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Conserved domains on  [gi|446120359|ref|WP_000198214|]
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MULTISPECIES: aromatic amino acid efflux DMT transporter YddG [Enterobacteriaceae]

Protein Classification

drug/metabolite transporter permease( domain architecture ID 11485459)

drug/metabolite transporter (DMT) permease is an inner membrane protein involved in the transport of one or more of a variety of substrates such as amino acids, drugs, metabolites, and sugar phosphates, among others; similar to Escherichia coli methyl viologen resistance protein YddG

PubMed:  17784858|27281193

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
PRK11689 PRK11689
aromatic amino acid efflux DMT transporter YddG;
2-292 3.55e-171

aromatic amino acid efflux DMT transporter YddG;


:

Pssm-ID: 183277 [Multi-domain]  Cd Length: 295  Bit Score: 475.13  E-value: 3.55e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359   2 TRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQIPKGYLLAGSLLFVSYEICLAL 81
Cdd:PRK11689   1 TSQKATLIGLIAILLWSTMVGLIRGVSESLGPVGGAAMIYSVSGLLLLLTVGFPRLRQFPKRYLLAGGLLFVSYEICLAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  82 SLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFL 161
Cdd:PRK11689  81 SLGYANTRRQAIEVGMVNYLWPSLTILFAVLFNGQKANWLLIPGLLLALAGVAWVLGGDNGLSLAELINNIASNPLSYGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359 162 AFIGAFIWAAYCTVTNKYARGFNGITVFVLLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAWNVGILHGN 241
Cdd:PRK11689 161 AFIGAFIWAAYCNVTRKYARGKNGITLFFILTALALWIKYFLSPQPAMVFSLPAIIKLLLAAAAMGFGYAAWNVGILHGN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446120359 242 VTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLLCWLATRR 292
Cdd:PRK11689 241 MTLLATASYFTPVLSAALAALLLSTPLSFSFWQGVAMVTAGSLLCWLATRR 291
 
Name Accession Description Interval E-value
PRK11689 PRK11689
aromatic amino acid efflux DMT transporter YddG;
2-292 3.55e-171

aromatic amino acid efflux DMT transporter YddG;


Pssm-ID: 183277 [Multi-domain]  Cd Length: 295  Bit Score: 475.13  E-value: 3.55e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359   2 TRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQIPKGYLLAGSLLFVSYEICLAL 81
Cdd:PRK11689   1 TSQKATLIGLIAILLWSTMVGLIRGVSESLGPVGGAAMIYSVSGLLLLLTVGFPRLRQFPKRYLLAGGLLFVSYEICLAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  82 SLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFL 161
Cdd:PRK11689  81 SLGYANTRRQAIEVGMVNYLWPSLTILFAVLFNGQKANWLLIPGLLLALAGVAWVLGGDNGLSLAELINNIASNPLSYGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359 162 AFIGAFIWAAYCTVTNKYARGFNGITVFVLLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAWNVGILHGN 241
Cdd:PRK11689 161 AFIGAFIWAAYCNVTRKYARGKNGITLFFILTALALWIKYFLSPQPAMVFSLPAIIKLLLAAAAMGFGYAAWNVGILHGN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446120359 242 VTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLLCWLATRR 292
Cdd:PRK11689 241 MTLLATASYFTPVLSAALAALLLSTPLSFSFWQGVAMVTAGSLLCWLATRR 291
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
3-292 1.99e-24

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 99.53  E-value: 1.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359   3 RQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGF------PRIRQIPKGYLLAGSLLFVSYE 76
Cdd:COG0697    1 RLRGILLLLLAALLWGSSFVAIKLALAGLPPLQLAFLRFLLAALLLLPLLLLrgrrlpPLSRRDWLLLLLRGLLGLALAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  77 ICLALSLGYAatrhQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHydeiinniTTSP 156
Cdd:COG0697   81 LLFFLALQYT----PAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGG--------GGSL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359 157 LSYFLAFIGAFIWAAYCTVTNKYARGFNGITV---FVLLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAW 233
Cdd:COG0697  149 LGDLLALLAALSWALYTVLTRRLSRRLDPLTLtfwQMLVGALLLLPLALLTGLPLPLSAAAWLALLYLGLFGTALAYLLW 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446120359 234 NVGILHGNVTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLLCWLATRR 292
Cdd:COG0697  229 FRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERR 287
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
159-285 4.94e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 39.49  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  159 YFLAFIGAFIWAAYCTVTNKYARGFNGITVFV---LLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAWNV 235
Cdd:pfam00892   4 ILLALLAALIWAIYFVFSKILLRRISPLTLTFwrfLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLLYFY 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 446120359  236 GILHGNVTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLL 285
Cdd:pfam00892  84 GLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133
 
Name Accession Description Interval E-value
PRK11689 PRK11689
aromatic amino acid efflux DMT transporter YddG;
2-292 3.55e-171

aromatic amino acid efflux DMT transporter YddG;


Pssm-ID: 183277 [Multi-domain]  Cd Length: 295  Bit Score: 475.13  E-value: 3.55e-171
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359   2 TRQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGFPRIRQIPKGYLLAGSLLFVSYEICLAL 81
Cdd:PRK11689   1 TSQKATLIGLIAILLWSTMVGLIRGVSESLGPVGGAAMIYSVSGLLLLLTVGFPRLRQFPKRYLLAGGLLFVSYEICLAL 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  82 SLGYAATRHQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHYDEIINNITTSPLSYFL 161
Cdd:PRK11689  81 SLGYANTRRQAIEVGMVNYLWPSLTILFAVLFNGQKANWLLIPGLLLALAGVAWVLGGDNGLSLAELINNIASNPLSYGL 160
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359 162 AFIGAFIWAAYCTVTNKYARGFNGITVFVLLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAWNVGILHGN 241
Cdd:PRK11689 161 AFIGAFIWAAYCNVTRKYARGKNGITLFFILTALALWIKYFLSPQPAMVFSLPAIIKLLLAAAAMGFGYAAWNVGILHGN 240
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446120359 242 VTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLLCWLATRR 292
Cdd:PRK11689 241 MTLLATASYFTPVLSAALAALLLSTPLSFSFWQGVAMVTAGSLLCWLATRR 291
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
3-292 1.99e-24

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 99.53  E-value: 1.99e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359   3 RQKATLIGLIAIVLWSTMVGLIRGVSEGLGPVGGAAAIYSLSGLLLIFTVGF------PRIRQIPKGYLLAGSLLFVSYE 76
Cdd:COG0697    1 RLRGILLLLLAALLWGSSFVAIKLALAGLPPLQLAFLRFLLAALLLLPLLLLrgrrlpPLSRRDWLLLLLRGLLGLALAF 80
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  77 ICLALSLGYAatrhQAIEVGMVNYLWPSLTILFAILFNGQKTNWLIVPGLLLALVGVCWVLGGDNGLHydeiinniTTSP 156
Cdd:COG0697   81 LLFFLALQYT----PAALAALLLALAPLFVALLAALLLGERLSRRRWLGLLLGFAGVLLIVGPGGGGG--------GGSL 148
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359 157 LSYFLAFIGAFIWAAYCTVTNKYARGFNGITV---FVLLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAW 233
Cdd:COG0697  149 LGDLLALLAALSWALYTVLTRRLSRRLDPLTLtfwQMLVGALLLLPLALLTGLPLPLSAAAWLALLYLGLFGTALAYLLW 228
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 446120359 234 NVGILHGNVTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLLCWLATRR 292
Cdd:COG0697  229 FRALRRLGASRAAPLTYLEPVFAVLLGWLLLGEPLTPLQLLGAALILAGVLLAALRERR 287
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
159-285 4.94e-04

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 39.49  E-value: 4.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446120359  159 YFLAFIGAFIWAAYCTVTNKYARGFNGITVFV---LLTGASLWVYYFLTPQPEMVFSTPVMIKLISAAFTLGFAYAAWNV 235
Cdd:pfam00892   4 ILLALLAALIWAIYFVFSKILLRRISPLTLTFwrfLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVLGTFLGFLLYFY 83
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 446120359  236 GILHGNVTIMAVGSYFTPVLSSALAAVLLSAPLSFSFWQGALMVCGGSLL 285
Cdd:pfam00892  84 GLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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