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Conserved domains on  [gi|446259331|ref|WP_000337186|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Enterobacteriaceae]

Protein Classification

helix-turn-helix domain-containing protein( domain architecture ID 10007349)

helix-turn-helix (HTH) domain-containing protein with an XRE (Xenobiotic Response Element) family HTH domain, binds DNA and may function as a transcriptional regulator

CATH:  1.10.260.40
Gene Ontology:  GO:0003677
PubMed:  2644244|15808743|8831795|10473770
SCOP:  4000362

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
6-71 6.81e-33

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


:

Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 107.61  E-value: 6.81e-33
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446259331  6 KARDWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRY 71
Cdd:COG3423   3 KKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRY 68
 
Name Accession Description Interval E-value
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
6-71 6.81e-33

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 107.61  E-value: 6.81e-33
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446259331  6 KARDWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRY 71
Cdd:COG3423   3 KKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRY 68
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
9-71 2.74e-32

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 106.16  E-value: 2.74e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446259331   9 DWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRY 71
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRY 63
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
9-72 1.17e-26

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 92.72  E-value: 1.17e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446259331  9 DWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRYQ 72
Cdd:PRK10344  7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYH 70
 
Name Accession Description Interval E-value
SfsB COG3423
Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];
6-71 6.81e-33

Predicted transcriptional regulator, lambda repressor-like DNA-binding domain [Transcription];


Pssm-ID: 442649 [Multi-domain]  Cd Length: 69  Bit Score: 107.61  E-value: 6.81e-33
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446259331  6 KARDWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRY 71
Cdd:COG3423   3 KKKDWHPADIKAALRKRGTSLAALAREAGLSSSTLSNALTRPWPKGERAIAEALGVPPEEIWPSRY 68
HTH_35 pfam13693
Winged helix-turn-helix DNA-binding;
9-71 2.74e-32

Winged helix-turn-helix DNA-binding;


Pssm-ID: 433408  Cd Length: 70  Bit Score: 106.16  E-value: 2.74e-32
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446259331   9 DWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRY 71
Cdd:pfam13693  1 DWHPADIKAALRKRGTTLAALSRSAGLSSSTLSNALTRPWPKGERIIAEALGVPPEEIWPSRY 63
PRK10344 PRK10344
DNA-binding transcriptional regulator SfsB;
9-72 1.17e-26

DNA-binding transcriptional regulator SfsB;


Pssm-ID: 182394  Cd Length: 92  Bit Score: 92.72  E-value: 1.17e-26
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446259331  9 DWHRADVIAGLKKRKLSLSALSRQFGYAPTTLANALERHWPKGEQIIANALETKPEVIWPSRYQ 72
Cdd:PRK10344  7 DWHPADIIAGLRKKGTSMAAESRRNGLSSSTLANALSRPWPKGEMIIAKALGTDPWVIWPSRYH 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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