|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
38-438 |
9.24e-149 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 428.68 E-value: 9.24e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 38 ITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFAT 117
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 118 GLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGII 197
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIEGVLGII 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 198 WSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDapvKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTW 277
Cdd:TIGR00893 161 WGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQ---GKGPSTPKKYQIKELLKDRRVWGLALGQFLVNIGLGFFLTW 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 278 FPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIICGLLISTCIMGANYTNDPMMIMC 357
Cdd:TIGR00893 238 FPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYVNIPYAALA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 358 LMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG-FAPALVYISAVALIGALSYIL 436
Cdd:TIGR00893 318 LVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGsFAGALMVVAALALIGALSYLL 397
|
..
gi 446175600 437 LV 438
Cdd:TIGR00893 398 LV 399
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
37-420 |
7.82e-146 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 420.63 E-value: 7.82e-146
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 37 FITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFA 116
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 117 TGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPL-LIWIQEMLSWHWVFIVTGGIG 195
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLvLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 196 IIWSLIWFKVYQPPRLTKGISKAELDYIRDggglVDGDAPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFL 275
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEE----PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGIL 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 276 TWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVAD-LLVRKGFSLGFARKTPIICGLLISTCIMGANYtndPMM 354
Cdd:TIGR00881 237 DWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDkLFNGRRGPLAVFFMALIIVSLLVYWLNPAANP---LMD 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175600 355 IMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPAL 420
Cdd:TIGR00881 314 LICLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAGAF 379
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-437 |
3.41e-101 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 306.03 E-value: 3.41e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 29 RYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSV 108
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 109 ATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVF 188
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 189 IVTGGIGIIWSLIWFKVYqpprltkgiskaeldyirdggglvdgdapvkkearqpltakdwklvfhRKLIGVYLGQFAVA 268
Cdd:cd17319 161 IIEGLLGLLLAVLWWFYL------------------------------------------------RQVWGLALGYFGIN 192
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 269 STLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLvrkgfsLGFARKTPIICGLLISTCIMGANY 348
Cdd:cd17319 193 YALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRL------LRGARRLVIIIGLLLAAVGLLLAY 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 349 TND-PMMIMCLMALAFFGNGFASIT-WSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQ-GYGFAPALVYISA 425
Cdd:cd17319 267 LTTsPVVAVILLSLAGFGIGAASPVfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDaTGSYTAAFLFLAA 346
|
410
....*....|..
gi 446175600 426 VALIGALSYILL 437
Cdd:cd17319 347 VALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
22-443 |
3.96e-74 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 236.69 E-value: 3.96e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 22 AAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFI 101
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 102 AIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEM 181
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 182 LSWHWVFIVTGGIGIIWSLIWFkvyqpprltkgiskaeldyirdggglvdgdapvkkearqpltakdwklvfhrklIGVY 261
Cdd:COG2271 161 FGWRAAFLILGLPGLLLALLRF------------------------------------------------------WLLA 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 262 LGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGfslgfaRKTPIICGLLIST 341
Cdd:COG2271 187 LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRR------KLVLAIGLLLAAL 260
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 342 CIMGANYTNDPMMIMCLMALA-FFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPAL 420
Cdd:COG2271 261 ALLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAF 340
|
410 420
....*....|....*....|...
gi 446175600 421 VYISAVALIGALSYILLVGDVKR 443
Cdd:COG2271 341 LLLAALALLAALLALLLLRETRK 363
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
34-436 |
1.16e-57 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 193.54 E-value: 1.16e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 34 VMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQ 113
Cdd:cd17380 2 ILLFLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 114 GFA--TGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAF---LTPLLIwiqEMLSWHWVF 188
Cdd:cd17380 82 PLLaySSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLgglIGPLLL---EYYGWPSVF 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 189 IVTGGIGIIWSLIWFKVYQPprltkgiskaeldyirdggglvdgdapvkkearqpltakdwklvfhrkLIGVYLGQFAVA 268
Cdd:cd17380 159 YFFGLLGLLWALVWLIYLPP------------------------------------------------VWAIIVAHFCMN 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 269 STLWFFLTWFPNYLTQEKGITAlKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIICGLLIST-CIMGAN 347
Cdd:cd17380 191 WGFYILLSWLPTYFHEVLVPLA-KGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPAlFLLLLS 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 348 YTNDPMMIMCLMALAFFGNGFASITWSL-VSSLAPmRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG-FAPALVYISA 425
Cdd:cd17380 270 HTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAP-NYAGIVFGISNTAGTIPGIVGVYLTGYILEATGsWSLVFVLAAV 348
|
410
....*....|.
gi 446175600 426 VALIGALSYIL 436
Cdd:cd17380 349 VNLVGAVVFLL 359
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-432 |
3.04e-43 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 156.19 E-value: 3.04e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 27 RRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGW 106
Cdd:COG2223 1 SGRWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 107 SVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHW 186
Cdd:COG2223 81 GIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRN 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 187 VFIVTGGIGIIWSLIWFKVYQpprltkgiskaeldyirdggglvdgDAPVKKEARQPLTAKDWKLVF-HRKLIGVYLGQF 265
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLR-------------------------DPPAGAAAAAKASLRDQLEALrDPRFWLLSLLYF 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 266 AVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLL-VRKGFSLGFArktpiicGLLISTCIM 344
Cdd:COG2223 216 GTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIgGRRVLLIVFA-------LMALGLLLL 288
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 345 GANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG-FAPALVYI 423
Cdd:COG2223 289 ALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVF 368
|
....*....
gi 446175600 424 SAVALIGAL 432
Cdd:COG2223 369 AVLALVALV 377
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
60-410 |
1.23e-36 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 138.52 E-value: 1.23e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 60 EFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFAT--GLMSLIGLRAITGIFEAPAF 137
Cdd:cd17318 50 EFDWSEKTQGIILSSFFYGYILTQIPGGYLAEKYGAKRVLGYSILITALLTLLTPLAArgGYGALIVLRILQGLAQGVTF 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 138 PTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPrltkgisk 217
Cdd:cd17318 130 PAMHALWAKWAPPLERSRLTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLVLPV-------- 201
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 218 aeldyirdggglvdgdapvkkearqpltakdWKLVfhrkligvyLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMT 297
Cdd:cd17318 202 -------------------------------WAIV---------VAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLS 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 298 TVPFLAAFVGVLLSGWVADLLVRKG-FSLGFARKTPIICGLLI-STCIMGANYTN-DPMMIMCLMALAFFGNGFASITWS 374
Cdd:cd17318 242 SLPYLAMWICSIVGGYLADWLRSRGiLSTTTVRKLFTSIGFLGpGVFLIALGYLGsNATLAVVFLTLSVGLSGACYSGFL 321
|
330 340 350
....*....|....*....|....*....|....*..
gi 446175600 375 L-VSSLAPmRLIGLTGGVFNFAGGLGGITVPLVVGYL 410
Cdd:cd17318 322 VnHLDLAP-NYAGTLMGITNTAATIAGIISPLIVGAI 357
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
35-404 |
2.59e-34 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 131.00 E-value: 2.59e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 35 MIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQG 114
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 115 FATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGI 194
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 195 GIIWSLIWFKVYQPPRLTKgiskaeldyirdggglvdgdaPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFF 274
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKR---------------------PKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGL 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 275 LTWFPNYLtQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFarktpIICGLLISTCIMGANYTNDPMM 354
Cdd:pfam07690 220 LTYLPLYQ-EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLA-----LLLLILAALGLLLLSLTLSSLW 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|.
gi 446175600 355 IMCLMALAFFGNGFASITW-SLVSSLAPMRLIGLTGGVFNFAGGLGGITVP 404
Cdd:pfam07690 294 LLLALLLLGFGFGLVFPALnALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
23-400 |
1.49e-33 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 128.94 E-value: 1.49e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 23 AKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIA 102
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 103 IFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEML 182
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 183 SWHWVFIVTGGIGII-WSLIWFKVyqpprltkgiskaeldyirdggglvdgdAPVKKEARQPLTAKDWKLVFHRKLIGVY 261
Cdd:COG2814 162 GWRWVFLVNAVLALLaLLLLLRLL----------------------------PESRPAARARLRGSLRELLRRPRLLLLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 262 LGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRkgfslgfaRKTPIICGLLIST 341
Cdd:COG2814 214 LLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGR--------RRLLLIGLLLLAL 285
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 342 CIMGANYTNDPMMIMCLMALAFFGNGFA-SITWSLVSSLAPMRLIGLTGGVFNFAGGLGG 400
Cdd:COG2814 286 GLLLLALAGSLWLLLLALFLLGFGFGLLfPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
59-438 |
3.20e-32 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 125.77 E-value: 3.20e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 59 EEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFP 138
Cdd:cd17325 24 ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWP 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 139 TNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKgiska 218
Cdd:cd17325 104 AAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEPRPPP----- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 219 eldyirdggglvdgdaPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTT 298
Cdd:cd17325 179 ----------------NKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 299 VPFLAAFVGVLLSGWVADllvRKGfslgfaRKTPIICGLLIST-CIMGANYTNDPMMIMCLMALAFFGNGFASITW-SLV 376
Cdd:cd17325 243 AQGLASALSQPPAGKLSD---RIG------RKPLILIGLLLSAvALLLLPLATSFWLLLLLLALLGLGLGLVFPATlALL 313
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 377 SSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:cd17325 314 ADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
36-432 |
3.32e-28 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 114.83 E-value: 3.32e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 36 IFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGF 115
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 116 ATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWI--QEMLSWHWVFIVTGG 193
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILasSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 194 IGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLvdgdapvkkearqpltakdWKLVFHRKLIGVYLGQFAVASTLWF 273
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------KRVLKNPGLWLLLLAIFLVNLAYYS 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 274 FLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADllvrkgfsLGFARKTPIICGLLISTCIMGA--NYTND 351
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD--------RLIGRKPLLLIGLLLMALGLALllLAPSL 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 352 PMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGA 431
Cdd:cd06174 294 LLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLA 373
|
.
gi 446175600 432 L 432
Cdd:cd06174 374 A 374
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
29-438 |
1.34e-26 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 110.06 E-value: 1.34e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 29 RYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSV 108
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 109 ATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVF 188
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAF 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 189 IVTGGIGIIWSLIWFKVY--QPPRLtkgiskaeldyirdggglvdgdapvkkearqpltakdWKLVFhrkligVYLGQFA 266
Cdd:cd17312 161 LVPGIVGLVVAIILFFFLrdSPPYV-------------------------------------WVLSL------AYAFVYI 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 267 VASTlwfFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRkgfslgfARKTPII----CGLLISTC 342
Cdd:cd17312 198 VRYA---CLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG-------GRRAPIAviymLLMTLSLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 343 IMGANYTNDPMMIMCLMALAFFGNGFASITWSLVS-SLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALV 421
Cdd:cd17312 268 LFWFFPHNKLLSIVLLFLIGFFVGGPINLIGGAAAqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFY 347
|
410
....*....|....*..
gi 446175600 422 YISAVALIGALSYILLV 438
Cdd:cd17312 348 FLISAALLSVLLLLSLW 364
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
50-432 |
8.31e-25 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 105.01 E-value: 8.31e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 50 LAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAIT 129
Cdd:cd17475 15 IPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLV 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 130 GIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPP 209
Cdd:cd17475 95 GAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREP 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 210 RLTKGISKAEldyirdggglvdgdAPVKKEARQPLTAKDWKLVFhrkLIGVYL--GQFAVastlwffLTWFPNYLTQEKG 287
Cdd:cd17475 175 PAASAATESA--------------STLLRSLKEVLRNRDVWLIA---IAGALLvaPQFAL-------LTFLLLFLHDHLG 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 288 ITALKAGFMTTVPFLAAFVGVLLSGWVADlLVRKGFSLGFARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNG 367
Cdd:cd17475 231 LSVVAAGALLAVAQLGGALGRIGLGRVSD-RVFGGRRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAIG 309
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175600 368 FASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQG-YGFAPALVYISAVALIGAL 432
Cdd:cd17475 310 WNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDAtHSYAPAWLALALLLVLAAL 375
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
33-438 |
8.73e-25 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 105.40 E-value: 8.73e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 33 LVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLF 112
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 113 QGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVG--LAFLTPLLIwIQEMLSWHWVFIV 190
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGsgLGYVVGGLV-AQATGGWRWAFRV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 191 TGGIGIIWS-LIWFKVYQPPRLTKGISKAELDYIRDggglvdgdapvkkearqplTAKDWKLVFHRK-----LIGVYLGQ 264
Cdd:cd17328 160 TGVLGVLLAiLLLLFVREPPRGAAEGGVMAKSTATS-------------------FLADLKALAKNPsfilsTLGFTAVS 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 265 FAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGfslgfARKTPIIC--GLLISTC 342
Cdd:cd17328 221 FVTGALAFWAPTFFLRAFGVGDLSSADVGLIFGAITCIAGVLGVLLGGILADRLRRKT-----PRADPLVCavGLLAAAP 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 343 IMGANYTNDPMMIMCLMALAFFGNGFASITWSLVS----SLAPMRLIGLTGGVFNFAGG-LGGITVPLVVGYLAQGYGFA 417
Cdd:cd17328 296 FLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFaillYVVIPTRRSTASAIQILLSHlLGDAGSPYLIGLISDLLRQN 375
|
410 420
....*....|....*....|.
gi 446175600 418 PALVYISAVALIGALSYILLV 438
Cdd:cd17328 376 KDSPLAEAASLQYALLLCSFV 396
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
33-404 |
9.45e-25 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 105.41 E-value: 9.45e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 33 LVMIFITVVICYVDRANLAVAS-AHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATL 111
Cdd:cd17327 7 LPLLCILYFLQYLDKSNISNAAvMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGLLTL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 112 FQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEML------SWH 185
Cdd:cd17327 87 LTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYGVFKILgvgglaGWR 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 186 WVFIVTGGIGIIWSLIWFKVYQ-PPRLTKGISKAELDYIRDGGGLVDGDAPVKKearqpLTAKDWKLVFHR-KLIGVYLG 263
Cdd:cd17327 167 WLFIIEGLITIIIGLVIFFWLPdNPSKAWFLTEEEKELAVERLRANQTGKGDQK-----FKWKQIKEAFKDpRTWLLFLF 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 264 QFAVASTLWFFLTWFPNYLTQEKGiTALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPII-CGLLISTC 342
Cdd:cd17327 242 FFCSQITNNGISNFLPLILKSLGF-YSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLALVgSIILLAAP 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 343 IMGANYTNdpmmimCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVP 404
Cdd:cd17327 321 NPPGAYFA------AYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
29-436 |
5.61e-24 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 103.09 E-value: 5.61e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 29 RYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSV 108
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 109 ATLFQGFATGLMSLIGLRAI----TGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEML-- 182
Cdd:cd17345 81 INILIGFVPSATSSVGLMFIllflNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLGLAIFgd 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 183 -SWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAElDYIRDggglvDGDAPVKKEARQPLTAKD--WKLVFHRKL-- 257
Cdd:cd17345 161 gWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIE-EYKGD-----YPEEADGEEEEQELSAWEifVKYVLKNKLlw 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 258 ------IGVYLGQFAVastlwffLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRkgfslGFARKT 331
Cdd:cd17345 235 yiaianVFVYLVRYGI-------LDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFK-----GRRAPT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 332 PIICGLLISTCIMGANYTNDPMMIM-CLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVP-LVVGY 409
Cdd:cd17345 303 GIIFMILVIVALIVYWLAPNVLVDLiALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLGGSVLAtALIGI 382
|
410 420
....*....|....*....|....*....
gi 446175600 410 LAQGYGFAPA--LVYISAVALIGALSYIL 436
Cdd:cd17345 383 IVDHFGWNGGfiVLLASCILAIIFLALVA 411
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
60-437 |
1.65e-23 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 101.61 E-value: 1.65e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 60 EFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPT 139
Cdd:cd17371 28 EFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGEWAA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 140 NNRMVTSWFPEHERASAVGFYTSGQFVGL---AFLTPLLI-WIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKgi 215
Cdd:cd17371 108 GAALMAEYVPARHRGKALGYVQSGWAVGWllaTLLAALLFpLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQA-- 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 216 skaeldyirdggglvdgdapvKKEARQPLTAKDWKL-VFHRKLIGVYLGQFAVASTL----WFFLTWFPNYLTQEKGITA 290
Cdd:cd17371 186 ---------------------ARAARRHFADRPSLReLFSPPLLRTTLLASLLATGAlggyYGITTWLPSYLTGERGLSF 244
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 291 LKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFArktpiICGLLISTCIMGANYTNDPMMIMcLMALAFFGNGFAS 370
Cdd:cd17371 245 EGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNFALFA-----LGSAISILLYFFLPLSPTLILIL-GFPLGFFASGPFS 318
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175600 371 ITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd17371 319 GMGAYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSGSLGTAIAVFAAVYYIAGLVLALL 385
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
66-408 |
1.88e-23 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 102.13 E-value: 1.88e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 66 AEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLF--QGFATGLMSLIGLRAITGIFEAPAFPTNNRM 143
Cdd:TIGR00894 76 ALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVipWAAGGGIALVVFCRVIQGLAQGSVSPATHKI 155
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 144 VTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWI-QEMLSWHWVFIVTGGIGIIWSLIWF-KVYQPPRLTKGISKAELD 221
Cdd:TIGR00894 156 IVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLcESWGGWPMIFYVFGIVGCAWSLLWFvFPADDPSIHPCISKFEKK 235
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 222 YIrdGGGLVDGDAPvkkeARQPLTAKdwKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPF 301
Cdd:TIGR00894 236 YI--NSSLQGQKGS----TRQSLPIK--AIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKENGLLSSLPY 307
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 302 LAAFVGVLLSGWVAD-LLVRKGFSLGFARKtpIICG---LLISTCIMGANYTNdpMMIMCLMALAFFGNGFASITWSLVS 377
Cdd:TIGR00894 308 LFAWLCSIFAGYLADfLKSSKTLSLTAARK--IFNGiggLGPGIFAYALPYLS--AAFYLTIIILTLANAVSSGPLAGVL 383
|
330 340 350
....*....|....*....|....*....|....
gi 446175600 378 SLAPM---RLIGLTGGVFNFAGGLGGITVPLVVG 408
Cdd:TIGR00894 384 INSLDlapRFLGFIKGITGLPGFIGGLIASTLAG 417
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
22-437 |
3.17e-23 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 100.70 E-value: 3.17e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 22 AAKPGRRRYLTLVMIFITVVICYvdrANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFI 101
Cdd:COG0738 2 SKKNYRRALIAIYLLFFLWGFAT---ALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 102 AIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERA---SAVGFYTSGQFVGlAFLTPLLIWI 178
Cdd:COG0738 79 GLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAASrlnLLHAFFSLGALLG-PLLGGLLILL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 179 QEMLSWHWVFIVTGGIGIIWSLIWFKVYQPprltkgiskaeldyirdggglvdgDAPVKKEARQPLTAKDWKLVFHRKLI 258
Cdd:COG0738 158 GLSLSWHLPYLILAVLLLLLALLFLRSKLP------------------------EIEEEEEEAAGSAASLKSLLKNPRLL 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 259 GVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRkgfslgfaRKTPIICGLL 338
Cdd:COG0738 214 LGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGP--------VRLLRLSALL 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 339 ISTCIMGANYTNDPMMIMCLMALAFFGNgfaSITWSLVSSLAPMRL---IGLTGGVFNFAGGLGGITVPLVVGYLAQGYG 415
Cdd:COG0738 286 AAVGLLLALLAPGPWLALIGLALVGLGL---SLMFPTIFSLALDGLgkrTAAAVSAVLIMGIVGGAIGPPLIGFLADAFG 362
|
410 420
....*....|....*....|..
gi 446175600 416 FAPALVYISAVALIGALSYILL 437
Cdd:COG0738 363 LRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
33-432 |
4.91e-22 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 96.90 E-value: 4.91e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 33 LVMIFITVVICYVDRANLAVASAHIQEEF--GITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVAT 110
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEFslGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 111 LFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLS----WHW 186
Cdd:cd17316 81 LLIGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 187 VFIVTGGIGIIwsliwfkvyqpprltkgiskaeldyirdggglvdgdapvkkearqpltakdwKLVFHRKLIGVYLGQFA 266
Cdd:cd17316 161 LFLIGALPALL----------------------------------------------------ALLLRRRTLLLILLWFF 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 267 VASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFArktpiICGLLISTCIMGA 346
Cdd:cd17316 189 ISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGL-----ILSGILALPLFYL 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 347 NYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAV 426
Cdd:cd17316 264 LSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALILAL 343
|
....*.
gi 446175600 427 ALIGAL 432
Cdd:cd17316 344 LAIVAL 349
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
57-437 |
4.44e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 94.17 E-value: 4.44e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPA 136
Cdd:cd17474 25 IAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAAGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 137 FPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLtPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLtkgis 216
Cdd:cd17474 105 GPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVG-PLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPEPKE----- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 217 kaeldyirdggglvdgdapvKKEARQPLTAKDWKLVFHRKLIG-VYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGF 295
Cdd:cd17474 179 --------------------KAKSSSATKLRDLKKALRGRGLLtFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGL 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 296 MTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFArktpiICGLLISTCIMGANyTNDPMMIMCLMAL-AFFGNGFASITwS 374
Cdd:cd17474 239 LFAGWSVLLALGSLFVGRLLKKRFGARRILVIG-----LLLYALSLLLLGFV-PSLALLLIAIVLFgLGLGLNLPLLT-T 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175600 375 LVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd17474 312 LVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
20-411 |
4.60e-21 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 94.35 E-value: 4.60e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 20 VNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTY 99
Cdd:TIGR00895 6 IRKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 100 FIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQ 179
Cdd:TIGR00895 86 LWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 180 EMLSWHWVFIVTGGIGIIWS-LIWFKVYQPPRLT--KGISKAELDYIRDGGGLVDGDAPVKKEARQplTAKDWKLVFH-- 254
Cdd:TIGR00895 166 PVFGWRSLFYVGGIAPLLLLlLLMRFLPESIDFLvsKRPETVRRIVNAIAPQMQAEAQSALPEQKS--TQGTKRSVFKal 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 255 ------RKLIGVYLGQFAVASTLWFFLTWFPnYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGfa 328
Cdd:TIGR00895 244 fqgktaRITVLLWLLYFMLLVGVYFLTNWLP-KLMVELGFSLSLAATGGALFNFGGVIGSIIFGWLADRLGPRVTALL-- 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 329 rktPIICGLLIStcIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVG 408
Cdd:TIGR00895 321 ---LLLGAVFAV--LVGSTLFSPTLLLLLGAIAGFFVNGGQSGLYALMALFYPTAIRATGVGWAIGIGRLGAIIGPILAG 395
|
...
gi 446175600 409 YLA 411
Cdd:TIGR00895 396 YLL 398
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
57-436 |
9.91e-20 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 90.30 E-value: 9.91e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPA 136
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGF 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 137 FPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIwSLIWFKVYQPPRltkgis 216
Cdd:cd17324 105 WAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALL-AALLLWRLLPSL------ 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 217 kaeldyirdggglvdgdaPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFM 296
Cdd:cd17324 178 ------------------PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGL 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 297 TTVPFLAAFVGVLLSGWVADLLVRKGFSLGFArkTPIICGLLIstcIMGANYTNDPMMIMCLMALAFFGNGFASITW-SL 375
Cdd:cd17324 240 LLLFGVAGVVGSPLAGRLADRGGRRALLIALL--LLAAALLLL---TLLGPSPLLLLVGLVLWGLGFFAAHSALQTRvLR 314
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446175600 376 VSSLAPMRLIGLTGGVFNFAGGLGGitvpLVVGYLAQGYGFApALVYISAVALIGALSYIL 436
Cdd:cd17324 315 LAPEARGLASSLYLAAYNLGGALGA----ALGGLVLDHGGWA-GVGWVGAALLLLALLLAL 370
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
50-439 |
1.39e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 89.92 E-value: 1.39e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 50 LAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAIT 129
Cdd:cd17321 15 VNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQ 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 130 GIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIwsliwfkvyqpp 209
Cdd:cd17321 95 GIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLV------------ 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 210 rltkgiskaeldyirdggglvdgdapvkkearqpltakdwKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGIT 289
Cdd:cd17321 163 ----------------------------------------ALLLARTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYS 202
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 290 ALKAGFMTTVPFLAAFVGVLLSGWVADllvRKGFslgfarKTPIICGLLISTCIMG--ANYTNDPMMIMCLMALAFFGNG 367
Cdd:cd17321 203 PLQAGLALLPLALAMLVAAPLAGRLAD---RFGP------RLVLVAGLLLTAVGLLllALLGADSSVWLLLPGLVLLGLG 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 368 ---FASITWSLVSSLAPMRLIGLTGGVFNFAGGLGG-ITVPLVVGYLAQGYGF------APALVYISAVALIGALSYILL 437
Cdd:cd17321 274 lglFATPLTNAALSSVPKEKAGAASGILNTARQLGGaLGVALLGALLTAGLSAnlgdsgVAALLSAAAAAFAAGFHLAFL 353
|
..
gi 446175600 438 VG 439
Cdd:cd17321 354 VA 355
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
22-312 |
6.12e-19 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 86.79 E-value: 6.12e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 22 AAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFI 101
Cdd:COG0477 5 DAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLI 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 102 AIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEM 181
Cdd:COG0477 85 GLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 182 LSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGGLVDGDAPVKKEARQPLTAKDWKLVFHRKLIGVY 261
Cdd:COG0477 165 LGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLA 244
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446175600 262 LGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSG 312
Cdd:COG0477 245 LLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALLL 295
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
16-437 |
8.68e-18 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 84.92 E-value: 8.68e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 16 MDIPVNAAKPGRRRYLTLVMIFITVVICYVdRANLAVASA---HIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDR 92
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNL-RPAITSVGPllpEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARR 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 93 VGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHeRASAVGFYTSGQFVGLAFLT 172
Cdd:COG2807 80 FGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAA 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 173 PLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRltkgiskaeldyirdggglvdgdapvkKEARQPLTAKDWKLV 252
Cdd:COG2807 159 GLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRRP---------------------------AAAAAAPAAASLRSL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 253 FHRKLIGVYLGQFAVASTLWF-FLTWFPNYLtQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKgfslgfaRKT 331
Cdd:COG2807 212 WRSPLAWLLTLFFGLQSLLYYaVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDR-------RPL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 332 PIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPM-RLIGLTGGVFNFAGGLGGITVPLVVGYL 410
Cdd:COG2807 284 LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTpAEAAALSGMAQSVGYLLAALGPLLVGAL 363
|
410 420
....*....|....*....|....*...
gi 446175600 411 AQGYG-FAPALVYISAVALIGALSYILL 437
Cdd:COG2807 364 HDATGsWTAALLLLAALAVLMLVAGLLA 391
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
69-436 |
1.74e-17 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 84.06 E-value: 1.74e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 69 GYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFAT--GLMSLIGLRAITGIFEAPAFPTNNRMVTS 146
Cdd:cd17381 68 GWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAAdlGAGYLIAVRALEGLGEGVTFPAMHAMWAS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 147 WFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPprltkgiskaeldyirdg 226
Cdd:cd17381 148 WAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFLWIWLVMP------------------ 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 227 gglvdgdapvkkearqpltakdwklvfhrkLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFV 306
Cdd:cd17381 210 ------------------------------LWAIVVAHFSYNWTFYTLLTLLPTYMKEILRFDIQENGFLSALPYLGCWL 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 307 GVLLSGWVADLLVRK-GFSLGFARKTPIICGL------LISTCIMGANYTndpmMIMCLMALAFFGNGFASITWSLVS-S 378
Cdd:cd17381 260 FMILSGQIADNLREKqNFSTVCVRKIFTLIGMigpavfLLAAGFTGCNYS----LAVAFLTISSTLGGFSASGFNINHlD 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446175600 379 LAPmRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAP--ALVYISA-VALIGALSYIL 436
Cdd:cd17381 336 IAP-SYAGILLGITNTFATIPGMVGPVIAKSLTHNNTVEEwqTVFYISAaINVFGAIFFTI 395
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
50-436 |
4.18e-15 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 76.59 E-value: 4.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 50 LAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIA--IFGWSVATLFQG----FATGLMSLI 123
Cdd:cd17333 15 LGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGllLISLALALIFATpsiyLFVVLMFLA 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 124 GLRAitGIFEAPAfptnNRMVTSWFPE--HERASAV-GFYTSGQFVGLAFLTPLliwIQEMLSWHWVFIVTGGIGIIWSL 200
Cdd:cd17333 95 GLGA--GILDTGA----NTFVGALFEEssATRLNVLhGFFGLGALIGPLIATSL---LTSELSWSWAYLIIGLIYLLLAI 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 201 IWFKVYQPPRLTKGISKAeldyirdggGLVDGDAPVKKEARQPltakdwklvfhrKLIGVYLGQFAVASTLWFFLTWFPN 280
Cdd:cd17333 166 LILLTLFPELPSARNPQQ---------SVGAFSASASRLLRNP------------SIILGALALFLYVGAETAFSSWVPS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 281 YLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADllvrkgfSLGFARKTPIICGLLISTCIMGANYTNDPMMIMCLMA 360
Cdd:cd17333 225 YLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISR-------RIKPHTLLVLSGSGALLGLLILLLAPTLVVGLVATAL 297
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446175600 361 LAFFGNGFASITWSLVSSLAPmRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYIL 436
Cdd:cd17333 298 LGLFMAALFPTILSLGISNLP-YAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLALL 372
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
50-413 |
6.41e-15 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 76.08 E-value: 6.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 50 LAVASAHIQEEFGITKAEMGYVFSAFawLYTLC-QIP-GGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRA 127
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSY--LLALAiMIPlSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRI 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 128 ITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGII----WSLIWF 203
Cdd:cd17503 93 LQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILalllAPLLDL 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 204 KVYQPPRLTKGIskaeldyirdggglvdgdapvkkearqpltakdwklvfhrklIGVYLGQFAVASTlwFFLtwFPNYLT 283
Cdd:cd17503 173 RLFKDRNFTLGL------------------------------------------LLSFLLGLGLFGA--MFL--LPLYLQ 206
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 284 QEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICGLLIS--TCIMGANYTND--PMMIMCLM 359
Cdd:cd17503 207 NVLGYSAFESGLVLAPGGLASAILSPLVGRLLDK---------FGPRLLLLAGLLLLalGTLLLAFLTPDtsLWLIILPL 277
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446175600 360 ALAFFGNG--FASITWSLVSSLaPMRLIGLTGGVFNFAGGLGG-ITVPLVVGYLAQG 413
Cdd:cd17503 278 FIRGLGMGlvFMPLNTLALNSL-PPEQIGDATALFNTIRQLGGsIGTALLATLLTNR 333
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
87-437 |
5.92e-14 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 72.99 E-value: 5.92e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 87 GWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFV 166
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 167 GLAFLTPLLIWIQEmLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKgiskaeldyirdggglvdgdaPVKKEARQPLTA 246
Cdd:cd17473 136 GGVVFLLLGGALAE-IGWRAPFLVYLLALPVLILVLLFLPEPARKSK---------------------SAASPGAATAAA 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 247 KDWKLVFhrkliGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLvrkgfslg 326
Cdd:cd17473 194 LPWKRVL-----PIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRL-------- 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 327 FARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFA-SITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPL 405
Cdd:cd17473 261 GKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLlPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPL 340
|
330 340 350
....*....|....*....|....*....|...
gi 446175600 406 VVGYLAQGYGFAPALVYISAV-ALIGALSYILL 437
Cdd:cd17473 341 VLGPLVNLTGGLSGAFLILGVlALVLAIVLLLL 373
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
60-438 |
7.33e-14 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 72.63 E-value: 7.33e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 60 EFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPT 139
Cdd:cd17489 25 DLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 140 NNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPprltkgiskae 219
Cdd:cd17489 105 AATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDP----------- 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 220 ldyirdggglvdgdaPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLtQEKGITAlkAGFMTTV 299
Cdd:cd17489 174 ---------------PPVAAEEAEAGTRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYA-AERGISN--AGLFFTV 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 300 PFLAAFVGVLLSGWVADllvRKGFslgfaRKTPIICGLLISTCIMGANYTNDPMMImcLMALAFFGNGFASI---TWSLV 376
Cdd:cd17489 236 YAIALLLSRPFSGKLSD---RKGP-----KTVIIPGLLLLALGLLLLSFAGSPWML--LLAAVLYGLGFGLLfpaLQALA 305
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 377 SSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:cd17489 306 VDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFLL 367
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
31-206 |
1.57e-13 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 72.41 E-value: 1.57e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 31 LTLVMIfITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAwLYTLCQIP-GGWFLDRVGSRVTYFIAIFGWSVA 109
Cdd:TIGR00711 3 LTIVLM-LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYM-LANAISIPlTGWLAKRFGTRRLFLISTFAFTLG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 110 TLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFI 189
Cdd:TIGR00711 81 SLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFL 160
|
170
....*....|....*..
gi 446175600 190 VTGGIGIIWSLIWFKVY 206
Cdd:TIGR00711 161 INVPIGIIVVVVAFFIL 177
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
33-437 |
1.74e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 71.46 E-value: 1.74e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 33 LVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLF 112
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 113 QGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTG 192
Cdd:cd17365 81 TAFAQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 193 GIGIIWsliwfkvyqpprltkgiskaeldyirdggglvdgdapvkkearqpltakdwkLVFHRKLIGVYLGQFAVASTLW 272
Cdd:cd17365 161 VPPLIL----------------------------------------------------LPLLRGTLLLWVTFFMGLLLVY 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 273 FFLTWFPnYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFArktpiiCGLLISTCIMGANYTNDP 352
Cdd:cd17365 189 LLNSWLP-KLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVLALFF------ALGAVSLALLGVSPASLV 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 353 MMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYL-AQGYGFAPALVYISAVALIGA 431
Cdd:cd17365 262 LLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGWALGVGRLGAILGPLLGGLLlAAGLGPESVFLALAIPAALGA 341
|
....*.
gi 446175600 432 LSYILL 437
Cdd:cd17365 342 LAVLLL 347
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
60-415 |
1.96e-13 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 71.60 E-value: 1.96e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 60 EFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFAT--GLMSLIGLRAITGIFEAPAF 137
Cdd:cd17382 43 EFNWTPETVGLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNMLIPIAArvHYGCVIFVRILQGLVEGVTY 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 138 PTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPprltkgisk 217
Cdd:cd17382 123 PACHGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLVSMP--------- 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 218 aeldyirdggglvdgdapvkkearqpltakdwklvfhrkLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMT 297
Cdd:cd17382 194 ---------------------------------------VYAIIVANFCRSWTFYLLLISQPAYFKEVFGFDISKVGILS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 298 TVPFLAAFVGVLLSGWVADLLVRKGFSLGFARKTPIICG--LLISTCIMGANYTNDPMMIMCLMALAFFGNGFAsITWSL 375
Cdd:cd17382 235 ALPHLVMTIIVPIGGQLADYLRSRGILSTTAVRKIFNCGgfGMEATFLLVVAFSHSPTVAISFLVLAVGFSGFA-ISGFN 313
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 446175600 376 VSSL--APmRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG 415
Cdd:cd17382 314 VNHLdiAP-RYASILMGISNGIGTLSGMVCPVIVGALTKHKT 354
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
57-435 |
1.15e-12 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 69.12 E-value: 1.15e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPA 136
Cdd:cd17478 22 LIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAF 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 137 FPTNNRMVTSwFPEHERASAVGFYTSGQFVGLAfLTPLLIWI----QEMLSWHWVFIVtggIGIIWSLIWFKVYQPPRlt 212
Cdd:cd17478 102 HPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFA-LGPLIAAAlvalFGGLGLLILLII---PGLAVALLLLRLRPLKK-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 213 kgiskaeldyirdggglvdgdaPVKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQeKGITALK 292
Cdd:cd17478 175 ----------------------PEAKKAAAKSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTTFLPFYLVQ-RGYSLVF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 293 AGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICGLLIST-CIMGANYTNDPMMIMCLMALAFFGNGFASI 371
Cdd:cd17478 232 AGLLLSLFLFAGAIGTLIGGPLSDR---------FGRRRVIIASLLLAApFLLLFLLTPGIWSYILLVLAGFLLFASFPV 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446175600 372 TWSLVSSLAPMRlIGLTGGVFN-FAGGLGGITVPlVVGYLAQGYGFAPALVYISAVALIGALSYI 435
Cdd:cd17478 303 TVVLAQELLPGN-VGLASGLMMgLSFGLGGIGAP-VLGALADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
20-443 |
3.73e-12 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 67.68 E-value: 3.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 20 VNAAKPGRRRYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTY 99
Cdd:PRK11551 4 RTSSASSSRLALTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRIL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 100 FIAI--FG-WSVATlfqGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLI 176
Cdd:PRK11551 84 IVSValFGlFSLAT---AQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 177 WIQEMLSWHWVFIVtGGIG---IIWSLIWFkvyqpprltkgiskaeldyirdgggLVDGDAPVKKEARQPLTAKDWKLVF 253
Cdd:PRK11551 161 LAAGDAAWRHIFYV-GGVGpllLVPLLMRW-------------------------LPESRAFAQAAGAGKQRAPVLRALF 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 254 ----HRKLIGVYLGQFAVASTLWFFLTWFPNyLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLvRKGFSLGFar 329
Cdd:PRK11551 215 gegrATATLLLWISYFFTLIVLYFLLNWLPS-LLVGQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL-RPRRVVLL-- 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 330 ktpIICGLLISTCIMGANYTNDPMMIMCLMAlAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGY 409
Cdd:PRK11551 291 ---IYAGILASLAALAAAPSFAGMLLAGFAA-GLFVVGGQSVLYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQ 366
|
410 420 430
....*....|....*....|....*....|....*
gi 446175600 410 -LAQGYGFAPALVYISAVALIGALSYILLVGDVKR 443
Cdd:PRK11551 367 lLALGRSTVGVIGASIPVILVAALAALLLVSRPSR 401
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
8-203 |
9.00e-12 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 66.45 E-value: 9.00e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 8 PKIWRKLAMDIPVNAAKPGRRRYLTLVMIFITVVICYVDRANL-AVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPG 86
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALePFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 87 GWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFV 166
Cdd:cd17325 256 GKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSL 335
|
170 180 190
....*....|....*....|....*....|....*..
gi 446175600 167 GLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWF 203
Cdd:cd17325 336 GMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFL 372
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
57-437 |
3.82e-11 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 64.14 E-value: 3.82e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIfEAPA 136
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGI-GGAV 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 137 FPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIwsliwfkvyqpprltkgis 216
Cdd:cd17504 101 FPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVL------------------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 217 kaeldyirdGGGLVdgdapvkkearqPLTakDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFM 296
Cdd:cd17504 162 ---------LAALV------------PLI--DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTPTGFGLGITE 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 297 TTVPFLAAFVGVLLSGWVADLLVRKgfslgFARKTPIICGLLIST--CIMGANYTNDPMMIMCLMALAFFGNG--FASIT 372
Cdd:cd17504 219 AGLLLLPGALVMLIAGPLAGRLIAR-----VGPRRVLLIGLVISAvgLLLLALLHSSLWALVVALLLIGIGLGlaFASLP 293
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175600 373 WSLVSSLAPMR---LIGLTGGVFNFAGGLGGI---------TVPLVVGYLAQGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd17504 294 NIVVESVPPDRtgiATGMNTVLRTIGSAIGPAiagailttyTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLI 370
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
58-437 |
5.43e-11 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 64.15 E-value: 5.43e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 58 QEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSR-------VTYFIAIFGWSVATLFQGFATGLMSLIGLRAITG 130
Cdd:COG2211 38 TDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrrrpwILIGAIPLALSFVLLFTAPDLSPTGKLIYALVTY 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 131 IFEAPAFPTNNRMVTSWFPE-----HERASAVG----FYTSGQFVGLAFLTPLLIWI--QEMLSWHWVFIVTGGIGIIWS 199
Cdd:COG2211 118 LLLGLAYTLVNIPYSALGAEltpdyEERTRLSSwrfaFAGLGGLLASVLPPPLVAAFggDAALGYRLTALIFAVLGLLAF 197
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 200 LIWFkvyqppRLTKgiskaeldyirdggglvdgDAPVKKEARQPLtAKDWKLVF-HRKLIGVYLGQFAVASTLWFFLTWF 278
Cdd:COG2211 198 LLTF------FGTK-------------------ERPVPEEEKVSL-KESLKALLkNRPFLLLLLAYLLFFLALALVAALL 251
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 279 PNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICGLLISTCIMGANY---TNDPMMI 355
Cdd:COG2211 252 LYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR---------FGKKKAFIIGLLLAALGLLLLFflgPGNLWLL 322
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 356 MCLMALAFFGNGFA-SITWSLVSSLAP-------MRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVA 427
Cdd:COG2211 323 LVLAALAGIGLGAIlVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAAQSPSAL 402
|
410
....*....|
gi 446175600 428 LIGALSYILL 437
Cdd:COG2211 403 TGIRLLFFLL 412
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
55-437 |
1.38e-10 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 62.57 E-value: 1.38e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 55 AHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLI-GLRAITGIFE 133
Cdd:cd17352 27 VELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYlTYGVLGGLGL 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 134 APAFPTNNRMVTSWFpEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLiwfkvyqpprltk 213
Cdd:cd17352 107 GLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCV------------- 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 214 giskaeldyirdgGGLVdgdapvkkearqpltakdwkLVFHRKLIGVYLGQFAVASTLWFF--LTWFPNYLTqEKGITAL 291
Cdd:cd17352 173 -------------CGLL--------------------LRLLKDPTFVLLALGVSFAMLGFFvpFVYLPSYAK-SLGIDES 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 292 KAGFMTTVPFLAAFVGVLLSGWVADLLVRKGFSLGFArkTPIICGLLISTCIMGANYTNdpMMIMCLmALAFFGNGFASI 371
Cdd:cd17352 219 DAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYIF--TLLILGLSLLAFPLATTYVG--LIVFSV-LFGFCSGSYSSL 293
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446175600 372 TWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLA-QGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd17352 294 TPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRdYTGDYDAAFYFCGACLLLSGVLLFLL 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
33-205 |
1.76e-10 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 62.20 E-value: 1.76e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 33 LVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLD-RVGSRVTYFIAIFGWSVATL 111
Cdd:cd17474 201 LTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKkRFGARRILVIGLLLYALSLL 280
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 112 FQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVT 191
Cdd:cd17474 281 LLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVG 360
|
170
....*....|....
gi 446175600 192 GGIGIIWSLIWFKV 205
Cdd:cd17474 361 AAIALAAAVLLALL 374
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
69-197 |
6.20e-10 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 57.27 E-value: 6.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 69 GYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWF 148
Cdd:TIGR00880 1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446175600 149 PEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGII 197
Cdd:TIGR00880 81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
57-437 |
1.34e-09 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 59.55 E-value: 1.34e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSL-IGLRAITGIFEAP 135
Cdd:cd17353 29 LSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLfLGYGVLGGIGAGI 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 136 AFPTNNRMVTSWFPEHeRASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRltKGI 215
Cdd:cd17353 109 GYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIRDPP--KGW 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 216 SKAELDYIRDGGGLVDGDAPVKKEARQPLTakdWKLvfhrkligvYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGF 295
Cdd:cd17353 186 VPPGVDPLANNAENSPRDYTPREMLRTPTF---WLL---------WLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAAL 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 296 MTTVPFLAAFVGVLLSGWVADLlvrkgfsLGFARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNG-FASITWS 374
Cdd:cd17353 254 AVSILSIFNGGGRPFWGWLSDK-------IGRKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIGFCYGgGFALFPA 326
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175600 375 LVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd17353 327 LTADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
56-438 |
1.44e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 59.55 E-value: 1.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 56 HIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAP 135
Cdd:cd17329 25 YLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGL 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 136 AFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAfLTPLLIWIQEMLSWHWVFIVTGG---IGIIWSLIWFKVYQPPRlt 212
Cdd:cd17329 105 FEPASEAMIADVTTPENRTRAFSLLYWAINLGVA-IGPLLGGLLLLYSFRLLFLAAAVlflLAALVLLFLLPETRPKR-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 213 kgiskaeldyirdggglvdgdapvkKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWF-FLTWFPNYLTQEKGITAL 291
Cdd:cd17329 182 -------------------------RAAEKTEILRGYKIVLRDRAFLLFLLASFLISLIYFqLESTLPVYVVEILGLGES 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 292 KAGFMTTvpfLAAFVGVLLSGWVADLLVRKGFslgfaRKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFAS- 370
Cdd:cd17329 237 LLGLLLA---LNALLIVLLQFPVARLVERFRL-----RKILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFp 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446175600 371 ITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:cd17329 309 AVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
35-441 |
1.96e-09 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 59.27 E-value: 1.96e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 35 MIFITVVICY----VDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVAT 110
Cdd:cd17343 3 TIFASMFVGYtlyyFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 111 LFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPeherASAVGFY-----TSGQFVGLafLTPLLI-WIQEMLSW 184
Cdd:cd17343 83 VAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFS----PSQFGTWwsvlsTSMNLAGS--LGPILAtLLALSYGW 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 185 HWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDYIRDGGglvdgdapvKKEARQPLTAKDwkLVFHRKLIGVYLGQ 264
Cdd:cd17343 157 RSTLSISGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKK---------KKSPRGESTLKE--LLLSPFLWLLSLGY 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 265 FAVASTLWFFLTWFPNYLTQEKGITALKA-GFMTTVPfLAAFVGVLLSGWVADLLVRK--GFSLGFARKTPIICGLLIST 341
Cdd:cd17343 226 LVVFGVKTAVTDWGQLFLIQDKGQSALTGsSFMSSLE-VGGFVGSIAAGYLSDWAVAKhgSSSRGNPRMPLALVFMAGLT 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 342 CIMGA-----NYTNDPMMIMCL-MALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG 415
Cdd:cd17343 305 VSLHLfrvhiTSDSSELFILLLgFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYD 384
|
410 420
....*....|....*....|....*.
gi 446175600 416 FAPALVYISaVALIGALSYILLVGDV 441
Cdd:cd17343 385 WRTAFLLLE-ILCAITVVILFLLRNI 409
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
87-425 |
3.69e-09 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 58.40 E-value: 3.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 87 GWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFV 166
Cdd:PRK12307 74 GLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKSKASAFLVSGFGI 153
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 167 GLAFLTPLLIWIQEMLSWHWVFIVtgGIGIIWSLIWFKVYQPPRltkgiSKAELDYIRDGGGlvdgdapvKKEARQPLTA 246
Cdd:PRK12307 154 GNIIAAYFMPSFAEAYGWRAAFFV--GLLPVLLVIYIRARAPES-----KEWEEAKLSGKGK--------HSQSAWSVFS 218
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 247 KDWKLVFHRKLIGVYLGQFAVASTL----WFFLTWFPNYLTQEKGITALKAGFMTTVPFlAAFVGVLLSGWVADLL-VRK 321
Cdd:PRK12307 219 LSMKGLFNRAQFPLTLCVFIVLFSIfganWPIFGLLPTYLAGEGFDTGVVSNLMTAAAF-GTVLGNIVWGLCADRIgLKK 297
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 322 GFSLGFARKTPIICGLLIstcIMGANYTndpMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGI 401
Cdd:PRK12307 298 TFSIGLLMSFLFIFPLFR---IPQDNYL---LLGACLFGLMATNVGVGGLVPKFLYDYFPLEVRGLGTGLIYNLAATSGT 371
|
330 340
....*....|....*....|....
gi 446175600 402 TVPLVVGYLAQGYGFAPALVYISA 425
Cdd:PRK12307 372 FNSMAATWLGITMGLGAALTFIVA 395
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
50-432 |
4.44e-09 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 57.57 E-value: 4.44e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 50 LAVASAHIQEEFGiTKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAIT 129
Cdd:cd17502 15 VATALPTIVAEFG-GLSLVSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQ 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 130 GIFEAPAFPTNNRMVTSWFPEHERASAVGfYTSGQFVGLAFLTPLL-IWIQEMLSWHWVFIVTGGIGIIwsliwfkvyqp 208
Cdd:cd17502 94 GIGGGGLMSLAFIIIADLVPPRERGKYQG-YIGAVFGIASVAGPLIgGAFTDHLSWRWCFYINLPIGGL----------- 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 209 prltkgiskaeldyirdggglvdgdapvkkearqpltakdwKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGI 288
Cdd:cd17502 162 -----------------------------------------ALALLRTILLSSIFGFLFGGALFGLIYYLPLYFQLVLGD 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 289 TALKAGFMTTVPFLAAFVGVLLSGWVADLLVRKgfslgfarKTPIICGLLISTCIMGA----NYTNDPMMIMCLMALAFF 364
Cdd:cd17502 201 SATKSGVRLLPLIIGLVIGSIISGALISKTGRY--------KPLIVIGTILMSVGAGLlttlTLDTSKWLLIGYLILLGL 272
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446175600 365 GNGFA-SITWSLVSSLAPMRLIGLTGGVFNFAGGLGGitvplVVGyLAQGYGFAPALVyISAVALIGAL 432
Cdd:cd17502 273 GLGIGfQQPLVAVQNAVPPADVGVATATNTFFRSLGG-----TLG-VAITDVFLVALA-LAALAFLLSL 334
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
260-438 |
6.67e-09 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 57.43 E-value: 6.67e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 260 VYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICGLLI 339
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---------FGRRRVLLIGLLL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 340 S--TCIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFA 417
Cdd:pfam07690 72 FalGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWR 151
|
170 180
....*....|....*....|.
gi 446175600 418 PALVYISAVALIGALSYILLV 438
Cdd:pfam07690 152 AAFLILAILSLLAAVLLLLPR 172
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
71-437 |
1.12e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.85 E-value: 1.12e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 71 VFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMS-----LIGLRAITGIFEAPAFPTNNRMVT 145
Cdd:cd06173 39 VLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwlLLVLAFLLGIASAFFGPARQALLP 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 146 SWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGG-IGIIWSLIWFKVYQPPRLTKGISKAELDYIR 224
Cdd:cd06173 119 ELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALsFLLSALLLLFIRRPPPAAPGESSSLLLRDLR 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 225 DGGglvdgdapvkkearqpltakdWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAA 304
Cdd:cd06173 199 EGL---------------------RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGA 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 305 FVGVLLSGWVADLLVRkgfslgfaRKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITW-SLVSSLAPMR 383
Cdd:cd06173 258 LLGALLLGRLSKRRRR--------GRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLnTLLQLRVPDE 329
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 446175600 384 LIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd06173 330 LRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
27-210 |
1.71e-08 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 56.04 E-value: 1.71e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 27 RRRYLTLVMIFITVVICYVdrANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGW 106
Cdd:COG2223 204 DPRFWLLSLLYFGTFGSFI--GFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLIVFALM 281
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 107 SVATLFQGFATG-LMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEML-SW 184
Cdd:COG2223 282 ALGLLLLALALGsLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATgSY 361
|
170 180
....*....|....*....|....*.
gi 446175600 185 HWVFIVTGGIGIIWSLIWFKVYQPPR 210
Cdd:COG2223 362 TAAFLVFAVLALVALVLTLLLYRRPR 387
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
57-432 |
2.49e-08 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 55.74 E-value: 2.49e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPA 136
Cdd:cd17355 29 IIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGT 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 137 FPTN-NRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGI--GIIWSLIWFKVYQPPrltk 213
Cdd:cd17355 109 LAAVaFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLalLVLVPVLLLLRRRPA---- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 214 giskaeldyirdggglvDGDAPVKKEARQPLTAKDWKLVF-HRKLIGVYLGQFAVASTLWFFLTWFPNYLtQEKGITALK 292
Cdd:cd17355 185 -----------------DLALRAYDDASPASPGSTLKEALrSASFWLLALAFFLCGFAVVGLIVHLVPYL-ADRGISPAA 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 293 AGFMTTVPFLAAFVGVLLSGWVADLLVRKgfslgfARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASIT 372
Cdd:cd17355 247 AAVALALIGLFNIVGRLLSGWLGDRYSPR------RLLAASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLT 320
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446175600 373 WSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG-FAPALVYISAVALIGAL 432
Cdd:cd17355 321 AALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGsYTAAWALAVALGLIAAL 381
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
32-205 |
8.94e-08 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 53.73 E-value: 8.94e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 32 TLVMIFITVVIcYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATL 111
Cdd:cd17323 1 VFIISFLTFVV-TFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 112 FQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGlAFLTPLL-IWIQEMLSWHWVFIV 190
Cdd:cd17323 80 GCALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLG-PALGPIIgGFITQSLGWRWIFWF 158
|
170
....*....|....*...
gi 446175600 191 T---GGIGIIWSLIWFKV 205
Cdd:cd17323 159 LaiiSGFCLILIFLFLPI 176
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
29-320 |
1.10e-07 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 53.56 E-value: 1.10e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 29 RYLTLVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSV 108
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 109 ATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVF 188
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYGWRAGM 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 189 IVTGGIGI---IWsLIWFKVYQPPRLtkgiskaeldyirdggglvdgdapvkkearqpltakdWKLVFHRKLigVYLGQF 265
Cdd:cd17488 161 YVPGIIAIlmgIV-LCWRLRDRPPYI-------------------------------------WLLAFCYVL--VYVVRT 200
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*
gi 446175600 266 AVAStlwffltWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVR 320
Cdd:cd17488 201 AIND-------WGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK 248
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
12-435 |
2.72e-07 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 52.74 E-value: 2.72e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 12 RKLAMDIPVNAAkpgRRRYLTLVM-IFITVVICYVD----RANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPG 86
Cdd:PRK09556 8 RKPTLDLPLEVQ---RKMWFKPFMqSYLVVFIGYLTmyliRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLV 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 87 GWFLD-RVGSRVTYF------IAIFGWSVATLFQGFATGLMslIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGF 159
Cdd:PRK09556 85 GYYADgKNTKQFLPFllilsaICMLGFGASLGSGSVSLGLM--IALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 160 YTSGQFVGLAFLTPLLIWIQEMLSWHWV---FIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELDY---IRDGGGLVDGD 233
Cdd:PRK09556 163 WNISHNLGGAGAGGVALWGANYFFDGHVigmFIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFgepISEEDKETEST 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 234 APVKKEARQPLTAKD---WKLVFHRklIGVYLGQFAVAStlwffltWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLL 310
Cdd:PRK09556 243 DMTKWQIFVEYVLKNpviWLLCFAN--IFLYIVRIGIDN-------WSPVYAFQELGFSKEDAINTFTLFEIGALVGSLL 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 311 SGWVADLLV-RKGFslgfarkTPIICGLLISTCIMG-ANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLT 388
Cdd:PRK09556 314 WGWLSDLANgRRAL-------VACIALALIIFTLGVyQHATSEYMYLASLFALGFLVFGPQLLIGVAAVGFVPKKAIGVA 386
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 389 GGVF---------NFAG-GLGGITVPL-----VVGYLAQGYGFAPALVYISAVALIGALSYI 435
Cdd:PRK09556 387 NGIKgtfaylfgdSFAKvGLGMIADPTkngtpIFGYTLTGWAGTFAALDIAAIGCICLMAIV 448
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
27-204 |
2.96e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 52.23 E-value: 2.96e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 27 RRRYLTLVMIFITVVICYVDrANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGW 106
Cdd:cd06173 206 RSPLLRLLLLALALFALLGG-ALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLL 284
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 107 SVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHW 186
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSA 364
|
170
....*....|....*...
gi 446175600 187 VFIVTGGIGIIWSLIWFK 204
Cdd:cd06173 365 VFLLAGALLLLAALLLLL 382
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
257-432 |
3.07e-07 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 52.28 E-value: 3.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 257 LIGVYLGQFAVASTLWFFLTWFPnYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICG 336
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADR---------FGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 337 LLIST--CIMGANYTNDPMMIMCLMALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGY 414
Cdd:COG2814 82 LLLFAlgSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170
....*....|....*...
gi 446175600 415 GFAPALVYISAVALIGAL 432
Cdd:COG2814 162 GWRWVFLVNAVLALLALL 179
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
28-320 |
5.90e-07 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 51.63 E-value: 5.90e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 28 RRYLTLVMiFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRvtYFIAI--FG 105
Cdd:PRK11663 21 RRHILITM-YLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNAR--YFMGIglIA 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 106 WSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAfLTPLLI-WIQEMLSW 184
Cdd:PRK11663 98 TGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGA-LIPLVVgAIALHYGW 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 185 HWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKA--------ELDYIRDGGGLvdgdapvkkEARQPLTakdwKLVFHRK 256
Cdd:PRK11663 177 RYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVgewrhdalELAQQQEGAGL---------SRKEILT----KYVLLNP 243
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 257 LIG--------VYLGQFAVAStlwffltWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLLVR 320
Cdd:PRK11663 244 YIWllsfsyvlVYVVRAAIND-------WGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFN 308
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
265-440 |
6.91e-07 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 51.03 E-value: 6.91e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 265 FAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADllvRKGfslgfARKTPIICGLLISTCIM 344
Cdd:COG2223 14 FFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVD---RFG-----PRRVLLIGLLLLGIGLL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 345 GANYTNDPMMIMCLMALAFFGNGFASITW-SLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYI 423
Cdd:COG2223 86 LLALAVSYWLLLLLGLLLGIGGGGSFAVGiALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLIL 165
|
170
....*....|....*..
gi 446175600 424 SAVALIGALSYILLVGD 440
Cdd:COG2223 166 GILLLVVAVLAWLFLRD 182
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
57-437 |
1.58e-06 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 49.88 E-value: 1.58e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPA 136
Cdd:cd17320 25 IARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAG 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 137 FPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAfLTPLL-IWIQEMLSWHWVFIVTGGIGII---WSLIWFKVYQPPRlt 212
Cdd:cd17320 105 SVVARAIVRDLYSGAELAKIFSLLMMILAIAPA-LAPLLgGLLLLFFGWRAIFVFLALLGLLlllLVLLFLPETLPEE-- 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 213 kgiskaeldyirdggglvdgdapvKKEARQPLTAKDWKLVFHRKLIGVYLGQFAVASTLWF-FLTWFPNYLTQEKGITAL 291
Cdd:cd17320 182 ------------------------KRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFaYLAAAPFIYIEQLGLSPA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 292 KAGFMTTVPFLAAFVGVLLSGWVA-----DLLVRKGFSLGfarktpIICGLLISTCIMGANYTNDPMMImcLMALAFFGN 366
Cdd:cd17320 238 QFGLLFALNAIALILGSLLNGRLVrrfgpRRLLRLGLLLL------LAAALVLLLAALLGGLSLWPLVA--PLFLIFFGF 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 367 GFA-SITWSLVSSLAPMRlIGLTGGVFNFAGGLGGITVPLVVGYLAQGyGFAPALVYISAVALIGALSYILL 437
Cdd:cd17320 310 GLIfPNATSLALEPFPHV-AGTASALLGFLQFLIGALAGALVGLLPNG-TALPMGLLILVLGLLALLLLILL 379
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
86-432 |
2.18e-06 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 49.58 E-value: 2.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 86 GGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMS---LIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFY-- 160
Cdd:pfam00083 66 AGKLGDRFGRKKSLLIANVLFVIGAVLQGAAKGKWSvyqLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYql 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 161 --TSGQFVGlAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKAELD--YIRDGGGLVDGDAPV 236
Cdd:pfam00083 146 aiTFGILLA-YIFGLGLNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVEKGRLEEAreVLAKLRGVPDVDREL 224
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 237 KKEAR-----QPLTAKDWKLVFHRK------LIGVYLgQFAVASTLWFFLTWFPNYLTQEKGitaLKAGFMTTVPFLA-A 304
Cdd:pfam00083 225 DEIKDsleagQEAEKASWKELFSTKtrrqrlLIGVML-QIFQQLTGINAIFYYSTTIFENLG---LSDSFLVTIIVGVvN 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 305 FVGVLLSGWVADLLVRK-GFSLGFArkTPIICGLLIstCIMGANYTNDP------MMIMCLMALAFFGNGFASITWSLVS 377
Cdd:pfam00083 301 FVFTFIAIFLVDRFGRRpLLLLGAA--GMAICFVIL--GIVALLGVSKSdwagivAIVFIALFIAFFAMGWGPVPWVIVS 376
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446175600 378 SLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGAL 432
Cdd:pfam00083 377 ELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFFIFAGLLVLFII 431
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
87-197 |
2.71e-06 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 49.34 E-value: 2.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 87 GWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFV 166
Cdd:PRK10504 66 GWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQV 145
|
90 100 110
....*....|....*....|....*....|.
gi 446175600 167 GLAFLTPLLIWIQEMLSWHWVFIVTGGIGII 197
Cdd:PRK10504 146 GPLLGPALGGLLVEYASWHWIFLINIPVGII 176
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
50-437 |
2.72e-06 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 49.14 E-value: 2.72e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 50 LAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAIT 129
Cdd:cd17472 16 LPVLSVYAKSLPGATPTLIGLALGIYGLTQAIFQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQ 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 130 GI--FEAPAFPtnnrMVTSWFPEHERASAVGFYtsGQFVGLAFLTPLLI--WIQEMLSWHWVFIVTGGIGII-WSLIWFK 204
Cdd:cd17472 96 GSgaISSVVMA----LLADLTREENRTKAMALI--GASIGIAFAISMVLgpLLAAHLGVSGLFLITAILSLVsLLILLFF 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 205 VYQPPRLTKGISKAELDYIrdggglvdgdapvkkearqpltakdwKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQ 284
Cdd:cd17472 170 VPDPPKIVQISEKEKKKLK--------------------------KLLKNKRLLRLDFSIFILHFVLMAFFYILPLLLTQ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 285 EkgitALKAGFMTTVpFLAAFVGVLLSGWVADLLVRKGFSLgfaRKTPIICGLLISTC--IMGANYTNDPMMIMclmALA 362
Cdd:cd17472 224 L----GGGKGQLWKV-YLPAILIGFILMVPFVIYAEKKGKM---KQVFVSSILLIAVGflLLLFAATSLWLLII---GLI 292
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446175600 363 FFGNGFASIT---WSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILL 437
Cdd:cd17472 293 IFFIGFNLLEallPSLVSKIAPKEYRGTAMGIYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTILILALLWLLVSFLL 370
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
59-432 |
2.92e-06 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 49.09 E-value: 2.92e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 59 EEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFP 138
Cdd:cd17477 24 EREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFV 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 139 TNNRMVTSWFPEHERASAVGFYTSGQFVGLAfLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGISKA 218
Cdd:cd17477 104 VSESWLNALATNENRGRVLGLYSTVLGLGFA-LGPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 219 ELDYIRdggglvdgdapvkkeaRQPLTakdwklvfhrkLIGVYLGQFAVAStlwfFLTWFPNYLTQeKGITALKAGFMTT 298
Cdd:cd17477 183 LRRLLR----------------IAPLA-----------LLGAFVAGFLEGA----FYSLLPLYGLR-LGLSVAQAALLLA 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 299 VPFLAAFVGVLLSGWVADLLVRkgfslgfaRKTPIICGLLISTCIMGANYTNDPMMImcLMALAFFGNGFASITWSLVSS 378
Cdd:cd17477 231 AFVLGGLLLQWPLGWLADRFDR--------RRVLLGCALLGALAALLLPLVPGLPLA--LLVLLFLWGGAAGPLYTLALA 300
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446175600 379 LA-----PMRLIGLTGGvFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGAL 432
Cdd:cd17477 301 LAgdrlpGDELVAANAA-LLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLL 358
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
33-432 |
4.11e-06 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 48.79 E-value: 4.11e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 33 LVMIFITVVICYVDRANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLF 112
Cdd:cd17341 1 LHLSWLSFFLGFMVWFLFAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 113 QGFA-TGLMSLIGLRAITGIFEApAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLA---FLTPLLI-WIQEMLS---W 184
Cdd:cd17341 81 LALAvSSYWGLLVLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAvsqLLAPLIAgAIVFDGGfvgW 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 185 HWVFIVTGGIGIIWSLIWFKVYQpprltkgiskaeldyirdggglvdgDAPVKKEARQPLTAKDWKLVFHRK---LIGVY 261
Cdd:cd17341 160 RNAFFVPGILLAIAAVLVLLFGD-------------------------DLPTGKASALEFLKVQLAVLKNYRtwiLSLLY 214
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 262 LGQFAVASTlwfFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfsLGFARKTPI------IC 335
Cdd:cd17341 215 GVTFGSFVG---FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDR-------FGGRRRLWWlfivmtIG 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 336 GLLIStcIMGANYTNDPMMIMCLMALAFFGNGFASitwSLVSSLAPMRLIGLTGGVFNF---AGGLGGITVPLVVGYLAQ 412
Cdd:cd17341 285 AALLS--LSLPTSGTNLVLFLALFVALGLGAGAGN---GSVFRMVPFIFRRELGAVTGLvgaIGGLGGFFLPLLFGSSAL 359
|
410 420
....*....|....*....|
gi 446175600 413 GYGFAPALVYISAVALIGAL 432
Cdd:cd17341 360 MTGSGVGAFSLFGVLAVACT 379
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
255-438 |
6.75e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 47.95 E-value: 6.75e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 255 RKLIGVYLGQFAVASTLWFFLTWFP---NYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADllvRKGfslgfARKT 331
Cdd:COG2807 14 AGRWLLLLAIVLVALNLRPAITSVGpllPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLAR---RFG-----LERT 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 332 PIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFASITW-SLVSSLAPMRlIGLTGGVFNFAGGLGGITVPLVVGYL 410
Cdd:COG2807 86 LLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLpGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPL 164
|
170 180
....*....|....*....|....*...
gi 446175600 411 AQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:COG2807 165 AAALGWRGALAVWALLALLALLLWLPLL 192
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
59-438 |
8.71e-06 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 47.60 E-value: 8.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 59 EEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSR-VTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIfEAPAF 137
Cdd:cd17490 24 ESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRkLFIIIGLLFTVLASLIMILFPSPWGLLIARFLSGI-AAATW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 138 PTNNRMVTSWFPEHERASAVGFYTSGQFVG--LAFLTPLLIwiQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLTKGI 215
Cdd:cd17490 103 VSFTVLYASYFPPDEAAKAMGLINLVNNLGqlIAFLIGGLI--AEHFGMRAPFLLAALAGVLGFILSLFIKEERREKKPV 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 216 SKAELDYIRdggglvdgdapvkkearqplTAKDWKLVFHRKLIGvyLGQFAVASTLWFFLtwfPNYLTQEkGITALKAGF 295
Cdd:cd17490 181 LTELKELLS--------------------VLKDKKLLFFSLLAI--LQQMITFSTTFGFT---PLIAKQL-GASSFQLGL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 296 MTTVPFLAAFVGVLLSGWVAdllvrkGFSLGfARKTPIICGLLISTCIMGANYTNDPMMIMCLMALAFFGNGFA-SITWS 374
Cdd:cd17490 235 LSIIYLLPNALASLLSGTLF------YKKLG-ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALNGFGTGILfPLLMS 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446175600 375 LVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:cd17490 308 LSIEGVPAEQRSTAMGFFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
87-433 |
1.34e-05 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 47.14 E-value: 1.34e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 87 GWFLDRVGSRVTYFIAIFGWSVATLFQGF-----ATGLMS---LIGLRAITGIFEAPAFPTNNRMVTSWFPEHERasavG 158
Cdd:cd17369 65 GHFGDRIGRKKTLVLTLLLMGIATFLIGLlptyaQIGILApilLVLLRLLQGLALGGEWGGAVLMAVEHAPPKRR----G 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 159 FYTS--------GQFVGLAFLTPLLIWIQE--MLSWHW--VFIVTGGIGIIWSLIWFKVYQPPRLTKgiskaeldyirdg 226
Cdd:cd17369 141 FYGSfpqlgapvGLLLATGVFLLLSALLSDeaFLSWGWriPFLLSAVLVAVGLYIRLRLEETPVFRR------------- 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 227 ggLVDGDAPVKKEARQPLTaKDWKLVFHRklIGVYLGQFAVASTLWFFLTwfpNYLTQEKGITALKAGFMTTVPFLAAFV 306
Cdd:cd17369 208 --AKEAGQVVRAPLVEVLR-RHWRALLLA--IGLRLAENVLFYLFTTFAL---SYATQTLGVDRSTVLLAVLIASVVAAI 279
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 307 GVLLSGWVADLlvrkgfslgFARKTPIICGLLISTCIM----GANYTNDPMMIMCLMALAFFG--NGFASITWSLVSSLA 380
Cdd:cd17369 280 TIPLFGWLSDR---------VGRRPVYLAGALLAALFAfpffWLLDTGSTWLIVLAAVVVLGVlhGMMYGPQAAFLAELF 350
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 446175600 381 P--MRLIGLTGGvFNFAGGLGGITVPLVVGYL-AQGYGFAPALVYISAVALIGALS 433
Cdd:cd17369 351 PtrVRYTGASLG-YQLGAILGGGFAPLIATALvAATGSWWPVALYLAALAVISLVA 405
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
58-210 |
1.94e-05 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 46.77 E-value: 1.94e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 58 QEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAF 137
Cdd:COG0738 238 KDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMF 317
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446175600 138 PTNNRMVTSWFPEHeRASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPR 210
Cdd:COG0738 318 PTIFSLALDGLGKR-TAAAVSAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVPLVCYLLILLLALALKRKRR 389
|
|
| MFS_DtpA_like |
cd17346 |
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily ... |
61-433 |
2.10e-05 |
|
Dipeptide and tripeptide permease A (DtpA)-like subfamily of the Major Facilitator Superfamily of transporters; The DtpA-like subfamily includes four Escherichia coli proteins: dipeptide and tripeptide permeases A (DtpA, TppB or YdgR), B (DtpB or YhiP), C (DtpC or YjdL), and D (DtpD or YbgH). They are proton-dependent permeases that transport di- and tripeptides. DtpA and DtpB display a preference for di- and tripeptides composed of L-amino acids. DtpC shows higher specificity for dipeptides compared to tripeptides, and prefers dipeptides containing a C-terminal lysine residue. The DtpA-like subfamily belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340904 [Multi-domain] Cd Length: 399 Bit Score: 46.41 E-value: 2.10e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 61 FGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRV-GSRVTYFIAIFGWSV--ATLFQGFATGLMSLIGLRAI---TGIFEa 134
Cdd:cd17346 35 DGFSEADAASIYGAYTALVYLTPIIGGWLADKVlGARRTVFIGGILMALgyLLLALSPFSVSMLYLGLALIivgNGLFK- 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 135 pafPTNNRMVTSWFPEHE--RASAVGFYTSGQFVGlAFLTPLLI-WIQEMLSWHWVFIVtGGIGIIWSLIWFKVYqpprl 211
Cdd:cd17346 114 ---PNISSLVGKLYDENDprRDSGFSIFYMGINLG-AFLAPLLCgTLGDNYGYHYGFGL-AAVGMLLGLLIFLLG----- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 212 tkgiskaeldyirdggglvdgdapvkkearqpltakdWKLVFHRKLIGVYLGQFAVASTLWFF-------LTWFPNYLTQ 284
Cdd:cd17346 184 -------------------------------------RKKLLERKKMLAIIILFLFAVVFWAIyeqagtsLALFADENVD 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 285 EK--GITALKAGFMTTVPFLAAFVGVLLsGWVADLLVRKGFSLGFARKTPIICGLL-ISTCIM---GANYTNDPMMIMCL 358
Cdd:cd17346 227 RLlgGFTIPPSWFQSLNPLFIILLAPIL-AALWTKLGKRGKDPSIPTKFALGLLLLgLSFLLMvlaASFAGGSGKVSALW 305
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 359 MALAFFGNGFA-----SITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYG-FAPALVYISAVALIGAL 432
Cdd:cd17346 306 LVLSYFLQTLGelclsPVGLSMITKLAPAKFAGFMMGLWFLASALGNILAGYLAGFYAQPKDpLASALVYTDYFGLIGVI 385
|
.
gi 446175600 433 S 433
Cdd:cd17346 386 A 386
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
278-437 |
6.13e-05 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 44.87 E-value: 6.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 278 FPNYLtQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICGLLIST-----CIMGANYTNdp 352
Cdd:cd17325 19 LPLYA-ESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDR---------FGRKRLLLLGLLLLAvstllFAFATSYWQ-- 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 353 mmimcLMALAFFGNGFASITW----SLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGF-APALVYISAVA 427
Cdd:cd17325 87 -----LLLARFLQGLASAAVWpaamALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYrAPFLVCAALAL 161
|
170
....*....|
gi 446175600 428 LIGALSYILL 437
Cdd:cd17325 162 LALVLALLLL 171
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
57-190 |
8.03e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 44.69 E-value: 8.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 57 IQEEFGITKAEMGYVFSAF---AWLytlcqipGGWFL----DRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAIT 129
Cdd:PRK03893 46 VQGEFGLTTVQAASLISAAfisRWF-------GGLLLgamgDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVI 118
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446175600 130 GIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSWHWVFIV 190
Cdd:PRK03893 119 GMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI 179
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
27-201 |
8.39e-05 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 44.51 E-value: 8.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 27 RRRYLTLVMIFITVVICYVdrANLAVASAHIQEEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGW 106
Cdd:cd17316 176 RRRTLLLILLWFFISFGYY--GLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILS 253
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 107 SVAT--LFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQFVGLAFLTPLLIWIQEMLSW 184
Cdd:cd17316 254 GILAlpLFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGG 333
|
170
....*....|....*..
gi 446175600 185 HWVFIVTGGIGIIWSLI 201
Cdd:cd17316 334 TGVPALILALLAIVALI 350
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
23-203 |
4.63e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 42.15 E-value: 4.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 23 AKPGRRRYLTLVMIFItVVICYVDRANLAVASAhiqeEFGITKAEMGYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIA 102
Cdd:cd17370 196 KKLPKAFWLYLLAVAL-FALGNFSFAFLILRAQ----ELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILG 270
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 103 IFGWSVATLFQGFATGLMSLIGLRAITGIFEApAFPTNNRMVTSWF-PEHERASAVGFYTSGQFVGLAFLTPLLIWIQEM 181
Cdd:cd17370 271 YLSLALAYLGFALGSSLWLLLLGFILWGLYMG-AQESIERAAVADLvPAELRGTAYGLFNTVVGIGWLLASLIAGYLWDL 349
|
170 180
....*....|....*....|..
gi 446175600 182 LSWHWVFIVTGGIGIIWSLIWF 203
Cdd:cd17370 350 ISPSAAFLFSAVLALIALLLLL 371
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
260-444 |
8.65e-04 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 41.43 E-value: 8.65e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 260 VYLGQFAVASTLWFFLTWFPNYLtQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADllvrkgfslGFARKTPIICGLLI 339
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLYA-HDLGGSEAVAGLVVGLFTLAALLARPFAGRLLD---------RFGRKRLLLIGLLI 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 340 sTCIMGANYTNDPMMIMCLMALAFFGNGFASITWS---LVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGF 416
Cdd:cd17489 71 -FALATLLYLLATSVALLLVLRLIHGIGWGAFTTAaatLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGF 149
|
170 180
....*....|....*....|....*...
gi 446175600 417 APALVYISAVALIGALSyILLVGDVKRV 444
Cdd:cd17489 150 AVLFIVAAVLALLALLL-VFLVKDPPPV 176
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
86-432 |
2.06e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 2.06e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 86 GGWFLDRVGSRVTyfIAIFGWSVATLFQ---GFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFY-- 160
Cdd:cd17370 54 SGYLSDRTGKRKP--LVILGYGLSALAKpllALAGSWQLVLLLRILERLGKGIRTPPRDALLADATPPSGRGKAFGLHra 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 161 --TSGQFVGLAFLTPLLIWIQEmlSWHWVFIVTGGIGIIWSLIWFKVYQPPRltkgiskaeldyirdggglvdgDAPVKK 238
Cdd:cd17370 132 ldTLGAVLGPLLAALLLYLLGG--NYRTIFLLAAIPALLALLILLFVVKEYP----------------------RPPKLR 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 239 EARQPLTAKDWKLVFHRKLIGVYLgqFAVASTLWFFLTwfpnYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADll 318
Cdd:cd17370 188 KKSKKTSLKKLPKAFWLYLLAVAL--FALGNFSFAFLI----LRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSD-- 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 319 vRKGfslgfaRKTPIICGLLISTCI-MGANYTNDPMMIMCLMALAFFGNG-FASITWSLVSSLAPMRLIGLTGGVFNFAG 396
Cdd:cd17370 260 -RIG------RKKLLILGYLSLALAyLGFALGSSLWLLLLGFILWGLYMGaQESIERAAVADLVPAELRGTAYGLFNTVV 332
|
330 340 350
....*....|....*....|....*....|....*.
gi 446175600 397 GLGGITVPLVVGYLAQGYGFAPALVYISAVALIGAL 432
Cdd:cd17370 333 GIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALL 368
|
|
| MFS_MCT11_13 |
cd17423 |
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ... |
92-317 |
2.67e-03 |
|
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340981 [Multi-domain] Cd Length: 383 Bit Score: 39.68 E-value: 2.67e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 92 RVGSRVTYFIAIFGWSVATLFQGFATGLMSL-IGLRAITGIFEAPAFPTNNRMVTSWFpEHERASAVGFYTSGQFVGLAF 170
Cdd:cd17423 64 RYGARPVVMLGGLLSSLGFLLASFATSLLHLyLCIGLLSGLGWALVFAPTMATVSRYF-SRRRSLATGLALTGVGLSSFA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 171 LTPLLIWIQEMLSWHWVFIVTGGIgIIWSLIWFKVYQPPRLtkgiskaeldyirdggglvDGDAPvkKEARQPLTAKDWK 250
Cdd:cd17423 143 LSPLFQLLLDTYAWRGALLLLSAL-SLHLVPCGALLRPLAL-------------------PGDPP--APPRSLSAAFGLS 200
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446175600 251 LVFHRKLigvylGQFAVASTLwFFLTWFPNYL-----TQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADL 317
Cdd:cd17423 201 LLTHRAF-----LRYALATTL-INTGYFIPYVhlvahARALGLGEYQAAFVVSVAAVADAVGRLFSGWLADL 266
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
282-438 |
3.01e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 39.45 E-value: 3.01e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 282 LTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADllvrkgfslGFARKTPIICGLLIST--CIMGANYTNDPMMIMCLM 359
Cdd:cd17324 25 IARDFGVSVAQAGLLVSAYALGYALGALLLGPLSD---------RIERRRLLLVLLLLFIlgNLLAALAPSFALLLLARA 95
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446175600 360 ALAFFGNGFASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:cd17324 96 LAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL 174
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
69-201 |
5.05e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.78 E-value: 5.05e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 69 GYVFSAFAWLYTLCQIPGGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFeAPAFPTNNRMVTSWF 148
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVF-SGYVPNATALIASQT 117
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446175600 149 PEHERASAVGFYTSGQFVGlAFLTPLL-IWIQEMLSWHWVFIVTGGIGIIWSLI 201
Cdd:cd17391 118 PKEKSGWALGTLSTGVVAG-TLIGPLLgGFLADLFGIRNVFFITGGLLFLAFLL 170
|
|
| MFS_YdiM_like |
cd17396 |
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator ... |
148-438 |
5.47e-03 |
|
Inner membrane transport protein YdiM and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily contains Escherichia coli inner membrane transport proteins YdiM and YdiN, which belong to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340954 [Multi-domain] Cd Length: 384 Bit Score: 38.87 E-value: 5.47e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 148 FPEHErASAV----GFYTSGQFVgLAFLTPLLIWiqEMLSWHWVFIVTGGIGIIWSLIWFKVYQPPRLtkgiskaeldyi 223
Cdd:cd17396 117 FPKAS-GSANilvkAFVSFGQFL-LPFIIAFLAA--NNLWYGWSFIVPAAVLVLNALLLLKLSFPPQT------------ 180
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 224 rdggglVDGDAPVKKEArqplTAKDWKLVFHRKLIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAgfMTTVPFLA 303
Cdd:cd17396 181 ------VTAANTKQKEI----PVKREKPKFLIEGIALILIGFTSTATFYLFSQWMPKYGSAVAGMGEAES--LKLISYYS 248
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 304 afVGVLLSGWVADLLVRKGFSLGFArktpIICGLLISTCIMGANYTNdPMMIMCLMALAFFG----NGFASITWSLVSSL 379
Cdd:cd17396 249 --MGSLVCVFITAVLLKRYVRPIWI----LVLYPIISLLALFVLYLV-PSPDVCILGAFVIGffaaGGVLQLGLTLMAEF 321
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*....
gi 446175600 380 APMRLIGLTGgVFNFAGGLGGITVPLVVGYLAQGYGFAPALVYISAVALIGALSYILLV 438
Cdd:cd17396 322 FPKGKGKVTG-IYMIASSLANFVIPLITGIIASAIGIAYIFLFDFGIALLGLLLAIFVF 379
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
257-437 |
5.52e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.75 E-value: 5.52e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 257 LIGVYLGQFAVASTLWFFLTWFPNYLTQEKGITALKAGFMTTVPFLAAFVGVLLSGWVADLlvrkgfslgFARKTPIICG 336
Cdd:cd17329 1 LWVLLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR---------FGRKPVMLAG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 337 LLISTC-IMGANYTNDPMMIMCLMALAFFGNG-FASITWSLVSSLAPMRLIGLTGGVFNFAGGLGGITVPLVVGYLAQGY 414
Cdd:cd17329 72 LLLRALgFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS 151
|
170 180
....*....|....*....|...
gi 446175600 415 GFAPALVYISAVALIGALSYILL 437
Cdd:cd17329 152 FRLLFLAAAVLFLLAALVLLFLL 174
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
86-203 |
9.83e-03 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 37.95 E-value: 9.83e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446175600 86 GGWFLDRVGSRVTYFIAIFGWSVATLFQGFATGLMSLIGLRAITGIFEAPAFPTNNRMVTSWFPEHERASAVGFYTSGQF 165
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGILFGLFWA 124
|
90 100 110
....*....|....*....|....*....|....*...
gi 446175600 166 VGLAFLTPLLIWIQemlSWHWVFIVTGGIGIIWSLIWF 203
Cdd:cd17317 125 LGYMLLALLAYLIR---DWRWLQLAISLPGLLFLLLLW 159
|
|
| |
