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Conserved domains on  [gi|446261188|ref|WP_000339043|]
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6-phospho-3-hexuloisomerase [Escherichia coli]

Protein Classification

SIS domain-containing protein( domain architecture ID 10141873)

SIS (sugar isomerase) domain-containing protein similar to Mycobacterium gastri 6-phospho-3-hexuloisomerase (PHI, EC 5.3.1.27) that catalyzes the isomerization between 3-hexulose 6-phosphate and fructose 6-phosphate

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 4-182 4.19e-80

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


:

Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 235.55  E-value: 4.19e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   4 KLYITEIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPNFGPGDLFI 83
Cdd:cd05005    1 MEYLSLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTPAIGPGDLLI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  84 VSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSVFRSAQPMASLYEQALLVIADALV 163
Cdd:cd05005   81 AISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSIQPLGTLFEQSALVFLDAVI 160

                        170
                 ....*....|....*....
gi 446261188 164 MKMAAESGAPESELFKRHA 182
Cdd:cd05005  161 AKLMEELGVSEEEMKKRHA 179
 
Name Accession Description Interval E-value
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 4-182 4.19e-80

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 235.55  E-value: 4.19e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   4 KLYITEIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPNFGPGDLFI 83
Cdd:cd05005    1 MEYLSLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTPAIGPGDLLI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  84 VSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSVFRSAQPMASLYEQALLVIADALV 163
Cdd:cd05005   81 AISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSIQPLGTLFEQSALVFLDAVI 160

                        170
                 ....*....|....*....
gi 446261188 164 MKMAAESGAPESELFKRHA 182
Cdd:cd05005  161 AKLMEELGVSEEEMKKRHA 179
RuMP_HxlB TIGR03127
6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase ...
 9-185 5.63e-65

6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin.


Pssm-ID: 132171 [Multi-domain]  Cd Length: 179  Bit Score: 197.53  E-value: 5.63e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188    9 EIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPNFGPGDLFIVSSAS 88
Cdd:TIGR03127   3 LILDEISQVASRIDEEELDKLADKIIKAKRIFVAGAGRSGLVGKAFAMRLMHLGFNVYVVGETTTPSIKKGDLLIAISGS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   89 GETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSVFRSAQPMASLYEQALLVIADALVMKMAA 168
Cdd:TIGR03127  83 GETESLVTVAKKAKEIGATVAAITTNPESTLGKLADVVVEIPAATKKDSEGNYKSIQPLGSLFEQSLLLFLDAVILKLMK 162

                         170
                  ....*....|....*..
gi 446261188  169 ESGAPESELFKRHANLE 185
Cdd:TIGR03127 163 KKGLDEEEMKKRHANLE 179
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 7-180 1.76e-20

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 85.75  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   7 ITEIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTE------TITPNFGPGD 80
Cdd:COG1737  105 LEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGdghlqaESAALLGPGD 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  81 LFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSvfrsaqPMASLYeqALLVIAD 160
Cdd:COG1737  185 VVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSS------AFSSRV--AQLALID 256

                        170       180
                 ....*....|....*....|
gi 446261188 161 ALVMKMAAESGAPESELFKR 180
Cdd:COG1737  257 ALAAAVAQRDGDKARERLER 276
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 33-132 5.36e-11

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 57.31  E-value: 5.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   33 IQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETIT------PNFGPGDLFIVSSASGETAQLVALAKKARQLGG 106
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASElrhgvlALVDEDDLVIAISYSGETKDLLAAAELAKARGA 81

                          90       100
                  ....*....|....*....|....*.
gi 446261188  107 AVAVLTTNRHATITEFVDVIVQINAP 132
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHVLYINAG 107
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
30-177 3.33e-05

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 43.37  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  30 IDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPN-----FGPGDLFIVSSASGETAQLVALAKKARQL 104
Cdd:PRK14101 462 IDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQAasaalLGKGDVIVAVSKSGRAPELLRVLDVAMQA 541

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446261188 105 GGAVAVLTTNRhATITEFVDVIVQINAPSKNQkdsvfrSAQPMASLYEQalLVIADALVMKMAAESGAPESEL 177
Cdd:PRK14101 542 GAKVIAITSSN-TPLAKRATVALETDHIEMRE------SQLSMISRILH--LVMIDILAVGVAIRRAAPNAEL 605
 
Name Accession Description Interval E-value
SIS_PHI cd05005
Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) ...
 4-182 4.19e-80

Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with formadelhyde to become hexulose-6-phosphate, which is then isomerized to fructose-6-phosphate by PHI.


Pssm-ID: 240138 [Multi-domain]  Cd Length: 179  Bit Score: 235.55  E-value: 4.19e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   4 KLYITEIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPNFGPGDLFI 83
Cdd:cd05005    1 MEYLSLILEEIENVADKIDEEELDKLISAILNAKRIFVYGAGRSGLVAKAFAMRLMHLGLNVYVVGETTTPAIGPGDLLI 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  84 VSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSVFRSAQPMASLYEQALLVIADALV 163
Cdd:cd05005   81 AISGSGETSSVVNAAEKAKKAGAKVVLITSNPDSPLAKLADVVVVIPAATKDDHGGEHKSIQPLGTLFEQSALVFLDAVI 160

                        170
                 ....*....|....*....
gi 446261188 164 MKMAAESGAPESELFKRHA 182
Cdd:cd05005  161 AKLMEELGVSEEEMKKRHA 179
RuMP_HxlB TIGR03127
6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase ...
 9-185 5.63e-65

6-phospho 3-hexuloisomerase; Members of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin.


Pssm-ID: 132171 [Multi-domain]  Cd Length: 179  Bit Score: 197.53  E-value: 5.63e-65
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188    9 EIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPNFGPGDLFIVSSAS 88
Cdd:TIGR03127   3 LILDEISQVASRIDEEELDKLADKIIKAKRIFVAGAGRSGLVGKAFAMRLMHLGFNVYVVGETTTPSIKKGDLLIAISGS 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   89 GETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSVFRSAQPMASLYEQALLVIADALVMKMAA 168
Cdd:TIGR03127  83 GETESLVTVAKKAKEIGATVAAITTNPESTLGKLADVVVEIPAATKKDSEGNYKSIQPLGSLFEQSLLLFLDAVILKLMK 162

                         170
                  ....*....|....*..
gi 446261188  169 ESGAPESELFKRHANLE 185
Cdd:TIGR03127 163 KKGLDEEEMKKRHANLE 179
RpiR COG1737
DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains ...
 7-180 1.76e-20

DNA-binding transcriptional regulator, MurR/RpiR family, contains HTH and SIS domains [Transcription];


Pssm-ID: 441343 [Multi-domain]  Cd Length: 286  Bit Score: 85.75  E-value: 1.76e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   7 ITEIINELTFVKDSIREDDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTE------TITPNFGPGD 80
Cdd:COG1737  105 LEAEIANLEETLELLDEEALERAVDLLAKARRIYIFGVGASAPVAEDLAYKLLRLGKNVVLLDGdghlqaESAALLGPGD 184

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  81 LFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSvfrsaqPMASLYeqALLVIAD 160
Cdd:COG1737  185 VVIAISFSGYTRETLEAARLAKERGAKVIAITDSPLSPLAKLADVVLYVPSEEPTLRSS------AFSSRV--AQLALID 256

                        170       180
                 ....*....|....*....|
gi 446261188 161 ALVMKMAAESGAPESELFKR 180
Cdd:COG1737  257 ALAAAVAQRDGDKARERLER 276
SIS_RpiR cd05013
RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many ...
 24-165 1.59e-18

RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate isomerases that catalyze the reversible reactions of ribose 5-phosphate into ribulose 5-phosphate.


Pssm-ID: 240144 [Multi-domain]  Cd Length: 139  Bit Score: 77.27  E-value: 1.59e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  24 DDCTKLIDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITP-----NFGPGDLFIVSSASGETAQLVALA 98
Cdd:cd05013    1 EALEKAVDLLAKARRIYIFGVGSSGLVAEYLAYKLLRLGKPVVLLSDPHLQlmsaaNLTPGDVVIAISFSGETKETVEAA 80

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446261188  99 KKARQLGGAVAVLTTNRHATITEFVDVIVQINAPSKNQKDSvfrsaqPMASLYeqALLVIADALVMK 165
Cdd:cd05013   81 EIAKERGAKVIAITDSANSPLAKLADIVLLVSSEEGDFRSS------AFSSRI--AQLALIDALFLA 139
SIS pfam01380
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 33-132 5.36e-11

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars. Presumably the SIS domains bind to the end-product of the pathway.


Pssm-ID: 426230 [Multi-domain]  Cd Length: 131  Bit Score: 57.31  E-value: 5.36e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188   33 IQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETIT------PNFGPGDLFIVSSASGETAQLVALAKKARQLGG 106
Cdd:pfam01380   2 LAKAKRIFVIGRGTSYAIALELALKFEEIGYKVVEVELASElrhgvlALVDEDDLVIAISYSGETKDLLAAAELAKARGA 81

                          90       100
                  ....*....|....*....|....*.
gi 446261188  107 AVAVLTTNRHATITEFVDVIVQINAP 132
Cdd:pfam01380  82 KIIAITDSPGSPLAREADHVLYINAG 107
SIS_1 cd05710
A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar ...
 74-128 3.26e-06

A subgroup of the SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240214 [Multi-domain]  Cd Length: 120  Bit Score: 44.10  E-value: 3.26e-06
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 446261188  74 PNFGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQ 128
Cdd:cd05710   43 KRLTEKSVVILASHSGNTKETVAAAKFAKEKGATVIGLTDDEDSPLAKLADYVIV 97
SIS cd04795
SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 39-112 6.69e-06

SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 240112 [Multi-domain]  Cd Length: 87  Bit Score: 42.75  E-value: 6.69e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  39 VFCYGLGRAGFSMKAFTMRLMHM-GKEVYFLTETITP------NFGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVL 111
Cdd:cd04795    1 IFVIGIGGSGAIAAYFALELLELtGIEVVALIATELEhasllsLLRKGDVVIALSYSGRTEELLAALEIAKELGIPVIAI 80


                 .
gi 446261188 112 T 112
Cdd:cd04795   81 T 81
SIS_Kpsf cd05014
KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ...
 78-164 1.04e-05

KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose 5-phosphate to arabinose 5-phosphate. This is the second step in the CMP-Kdo biosynthesis pathway.


Pssm-ID: 240145 [Multi-domain]  Cd Length: 128  Bit Score: 42.91  E-value: 1.04e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  78 PGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIvqINAPSKNQKDSvfRSAQPMASLyeQALLV 157
Cdd:cd05014   47 PGDVVIAISNSGETDELLNLLPHLKRRGAPIIAITGNPNSTLAKLSDVV--LDLPVEEEACP--LGLAPTTST--TAMLA 120


                 ....*..
gi 446261188 158 IADALVM 164
Cdd:cd05014  121 LGDALAV 127
SIS_GlmS_GlmD_1 cd05008
SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and ...
 73-131 2.85e-05

SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal glutaminase domain and two C-terminal SIS domains and catalyzes the first step in hexosamine metabolism, converting fructose 6-phosphate into glucosamine 6-phosphate using glutamine as nitrogen source. The glutaminase domain hydrolyzes glutamine to glutamate and ammonia. Ammonia is transferred through a channel to the isomerase domain for glucosamine 6-phosphate synthesis. The end product of the pathway is N-acetylglucosamine, which plays multiple roles in eukaryotic cells including being a building block of bacterial and fungal cell walls. In the absence of glutamine, GlmS catalyzes the isomerization of fructose 6-phosphate into glucose 6- phosphate (PGI-like activity). Glucosamine-6-phosphate deaminase (GlmD) contains two SIS domains and catalyzes the deamination and isomerization of glucosamine-6-phosphate into fructose-6-phosphate with the release of ammonia; in presence of high ammonia concentration, GlmD can catalyze the reverse reaction.


Pssm-ID: 240141 [Multi-domain]  Cd Length: 126  Bit Score: 41.71  E-value: 2.85e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446261188  73 TPNFGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINA 131
Cdd:cd05008   41 RPLLDEDTLVIAISQSGETADTLAALRLAKEKGAKTVAITNVVGSTLAREADYVLYLRA 99
PRK14101 PRK14101
bifunctional transcriptional regulator/glucokinase;
30-177 3.33e-05

bifunctional transcriptional regulator/glucokinase;


Pssm-ID: 184507 [Multi-domain]  Cd Length: 638  Bit Score: 43.37  E-value: 3.33e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  30 IDTIQQSQRVFCYGLGRAGFSMKAFTMRLMHMGKEVYFLTETITPN-----FGPGDLFIVSSASGETAQLVALAKKARQL 104
Cdd:PRK14101 462 IDILNNARRIEFYGLGNSNIVAQDAHYKFFRFGIPTIAYGDLYMQAasaalLGKGDVIVAVSKSGRAPELLRVLDVAMQA 541

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446261188 105 GGAVAVLTTNRhATITEFVDVIVQINAPSKNQkdsvfrSAQPMASLYEQalLVIADALVMKMAAESGAPESEL 177
Cdd:PRK14101 542 GAKVIAITSSN-TPLAKRATVALETDHIEMRE------SQLSMISRILH--LVMIDILAVGVAIRRAAPNAEL 605
PRK13938 PRK13938
phosphoheptose isomerase; Provisional
 78-135 1.36e-04

phosphoheptose isomerase; Provisional


Pssm-ID: 139997 [Multi-domain]  Cd Length: 196  Bit Score: 40.87  E-value: 1.36e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 446261188  78 PGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIvqINAPSKN 135
Cdd:PRK13938 113 PGDTLFAISTSGNSMSVLRAAKTARELGVTVVAMTGESGGQLAEFADFL--INVPSRD 168
SIS_2 pfam13580
SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and ...
 76-112 1.05e-03

SIS domain; SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars.


Pssm-ID: 433326 [Multi-domain]  Cd Length: 138  Bit Score: 37.57  E-value: 1.05e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 446261188   76 FGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVLT 112
Cdd:pfam13580 101 GRPGDVLIVISNSGINAVPVEAALEAKERGMKVIALT 137
PRK02947 PRK02947
sugar isomerase domain-containing protein;
76-132 1.20e-03

sugar isomerase domain-containing protein;


Pssm-ID: 179510 [Multi-domain]  Cd Length: 246  Bit Score: 38.31  E-value: 1.20e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446261188  76 FGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVLT--------TNRHA---TITEFVDVIVQINAP 132
Cdd:PRK02947 104 IRPGDVLIVVSNSGRNPVPIEMALEAKERGAKVIAVTslaysasvASRHSsgkRLAEVADVVLDNGAP 171
SIS_Etherase cd05007
N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ...
 75-127 2.18e-03

N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid carries a unique D-lactyl ether substituent at the C3 position. The etherase catalyzes the cleavage of the lactyl ether bond of N-acetylmuramic acid 6-phosphate.


Pssm-ID: 240140 [Multi-domain]  Cd Length: 257  Bit Score: 37.50  E-value: 2.18e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446261188  75 NFGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIV 127
Cdd:cd05007  115 NLTERDVVIGIAASGRTPYVLGALRYARARGALTIGIACNPGSPLLQLADIAI 167
AgaS COG2222
Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain ...
 79-131 2.24e-03

Fructoselysine-6-P-deglycase FrlB or related protein, duplicated sugar isomerase (SIS) domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441824 [Multi-domain]  Cd Length: 336  Bit Score: 37.57  E-value: 2.24e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 446261188  79 GDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQINA 131
Cdd:COG2222   83 GTLVVAISRSGNSPEVVAALELAKARGARTLAITNNPDSPLAEAADRVLPLPA 135
GlmS COG0449
Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase ...
 74-131 2.34e-03

Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440218 [Multi-domain]  Cd Length: 610  Bit Score: 37.68  E-value: 2.34e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446261188  74 PNFGPGDLFIVSSASGETAQ-LVALaKKARQLGGAVAVLTTNRHATITEFVDVIVQINA 131
Cdd:COG0449  337 PVVDPGTLVIAISQSGETADtLAAL-REAKEKGAKVLAICNVVGSTIARESDAVLYTHA 394
SIS_PGI_PMI_1 cd05017
The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the ...
 65-114 3.26e-03

The members of this protein family contain the SIS (Sugar ISomerase) domain and have both the phosphoglucose isomerase (PGI) and the phosphomannose isomerase (PMI) functions. These functions catalyze the reversible reactions of glucose 6-phosphate to fructose 6-phosphate, and mannose 6-phosphate to fructose 6-phosphate, respectively at an equal rate. This protein contains two SIS domains. This alignment is based on the first SIS domain.


Pssm-ID: 240148 [Multi-domain]  Cd Length: 119  Bit Score: 36.09  E-value: 3.26e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 446261188  65 VYFLTETItpnfGPGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTN 114
Cdd:cd05017   34 DYTLPAFV----DRKTLVIAVSYSGNTEETLSAVEQAKERGAKIVAITSG 79
GutQ COG0794
D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall ...
 78-164 4.61e-03

D-arabinose 5-phosphate isomerase GutQ [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 440557 [Multi-domain]  Cd Length: 317  Bit Score: 36.88  E-value: 4.61e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446261188  78 PGDLFIVSSASGETAQLVALAKKARQLGGAVAVLTTNRHATITEFVDVIVQInapsknqkdSVFRSA-----QPMASLye 152
Cdd:COG0794   91 PGDVVIAISNSGETEELLALLPLLKRLGVPLIAITGNPDSTLARAADVVLDL---------PVEREAcplnlAPTTST-- 159

                         90
                 ....*....|..
gi 446261188 153 QALLVIADALVM 164
Cdd:COG0794  160 TATLALGDALAV 171
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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