWLIVQDLAVVLMLVLLPALAGGGGGLLGTLGLtllkVALFVALMLVVG---RR--VIPWLLHRVARTRSRELFLL 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 237 IILLVALAEGVGAENI-----LGAFLAGVVVSLLNPDEEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLIKEPkllIIIP 311
Cdd:COG4651  222 AVLAICLGVAYLAALFglsfaLGAFLAGMVLAESEYSHQAAAELLPLRD-AFAVLFFVSVGMLFDPSFLLENP---LPVL 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 312 ILIVAFIVSKLIPVMFIRRWF--DMKTTIASAFLLT--STLSLVIAAAKISerLNAISAETSGILILSAVITCVFVPIIF 387
Cdd:COG4651  298 ALLLIVLIGKPLIAFLIVLALgyPLRTALLVGLSLAqiGEFSFILAALGLS--LGLLSEEAYQLILAVAILTIALSPYLI 375

                        410
                 ....*....|...
gi 446317309 388 KKLFPVPDEFNRK 400
Cdd:COG4651  376 ALADPLYARLERR 388
TrkA COG0569
Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion ...
 315-595 1.67e-17

Trk/Ktr K+ transport system regulatory component TrkA/KtrA/KtrC, RCK domain [Inorganic ion transport and metabolism, Signal transduction mechanisms];


Pssm-ID: 440335 [Multi-domain]  Cd Length: 296  Bit Score: 83.58  E-value: 1.67e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 315 VAFIVSKLIPVMFIRRWFDMKTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVITCVFVPII----FKKL 390
Cdd:COG0569    8 LVLLFAMGIEGLVLLDALYGLLITLTTVTTLGGGLLDPVTLVAAIFLIGVVIIPLGYTLITFGDAVLFGGLLealrRRRM 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 391 FPVPDEFNRKIEVslIGKNQLTIPIAQNLTSQLYDVTLYyRKDLSDRRQLSDDITMIEIAD-YEQDVLERLGLFDRDIVV 469
Cdd:COG0569   88 ERGIKKLKMHVII--IGAGRVGRSLARELEEEGHDVVVI-DKDPERVERLAEEDVLVIVGDaTDEEVLEEAGIEDADAVI 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 470 CATNDDDINRKVAKLAKAHQVERVICRLESTTDDTELVDSGI-EIFSSYLSNKILLKGLIETPNMLNL--LSNVETSLYE 546
Cdd:COG0569  165 AATGDDEANILACLLAKELGVPRIIARANDPEYADLLERLGAdVVISPERLAARRIARLLLRPGVLDVleLADGDAEIVE 244

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 446317309 547 IQMLNY-KYENIQLR--NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLI 595
Cdd:COG0569  245 VTVPEGsPLVGKTLKelDLRERYGVTVVAIKRGGEVIIPSGDTVLEAGDELI 296
PLN03159 PLN03159
cation/H(+) antiporter 15; Provisional
 4-386 1.16e-12

cation/H(+) antiporter 15; Provisional


Pssm-ID: 215608 [Multi-domain]  Cd Length: 832  Bit Score: 71.07  E-value: 1.16e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   4 LSLVIVVLAAFLTPIIVNRLNinfLPVVVAEILMGIVIGNSFLNIVERDS----------ILNILSTLGFIFLMFLSGLE 73
Cdd:PLN03159  46 LQLTLVVVTTRLLVFILKPFR---QPRVISEILGGVILGPSVLGQSEVFAntifplrsvmVLETMANLGLLYFLFLVGVE 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  74 IDFKAFKKD-KRArqgqnndessipghLNLALTVFAFIMIISILLAYVF----KWLGLVDDVLLMVIIISTISLGVVVPT 148
Cdd:PLN03159 123 MDISVIRRTgKKA--------------LAIAIAGMALPFCIGLAFSFIFhqvsRNVHQGTFILFLGVALSVTAFPVLARI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 149 LKEMNIMRTTIGQFILLVAVLADLVTMILLTVYGAI---NGQGGSTIWLIGILVVFTAISYIlgVQFKRMSFLQKLM--- 222
Cdd:PLN03159 189 LAEIKLINTELGRIAMSAALVNDMCAWILLALAIALaenDSTSLASLWVLLSSVAFVLFCFY--VVRPGIWWIIRRTpeg 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 223 DGTTQIGIRAVFALIILLVALAEGVGAENILGAFLAGVVVSLLNPDEEMVEKLDSFGYGFFIPIFFIMVGVDLNIpSLIK 302
Cdd:PLN03159 267 ETFSEFYICLILTGVMISGFITDAIGTHSVFGAFVFGLVIPNGPLGVTLIEKLEDFVSGLLLPLFFAISGLKTNV-TKIQ 345

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 303 EPKLLIIIPILIVAFIVSKLIPVMFIRRWFDM--KTTIASAFLLTSTLSLVIAAAKISERLNAISAETSGILILSAVI-T 379
Cdd:PLN03159 346 GPATWGLLVLVIIMASAGKIMGTIIIAFFYTMpfREGITLGFLMNTKGLVEMIVLNVGRDQEVLDDESFAVMVLVAVAmT 425


                 ....*..
gi 446317309 380 CVFVPII 386
Cdd:PLN03159 426 ALITPVV 432
PRK03659 PRK03659
glutathione-regulated potassium-efflux system protein KefB; Provisional
 2-297 2.69e-10

glutathione-regulated potassium-efflux system protein KefB; Provisional


Pssm-ID: 179625 [Multi-domain]  Cd Length: 601  Bit Score: 63.12  E-value: 2.69e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   2 EFLSLVIVVL-AAFLTPIIVNRLNINflpVVVAEILMGIVIGNSFLN-IVERDSILNiLSTLGFIFLMFLSGLEIDFKAF 79
Cdd:PRK03659   5 DLLTAGVLFLfAAVVAVPLAQRLGIG---AVLGYLLAGIAIGPWGLGfISDVDEILH-FSELGVVFLMFIIGLELNPSKL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  80 KKDKRarqgqnndesSIPGhLNLALTVFAFIMIISILLAYVFKWLGLVddVLLMVIIISTISLGVVVPTLKEMNimRTTI 159
Cdd:PRK03659  81 WQLRR----------SIFG-VGAAQVLLSAAVLAGLLMLTDFSWQAAV--VGGIGLAMSSTAMALQLMREKGMN--RSES 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 160 GQF---ILL---VAVLADLVTMILLTvygaiNGQGGSTIWLIGILVVFTAISYILGVQFkrmsFLQKLMDGTTQIGIRAV 233
Cdd:PRK03659 146 GQLgfsVLLfqdLAVIPALALVPLLA-----GSADEHFDWMKIGMKVLAFAGMLIGGRY----LLRPLFRFIAASGVREV 216

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446317309 234 FALIILLVALA-----EGVGAENILGAFLAGVvvsLLNPDE---EMVEKLDSFGyGFFIPIFFIMVGVDLNI 297
Cdd:PRK03659 217 FTAAALLLVLGsalfmDALGLSMALGTFIAGV---LLAESEyrhELEIAIEPFK-GLLLGLFFISVGMALNL 284
PRK03562 PRK03562
glutathione-regulated potassium-efflux system protein KefC; Provisional
 5-386 1.92e-09

glutathione-regulated potassium-efflux system protein KefC; Provisional


Pssm-ID: 235131 [Multi-domain]  Cd Length: 621  Bit Score: 60.39  E-value: 1.92e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   5 SLVIVVLAAFLTPIIVnRLNinfLPVVVAEILMGIVIGNSFLNIV-ERDSILNiLSTLGFIFLMFLSGLEIDFKAFKKDK 83
Cdd:PRK03562  10 ALIYLGAAVLIVPIAV-RLG---LGSVLGYLIAGCIIGPWGLRLVtDVESILH-FAEFGVVLMLFVIGLELDPQRLWKLR 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  84 RARQGQnndessipGHLNL---ALTVFAFIMIISIllayvfKWLglVDDVLLMVIIIStiSLGVVVPTLKEMNIMRTTIG 160
Cdd:PRK03562  85 RSIFGG--------GALQMvacGGLLGLFCMLLGL------RWQ--VALLIGLGLALS--STAIAMQAMNERNLMVTQMG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 161 Q--F-ILLVAVLA--DLVTMI-LLTVYGAinGQGGSTIWLIGILVVFTAISYILGVQFkrmsFLQKLMDGTTQIGIRAVF 234
Cdd:PRK03562 147 RsaFaILLFQDIAaiPLVAMIpLLAASGA--STTLGAFALSALKVAGALALVVLGGRY----VTRPALRFVARSGLREVF 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 235 -ALIILLV----ALAEGVGAENILGAFLAGVvvsLLNPDE---EMVEKLDSFGyGFFIPIFFIMVGVDLNIPSLIKEPkl 306
Cdd:PRK03562 221 tAVALFLVfgfgLLMEEVGLSMALGAFLAGV---LLASSEyrhALESDIEPFK-GLLLGLFFIAVGMSIDFGTLLENP-- 294

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 307 lIIIPILIVAFIVSKLIPVMFIRRWFDM--KTTIASAFLLT--STLSLVI--AAAKIserlNAISAETSGILILSAVITC 380
Cdd:PRK03562 295 -LRILILLLGFLAIKIAMLWLLARPLGVprKQRRWFAVLLGqgGEFAFVVfgAAQMA----NVLEPEWAKLLTLAVALSM 369


                 ....*.
gi 446317309 381 VFVPII 386
Cdd:PRK03562 370 AATPLL 375
trkA PRK09496
Trk system potassium transporter TrkA;
454-608 2.19e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 56.67  E-value: 2.19e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 454 QDVLERLGLFDRDIVVCATNDDDINRKVAKLAKAHQVERVICRLESTtDDTELVDS-GIEIfssYLS------NKIL--- 523
Cdd:PRK09496 287 QELLEEEGIDEADAFIALTNDDEANILSSLLAKRLGAKKVIALVNRP-AYVDLVEGlGIDI---AISprqataSEILrhv 362

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 524 LKGLIETpnmLNLLSNVETSLYEIQMLNY-KYENIQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIV-TGAKE 601
Cdd:PRK09496 363 RRGDIVA---VHSLRRGAAEAIEAVAHETsKVVGKPLKDLKLPKGVLIGAIVRGGEVIIPTGDTVIEPGDHVIVfVLDKK 439


                 ....*..
gi 446317309 602 YVDELKQ 608
Cdd:PRK09496 440 FVPDVEK 446
trkA PRK09496
Trk system potassium transporter TrkA;
415-610 8.13e-08

Trk system potassium transporter TrkA;


Pssm-ID: 236541 [Multi-domain]  Cd Length: 453  Bit Score: 55.13  E-value: 8.13e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 415 IAQNLTSQLYDVTLYyRKDLSDRRQLSD--DITMIE--IADYeqDVLERLGLFDRDIVVCATNDDDINRKVAKLAKA-HQ 489
Cdd:PRK09496  15 LAENLSGENNDVTVI-DTDEERLRRLQDrlDVRTVVgnGSSP--DVLREAGAEDADLLIAVTDSDETNMVACQIAKSlFG 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 490 VERVICRLEST--TDDTELVDS---GI-EIFSSYLSNKILLKGLIETPNMLN-------LLSNVETSLYEIQMLNYKYEN 556
Cdd:PRK09496  92 APTTIARVRNPeyAEYDKLFSKealGIdLLISPELLVAREIARLIEYPGALDveefadgRVQLVEVKVYEGSPLVGKPLS 171

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446317309 557 iQLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:PRK09496 172 -DLREHFPDIDVRVVAIFRGGRLIIPRGDTVIEAGDEVYFIGAREHIRAVMSEF 224
PRK10669 PRK10669
putative cation:proton antiport protein; Provisional
 13-390 8.64e-08

putative cation:proton antiport protein; Provisional


Pssm-ID: 182633 [Multi-domain]  Cd Length: 558  Bit Score: 55.11  E-value: 8.64e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  13 AFLTPIIVNRLNINFLpvvVAEILMGIVIGNSFLNIVERDSILNILSTLGFIFLMFLSGLEIDFKAFKKDKRArqgqnnd 92
Cdd:PRK10669  18 AFILGMLANRLRISPL---VGYLLAGVLAGPFTPGFVADTKLAPELAELGVILLMFGVGLHFSLKDLMAVKSI------- 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  93 esSIPGhlnlALTVFAFIMIISILLAYVFKW---LGLVDDVLLmviiiSTISLGVVVPTLKEMNIMRTTIGQFI---LLV 166
Cdd:PRK10669  88 --AIPG----AIAQIAVATLLGMALSAVLGWslmTGIVFGLCL-----STASTVVLLRALEERQLIDSQRGQIAigwLIV 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 167 AVLADLVTMILLTVYGAINGQGGSTI--------WLIGILVVFTAISYILGvqfKRMsfLQKLMDGTTQIGIRAVFALII 238
Cdd:PRK10669 157 EDLVMVLTLVLLPAVAGMMEQGDVGFatlavdlgITIGKVIAFIAIMMLVG---RRL--VPWILARSAATGSRELFTLSV 231

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 239 LLVALAEGVGAENI------LGAFLAGVVvslLNPDE-------EMVEKLDSFGYgffipIFFIMVGVDLNIPSLIKEPk 305
Cdd:PRK10669 232 LALALGIAFGAVELfdvsfaLGAFFAGMV---LNESElshraahDTLPLRDAFAV-----LFFVSVGMLFDPMILIQQP- 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 306 llIIIPILIVAFIVSKLIPVMFIRRWFD----MKTTIASAFLLTSTLSLVIAAAKISerLNAISAETSGILILSAVITCV 381
Cdd:PRK10669 303 --LAVLATLAIIVFGKSLAAFFLVRLFGhsrrTALTIAASLAQIGEFAFILAGLGMA--LNLLPQAGQNLVLAGAILSIM 378


                 ....*....
gi 446317309 382 FVPIIFKKL 390
Cdd:PRK10669 379 LNPVLFTLL 387
NhaP COG0025
NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];
3-494 5.73e-07

NhaP-type Na+/H+ or K+/H+ antiporter [Inorganic ion transport and metabolism];


Pssm-ID: 439796 [Multi-domain]  Cd Length: 506  Bit Score: 52.27  E-value: 5.73e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309   3 FLSLVIVVLAAFLTPIIVNRLNInflPVVVAEILMGIVIGnSFLNIVERDSILNI--LSTLGFIFLMFLSGLEIDFKAFK 80
Cdd:COG0025    4 LLLILLLLLLGLLSQWLARRLKL---PAPLLLLLAGILLG-PGLGLELDPELGDLepLLELFLPPLLFEAALNLDLRELR 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309  81 KDKRArqgqnndessipghlnlaLTVFAFI-MIISILL-AYVFKWLGLVDDVLLMVI--IISTISLGVVVPTLKEMNImR 156
Cdd:COG0025   80 RNGRP------------------ILRLAVVgVLLTTLAvALAAHWLLGLPLAAALLLgaILAPTDPVAVSPILRRLGV-P 140

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 157 TTIGQFILLVAVLAD-LVTMILLTVYGAINGQGGSTIWLIGILVVFTAISYILGVQFKRMS--FLQKLMDGTTQIGIraV 233
Cdd:COG0025  141 KRLRTILEGESLLNDaTALVLFVLALAAALGGGFSLGEALLDFLLAILGGILVGLLLGWLLgrLLRRLPDPLLEILL--T 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 234 FALIILLVALAEGVGAENILGAFLAGVVVSLLNPD-------EEMVEKLDSFGYgFFIPIFFIMVGVDLNIPSLikEPKL 306
Cdd:COG0025  219 LALPFLAYLLAEALHGSGVLAVVVAGLVLGNAGRRslspetrLQLLEFWETLEF-LLNSLLFVLLGAQLPLILL--GALG 295

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 307 LIIIPILIVAFIVSKLIPVMFIRRWFDMKTTIASAFLLTS-----TLSLVIAAAKISERLNAISAE------TSGILILS 375
Cdd:COG0025  296 LGGILLVLLALLVVRPLWVFLSLALRGSRLSWRERLFLSWggprgIVSLALALSLPLHGGAGFPGRdlilalAFGVILLT 375

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446317309 376 AVITCVFVPIIFKKLFPVPDEFNRKIEVSLIGKNQLTIPIAQNLTSQLYDVTLYYRKDLSDRRQLSD--DITMIEIADYE 453
Cdd:COG0025  376 LVLQGLTLPPLARRLGLREDEPEGEELEAALARAALLELLAAELLADDEEVVLRAARRARRRREAAEllSEEAEEELDED 455

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|.
gi 446317309 454 QDVLERLGLFDRDIVVCATNDDDINRKVAKLAKAHQVERVI 494
Cdd:COG0025  456 LLRLLLALLRLRLLNALAAARLERLLLRRRVEELLRLLERL 496
TrkA_C pfam02080
TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of ...
 561-610 3.08e-06

TrkA-C domain; This domain is often found next to the pfam02254 domain. The exact function of this domain is unknown. It has been suggested that it may bind an unidentified ligand. The domain is predicted to adopt an all beta structure.


Pssm-ID: 460440 [Multi-domain]  Cd Length: 70  Bit Score: 44.91  E-value: 3.08e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 446317309  561 NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:pfam02080  21 NLPERFGVRIVAIRRGGRLIIPSGDTVLEAGDRLLVIGTPDDLAALRELL 70
PRK05326 PRK05326
potassium/proton antiporter;
567-610 3.35e-04

potassium/proton antiporter;


Pssm-ID: 235410 [Multi-domain]  Cd Length: 562  Bit Score: 43.65  E-value: 3.35e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 446317309 567 DIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:PRK05326 440 GALIALIIRDGKLLVPTGSTRLKAGDVLLVLGPERDLPALERLF 483
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 564-610 3.87e-04

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 43.19  E-value: 3.87e-04
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 446317309 564 FGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:COG2985  226 LGTRVVISRIRRGGEIIVPTPDTVLQEGDIVLVVGTREALEAAEALL 272
NhaP2 COG3263
NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy ...
 558-608 4.64e-04

NhaP-type Na+/H+ and K+/H+ antiporter with C-terminal TrkAC and CorC domains [Energy production and conversion, Inorganic ion transport and metabolism];


Pssm-ID: 442494 [Multi-domain]  Cd Length: 502  Bit Score: 43.17  E-value: 4.64e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446317309 558 QLRNFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQ 608
Cdd:COG3263  430 TLRELRLPEGALVVLIVRDGELLVPRGSTRLQAGDQLLVLAPPEDLEALER 480
YbjL COG2985
Uncharacterized membrane protein YbjL, putative transporter [General function prediction only]; ...
 561-610 3.34e-03

Uncharacterized membrane protein YbjL, putative transporter [General function prediction only];


Pssm-ID: 442224 [Multi-domain]  Cd Length: 543  Bit Score: 40.49  E-value: 3.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446317309 561 NFPFGGDIIFVRIIRNNESIVPHGDTQLRYGDRLIVTGAKEYVDELKQEL 610
Cdd:COG2985  307 NLRNRFGVVITRVRRGGVELPATPDTVLQLGDRLTVVGPKEDVERVAKLL 356
NAD_binding_7 pfam13241
Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.
 450-490 3.74e-03

Putative NAD(P)-binding; This domain is found in fungi, plants, archaea and bacteria.


Pssm-ID: 433055 [Multi-domain]  Cd Length: 104  Bit Score: 37.07  E-value: 3.74e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 446317309  450 ADYEQDvlerlgLFDRDIVVCATNDDDINRKVAKLAKAHQV 490
Cdd:pfam13241  53 REFEGD------LDGADLVIAATDDPELNERIAALARARGI 87
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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