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Conserved domains on  [gi|446194974|ref|WP_000272829|]
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MULTISPECIES: glutamate/aspartate ABC transporter permease GltK [Enterobacteriaceae]

Protein Classification

glutamate/aspartate ABC transporter permease GltK( domain architecture ID 11487652)

glutamate/aspartate ABC transporter permease GltK is part of the ABC transporter complex GltIJKL involved in glutamate and aspartate uptake

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
1-224 3.77e-137

glutamate/aspartate ABC transporter permease GltK;


:

Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 383.41  E-value: 3.77e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   1 MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVP 80
Cdd:PRK15107   1 MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  81 GFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLT 160
Cdd:PRK15107  81 GFLQNVLGLSPKTDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446194974 161 QGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA 224
Cdd:PRK15107 161 QGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKRTV 224
 
Name Accession Description Interval E-value
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
1-224 3.77e-137

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 383.41  E-value: 3.77e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   1 MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVP 80
Cdd:PRK15107   1 MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  81 GFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLT 160
Cdd:PRK15107  81 GFLQNVLGLSPKTDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446194974 161 QGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA 224
Cdd:PRK15107 161 QGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKRTV 224
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-224 1.02e-72

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 219.95  E-value: 1.02e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   2 YEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPG 81
Cdd:COG0765    1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  82 FlqnVLGLSPkndirLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQ 161
Cdd:COG0765   81 L---GIDLSP-----FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNE 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194974 162 GIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA 224
Cdd:COG0765  153 FISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLA 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 4-222 2.85e-26

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 100.70  E-value: 2.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974    4 FDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFl 83
Cdd:TIGR03003   1 WDWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   84 qnvlGLSPKndiRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGI 163
Cdd:TIGR03003  80 ----GIRLP---ALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLV 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446194974  164 VLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:TIGR03003 153 AMFKETPVLSAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 20-214 5.50e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.39  E-value: 5.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  20 LVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPkndirLIS 99
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGL-----GLP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974 100 AMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLAD 179
Cdd:cd06261   76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446194974 180 FFRTASTIGERDGTQVEMILFAGFVYFVISLSASL 214
Cdd:cd06261  156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-223 6.27e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.06  E-value: 6.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   34 GILWGTMLAVMRlssFAPVSWFAKAYVNVFRSIPlvmVLLWFYLIVPGFLQNVLGLSpkndirLISAMVAFSMFEAAYYS 113
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALP---SFVLAILLVVIAILSILGHG------ILPAIILALLGWAGYAR 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  114 EIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVL--SLADFFRTASTIGERD 191
Cdd:pfam00528  69 LIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgsWPGLGLLLIEAILGYD 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446194974  192 GTQ-VEMILFAGFVYFVISLSASLLVSYLKRRT 223
Cdd:pfam00528 149 YPEiQGPVLAAALILLLLNLLVDILQRLLDPRV 181
 
Name Accession Description Interval E-value
PRK15107 PRK15107
glutamate/aspartate ABC transporter permease GltK;
1-224 3.77e-137

glutamate/aspartate ABC transporter permease GltK;


Pssm-ID: 185062 [Multi-domain]  Cd Length: 224  Bit Score: 383.41  E-value: 3.77e-137
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   1 MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVP 80
Cdd:PRK15107   1 MYEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTILAVMRLSSFKPVAWFAKAYVNVFRSIPLVMVLLWFYLIVP 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  81 GFLQNVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLT 160
Cdd:PRK15107  81 GFLQNVLGLSPKTDIRLISAMVAFSMFEAAYYSEIIRAGIQSISRGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLT 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446194974 161 QGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA 224
Cdd:PRK15107 161 QGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKKRTV 224
HisM COG0765
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 2-224 1.02e-72

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 440528 [Multi-domain]  Cd Length: 218  Bit Score: 219.95  E-value: 1.02e-72
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   2 YEFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPG 81
Cdd:COG0765    1 MFFDFSVLLDYLPLLLEGLLVTLLLTVLAIVLGLVLGLLLALARLSPNPVLRWLATAYVEFFRGTPLLVQLFFIYFGLPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  82 FlqnVLGLSPkndirLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQ 161
Cdd:COG0765   81 L---GIDLSP-----FVAAVIALTLNSAAYLAEIVRAGIQSVPKGQWEAARALGLSRWQTMRRIILPQALRIILPPLGNE 152

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194974 162 GIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA 224
Cdd:COG0765  153 FISLLKDTSLVSVIGVPELTRAAQQIASRTFRPFEVYLVAALIYLVLTLPLSLLARRLERRLA 215
PRK15100 PRK15100
cystine ABC transporter permease;
9-222 1.20e-39

cystine ABC transporter permease;


Pssm-ID: 185055 [Multi-domain]  Cd Length: 220  Bit Score: 135.65  E-value: 1.20e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   9 IVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLlwfYLIVPGFLQNVLG 88
Cdd:PRK15100   8 VIDSAPFLLKGAGYTLQLSIGGMFFGLLLGFILALMRLSPIWPVRWLARFYVSIFRGTPLIAQL---FMIYYGLPQFGIE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  89 LSPkndirLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQD 168
Cdd:PRK15100  85 LDP-----IPAAMIGLSLNTAAYAAETLRAAISSIDKGQWEAAASIGMTRWQTLRRAILPQAARTALPPLSNSFISLVKD 159

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 446194974 169 TSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:PRK15100 160 TSLAATIQVPELFRQAQLITSRTLEVFTMYLAASLIYWIMATVLSALQNRFENQ 213
ArtM COG4160
ABC-type arginine/histidine transport system, permease component [Amino acid transport and ...
 4-222 5.05e-37

ABC-type arginine/histidine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443325 [Multi-domain]  Cd Length: 229  Bit Score: 129.06  E-value: 5.05e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   4 FDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLvmvLLWFYLIVPGFL 83
Cdd:COG4160    1 MDLDLLFEYLPLLLSGLPLTLQLLALSLLLGFLLAVPLALARASGNRLLRWPARGYIYVFRGTPL---LVQLFLIYYGLG 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  84 Q-NVLGLSPKNDI---RLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLL 159
Cdd:COG4160   78 QfEWVRESWLWPLlrdPWFCALLALTLNTAAYTAEIFRGAIRAVPKGEIEAARALGMSRWQTFRRIILPSALRRALPAYS 157

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194974 160 TQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:COG4160  158 NEVILMLKATALASTITVMDLTGVARRIYSRTYDPFEPFLIAALIYLVITFLLTRLFRLLERR 220
glnP PRK09494
glutamine ABC transporter permease protein; Reviewed
 3-222 5.18e-28

glutamine ABC transporter permease protein; Reviewed


Pssm-ID: 181907 [Multi-domain]  Cd Length: 219  Bit Score: 105.52  E-value: 5.18e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   3 EFDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGF 82
Cdd:PRK09494   2 QFDWSAIWPAIPLLLEGAKMTLWISVLGLAGGLVIGLLAGFARAYGGWIANHIALVFIELIRGTPIVVQVMFIYFALPMA 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  83 LQNVlglspknDIRLISAMVAFSMFEA-AYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQ 161
Cdd:PRK09494  82 FNDL-------RIDPFTAAVVTIMINSgAYIAEITRGAVLSIHKGFREAGLALGLSRRETLRYVIGPLALRRMLPPLGNQ 154

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446194974 162 GIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:PRK09494 155 WIISIKDTSLFIVIGVAELTRQGQEIIAGNFRALEIWSAVAVIYLIITLVLSFILRRLERR 215
ectoine_ehuD TIGR03003
ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are ...
 4-222 2.85e-26

ectoine/hydroxyectoine ABC transporter, permease protein EhuD; Members of this family are presumed to act as permease subunits of ectoine ABC transporters. Operons containing this gene also contain the other genes of the ABC transporter and typically are found next to either ectoine utilization or ectoine biosynthesis operons.


Pssm-ID: 132048 [Multi-domain]  Cd Length: 212  Bit Score: 100.70  E-value: 2.85e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974    4 FDWSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFl 83
Cdd:TIGR03003   1 WDWEFVRQILPTLIEGLKITILATALGFAIAAVLGLVFAILRRSAPTPISWPTSFVVEFIRGTPLLVQLYFLYYVLPDI- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   84 qnvlGLSPKndiRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGI 163
Cdd:TIGR03003  80 ----GIRLP---ALVAGVLGLGLHYATYAAEVYRAGIEAVPRGQWEAATALNLTARQTYRHIILPQAIPPIIPALGNYLV 152

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 446194974  164 VLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:TIGR03003 153 AMFKETPVLSAITVLELMNQAKSIGNSTFRYLEPMTLVGVFFLILSIISVFFLRRLEAR 211
BatB COG4597
ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; ...
 19-224 4.84e-23

ABC-type amino acid transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 443651 [Multi-domain]  Cd Length: 397  Bit Score: 95.60  E-value: 4.84e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  19 GLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIV----PG-----------FL 83
Cdd:COG4597   91 GLLNTLLVAVLGIVLATILGFLVGIARLSSNWLVSKLATVYVEIFRNIPLLLQIFFWYFAVlealPSprqslslfdgvFL 170

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  84 QN-----------------------------------------------------------------VLGLSPKNDI--- 95
Cdd:COG4597  171 NNrglylpapvfepgfgwvlaallaaivaafvlrrwarrrqeatgqrfpvwwislallvglpllaflLLGAPLSLDYpel 250

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  96 -------------RLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQG 162
Cdd:COG4597  251 kgfnfrggltlspEFVALLLALSLYTAAFIAEIVRAGIQAVSKGQTEAARALGLRPGQTLRLVVLPQALRVIIPPLTSQY 330

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446194974 163 IVLFQDTSLVYVLSLADFFRT-ASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRTA 224
Cdd:COG4597  331 LNLTKNSSLAVAIGYPDLVSVfAGTTLNQTGQAIEIIAITMAVYLTISLLISLLMNWYNRRVA 393
PRK11123 PRK11123
arginine ABC transporter permease ArtQ;
16-223 2.56e-21

arginine ABC transporter permease ArtQ;


Pssm-ID: 182979 [Multi-domain]  Cd Length: 238  Bit Score: 88.20  E-value: 2.56e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  16 LLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFY--------LIVPGFLQNVL 87
Cdd:PRK11123   7 LASAAGMTVGLAVCALIVGLALAMLFAVWESAKWRPVAWPGTALVTLLRGLPEILVVLFIYfgssqlllTLSDGFTLNLG 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  88 GLSPKNDIRL--------ISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLL 159
Cdd:PRK11123  87 FVQIPVQMDIenfevspfLCGVIALSLLYAAYASQTLRGALKAVPVGQWESGQALGLSKSAIFFRLVMPQMWRHALPGLG 166

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446194974 160 TQGIVLFQDTSLVYVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRRT 223
Cdd:PRK11123 167 NQWLVLLKDTALVSLISVNDLMLQTKSIATRTQEPFTWYIIAAAIYLVITLISQYILKRIELRA 230
HEQRo_perm_3TM TIGR01726
amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This ...
 12-118 7.99e-20

amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; This model represents one of several classes of multiple membrane spanning regions found immediately N-terminal to the domain described by pfam00528, binding-protein-dependent transport systems inner membrane component. The region covered by this model generally is predicted to contain three transmembrane helices. Substrate specificities attributed to members of this family include histidine, arginine, glutamine, glutamate, and (in Agrobacterium) the opines octopine and nopaline. [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 130787 [Multi-domain]  Cd Length: 99  Bit Score: 80.65  E-value: 7.99e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   12 SLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFlqnVLGLSP 91
Cdd:TIGR01726   1 NLPFLLKGLLLTLLLSVLSILLGLVLGLLLALLRLSGNRPLRWIATVYVELFRGTPLLVQLFFIYFGLPLI---GIRLSP 77

                          90       100
                  ....*....|....*....|....*..
gi 446194974   92 kndirLISAMVAFSMFEAAYYSEIIRA 118
Cdd:TIGR01726  78 -----LTAAVIALTLFYGAYLAEIFRG 99
PRK15135 PRK15135
histidine ABC transporter permease HisQ;
16-222 3.06e-15

histidine ABC transporter permease HisQ;


Pssm-ID: 185089 [Multi-domain]  Cd Length: 228  Bit Score: 71.75  E-value: 3.06e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  16 LLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIP-LVMVLLWFY--LIVPGFLQNVLGLSPK 92
Cdd:PRK15135   9 ILQGALVTLELALSSVVLAVIIGLIGAGGKLSQNRLLGLIFEGYTTLIRGVPdLVLMLLIFYglQIALNSVTEALGVGQI 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  93 NDIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLV 172
Cdd:PRK15135  89 DIDPMVAGIITLGFIYGAYFTETFRGAFMAVPKGHIEAATAFGFTRGQVFRRIMFPAMMRYALPGIGNNWQVILKATALV 168

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 446194974 173 YVLSLADFFRTASTIGERDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:PRK15135 169 SLLGLEDVVKATQLAGKSTWEPFYFAIVCGVIYLVFTTVSNGVLLWLERR 218
TM_PBP2 cd06261
Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 20-214 5.50e-15

Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The two ABCs bind and hydrolyze ATP and drive the transport reaction. For these transporters the ABCs and TMs are on independent polypeptide chains. These systems transport a diverse range of substrates. Most are specific for a single substrate or a group of related substrates; however some transporters are more promiscuous, transporting structurally diverse substrates such as the histidine/lysine and arginine transporter in Enterobacteriaceae. In the latter case, this is achieved through binding different PBPs with different specificities to the TMs. For other promiscuous transporters such as the multiple-sugar transporter Msm of Streptococcus mutans, the PBP has a wide substrate specificity. These transporters include the maltose-maltodextrin, phosphate and sulfate transporters, among others.


Pssm-ID: 119394 [Multi-domain]  Cd Length: 190  Bit Score: 70.39  E-value: 5.50e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  20 LVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPkndirLIS 99
Cdd:cd06261    1 LLNTLLLALIATLLALVLGLLLGIILARKRGKLDRLLRRIIDLLLSLPSLVLGLLLVLLFGVLLGWGILPGL-----GLP 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974 100 AMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVLSLAD 179
Cdd:cd06261   76 ALILALLLIAPFARLIRRAALESIPKDLVEAARALGASPWQIFRRIILPLALPPILTGLVLAFARALGEFALVSFLGGGE 155

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 446194974 180 FFRTASTIGERDGTQVEMILFAGFVYFVISLSASL 214
Cdd:cd06261  156 APGPGTGLLLIFAILFPGDLGVAAAVALILLLLSL 190
PRK15069 PRK15069
histidine ABC transporter permease HisM;
6-184 7.44e-15

histidine ABC transporter permease HisM;


Pssm-ID: 185029 [Multi-domain]  Cd Length: 234  Bit Score: 70.85  E-value: 7.44e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   6 WSSIVPSLPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFlqN 85
Cdd:PRK15069   9 WKALLWTDGYRFTGLAITLWLLVASVVIGFVLAVPLAIARVSSNKWIRFPVWLYTYVFRGTPLYVQLLVFYTGMYSL--E 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  86 VLGLSPKNDIRLISAM----VAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQ 161
Cdd:PRK15069  87 IVRGTDLLDAFFRSGLnctiLAFTLNTCAYTTEIFAGAIRSVPHGEIEAARAYGMSTFKLYRRIILPSALRRALPAYSNE 166

                        170       180
                 ....*....|....*....|...
gi 446194974 162 GIVLFQDTSLVYVLSLADFFRTA 184
Cdd:PRK15069 167 VILMLHATTLAFTATVPDILKIA 189
artM PRK11122
arginine ABC transporter permease ArtM;
13-222 9.65e-15

arginine ABC transporter permease ArtM;


Pssm-ID: 182978 [Multi-domain]  Cd Length: 222  Bit Score: 70.37  E-value: 9.65e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  13 LPYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAKAYVNVFRSIPLvmvLLWFYLIVPG-----FLQNVL 87
Cdd:PRK11122   5 LPELLKGLHTSLTLTVASLLVALVLALIFTIILTLKTPVLVWLVRGYITLFTGTPL---LVQIFLIYYGpgqfpWLQEYP 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  88 GLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKlIILPQAFRAMVPLLLTQGIVLFQ 167
Cdd:PRK11122  82 WLWHLLSQPWLCAMLALALNSAAYSTQLFYGAVRAIPEGQWQSCAALGMSKKQTLR-ILLPYAFKRALSSYSNEVVLVFK 160

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446194974 168 DTSLVYVLSLADFFRTASTIgerDGTQVEMILF--AGFVYFVISLSASLLVSYLKRR 222
Cdd:PRK11122 161 STSLAYTITLMDVMGYSQLL---YGRTYDVMVFgaAGIIYLVVNGLLTLLMRLIERK 214
BPD_transp_1 pfam00528
Binding-protein-dependent transport system inner membrane component; The alignments cover the ...
 34-223 6.27e-07

Binding-protein-dependent transport system inner membrane component; The alignments cover the most conserved region of the proteins, which is thought to be located in a cytoplasmic loop between two transmembrane domains. The members of this family have a variable number of transmembrane helices.


Pssm-ID: 334128 [Multi-domain]  Cd Length: 183  Bit Score: 48.06  E-value: 6.27e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   34 GILWGTMLAVMRlssFAPVSWFAKAYVNVFRSIPlvmVLLWFYLIVPGFLQNVLGLSpkndirLISAMVAFSMFEAAYYS 113
Cdd:pfam00528   1 GIPLGIIAALRR---GRRLDRLLRPLIDLLQALP---SFVLAILLVVIAILSILGHG------ILPAIILALLGWAGYAR 68

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  114 EIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMVPLLLTQGIVLFQDTSLVYVL--SLADFFRTASTIGERD 191
Cdd:pfam00528  69 LIRRAALRSLPSDLVEAARALGASRWQIFRKIILPNALPPILTGLALAFGGALGGAVLLEFLgsWPGLGLLLIEAILGYD 148

                         170       180       190
                  ....*....|....*....|....*....|...
gi 446194974  192 GTQ-VEMILFAGFVYFVISLSASLLVSYLKRRT 223
Cdd:pfam00528 149 YPEiQGPVLAAALILLLLNLLVDILQRLLDPRV 181
PRK10782 PRK10782
D-methionine ABC transporter permease MetI;
20-155 1.15e-05

D-methionine ABC transporter permease MetI;


Pssm-ID: 182726  Cd Length: 217  Bit Score: 44.72  E-value: 1.15e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  20 LVITLKITVTAVVIGILWGTMLAVMR---LSSFAPVSWFAKAYVNVFRSIPLVMVLLWfylIVPgFLQNVLGLSpkndIR 96
Cdd:PRK10782  17 LAMTFVSGFFGFVIGLPVGVLLYVTRpgqIIANAKLYRTLSALVNIFRSIPFIILLVW---MIP-FTRVIVGTS----IG 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446194974  97 LISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMV 155
Cdd:PRK10782  89 LQAAIVPLTVGAAPFIARMVENALLEIPTGLIEASRAMGATPMQIVRKVLLPEALPGLV 147
phosphate_pstC TIGR02138
phosphate ABC transporter, permease protein PstC; The typical operon for the high affinity ...
 15-222 2.19e-05

phosphate ABC transporter, permease protein PstC; The typical operon for the high affinity inorganic phosphate ABC transporter encodes an ATP-binding protein, a phosphate-binding protein, and two permease proteins. This family consists of one of the two permease proteins, PstC, which is homologous to PstA (TIGR00974). In the model bacterium Escherichia coli, this transport system is induced when the concentration of extrallular inorganic phosphate is low. A constitutive, lower affinity transporter operates otherwise. [Transport and binding proteins, Anions]


Pssm-ID: 273992 [Multi-domain]  Cd Length: 295  Bit Score: 44.18  E-value: 2.19e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   15 YLLDGLVITLKITVTAVVIGILWGTMLAVMrLSSFAP--VSWFAKAYVNVFRSIPLVMVLLW--------FYLIVPGFLQ 84
Cdd:TIGR02138  60 GALPLIVGTLITSLIALLIAVPVGIGIAIF-LSEIAPkrVRSVLKPVVELLAGIPSVVYGFWglfvlvpfLKPHFQPFLG 138

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   85 NVLGLSPKNDIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMV-PLLLTQG- 162
Cdd:TIGR02138 139 SNLGLIPLFGGPILTAGIVLAIMILPTIASISRDALRAVPRSYKEASYALGATKWETIRRVILPAARSGIVgAVVLGLGr 218

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446194974  163 ------IVLFQdTSLVYVLSLADFFRTASTI--------GERDGTQVEM-ILFA-GFVYFVISLSASLLVSYLKRR 222
Cdd:TIGR02138 219 algetmAVTMV-IGNVFPISPLSLFDPGTTItslianqfGEASGGSVHTsALFAlGLVLFVITLLVNILARYIVRR 293
PstC COG0573
ABC-type phosphate transport system, permease component [Inorganic ion transport and ...
 20-222 1.12e-04

ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440338 [Multi-domain]  Cd Length: 303  Bit Score: 42.00  E-value: 1.12e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  20 LVITLKITVTAVVIGILWGTMLAVMrLSSFAP--VSWFAKAYVNVFRSIPLVMVLLWFYLIVPGFLQNVLGLSPkndirl 97
Cdd:COG0573   79 IVGTLLVSLIALLIAVPLGLGIAIF-LSEYAPprLRRILKPAIELLAGIPSVVYGFWGLFVLVPLLRDLFPWPP------ 151

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  98 isamVAFSMFEAA---------YYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAF------------RA--- 153
Cdd:COG0573  152 ----SGFSLLTAGivlaimilpTITSLSRDALRAVPRSLREAALALGATRWETIRKVVLPAARsgiiaavilglgRAlge 227

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446194974 154 -MVPLLLTQGIVLFQdtslvyvLSLADFFRT-----ASTIGE--RDGTQVEMILFAGFVYFVISLSASLLVSYLKRR 222
Cdd:COG0573  228 tMAVLMVAGNAPQIP-------FSLFDPGRTltaliALEFGEapFGSLHYSALFALGLVLFVITLLVNLLARLIVRR 297
MetP COG2011
ABC-type methionine transport system, permease component [Amino acid transport and metabolism]; ...
 2-155 4.23e-04

ABC-type methionine transport system, permease component [Amino acid transport and metabolism];


Pssm-ID: 441614  Cd Length: 220  Bit Score: 40.04  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974   2 YEFDWSSIVPSL-PYLLDGLVITLKITVTAVVIGILWGTMLAVMRLSSFAPVSWFAK---AYVNVFRSIPLVMVLLWfyl 77
Cdd:COG2011    1 MLTMWSELWPLLlQATGETLYMVGVSTLIAVLLGLPLGVLLVLTRPGGLLPNPVLYRvlgVIVNIFRSIPFIILLVA--- 77

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446194974  78 IVPgFLQNVLGLSpkndIRLISAMVAFSMFEAAYYSEIIRAGIQSISLGQSSAALALGMTHWQSMKLIILPQAFRAMV 155
Cdd:COG2011   78 LIP-LTRLIVGTS----IGTTAAIVPLTIAAIPFFARLVENALREVDPGVIEAAQAMGASPWQIIFKVLLPEALPSLI 150
TauC COG0600
ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion ...
 14-150 1.83e-03

ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440365 [Multi-domain]  Cd Length: 254  Bit Score: 38.21  E-value: 1.83e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446194974  14 PYLLDGLVITLKITVTAVVIGILWGTMLAVMrLSSFAPVSWFAKAYVNVFRSIPLVMVLLWFYLIVPgflqnvLGLSPKn 93
Cdd:COG0600   57 GELWEHLLASLLRVLLGFALAALLGVPLGLL-LGLSRLLRRLLDPLLVFLRPIPPLALAPLLILWFG------IGEASK- 128

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 446194974  94 dIRLISAMVAFSMFEAAYyseiirAGIQSISLGQSSAALALGMTHWQSMKLIILPQA 150
Cdd:COG0600  129 -IFVIFLGAFFPILLNTA------AGVRSVDPELLELARSLGASRWQILRKVVLPAA 178
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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