|
Name |
Accession |
Description |
Interval |
E-value |
| PRK09835 |
PRK09835 |
Cu(+)/Ag(+) sensor histidine kinase; |
1-479 |
0e+00 |
|
Cu(+)/Ag(+) sensor histidine kinase;
Pssm-ID: 182101 [Multi-domain] Cd Length: 482 Bit Score: 892.59 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 1 MVSKPFQRPFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIV 80
Cdd:PRK09835 1 MVSKPFQRPFSLATRLTFFISLATIAAFFAFTWIMIHSVKVHFAEQDINDLKQISATLERVLNHPDETQARRLMTLEDIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 81 SGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDARGGEVYLLSGPTIMMPGHGHGHMEHSNWRMINLPVGPLVD 160
Cdd:PRK09835 81 AGYSNVLISLADSHGKTVYHSPGAPDLREFVRDAIPDKDARGGEVFLWSGPTPMMPGHGHGHMEHSNWRMIALPVGPLVD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 161 GKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIE 240
Cdd:PRK09835 161 GKPIYTLLIALSIDFHLHYINDLKNKLIMTASVISLLIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIE 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 241 LEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLF 320
Cdd:PRK09835 241 LEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLF 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 321 LAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVR 400
Cdd:PRK09835 321 LAQADNNQLIPEKKMLDLADEVGKVFDFFEAWAEERGVELRFVGDPCQVAGDPLMLRRAISNLLSNALRYTPAGEAITVR 400
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446175987 401 CQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLP 479
Cdd:PRK09835 401 CQEVDHQVQLVVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVISLP 479
|
|
| cztS_silS_copS |
TIGR01386 |
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain ... |
9-479 |
1.46e-168 |
|
heavy metal sensor kinase; Members of this family contain a sensor histidine kinase domain (pfam00512) and a domain found in bacterial signal proteins (pfam00672). This group is separated phylogenetically from related proteins with similar architecture and contains a number of proteins associated with heavy metal resistance efflux systems for copper, silver, cadmium, and/or zinc.
Pssm-ID: 273593 [Multi-domain] Cd Length: 457 Bit Score: 482.66 E-value: 1.46e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 9 PFSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHP---DETQARRLMTLEDIVSGYSN 85
Cdd:TIGR01386 1 PRSLTLRLALLFAAVTALVFALSGFMLYSSLERHFEERDREELQGKLEQVRRFLRDPadlDEDIKRLQEKIDDLLVGHSD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 86 VLISLADSQGKTVYHSPGAPDIREftrdAIPDKDARGGEVYLLSGptimmpghghghMEHSNWRMINLPVGPLVDGKPIY 165
Cdd:TIGR01386 81 LALSILNPDGRLLFERAQGAALVP----AVAANDALLELDQADAK------------MTHYRSILRSVAALPGGKGRKPV 144
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 166 TLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLV 245
Cdd:TIGR01386 145 QITVALDINAHTHLLDALRKWLILIAVLLVLLTALLGWWITRLGLEPLRRLSAVAARISPESLDQRLDPSRAPAELRELA 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 246 LSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQAD 325
Cdd:TIGR01386 225 QSFNAMLGRLEDAFQRLSQFSADLAHELRTPLTNLLGQTQVALSQPRTGEEYREVLESNLEELERLSRMVSDMLFLARAD 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 326 NNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDkCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVD 405
Cdd:TIGR01386 305 NGQLALERVRLDLAAELAKVAEYFEPLAEERGVRIRVEGE-GLVRGDPQMFRRAISNLLSNALRHTPDGGTITVRIERRS 383
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446175987 406 HLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLP 479
Cdd:TIGR01386 384 DEVRVSVSNPGPGIPPEHLSRLFDRFYRVDPARSNSGEGTGLGLAIVRSIMEAHGGRASAESPDGKTRFILRFP 457
|
|
| WalK |
COG5002 |
Sensor histidine kinase WalK [Signal transduction mechanisms]; |
167-480 |
1.02e-74 |
|
Sensor histidine kinase WalK [Signal transduction mechanisms];
Pssm-ID: 444026 [Multi-domain] Cd Length: 390 Bit Score: 240.22 E-value: 1.02e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 167 LYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQLVL 246
Cdd:COG5002 70 LLLLLLLLLLALALLLLALLLLLLLLLLLLALLILLLLLALLILLAALLLLLSELLLLLLLLGRLSLRLSALLLGLLLLA 149
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 247 SFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKE-LEDVLYSNLEELTRMAKMVSDMLFLAQAD 325
Cdd:COG5002 150 AVERDITELERLEQMRREFVANVSHELRTPLTSIRGYLELLLDGAADDPEeRREYLEIILEEAERLSRLVNDLLDLSRLE 229
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 326 NNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRF--VGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQT 403
Cdd:COG5002 230 SGELKLEKEPVDLAELLEEVVEELRPLAEEKGIELELdlPEDPLLVLGDPDRLEQVLTNLLDNAIKYTPEGGTITVSLRE 309
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446175987 404 VDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG5002 310 EDDQVRISVRDTGIGIPEEDLPRIFERFYRVDKSRSRETGGTGLGLAIVKHIVEAHGGRIWVESEPgKGTTFTITLPL 387
|
|
| BaeS |
COG0642 |
Signal transduction histidine kinase [Signal transduction mechanisms]; |
164-480 |
9.01e-68 |
|
Signal transduction histidine kinase [Signal transduction mechanisms];
Pssm-ID: 440407 [Multi-domain] Cd Length: 328 Bit Score: 220.16 E-value: 9.01e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 164 IYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPIELEQ 243
Cdd:COG0642 12 LLLLLLLLLALLLLLLLLLLLALLLLLALLLLLLLLLLLLLLLALALLALLLLLLLLLLLLLLLLLLLLLLLLLLLLLLL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 244 LVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSqkELEDVLYSNLEELTRMAKMVSDMLFLAQ 323
Cdd:COG0642 92 LLLLLLALLLLLEEANEAKSRFLANVSHELRTPLTAIRGYLELLLEELDE--EQREYLETILRSADRLLRLINDLLDLSR 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 324 ADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFV--GDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRC 401
Cdd:COG0642 170 LEAGKLELEPEPVDLAELLEEVVELFRPLAEEKGIELELDlpDDLPTVRGDPDRLRQVLLNLLSNAIKYTPEGGTVTVSV 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 402 QTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSrqRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG0642 250 RREGDRVRISVEDTGPGIPPEDLERIFEPFFRTDPS--RRGGGTGLGLAIVKRIVELHGGTIEVESEPgKGTTFTVTLPL 327
|
|
| KdpD |
COG2205 |
K+-sensing histidine kinase KdpD [Signal transduction mechanisms]; |
249-480 |
5.60e-62 |
|
K+-sensing histidine kinase KdpD [Signal transduction mechanisms];
Pssm-ID: 441807 [Multi-domain] Cd Length: 239 Bit Score: 202.06 E-value: 5.60e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 249 NHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQ-SRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNN 327
Cdd:COG2205 3 EEALEELEELERLKSEFLANVSHELRTPLTSILGAAELLLDEeDLSPEERRELLEIIRESAERLLRLIEDLLDLSRLESG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 328 QLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFV--GDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVD 405
Cdd:COG2205 83 KLSLELEPVDLAELLEEAVEELRPLAEEKGIRLELDlpPELPLVYADPELLEQVLANLLDNAIKYSPPGGTITISARREG 162
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175987 406 HLVQVIVENPGTPIAPEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG2205 163 DGVRISVSDNGPGIPEEELERIFERFYRGD--NSRGEGGTGLGLAIVKRIVEAHGGTIWVESEPgGGTTFTVTLPL 236
|
|
| AdeS_HK |
NF012226 |
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component ... |
188-480 |
1.79e-38 |
|
two-component sensor histidine kinase AdeS; Mutations in this component of the two-component regulatory system for the AdeABC efflux pump can confer adaptive resistance to certain antibiotics, including tigecycline.
Pssm-ID: 411090 [Multi-domain] Cd Length: 353 Bit Score: 143.21 E-value: 1.79e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 188 IMTASVISILIV------FIVllavhkghaPIRSVSRQIQNITSKDLDVRLDPQTV-PIELEQLVLSFNHMIERIEDVFT 260
Cdd:NF012226 66 ILCGSVISLIIGmklaqrFIV---------PINFLADAAKKISQGDLSARAEDSQIhSAEISELMHNFNDMAQKLESSVK 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 261 RQSNFSADIAHEIRTPITNLitqteialsQSRSQKELEDV----------LYSNLEELTRmakMVSDMLFLAQADNNQLI 330
Cdd:NF012226 137 NAQVWNAAIAHELRTPITIL---------QGRLQGILDGVfepdpalfksLLNQVEGLSH---LVEDLRTLSLVENQQLR 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 331 PEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQV 410
Cdd:NF012226 205 LNYESVDLKDSIEKVLKMFEDRLEQAQLTIVLNLTATPVFCDRRRIEQVLIALIDNAIRYANAGKLKISSSVIQDDWILQ 284
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446175987 411 IV-ENPGtpIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLPA 480
Cdd:NF012226 285 IEdEGPG--IAEEYQQDLFNPFFRLEQSRNKEFGGTGLGLAVVHAIVIAHKGSIEYSNSQGNSVFTIKLPA 353
|
|
| phoR |
PRK11006 |
phosphate regulon sensor histidine kinase PhoR; |
264-480 |
1.46e-37 |
|
phosphate regulon sensor histidine kinase PhoR;
Pssm-ID: 182895 [Multi-domain] Cd Length: 430 Bit Score: 142.46 E-value: 1.46e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 264 NFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFL------AQADNNQLIPEKKMLN 337
Cdd:PRK11006 206 NFFANVSHELRTPLTVLQGYLEMMQDQPLEGALREKALHTMREQTQRMEGLVKQLLTLskieaaPTIDLNEKVDVPMMLR 285
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 338 -LADEVgkvfdffEALAEDRGvELRF-VGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENP 415
Cdd:PRK11006 286 vLEREA-------QTLSQGKH-TITFeVDNSLKVFGNEDQLRSAISNLVYNAVNHTPEGTHITVRWQRVPQGAEFSVEDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175987 416 GTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLPA 480
Cdd:PRK11006 358 GPGIAPEHIPRLTERFYRVDKARSRQTGGSGLGLAIVKHALSHHDSRLEIESEvGKGTRFSFVLPE 423
|
|
| COG4191 |
COG4191 |
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal ... |
266-480 |
6.36e-36 |
|
Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms];
Pssm-ID: 443345 [Multi-domain] Cd Length: 361 Bit Score: 136.47 E-value: 6.36e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 266 SADIAHEIRTPITNLITQTEIA---LSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNnqliPEKKMLNLADEV 342
Cdd:COG4191 146 AAGIAHEINNPLAAILGNAELLrrrLEDEPDPEELREALERILEGAERAAEIVRSLRAFSRRDE----EEREPVDLNELI 221
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 343 GKVFDFFEALAEDRGVELRFVGDK--CQVAGDPLMLRRALSNLLSNALRYTPTGE--TIVVRCQTVDHLVQVIVENPGTP 418
Cdd:COG4191 222 DEALELLRPRLKARGIEVELDLPPdlPPVLGDPGQLEQVLLNLLINAIDAMEEGEggRITISTRREGDYVVISVRDNGPG 301
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175987 419 IAPEHLPRLFDRFYrvdpSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG4191 302 IPPEVLERIFEPFF----TTKPVGKGTGLGLSISYGIVEKHGGRIEVESEPgGGTTFTITLPL 360
|
|
| NtrY |
COG5000 |
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism ... |
269-480 |
2.55e-35 |
|
Signal transduction histidine kinase NtrY involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms];
Pssm-ID: 444024 [Multi-domain] Cd Length: 422 Bit Score: 136.25 E-value: 2.55e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 269 IAHEIRTPITNlitqteIALSQSRSQKELEDVLYSNLEELT-----------RMAKMVSDMLFLAQADNnqliPEKKMLN 337
Cdd:COG5000 208 IAHEIKNPLTP------IQLSAERLRRKLADKLEEDREDLEraldtiirqvdRLKRIVDEFLDFARLPE----PQLEPVD 277
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 338 LADEVGKVFDFFEALAEDRGVELRF--VGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENP 415
Cdd:COG5000 278 LNELLREVLALYEPALKEKDIRLELdlDPDLPEVLADRDQLEQVLINLLKNAIEAIEEGGEIEVSTRREDGRVRIEVSDN 357
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175987 416 GTPIAPEHLPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG5000 358 GPGIPEEVLERIFEPFF------TTKPKGTGLGLAIVKKIVEEHGGTIELESRPgGGTTFTIRLPL 417
|
|
| PRK11100 |
PRK11100 |
sensory histidine kinase CreC; Provisional |
188-480 |
1.00e-34 |
|
sensory histidine kinase CreC; Provisional
Pssm-ID: 236846 [Multi-domain] Cd Length: 475 Bit Score: 135.36 E-value: 1.00e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 188 IMTASVISILIVFIVLLAVHKG-HAPIRSVSRQIQNITskdldvrlDPQTVPI------ELEQLVLSFNHMIERIEDvft 260
Cdd:PRK11100 184 ILWAGALLLGIALLIGAGVVWWlNRSIRRLTRYADAVT--------EGKPVPLpklgssELRELAQALESMRVKLEG--- 252
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 261 RQ--SNFSADIAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNL 338
Cdd:PRK11100 253 KAyvEQYVQTLTHELKSPLAAIRGAAEL-LQEDPPPEDRARFTGNILTQSARLQQLIDRLLELARLEQRQELEVLEPVAL 331
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 339 ADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTP 418
Cdd:PRK11100 332 AALLEELVEAREAQAAAKGITLRLRPDDARVLGDPFLLRQALGNLLDNAIDFSPEGGTITLSAEVDGEQVALSVEDQGPG 411
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175987 419 IaPEH-LPRLFDRFY---RvdPSRQRKgeGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVITLPA 480
Cdd:PRK11100 412 I-PDYaLPRIFERFYslpR--PANGRK--STGLGLAFVREVARLHGGEVTLRNrPEGGVLATLTLPR 473
|
|
| COG4251 |
COG4251 |
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal ... |
147-480 |
2.73e-34 |
|
Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms];
Pssm-ID: 443393 [Multi-domain] Cd Length: 503 Bit Score: 134.53 E-value: 2.73e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 147 NWRMINLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSK 226
Cdd:COG4251 160 LLLLLALILALLLAALAELELLLLLLLVLLLLLLLLLLLLLLLLRLLLELLLLLEAELLLSLGGGLGLLLLLLLLLVLLL 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 227 DLDVRLDPQTVPIELEQLVLSFNHMIERIEDVFT--RQSN-----FSADIAHEIRTPITNLITQTEIAlsqsrsQKELED 299
Cdd:COG4251 240 LLILLLLLLILVLELLELRLELEELEEELEERTAelERSNeeleqFAYVASHDLREPLRKISGFSQLL------EEDYGD 313
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 300 VLYSNLEEL--------TRMAKMVSDMLFLAQADNNQLIPEKkmLNLADEVGKVFDFFEALAEDRGVELRfVGDKCQVAG 371
Cdd:COG4251 314 KLDEEGREYlerirdaaERMQALIDDLLAYSRVGRQELEFEP--VDLNELLEEVLEDLEPRIEERGAEIE-VGPLPTVRG 390
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNALRYTPTGET--IVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRkgEGSGIGL 449
Cdd:COG4251 391 DPTLLRQVFQNLISNAIKYSRPGEPprIEIGAEREGGEWVFSVRDNGIGIDPEYAEKIFEIFQRLHSRDEY--EGTGIGL 468
|
330 340 350
....*....|....*....|....*....|..
gi 446175987 450 AIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG4251 469 AIVKKIVERHGGRIWVESEPgEGATFYFTLPK 500
|
|
| PRK10337 |
PRK10337 |
sensor protein QseC; Provisional |
179-478 |
1.93e-33 |
|
sensor protein QseC; Provisional
Pssm-ID: 182388 [Multi-domain] Cd Length: 449 Bit Score: 131.31 E-value: 1.93e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 179 YINDlMNKLIMTASVISILI-----VFIVLLAVHKGHAPIRSVSRQIQnITSKDLDVRLDPQTVPIELEQLVLSFNHMIE 253
Cdd:PRK10337 151 YRED-MALAIVAGQLIPWLValpimLIILMVLLGRELAPLKKLALALR-MRDPDSETPLNATGVPSEVRPLVEALNQLFA 228
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 254 RIEDVFTRQSNFSADIAHEIRTPITNLITQTEIA-LS----QSRsQKELedvlySNLEE-LTRMAKMVSDMLFL------ 321
Cdd:PRK10337 229 RTHAMMVRERRFTSDAAHELRSPLAALKVQTEVAqLSdddpQAR-KKAL-----LQLHAgIDRATRLVDQLLTLsrldsl 302
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 322 AQADNNQLIPEKKMLNLAdevgkVFDFFEAlAEDRGVELRFVGDKCQV--AGDPLMLRRALSNLLSNALRYTPTGETIVV 399
Cdd:PRK10337 303 DNLQDVAEIPLEDLLQSA-----VMDIYHT-AQQAGIDVRLTLNAHPVirTGQPLLLSLLVRNLLDNAIRYSPQGSVVDV 376
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446175987 400 RCQTvdHLVQVIVENPGtpIAPEHLPRLFDRFYRvdPSRQRKgEGSGIGLAIVKSIVVAHKGTVAVTsDARGTRFVITL 478
Cdd:PRK10337 377 TLNA--RNFTVRDNGPG--VTPEALARIGERFYR--PPGQEA-TGSGLGLSIVRRIAKLHGMNVSFG-NAPEGGFEAKV 447
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
371-479 |
2.31e-33 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 121.99 E-value: 2.31e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 371 GDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPsRQRKGEGSGIGLA 450
Cdd:smart00387 1 GDPDRLRQVLSNLLDNAIKYTPEGGRITVTLERDGDHVEITVEDNGPGIPPEDLEKIFEPFFRTDK-RSRKIGGTGLGLS 79
|
90 100 110
....*....|....*....|....*....|
gi 446175987 451 IVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:smart00387 80 IVKKLVELHGGEISVESEpGGGTTFTITLP 109
|
|
| PRK10604 |
PRK10604 |
sensor protein RstB; Provisional |
221-479 |
1.36e-32 |
|
sensor protein RstB; Provisional
Pssm-ID: 236724 [Multi-domain] Cd Length: 433 Bit Score: 128.57 E-value: 1.36e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 221 QNITSKDLDVR--LDPQTvpiELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitQTEIALSQSRSQKELE 298
Cdd:PRK10604 172 QRLGDGHLAERihFDEGS---SLERLGVAFNQMADNINALIASKKQLIDGIAHELRTPLVRL--RYRLEMSDNLSAAESQ 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 299 dvlysNLE-ELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLR 377
Cdd:PRK10604 247 -----ALNrDIGQLEALIEELLTYARLDRPQNELHLSEPDLPAWLSTHLADIQAVTPEKTVRLDTPHQGDYGALDMRLME 321
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 378 RALSNLLSNALRYTptGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVV 457
Cdd:PRK10604 322 RVLDNLLNNALRYA--HSRVRVSLLLDGNQACLIVEDDGPGIPPEERERVFEPFVRLDPSRDRATGGCGLGLAIVHSIAL 399
|
250 260
....*....|....*....|...
gi 446175987 458 AHKGTVAV-TSDARGTRFVITLP 479
Cdd:PRK10604 400 AMGGSVNCdESELGGARFSFSWP 422
|
|
| cpxA |
PRK09470 |
envelope stress sensor histidine kinase CpxA; |
155-479 |
3.33e-32 |
|
envelope stress sensor histidine kinase CpxA;
Pssm-ID: 236532 [Multi-domain] Cd Length: 461 Bit Score: 128.13 E-value: 3.33e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 155 VGPL--VDGKPIYTLYIALSIDF-HLHYINDLMNK-LIMTASVISILIVFIVLLAVHKGHaPIRSVSRQIQNITSKDLDV 230
Cdd:PRK09470 133 VGPFsvRDGEDNYQLYLIRPANSpQSDFINLLFDRpLLLLLVTMLVSTPLLLWLAWSLAK-PARKLKNAADEVAQGNLRQ 211
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 231 RLDPQTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLitQTEIALSQSRS--QKELEdvlysNLE-E 307
Cdd:PRK09470 212 HPELETGPQEFRQAGASFNQMVTALERMMTSQQRLLSDISHELRTPLTRL--QLATALLRRRQgeSKELE-----RIEtE 284
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 308 LTRMAKMVSDMLFLA-QADNNQLIPEKKMLN-LADEVGKvfDF-FEAlaEDRGVELRFVGD--KCQVAGDPLMLRRALSN 382
Cdd:PRK09470 285 AQRLDSMINDLLVLSrNQQKNHLERETFKANsLWSEVLE--DAkFEA--EQMGKSLTVSAPpgPWPINGNPNALASALEN 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 383 LLSNALRYTPTgeTIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGT 462
Cdd:PRK09470 361 IVRNALRYSHT--KIEVAFSVDKDGLTITVDDDGPGVPEEEREQIFRPFYRVDEARDRESGGTGLGLAIVENAIQQHRGW 438
|
330
....*....|....*...
gi 446175987 463 V-AVTSDARGTRFVITLP 479
Cdd:PRK09470 439 VkAEDSPLGGLRLTIWLP 456
|
|
| HATPase_BaeS-like |
cd16946 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-479 |
1.99e-30 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BaeS HK of the BaeS/BaeR two-component regulatory system (TCS), which responds to envelope stress. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensory domain.
Pssm-ID: 340422 [Multi-domain] Cd Length: 109 Bit Score: 114.10 E-value: 1.99e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAI 451
Cdd:cd16946 1 DRDRLQQLFVNLLENSLRYTDTGGKLRIRAAQTPQEVRLDVEDSAPGVSDDQLARLFERFYRVESSRNRASGGSGLGLAI 80
|
90 100
....*....|....*....|....*....
gi 446175987 452 VKSIVVAHKGTV-AVTSDARGTRFVITLP 479
Cdd:cd16946 81 CHNIALAHGGTIsAEHSPLGGLRLVLTLP 109
|
|
| HATPase_EcPhoR-like |
cd16952 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
4.62e-29 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoR; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli or Vibrio cholera PhoR, the histidine kinase (HK) of PhoB-PhoR a two-component signal transduction system (TCS) involved in phosphate regulation. PhoR monitors extracellular inorganic phosphate (Pi) availability and PhoB, the response regulator, regulates transcription of genes of the phosphate regulon. PhoR is a bifunctional histidine autokinase/phospho-PhoB phosphatase; in phosphate deficiency, it autophosphorylates and Pi is transferred to PhoB, and when environmental Pi is abundant, it removes the phosphoryl group from phosphorylated PhoB. Other roles of PhoB-PhoR TCS have been described, including motility, biofilm formation, intestinal colonization, and virulence in V. cholera. E.coli PhoR and Bacillus subtilis PhoR (whose HATPase domain belongs to a different family) sense very different signals in each bacterium. In E. coli the PhoR signal comes from phosphate transport mediated by the PstSCAB2 phosphate transporter and the PhoU chaperone-like protein while in B. subtilis, the PhoR activation signal comes from wall teichoic acid (WTA) metabolism.
Pssm-ID: 340428 [Multi-domain] Cd Length: 108 Bit Score: 110.37 E-value: 4.62e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 455
Cdd:cd16952 1 LRSAFSNLVSNAVKYTPPSDTITVRWSQEESGARLSVEDTGPGIPPEHIPRLTERFYRVDIERCRNTGGTGLGLAIVKHV 80
|
90 100
....*....|....*....|....*
gi 446175987 456 VVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:cd16952 81 MSRHDARLLIASElGKGSRFTCLFP 105
|
|
| PRK10549 |
PRK10549 |
two-component system sensor histidine kinase BaeS; |
211-479 |
6.12e-29 |
|
two-component system sensor histidine kinase BaeS;
Pssm-ID: 182539 [Multi-domain] Cd Length: 466 Bit Score: 118.97 E-value: 6.12e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 211 APIRSVSRQIQNITSKDLDVRLDPqTVPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEiALsQ 290
Cdd:PRK10549 190 APVKRLVEGTHKLAAGDFTTRVTP-TSRDELGRLAQDFNQLASTLEKNEQMRRDFMADISHELRTPLAVLRGELE-AI-Q 266
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 291 SRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRF-VGDKCQV 369
Cdd:PRK10549 267 DGVRKFTPESVASLQAEVGTLTKLVDDLHQLSLSDEGALAYRKTPVDLVPLLEVAGGAFRERFASRGLTLQLsLPDSATV 346
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 370 AGDPLMLRRALSNLLSNALRYT-PTGETIVVRCQTVDHLVQVIVEN-PGtpIAPEHLPRLFDRFYRVDPSRQRKGEGSGI 447
Cdd:PRK10549 347 FGDPDRLMQLFNNLLENSLRYTdSGGSLHISAEQRDKTLRLTFADSaPG--VSDEQLQKLFERFYRTEGSRNRASGGSGL 424
|
250 260 270
....*....|....*....|....*....|...
gi 446175987 448 GLAIVKSIVVAHKGTV-AVTSDARGTRFVITLP 479
Cdd:PRK10549 425 GLAICLNIVEAHNGRIiAAHSPFGGVSITVELP 457
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
371-479 |
2.43e-28 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 108.22 E-value: 2.43e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 371 GDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVqVIVENPGTPIAPEHLPRLFDRFYRVDpsrQRKGEGSGIGLA 450
Cdd:pfam02518 1 GDELRLRQVLSNLLDNALKHAAKAGEITVTLSEGGELT-LTVEDNGIGIPPEDLPRIFEPFSTAD---KRGGGGTGLGLS 76
|
90 100 110
....*....|....*....|....*....|
gi 446175987 451 IVKSIVVAHKGTVAVTSDA-RGTRFVITLP 479
Cdd:pfam02518 77 IVRKLVELLGGTITVESEPgGGTTVTLTLP 106
|
|
| NtrB |
COG3852 |
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms]; |
269-480 |
3.36e-26 |
|
Signal transduction histidine kinase NtrB, nitrogen specific [Signal transduction mechanisms];
Pssm-ID: 443061 [Multi-domain] Cd Length: 361 Bit Score: 109.17 E-value: 3.36e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 269 IAHEIRTPITNLITQTEIALSQSRSQKELE--DVLysnLEELTRMAKMVSDMLFLAQadnnQLIPEKKMLNLADEVGKVF 346
Cdd:COG3852 142 LAHEIRNPLTGIRGAAQLLERELPDDELREytQLI---IEEADRLNNLVDRLLSFSR----PRPPEREPVNLHEVLERVL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 347 DFFEALAeDRGVELR--FVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRC----------QTVDHLVQVIVEN 414
Cdd:COG3852 215 ELLRAEA-PKNIRIVrdYDPSLPEVLGDPDQLIQVLLNLVRNAAEAMPEGGTITIRTrverqvtlggLRPRLYVRIEVID 293
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175987 415 PGTPIAPEHLPRLFDRFYRvdpsrqRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:COG3852 294 NGPGIPEEILDRIFEPFFT------TKEKGTGLGLAIVQKIVEQHGGTIEVESEPgKGTTFRIYLPL 354
|
|
| KinE |
COG5809 |
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome ... |
265-479 |
1.31e-25 |
|
Sporulation sensor histidine kinase E [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444511 [Multi-domain] Cd Length: 489 Bit Score: 109.29 E-value: 1.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 265 FSADIAHEIRTPITNLITQTEIaLSQSRSQKELEdvlYSN--LEELTRMAKMVSDMLFLA--QADNNQLIpekkmlNLAD 340
Cdd:COG5809 273 LAAGIAHEIRNPLTSLKGFIQL-LKDTIDEEQKT---YLDimLSELDRIESIISEFLVLAkpQAIKYEPK------DLNT 342
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 341 EVGKVFDFFEALAEDRGV--ELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQ-TVDHLVQVIVENPGT 417
Cdd:COG5809 343 LIEEVIPLLQPQALLKNVqiELELEDDIPDILGDENQLKQVFINLLKNAIEAMPEGGNITIETKaEDDDKVVISVTDEGC 422
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175987 418 PIAPEHLPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:COG5809 423 GIPEERLKKLGEPFY------TTKEKGTGLGLMVSYKIIEEHGGKITVESEvGKGTTFSITLP 479
|
|
| PRK10755 |
PRK10755 |
two-component system sensor histidine kinase PmrB; |
178-480 |
4.10e-25 |
|
two-component system sensor histidine kinase PmrB;
Pssm-ID: 236751 [Multi-domain] Cd Length: 356 Bit Score: 106.21 E-value: 4.10e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 178 HYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDvRLDPQTVPIELEQLVLSFNHMIERIED 257
Cdd:PRK10755 54 KEIREAVASLLVPSLVMVSLTLLICFQAVRWITRPLAELQKELEARTADNLT-PIAIHSSTLEIEAVTSALNQLVSRLTS 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 258 VFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQ-KELedvlysnLEELTRMAKMVSDMLFLAQADNNQLIPEKKML 336
Cdd:PRK10755 133 TLDQERLFTADVAHELRTPLAGIRLHLELLEKQHHIDvAPL-------IARLDQMMHTVEQLLQLARAGQSFSSGHYQTV 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 337 NLADEVGK-VFDFFEALAEDRGVELRFVGDKCQ--VAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVE 413
Cdd:PRK10755 206 KLLEDVILpSQDELSEMLEQRQQTLLLPESAADitVQGDATLLRLLLRNLVENAHRYSPEGSTITIKLSQEDGGAVLAVE 285
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446175987 414 NPGTPIAPEHLPRLFDRFYRVDpsrQRKGeGSGIGLAIVKSIVVAHKGTVAVT--SDARGTRFVITLPA 480
Cdd:PRK10755 286 DEGPGIDESKCGELSKAFVRMD---SRYG-GIGLGLSIVSRITQLHHGQFFLQnrQERSGTRAWVWLPK 350
|
|
| HATPase_EvgS-ArcB-TorS-like |
cd16922 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid ... |
376-479 |
4.52e-25 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases, many are hybrid sensor histidine kinases, similar to Escherichia coli EvgS, ArcB, TorS, BarA, RcsC; This family contains the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinases (HKs), including the following Escherichia coli HKs: EvgS, a HK of the EvgS-EvgA two-component system (TCS) that confers acid resistance; ArcB, a HK of the ArcB-ArcA TCS that modulates the expression of numerous genes in response to respiratory growth conditions; TorS, a HK of the TorS-TorR TCS which is involved in the anaerobic utilization of trimethylamine-N-oxide; BarA, a HK of the BarA-UvrY TCS involved in the regulation of carbon metabolism; and RcsC, a HK of the RcsB-RcsC TCS which regulates the expression of the capsule operon and of the cell division gene ftsZ. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), with most having accessory sensor domain(s) such as GAF, PAS and CHASE; many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340399 [Multi-domain] Cd Length: 110 Bit Score: 99.10 E-value: 4.52e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGEtIVVRCQTVDH-----LVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLA 450
Cdd:cd16922 1 LRQILLNLLGNAIKFTEEGE-VTLRVSLEEEeedgvQLRFSVEDTGIGIPEEQQARLFEPFSQADSSTTRKYGGTGLGLA 79
|
90 100 110
....*....|....*....|....*....|
gi 446175987 451 IVKSIVVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:cd16922 80 ISKKLVELMGGDISVESePGQGSTFTFTLP 109
|
|
| HATPase_BasS-like |
cd16940 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
368-478 |
1.38e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli BasS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) similar to Escherichia coli BasS HK of the BasS-BasR two-component regulatory system (TCS). Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some contain a HAMP sensory domain, while some an N-terminal two-component sensor kinase domain.
Pssm-ID: 340417 [Multi-domain] Cd Length: 113 Bit Score: 97.86 E-value: 1.38e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 368 QVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHlVQVIVENPGTPIAPEHLPRLFDRFYRVDPsrqRKGEGSGI 447
Cdd:cd16940 6 QVQGDALLLFLLLRNLVDNAVRYSPQGSRVEIKLSADDG-AVIRVEDNGPGIDEEELEALFERFYRSDG---QNYGGSGL 81
|
90 100 110
....*....|....*....|....*....|.
gi 446175987 448 GLAIVKSIVVAHKGTVAVtSDARGTRFVITL 478
Cdd:cd16940 82 GLSIVKRIVELHGGQIFL-GNAQGGGLEAWV 111
|
|
| KinC |
COG5807 |
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome ... |
265-479 |
2.49e-24 |
|
Sporulation sensor histidine kinase C [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444509 [Multi-domain] Cd Length: 358 Bit Score: 103.71 E-value: 2.49e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 265 FSADIAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQlipeKKMLNLADEVGK 344
Cdd:COG5807 150 LAAGIAHEIRNPLTSIKGFLQL-LQESREDSEREEYFNIIISEIDRINTIITELLVLSKPKKFN----FKKLNLNDVLED 224
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 345 VFDFFEALAEDRGVELR--FVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPE 422
Cdd:COG5807 225 VIALLSTEAILKNISIKydLADDEPVINGDKNQLKQVFINLIKNAIEAMETGGNITIKTYVEGDFVVISVKDEGIGIPEE 304
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446175987 423 HLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLP 479
Cdd:COG5807 305 VLEKIGEPFFTT------KEEGTGLGLSICKKIIEEHNGTIEVESKPgKGTTFTIYLP 356
|
|
| KinA |
COG5805 |
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle ... |
266-479 |
4.32e-24 |
|
Sporulation sensor histidine kinase A (Stage II sporulation protein SpoIIF/SpoIIJ) [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444507 [Multi-domain] Cd Length: 496 Bit Score: 104.81 E-value: 4.32e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 266 SADIAHEIRTPITNLitQTEIALSQSR--SQKELEDVLysnLEELTRMAKMVSDMLFLAQADNNQlipeKKMLNLADEVG 343
Cdd:COG5805 291 AAGIAHEIRNPLTSI--KGFLQLLQPGieDKEEYFDIM---LSELDRIESIISEFLALAKPQAVN----KEKENINELIQ 361
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 344 KVFDFFEALAEDRGVELRFV--GDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAP 421
Cdd:COG5805 362 DVVTLLETEAILHNIQIRLEllDEDPFIYCDENQIKQVFINLIKNAIEAMPNGGTITIHTEEEDNSVIIRVIDEGIGIPE 441
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*....
gi 446175987 422 EHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLP 479
Cdd:COG5805 442 ERLKKLGEPFFTT------KEKGTGLGLMVSYKIIENHNGTIDIDSKVgKGTTFTITLP 494
|
|
| HATPase_VanS-like |
cd16923 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
8.15e-24 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Enterococcus faecium VanS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Enterococcus faecium VanS HK of the VanS-VanR two-component regulatory system (TCS) which activates the transcription of vanH, vanA and vanX vancomycin resistance genes. It also contains Ecoli YedV and PcoS, probable members of YedW-YedV TCS and PcoS-PcoR TCS, repectively. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); most also have a HAMP sensor domain.
Pssm-ID: 340400 [Multi-domain] Cd Length: 102 Bit Score: 95.53 E-value: 8.15e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSrqRKGEGSGIGLAIVKSI 455
Cdd:cd16923 1 LQRVFSNLLSNAIKYSPENTRIYITSFLTDDVVNIMFKNPSSHPLDFKLEKLFERFYRGDNS--RNTEGAGLGLSIAKAI 78
|
90 100
....*....|....*....|....
gi 446175987 456 VVAHKGTVAVTSDARGTRFVITLP 479
Cdd:cd16923 79 IELHGGSASAEYDDNHDLFKVRLP 102
|
|
| PRK11360 |
PRK11360 |
two-component system sensor histidine kinase AtoS; |
267-479 |
1.80e-23 |
|
two-component system sensor histidine kinase AtoS;
Pssm-ID: 236901 [Multi-domain] Cd Length: 607 Bit Score: 103.51 E-value: 1.80e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 267 ADIAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLA--------QADNNQLIPEkkMLNL 338
Cdd:PRK11360 395 AGVAHEIRNPLTAIRGYVQI-WRQQTSDPPSQEYLSVVLREVDRLNKVIDQLLEFSrpresqwqPVSLNALVEE--VLQL 471
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 339 ADEVGKvfdffealAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRC-QTVDHLVQVIVENPGT 417
Cdd:PRK11360 472 FQTAGV--------QARVDFETELDNELPPIWADPELLKQVLLNILINAVQAISARGKIRIRTwQYSDGQVAVSIEDNGC 543
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175987 418 PIAPEHLPRLFDRFYRVDPSrqrkgeGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:PRK11360 544 GIDPELLKKIFDPFFTTKAK------GTGLGLALSQRIINAHGGDIEVESEpGVGTTFTLYLP 600
|
|
| PRK10364 |
PRK10364 |
two-component system sensor histidine kinase ZraS; |
264-479 |
2.31e-23 |
|
two-component system sensor histidine kinase ZraS;
Pssm-ID: 236674 [Multi-domain] Cd Length: 457 Bit Score: 102.56 E-value: 2.31e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 264 NFSADIAHEIRTPITNL------ITQTEIALSQSRsqkELEDVLYSnleELTRMAKMVSDMLFLAQADNNQLIPekkmLN 337
Cdd:PRK10364 239 HLAAGVAHEIRNPLSSIkglakyFAERAPAGGEAH---QLAQVMAK---EADRLNRVVSELLELVKPTHLALQA----VD 308
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 338 LADEVGKVFDFFEALAEDRGVELRFVGDKC--QVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENP 415
Cdd:PRK10364 309 LNDLINHSLQLVSQDANSREIQLRFTANDTlpEIQADPDRLTQVLLNLYLNAIQAIGQHGVISVTASESGAGVKISVTDS 388
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446175987 416 GTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:PRK10364 389 GKGIAADQLEAIFTPYFTT------KAEGTGLGLAVVHNIVEQHGGTIQVASqEGKGATFTLWLP 447
|
|
| HATPase_CpxA-like |
cd16949 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-480 |
1.48e-22 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CpxA; This family includes the histidine kinase-like ATPase (HATPase) domains of two-component sensor histidine kinase (HKs) similar to Escherichia coli CpxA, HK of the CpxA-CpxR two-component regulatory system (TCS) which may function in acid stress and in cell wall stability. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a CpxA family periplasmic domain.
Pssm-ID: 340425 [Multi-domain] Cd Length: 104 Bit Score: 92.00 E-value: 1.48e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPtgETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 455
Cdd:cd16949 1 LARALENVLRNALRYSP--SKILLDISQDGDQWTITITDDGPGVPEDQLEQIFLPFYRVDSARDRESGGTGLGLAIAERA 78
|
90 100
....*....|....*....|....*.
gi 446175987 456 VVAHKGTV-AVTSDARGTRFVITLPA 480
Cdd:cd16949 79 IEQHGGKIkASNRKPGGLRVRIWLPA 104
|
|
| envZ |
PRK09467 |
osmolarity sensor protein; Provisional |
248-471 |
3.76e-21 |
|
osmolarity sensor protein; Provisional
Pssm-ID: 236531 [Multi-domain] Cd Length: 435 Bit Score: 95.36 E-value: 3.76e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 248 FNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIalsQSRSQKELEDVLYSNLEELTRM-------AKMVSDMLF 320
Cdd:PRK09467 215 FNQMAAGIKQLEDDRTLLMAGVSHDLRTPLTRIRLATEM---MSEEDGYLAESINKDIEECNAIieqfidyLRTGQEMPM 291
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 321 lAQADNNQLIpekkmlnlaDEVgkvfdffeALAE---DRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTpTGEtI 397
Cdd:PRK09467 292 -EMADLNALL---------GEV--------IAAEsgyEREIETALQPGPIEVPMNPIAIKRALANLVVNAARYG-NGW-I 351
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446175987 398 VVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARG 471
Cdd:PRK09467 352 KVSSGTEGKRAWFQVEDDGPGIPPEQLKHLFQPFTRGD--SARGSSGTGLGLAIVKRIVDQHNGKVELGNSEEG 423
|
|
| HATPase_RstB-like |
cd16939 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-480 |
7.87e-21 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Salmonella typhimurium RstB; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Salmonella typhimurium RstB HK of the RstA-RstB two-component regulatory system (TCS), which regulates expression of the constituents participating in pyrimidine metabolism and iron acquisition, and may be required for regulation of Salmonella motility and invasion. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and a HAMP sensor domain.
Pssm-ID: 340416 [Multi-domain] Cd Length: 104 Bit Score: 87.10 E-value: 7.87e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGETIVVRCQtvDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 455
Cdd:cd16939 1 MARALDNLLRNALRYAHRTVRIALLVS--GGRLTLIVEDDGPGIPAAARERVFEPFVRLDPSRDRATGGFGLGLAIVHRV 78
|
90 100
....*....|....*....|....*.
gi 446175987 456 VVAHKGTVAVT-SDARGTRFVITLPA 480
Cdd:cd16939 79 ALWHGGHVECDdSELGGACFRLTWPR 104
|
|
| TMAO_torS |
TIGR02956 |
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the ... |
262-479 |
3.39e-19 |
|
TMAO reductase sytem sensor TorS; This protein, TorS, is part of a regulatory system for the torCAD operon that encodes the pterin molybdenum cofactor-containing enzyme trimethylamine-N-oxide (TMAO) reductase (TorA), a cognate chaperone (TorD), and a penta-haem cytochrome (TorC). TorS works together with the inducer-binding protein TorT and the response regulator TorR. TorS contains histidine kinase ATPase (pfam02518), HAMP (pfam00672), phosphoacceptor (pfam00512), and phosphotransfer (pfam01627) domains and a response regulator receiver domain (pfam00072). [Signal transduction, Two-component systems]
Pssm-ID: 274362 [Multi-domain] Cd Length: 968 Bit Score: 90.99 E-value: 3.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 262 QSNFSADIAHEIRTPITNLI-TQTEIALSQ--SRSQKELEDVLYSNLEELTrmakMVSDMLFLAQADNNQLIPEKKMLNL 338
Cdd:TIGR02956 464 KSAFLATMSHEIRTPLNGILgTLELLGDTGltSQQQQYLQVINRSGESLLD----ILNDILDYSKIEAGHLSISPRPFDL 539
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 339 ADEVGKVFDFFEALAEDRGVELRFVGDKcQV----AGDPLMLRRALSNLLSNALRYTPTGE-TIVVRCQTvDHLVQVIVE 413
Cdd:TIGR02956 540 NALLDDVHHLMVSRAQLKGIQLRLNIPE-QLpnwwQGDGPRIRQVLINLVGNAIKFTDRGSvVLRVSLND-DSSLLFEVE 617
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175987 414 NPGTPIAPEHLPRLFDRFYRVDpSRQRKGeGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:TIGR02956 618 DTGCGIAEEEQATLFDAFTQAD-GRRRSG-GTGLGLAISQRLVEAMDGELGVESElGVGSCFWFTLP 682
|
|
| HATPase_AtoS-like |
cd16943 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
373-479 |
1.49e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 AtoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli AtoS, an HK of the AtoS-AtoC TCS. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have accessory domains such as HAMP or PAS sensor domains or CBS-pair domains.
Pssm-ID: 340419 [Multi-domain] Cd Length: 105 Bit Score: 80.93 E-value: 1.49e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 373 PLMLRRALSNLLSNALRYTPTGETIVVRC-QTVDHlVQVIVENPGTPIAPEHLPRLFDRFYRVDPSrqrkGEGSGIGLAI 451
Cdd:cd16943 1 PSQLNQVLLNLLVNAAQAMEGRGRITIRTwAHVDQ-VLIEVEDTGSGIDPEILGRIFDPFFTTKPV----GEGTGLGLSL 75
|
90 100
....*....|....*....|....*....
gi 446175987 452 VKSIVVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:cd16943 76 SYRIIQKHGGTIRVASvPGGGTRFTIILP 104
|
|
| PRK10490 |
PRK10490 |
sensor protein KdpD; Provisional |
267-479 |
2.22e-18 |
|
sensor protein KdpD; Provisional
Pssm-ID: 236701 [Multi-domain] Cd Length: 895 Bit Score: 88.55 E-value: 2.22e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 267 ADIAHEIRTPITNLITQTEI-----ALSQSRSQKELEDVLysnlEELTRMAKMVSDMLFLA--QADNNQLipEKKMLNLA 339
Cdd:PRK10490 669 AALSHDLRTPLTVLFGQAEIltldlASEGSPHARQASEIR----QQVLNTTRLVNNLLDMAriQSGGFNL--RKEWLTLE 742
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 340 DEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPI 419
Cdd:PRK10490 743 EVVGSALQMLEPGLSGHPINLSLPEPLTLIHVDGPLFERVLINLLENAVKYAGAQAEIGIDAHVEGERLQLDVWDNGPGI 822
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446175987 420 APEHLPRLFDRFYRVDpsRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDAR-GTRFVITLP 479
Cdd:PRK10490 823 PPGQEQLIFDKFARGN--KESAIPGVGLGLAICRAIVEVHGGTIWAENRPEgGACFRVTLP 881
|
|
| HATPase_EnvZ-like |
cd16950 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-471 |
6.59e-18 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli EnvZ and Pseudomonas aeruginosa BfmS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli EnvZ of the EnvZ-OmpR two-component regulatory system (TCS), which functions in osmoregulation. It also contains the HATPase domain of Pseudomonas aeruginosa BfmS, the HK of the BfmSR TCS, which functions in the regulation of the rhl quorum-sensing system and bacterial virulence in P. aeruginosa. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also contain a periplasmic domain.
Pssm-ID: 340426 [Multi-domain] Cd Length: 101 Bit Score: 79.03 E-value: 6.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTptGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSrqRKGEGSGIGLAIVKSI 455
Cdd:cd16950 1 LKRVLSNLVDNALRYG--GGWVEVSSDGEGNRTRIQVLDNGPGIAPEEVDELFQPFYRGDNA--RGTSGTGLGLAIVQRI 76
|
90
....*....|....*.
gi 446175987 456 VVAHKGTVAVTSDARG 471
Cdd:cd16950 77 SDAHGGSLTLANRAGG 92
|
|
| HATPase_TutC-TodS-like |
cd16925 |
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas ... |
372-479 |
1.37e-17 |
|
Histidine kinase-like ATPase domain of hybrid sensor histidine kinases similar to Pseudomonas putida TodS and Thauera aromatica TutC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) such Pseudomonas putida TodS HK of the TodS-TodT two-component regulatory system (TCS) which controls the expression of a toluene degradation pathway. Thauera aromatica TutC may be part of a TCS that is involved in anaerobic toluene metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), PAS sensor domain(s) and a REC domain.
Pssm-ID: 340402 [Multi-domain] Cd Length: 110 Bit Score: 78.30 E-value: 1.37e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNALRYTPTGETIVVRCQTVD-HLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLA 450
Cdd:cd16925 1 DAEKYERVVLNLLSNAFKFTPDGGRIRCILEKFRlNRFLLTVSDSGPGIPPNLREEIFERFRQGDGSSTRAHGGTGLGLS 80
|
90 100 110
....*....|....*....|....*....|.
gi 446175987 451 IVKSIVVAHKGTVAVtSDAR--GTRFVITLP 479
Cdd:cd16925 81 IVKEFVELHGGTVTV-SDAPggGALFQVELP 110
|
|
| PRK09303 |
PRK09303 |
histidine kinase; |
269-479 |
1.97e-17 |
|
histidine kinase;
Pssm-ID: 236462 [Multi-domain] Cd Length: 380 Bit Score: 83.85 E-value: 1.97e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 269 IAHEIRTPIT--NLITQTeIALSQSRSQKELEDVLYSNLEELTR-----MAKMVSDMLFLAQADNNQLIPEKKMLNLADE 341
Cdd:PRK09303 158 LAHDLRTPLTaaSLALET-LELGQIDEDTELKPALIEQLQDQARrqleeIERLITDLLEVGRTRWEALRFNPQKLDLGSL 236
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 342 VGKVFDFFEALAEDRGVELR--FVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVrcqTVDH----LVQVIVENP 415
Cdd:PRK09303 237 CQEVILELEKRWLAKSLEIQtdIPSDLPSVYADQERIRQVLLNLLDNAIKYTPEGGTITL---SMLHrttqKVQVSICDT 313
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446175987 416 GTPIAPEHLPRLFDRFYRVDPSRQRkgEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:PRK09303 314 GPGIPEEEQERIFEDRVRLPRDEGT--EGYGIGLSVCRRIVRVHYGQIWVDSEpGQGSCFHFTLP 376
|
|
| HATPase_FilI-like |
cd16921 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
2.13e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Methanosaeta harundinacea FilI and some hybrid sensor histidine kinases; This family includes FilI, the histidine kinase (HK) component of FilI-FilRs, a two-component signal transduction system (TCS) of the methanogenic archaeon, Methanosaeta harundinacea, which is involved in regulating methanogenesis. The cytoplasmic HK core consists of a C-terminal HK-like ATPase domain (represented here) and a histidine kinase dimerization and phosphoacceptor domain (HisKA) domain, which, in FilI, are coupled to CHASE, HAMP, PAS, and GAF sensor domains. FilI-FilRs catalyzes the phosphotransfer between FilI (HK) and FilRs (FilR1 and FilR2, response regulators) of the TCS. TCSs are predicted to be of bacterial origin, and acquired by archaea by horizontal gene transfer. This model also includes related HATPase domains such as that of Synechocystis sp. PCC6803 phytochrome-like protein Cph1. Proteins having this HATPase domain and HisKA domain also have accessory sensor domains such as CHASE, GAF, HAMP and PAS; some are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340398 [Multi-domain] Cd Length: 105 Bit Score: 77.37 E-value: 2.13e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGET--IVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPsrQRKGEGSGIGLAIVK 453
Cdd:cd16921 1 LGQVLTNLLGNAIKFRRPRRPprIEVGAEDVGEEWTFYVRDNGIGIDPEYAEKVFGIFQRLHS--REEYEGTGVGLAIVR 78
|
90 100
....*....|....*....|....*..
gi 446175987 454 SIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:cd16921 79 KIIERHGGRIWLESEpGEGTTFYFTLP 105
|
|
| HATPase_CreC-like |
cd16945 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-465 |
4.27e-17 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli CreC; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Escherichia coli CreC of the CreC-CreB two-component regulatory system (TCS) involved in catabolic regulation. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), and accessory sensory domain(s) such as HAMP, CACHE or PAS.
Pssm-ID: 340421 [Multi-domain] Cd Length: 106 Bit Score: 76.73 E-value: 4.27e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVD-PSRQRKgeGSGIGLA 450
Cdd:cd16945 1 DPFLLRQAINNLLDNAIDFSPEGGLIALQLEADTEGIELLVFDEGSGIPDYALNRVFERFYSLPrPHSGQK--STGLGLA 78
|
90
....*....|....*
gi 446175987 451 IVKSIVVAHKGTVAV 465
Cdd:cd16945 79 FVQEVAQLHGGRITL 93
|
|
| CitA |
COG3290 |
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction ... |
351-479 |
7.34e-17 |
|
Sensor histidine kinase DipB regulating citrate/malate metabolism [Signal transduction mechanisms];
Pssm-ID: 442519 [Multi-domain] Cd Length: 389 Bit Score: 82.20 E-value: 7.34e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 351 ALAEDRGVELRfVGDKCQVAGDPL---MLRRALSNLLSNALRYTPTGE----TIVVRCQTVDHLVQVIVENPGTPIAPEH 423
Cdd:COG3290 255 ARARERGIDLT-IDIDSDLPDLPLsdtDLVTILGNLLDNAIEAVEKLPeeerRVELSIRDDGDELVIEVEDSGPGIPEEL 333
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446175987 424 LPRLFDRFYrvdPSRqrKGEGSGIGLAIVKSIVVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:COG3290 334 LEKIFERGF---STK--LGEGRGLGLALVKQIVEKYGGTIEVESeEGEGTVFTVRLP 385
|
|
| KinB |
COG5806 |
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome ... |
253-480 |
1.82e-16 |
|
Sporulation sensor histidine kinase B [Cell cycle control, cell division, chromosome partitioning, Signal transduction mechanisms];
Pssm-ID: 444508 [Multi-domain] Cd Length: 412 Bit Score: 81.07 E-value: 1.82e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 253 ERIEDVftrqSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLipE 332
Cdd:COG5806 196 EKLEVV----SELAASIAHEVRNPLTVVRGFIQLLQEPELSDEKRKQYIRIALEELDRAEAIITDYLTFAKPQPEKL--E 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 333 KkmLNLADEVGKVFDFFEALAEDRGVELRF-VGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVI 411
Cdd:COG5806 270 K--IDVSEELEHVIDVLSPYANMNNVEIQTeLEPGLYIEGDRQKLQQCLINIIKNGIEAMPNGGTLTIDVSIDKNKVIIS 347
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 412 VENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLPA 480
Cdd:COG5806 348 IKDTGVGMTKEQLERLGEPYFST------KEKGTGLGTMVSYRIIEAMNGTIRVESEvGKGTTFTITLPL 411
|
|
| PRK11466 |
PRK11466 |
hybrid sensory histidine kinase TorS; Provisional |
240-479 |
1.12e-15 |
|
hybrid sensory histidine kinase TorS; Provisional
Pssm-ID: 236914 [Multi-domain] Cd Length: 914 Bit Score: 79.95 E-value: 1.12e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 240 ELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAkMVSDML 319
Cdd:PRK11466 422 ELQELVIEHRQARAEAEKASQAKSAFLAAMSHEIRTPLYGILGTAQLLADNPALNAQRDDLRAITDSGESLLT-ILNDIL 500
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 320 flaqaDNNQLIPEKKMLNLADEV---GKVFDFFEALAEDR--GVELRFVGDKCQV-----AGDPLMLRRALSNLLSNALR 389
Cdd:PRK11466 501 -----DYSAIEAGGKNVSVSDEPfepRPLLESTLQLMSGRvkGRPIRLATDIADDlptalMGDPRRIRQVITNLLSNALR 575
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 390 YTPTGeTIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDpsrQRKGeGSGIGLAIVKSIVVAHKGTVAVTSD- 468
Cdd:PRK11466 576 FTDEG-SIVLRSRTDGEQWLVEVEDSGCGIDPAKLAEIFQPFVQVS---GKRG-GTGLGLTISSRLAQAMGGELSATSTp 650
|
250
....*....|.
gi 446175987 469 ARGTRFVITLP 479
Cdd:PRK11466 651 EVGSCFCLRLP 661
|
|
| HATPase_BvrS-ChvG-like |
cd16953 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
1.38e-15 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Brucella abortus BvrS and Sinorhizobium meliloti ChvG; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Brucella abortus BvrS of the BvrR-BvrS two-component regulatory system (TCS), which controls cell invasion and intracellular survival, as well as Sinorhizobium meliloti and Agrobacterium tumefaciens ChvG of the ChvI-ChvG TCS necessary for endosymbiosis and pathogenicity in plants. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), an accessory HAMP sensor domain, a periplasmic stimulus-sensing domain, and some also have a sensor N-terminal transmembrane domain.
Pssm-ID: 340429 [Multi-domain] Cd Length: 110 Bit Score: 72.61 E-value: 1.38e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTP--TGETIVVRCQTVDHLVqVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVK 453
Cdd:cd16953 1 LGQVLRNLIGNAISFSPpdTGRITVSAMPTGKMVT-ISVEDEGPGIPQEKLESIFDRFYTERPANEAFGQHSGLGLSISR 79
|
90 100 110
....*....|....*....|....*....|.
gi 446175987 454 SIVVAHKGTVAVT-----SDARGTRFVITLP 479
Cdd:cd16953 80 QIIEAHGGISVAEnhnqpGQVIGARFTVQLP 110
|
|
| PRK15347 |
PRK15347 |
two component system sensor kinase; |
191-479 |
4.93e-15 |
|
two component system sensor kinase;
Pssm-ID: 237951 [Multi-domain] Cd Length: 921 Bit Score: 77.76 E-value: 4.93e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 191 ASVISILIVFIVLLAVHkghapiRSVSRQIQNITS-------KDLDVRLdPQTVPIELEQLVLSFNHMI----------- 252
Cdd:PRK15347 302 ALLILVLLTSVLFLLLR------RYLAKPLWRFVDiinktgpAALEPRL-PENRLDELGSIAKAYNQLLdtlneqydtle 374
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 253 ----ERI----------EDVFTRQSNFSADIAHEIRTPIT------NLITQTEIALSQsrsQKELEDVLYSNLEELTrma 312
Cdd:PRK15347 375 nkvaERTqalaeakqraEQANKRKSEHLTTISHEIRTPLNgvlgalELLQNTPLTAEQ---MDLADTARQCTLSLLA--- 448
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 313 kMVSDMLFLAQADNNQ--LIPEK-KMLNLADEVGKVFdffEALAEDRGVELR-FVGDKC--QVAGDPLMLRRALSNLLSN 386
Cdd:PRK15347 449 -IINNLLDFSRIESGQmtLSLEEtALLPLLDQAMLTI---QGPAQSKSLTLRtFVGAHVplYLHLDSLRLRQILVNLLGN 524
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 387 ALRYTPTGEtIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQrkgeGSGIGLAIVKSIVVAHKGTVAVT 466
Cdd:PRK15347 525 AVKFTETGG-IRLRVKRHEQQLCFTVEDTGCGIDIQQQQQIFTPFYQADTHSQ----GTGLGLTIASSLAKMMGGELTLF 599
|
330
....*....|....
gi 446175987 467 SD-ARGTRFVITLP 479
Cdd:PRK15347 600 STpGVGSCFSLVLP 613
|
|
| PRK09959 |
PRK09959 |
acid-sensing system histidine kinase EvgS; |
262-479 |
5.81e-15 |
|
acid-sensing system histidine kinase EvgS;
Pssm-ID: 182169 [Multi-domain] Cd Length: 1197 Bit Score: 77.85 E-value: 5.81e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 262 QSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVL---YSNLEELTRMAKMVSDMLFLaQADNNQLIPEkkMLNL 338
Cdd:PRK09959 712 KSQFLATMSHEIRTPISSIMGFLELLSGSGLSKEQRVEAIslaYATGQSLLGLIGEILDVDKI-ESGNYQLQPQ--WVDI 788
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 339 ADEVGKVFDFFEALAEDRGVELRFVG---DKCQVAGDPLMLRRALSNLLSNALRYTPTG----ETIVVRCQTVDHLVQVI 411
Cdd:PRK09959 789 PTLVQNTCHSFGAIAASKSIALSCSStfpDHYLVKIDPQAFKQVLSNLLSNALKFTTEGavkiTTSLGHIDDNHAVIKMT 868
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446175987 412 VENPGTPIAPEHLPRLFDRFYRVDPSRQRKgeGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:PRK09959 869 IMDSGSGLSQEEQQQLFKRYSQTSAGRQQT--GSGLGLMICKELIKNMQGDLSLESHpGIGTTFTITIP 935
|
|
| HATPase_BceS-YxdK-YvcQ-like |
cd16948 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
3.59e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis BceS, YxdK, and Bacillus thuringiensis YvcQ; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis BceS and Bacillus thuringiensis YvcQ, the HKs of the two-component regulatory system (TCSs) BceS-BceR and YvcQ-YvcP, repsectively, which are both involved in regulating bacitracin resistance. It also includes the HATPase domain of YxdK, the HK of YxdK-YxdJ TCS involved in sensing antimicrobial compounds.
Pssm-ID: 340424 [Multi-domain] Cd Length: 109 Bit Score: 68.47 E-value: 3.59e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKgEGSGIGLAIVKSI 455
Cdd:cd16948 6 LSFIIGQIVSNALKYSKQGGKIEIYSETNEQGVVLSIKDFGIGIPEEDLPRVFDKGFTGENGRNFQ-ESTGMGLYLVKKL 84
|
90 100
....*....|....*....|....*..
gi 446175987 456 V--VAHKgtVAVTSDAR-GTRFVITLP 479
Cdd:cd16948 85 CdkLGHK--IDVESEVGeGTTFTITFP 109
|
|
| PRK10841 |
PRK10841 |
two-component system sensor histidine kinase RcsC; |
263-479 |
5.57e-14 |
|
two-component system sensor histidine kinase RcsC;
Pssm-ID: 182772 [Multi-domain] Cd Length: 924 Bit Score: 74.62 E-value: 5.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 263 SNFSADIAHEIRTPITNLITQTEiaLSQSRSQKELEDVLysnleeLTRMA-------KMVSDMLFLAQADNNQLIPEKKM 335
Cdd:PRK10841 448 SMFLATVSHELRTPLYGIIGNLD--LLQTKELPKGVDRL------VTAMNnssslllKIISDILDFSKIESEQLKIEPRE 519
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 336 LNLADEVGKVFDFFEALAEDRGVELR-FVGDKCQVA--GDPLMLRRALSNLLSNALRYTPTGeTIVVRCQTVDHLVQVIV 412
Cdd:PRK10841 520 FSPREVINHITANYLPLVVKKRLGLYcFIEPDVPVAlnGDPMRLQQVISNLLSNAIKFTDTG-CIVLHVRVDGDYLSFRV 598
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446175987 413 ENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:PRK10841 599 RDTGVGIPAKEVVRLFDPFFQVGTGVQRNFQGTGLGLAICEKLINMMDGDISVDSEpGMGSQFTIRIP 666
|
|
| HATPase_SpaK_NisK-like |
cd16975 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-476 |
5.73e-14 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Bacillus subtilis SpaK and Lactococcus lactis NisK. SpaK is the histidine kinase (HK) of the SpaK-SpaR two-component regulatory system (TCS), which is involved in the regulation of the biosynthesis of lantibiotic subtilin. NisK is the HK of the NisK-NisR TCS, which is involved in the regulation of the biosynthesis of lantibiotic nisin. SpaK and NisK may function as membrane-associated protein kinases that phosphorylate SpaR and NisR, respectively, in response to environmental signals.
Pssm-ID: 340434 [Multi-domain] Cd Length: 107 Bit Score: 67.87 E-value: 5.73e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEgSGIGLAI 451
Cdd:cd16975 1 DTLLLSRALINIISNACQYAPEGGTVSISIYDEEEYLYFEIWDNGHGFSEQDLKKALELFYRDDTSRRSGGH-YGMGLYI 79
|
90 100
....*....|....*....|....*
gi 446175987 452 VKSIVVAHKGTVAVTSDARGTRFVI 476
Cdd:cd16975 80 AKNLVEKHGGSLIIENSQKGGAEVT 104
|
|
| HATPase_YcbM-like |
cd16947 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-478 |
4.93e-13 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Bacillus subtilis YcbM; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Bacillus subtilis YcbM, a HK of the two-component system YcbM-YcbL. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA).
Pssm-ID: 340423 [Multi-domain] Cd Length: 125 Bit Score: 65.61 E-value: 4.93e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSI 455
Cdd:cd16947 21 LQRILKNLISNAIKYGSDGKFLGMTLREDEKHVYIDIWDKGKGISETEKDHVFERLYTLEDSRNSAKQGNGLGLTITKRL 100
|
90 100
....*....|....*....|....
gi 446175987 456 VVAHKGTVAVTSDA-RGTRFVITL 478
Cdd:cd16947 101 AESMGGSIYVNSKPyEKTVFTVTL 124
|
|
| PRK11091 |
PRK11091 |
aerobic respiration control sensor protein ArcB; Provisional |
265-480 |
6.00e-13 |
|
aerobic respiration control sensor protein ArcB; Provisional
Pssm-ID: 236842 [Multi-domain] Cd Length: 779 Bit Score: 71.13 E-value: 6.00e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 265 FSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTrMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGK 344
Cdd:PRK11091 286 FISTISHELRTPLNGIVGLSRILLDTELTAEQRKYLKTIHVSAIT-LGNIFNDIIDMDKMERRKLQLDNQPIDFTDFLAD 364
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 345 VFDFFEALAEDRGveLRFVGDKCQ-----VAGDPLMLRRALSNLLSNALRYTPTGE-TIVVRCQTVDHLVQViVENPGTP 418
Cdd:PRK11091 365 LENLSGLQAEQKG--LRFDLEPLLplphkVITDGTRLRQILWNLISNAVKFTQQGGvTVRVRYEEGDMLTFE-VEDSGIG 441
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446175987 419 IAPEHLPRLFDRFYRV-DPSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLPA 480
Cdd:PRK11091 442 IPEDELDKIFAMYYQVkDSHGGKPATGTGIGLAVSKRLAQAMGGDITVTSEeGKGSCFTLTIHA 505
|
|
| YesM |
COG2972 |
Sensor histidine kinase YesM [Signal transduction mechanisms]; |
165-479 |
1.31e-12 |
|
Sensor histidine kinase YesM [Signal transduction mechanisms];
Pssm-ID: 442211 [Multi-domain] Cd Length: 445 Bit Score: 69.66 E-value: 1.31e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 165 YTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLdVRLDPQTvPIELEQL 244
Cdd:COG2972 137 WTLVSLIPKSELFRGLFSLRRLILLIILLLLLLALLLSYLLSRSITRPIKRLKKAMKKVEKGDL-VRLEVSG-NDEIGIL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 245 VLSFNHMIERIEDVFTRQsnfsadIAHEIRtpitnlITQTEIALSQSRSQ-----------KELedVLYSNLEELTRMAK 313
Cdd:COG2972 215 ARSFNEMVERIKELIEEV------YELELE------KKEAELKALQAQINphflfntlnsiRWL--AELEDPEEAEEMLE 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 314 MVSDMLFLAQADNNQLIPekkmlnLADEVGKVFDFFEAL---AEDRgveLRFVGDKCQVAGDPLMLRRALSNLLSNALRY 390
Cdd:COG2972 281 ALSKLLRYSLSKGDELVT------LEEELELIKSYLEIQklrFGDR---LEVEIEIDEELLDLLIPKLILQPLVENAIEH 351
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 391 ----TPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFyrvdpsrQRKGEGSGIGLAIVKSIVVAHKGTVAV- 465
Cdd:COG2972 352 giepKEGGGTIRISIRKEGDRLVITVEDNGVGMPEEKLEKLLEEL-------SSKGEGRGIGLRNVRERLKLYYGEEYGl 424
|
330
....*....|....*..
gi 446175987 466 ---TSDARGTRFVITLP 479
Cdd:COG2972 425 eieSEPGEGTTVTIRIP 441
|
|
| PRK10815 |
PRK10815 |
two-component system sensor histidine kinase PhoQ; |
196-471 |
4.01e-12 |
|
two-component system sensor histidine kinase PhoQ;
Pssm-ID: 182754 [Multi-domain] Cd Length: 485 Bit Score: 68.12 E-value: 4.01e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 196 ILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDvRLDPQTvPIELEQLVLSFNHMIERIEDVFTRQSNFSADIAHEIRT 275
Cdd:PRK10815 202 LLVIPLLWLAAWWSLRPIEALAKQVRELEEGERE-QLDPNP-PRELTSLVRNLNRLLKNERERYTKYRTTLTDLTHSLKT 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 276 PITNLitQTeiALSQSRSQKEL--EDVLYSNLEELTRMAKMVSDMLFLA--QADNNQLIPEKKML-----NLADEVGKVF 346
Cdd:PRK10815 280 PLAVL--QS--TLRSLRSGKQMsvEQAEPIMLEQISRISQQIGYYLHRAsmRSEHNLLSRELHSVaplldNLTSALNKVY 355
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 347 dffealaEDRGV--------ELRFVGDK---CQVAGdplmlrralsNLLSNALRYTPtgETIVVRCQTVDHLVQVIVENP 415
Cdd:PRK10815 356 -------QRKGVnitldispEITFVGEKndfMEVMG----------NVLDNACKYCL--EFVEISARQTDEHLHIVVEDD 416
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 446175987 416 GTPIAPEHLPRLFDRFYRVDPSRqrkgEGSGIGLAIVKSIVVAHKGTVAVTSDARG 471
Cdd:PRK10815 417 GPGIPESKRELIFDRGQRADTLR----PGQGLGLSVAREITEQYEGKISAGDSPLG 468
|
|
| PRK13837 |
PRK13837 |
two-component system VirA-like sensor kinase; |
356-479 |
1.25e-11 |
|
two-component system VirA-like sensor kinase;
Pssm-ID: 237526 [Multi-domain] Cd Length: 828 Bit Score: 67.01 E-value: 1.25e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 356 RGVEL--RFVGDKCQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVD---------------HLVQVIVENPGTP 418
Cdd:PRK13837 539 PGVELdfDQDQEPAVVEGNPAELQQVLMNLCSNAAQAMDGAGRVDISLSRAKlrapkvlshgvlppgRYVLLRVSDTGAG 618
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175987 419 IAPEHLPRLFDRFYRVdpsrqRKGeGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:PRK13837 619 IDEAVLPHIFEPFFTT-----RAG-GTGLGLATVHGIVSAHAGYIDVQSTvGRGTRFDVYLP 674
|
|
| HisKA |
cd00082 |
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed ... |
261-323 |
1.84e-11 |
|
Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via trans-autophosphorylation by the catalytic domain of the histidine kinase. They subsequently transfer the phosphoryl group to the Asp acceptor residue of a response regulator protein. Two-component signalling systems, consisting of a histidine protein kinase that senses a signal input and a response regulator that mediates the output, are ancient and evolutionarily conserved signaling mechanisms in prokaryotes and eukaryotes.
Pssm-ID: 119399 [Multi-domain] Cd Length: 65 Bit Score: 59.53 E-value: 1.84e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175987 261 RQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQ 323
Cdd:cd00082 3 AKGEFLANVSHELRTPLTAIRGALELLEEELLDDEEQREYLERIREEAERLLRLINDLLDLSR 65
|
|
| HATPase_TmoS-FixL-DctS-like |
cd16920 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
3.01e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhizobium meliloti FixL, and Rhodobacter capsulatus DctS; includes hybrid sensor histidine kinase similar to Pseudomonas mendocina TmoS; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs), such as Pseudomonas mendocina TmoS HK of the TmoS-TmoT TCS, which controls the expression of the toluene-4-monooxygenase pathway, Rhizobium meliloti FixL HK of the FixL-FixJ TCS, which regulates the expression of the genes related to nitrogen fixation in the root nodule in response to O(2) levels, and Rhodobacter capsulatus DctS of the DctS-DctR TCS, which controls synthesis of the high-affinity C4-dicarboxylate transport system. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and PAS sensor domain(s); many are hybrid sensor histidine kinases as they also contain a REC signal receiver domain.
Pssm-ID: 340397 [Multi-domain] Cd Length: 104 Bit Score: 60.10 E-value: 3.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALR----YTPTGETIVVRCQTVDH-LVQVIVENPGTPIAPEHLPRLFDRFYRVdpsrqrKGEGSGIGLA 450
Cdd:cd16920 1 IQQVLINLVRNGIEamseGGCERRELTIRTSPADDrAVTISVKDTGPGIAEEVAGQLFDPFYTT------KSEGLGMGLS 74
|
90 100 110
....*....|....*....|....*....|
gi 446175987 451 IVKSIVVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:cd16920 75 ICRSIIEAHGGRLSVESpAGGGATFQFTLP 104
|
|
| HATPase_PhoQ-like |
cd16954 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
359-478 |
3.91e-11 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG; This family includes histidine kinase-like ATPase (HATPase) domain of two-component sensor histidine kinases similar to Escherichia coli PhoQ and Providencia stuartii AarG. PhoQ is the histidine kinase (HK) of the PhoP-PhoQ two-component regulatory system (TCS), which responds to the levels of Mg2+ and Ca2+, controls virulence, mediates the adaptation to Mg2+-limiting environments, and regulates numerous cellular activities. Providencia stuartii AarG is a putative sensor kinase which controls the expression of the 2'-N-acetyltransferase and an intrinsic multiple antibiotic resistance (Mar) response in Providencia stuartii. The AarG product is similar to PhoQ in that it is able to restore wild-type levels of resistance to a Salmonella typhimurium phoQ mutant. However, the expression of the 2'-N-acetyltransferase gene and of aarP (a gene encoding a transcriptional activator of 2'-N-acetyltransferase) are not significantly affected by the levels of Mg2+ or Ca2+. Most proteins in this group contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some have an accessory HAMP sensor domain, and some have an intracellular membrane -interaction PhoQ sensor domain.
Pssm-ID: 340430 [Multi-domain] Cd Length: 135 Bit Score: 60.72 E-value: 3.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 359 ELRFVGDKcqvaGDPLMLrraLSNLLSNALRYTptGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSR 438
Cdd:cd16954 28 ELRFPGER----NDLMEL---LGNLLDNACKWC--LEFVEVTARQTDGGLHLIVDDDGPGVPESQRSKIFQRGQRLDEQR 98
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446175987 439 QrkgeGSGIGLAIVKSIVVAHKGTVAVTSDARG-TRFVITL 478
Cdd:cd16954 99 P----GQGLGLAIAKEIVEQYGGELSLSDSPLGgARFEVVF 135
|
|
| HisKA |
pfam00512 |
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine ... |
261-327 |
6.59e-11 |
|
His Kinase A (phospho-acceptor) domain; dimerization and phospho-acceptor domain of histidine kinases.
Pssm-ID: 459839 [Multi-domain] Cd Length: 66 Bit Score: 57.99 E-value: 6.59e-11
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175987 261 RQSNFSADIAHEIRTPITNLITQTEIaLSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNN 327
Cdd:pfam00512 1 AKSEFLANLSHELRTPLTAIRGYLEL-LRDEKLDEEQREYLETILRSAERLLRLINDLLDLSRIEAG 66
|
|
| HisKA |
smart00388 |
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine ... |
261-327 |
5.90e-10 |
|
His Kinase A (phosphoacceptor) domain; Dimerisation and phosphoacceptor domain of histidine kinases.
Pssm-ID: 214644 [Multi-domain] Cd Length: 66 Bit Score: 55.26 E-value: 5.90e-10
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175987 261 RQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKElEDVLYSNLEELTRMAKMVSDMLFLAQADNN 327
Cdd:smart00388 1 AKREFLANLSHELRTPLTAIRGYLELLLDTELSEEQ-REYLETILREAERLLRLINDLLDLSRIEAG 66
|
|
| HATPase_NtrY-like |
cd16944 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
372-479 |
1.01e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Azorhizobium caulinodans NtrY; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Azorhizobium caulinodans ORS571 NtrY of the NtrY-NtrX TCS, which is involved in nitrogen fixation and metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA) and a HAMP sensor domain; some also have PAS sensor domains.
Pssm-ID: 340420 [Multi-domain] Cd Length: 108 Bit Score: 52.92 E-value: 1.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNAL-----RYTPTGE-TIVVRCQTVDHLVqVIVENPGTPIAPEHLPRLFDrfyrvdPSRQRKGEGS 445
Cdd:cd16944 1 DTTQISQVLTNILKNAAeaiegRPSDVGEvRIRVEADQDGRIV-LIVCDNGKGFPREMRHRATE------PYVTTRPKGT 73
|
90 100 110
....*....|....*....|....*....|....*
gi 446175987 446 GIGLAIVKSIVVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:cd16944 74 GLGLAIVKKIMEEHGGRISLSNrEAGGACIRIILP 108
|
|
| HATPase_DpiB-CitA-like |
cd16915 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
380-479 |
1.71e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli K-12 DpiB, DcuS, and Bacillus subtilis CitS, DctS, and YufL; This family includes histidine kinase-like ATPase domains of Escherichia coli K-12 DpiB and DcuS, and Bacillus subtilis CitS, DctS and MalK histidine kinases (HKs) all of which are two component transduction systems (TCSs). E. coli K-12 DpiB (also known as CitA) is the histidine kinase (HK) of DpiA-DpiB, a two-component signal transduction system (TCS) required for the expression of citrate-specific fermentation genes and genes involved in plasmid inheritance. E. coli K-12 DcuS (also known as YjdH) is the HK of DcuS-DcuR, a TCS that in the presence of the extracellular C4-dicarboxlates, activates the expression of the genes of anaerobic fumarate respiration and of aerobic C4-dicarboxylate uptake. CitS is the HK of Bacillus subtilis CitS-CitT, a TCS which regulates expression of CitM, the Mg-citrate transporter. Bacillus subtilis DctS forms a tripartite sensor unit (DctS/DctA/DctB) for sensing C4 dicarboxylates. Bacillus subtilis MalK (also known as YfuL) is the HK of MalK-MalR (YufL-YufM) a TCS which regulates the expression of the malate transporters MaeN (YufR) and YflS, and is essential for utilization of malate in minimal medium. Proteins having this DpiB-CitA-like HATPase domain generally have sensor domains such as Cache and PAS, and a histidine kinase A (HisKA)-like SpoOB-type, alpha-helical domain.
Pssm-ID: 340392 [Multi-domain] Cd Length: 104 Bit Score: 52.29 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 380 LSNLLSNAL----RYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRkgegsGIGLAIVKSI 455
Cdd:cd16915 5 VGNLIDNALdalaATGAPNKQVEVFLRDEGDDLVIEVRDTGPGIAPELRDKVFERGVSTKGQGER-----GIGLALVRQS 79
|
90 100
....*....|....*....|....*
gi 446175987 456 VVAHKGTVAVTS-DARGTRFVITLP 479
Cdd:cd16915 80 VERLGGSITVESePGGGTTFSIRIP 104
|
|
| HATPase_Glnl-NtrB-like |
cd16918 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-479 |
2.00e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli GlnL (synonyms NtrB and NRII); This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs), similar to Escherichia coli GlnL/NtrB/NRII HK of the two-component regulatory system (TCS) GlnL/GlnG (NtrB-NtrC, or NRII-NRI), which regulates the transcription of genes encoding metabolic enzymes and permeases in response to carbon and nitrogen status in E. coli and related bacteria. Also included in this family are Rhodobacter capsulatus NtrB, Azospirillum brasilense NtrB, Vibrio alginolyticus NtrB, Rhizobium leguminosarum biovar phaseoli NtrB, and Herbaspirillum seropedicae NtrB. Escherichia coli GlnL/NtrB/NRII is both a kinase and a phosphatase, catalyzing the phosphorylation and dephosphorylation of GlnG/NtrC/NRI. The kinase and phosphatase activities of GlnL/NtrB/NRII are regulated by the PII signal transduction protein, which on binding to GlnL/NtrB/NRII, inhibits the kinase activity of GlnL/NtrB/NRII and activates the GlnL/NtrB/NRII phosphatase activity. Proteins having this HATPase domain also have a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also contain PAS sensor domain(s).
Pssm-ID: 340395 [Multi-domain] Cd Length: 109 Bit Score: 52.02 E-value: 2.00e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTP-TGETIVVRCQTvDHLV-----------QVIVENPGTPIAPEHLPRLFDrfyrvdPSRQRKGE 443
Cdd:cd16918 1 LIQVFLNLVRNAAQALAgSGGEIILRTRT-QRQVtlghprhrlalRVSVIDNGPGIPPDLQDTIFY------PMVSGREN 73
|
90 100 110
....*....|....*....|....*....|....*.
gi 446175987 444 GSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLP 479
Cdd:cd16918 74 GTGLGLAIAQNIVSQHGGVIECDSQPGHTVFSVSLP 109
|
|
| PRK11107 |
PRK11107 |
hybrid sensory histidine kinase BarA; Provisional |
263-479 |
2.94e-08 |
|
hybrid sensory histidine kinase BarA; Provisional
Pssm-ID: 236848 [Multi-domain] Cd Length: 919 Bit Score: 56.40 E-value: 2.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 263 SNFSADIAHEIRTPI------TNLITQTEIALSQS-------RSQKEL----EDVL-YSNLEEltrmAKMVsdmlflaqa 324
Cdd:PRK11107 294 SEFLANMSHELRTPLngvigfTRQTLKTPLTPTQRdylqtieRSANNLlaiiNDILdFSKLEA----GKLV--------- 360
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 325 dnnqL--IPekkmlnladevgkvFDFFEALAE----------DRGVELRF-----VGDkcQVAGDPLMLRRALSNLLSNA 387
Cdd:PRK11107 361 ----LenIP--------------FSLRETLDEvvtllahsahEKGLELTLnidpdVPD--NVIGDPLRLQQIITNLVGNA 420
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 388 LRYTPTGET-IVVRCQTVDH---LVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTV 463
Cdd:PRK11107 421 IKFTESGNIdILVELRALSNtkvQLEVQIRDTGIGISERQQSQLFQAFRQADASISRRHGGTGLGLVITQKLVNEMGGDI 500
|
250
....*....|....*..
gi 446175987 464 AVTSDA-RGTRFVITLP 479
Cdd:PRK11107 501 SFHSQPnRGSTFWFHLP 517
|
|
| HATPase_HupT_MifS-like |
cd16976 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
376-478 |
3.69e-08 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Rhodobacter capsulatus HupT and Pseudomonas aeruginosa MifS; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component sensor histidine kinase (HKs) such as Rhodobacter capsulatus HupT of the HupT-HupR two-component regulatory system (TCS), which regulates the synthesis of HupSL, a membrane bound [NiFe]hydrogenase. It also contains the HATPase domain of Pseudomonas aeruginosa MifS, the HK of the MifS-MifR TCS, which may be involved in sensing alpha-ketoglutarate and regulating its transport and subsequent metabolism. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA); some also have a C-terminal PAS sensor domain.
Pssm-ID: 340435 [Multi-domain] Cd Length: 102 Bit Score: 51.30 E-value: 3.69e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGET--IVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSrqrkGEGSGIGLAIVK 453
Cdd:cd16976 1 IQQVLMNLLQNALDAMGKVENprIRIAARRLGGRLVLVVRDNGPGIAEEHLSRVFDPFFTTKPV----GKGTGLGLSISY 76
|
90 100
....*....|....*....|....*.
gi 446175987 454 SIVVAHKGTVAVTSDAR-GTRFVITL 478
Cdd:cd16976 77 GIVEEHGGRLSVANEEGaGARFTFDL 102
|
|
| RsbW |
COG2172 |
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; |
337-479 |
4.43e-07 |
|
Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms];
Pssm-ID: 441775 [Multi-domain] Cd Length: 127 Bit Score: 48.76 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 337 NLADEVGKVFDFFEALAEDRGVELRFVGDkcqvagdpLMLrrALSNLLSNALRYT---PTGETIVVRCQTVDHLVQVIVE 413
Cdd:COG2172 6 ADLEDLGLARRAVRALLRELGLDEDDADD--------LVL--AVSEAVTNAVRHAyggDPDGPVEVELELDPDGLEIEVR 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175987 414 NPGTPIAPEHLPrlfdrfyrvDPSRQRKGegSGIGLAIVKSIVvahkGTVAVTSDARGTRFVITLP 479
Cdd:COG2172 76 DEGPGFDPEDLP---------DPYSTLAE--GGRGLFLIRRLM----DEVEYESDPGGTTVRLVKR 126
|
|
| HAMP |
smart00304 |
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; |
211-257 |
5.38e-07 |
|
HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain;
Pssm-ID: 197640 [Multi-domain] Cd Length: 53 Bit Score: 46.47 E-value: 5.38e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 446175987 211 APIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFNHMIERIED 257
Cdd:smart00304 5 RPLRRLAEAAQRIADGDLTVRLPVDGRD-EIGELARAFNEMADRLEE 50
|
|
| HAMP |
pfam00672 |
HAMP domain; |
211-257 |
5.80e-07 |
|
HAMP domain;
Pssm-ID: 459898 [Multi-domain] Cd Length: 53 Bit Score: 46.08 E-value: 5.80e-07
10 20 30 40
....*....|....*....|....*....|....*....|....*..
gi 446175987 211 APIRSVSRQIQNITSKDLDVRLDPQTvPIELEQLVLSFNHMIERIED 257
Cdd:pfam00672 8 RPLRRLAEAARRIASGDLDVRLPVSG-RDEIGELARAFNQMAERLRE 53
|
|
| PRK13557 |
PRK13557 |
histidine kinase; Provisional |
367-480 |
6.18e-07 |
|
histidine kinase; Provisional
Pssm-ID: 237425 [Multi-domain] Cd Length: 540 Bit Score: 51.98 E-value: 6.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 367 CQVagDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVD---------------HLVQVIVENPGTPIAPEHLPRLFDRF 431
Cdd:PRK13557 271 CRI--DPTQAEVALLNVLINARDAMPEGGRVTIRTRNVEiededlamyhglppgRYVSIAVTDTGSGMPPEILARVMDPF 348
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446175987 432 YrvdpSRQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLPA 480
Cdd:PRK13557 349 F----TTKEEGKGTGLGLSMVYGFAKQSGGAVRIYSEVgEGTTVRLYFPA 394
|
|
| HAMP |
cd06225 |
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; ... |
212-255 |
8.79e-07 |
|
Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain; HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices connected by an extended linker. The structure of the Af1503 HAMP dimer from Archaeoglobus fulgidus has been solved using nuclear magnetic resonance, revealing a parallel four-helix bundle; this structure has been confirmed by cross-linking analysis of HAMP domains from the Escherichia coli aerotaxis receptor Aer. It has been suggested that the four-helix arrangement can rotate between the unusually packed conformation observed in the NMR structure and a canonical coiled-coil arrangement. Such rotation may coincide with signal transduction, but a common mechanism by which HAMP domains relay a variety of input signals has yet to be established.
Pssm-ID: 381743 [Multi-domain] Cd Length: 45 Bit Score: 45.51 E-value: 8.79e-07
10 20 30 40
....*....|....*....|....*....|....*....|....
gi 446175987 212 PIRSVSRQIQNITSKDLDVRLDPQTvPIELEQLVLSFNHMIERI 255
Cdd:cd06225 3 PLRRLTEAARRIAEGDLDVRVPVRS-KDEIGELARAFNQMAERL 45
|
|
| ComP |
COG4585 |
Signal transduction histidine kinase ComP [Signal transduction mechanisms]; |
297-479 |
2.90e-06 |
|
Signal transduction histidine kinase ComP [Signal transduction mechanisms];
Pssm-ID: 443642 [Multi-domain] Cd Length: 252 Bit Score: 48.46 E-value: 2.90e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 297 LEDVLYSNLEELTRMAKMVSDMLFLAQADNNQLI-----PEKKMLNLADEVGkvfDFFEALAEDRGVELRFVGDKCQVAG 371
Cdd:COG4585 79 ARRLLDADPEAAREELEEIRELAREALAELRRLVrglrpPALDDLGLAAALE---ELAERLLRAAGIRVELDVDGDPDRL 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DP---LMLRRALSNLLSNALRYTPtGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPrlfdrfyrvdpsrqrkgeGSGIG 448
Cdd:COG4585 156 PPeveLALYRIVQEALTNALKHAG-ATRVTVTLEVDDGELTLTVRDDGVGFDPEAAP------------------GGGLG 216
|
170 180 190
....*....|....*....|....*....|..
gi 446175987 449 LAIVKSIVVAHKGTVAVTSDA-RGTRFVITLP 479
Cdd:COG4585 217 LRGMRERAEALGGTLTIGSAPgGGTRVRATLP 248
|
|
| COG3920 |
COG3920 |
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction ... |
321-480 |
5.86e-06 |
|
Two-component sensor histidine kinase, HisKA and HATPase domains [Signal transduction mechanisms];
Pssm-ID: 443125 [Multi-domain] Cd Length: 495 Bit Score: 48.75 E-value: 5.86e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 321 LAQADNNQLIpekkmlNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGD---PLMLrrALSNLLSNALRY----TPT 393
Cdd:COG3920 350 LYQSEDWEGV------DLRDYLRELLEPLRDSYGGRGIRIELDGPDVELPADaavPLGL--ILNELVTNALKHaflsGEG 421
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 394 GeTIVVRCQTVDHLVQVIVENPGTPIAPEhlprlfdrfyrVDPSRqrkgeGSGIGLAIVKSIVVAHKGTVAVTSDArGTR 473
Cdd:COG3920 422 G-RIRVSWRREDGRLRLTVSDNGVGLPED-----------VDPPA-----RKGLGLRLIRALVRQLGGTLELDRPE-GTR 483
|
....*..
gi 446175987 474 FVITLPA 480
Cdd:COG3920 484 VRITFPL 490
|
|
| Tar |
COG0840 |
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms]; |
167-317 |
8.36e-06 |
|
Methyl-accepting chemotaxis protein (MCP) [Signal transduction mechanisms];
Pssm-ID: 440602 [Multi-domain] Cd Length: 533 Bit Score: 48.09 E-value: 8.36e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 167 LYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKghaPIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVL 246
Cdd:COG0840 167 LEAAALALAAAALALALLAAALLALVALAIILALLLSRSITR---PLRELLEVLERIAEGDLTVRIDVDSKD-EIGQLAD 242
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446175987 247 SFNHMIERIEDVFTRQSNFS---ADIAHEIRTpitnliTQTEIALSQSRSQKELEDVLySNLEELTRMAKMVSD 317
Cdd:COG0840 243 AFNRMIENLRELVGQVRESAeqvASASEELAA------SAEELAAGAEEQAASLEETA-AAMEELSATVQEVAE 309
|
|
| COG4192 |
COG4192 |
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal ... |
269-467 |
1.49e-05 |
|
Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms];
Pssm-ID: 443346 [Multi-domain] Cd Length: 640 Bit Score: 47.37 E-value: 1.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 269 IAHEIRTPITNLIT---QTEIALSQSRSQKELEDVlySNLEELT-RMAKMVSDMLFLAQADNNQLIPekkmLNLADEVGK 344
Cdd:COG4192 440 LAHELNQPLNAMSMylfSAKKALEQENYAQLPTSL--DKIEGLIeRMDKIIKSLRQFSRKSDTPLQP----VDLRQVIEQ 513
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 345 VFDFFEALAEDRGVELRFVGDKcQVAGDPLMLRRALSNLLSNALRYTPTGETIVVRCQTVDHLVQVIVENPGT--PIApe 422
Cdd:COG4192 514 AWELVESRAKPQQITLHIPDDL-MVQGDQVLLEQVLVNLLVNALDAVATQPQISVDLLSNAENLRVAISDNGNgwPLV-- 590
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 446175987 423 hlPRLFDRFYrvdpsrQRKGEGSGIGLAIVKSIVVAHKGTVAVTS 467
Cdd:COG4192 591 --DKLFTPFT------TTKEVGLGLGLSICRSIMQQFGGDLYLAS 627
|
|
| PRK11086 |
PRK11086 |
sensory histidine kinase DcuS; Provisional |
353-479 |
3.48e-05 |
|
sensory histidine kinase DcuS; Provisional
Pssm-ID: 236839 [Multi-domain] Cd Length: 542 Bit Score: 46.06 E-value: 3.48e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 353 AEDRGVELRfVGDKCQV--AGDPLM---LRRALSNLLSNALRY---TPTGEtIVVRCQTVDHLVQVIVENPGTPIAPEHL 424
Cdd:PRK11086 407 ARELGITLI-ISEDSQLpdSGDEDQvheLITILGNLIENALEAvggEEGGE-ISVSLHYRNGWLHCEVSDDGPGIAPDEI 484
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446175987 425 PRLFDRFYRVdpsrqrKGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:PRK11086 485 DAIFDKGYST------KGSNRGVGLYLVKQSVENLGGSIAVESEpGVGTQFFVQIP 534
|
|
| glnL |
PRK11073 |
nitrogen regulation protein NR(II); |
372-479 |
1.17e-04 |
|
nitrogen regulation protein NR(II);
Pssm-ID: 182947 [Multi-domain] Cd Length: 348 Bit Score: 44.30 E-value: 1.17e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 372 DPLMLRRALSNLLSNALR-YTPTGETIVVRCQTVDHL------------VQVIVENPGTPiapehlPRLFDR-FYrvdPS 437
Cdd:PRK11073 234 DPDQIEQVLLNIVRNALQaLGPEGGTITLRTRTAFQLtlhgeryrlaarIDIEDNGPGIP------PHLQDTlFY---PM 304
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 446175987 438 RQRKGEGSGIGLAIVKSIVVAHKGTVAVTSDARGTRFVITLP 479
Cdd:PRK11073 305 VSGREGGTGLGLSIARNLIDQHSGKIEFTSWPGHTEFSVYLP 346
|
|
| NarQ |
COG3850 |
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction ... |
72-478 |
2.40e-04 |
|
Signal transduction histidine kinase NarQ, nitrate/nitrite-specific [Signal transduction mechanisms];
Pssm-ID: 443059 [Multi-domain] Cd Length: 448 Bit Score: 43.33 E-value: 2.40e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 72 RLMTLEDIVSGYSNVLISLADSQGKTVYHSPGAPDIREFTRDAIPDKDARGGEVYLLSGPTIMMPGHGHGHMEHSNWRMI 151
Cdd:COG3850 4 LLLLALALLRLLLALLALLLLALLLLSLLALLLLLERTLLRLLSLLASAGLLAALLAALLLLLSLGLLALLLALLLLLLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 152 NLPVGPLVDGKPIYTLYIALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKG-HAPIRSVSRQIQNITSKDLDV 230
Cdd:COG3850 84 LLLAALLSLLLLLLLLLLLLLLLLLLLLAAAINRKLALLRLLLALLLALLLAYLLRRRiVRPLRRLTQAAERIARGDFDA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 231 RLDPQTVPiELEQLVLSFNHMIERIEDVF------TRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSN 304
Cdd:COG3850 164 RVPVSGRD-ELGTLARAFNRMADELQELYaeleeeEELEAELELLALLDELLLLAALLLLLALLLALLLAALLAALLLLL 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 305 LEELTRMAKMVSDMLFLAQADNNQLIPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLL 384
Cdd:COG3850 243 LLQDALAESELLALNILAGLLELLLALLLLLLASALLLLELELLALLLELVELLALAAAEEALLLLVELAALLLLLLLQA 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 385 SNALRYTPTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSRQRKGEGSGIGLAIVKSIVVAHKGTVA 464
Cdd:COG3850 323 IANASLLLIALASVVAALLELASILALQAALEAAAAGAALAAAAAAAGLARALAQAGADAAEALGLLAEASEGAAGQGAG 402
|
410
....*....|....
gi 446175987 465 VTSDARGTRFVITL 478
Cdd:COG3850 403 LVDVEGGVAGEGGL 416
|
|
| HATPase_CckA-like |
cd16919 |
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar ... |
376-479 |
3.01e-04 |
|
Histidine kinase-like ATPase domain of two-component sensor hybrid histidine kinases, similar to Brucella abortus 2308 CckA; This family includes the histidine kinase-like ATPase (HATPase) domains of various two-component hybrid sensor histidine kinase (HKs) similar to Brucella abortus 2308 CckA, which is a component of an essential protein phosphorelay that regulates expression of genes required for growth, division, and intracellular survival; phosphoryl transfer initiates from the sensor kinase CckA and proceeds via the ChpT phosphotransferase to two regulatory substrates: the DNA-binding response regulator CtrA and the phospho-receiver protein CpdR. Proteins having this HATPase domain also contain a histidine kinase dimerization and phosphoacceptor domain (HisKA), a REC signal receiver domain, and some contain PAS or PAS and GAF sensor domain(s).
Pssm-ID: 340396 [Multi-domain] Cd Length: 116 Bit Score: 40.44 E-value: 3.01e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 376 LRRALSNLLSNALRYTPTGE--TIVVRCQTVD-------------HLVQVIVENPGTPIAPEHLPRLFDRFYRVDPSrqr 440
Cdd:cd16919 1 LELAILNLAVNARDAMPEGGrlTIETSNQRVDadyalnyrdlipgNYVCLEVSDTGSGMPAEVLRRAFEPFFTTKEV--- 77
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 446175987 441 kGEGSGIGLAIVKSIVVAHKGTVAVTSD-ARGTRFVITLP 479
Cdd:cd16919 78 -GKGTGLGLSMVYGFVKQSGGHLRIYSEpGVGTTVRIYLP 116
|
|
| HAMP |
COG2770 |
HAMP domain [Signal transduction mechanisms]; |
10-388 |
4.39e-03 |
|
HAMP domain [Signal transduction mechanisms];
Pssm-ID: 442051 [Multi-domain] Cd Length: 631 Bit Score: 39.71 E-value: 4.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 10 FSLATRLTFFISLATIAAFFAFAWIMIHSVKVHFAEQDINDLKEISATLERVLNHPDETQARRLMTLEDIVSGYSNVLIS 89
Cdd:COG2770 37 LALLLLLLLLLALLLLLLLLLLLLLAALVLLALLLAAALLLLLLLLSLVALAALLLALLLLLLLALLLLLAALLLLLLLA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 90 LADSQGKTVYHSPGAPDIREFTRDAIPDKDARGGEVYLLSGPTIMMPGHGHGHMEHSNWRMINLPVGPLVDGKPIYTLYI 169
Cdd:COG2770 117 ALALLLLLLLLLAALLALLLALALLALLLGLAAARLLLAALLALAAALALALGAGELLLLADLAAAIAALLAALLLLLLG 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 170 ALSIDFHLHYINDLMNKLIMTASVISILIVFIVLLAVHKGHAPIRSVSRQIQNITSKDLDVRLDPQTVPiELEQLVLSFN 249
Cdd:COG2770 197 GLLLVVLLEAALAALLLLLLLALLALLLALLLALLLARRITRPLRRLAEAARRIAAGDLDVRIPVSRKD-EIGELARAFN 275
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 250 HMIERIEDVFTRQSNFSADIAHEIRTPITNLITQTEIALSQSRSQKELEDVLYSNLEELTRMAKMVSDMLFLAQADNNQL 329
Cdd:COG2770 276 RMADSLRESIEEAEEEEELAEAELARLLEALLELLLALLLLLLALLLLAAAALLLELLLLLLLALLLLLLLAADLLLALA 355
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446175987 330 IPEKKMLNLADEVGKVFDFFEALAEDRGVELRFVGDKCQVAGDPLMLRRALSNLLSNAL 388
Cdd:COG2770 356 LAALLLLLALELLLEAELLVLLALEALALEAELAAVLALLAALAAALLLLELALEELVL 414
|
|
| HATPase_RsbW-like |
cd16936 |
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase ... |
379-478 |
4.71e-03 |
|
Histidine kinase-like ATPase domain of RsbW, an anti sigma-B factor and serine-protein kinase involved in regulating sigma-B during stress in Bacilli, and related domains; This family includes histidine kinase-like ATPase (HATPase) domain of RsbW, an anti sigma-B factor as well as a serine-protein kinase involved in regulating sigma-B during stress in Bacilli. The alternative sigma factor sigma-B is an important regulator of the general stress response of Bacillus cereus and B. subtilis. RsbW is an anti-sigma factor while RsbV is an anti-sigma factor antagonist (anti-anti-sigma factor). RsbW can also act as a kinase on RsbV. In a partner-switching mechanism, RsbW, RsbV, and sigma-B participate as follows: in non-stressed cells, sigma-B is present in an inactive form complexed with RsbW; in this form, sigma-B is unable to bind to RNA polymerase. Under stress, RsbV binds to RsbW, forming an RsbV-RsbW complex, and sigma-B is released to bind to RNA polymerase. RsbW may then act as a kinase on RsbV, phosphorylating a serine residue; RsbW is then released to bind to sigma-B, hence blocking its ability to bind RNA polymerase. A phosphatase then dephosphorylates RsbV so that it can again form a complex with RsbW, leading to the release of sigma-B.
Pssm-ID: 340413 [Multi-domain] Cd Length: 91 Bit Score: 36.48 E-value: 4.71e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 379 ALSNLLSNALRYT---PTGETIVVRCQTVDHLVQVIVENPGTPIAPEHLPrlfdrfyrvDPSRQRKgeGSGIGLAIVKSI 455
Cdd:cd16936 4 AVSEAVTNAVRHAyrhDGPGPVRLELDLDPDRLRVEVTDSGPGFDPLRPA---------DPDAGLR--EGGRGLALIRAL 72
|
90 100
....*....|....*....|...
gi 446175987 456 VvahkGTVAVTSDARGTRFVITL 478
Cdd:cd16936 73 M----DEVGYRRTPGGKTVWLEL 91
|
|
| CheA |
COG0643 |
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms]; |
444-479 |
5.04e-03 |
|
Chemotaxis protein histidine kinase CheA [Signal transduction mechanisms];
Pssm-ID: 440408 [Multi-domain] Cd Length: 563 Bit Score: 39.39 E-value: 5.04e-03
10 20 30
....*....|....*....|....*....|....*..
gi 446175987 444 GSGIGLAIVKSIVVAHKGTVAVTSDA-RGTRFVITLP 479
Cdd:COG0643 381 GRGVGMDVVKTNIEALGGTIEIESEPgKGTTFTLRLP 417
|
|
| HATPase_UhpB-NarQ-NarX-like |
cd16917 |
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to ... |
384-479 |
6.58e-03 |
|
Histidine kinase-like ATPase domain of two-component sensor histidine kinases similar to Escherichia coli UhpB, NarQ and NarX, and Bacillus subtilis YdfH, YhcY and YfiJ; This family includes the histidine kinase-like ATPase (HATPase) domains of various histidine kinases (HKs) of two-component signal transduction systems (TCSs) such as Escherichia coli UhpB, a HK of the UhpB-UhpA TCS, NarQ and NarX, HKs of the NarQ-NarP and NarX-NarL TCSs, respectively, and Bacillus YdfH, YhcY and YfiJ HKs, of the YdfH-YdfI, YhcY-YhcZ and YfiJ-YfiK TCSs, respectively. In addition, it includes Bacillus YxjM, ComP, LiaS and DesK, HKs of the YxjM-YxjML, ComP-ComA, LiaS-LiaR, DesR-DesK TCSs, respectively. Proteins having this HATPase domain have a histidine kinase dimerization and phosphoacceptor domain; some have accessory domains such as GAF, HAMP, PAS and MASE sensor domains.
Pssm-ID: 340394 [Multi-domain] Cd Length: 87 Bit Score: 35.61 E-value: 6.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175987 384 LSNALRYTPtGETIVVRCQTVDHLVQVIVENPGTPIAPEhlprlfdrfyrvdpsrqRKGEGSGIGLAIVKSIVVAHKGTV 463
Cdd:cd16917 9 LTNALKHAG-ASRVRVTLSYTADELTLTVVDDGVGFDGP-----------------APPGGGGFGLLGMRERAELLGGTL 70
|
90
....*....|....*..
gi 446175987 464 -AVTSDARGTRFVITLP 479
Cdd:cd16917 71 tIGSRPGGGTRVTARLP 87
|
|
| |
