|
Name |
Accession |
Description |
Interval |
E-value |
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
14-447 |
8.44e-140 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 409.89 E-value: 8.44e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:PRK10504 13 WIVAFGFFMQSLDTTIVNTALPSMAQSLGESPLHMHMVIVSYVLTVAVMLPASGWLADRVGVRNIFFTAIVLFTLGSLFC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:PRK10504 93 ALSGTLNELLLARVLQGVGGAMMVPVGRLTVMKIVPREQYMAAMTFVTLPGQVGPLLGPALGGLLVEYASWHWIFLINIP 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 IGVAGILYARKYMPNFTTPRRKFDMTGFFLFGLSLVLFSsgMELFGEK---IVATWIAsAIIFCSIVLLLAYIRHARRHP 250
Cdd:PRK10504 173 VGIIGAIATLMLMPNYTMQTRRFDLSGFLLLAVGMATLT--LALDGSKglgLSPLAIA-GLVAVGVVALLLYLLHARNNN 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 251 TPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKT 330
Cdd:PRK10504 250 RALFSLKLFRTRTFSLGLAGSFAGRIGSGMLPFMTPVFLQIGLGFSPFHAGLMMIPMVLGSMGMKRIVVQVVNRFGYRRV 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 331 LVGITvfIGLMIAQFSFQSPAMPIWMLVLP--LFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVA 408
Cdd:PRK10504 330 LVATT--LGLALVSLLFMLVALLGWYYLLPfvLFLQGMVNSTRFSSMNTLTLKDLPDNLASSGNSLLSMIMQLSMSIGVT 407
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446124217 409 ISAAVLRIY------EGFAGTSTVeqFHYTFITMGAITIVSALMF 447
Cdd:PRK10504 408 IAGLLLGLFgqqhvsVDSGATHTV--FMYTYLCMALIIALPALIF 450
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
16-451 |
1.33e-102 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 311.43 E-value: 1.33e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 16 AAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACAL 95
Cdd:cd17503 1 LLLGAFMAILDTTIVNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 96 SSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIG 175
Cdd:cd17503 81 APNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 176 VAGILYArkympnfttprrkfdmtgfflfglslvlfssgmelfgekivatwiasaiifcsivlllayirharrhptPLIS 255
Cdd:cd17503 161 ILALLLA---------------------------------------------------------------------PLLD 171
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 256 LSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGIT 335
Cdd:cd17503 172 LRLFKDRNFTLGLLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 336 VFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLR 415
Cdd:cd17503 252 LLLALGTLLLAFLTPDTSLWLIILPLFIRGLGMGLVFMPLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLATLLT 331
|
410 420 430 440
....*....|....*....|....*....|....*....|....*....
gi 446124217 416 IYEGFAGT-------------STVEQFHYTFITMGAITIVSALMFMLLR 451
Cdd:cd17503 332 NRTQFHHSrlsellaqqvqkqALIIAFNDAFLVSAILLLVGLLLALFLR 380
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
18-435 |
7.43e-72 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 235.35 E-value: 7.43e-72
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 18 MAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSS 97
Cdd:TIGR00711 9 LGTFMAVLDSTIVNVAIPTIAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 98 SLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVA 177
Cdd:TIGR00711 89 NLELMIIFRVIQGFGGGPLIPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGWIIENYHWRWIFLINVPIGII 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 178 GILYARKYMPNFTTP-RRKFDMTGFFLFGLSLVLFSSGMELFGEKivaTWIASAII----FCSIVLLLAYIRHARRHPTP 252
Cdd:TIGR00711 169 VVVVAFFILPRDKPAaSENFDFLGLLLLSVGLGSLLYGLSEGPER---GWFDSNEIlilsITGLVAIIAFVVWELTDDNP 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 253 LISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLV 332
Cdd:TIGR00711 246 LVDLRLFKYRNFTIGCVYMSLLGLGLYGSFYLLPLYLQQVLGYTALQAGLHILPVGLAPMLSSPIAGRMGDKIDPRKLVT 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 333 GITVFIGLMIAQFSFQ-SPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISA 411
Cdd:TIGR00711 326 IGLILYAVGFYWRAFTfTPDTPFLAIALPQFIRGFGMGCFFMPLTTIALSGLPPHKIARGSSLSNFTRQLGGSIGTALIT 405
|
410 420
....*....|....*....|....
gi 446124217 412 AVLRIYegfagtstvEQFHYTFIT 435
Cdd:TIGR00711 406 TILTNR---------TQFHHSQLT 420
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
17-451 |
1.47e-55 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 189.31 E-value: 1.47e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 17 AMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALS 96
Cdd:cd17321 2 LLAVFLAALDVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 97 SSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGV 176
Cdd:cd17321 82 PSLAFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 177 AGILYArkympnfttprrkfdmtgfflfglslvlfssgmelfgekivatwiasaiifcsivlllayirharrhptplisl 256
Cdd:cd17321 162 VALLLA-------------------------------------------------------------------------- 167
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 257 slfktRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITV 336
Cdd:cd17321 168 -----RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPRLVLVAGLL 242
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 337 FIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVL-- 414
Cdd:cd17321 243 LTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLGALLta 322
|
410 420 430 440
....*....|....*....|....*....|....*....|....*...
gi 446124217 415 -----------RIYEGFAGTSTVEQFHYTFITMGAITIVSALMFMLLR 451
Cdd:cd17321 323 glsanlgdsgvAALLSAAAAAFAAGFHLAFLVAAALALLAALLALLLP 370
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
3-405 |
1.27e-40 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 148.97 E-value: 1.27e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 3 SKKARSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVA 82
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 83 VSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWA 162
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 163 SWHWIFLINIPIGVAGILYARKYMPNfttprrkfdmtgfflfglslvlfssgmelfgekivatwiasaiifcsivlllay 242
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPE------------------------------------------------------ 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 243 IRHARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVL 322
Cdd:COG2814 188 SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLA 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 323 RRLGYRKTLVGITVFIGLMIAQFSFqspAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLS 402
Cdd:COG2814 268 DRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLG 344
|
...
gi 446124217 403 ISL 405
Cdd:COG2814 345 GPL 347
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
18-412 |
9.27e-38 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 140.78 E-value: 9.27e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 18 MAFFMQALDATILNTALPAIAHSLNRSPLaMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSS 97
Cdd:cd17502 3 LALFLAALDQTIVATALPTIVAEFGGLSL-VSWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAP 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 98 SLSELVIFRVVQGVGGAMMMPVARLALLRAYP---RSELLPVLNFVTMpglVGPILGPVLGGVLVTWASWHWIFLINIPI 174
Cdd:cd17502 82 NMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPpreRGKYQGYIGAVFG---IASVAGPLIGGAFTDHLSWRWCFYINLPI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 175 GvagilyarkympnfttprrkfdmtgfflfGLSLVLFSSgmelfgekivaTWIASAIIFCSIVLLLAYIrharrhptpli 254
Cdd:cd17502 159 G-----------------------------GLALALLRT-----------ILLSSIFGFLFGGALFGLI----------- 187
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 255 slslfktrtfsvgiagnlatrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGI 334
Cdd:cd17502 188 ----------------------------YYLPLYFQLVLGDSATKSGVRLLPLIIGLVIGSIISGALISKTGRYKPLIVI 239
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446124217 335 TVFIGLM-IAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAA 412
Cdd:cd17502 240 GTILMSVgAGLLTTLTLDTSKWLLIGYLILLGLGLGIGFQQPLVAVQNAVPPADVGVATATNTFFRSLGGTLGVAITDV 318
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-289 |
3.47e-34 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 129.93 E-value: 3.47e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 1 MTSKKARSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFM 80
Cdd:COG0477 4 TDAAPTRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 81 VAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVT 160
Cdd:COG0477 84 IGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 161 WASWHWIFLINIPIGVAGILYARKYM--PNFTTPRRKFDMTGFFLFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVL 238
Cdd:COG0477 164 ALGWRWIFLINAPLGLLALVLRLRLPesRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLL 243
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|.
gi 446124217 239 LLAYIRHARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLML 289
Cdd:COG0477 244 ALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLALL 294
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
17-451 |
3.41e-31 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 123.46 E-value: 3.41e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 17 AMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALS 96
Cdd:cd17504 2 ALAALAVMLVETMLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 97 SSLSELVIFRVVQGVGGAmMMPVArLALLRAYPRSELLPV-LNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIG 175
Cdd:cd17504 82 PNLPVLIAGRALQGIGGA-VFPLA-FALVREEFPPERVPVaQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 176 VAGILYArkympnfttprrkfdmtgfflfglslvlfssgmelfgekivatwiasaiifcsivlllayirharrhptPLIS 255
Cdd:cd17504 160 VLLAALV---------------------------------------------------------------------PLID 170
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 256 LSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQ----VGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTL 331
Cdd:cd17504 171 LRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVL 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 332 VGITVFIGLMIAQFSFQSPAmpIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISA 411
Cdd:cd17504 251 LIGLVISAVGLLLLALLHSS--LWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAG 328
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 446124217 412 AVL---RIYEGFAGTSTVEQFHYTFITMGAITIVSALMFMLLR 451
Cdd:cd17504 329 AILttyTVSITSGGVPTEGAYVLAFLIGAALALAALLLSLLIP 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
17-406 |
1.78e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 109.82 E-value: 1.78e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 17 AMAFFMQALDATILNTALP-AIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACAL 95
Cdd:pfam07690 2 FLAAFLAALGRSLLGPALPlLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 96 SSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIG 175
Cdd:pfam07690 82 ASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILS 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 176 VAGILYARKYMPNFTTPRRKfdmtgfFLFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVLLLAYIrharrhptplis 255
Cdd:pfam07690 162 LLAAVLLLLPRPPPESKRPK------PAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYL------------ 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 256 lslfktrtfsvgiagnlatrlgtgcvpflmpLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGIT 335
Cdd:pfam07690 224 -------------------------------PLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLAL 272
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446124217 336 VFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLG 406
Cdd:pfam07690 273 LLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| PRK14995 |
PRK14995 |
SmvA family efflux MFS transporter; |
24-409 |
1.93e-26 |
|
SmvA family efflux MFS transporter;
Pssm-ID: 184957 [Multi-domain] Cd Length: 495 Bit Score: 111.74 E-value: 1.93e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 24 ALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELV 103
Cdd:PRK14995 19 AIDATVLHVAAPTLSMTLGASGNELLWIIDIYSLVMAGMVLPMGALGDRIGFKRLLMLGGTLFGLASLAAAFSPTASWLI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 104 IFRVVQGVGGAMMMPVA----RLALLRAYPRSELLPVLNFVtmpGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGI 179
Cdd:PRK14995 99 ATRALLAIGAAMIVPATlagiRATFTEEKQRNMALGVWAAV---GSGGAAFGPLVGGILLEHFYWGSVFLINVPIVLVVM 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 180 LYARKYMPNFTTPRR---KFDMTGFFLFGLSLVLFSSGMELFGEkiVATWIASAIIFCSIVLLLAYIRHARRHPTPLISL 256
Cdd:PRK14995 176 GLTARYVPRQAGRRDqplNLGHALMLIVAILLLVYSAKTALKGF--LSLWVTSLTLLTGALLLGLFIRTQLAASRPMIDM 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 257 SLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKT-----L 331
Cdd:PRK14995 254 RLFTHRIILSGVVMAMTAMITLVGFELLMAQELQFVHGLSPLEAGMFMLPVMVASGFSGPIAGILVSRLGLRLVatggmA 333
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446124217 332 VGITVFIGLMIAQFSFQSPAMPIWMLvlplfILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAI 409
Cdd:PRK14995 334 LSALSFYGLAMTDFSTQQWQAWGLMA-----LLGFSAASALLASTSAIMAAAPPEKAAAAGAIETMAYELGAGLGIAI 406
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
12-411 |
2.44e-26 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 109.97 E-value: 2.44e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 12 LPWIAAMAFFMQaLDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSL 91
Cdd:cd17320 1 LLLLALLVALGP-LAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 92 ACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLIN 171
Cdd:cd17320 80 LCALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFL 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 172 IPIGVAGILYARKYMPNFTTPRRKFDMTGFFLFGLSLVLFSSGmelFGEKIVATWIASAIIFcsivlllAYIrharrhpt 251
Cdd:cd17320 160 ALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNRR---FLGYALALGLSFAGLF-------AYL-------- 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 252 plislslfktrtfsvgiagnlatrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTL 331
Cdd:cd17320 222 -------------------------------AAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLL 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 332 -VGITVFIGLMIAQFSFQSP-AMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDnASSGNSVLAVTQQLSISLGVAI 409
Cdd:cd17320 271 rLGLLLLLAAALVLLLAALLgGLSLWPLVAPLFLIFFGFGLIFPNATSLALEPFPHV-AGTASALLGFLQFLIGALAGAL 349
|
..
gi 446124217 410 SA 411
Cdd:cd17320 350 VG 351
|
|
| MFS_effux_SdrM |
NF040895 |
multidrug efflux MFS transporter SdrM; |
21-447 |
2.13e-21 |
|
multidrug efflux MFS transporter SdrM;
Pssm-ID: 468830 [Multi-domain] Cd Length: 441 Bit Score: 96.19 E-value: 2.13e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 21 FMQALDATILNTALPAIAHSLN-RSPLAMQSAIisYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSL 99
Cdd:NF040895 16 FMAAIETSIISLALPTIKEDLNaGSSISLVFTV--YFIALVIANPIVGELLSRFKIIYITILGLLLFIIGSLMSGLSETF 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 100 SELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGI 179
Cdd:NF040895 94 TMLIISRIIQGLGAGVMMSLSQIVPKLAFEIPLRYKIMGIVGSVWGISSIIGPLLGGGILEFATWHWLFFINIPIAIIAI 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 180 LYARKYMpNF----TTPRRKFDMTGFFLFGLSLVLFssgmeLFGEKIVATWIASAIIFC-SIVLLLAYIRHARRHPTPLI 254
Cdd:NF040895 174 ILVIFTF-HFpeeeTTSKTKFDVKGLTLFYIFIALL-----MFAVLNQGHLWLNIISFIlAIVVFFLLFKVEKKVKNPFL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 255 SLSLFKtRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGyRKTLVgI 334
Cdd:NF040895 248 PVKEFN-KSIILVFFTDFLIAMMLMGYNLYIPIYLQEHLGLSPLQSGLVIFPLSVAWLILNFNLAKIEAKLT-RKGLY-I 324
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 335 TVFIGLMIAQFS-FQSPAMPIwMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAV 413
Cdd:NF040895 325 GAFTLLIVCSILiLFGLKLPL-LIAFALILAGLSFGTVYTKDSVIVQEETSPSNMKKMMSFYTLTKNLGSSIGSTIMGYI 403
|
410 420 430
....*....|....*....|....*....|....
gi 446124217 414 LRIYEGFAGTSTVEQFHYTFITMGAITIVSALMF 447
Cdd:NF040895 404 YALQVGLFGLSIQNILALIIIILIILIILWSTLY 437
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
14-378 |
4.68e-21 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 94.56 E-value: 4.68e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:cd17474 2 YAVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWaSWHWIFLINIP 173
Cdd:cd17474 82 GLSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLAAI-SWRYPFFLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 IGVAGILYARKYMPNfttPRRKFDMTGFFLFGLSLVLFSSGMelfgekivaTWIASAIIFCSIVLLLAYIrharrhptpl 253
Cdd:cd17474 161 LIPVAFLAILFLLPE---PKEKAKSSSATKLRDLKKALRGRG---------LLTFLVSAFLYFFLYFAFL---------- 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 254 islslfktrtfsvgiagnlatrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVL-RRLGYRKTLV 332
Cdd:cd17474 219 -----------------------------TYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLkKRFGARRILV 269
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 446124217 333 -GITVFIGLMIAQFSFQSpampIWMLVLPLFILGMAMSTQFTAMNTI 378
Cdd:cd17474 270 iGLLLYALSLLLLGFVPS----LALLLIAIVLFGLGLGLNLPLLTTL 312
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
14-453 |
3.05e-20 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 91.86 E-value: 3.05e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:COG2271 13 ALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInip 173
Cdd:COG2271 93 GFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLI--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 IGVAGILYArkympnfttprrkfdmtgfflfglslvlfssgmelfgekIVATWIASAIIFCSIVLLLAYIrharrhptpl 253
Cdd:COG2271 170 LGLPGLLLA---------------------------------------LLRFWLLALAYFLVYFALYGFL---------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 254 islslfktrtfsvgiagnlatrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVG 333
Cdd:COG2271 201 -----------------------------TWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 334 ITVFIGLMIAqFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAV 413
Cdd:COG2271 252 AIGLLLAALA-LLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYL 330
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446124217 414 LRIYegfagtstveQFHYTFITMGAITIVSALMFMLLRVK 453
Cdd:COG2271 331 LDAT----------GYQAAFLLLAALALLAALLALLLLRE 360
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
15-413 |
5.84e-19 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 88.09 E-value: 5.84e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACA 94
Cdd:cd17476 2 TISGAQLLNQAGLGSVIVILPIIGDSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 95 LSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLP-VLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInip 173
Cdd:cd17476 82 FSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNiVFSLFGATAPLGFALGGVFGGLFAQLAWWPWIFWF--- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 igvagilyarkympnfttprrkFDMTGFFLFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVLLLAYIRharrhptpl 253
Cdd:cd17476 159 ----------------------LAILAAIVAVAAIFWTSPSFIAVLLAVFLGWASFGIWVFYATQYFQNVR--------- 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 254 islslfktrtfsvgiagnlatrlgtgcvpflmplmlqvgfGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLgyRKTLVG 333
Cdd:cd17476 208 ----------------------------------------GYSPLLTSARFIPMAIGGVLAAITVGFLIARL--PPSYIM 245
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 334 ITVFIGLMIAQ--FSFQSPAMPIWMLVLPLFIL---GMAMStqFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVA 408
Cdd:cd17476 246 AISMVAFLVGPilFATMPVHQTYWAQAFPAMIVapfGMDFS--FPAATIIASNAVPREYQGLAGSLVNTVVNYGISIGLG 323
|
....*
gi 446124217 409 ISAAV 413
Cdd:cd17476 324 IAGTV 328
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
17-451 |
3.70e-18 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 85.71 E-value: 3.70e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 17 AMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALS 96
Cdd:cd17325 2 SLALFLDMLGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 97 SSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGV 176
Cdd:cd17325 82 TSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 177 AGILYARKYMPNFTTPRRKFDMTGFFLFGLSLVLFSSGmelfgeKIVATWIASAIIFCSIVLLLAYIrharrhptplisl 256
Cdd:cd17325 162 LALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRDR------RLLALFLAIFVLAFAFGALEPFL------------- 222
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 257 slfktrtfsvgiagnlatrlgtgcvpflmPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITV 336
Cdd:cd17325 223 -----------------------------PLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL 273
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 337 FIGLMIAQFSFQSpamPIWMLVLPLFILGMAMSTQFTAMNTItLADLTDdnASSGNSVLAVtQQLSISLGVAISAAVLri 416
Cdd:cd17325 274 LSAVALLLLPLAT---SFWLLLLLLALLGLGLGLVFPATLAL-LADIVP--PEGRGTAMGL-FNTAFSLGMVLGPLLG-- 344
|
410 420 430
....*....|....*....|....*....|....*
gi 446124217 417 yeGFAgtSTVEQFHYTFITMGAITIVSALMFMLLR 451
Cdd:cd17325 345 --GFL--YDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-177 |
7.83e-17 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 76.92 E-value: 7.83e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 52 IISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRS 131
Cdd:TIGR00880 4 LAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 446124217 132 ELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVA 177
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALA 129
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-180 |
3.59e-16 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 79.96 E-value: 3.59e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 33 ALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVG 112
Cdd:PRK11102 13 ALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLA 92
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446124217 113 GAMMMPVARlALLR-AYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLInipIGVAGIL 180
Cdd:PRK11102 93 AAAASVVIN-ALMRdMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWV---LALAAIL 157
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
14-196 |
4.48e-16 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 79.74 E-value: 4.48e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:TIGR00710 8 LLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:TIGR00710 88 ALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLSL 167
|
170 180
....*....|....*....|...
gi 446124217 174 IGVAGILYARKYMPNfTTPRRKF 196
Cdd:TIGR00710 168 AGILLSALIFFILPE-TLPYEAR 189
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
14-453 |
4.91e-16 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 79.54 E-value: 4.91e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 IGVAGILYARKYMPNfttprrkfdmTGFFLFGLSLVLFSSGMELFGEKivATWIASAIIFCSIVLLLAYIrharrhptpl 253
Cdd:COG2223 168 LLLVVAVLAWLFLRD----------PPAGAAAAAKASLRDQLEALRDP--RFWLLSLLYFGTFGSFIGFS---------- 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 254 islslfktrtfsvgiagnlatrlgtgcvpFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVG 333
Cdd:COG2223 226 -----------------------------SWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 334 ITVFIGLMIAQFSFqsPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAV 413
Cdd:COG2223 277 VFALMALGLLLLAL--ALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354
|
410 420 430 440
....*....|....*....|....*....|....*....|
gi 446124217 414 LRIYEGFAgtstveqfhYTFITMGAITIVSALMFMLLRVK 453
Cdd:COG2223 355 LDATGSYT---------AAFLVFAVLALVALVLTLLLYRR 385
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
33-451 |
1.46e-15 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 78.00 E-value: 1.46e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 33 ALPAIA-HSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGV 111
Cdd:cd17473 21 ALPAIAqHFVPNSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGI 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 112 GGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWaSWHWIFLInipigvagilyarkympnftt 191
Cdd:cd17473 101 GVAGIMTLATALIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGALAEI-GWRAPFLV--------------------- 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 192 prrkfdmtgfflFGLSLVLFssgmelfgekivatwiasaiifcsiVLLLAYIRHARRHPTPLISLSLFKTRTFSVG---- 267
Cdd:cd17473 159 ------------YLLALPVL-------------------------ILVLLFLPEPARKSKSAASPGAATAAALPWKrvlp 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 268 -IAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVgitVFIGLMIAQFS 346
Cdd:cd17473 202 iYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLA---IGFALMALGFL 278
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 347 FQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLavtqQLSISLGVAISAAVLRIYEGFAGTstv 426
Cdd:cd17473 279 LLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIV----TSAFFLGQFLSPLVLGPLVNLTGG--- 351
|
410 420
....*....|....*....|....*
gi 446124217 427 eqFHYTFITMGAITIVSALMFMLLR 451
Cdd:cd17473 352 --LSGAFLILGVLALVLAIVLLLLR 374
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
14-414 |
6.02e-15 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 76.05 E-value: 6.02e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:cd17324 2 LALALAAFAIGTTEYVIQGLLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:cd17324 82 ALAPSFALLLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 IGVAGILYARKYMPNFTTPRRKfdmtgfflfglSLVLFSSGMELFGEKIVatWIASAIIFCsivlllayirharrhptpl 253
Cdd:cd17324 162 LALLAALLLWRLLPSLPPKKPG-----------SLGLLSSLLLLLRNPRL--RLAYLITFL------------------- 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 254 islslfktrtfsvGIAGNLATrlgtgcVPFLMPLMLQVGFGYPALIAGCMMApTALGSIIAKSTVTQVLRRLGYRKTLVG 333
Cdd:cd17324 210 -------------LFGGFFAL------YTYLAPFLTDVPGFSSSAIIGLLLL-FGVAGVVGSPLAGRLADRGGRRALLIA 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 334 itvFIGLMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTItLADLTDDNASSGNSVLAVTQQLSISLGVAISAAV 413
Cdd:cd17324 270 ---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTR-VLRLAPEARGLASSLYLAAYNLGGALGAALGGLV 345
|
.
gi 446124217 414 L 414
Cdd:cd17324 346 L 346
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
14-175 |
7.09e-14 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 72.99 E-value: 7.09e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIP 173
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
..
gi 446124217 174 IG 175
Cdd:cd17323 162 IS 163
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
14-182 |
9.94e-14 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 72.22 E-value: 9.94e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFM---QALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGS 90
Cdd:cd17319 3 RIIPLLFLAyviNYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 91 LACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:cd17319 83 ALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFII 162
|
170
....*....|..
gi 446124217 171 nipIGVAGILYA 182
Cdd:cd17319 163 ---EGLLGLLLA 171
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
15-415 |
1.77e-13 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 72.27 E-value: 1.77e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQsAIISYTLTVAMLIPVSGWLADRFGtRRVFMVAVSLFTL-GSLAC 93
Cdd:cd06179 2 ALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTW-ISTAWSLAQAVLGPIVGRLSDLFG-RRWFFIGGNLLGVvGSIVA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAM--MMPVARLALLRAYPRSELLPVLNFVTMPGLVgpiLGPVLGGVLV--TWASWHWIFL 169
Cdd:cd06179 80 GTAKSVNMLIGGQALIGIGAGTqgLGAAVASELVPNKYRGLVQGVVNLVASPGSA---LGPLIAGALVeaNAAGWRWIFY 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 170 INIPI-GVAGILYARKYMP-NFTTPR--------RKFDMTGFFLFGLSLVLFSSGMELFGEkiVATWIASAII------F 233
Cdd:cd06179 157 INAIFnALALILLFFFYHPpPRPQLHgsstrqklKRLDWVGLFLLIAGLVLFLLGLSWGGN--PYPWSSAHVIaplvigG 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 234 CSIVLLLAYIRHARRHPtPLISLSLFKTRTFS-----VGIAGNLATRLGTgcvpfLMPLMLQVGFGYPALIAGCMMAPTA 308
Cdd:cd06179 235 VLLIAFGLYEWKGTKDG-LLPPRLLFRGRNFAlilivAFVEGMIFYSLNI-----FWPQQISLLFTTDPLKAGLYQLPFG 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 309 LGSIIAKSTVTQVLRRLGYRKTLVGI-----TVFIGLMiAQFSFQSPAMPIWMLVLPLFILGmamSTQFTAMNTITLAdL 383
Cdd:cd06179 309 LGTLFGAILAGLLLTKIKHIKWQLVAgfvlfTAFLALL-ALITPDNKALAIAFSVLAGIGIG---GPLVLAIVIVQLS-V 383
|
410 420 430
....*....|....*....|....*....|..
gi 446124217 384 TDDNASSGNSVLAVTQQLSISLGVAISAAVLR 415
Cdd:cd06179 384 PPEDIGTASGLLGSARALGGAVGTAIFTSILS 415
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
16-422 |
7.24e-13 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 69.76 E-value: 7.24e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 16 AAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACAL 95
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 96 SSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTW--ASWHWIFLINIP 173
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSlgFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 174 IGVAGILYARKYMPNFTTPRRKFDMTGFFLFGLSLVlfssgmelfgekivatwiasaiifcsivlllayirharrhptpl 253
Cdd:cd06174 161 LALLAAILLLLVVPDPPESARAKNEEASSKSVLKLL-------------------------------------------- 196
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 254 isLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVG 333
Cdd:cd06174 197 --KRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLL 274
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 334 ITVFIglMIAQFSFQSPAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAV 413
Cdd:cd06174 275 IGLLL--MALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFL 352
|
....*....
gi 446124217 414 LRIYEGFAG 422
Cdd:cd06174 353 LAATFGLTG 361
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
28-450 |
1.92e-12 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 68.41 E-value: 1.92e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 28 TILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMV-----AVSLFTLGSLACALSSSLSEL 102
Cdd:cd06173 16 WIFTVALPWLVLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILadllrALLAAVLALLALLGSLSLWLL 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 103 VIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLIN-IPIGVAGILY 181
Cdd:cd06173 96 LVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINaLSFLLSALLL 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 182 ARKYMPNFTTPRRKFDMTGFFLFGLSLVLFSSGmelfgeKIVATWIASAIIFCSIVLLLAyirharrhptplislslfkt 261
Cdd:cd06173 176 LFIRRPPPAAPGESSSLLLRDLREGLRYLRRSP------LLRLLLLALALFALLGGALTV-------------------- 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 262 rtfsvgiagnlatrlgtgcvpfLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLM 341
Cdd:cd06173 230 ----------------------LLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLA 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 342 IAQFSFQSpamPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLriyeGFA 421
Cdd:cd06173 288 LLVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA----DAL 360
|
410 420
....*....|....*....|....*....
gi 446124217 422 GTSTVeqfhytFITMGAITIVSALMFMLL 450
Cdd:cd06173 361 GLSAV------FLLAGALLLLAALLLLLL 383
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
28-183 |
3.47e-12 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 68.01 E-value: 3.47e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 28 TILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRV 107
Cdd:PRK11652 25 TIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 108 VQG----VGGAMMMPVARlallRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWH--WIFLINIPIGVAGILY 181
Cdd:PRK11652 105 IQGlgtgVGGVMARTLPR----DLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRacYLFLLLLGAGVTFSMA 180
|
..
gi 446124217 182 AR 183
Cdd:PRK11652 181 RW 182
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
15-170 |
4.54e-12 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 67.38 E-value: 4.54e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSaIISYTLTVAMLIP-VSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:TIGR00895 21 LSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGF-LFSAGLIGMAFGAlFFGPLADRIGRRRVLLWSILLFSVFTLLC 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:TIGR00895 100 ALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFGWRSLFYV 176
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
7-397 |
7.95e-12 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 66.80 E-value: 7.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 7 RSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLF 86
Cdd:COG0738 4 KNYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLM 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 87 TLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSE--LLPVLNFVTMpglVGPILGPVLGGVLVTW--- 161
Cdd:COG0738 84 ALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPETAasRLNLLHAFFS---LGALLGPLLGGLLILLgls 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 162 ASWHWIFLIN-IPIGVAGILYARKYMPNFTTprrkfdmtgfflfglslvlfssgmelfgekivatwiasaiifcsivlll 240
Cdd:COG0738 161 LSWHLPYLILaVLLLLLALLFLRSKLPEIEE------------------------------------------------- 191
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 241 ayiRHARRHPTPLISLSLFKTRTFSVGIAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQ 320
Cdd:COG0738 192 ---EEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGF 268
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446124217 321 VLRRLGYRKTLVGITVFIGLMIAQFSFQSPAmpiWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAV 397
Cdd:COG0738 269 LLKRFGPVRLLRLSALLAAVGLLLALLAPGP---WLALIGLALVGLGLSLMFPTIFSLALDGLGKRTAAAVSAVLIM 342
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
25-170 |
2.10e-11 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 65.30 E-value: 2.10e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 25 LDATILNTALPAIAHSLNRSPlAMQSAIISYTLtVAMLIP--VSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSEL 102
Cdd:cd17365 13 FDLAVMGFVAPALAQDWGLSP-AQLGPVGSAAL-FGMAIGalLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQL 90
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446124217 103 VIFRVVQGVGGAMMMPVArLALLRAYPRSELLPVLNFVTMPGL-VGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:cd17365 91 ALLRFLTGLGLGAAMPNA-ITLVSEYAPARRRSLAVTLMFCGYpLGAALGGFLAAALIPAFGWRSVFLL 158
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
15-183 |
9.14e-11 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 63.00 E-value: 9.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIP--VSGWLADRFGTRRVFMVAVSLFTLGSLA 92
Cdd:cd17316 3 LAGLGWFFDAYDFFLIGFVAPVLAAEFSLGLSLLQTGLLFAAGFLGRPIGalLFGYLGDRIGRKKALILTLLLFGLATLL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 93 CALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWAS----WHWIF 168
Cdd:cd17316 83 IGLLPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVASLLIPLLSgdwgWRILF 162
|
170
....*....|....*
gi 446124217 169 LINIPIGVAGILYAR 183
Cdd:cd17316 163 LIGALPALLALLLRR 177
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
18-180 |
1.20e-10 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 63.00 E-value: 1.20e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 18 MAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSS 97
Cdd:cd17489 3 LANFFFFLSFYLLLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 98 SLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVA 177
Cdd:cd17489 83 SVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALL 162
|
...
gi 446124217 178 GIL 180
Cdd:cd17489 163 ALL 165
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
32-168 |
7.51e-10 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 60.42 E-value: 7.51e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 32 TALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGV 111
Cdd:PRK10473 24 VGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGI 103
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446124217 112 GGAMMMPVArLALLR----AYPRSELLPVLNFVTmpgLVGPILGPVLGGVLVTWASWHWIF 168
Cdd:PRK10473 104 GAGCCYVVA-FAILRdtldDRRRAKVLSLLNGIT---CIIPVLAPVLGHLIMLKFPWQSLF 160
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
33-195 |
7.62e-10 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 60.72 E-value: 7.62e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 33 ALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVG 112
Cdd:PRK15402 35 GMLAVVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 113 GAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGILYARKYMPNFTTP 192
Cdd:PRK15402 115 LCFIGAVGYAAIQESFEEADAIKITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGR 194
|
...
gi 446124217 193 RRK 195
Cdd:PRK15402 195 VGE 197
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
14-177 |
4.43e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.40 E-value: 4.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSP----LAMQSAIISYTLtvamLIPVSGWLADRFGTRRVFMVAVSLFTLG 89
Cdd:cd17328 2 AVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDslagLLQTVFIISYMV----LSPIFGYLGDRYNRKWILAVGILIWSAA 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 90 SLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWA-SWHWIF 168
Cdd:cd17328 78 TLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAF 157
|
....*....
gi 446124217 169 LINIPIGVA 177
Cdd:cd17328 158 RVTGVLGVL 166
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
15-123 |
6.68e-09 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 57.58 E-value: 6.68e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACA 94
Cdd:cd17359 5 VAALGGLLFGYDTGVINGALPFLQTDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSA 84
|
90 100 110
....*....|....*....|....*....|.
gi 446124217 95 LSSSLSELVIFRVVQG--VGGAMMMPVARLA 123
Cdd:cd17359 85 FSPNFTIFIIARIIGGlaVGGASALVPMYIA 115
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
2-182 |
9.55e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 57.20 E-value: 9.55e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 2 TSKKARSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLnrspLAMQSAIISYTLTVAMLI-----PVSGWLADRFGTR 76
Cdd:cd17325 190 SGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAEL----GGLSPAQIGLLFGAQGLAsalsqPPAGKLSDRIGRK 265
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 77 RVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGG 156
Cdd:cd17325 266 PLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGG 345
|
170 180
....*....|....*....|....*.
gi 446124217 157 VLVTWASWHWIFLINIPIGVAGILYA 182
Cdd:cd17325 346 FLYDAFGFATPFLAAAALLLLAAVLF 371
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
8-417 |
1.81e-08 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 56.60 E-value: 1.81e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 8 SMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQsaiisYTLTVAMLIPVSGWLADRFGtRRVFMVAVSLFT 87
Cdd:pfam06609 45 SFAAFSLNVCATYFVLQASASALPNILQDIGQSENQGLFSTL-----WTMGQAVSILMMGRLTDRFG-RRPFVIATHIIG 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 88 L-----GSLACALSSSLSELVIFRVVQGVGGAMMMPVARLAllraYPRSELLPVLnFVTMPGLVGPILGPVLGGVLVTWA 162
Cdd:pfam06609 119 LvgaivGCTANKFNTLLAAMTLLGVAAGPAGASPLFIGELM----SNKTKFLGLL-IVSAPTIAMNGAGPYFGQRLAIQG 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 163 SWHWIFLINIPIGVAGILY--ARKYMPNFT------TPRR----KFDMTGFFLFGLSLVLFSSGMElFGEKIVATWIASA 230
Cdd:pfam06609 194 NWRWIFYIYIIMSAIAVLLiiIWYHPPSFAqlhgkkARKRdelaKLDWIGIFLVIAGTSLFLLGVS-WGGKPNNPWNSAK 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 231 II------FCSIVLLLAYIRHARRHpTPLISLSLFK-TRTFSVGIAgnLATRLGTG--CVPFLMPLMLQVGFGYPAL--- 298
Cdd:pfam06609 273 IIglissgAGSLVIFALYEVFGKPE-QPIIPPALFKdTRGFVCILI--ISSIMGAMhlCLTIIYPQQVINIFGSSLKnwe 349
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 299 IAGCMMAPTALGS---IIAKSTVTQVLRRLGYrKTLVG---ITVFIGLMiAQFSFQSPAMPIWMLVLPLFILGMAMSTQF 372
Cdd:pfam06609 350 ETAWMSATASFGTgagVMILGNLFHLIRHIRW-QILVGalwLTAFLGAM-SSINRDNKNAAIALSFFSGFVVAWAQDITM 427
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 446124217 373 TAMNTITladlTDDNASSGNSVLAVTQQLSislGVAISAAVLRIY 417
Cdd:pfam06609 428 LLVQFIT----TDEDLGVAFAVVAAARPFA---GSIFTAAFISLY 465
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
16-180 |
3.19e-08 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 55.60 E-value: 3.19e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 16 AAMAFFMQALD----ATILNTAL--PAIAHSLN--RSPLAMQSAIISYTLTVAMLIP-VSGWLADRFGTRRVFMVAVSLF 86
Cdd:PRK15403 12 AATLFFPMALIlydfAAYLTTDLiqPGIINVVRdfNADVSLAPASVSLYLAGGMALQwLLGPLSDRIGRRPVLITGALIF 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 87 TLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHW 166
Cdd:PRK15403 92 TLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLSGAALMHFVHWKV 171
|
170
....*....|....
gi 446124217 167 IFLInipIGVAGIL 180
Cdd:PRK15403 172 LFAI---IAVMGLI 182
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
22-120 |
9.57e-08 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 54.20 E-value: 9.57e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 22 MQALDATILNTALPAIAHSLNRSPLAMQ---SAIISYTLTVAMLipvSGWLADRFGTRRVFMVAVSLFTLGSLACALSSS 98
Cdd:PRK11551 26 LEGLDLQSAGVAAPRMAQEFGLDVAQMGwafSAGILGLLPGALL---GGRLADRIGRKRILIVSVALFGLFSLATAQAWD 102
|
90 100
....*....|....*....|....
gi 446124217 99 LSELVIFRVVQGV--GGAMMMPVA 120
Cdd:PRK11551 103 FPSLLVARLLTGVglGGALPNLIA 126
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
17-182 |
1.21e-07 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 53.71 E-value: 1.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 17 AMAFFMQALDATILNTALPAIAHSLNRSpLAMQSAIIS-----YTLTVAmlipVSGWLADRFGTRRVFMVAVSLFtlgSL 91
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWS-KTDQGLVLSsffwgYALTQV----LGGYLADRFGGKKVLLLAVALW---SL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 92 ACAL-----SSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHW 166
Cdd:cd17380 77 ATLLtpllaYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPS 156
|
170
....*....|....*.
gi 446124217 167 IFLInipIGVAGILYA 182
Cdd:cd17380 157 VFYF---FGLLGLLWA 169
|
|
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
18-182 |
1.31e-07 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 53.49 E-value: 1.31e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 18 MAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSS 97
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 98 SLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSE-LLPVLNFVTMPGLVGPILGPVLGGVLVTWaSWHWIFLInipIGV 176
Cdd:TIGR00893 81 AYVSLYILRVLLGAAEAPFFPGIILIVASWFPASErATAVSIFNSAQGLGGIIGGPLVGWILIHF-SWQWAFII---EGV 156
|
....*.
gi 446124217 177 AGILYA 182
Cdd:TIGR00893 157 LGIIWG 162
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
14-368 |
1.68e-07 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 53.55 E-value: 1.68e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQS----AIISYTLTVAMLipvsGWLADRFGTRRVFMVAVSLFTLG 89
Cdd:PRK03893 23 SAAWLGYLLDGFDFVLITLVLTEVQGEFGLTTVQAASlisaAFISRWFGGLLL----GAMGDRYGRRLAMVISIVLFSVG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 90 SLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFL 169
Cdd:PRK03893 99 TLACGFAPGYWTLFIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFF 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 170 INI-PIGVAgiLYARKYMPN---------------------FTTPRRKFDMTGFFLFGLSLVLFSSGMELFGEKIVATWI 227
Cdd:PRK03893 179 IGIlPIIFA--LWLRKNLPEaedwkekhagkapvrtmvdilYRGEHRIINILLTLAAAAALWFCFAGNLQNAAIVAVLGL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 228 ASAIIFCSIVLLLAyirhARRHPTPL-ISLSLFKTRTFSVGIAGnlatrlgtgcvpfLMPLMLQVGFGYPALIAGCMMAP 306
Cdd:PRK03893 257 LCAAIFISFMVQSS----GKRWPTGVmLMVVVLFAFLYSWPIQA-------------LLPTYLKTDLGYDPHTVANVLFF 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446124217 307 TALGSIIAKSTVTQVLRRLGYRKTLVgitvfIGLMIAQFsfqspampiwmLVLPLFILGMAM 368
Cdd:PRK03893 320 SGFGAAVGCCVGGFLGDWLGTRKAYV-----CSLLISQL-----------LIIPVFAIGGAN 365
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
14-187 |
3.08e-07 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 52.30 E-value: 3.08e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPlAMQSAIISYTLTV-AMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLA 92
Cdd:cd17371 2 WAAFLGWALDGFDLLLLGLVLPALIAEFGLDE-AEAGLLGTVTLAGgAIGGILGGILADRFGRVRVLVITILLFAVFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 93 CALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWAS----WHWIF 168
Cdd:cd17371 81 CGFAQNYWQLLILRALAGLGFGGEWAAGAALMAEYVPARHRGKALGYVQSGWAVGWLLATLLAALLFPLLPpeiaWRVLF 160
|
170
....*....|....*....
gi 446124217 169 LINIpIGVAGILYARKYMP 187
Cdd:cd17371 161 LLGA-LPALLVLFIRRFVK 178
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
14-171 |
3.95e-07 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 52.44 E-value: 3.95e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMA----FFMQALDATILNTALPAiahslnrSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLG 89
Cdd:pfam05977 16 WIASLAsnlgTLMQDVAASWLMTSLSA-------SPLMVALVQAAATLPIFLLSIPAGALADNFDRRKIMLAGQLLLALV 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 90 SLACALSS-----SLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASW 164
Cdd:pfam05977 89 STLLTLLAglgllSPWLLLGLTFLGGIGTALMDPAWQASVPELVPRRDLPAAVALNSVGYNIARSVGPALGGVLLAAFGP 168
|
....*..
gi 446124217 165 HWIFLIN 171
Cdd:pfam05977 169 AFTFALN 175
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
33-180 |
8.09e-07 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 51.05 E-value: 8.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 33 ALPAIAHSLNRSPlamqsAIISYTLTV-----AMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRV 107
Cdd:PRK11043 28 AFKAIQADLQTSA-----SAVSASLSLflagfALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLWVESAAQLLVLRF 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446124217 108 VQGVGgAMMMPVARLAL-LRAYPRSELLPVlnFVT-MPgLVG--PILGPVLGGVLVTWASWHWIFLINIPIGVAGIL 180
Cdd:PRK11043 103 VQAVG-VCSAAVIWQALvIDRYPAQKANRV--FATiMP-LVAlsPALAPLLGAWLLNHFGWQAIFATLFAITLLLIL 175
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
201-450 |
1.06e-06 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 51.06 E-value: 1.06e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 201 FFLFGLSLVLFSSGMELFGEKIVAtWIASAIIFCSIVLLLAYIRHARRHPTPLISL-----SLFKTRTFSVGIAGNLATR 275
Cdd:COG2211 163 ASVLPPPLVAAFGGDAALGYRLTA-LIFAVLGLLAFLLTFFGTKERPVPEEEKVSLkeslkALLKNRPFLLLLLAYLLFF 241
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 276 LGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFqSPAMPIW 355
Cdd:COG2211 242 LALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFF-LGPGNLW 320
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 356 MLVLPLFILGMAMSTQFTAMNTItLADLTD--------DNASSGNSVLAVTQQLSISLGVAISAAVLRIYEGFAGT---- 423
Cdd:COG2211 321 LLLVLAALAGIGLGAILVLPWAM-LADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVAGAaqsp 399
|
250 260
....*....|....*....|....*..
gi 446124217 424 STVEQFHYTFITMGAITIVSALMFMLL 450
Cdd:COG2211 400 SALTGIRLLFFLLPAVLLLLAALLLLF 426
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
15-257 |
1.42e-06 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 50.27 E-value: 1.42e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLA-MQSAIISYTLTVAMLIPV-SGWLADRFGTRRVFMVAVSLFTLGSLA 92
Cdd:cd17315 1 VAALGGLLFGYDLGVINGALLYIAKDLGFGLSTsLQGLVVSSLLLGAAIGSLfGGPLADRFGRRKSLLIAAVLYVIGALL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 93 CALSSSLSELVIFRVVQGVGGAMMMPVARLALlrayprSELLPVL---NFVTMPGL---VGPILGPVLGGVLVTWAS--W 164
Cdd:cd17315 81 SALAPNVWVLIVGRFLLGLGVGLASVLVPLYI------SEIAPAKirgALGTLNQLmitFGILLAYLLGLALSLSPPgwW 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 165 HWIFLINIPIGVAGILYArkympnFTTPRRKFDMTGFFLFGL-------------SLVLFSSGMELfgEKIVATWIASAI 231
Cdd:cd17315 155 RLMFALAAVPALLQLLLM------FFLPESRALLVGVGLQLLqqltginavmyyaPTIFKSAGGGT--ASILASIIVGVV 226
|
250 260
....*....|....*....|....*.
gi 446124217 232 IFCSIVLLLAYIRHARRHPTPLISLS 257
Cdd:cd17315 227 NLLATLVAIRLVDKVGRRPLLLIGFA 252
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
15-119 |
1.61e-06 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 49.96 E-value: 1.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLA--MQSAIISYTLTVAMLIP-VSGWLADRFGTRRVFMVAVSLFTLGSL 91
Cdd:cd17360 1 FAGIGGFLFGYDTGVISGALLYIKDDLGEVVLStgWQELIVSSTVAGAAVGAaIGGWLNDRFGRRPCILLADALFTIGAI 80
|
90 100 110
....*....|....*....|....*....|.
gi 446124217 92 ACALSSSLSELVIFRVVQGVG---GAMMMPV 119
Cdd:cd17360 81 VMAAAPNKEVLIVGRVLVGLGvgiASMTVPL 111
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
13-170 |
1.66e-06 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 49.96 E-value: 1.66e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 13 PWIAAMAFFMQALDATILNTA---LPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLG 89
Cdd:cd17355 2 WVVLAVTFLILILSWGIRYYFgvfIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 90 SLACALSSSLSELVI-FRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIF 168
Cdd:cd17355 82 LVLLALATSLWQLYLlWGLLGGGGAGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTAL 161
|
..
gi 446124217 169 LI 170
Cdd:cd17355 162 LV 163
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
64-195 |
2.01e-06 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 49.92 E-value: 2.01e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 64 PVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMP 143
Cdd:cd17329 53 LIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWA 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 446124217 144 GLVGPILGPVLGGVLVTwASWHWIFLINIPI-GVAGILYARKYMPNFTTPRRK 195
Cdd:cd17329 133 INLGVAIGPLLGGLLLL-YSFRLLFLAAAVLfLLAALVLLFLLPETRPKRRAA 184
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
52-363 |
4.82e-06 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 48.34 E-value: 4.82e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 52 IISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAmMMPVARLALLRAYPRS 131
Cdd:cd17330 40 QSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGG-NVSVAQAYIADITDEE 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 132 ELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGILYARKYMPNFTTPrrkfdMTGFFLFGLSLVLF 211
Cdd:cd17330 119 ERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNLVLVLFFLPPLRRL-----LLVYFLIALAFAGL 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 212 SSGMELFG--------EKIVATWIASAIIFCSIVLLLAYIRHARRHPTPLISLSLFktrtfsVGIAGNLATRLGTGcVPF 283
Cdd:cd17330 194 ESVFSLFLkdrfgfspSQIGLLLALVGIAGILAQLLLIPRLAKRLGERKLLRLGLL------LAIIGLLLLPFASS-VPL 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 284 LMPLMLQVGFGYPaliagcmMAPTALGSIIAKST-VTQVLRRLGYRKTLVGITVFIGLMIAQ--FSFQSPAMPIWMLVLP 360
Cdd:cd17330 267 LVLAAAILAFGTG-------IVFPALSALLSKSVpSKEQGKAQGIIQSLQSLARIIGPLLAGplYSFLGPGVPFLLAAGL 339
|
...
gi 446124217 361 LFI 363
Cdd:cd17330 340 LLI 342
|
|
| MFS_MosC_like |
cd17393 |
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of ... |
14-187 |
5.33e-06 |
|
Membrane protein MosC and similar proteins of the Major Facilitator Superfamily of transporters; The gene encoding Sinorhizobium meliloti membrane protein MosC is part of the mos locus, which encodes the biosynthesis of the rhizopine 3-O-methyl-scyllo-inosamine. MosC belongs to the bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4 (FucP/MFSD4) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340951 [Multi-domain] Cd Length: 373 Bit Score: 48.41 E-value: 5.33e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:cd17393 2 LAVAAFFFINGILMASWATRIPAIKDRLGLSDAALGLLLLALGVGALVAMPLAGRLVARFGSRRVTRLGALLLLLALLLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 94 ALSSSLSELVIFRVVQGVGGAMM---MPVARLALLRAYPRsellPVLNFVTMPGLVGPILGPVLGGVLVTW-ASWHWIFL 169
Cdd:cd17393 82 GLAPSVPALALALFLFGAANGALdvaMNAQGVAVERAYGR----PIMSSLHAMWSLGGLAGALLGAAAIGAgVSPGVHLL 157
|
170
....*....|....*...
gi 446124217 170 INIPIGVAGILYARKYMP 187
Cdd:cd17393 158 AAAVLLLLAALVAIRALL 175
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
3-170 |
6.51e-06 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 48.33 E-value: 6.51e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 3 SKKARSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLnRSPLAMQSAIISYTLTVAMLI-----PVSGWLADRFGTRR 77
Cdd:COG2807 6 SSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEI-RADLGLSATQAGLLTTLPLLAfglfaPLAPRLARRFGLER 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 78 VFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSeLLPVLNFVTMPGLVGPILGPVLGGV 157
Cdd:COG2807 85 TLLLALLLLAAGLLLRSLAPSVALLLAGTALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVP 163
|
170
....*....|...
gi 446124217 158 LVTWASWHWIFLI 170
Cdd:COG2807 164 LAAALGWRGALAV 176
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
64-170 |
1.04e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 47.64 E-value: 1.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 64 PVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPvARLALLRAY-PRSELLPVLNFVTM 142
Cdd:cd17391 258 PRLGKLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGLLP-AINSLLAKItPKEVAGRIFGYNQS 336
|
90 100
....*....|....*....|....*...
gi 446124217 143 PGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:cd17391 337 FQYLGNVAGPLLGSAIAAHFGYRAVFVV 364
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-178 |
1.30e-05 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 47.27 E-value: 1.30e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 30 LNTALPAIAHS--LNRSPLAMQSAIISYTLTVAMLIpvSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRV 107
Cdd:cd17312 22 FSVAKPPIVEEigLSKDDLGIIGSAFLIAYAVGKFI--SGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWG 99
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446124217 108 VQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAG 178
Cdd:cd17312 100 LNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVV 170
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
59-170 |
2.18e-05 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 46.46 E-value: 2.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 59 VAMLIPvSGWLADRFGTRRVFMVAV---SLFTLGSLACAlSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLP 135
Cdd:cd17318 70 ILTQIP-GGYLAEKYGAKRVLGYSIlitALLTLLTPLAA-RGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSR 147
|
90 100 110
....*....|....*....|....*....|....*
gi 446124217 136 VLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:cd17318 148 LTSIAYSGSQFGTVIAMPLSGFLCESLGWPSIFYI 182
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
15-112 |
2.54e-05 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 46.50 E-value: 2.54e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVS-----GWLADRFGTRRVFMVAVSLFTLG 89
Cdd:cd17364 3 IAGMGFFTDAYDLFSISLVTKILGRLYYGGKGSLPSGVSGLVNAAALVGTIIgqlffGFLGDRFGRKRVYGVELIIMIIG 82
|
90 100
....*....|....*....|....*....
gi 446124217 90 SLACALSSS------LSELVIFRVVQGVG 112
Cdd:cd17364 83 TILSALSPGstplgvMGWLIFFRFLLGIG 111
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
65-180 |
2.67e-05 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 46.41 E-value: 2.67e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 65 VSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYP---RSELLPVLNFVt 141
Cdd:cd17474 254 VGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPeeeRGTASSLYNFV- 332
|
90 100 110
....*....|....*....|....*....|....*....
gi 446124217 142 mpGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGIL 180
Cdd:cd17474 333 --RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
14-120 |
7.80e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 7.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLAC 93
Cdd:COG2211 232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLL 311
|
90 100
....*....|....*....|....*....
gi 446124217 94 ALS--SSLSELVIFRVVQGVGGAMMMPVA 120
Cdd:COG2211 312 FFLgpGNLWLLLVLAALAGIGLGAILVLP 340
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
12-181 |
1.26e-04 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 44.16 E-value: 1.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 12 LPWIAaMAFFMQALD-ATILNTALPAIAHSLNrsplaMQSAIISYTLTVAMLI-----PVSGWLADRFGTRRVFMVAVSL 85
Cdd:cd17327 7 LPLLC-ILYFLQYLDkSNISNAAVMGMKEDLK-----LVGNQYNWGNTVFYVGyiifeLPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 86 FTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLG-GVLV----- 159
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAyGVFKilgvg 160
|
170 180
....*....|....*....|....*.
gi 446124217 160 TWASWHWIFLI----NIPIGVAGILY 181
Cdd:cd17327 161 GLAGWRWLFIIegliTIIIGLVIFFW 186
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
30-176 |
1.54e-04 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 43.90 E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 30 LNTALPAIAHS--LNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRV 107
Cdd:TIGR00881 14 FALAMPYLVEEigLSKTDLGLLLSSFSIAYGISKF--VMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWA 91
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 108 VQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWA-SWHWIFLINIPIGV 176
Cdd:TIGR00881 92 LNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAI 161
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
49-170 |
1.57e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 43.70 E-value: 1.57e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 49 QSAIISYTLTVAMLI--PVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVI-FRVVQGVGGAMMMPVARLALL 125
Cdd:cd17352 39 DIAWIGSLLLGVSLFsgPLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLYLtYGVLGGLGLGLIYSPAIVIVG 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 446124217 126 RaYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLI 170
Cdd:cd17352 119 Q-YFEKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLI 162
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
15-367 |
1.91e-04 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 43.77 E-value: 1.91e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 15 IAAMAFFMQAldatilntalpaiAHSLNRSPLAMQSAIISYTLTVAMLipVSGWLADRFGTRRVFMVAVSLFTLGSLACA 94
Cdd:cd17475 15 IPALAPFLQE-------------DLHLSLAQVGLLLSALNLGVAVSML--PAGWLLDRFGERRVLAVGLLLMGAAALLMA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 95 LSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPI 174
Cdd:cd17475 80 LVGSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 175 GVAGILYARKYMPNFTTPRRKFDMTGFFLFGLSLVLFSSGMELFGekivatwIASAIIFCSIVLLLAYirharrhptpli 254
Cdd:cd17475 160 SILAAVLFWLFYREPPAASAATESASTLLRSLKEVLRNRDVWLIA-------IAGALLVAPQFALLTF------------ 220
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 255 slslfktrtfsvgiagnlatrlgtgcvpflMPLMLQVGFGYPALIAGCMMAPTALGSIIAK---STVTQVLRRLGYRKTL 331
Cdd:cd17475 221 ------------------------------LLLFLHDHLGLSVVAAGALLAVAQLGGALGRiglGRVSDRVFGGRRRPVL 270
|
330 340 350
....*....|....*....|....*....|....*.
gi 446124217 332 VGITVFIGLMIAQFSFQSPAMPIWMLVLPLFILGMA 367
Cdd:cd17475 271 VITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLF 306
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
51-188 |
2.11e-04 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 43.36 E-value: 2.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 51 AIISYTLTVAML-IPVsGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGvGGAMMMPVarLALLRAYP 129
Cdd:cd17472 37 ALGIYGLTQAIFqIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVV--MALLADLT 112
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446124217 130 RSE-------LLPVLNFVTMpgLVGPILGPVLGGVLvtwaSWHWIFLINIPIGVAGILYARKYMPN 188
Cdd:cd17472 113 REEnrtkamaLIGASIGIAF--AISMVLGPLLAAHL----GVSGLFLITAILSLVSLLILLFFVPD 172
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
55-120 |
2.20e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 43.34 E-value: 2.20e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446124217 55 YTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVA 120
Cdd:cd17317 34 FFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVG 99
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
34-161 |
3.45e-04 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 42.60 E-value: 3.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 34 LPAIAHSLNRSPlaMQSAIISYTLTVAMLI--PVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGV 111
Cdd:cd17390 19 LSTHIRSLGASP--TVIGLIGSVYGALQLFssPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGI 96
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446124217 112 GGAMMMpVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTW 161
Cdd:cd17390 97 FKHTQS-LCKAYLSDLVSEQERSRVLGRFNAASSLGFILGPVVGGHLAET 145
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
21-417 |
7.66e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.78 E-value: 7.66e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 21 FMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLS 100
Cdd:cd17477 6 ALLGLGSGLLLPLLSLRLEREGVSTALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 101 ELVIFRVVQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVlvtwaswhwiflinipigvagil 180
Cdd:cd17477 86 VWFLLRFVMGIGLAGLFVVSESWLNALATNENRGRVLGLYSTVLGLGFALGPLLLAL----------------------- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 181 yarkympnfttprrkFDMTGFFLFglslvlfssgmelfgekivatWIASAIIFCSIVLLLAYIRHARRHPTPLISLSLFK 260
Cdd:cd17477 143 ---------------VGTAGALPF---------------------LIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRL 186
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 261 TRTFSVGIAGNLATRLGTGCVPFLMPLMLqVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGL 340
Cdd:cd17477 187 LRIAPLALLGAFVAGFLEGAFYSLLPLYG-LRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGAL 265
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446124217 341 MIAQFSFQSPAMpiWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIY 417
Cdd:cd17477 266 AALLLPLVPGLP--LALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAF 340
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
270-466 |
1.02e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 41.25 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 270 GNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSFQS 349
Cdd:pfam07690 4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFAS 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 350 PampIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIYEgfagtstveqF 429
Cdd:pfam07690 84 S---LWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFG----------W 150
|
170 180 190
....*....|....*....|....*....|....*..
gi 446124217 430 HYTFITMGAITIVSALMFMLLRVKDGNNLIKERHKSK 466
Cdd:pfam07690 151 RAAFLILAILSLLAAVLLLLPRPPPESKRPKPAEEAR 187
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
65-211 |
1.59e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 40.80 E-value: 1.59e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 65 VSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQG--VGGAMMMPVARLALLRAYPRSELLPVLN--FV 140
Cdd:cd17362 58 VAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGvgIGLAMHAAPVYIAETSPSHIRGLLVSLKelFI 137
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446124217 141 TMPGLVGPILGPVLGGVLvtwASWHWIFLINIPIGVA-GILYARkyMPnfTTPRRKFDMTGFFLFGLSLVLF 211
Cdd:cd17362 138 VLGILLGYVSGYAFADVV---GGWRYMYGLAAPPALLlGIGMWF--LP--PSPRWQGNYRKPLIIGLGLVLF 202
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
29-195 |
2.22e-03 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 40.23 E-value: 2.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 29 ILNTALPAIAHSLNRSpLAMQSAIIS-YTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRV 107
Cdd:cd17478 14 FLPALLPLLIAKLGLS-YAQAGLLVSvFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 108 VQGVGGAMMMPVARLALLRAYPRSELLPVLNFVTMpGLVGPILGPVLGGVLVT-WASWHWIFLINIPIGVAGILYARKYM 186
Cdd:cd17478 93 LAGIGSAAFHPEGARLASQAAGGRRGLAMSIFSVG-GNLGFALGPLIAAALVAlFGGLGLLILLIIPGLAVALLLLRLRP 171
|
....*....
gi 446124217 187 PNFTTPRRK 195
Cdd:cd17478 172 LKKPEAKKA 180
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
297-454 |
2.70e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 39.84 E-value: 2.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 297 ALIAGCMMAPTALGSIIAkstvTQVLRRLGYRKTLVGITVFIGLMIAQFSFqspAMPIWMLVLPLFILGMAMSTQFTAMN 376
Cdd:COG0738 46 GLLLFAFFLGYLLASLPA----GRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGLGLLDVAAN 118
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446124217 377 TItLADLTDDNASSGNSVLavtqQLSISLGVAISAAVLRIyegFAGTSTVEQFHYTFITMGAITIVSALMFMLLRVKD 454
Cdd:COG0738 119 PY-VAALGPETAASRLNLL----HAFFSLGALLGPLLGGL---LILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPE 188
|
|
| PRK10091 |
PRK10091 |
MFS transport protein AraJ; Provisional |
34-188 |
2.74e-03 |
|
MFS transport protein AraJ; Provisional
Pssm-ID: 182234 [Multi-domain] Cd Length: 382 Bit Score: 40.08 E-value: 2.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 34 LPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIFRVVQGVGG 113
Cdd:PRK10091 26 LTELAHDVGISIPAAGHMISYYALGVVVGAPIIALFSSRYSLKHILLFLVALCVIGNAMFTLSSSYLMLAIGRLVSGFPH 105
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446124217 114 AMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGILYARKYMPN 188
Cdd:PRK10091 106 GAFFGVGAIVLSKIIKPGKVTAAVAGMVSGMTVANLLGIPLGTYLSQEFSWRYTFLLIAVFNIAVLASIYFWVPD 180
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
51-368 |
4.86e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 39.17 E-value: 4.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 51 AIISYTLTVAMLIPVSGWLADRFGtRRVFMVAVSL-FTLGSLACALSSSLSELVIFRVVQGV-----GGAMMMpVARLAl 124
Cdd:cd17391 41 AFSSTFLVSAIFSPIWGRLADRYG-RKPMLLRASLgMAIVIGLMAFVTNVWQLLILRLLQGVfsgyvPNATAL-IASQT- 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 125 lrayPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWaswhwiflinipIGVagilyarkympnfttpRRKFDMTGFFLF 204
Cdd:cd17391 118 ----PKEKSGWALGTLSTGVVAGTLIGPLLGGFLADL------------FGI----------------RNVFFITGGLLF 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 205 GLSLVLFSSGMELFGEKIVATWIASAIIFCSIvlllayirharrhPTPLISLSLFKTRtfsvgiagnLATRLGTGCVPFL 284
Cdd:cd17391 166 LAFLLTLFFVKEDFKPVEKKKMVSTKEVWNSV-------------PNPSLLISLFVTT---------FIIQLANQSIEPI 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 285 MPL---MLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLM-IAQFSFQSPampiWMLVLP 360
Cdd:cd17391 224 LTLyirQLMGDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLASALLyIPQAFVQTP----WQLGIL 299
|
....*...
gi 446124217 361 LFILGMAM 368
Cdd:cd17391 300 RFLLGLAT 307
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
67-182 |
5.14e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 39.08 E-value: 5.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 67 GWLADRFGTRRVFMVAVSLFTLGSLACALSSSLSELVIfrVVQGVGGAMMMPVARLALLRA---YPRSELLPVLNFVTMP 143
Cdd:cd17477 244 GWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALL--VLLFLWGGAAGPLYTLALALAgdrLPGDELVAANAALLLL 321
|
90 100 110
....*....|....*....|....*....|....*....
gi 446124217 144 GLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGILYA 182
Cdd:cd17477 322 YGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK03699 |
PRK03699 |
putative transporter; Provisional |
7-170 |
5.77e-03 |
|
putative transporter; Provisional
Pssm-ID: 235151 [Multi-domain] Cd Length: 394 Bit Score: 38.75 E-value: 5.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 7 RSMAGLPWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMqSAIISYtLTVAMLIPV--SGWLADRFGTRRVFMVAVS 84
Cdd:PRK03699 3 SNRIKLTWISFLSYALTGALVIVTGMVMGPIAEYFNLPVSSM-SNTFTF-LNAGILISIflNAWLMEIIPLKRQLIFGFA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 85 LFTLGSLACALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYP---RSELLPVLN-FVTMPGLVGPILGPVLggvLVT 160
Cdd:PRK03699 81 LMILAVAGLMFSHSLALFSIAMFVLGVVSGITMSIGTFLITHVYEgkqRGSRLLFTDsFFSMAGMIFPIIAAYL---LAR 157
|
170
....*....|
gi 446124217 161 WASWHWIFLI 170
Cdd:PRK03699 158 SIEWYWVYAC 167
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
34-180 |
7.13e-03 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 38.74 E-value: 7.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 34 LPAIAHSLNRSPLAMQSAIISYTLTVAML-IPVsGWLADRFGTRRVFMVAVSLFT-LGSLACALSSSLSELVIFRVVQGV 111
Cdd:cd17490 19 LSPYAESLGASLSMIGIILGAYGISQMLLrIPL-GILSDRIGKRKLFIIIGLLFTvLASLIMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446124217 112 GGAMMMpVARLALLRAYPRSELLPVLNFVTMPGLVGPILGPVLGGVLVTWASWHWIFLINIPIGVAGIL 180
Cdd:cd17490 98 AAATWV-SFTVLYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFI 165
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
14-398 |
7.40e-03 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 38.46 E-value: 7.40e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 14 WIAAMAFFMQALDATILNTALPAIAHSlnrsPLAMQSAIISYTLTVAMLIPV-SGWLADRFGTRRVFMVAVSLFTLGSLA 92
Cdd:cd17333 2 YISFFSNGLTDALLGILGPSLEEAFNL----NVADVSVIFSSQNAGYLIGSLlAGFLMKRLGRRRTLILGLLLISLALAL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 93 CALSSSLSELVIFRVVQGVGGAMMMPVARLALLRAYPRS--ELLPVLNFVTMpglVGPILGPVLGGVLVTW-ASWHWIFL 169
Cdd:cd17333 78 IFATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEESsaTRLNVLHGFFG---LGALIGPLIATSLLTSeLSWSWAYL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 170 INIPIGVAGILyarkympnfttprrkfdmtgFFLFGLSLVLFSSGMELFGEKIVATWIASAIIFCSIVLLLAYIrharrh 249
Cdd:cd17333 155 IIGLIYLLLAI--------------------LILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALAL------ 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 250 ptplislslfktrTFSVGIAGNLATrlgtgcvpfLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRK 329
Cdd:cd17333 209 -------------FLYVGAETAFSS---------WVPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHT 266
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446124217 330 TLVGITVfiGLMIAQFSFQSPAMPIWMLVLpLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVT 398
Cdd:cd17333 267 LLVLSGS--GALLGLLILLLAPTLVVGLVA-TALLGLFMAALFPTILSLGISNLPYAKGKGTSVLLAAG 332
|
|
| MFS_GLUT_Class1_2_like |
cd17357 |
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ... |
64-180 |
7.68e-03 |
|
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340915 [Multi-domain] Cd Length: 447 Bit Score: 38.78 E-value: 7.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 64 PVSGWLADRFGTRRVFMVAVSLFTLGSL--ACALSSSLSELVIF-RVVQGVGGAMMMPVARLALLRAYPrSELLPVLNFV 140
Cdd:cd17357 67 FISAFLANRFGRKNGLLISNALLVVSSLlmFLSKSAKSPELLIFgRFLVGIACGLSTGFVPMYLQEISP-SELRGALGSL 145
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90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446124217 141 TMPGLVGPIL-GPVLG--GVLVTWASWHWIFLINIPIGVAGIL 180
Cdd:cd17357 146 TQIGVTLGILlGQVFGlpSVLGTETLWPYLLFFPGIPALLQLA 188
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| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
268-417 |
8.30e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.36 E-value: 8.30e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 268 IAGNLATRLGTGCVPFLMPLMLQVGFGYPALIAGCMMAPTALGSIIAKSTVTQVLRRLGYRKTLVGITVFIGLMIAQFSF 347
Cdd:cd17329 5 LIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF 84
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 348 qspAMPIWMLVLPLFILGMAMSTQFTAMNTITLADLTDDNASSGNSVLAVTQQLSISLGVAISAAVLRIY 417
Cdd:cd17329 85 ---AHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYS 151
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| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
13-152 |
9.62e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 38.17 E-value: 9.62e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446124217 13 PWIAAMAFFMQALDATILNTALPAIAHSLNRSPLAMQSAIISYTLTVAMLIPVSGWLADRFGTRRVFMVAVSLFTLGSLA 92
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALG 281
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446124217 93 CALSSSLSELVIFRVVQ---GVGGAMMMPVARLALLRAYPRSELLPVLNFVTMPGLVGPILGP 152
Cdd:pfam07690 282 LLLLSLTLSSLWLLLALlllGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
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