|
Name |
Accession |
Description |
Interval |
E-value |
| ASKHA_ATPase_ROK_Mlc |
cd24074 |
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies ... |
84-406 |
0e+00 |
|
ATPase-like domain of protein Mlc and similar proteins; Mlc, also called making large colonies protein, acts as a transcriptional repressor that regulates the expression of proteins that are part of the phosphotransferase system for sugar uptake. It regulates the expression of malT. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466924 [Multi-domain] Cd Length: 322 Bit Score: 519.56 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 84 AWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGV 163
Cdd:cd24074 1 GWQFLSIRIGRGYITLALRDLNGRLLAEERYPLPAKDNDPFLDRLLESISEFFSRHQKKLERLTAIAITLPGIIDPESGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 164 VHRMPYYeDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLV 243
Cdd:cd24074 81 VHRLPFY-DIKNLPLGEALEQHTGLPVYVQHDISAWTLAERFFGAAKGAKNIIQIVIDDDIGAGVITDGQLLHAGSSRLG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 244 EIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVG 323
Cdd:cd24074 160 ELGHTQIDPYGKRCYCGNHGCLETVASIPAILEQANQLLEQSPDSMLHGQPISIESLCQAALAGDPLAQDIIIQVGRHLG 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 324 RILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLLIRL 403
Cdd:cd24074 240 RILAILVNLFNPEKILIGSPLNNAAEILFPALSQSIRQQSLPAYSQHLQIESTKFYNDGTMPGAALIKDALYDGSLLLKL 319
|
...
gi 446147239 404 LQG 406
Cdd:cd24074 320 LQG 322
|
|
| ASKHA_ATPase_ROK_NagC |
cd24075 |
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as ... |
86-400 |
4.13e-102 |
|
ATPase-like domain of N-acetylglucosamine repressor (NagC) and similar proteins; NagC acts as a repressor of the nagEBACD operon involved in the uptake and degradation of the amino sugars, N-acetyl-D-glucosamine (GlcNAc) and glucosamine (GlcN). It acts both as an activator and a repressor for the transcription of the glmSU operon, encoding proteins necessary for the synthesis of GlcN (glmS) and the formation of UDP-GlcNAc (glmU). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466925 [Multi-domain] Cd Length: 315 Bit Score: 305.44 E-value: 4.13e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 86 HYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGVVH 165
Cdd:cd24075 2 HILAVRLGRHDLTLGLYDLSGELLAEHTVPLTALNQEALLSQLIEEIAQFLKSHRRKTQRLIAISITLPGLINPKTGVVH 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 166 RMPYYEdVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEI 245
Cdd:cd24075 82 YMPHIQ-VKSWPIVEELEQRFNVPCFIGNDIRSLALAEHYFGASKDCKDSILVRIHHGIGAGIIIDGKLFLGQNGNAGEI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 246 GHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRI 325
Cdd:cd24075 161 GHIQIEPLGERCHCGNFGCLETVASNAAIEQRVKKLLKQGYASQLTLQDCTIKDICQAALNGDQLAQDVIKRAGRYLGKV 240
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446147239 326 LAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALVKDAMYNGSLL 400
Cdd:cd24075 241 IAILINLLNPQKIIIAGEITQADKVLLPVIKKCIQSQALPDFRQELKIVASQLDHNSAIGAFALVKRALLEGGLL 315
|
|
| NagC |
COG1940 |
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate ... |
82-390 |
1.10e-83 |
|
Sugar kinase of the NBD/HSP70 family, may contain an N-terminal HTH domain [Carbohydrate transport and metabolism, Transcription];
Pssm-ID: 441543 [Multi-domain] Cd Length: 306 Bit Score: 257.90 E-value: 1.10e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 82 TEAWHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTE-ATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTE 160
Cdd:COG1940 2 PDAGYVIGIDIGGTKIKAALVDLDGEVLARERIPTPAGAgPEAVLEAIAELIEELLAEAGISRGRILGIGIGVPGPVDPE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 161 NGVVHRMPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSS 240
Cdd:COG1940 82 TGVVLNAPNLPGWRGVPLAELLEERLGLPVFVENDANAAALAEAWFGAGRGADNVVYLTLGTGIGGGIVINGKLLRGANG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 241 SLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNqsmssmlhGQPLTVDSLCQAAMQGDLLAKDIISGVGA 320
Cdd:COG1940 162 NAGEIGHMPVDPDGPLCGCGNRGCLETYASGPALLRRARELGG--------AEKLTAEELFAAARAGDPLALEVLDEAAR 233
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 321 HVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALV 390
Cdd:COG1940 234 YLGIGLANLINLLDPEVIVLGGGVSAAGDLLLEPIREALAKYALPPAREDPRIVPASLGDDAGLLGAAAL 303
|
|
| ASKHA_NBD_ROK_TM1224-like |
cd24059 |
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and ... |
86-388 |
4.30e-68 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima N-acetylglucosamine kinase (TM1224) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to N-acetylglucosamine kinase (Tm1224; EC 2.7.1.59) from Thermotoga maritima, which belongs to kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Tm1224 lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466909 [Multi-domain] Cd Length: 305 Bit Score: 217.84 E-value: 4.30e-68
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 86 HYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTE-ATPLLERIITHVDRFFtRHQQKLERLTSIAITLPGIIDTENGVV 164
Cdd:cd24059 2 YVIGVEIGRDLLSAVLCDLSGNILAREKYPLDEKEnPEEVLEKLYELIDRLL-EKENIKSKILGIGIGAPGPLDVEKGII 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 165 HRMPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVE 244
Cdd:cd24059 81 LNPPNFPGWENIPLVELLEEKFGIPVYLDNDANAAALAEKWYGKGKNYDNFIYILADEGIGAGIIINGKLYRGVDGYAGE 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 245 IGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHgqpltvdsLCQAAMQGDLLAKDIISGVGAHVGR 324
Cdd:cd24059 161 IGHTSIDINGPRCSCGNRGCLELYASIPAIEKKARSALGSGRSFQLD--------IVEALQKGDPIADEVIEEAAKYLGI 232
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446147239 325 ILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAA 388
Cdd:cd24059 233 GLVNLINLLNPEAIIIGGELIYLGERYLEPIEKEVNSRLFGRNAREVRILKSSLGEDAPLLGAA 296
|
|
| ASKHA_ATPase_ROK_CYANR |
cd24073 |
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; ... |
85-371 |
6.14e-66 |
|
ATPase-like domain of cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and similar proteins; CYANR acts as transcriptional repressor of cyclobis-(1-6)-alpha-nigerosyl (CNN) degrading enzymes. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466923 [Multi-domain] Cd Length: 304 Bit Score: 212.03 E-value: 6.14e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 85 WHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGVV 164
Cdd:cd24073 1 AYVVGVKLTEDRITAVLTDLRGNVLASHTLPLDSGDPEAVAEAIAEAVAELLAQAGLSPDRLLGIGVGLPGLVDAETGIC 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 165 HRMPYY--EDVkemPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSL 242
Cdd:cd24073 81 RWSPLLgwRDV---PLAELLEERLGLPVYVENDVNALALAEHWFGAGRGLDNFAVVTIGRGIGCGLVVDGRLYRGAHGGA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 243 VEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQsmssmlhGQPLTVDSLCQAAMQGDLLAKDIISGVGAHV 322
Cdd:cd24073 158 GEIGHTTVDPDGPPCRCGKRGCLEAYASDPAILRQAREAGLR-------GEPLTIEDLLAAARAGDPAARAILRRAGRAL 230
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 446147239 323 GRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNT 371
Cdd:cd24073 231 GLALANLVNLLDPELIIISGEGVRAGDLLFEPMREALRAHVFPGLASDL 279
|
|
| ASKHA_ATPase_ROK_BsXylR-like |
cd24076 |
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This ... |
85-388 |
8.88e-61 |
|
ATPase-like domain of Bacillus subtilis xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Bacillus subtilis xylose repressor (BsXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. BsXylR acts as transcriptional repressor of xylose-utilizing enzymes.
Pssm-ID: 466926 [Multi-domain] Cd Length: 303 Bit Score: 198.94 E-value: 8.88e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 85 WHYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEA-TPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGV 163
Cdd:cd24076 1 GAVIGVELGVDYITVVVTDLAGEVLWRREVPLPASDDpDEVLAQLAALIREALAAAPDSPLGILGIGVGVPGLVDSEDGV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 164 VHRMPY--YEDVkemPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHaGSSS 241
Cdd:cd24076 81 VLLAPNlgWRDV---PLRDLLEEALGVPVFVDNEANAAALAEKRFGAGRGVSDLVYLSAGVGIGAGIILDGELYR-GASG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 242 LV-EIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQsmssmlhGQPLTVDSLCQAAMQGDLLAKDIISGVGA 320
Cdd:cd24076 157 FAgEIGHMTVDPDGPPCSCGNRGCWETYASERALLRAAGRLGAG-------GEPLSLAELVEAARAGDPAALAALEEVGE 229
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446147239 321 HVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAA 388
Cdd:cd24076 230 YLGIGLANLVNTFNPELVVLGGALAPLGPWLLPPLRAEVARRALPAPARDVRIVVSRLGEDAAALGAA 297
|
|
| ROK |
pfam00480 |
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon ... |
88-392 |
8.96e-54 |
|
ROK family; This family, known as ROK (Repressor, ORF, Kinase) includes the xylose operon repressor, xylR, from Bacillus subtilis, Lactobacillus pentosus and Staphylococcus xylosus; N-acetylglucosamine repressor, nagC, from Escherichia coli; glucokinase from Streptomyces coelicolor; fructokinase from from Pediococcus pentosaceus, Streptococcus mutans and Zymomonas mobilis; allokinase and mlc from E. coli; and E. coli hypothetical proteins yajF and yhcI and the corresponding Haemophilus influenzae proteins. The repressor proteins (xylR and nagC) from this family possess an N-terminal region not present in the sugar kinases and which contains an helix-turn-helix DNA-binding motif.
Pssm-ID: 395384 [Multi-domain] Cd Length: 292 Bit Score: 180.23 E-value: 8.96e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 88 LSIRISRGEIFLALRDLSSKLVVEECLPLPlTEATPllERIITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGVVHRM 167
Cdd:pfam00480 1 IGIDIGGTKIAAALFDEEGEILARERVPTP-TTTTE--ETLVDAIAFFVDSAQRKFGELIAVGIGSPGLISPKYGYITNT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 168 PYYeDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGH 247
Cdd:pfam00480 78 PNI-GWDNFDLVEKLEERFNVPVFFENDANAAALAEAVFGASKDVQNVIYVTVGTGVGGGVISNGKLFTGRNGVAGEIGH 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 248 TQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNqsmssmlhgqPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILA 327
Cdd:pfam00480 157 IQLDPNGPKCGCGNHGCLETIASGRALEKRYQQKGE----------DLEGKDIIVLAEQGDEVAEEAVERLARYLAKAIA 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446147239 328 IMVNLFNPQKILIGSPLSkAADILFPAIADSIRQQALPAYSRNTV-VESTQFTNQGTMAGAA-LVKD 392
Cdd:pfam00480 227 NLINLFDPQAIVLGGGVS-NADGLLEAIRSLVKKYLNGYLPVPPViIVAASLGDNAGALGAAaLAKQ 292
|
|
| ASKHA_NBD_ROK_BsGLK-like |
cd24062 |
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; ... |
128-388 |
2.65e-49 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466912 [Multi-domain] Cd Length: 311 Bit Score: 169.01 E-value: 2.65e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 128 IITHVDRFFTRHQQKLERLTSIAITLPGIIDTENGVVhrmpyYEDV----KEMPLGDALERHTGVPVYIQHDISAWTMAE 203
Cdd:cd24062 44 IAESIQQLLEELGYSKEDLIGIGVGVPGPVDVETGTV-----EVAVnlgwKNFPLKDKLEALTGIPVVIDNDANAAALGE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 204 ALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPY-GKRCYCGNHGCLETIASVDSVLELTQLRL 282
Cdd:cd24062 119 MWKGAGQGAKDLVFITLGTGVGGGVIANGKIVHGANGAAGEIGHITVNPEgGAPCNCGKTGCLETVASATGIVRIAREEL 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 283 NQS-----MSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIAD 357
Cdd:cd24062 199 EEGkgssaLRILALGGELTAKDVFEAAKAGDELALAVVDTVARYLGLALANLANTLNPEKIVIGGGVSAAGEFLLSPVKE 278
|
250 260 270
....*....|....*....|....*....|.
gi 446147239 358 SIRQQALPAYSRNTVVESTQFTNQGTMAGAA 388
Cdd:cd24062 279 YFDRFTFPRVRQDTEIVLATLGNDAGVIGAA 309
|
|
| ASKHA_ATPase_ROK_Lmo0178-like |
cd24071 |
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily ... |
86-390 |
3.03e-49 |
|
ATPase-like domain of Listeria monocytogenes Lmo0178 and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Listeria monocytogenes Lmo0178 protein, which is a predicted transcription repressor belonging to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466921 [Multi-domain] Cd Length: 312 Bit Score: 169.00 E-value: 3.03e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 86 HYLSIRISRGEIFLALRDLSSKLV-VEECLPLPLTEATPLLERIITHVDRFFTRHQQKlERLTSIAITLPGIIDTENGVV 164
Cdd:cd24071 2 YIIGVKIEEGYLVLALTDLKGKILeKTRIPFDHETDPEKVIELIAENIKKLIKNKHVE-KKLLGIGIAVSGLVDSKKGIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 165 HRMPY--YEDVkemPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSL 242
Cdd:cd24071 81 IRSTIlgWENV---ELKKILKEKFKIPVFIDNDVNSFALAELWKGKGKGYSNFICVTVGAGIGSSLVIDGKLYTGNFGGA 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 243 VEIGHTQVDPYGKRCYCGNHGCLETIASVDS-VLELTQLRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAH 321
Cdd:cd24071 158 GEIGHMTIQPDGRKCYCGQKGCLEAYASFEAlVNEIKELTESYPLSLLKELEDFEIEKVREAAEEGDSVATELFKKAGEY 237
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446147239 322 VGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALV 390
Cdd:cd24071 238 LGIGIKNLINIFNPEAIIIGGEGLEFKDYFLPKIIEIAKENFFGKAGRNVIILVDSLGEDAWVLGAALL 306
|
|
| ASKHA_NBD_ROK_TmGLK-like |
cd24064 |
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; ... |
144-388 |
4.03e-44 |
|
nucleotide-binding domain (NBD) of Thermotoga maritima glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466914 [Multi-domain] Cd Length: 301 Bit Score: 155.35 E-value: 4.03e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 144 ERLTSIAITLPGIIDTENGVVHRMPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHN 223
Cdd:cd24064 54 MELLGIGIGSPGSIDRENGIVRFSPNFPDWRNFPLVPLIEERTGIKVFLENDANAFALGEWWFGNAKGSNHIIGLTLGTG 133
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 224 VGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSmLHGQPLTVDS--LC 301
Cdd:cd24064 134 VGSGVICHGQLLTGYDGIAAELGHVIVEPNGPICGCGNRGCVEAFASATAIIRYARESRKRYPDS-LAGESEKINAkhVF 212
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 302 QAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQ 381
Cdd:cd24064 213 DAARKNDPLATMVFRRVVDALAIAIGGFVHIFNPEIIIIGGGISRAGSFLLDPIREKTKKYVMLSFQDTYSIELSNLVED 292
|
....*..
gi 446147239 382 GTMAGAA 388
Cdd:cd24064 293 AGILGAA 299
|
|
| ASKHA_NBD_ROK_FnNanK-like |
cd24068 |
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and ... |
121-389 |
6.49e-44 |
|
nucleotide-binding domain (NBD) of Fusobacterium nucleatum N-acetylmannosamine kinase and similar proteins; The family includes Fusobacterium nucleatum N-acetylmannosamine kinase (NanK; EC 2.7.1.60) and beta-glucoside kinase (BglK; EC 2.7.1.85) from Klebsiella pneumoniae and Listeria innocua. NanK catalyzes the second step of the sialic acid catabolic pathway, transferring a phosphate group from adenosine 5'-triphosphate to the C6 position of N-acetylmannosamine to generate N-acetylmannosamine 6-phosphate. Unlike other NanK enzymes and ROK family members, F. nucleatum NanK does not have a conserved zinc-binding site. BglK catalyzes the ATP-dependent phosphorylation of cellobiose to produce cellobiose-6'-P. It may have a dual role of kinase and transcriptional regulator of the cellobiose-PTS operon. The subfamily belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466918 [Multi-domain] Cd Length: 294 Bit Score: 154.64 E-value: 6.49e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 121 ATPLLERIITHVDRFftrhqQKLERLTSIAITLPGIIDTENGVVHR----MPYYedvKEMPLGDALERHTGVPVYIQHDI 196
Cdd:cd24068 37 GDAILERLLEIIAEL-----KEKYDIEGIGISSAGQVDPKTGEVIYatdnLPGW---TGTNLKEELEERFGLPVAVENDV 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 197 SAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLE 276
Cdd:cd24068 109 NCAALAEKWLGAAKGLDDFLCLTLGTGIGGAIILDGRLYRGANGSAGELGHMVVDPGGRPCCCGGKGCLEQYASGTALVR 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 277 LTQLRLNQSmssmlhgqPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIA 356
Cdd:cd24068 189 RVAEALGEP--------GIDGREIFDLADAGDPLAKEVVEEFAEDLATGLANLVHIFDPEVIVIGGGISAQGELFLEELR 260
|
250 260 270
....*....|....*....|....*....|...
gi 446147239 357 DSIRQQALPAYSRNTVVESTQFTNQGTMAGAAL 389
Cdd:cd24068 261 EELRKLLMPPLLDATKIEPAKLGNDAGLLGAAY 293
|
|
| ASKHA_ATPase_ROK |
cd23763 |
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family ... |
88-390 |
1.30e-42 |
|
ATPase-like domain of the ROK (Repressor, ORF, Kinase) domain family; The ROK family corresponds to a group of proteins including sugar kinases, transcriptional repressors, and yet uncharacterized open reading frames. ROK family sugar kinases phosphorylate a range of structurally distinct hexoses including the key carbon source D-glucose, various glucose epimers, and several acetylated hexosamines. The sugar kinases include N-acetyl-D-glucosamine kinase (NAGK; EC 2.7.1.59), polyphosphate glucokinase (PPGK; EC 2.7.1.63/EC 2.7.1.2), glucokinase (GLK; EC 2.7.1.2), fructokinase (FRK; EC 2.7.1.4), hexokinase (HK; EC 2.7.1.1), D-allose kinase (AlsK; EC 2.7.1.55), bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE; EC 3.2.1.183/EC 2.7.1.60), N-acetylmannosamine kinase (NanK; EC 2.7.1.60), beta-glucoside kinase (BglK; EC 2.7.1.85), and N-acetylglucosamine kinase (EC 2.7.1.59). The family also contains the repressor proteins, such as N-acetylglucosamine repressor (NagC), xylose repressor (XylR), cyclobis-(1-6)-alpha-nigerosyl repressor (CYANR) and protein Mlc. ROK kinases harbor a conserved N-terminal ATP binding motif of sequence DxGxT, while ROK repressors possess a N-terminal extension that contains a canonical helix-turn-helix DNA binding motif. The ROK family proteins belong to the ASKHA (Acetate and Sugar Kinases/Hsc70/Actin) superfamily of phosphotransferases, all members of which share a common characteristic five-stranded beta sheet occurring in both the N- and C-terminal domains.
Pssm-ID: 466849 [Multi-domain] Cd Length: 239 Bit Score: 149.54 E-value: 1.30e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 88 LSIRISRGEIFLALRDLSSKLVVEECLPLPLTE-ATPLLERIITHVDRFFTRHQQKlERLTSIAITLPGIIDTENGVVHR 166
Cdd:cd23763 1 IGIDIGGTKIRAALVDLDGEILARERVPTPAEEgPEAVLDRIAELIEELLAEAGVR-ERILGIGIGVPGPVDPETGIVLF 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 167 MPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIG 246
Cdd:cd23763 80 APNLPWWKNVPLRELLEERLGLPVVVENDANAAALGEAWFGAGRGVRNFVYITLGTGIGGGIIIDGKLYRGANGAAGEIG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 247 HTQVdpygkrcycgnhgcletiasvdsvleltqlrlnqsmssmlhgqpltvdslcqaamqgdllakdiISGVGAHVGRIL 326
Cdd:cd23763 160 HITV----------------------------------------------------------------LEEAARYLGIGL 175
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446147239 327 AIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQQALPAYSRNTVVESTQFTNQGTMAGAALV 390
Cdd:cd23763 176 ANLINLLNPELIVLGGGVAEAGDLLLEPIREAVRRRALPPLRRRVRIVPSELGDDAGLLGAAAL 239
|
|
| ASKHA_ATPase_ROK_YphH-like |
cd24072 |
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily ... |
86-360 |
1.45e-42 |
|
ATPase-like domain of Escherichia coli protein YphH and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Escherichia coli protein YphH that belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466922 [Multi-domain] Cd Length: 308 Bit Score: 151.41 E-value: 1.45e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 86 HYLSIRISRGEIFLALRDLSSKLVVEEcLPLPLTEATP--LLERIITHVDRfftRHQQKLERLTSIAITLPGIIDTENGV 163
Cdd:cd24072 2 WVLGIVVSPNSLRAQVGNACGELLGEF-EYRVITLETPeaLIDEIIDCIDR---LLKLWKDRVKGIALAIQGLVDSHKGV 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 164 VHRMPYYEDVkEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLV 243
Cdd:cd24072 78 SLWSPGAPWR-NIEIKYLLEERYGIPVFVENDCNMLALAEKWQGELRQSRDFCVINLDYGIGSAIVIDNKLYIGASSGSG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 244 EIGHTQVDPYGKRCYCGNHGCLETIASV-------DSVLELTQLRLNQSMSSMLHgqpltvdsLCQAAMQGDLLAKDIIS 316
Cdd:cd24072 157 EIGHTKVNPDGARCDCGRRGCLETVASNsalkrnaRVTLKLGPVSADPEKLTMEQ--------LIEALEEGEPIATQIFD 228
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446147239 317 GVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIR 360
Cdd:cd24072 229 RAANAIGRSLANILNLLNPEQVLLYGRGCRAGDLLLPAIRRAIA 272
|
|
| ASKHA_ATPase_ROK_SaXylR-like |
cd24077 |
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This ... |
86-390 |
2.02e-37 |
|
ATPase-like domain of Staphylococcus aureus xylose repressor (XylR) and similar proteins; This subfamily includes a group of uncharacterized proteins similar to Staphylococcus aureus xylose repressor (SaXylR), which belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. SaXylR acts as a transcriptional repressor of xylose-utilizing enzymes. It lacks the cysteine-rich zinc-binding motif, which presents in other family members.
Pssm-ID: 466927 [Multi-domain] Cd Length: 295 Bit Score: 137.29 E-value: 2.02e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 86 HYLSIRISRGEIFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKLERLTSIAITLPGIIDtENGVVH 165
Cdd:cd24077 2 YSIGIDLGYNYISLMLTYLDGEIISSKQIKLLDISFENILEILKSIIQELISQAPKTPYGLVGIGIGIHGIVD-ENEIIF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 166 rMPYYeDVKEMPLGDALERHTGVPVYIQHD--ISAwtMAEALFgaSRGARDVIQVVIDHNVGAGVITDGHLLH-----AG 238
Cdd:cd24077 81 -TPYY-DLEDIDLKEKLEEKFNVPVYLENEanLSA--LAERTF--SEDYDNLISISIHSGIGAGIIINNQLYRgyngfAG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 239 ssslvEIGHTQVDPYGKRCYCGNHGCLETIASVDSVLEltqlRLNQSMSSmlhgQPLTVDSLCQAAMQGDLLAKDIISGV 318
Cdd:cd24077 155 -----EIGHMIIVPNGKPCPCGNKGCLEQYASEKALLK----ELSEKKGL----ETLTFDDLIQLYNEGDPEALELIDQF 221
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446147239 319 GAHVGRILAIMVNLFNPQKILIGSPLSKAadilFPAIADSIRQQaLPAYSRNTV-VESTQFTNQGTMAGAALV 390
Cdd:cd24077 222 IKYLAIGINNIINTFNPEIIIINSSLINE----IPELLEKIKEQ-LSSSFNKYVeILISTLGKNATLLGGAAV 289
|
|
| ASKHA_NBD_ROK_SgGLK-like |
cd24061 |
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; ... |
118-388 |
1.43e-33 |
|
nucleotide-binding domain (NBD) of Streptomyces griseus glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466911 [Multi-domain] Cd Length: 306 Bit Score: 127.08 E-value: 1.43e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 118 LTEATP-----LLERIITHVDRFFTRHQqklerLTSIAITLPGIIDTENGVVHRMPYYeDVKEMPLGDALERHTGVPVYI 192
Cdd:cd24061 26 ERVPTPptadgIVDAIVEAVEELREGHD-----VSAVGVAAAGFVDADRATVLFAPNI-AWRNEPLKDLLEARIGLPVVI 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 193 QHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASVD 272
Cdd:cd24061 100 ENDANAAAWAEYRFGAGRGTDDMVMITVGTGLGGGIVIGGKLLRGAFGIAGEFGHIRVVPDGLLCGCGSRGCWEQYASGR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 273 SVLELTQLRLN------QSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSK 346
Cdd:cd24061 180 ALVRYAKEAANatpegaAVLLADGSVDGITGKHISEAARAGDPVALDALRELARWLGAGLASLAALLDPELFVIGGGVSD 259
|
250 260 270 280
....*....|....*....|....*....|....*....|....
gi 446147239 347 AADILFPAIADSIRqQALPAYSRNTVVE--STQFTNQGTMAGAA 388
Cdd:cd24061 260 AGDLLLDPIREAFE-RWLPGRGWRPIPRlrTAQLGNDAGLIGAA 302
|
|
| ASKHA_NBD_ROK_TtHK-like |
cd24065 |
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; ... |
114-390 |
2.39e-33 |
|
nucleotide-binding domain (NBD) of Thermus thermophilus hexokinase (HK) and similar proteins; HK (EC 2.7.1.1) possesses the ability to transfer an inorganic phosphate group from ATP to a substrate. It catalyzes the ATP-dependent phosphorylation of aldo- and keto-hexose sugars to the hexose-6-phosphate (H6P). Thermus thermophilus HK possesses significant enzymatic activity against glucose and mannose. However, it shows little catalytic capacity for galactose and fructose. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466915 [Multi-domain] Cd Length: 289 Bit Score: 126.29 E-value: 2.39e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 114 LPLPLTEATPLLERIITHVDRfftrHQQKLERLTSIAITLPGIIDTENGVVHRMPYYEDVKEMPLGDALERHTGVPVYIQ 193
Cdd:cd24065 28 VPTPREGGEAVLDALARAVEA----LQAEAPGVEAVGLGVPGPLDFRRGRVRFAPNIPGLTDFPIRRGLAERLGLPVVLE 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 194 HDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASVDS 273
Cdd:cd24065 104 NDANAAALAEHHYGAARGTESSVYVTISTGIGGGLVLGGRVLRGRHGQAGEIGHTTVLPGGPMCGCGLVGCLEALASGRA 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 274 VleltqlrlnQSMSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFP 353
Cdd:cd24065 184 L---------ARDASFAYGRPMSTAELFELAQQGEPKALRIVEQAAAHLGIGLANLQKALDPEVFVLGGGVAQVGDYYLL 254
|
250 260 270
....*....|....*....|....*....|....*....
gi 446147239 354 AIADSIRQ--QALPAysrnTVVESTQFTNQGTMAGAALV 390
Cdd:cd24065 255 PVQEAARRytEGWHA----PPLRLAHLGTDAGVIGAALA 289
|
|
| ASKHA_NBD_ROK_ApGLK-like |
cd24063 |
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; ... |
87-389 |
1.97e-29 |
|
nucleotide-binding domain (NBD) of Aeropyrum pernix glucokinase (GLK) and similar proteins; Glucokinase (EC 2.7.1.2), also called glucose kinase, acts as an ATP-dependent kinase that phosphorylates glucose using ATP as a donor to give glucose-6-phosphate and ADP. It is highly specific for glucose. Glucokinases are found in invertebrates and microorganisms. They belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466913 [Multi-domain] Cd Length: 308 Bit Score: 115.90 E-value: 1.97e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 87 YLSIRISRGEIFLALRDLSSKLVVEECLPLPLTE-ATPLLERIITHVDRFFTrhQQKLERLTSIAITLPGIIDTENGVVH 165
Cdd:cd24063 2 YVAVDIGGTWIRAGLVDEDGRILLKIRQPTPKTGdPGTVSEQVLGLIETLLS--KAGKDSIEGIGVSSAGPLDLRKGTIV 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 166 RMPYYEDvKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEI 245
Cdd:cd24063 80 NSPNIKG-KEIPLVEPLKEEFNIPVALLNDAVAAALGEHLFGAGRGTSNLVYITISTGIGGGVIVDGRLLLGKNGNAAEV 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 246 GHTQVDP-YGKRCYCGNHGCLETIASVDSVLELTQLRL-NQSMSSMLH-----GQPLTVDSLCQAAMQGDLLAKDIISGV 318
Cdd:cd24063 159 GHLVVDTeSGLKCGCGGYGHWEAFASGRGIPRFAREWAeGFSSRTSLKlrnpgGEGITAKEVFSAARKGDPLALKIIEKL 238
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446147239 319 GAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIADSIRQqaLPAYSRNTVVESTQF-TNQGTMAGAAL 389
Cdd:cd24063 239 ARYNGRGIANVINAYDPELIVIGGSVFNNNKDILDPLIEYLEK--NPAISKGPEIVLSELgDDVGLIGALAL 308
|
|
| ASKHA_NBD_ROK_GNE |
cd24060 |
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase ... |
145-375 |
3.75e-26 |
|
nucleotide-binding domain (NBD) of bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase (GNE) and similar proteins; GNE (EC 3.2.1.183/EC 2.7.1.60), also called UDP-GlcNAc-2-epimerase/ManAc kinase, is a bi-functional enzyme that plays a key role in sialic acid biosynthesis. It regulates and initiates biosynthesis of N-acetylneuraminic acid (NeuAc), a precursor of sialic acids. It plays an essential role in early development and required for normal sialylation in hematopoietic cells. Sialylation is implicated in cell adhesion, signal transduction, tumorigenicity and metastatic behavior of malignant cells. GNE is the only human protein that contains a kinase domain belonging to the ROK (repressor, ORF, kinase) family. Mutations of the GNE protein cause sialurea or autosomal recessive inclusion body myopathy/Nonaka myopathy.
Pssm-ID: 466910 [Multi-domain] Cd Length: 305 Bit Score: 107.12 E-value: 3.75e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 145 RLTSIAITLPGIIDTENGVV-HRMPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHN 223
Cdd:cd24060 59 RILGVGISTGGRVNPREGIVlHSTKLIQEWSSVDLRTPISDALHLPVWVDNDGNCAALAERKFGHGKGVENFVTVITGTG 138
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 224 VGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIASvDSVLELTQLRLNQSMSSMLHG------QPLTV 297
Cdd:cd24060 139 IGGGIILNHELIHGSSFCAAELGHIVVSLDGPDCMCGSHGCVEAYAS-GMALQREAKKLHDEDLLLVEGmsvtndEEVTA 217
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446147239 298 DSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLskaADILFPAIADSIRQQALPAYSRNTVVES 375
Cdd:cd24060 218 KHLIQAAKLGNAKAQKILRTAGTALGLGIVNILHTLNPSLVILSGVL---ASHYENIVKDVIAQRALPSVQNVDVVVS 292
|
|
| ASKHA_NBD_ROK_AlsK |
cd24070 |
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1. ... |
124-341 |
1.43e-20 |
|
nucleotide-binding domain (NBD) of D-allose kinase (AlsK) and similar proteins; AlsK (EC 2.7.1.55), also called allokinase, catalyzes the phosphorylation of D-allose to D-allose 6-phosphate. It has also low level glucokinase activity in vitro. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466920 [Multi-domain] Cd Length: 293 Bit Score: 91.07 E-value: 1.43e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 124 LLERIITHVDRFFTRHQQKLErltSIAITLPGIIDTENGVVHRMPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAE 203
Cdd:cd24070 41 PVEVLADLIREYIEEAGLKPA---AIVIGVPGTVDKDRRTVISTPNIPGLDGVNLADILENKLGIPVILERDVNLLLLYD 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 204 ALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLETIAsvdSVLELTQLRLN 283
Cdd:cd24070 118 MRAGNLDDEGVVLGFYIGTGIGNAILINGKPLRGKNGVAGELGHIPVYGNGKPCGCGNTGCLETYA---SGRALEEIAEE 194
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 446147239 284 qsmssmlHGQPltVDSLCQAAMQGDllAKDIISGVgAHVGRILAIMVNLFNPQKILIG 341
Cdd:cd24070 195 -------HYPD--TPILDIFVDHGD--EPELDEFV-EDLALAIATEINILDPDAVILG 240
|
|
| ASKHA_NBD_ROK_NAGK |
cd24057 |
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; ... |
148-390 |
1.76e-20 |
|
nucleotide-binding domain (NBD) of N-acetyl-D-glucosamine kinase (NAGK) and similar proteins; NAGK (EC 2.7.1.59), also called GlcNAc kinase, catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466907 [Multi-domain] Cd Length: 298 Bit Score: 90.75 E-value: 1.76e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 148 SIAITLPGIIDTENG--VVHRMPYyedVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVG 225
Cdd:cd24057 59 PVGIGIPGVIDPEDGtlITANIPA---AKGRPLRADLSARLGRPVRIDNDANCFALSEAWDGAGRGYPSVFGLILGTGVG 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 226 AGVITDGHLLHAGSSSLVEIGHT------QVDPYG---KRCYCGNHGCLETIASVDSVleltqlrlnQSMSSMLHGQPLT 296
Cdd:cd24057 136 GGLVVNGRLVGGRSGIAGEWGHGplpadaLLLGYDlpvLRCGCGQTGCLETYLSGRGL---------ERLYAHLYGEELD 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 297 VDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSKAADILfPAIADSIRQQALPAYsRNTVVEST 376
Cdd:cd24057 207 APEIIAAWAAGDPQAVAHVDRWLDLLAGCLANILTALDPDVVVLGGGLSNFPALI-AELPAALPAHLLSGA-RTPRIVPA 284
|
250
....*....|....
gi 446147239 377 QFTNQGTMAGAALV 390
Cdd:cd24057 285 RHGDAGGVRGAAFL 298
|
|
| ASKHA_NBD_ROK_EcFRK-like |
cd24066 |
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; ... |
125-346 |
2.85e-20 |
|
nucleotide-binding domain (NBD) of Escherichia coli fructokinase (FRK) and similar proteins; Escherichia coli FRK (EC 2.7.1.4), also called D-fructose kinase, manno(fructo)kinase, or MAK, catalyzes the phosphorylation of fructose to fructose-6-phosphate. It has also low level glucokinase activity in vitro. It is not able to phosphorylate D-ribose, D-mannitol, D-sorbitol, inositol, and L-threonine. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466916 [Multi-domain] Cd Length: 294 Bit Score: 90.34 E-value: 2.85e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 125 LERIITHVDRFftrhQQKLERLTSIAITLPGIIDTENGVV--------HRMPYYEDVKEMplgdaLERhtgvPVYIQHDI 196
Cdd:cd24066 39 LDAIADLVEEA----EEELGAPATVGIGTPGSISPRTGLVknanstwlNGKPLKADLEAR-----LGR----PVRIENDA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 197 SAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPY------GKRCYCGNHGCLETIAS 270
Cdd:cd24066 106 NCFALSEATDGAGAGAGVVFGVILGTGVGGGIVVNGRVLTGANGIAGEWGHNPLPWPdedelpGPPCYCGKRGCVETFLS 185
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446147239 271 vDSVLELTQLRlnqsmssmLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFNPQKILIGSPLSK 346
Cdd:cd24066 186 -GPALERDYAR--------LTGKTLSAEEIVALARAGDAAAVATLDRFLDRLGRALANVINILDPDVIVLGGGLSN 252
|
|
| ASKHA_NBD_ROK-like |
cd24152 |
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This ... |
149-387 |
8.13e-20 |
|
nucleotide-binding domain (NBD) of an uncharacterized subgroup of the ROK family; This subfamily is composed of uncharacterized proteins belonging to the the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this subfamily lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466988 [Multi-domain] Cd Length: 286 Bit Score: 88.78 E-value: 8.13e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 149 IAITLPGIIDTENGVVHRMPYYEDVKEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGV 228
Cdd:cd24152 57 IAISAPGVIDPETGIIYGGGALPYLKGFNLKEELEERCNLPVSIENDAKCAALAELWLGSLKGIKNGAVIVLGTGIGGAI 136
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 229 ITDGHLLH-----AGssslvEIGHTQVDPYGKRCYCGNHGCletiaSVDSVLELtqlrlnqsMSSMLHGQPLTVDSLCQA 303
Cdd:cd24152 137 IIDGKLYRgshffAG-----EFSYLLTDDDDKDLLFFSGLA-----SMFGLVKR--------YNKAKGLEPLDGEEIFEK 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 304 AMQGDLLAKDIISgvgAHVGRILAIMVNL---FNPQKILIGSPLSkAADILFPAIADSIRQ--QALPAYSRNTVVESTQF 378
Cdd:cd24152 199 YAKGDEAAKKILD---EYIRNLAKLIYNIqyiLDPEVIVIGGGIS-EQPLFIEDLKKEVNEilANRPGSIPKPEIKACKF 274
|
....*....
gi 446147239 379 TNQGTMAGA 387
Cdd:cd24152 275 GNDANLLGA 283
|
|
| ASKHA_NBD_ROK_EcNanK-like |
cd24069 |
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar ... |
174-373 |
2.37e-19 |
|
nucleotide-binding domain (NBD) of Escherichia coli N-acetylmannosamine kinase and similar proteins; N-acetylmannosamine kinase (NanK; EC 2.7.1.60), also called ManNAc kinase, or N-acetyl-D-mannosamine kinase, catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P. It has also low level glucokinase activity in vitro. This subfamily also contains Brucella melitensis bifunctional enzyme NanE/NanK (EC 5.1.3.9/EC 2.7.1.60), which also converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P). Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466919 [Multi-domain] Cd Length: 283 Bit Score: 87.34 E-value: 2.37e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 174 KEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAGSSSLVEIGHTQVDPY 253
Cdd:cd24069 80 SGFPLADALQQLLGVPVVLLNDAQAAAWGEYQAGDGEGVGNLVFITVSTGVGGGLVLNGQLLTGPNGLAGHIGHTLADPP 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 254 GKRCYCGNHGCLETIASVDSVLELtqlrlnqsmSSMLHGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLF 333
Cdd:cd24069 160 GPVCGCGRRGCVEAIASGTAIAAA---------ASEILGEPVDAKDVFERARSGDEEAARLIDRAARALADLIADLKATL 230
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 446147239 334 NPQKILIGSPLSkAADILFPAIAdsIRQQALPAYSRNTVV 373
Cdd:cd24069 231 DLDCVVIGGSVG-LAEGFLERVE--QYLADEPAIFRVSLE 267
|
|
| PRK05082 |
PRK05082 |
N-acetylmannosamine kinase; Provisional |
174-341 |
7.99e-13 |
|
N-acetylmannosamine kinase; Provisional
Pssm-ID: 235338 [Multi-domain] Cd Length: 291 Bit Score: 68.40 E-value: 7.99e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 174 KEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGaRDVIQVVIDHNVGAGVITDGHLlHAGSSSLV-EIGHTQVDP 252
Cdd:PRK05082 84 LHFPLVQTLEQLTDLPTIALNDAQAAAWAEYQALPDDI-RNMVFITVSTGVGGGIVLNGKL-LTGPGGLAgHIGHTLADP 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 253 YGKRCYCGNHGCLETIASVDSVLELTQLRLNQSMSSMLHgqpltvdslcQAAMQGDLLAKDIISGVGAHVGRILAIMVNL 332
Cdd:PRK05082 162 HGPVCGCGRRGCVEAIASGRAIAAAAQGWLAGCDAKTIF----------ERAGQGDEQAQALINRSAQAIARLIADLKAT 231
|
....*....
gi 446147239 333 FNPQKILIG 341
Cdd:PRK05082 232 LDCQCVVLG 240
|
|
| PRK13310 |
PRK13310 |
N-acetyl-D-glucosamine kinase; Provisional |
97-388 |
5.60e-12 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 183967 [Multi-domain] Cd Length: 303 Bit Score: 66.17 E-value: 5.60e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 97 IFLALRDLSSKLVVEECLPLPLTEATPLLERIITHVDRFFTRHQQKlerlTSIAITLPGIIDTENGVVhrmpYYEDV--- 173
Cdd:PRK13310 12 IELGVFNEKLELQWEERVPTPRDSYDAFLDAVCELVAEADQRFGCK----GSVGIGIPGMPETEDGTL----YAANVpaa 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 174 KEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLlHAGSSSLV-EIGHTQVdP 252
Cdd:PRK13310 84 SGKPLRADLSARLGRDVRLDNDANCFALSEAWDDEFTQYPLVMGLILGTGVGGGLVFNGKP-ISGRSYITgEFGHMRL-P 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 253 YGK-----------RCYCGNHGCLETIASVdsvleltqlRLNQSMSSMLHGQPLTVDSLCQAAMQGDLLAKdiisgvgAH 321
Cdd:PRK13310 162 VDAltllgwdaplrRCGCGQKGCIENYLSG---------RGFEWLYQHYYGEPLQAPEIIALYYQGDEQAV-------AH 225
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446147239 322 VGR---ILAIMV-NLF---NPQKILIGSPLSKaadilFPAIADSIrQQALPAY----SRNTVVESTQFTNQGTMAGAA 388
Cdd:PRK13310 226 VERyldLLAICLgNILtivDPHLVVLGGGLSN-----FDAIYEQL-PKRLPRHllpvARVPRIEKARHGDAGGVRGAA 297
|
|
| PRK09557 |
PRK09557 |
fructokinase; Reviewed |
114-345 |
8.99e-12 |
|
fructokinase; Reviewed
Pssm-ID: 236565 [Multi-domain] Cd Length: 301 Bit Score: 65.43 E-value: 8.99e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 114 LPLPLTEATPLLERIITHVDRFFTRHQQKlerlTSIAITLPGIIDTENGVVHRM--------PYYEDvkempLGDALERh 185
Cdd:PRK09557 29 LPTPRDDYQQTIEAIATLVDMAEQATGQR----GTVGVGIPGSISPYTGLVKNAnstwlngqPLDKD-----LSARLNR- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 186 tgvPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLlHAGSSSLV-EIGHTQV-----DPYGKR--- 256
Cdd:PRK09557 99 ---EVRLANDANCLAVSEAVDGAAAGKQTVFAVIIGTGCGAGVAINGRV-HIGGNGIAgEWGHNPLpwmdeDELRYRnev 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 257 -CYCGNHGCLET-IASVDSVLELTQLRlnqsmssmlhGQPLTVDSLCQAAMQGDLLAKDIISGVGAHVGRILAIMVNLFN 334
Cdd:PRK09557 175 pCYCGKQGCIETfISGTGFATDYRRLS----------GKALKGSEIIRLVEEGDPVAELAFRRYEDRLAKSLAHVINILD 244
|
250
....*....|.
gi 446147239 335 PQKILIGSPLS 345
Cdd:PRK09557 245 PDVIVLGGGMS 255
|
|
| PRK09698 |
PRK09698 |
D-allose kinase; Provisional |
123-379 |
2.62e-11 |
|
D-allose kinase; Provisional
Pssm-ID: 182034 [Multi-domain] Cd Length: 302 Bit Score: 63.85 E-value: 2.62e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 123 PLLERIITHVDRFFTRHQQKLERltsIAITLPGIIDTENGVVHRMPYYEDVKE--MPLGDALERHTGVPVYIQHDIS--- 197
Cdd:PRK09698 42 DLVSGLGEMIDEYLRRFNARCHG---IVMGFPALVSKDRRTVISTPNLPLTALdlYDLADKLENTLNCPVFFSRDVNlql 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 198 AWtmaealfgasrgarDVIQVVIDHNV----------GAGVITDGHLLHAGSSSLVEIGHTQVDPYGKRCYCGNHGCLET 267
Cdd:PRK09698 119 LW--------------DVKENNLTQQLvlgaylgtgmGFAVWMNGAPWTGAHGVAGELGHIPLGDMTQHCGCGNPGCLET 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 268 IAS-VDSVLELTQLRLNQSMSSML--HGQPLTVDSLCqaamqgDLLAKDIisgvgahvgrilAIMVNLFNPQKILIGSPL 344
Cdd:PRK09698 185 NCSgMALRRWYEQQPRDYPLSDLFvhAGDHPFIQSLL------ENLARAI------------ATSINLFDPDAIILGGGV 246
|
250 260 270
....*....|....*....|....*....|....*....
gi 446147239 345 SKAADILFPAIADSIRQQALPAYSRNTV----VESTQFT 379
Cdd:PRK09698 247 MDMPAFPRETLIAMIQKYLRKPLPYEVVrfiyASSSDFN 285
|
|
| ASKHA_NBD_ROK_PPGK |
cd24058 |
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK ... |
149-371 |
3.68e-08 |
|
nucleotide-binding domain (NBD) of polyphosphate glucokinase (PPGK) and similar proteins; PPGK (EC 2.7.1.63/EC 2.7.1.2), also called poly(P)/ATP-glucomannokinase (GMK), poly(P) glucokinase, ATP-dependent glucokinase, or polyphosphate--glucose phosphotransferase, catalyzes the phosphorylation of glucose using polyphosphate or ATP as the phosphoryl donor. Polyphosphate, rather than ATP, seems to be the major phosphate donor for the enzyme in Mycobacterium tuberculosis. GTP, UTP and CTP can replace ATP as phosphoryl donor. PPGK belongs to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities. Members of this family lack the cysteine-rich zinc-binding motif, which presents in other ROK families.
Pssm-ID: 466908 [Multi-domain] Cd Length: 239 Bit Score: 53.73 E-value: 3.68e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 149 IAITLPGIIdtENGVVHRMPYYEDV-KEMPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVV-IDHNVGA 226
Cdd:cd24058 58 VGVGFPGVV--RRGVVRTAANLDKSwIGFDAAKLLSKRLGRPVRVLNDADAAGLAEMKGGAGKGEKGVVLVLtLGTGIGS 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 227 GVITDGHLLHAgssslVEIGHTQVDpygkrcycgnHGCLETIASvDSVLELTQLRLNQSmssmlhgqpltvdslcqaamq 306
Cdd:cd24058 136 ALFVDGHLVPN-----TELGHLEIR----------GKDAEERAS-LGVRAREDLGWKRW--------------------- 178
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446147239 307 gdllakdiisgvGAHVGRILAIMVNLFNPQKILIGSPLSKAADILFPAIadSIRQQALPAYSRNT 371
Cdd:cd24058 179 ------------AKRVNKYLQYLERLFNPDLFIIGGGNSKKADKFLPLL--DVKTPVVPAVLRND 229
|
|
| ASKHA_NBD_ROK_BsFRK-like |
cd24067 |
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; ... |
177-270 |
8.84e-08 |
|
nucleotide-binding domain (NBD) of Bacillus subtilis fructokinase (FRK) and similar proteins; Bacillus subtilis FRK (EC 2.7.1.4), also called glucomannan utilization protein E, catalyzes the phosphorylation of fructose to fructose-6-P. It seems to be involved in the degradation of glucomannan. Members of this subfamily belong to the kinase (ROK) family, a group of proteins that have sugar kinase and/or transcriptional repressor activities.
Pssm-ID: 466917 [Multi-domain] Cd Length: 285 Bit Score: 53.32 E-value: 8.84e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 177 PLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAGVITDGHLLHAgsssLV--EIGHTQV---- 250
Cdd:cd24067 86 DILGALKRAFPVPVGFDTDVNAAALAEYRWGAAKGLDSLAYITVGTGIGVGLVVNGKPVHG----LLhpEMGHIRVprhp 161
|
90 100
....*....|....*....|....
gi 446147239 251 --DPYGKRC-YcgnHG-CLETIAS 270
Cdd:cd24067 162 ddDGFPGVCpF---HGdCLEGLAS 182
|
|
| PRK13311 |
PRK13311 |
N-acetyl-D-glucosamine kinase; Provisional |
148-270 |
5.39e-04 |
|
N-acetyl-D-glucosamine kinase; Provisional
Pssm-ID: 106271 [Multi-domain] Cd Length: 256 Bit Score: 41.55 E-value: 5.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446147239 148 SIAITLPGIIDTENGVVHRMPYYEDVKEmPLGDALERHTGVPVYIQHDISAWTMAEALFGASRGARDVIQVVIDHNVGAG 227
Cdd:PRK13311 59 SVGIGIPGLPNADDGTVFTANVPSAMGQ-PLQADLSRLIQREVRIDNDANCFALSEAWDPEFRTYPTVLGLILGTGVGGG 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446147239 228 VITDGHLLHAGSSSLVEIGHTQV-----DPYGKR-----CYCGNHGCLETIAS 270
Cdd:PRK13311 138 LIVNGSIVSGRNHITGEFGHFRLpvdalDILGADiprvpCGCGHRGCIENYIS 190
|
|
| Fe_dep_repress |
pfam01325 |
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria ... |
20-60 |
3.06e-03 |
|
Iron dependent repressor, N-terminal DNA binding domain; This family includes the Diphtheria toxin repressor. DNA binding is through a helix-turn-helix motif.
Pssm-ID: 396062 [Multi-domain] Cd Length: 57 Bit Score: 35.81 E-value: 3.06e-03
10 20 30 40
....*....|....*....|....*....|....*....|.
gi 446147239 20 AVYRLIDQLGPVSRIDLSRLAQLAPASITKIVREMLEAHLV 60
Cdd:pfam01325 9 TIYTLSEEKGVVKTKDLAERLNVSPSTVSEMLKKLEKMGYV 49
|
|
| |
