|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
9-382 |
3.10e-92 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 281.77 E-value: 3.10e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 9 ALILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSIL 88
Cdd:cd17320 1 LLLLALLVALGPLAIDMYLPALPAIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 89 CATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMA 168
Cdd:cd17320 81 CALASSIEQLLIARFLQGLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPALAPLLGGLLLLFFGWRAIFVFLA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 169 EISTVLLLGCLLFINETLPENKRG---SSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFS 245
Cdd:cd17320 161 LLGLLLLLLVLLFLPETLPEEKRKpllSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 246 LVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCA-WIQLPIPALVALFFTIAFCSGIGTVGGAEAM 324
Cdd:cd17320 241 LLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAAlLGGLSLWPLVAPLFLIFFGFGLIFPNATSLA 320
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 446057161 325 SAVGTQESGTASALMGMSMFVFGGIAAPLSG-IGGETLLKMSLAITVCYTLALLVALTR 382
Cdd:cd17320 321 LEPFPHVAGTASALLGFLQFLIGALAGALVGlLPNGTALPMGLLILVLGLLALLLLILL 379
|
|
| efflux_Bcr_CflA |
TIGR00710 |
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ... |
9-377 |
4.03e-63 |
|
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.
Pssm-ID: 273229 [Multi-domain] Cd Length: 385 Bit Score: 206.85 E-value: 4.03e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 9 ALILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSIL 88
Cdd:TIGR00710 7 ALLLGCLSILGPLGIDMYLPAFPEIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLG 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 89 CATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMA 168
Cdd:TIGR00710 87 LALSNNIETLLVLRFVQAFGASAGSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPLLGGYILVWLSWHAIFAFLS 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 169 EISTVLLLGCLLFINETLPENKRGSSLL--LTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSL 246
Cdd:TIGR00710 167 LAGILLSALIFFILPETLPYEARIQISTyfETFLLLLKSKMFWGYALIYGASFGGFFAFFSGAPFVYIDIMGVSPSVFGL 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 247 VFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCAWIQLPipaLVALFFTIAFCSGIG-----TVGGA 321
Cdd:TIGR00710 247 LFALNIIAMIFGGFLNGRFIKKWGAKSLLRMGLILFAVSAVLLEITAILGLG---SWAMIIGPMMFVGIGnsmisSIAMA 323
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 446057161 322 EAMSAVGTQeSGTASALMGMSMFVFGGIAAPL-SGIGGETLLKMSLAITVCYTLALL 377
Cdd:TIGR00710 324 YALEDFPHV-AGTASALFGTLRLVLGAIVGYLvSLIHGNTAWPMSLSCLVLAVVSVL 379
|
|
| PRK11102 |
PRK11102 |
Bcr/CflA family multidrug efflux MFS transporter; |
20-377 |
1.75e-50 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182964 [Multi-domain] Cd Length: 377 Bit Score: 173.56 E-value: 1.75e-50
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 20 PMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLV 99
Cdd:PRK11102 4 PLAIDMYLPALPVIAADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLI 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 100 VWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCL 179
Cdd:PRK11102 84 YMRFLHGLAAAAASVVINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGWLLVWFSWHAIFWVLALAAILAAALVF 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 180 LFINETLPENKRGS-SLLLTGR---SVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGL 255
Cdd:PRK11102 164 FFIPETLPKERRQPfHLRTTIRnfaSLFRHKRVLGYMLASGFSFAGMFSFLTAGPFVYIELNGVSPQNFGYYFALNIVFL 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 256 IIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCAWIQLPIPALValFFTIAFCSGIGTVgGAEAMSAVGT---QES 332
Cdd:PRK11102 244 FVMTIINSRFVRRVGALNMLRFGLWIQFIMGIWLVVSALLDLGFWALV--VGVAAFVGCVSMI-SSNAMAVILDefpHMA 320
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 446057161 333 GTASALMGMSMFVFGGIA-APLSGIGGETLLKMSLAITVCYTLALL 377
Cdd:PRK11102 321 GTASSLAGTLRFGIGAIVgALLSLAPFTSAWPMVWSMAFCSILSIL 366
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
10-350 |
3.30e-46 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 161.68 E-value: 3.30e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 10 LILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILC 89
Cdd:COG2814 13 LALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 90 ATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAE 169
Cdd:COG2814 93 ALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAV 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 170 ISTVLLLGCLLFINETLPENKRgsSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:COG2814 173 LALLALLLLLRLLPESRPAARA--RLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLA 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 250 LNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTvlcAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGT 329
Cdd:COG2814 251 LFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLL---ALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPP 327
|
330 340
....*....|....*....|.
gi 446057161 330 QESGTASALMGMSMFVFGGIA 350
Cdd:COG2814 328 EARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
11-383 |
3.51e-36 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 135.39 E-value: 3.51e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 11 ILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCA 90
Cdd:cd17474 3 AVFFATLLAVLGVSIVDPILPAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 91 TTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVsTFDWRTLFWVMAEI 170
Cdd:cd17474 83 LSDSFALLLAGRALQGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGGLLA-AISWRYPFFLLAAL 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 171 STVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFML-AGLFAYIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:cd17474 162 IPVAFLAILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYfFLYFAFLTYLPFLLELLYGISPIIIGLLFA 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 250 LNGIGLIIASWIFSR-LARRINAMTLLRGGLI--AAILCALLTVLCAWIQLPIPALVALFFTIAFcsgigTVGGAEAMSA 326
Cdd:cd17474 242 GWSVLLALGSLFVGRlLKKRFGARRILVIGLLlyALSLLLLGFVPSLALLLIAIVLFGLGLGLNL-----PLLTTLVTEL 316
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 327 VGTQESGTASALMGMSMFVFGGIAAPLSGIGGETL-LKMSLAITVCYTLALLVALTRI 383
Cdd:cd17474 317 APEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFgLSAPFLVGAAIALAAAVLLALL 374
|
|
| emrD |
PRK11652 |
multidrug transporter EmrD; |
10-310 |
3.42e-35 |
|
multidrug transporter EmrD;
Pssm-ID: 183259 [Multi-domain] Cd Length: 394 Bit Score: 133.11 E-value: 3.42e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 10 LILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILC 89
Cdd:PRK11652 11 FMLVLLVAVGQMAQTIYVPAIADMARDLNVREGAVQAVMAAYLLTYGLSQLFYGPLSDRVGRRPVILVGMSIFILGTLVA 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 90 ATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAE 169
Cdd:PRK11652 91 LFAHSLTVLIAASAIQGLGTGVGGVMARTLPRDLYEGTQLRHANSLLNMGILVSPLLAPLIGGLLTTLFGWRACYLFLLL 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 170 ISTVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:PRK11652 171 LGAGVTFSMARWMPETRPADARRTRVLASYRTLLSNRRFNCYLLMLIGTLAGIAVFEACSGVLMGAVLGLSSMTVSILFI 250
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446057161 250 LNGIGLIIASWIFSRLARRINamTLLRGGLIAAILCALLTVLCAWIQ------LPIPAlvALFFTIA 310
Cdd:PRK11652 251 LPIPAAFFGAWFAGRPNKRFS--TLMWQSVICCLLAGLLMWIPGWFGvmnvwtLLVPA--ALFFFGA 313
|
|
| PRK11043 |
PRK11043 |
Bcr/CflA family multidrug efflux MFS transporter; |
12-357 |
1.23e-33 |
|
Bcr/CflA family multidrug efflux MFS transporter;
Pssm-ID: 182924 [Multi-domain] Cd Length: 401 Bit Score: 129.24 E-value: 1.23e-33
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 12 LGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCAT 91
Cdd:PRK11043 11 LAGLSMLGFLATDMYLPAFKAIQADLQTSASAVSASLSLFLAGFALGQLLWGPLSDRYGRKPVLLAGLSLFALGSLGMLW 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 92 TNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEIS 171
Cdd:PRK11043 91 VESAAQLLVLRFVQAVGVCSAAVIWQALVIDRYPAQKANRVFATIMPLVALSPALAPLLGAWLLNHFGWQAIFATLFAIT 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 172 TVLLLGCLLFINEtlPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQkEFGFNPMQFSLVFGLN 251
Cdd:PRK11043 171 LLLILPTLRLKPS--KKARKQSQDALTFKQLLKSKTYLGNVLIFAACSAAFFAWLTGSPFILE-QMGYSPADIGLSYVPQ 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 252 GIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCAWIQLP-IPALVALFFTIAFCSG-IGTVGGAEAMSAVgT 329
Cdd:PRK11043 248 TIAFLVGGYGCRAALQKWGGEQLLPWLLVLFAVSVIAIWLASLLSHPsLVPLLIPFCVMAAANGaIYPIVVAQALRPF-P 326
|
330 340 350
....*....|....*....|....*....|....*..
gi 446057161 330 QESGTASAL---------MGMSMFVFGGIAAPLSGIG 357
Cdd:PRK11043 327 QATGKAAALqntlqlglcFLASLLVSALISTPLLTTG 363
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
23-356 |
1.46e-31 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 122.66 E-value: 1.46e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 23 TDLYLPA--LPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVV 100
Cdd:cd17324 13 TTEYVIQglLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 101 WRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLL 180
Cdd:cd17324 93 ARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWR 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 181 FINETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASW 260
Cdd:cd17324 173 LLPSLPPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSP 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 261 IFSRLARRINAMTLLRGGLIAAILCALLTVLCAWiqlpIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMG 340
Cdd:cd17324 253 LAGRLADRGGRRALLIALLLLAAALLLLTLLGPS----PLLLLVGLVLWGLGFFAAHSALQTRVLRLAPEARGLASSLYL 328
|
330
....*....|....*.
gi 446057161 341 MSMFVFGGIAAPLSGI 356
Cdd:cd17324 329 AAYNLGGALGAALGGL 344
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
12-351 |
8.29e-29 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 114.82 E-value: 8.29e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 12 LGLLAGIGPMCTDLYLPALPE-MSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCA 90
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLlLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 91 TTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEI 170
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAIL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 171 STVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMR---FCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLV 247
Cdd:pfam07690 161 SLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDpvlWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 248 FGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAV 327
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320
|
330 340
....*....|....*....|....
gi 446057161 328 GTQESGTASALMGMSMFVFGGIAA 351
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
21-356 |
3.95e-28 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 113.44 E-value: 3.95e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 21 MCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVV 100
Cdd:cd17325 10 LGYGIIIPILPLYAESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 101 WRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLL 180
Cdd:cd17325 90 ARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 181 FINETLPENKRGSSLLLTGRSVVQNRRFMRFCLIqsFMLAGLFAYIGSSSFV------LQKEFGFNPMQFSLVFGLNGIG 254
Cdd:cd17325 170 LLPEPRPPPNKRAVSAARLRSGLRLLLRDRRLLA--LFLAIFVLAFAFGALEpflplyAAELGGLSPAQIGLLFGAQGLA 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 255 LIIASWIFSRLARRINAMTLLRGGLiaaILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGT 334
Cdd:cd17325 248 SALSQPPAGKLSDRIGRKPLILIGL---LLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGT 324
|
330 340
....*....|....*....|..
gi 446057161 335 ASALMGMSMFVFGGIAAPLSGI 356
Cdd:cd17325 325 AMGLFNTAFSLGMVLGPLLGGF 346
|
|
| PRK10473 |
PRK10473 |
MdtL family multidrug efflux MFS transporter; |
1-368 |
3.32e-26 |
|
MdtL family multidrug efflux MFS transporter;
Pssm-ID: 182486 [Multi-domain] Cd Length: 392 Bit Score: 108.57 E-value: 3.32e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 1 MARVSL-SWALILGLLAGIgpmctDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSL 79
Cdd:PRK10473 1 MSRFLLcSFALVLLYPAGI-----DMYLVGLPRIAADLNASEAQLHIAFSVYLAGMAAAMLFAGKIADRSGRKPVAIPGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 80 LLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFD 159
Cdd:PRK10473 76 ALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAFAILRDTLDDRRRAKVLSLLNGITCIIPVLAPVLGHLIMLKFP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 160 WRTLFWVMAEISTVLLLGCLLFINETLP-ENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFG 238
Cdd:PRK10473 156 WQSLFYTMAAMGILVLLLSLFILKETRPaRAPAASSKPRENSESLLNRFFLSRLVITTLSVTVILTFVNTSPVLLMEQMG 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 239 FNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIaAILCALLTVLCAWIQlpipalVALFFTIAFCSGIGTV 318
Cdd:PRK10473 236 FSRGEYAIIMALTAGVSMTVSFSTPFALGIFKPRTLMLTSQV-LFLAAGITLALSPSH------AVSLFGITLICAGFSV 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446057161 319 GGAEAMS-AVG--TQESGTASALMGMSMFVFGGIAAPLSGIGGETLLKMSLAI 368
Cdd:PRK10473 309 GFGVAMSqALGpfSLRAGVASSTLGIAQVCGSSLWIWLAAVLGISAWNMLIGI 361
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
10-265 |
1.41e-25 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 106.51 E-value: 1.41e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 10 LILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILC 89
Cdd:cd17323 2 FIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGC 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 90 ATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAE 169
Cdd:cd17323 82 ALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLGWRWIFWFLAI 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 170 ISTVLLLGCLLFINETLpenkrgssllltgrsvvqnrrfmRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:cd17323 162 ISGFCLILIFLFLPIVL-----------------------LLGLYVGLVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYL 218
|
250
....*....|....*.
gi 446057161 250 LNGIGLIIASWIFSRL 265
Cdd:cd17323 219 PIGIGALIGSIIGGRL 234
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
27-355 |
3.49e-25 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 104.95 E-value: 3.49e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 27 LPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQG 106
Cdd:cd17321 16 NVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 107 IAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCllfinetl 186
Cdd:cd17321 96 IGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLLA-------- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 187 penkrgssllltgrsvvqnRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLA 266
Cdd:cd17321 168 -------------------RTFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLA 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 267 RRINAMTLLRGGLiaaILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGA---EAMSAVGTQESGTASALMGMSM 343
Cdd:cd17321 229 DRFGPRLVLVAGL---LLTAVGLLLLALLGADSSVWLLLPGLVLLGLGLGLFATPltnAALSSVPKEKAGAASGILNTAR 305
|
330
....*....|..
gi 446057161 344 FVFGGIAAPLSG 355
Cdd:cd17321 306 QLGGALGVALLG 317
|
|
| PRK15402 |
PRK15402 |
MdfA family multidrug efflux MFS transporter; |
52-347 |
3.96e-24 |
|
MdfA family multidrug efflux MFS transporter;
Pssm-ID: 185300 [Multi-domain] Cd Length: 406 Bit Score: 102.71 E-value: 3.96e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQ 131
Cdd:PRK15402 58 LAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIGLCFIGAVGYAAIQESFEEADAIK 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 132 FFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSLLLTGR---SVVQNRRF 208
Cdd:PRK15402 138 ITALMANVALLAPLLGPLVGAALIHVLPWRGMFVLFAALAALSFFGLWRAMPETAGRVGEKLSLKELGRdykLVLKNRRF 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 209 MRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSL----VFGlngiGLIIASWIFSRLARRINAMTLLRGGLIAAIL 284
Cdd:PRK15402 218 VAGALALGLVSLPLLAWIALSPVILISGEQLSSYEYGLlqvpVFG----ALIAGNLTLARLTSRRPLRSLIRMGLWPMVA 293
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446057161 285 CALLTVLCAWIQ-LPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGM-SMFVFG 347
Cdd:PRK15402 294 GLLLAALATVISsHAYLWLTAGLSLYAFGIGLANAGLYRLTLFSSDVSKGTVSAAMGMlSMLIFT 358
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
10-380 |
8.59e-24 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 101.50 E-value: 8.59e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 10 LILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILC 89
Cdd:COG2223 8 LLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 90 ATTNNIYWLVVWRFIQGIAGAGG-----SVLSRSIARDKyQGVtltqFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLF 164
Cdd:COG2223 88 ALAVSYWLLLLLGLLLGIGGGGSfavgiALVSKWFPPDR-RGL----ALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAF 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 165 WVMAEISTVLLLGCLLFINETLPENKRGS-SLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQ 243
Cdd:COG2223 163 LILGILLLVVAVLAWLFLRDPPAGAAAAAkASLRDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAAT 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 244 FSLVFGLNGIGLIIASWIFSRLARRINAMTLLrggLIAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEA 323
Cdd:COG2223 243 AGLLAALFALLGALGRPLGGWLSDRIGGRRVL---LIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFAL 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 324 MSAV-GTQESGTASALMGMSMFVFGGIAAPLSGIGGETLLKMSLAITVCYTLALLVAL 380
Cdd:COG2223 320 VPDIfPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTAAFLVFAVLALVALV 377
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
29-356 |
3.66e-23 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 99.17 E-value: 3.66e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 29 ALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA 108
Cdd:COG2271 32 AAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 109 GAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGcllfinetlpe 188
Cdd:COG2271 112 EAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALL----------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 189 nkrgssllltgrsvvqnrRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARR 268
Cdd:COG2271 181 ------------------RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDR 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 269 INAMTLlRGGLIAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFVFGG 348
Cdd:COG2271 243 LGRRRK-LVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGA 321
|
....*...
gi 446057161 349 IAAPLSGI 356
Cdd:COG2271 322 LGPLLVGY 329
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
10-291 |
3.74e-22 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 95.26 E-value: 3.74e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 10 LILGLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILC 89
Cdd:COG0477 17 LALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLC 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 90 ATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAE 169
Cdd:COG0477 97 GLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAP 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 170 ISTVLLLGCLLfinetLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:COG0477 177 LGLLALVLRLR-----LPESRGLLLALLALALAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALL 251
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446057161 250 LNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVL 291
Cdd:COG0477 252 LLLALLLLAALLLLLLLLLLLALLLALLLLLLLLLLLLLLAL 293
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
60-353 |
7.11e-22 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 95.72 E-value: 7.11e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTV 139
Cdd:cd17473 53 PLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQSAA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 140 NGLAPVLSPVLGGYIVStFDWRTLFWVMAeISTVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFML 219
Cdd:cd17473 133 MSLGGVVFLLLGGALAE-IGWRAPFLVYL-LALPVLILVLLFLPEPARKSKSAASPGAATAAALPWKRVLPIYFLAFLAM 210
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 220 AGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLrggLIAAILCALLTVLCAWIQLPI 299
Cdd:cd17473 211 LLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLL---AIGFALMALGFLLLALASGLW 287
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 446057161 300 PALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFvFGGIAAPL 353
Cdd:cd17473 288 VVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFF-LGQFLSPL 340
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
52-356 |
8.94e-21 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 92.64 E-value: 8.94e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQ 131
Cdd:cd17503 41 LLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGA 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 132 FFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFinetlpenkrgsSLlltgrSVVQNRRFMRF 211
Cdd:cd17503 121 AMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYINLPIGILALLLAPLL------------DL-----RLFKDRNFTLG 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 212 CLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLiaaILCALLTVL 291
Cdd:cd17503 184 LLLSFLLGLGLFGAMFLLPLYLQNVLGYSAFESGLVLAPGGLASAILSPLVGRLLDKFGPRLLLLAGL---LLLALGTLL 260
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 292 CAWIQLPIPALVALFFTIAFCSGIGTV---GGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSGI 356
Cdd:cd17503 261 LAFLTPDTSLWLIILPLFIRGLGMGLVfmpLNTLALNSLPPEQIGDATALFNTIRQLGGSIGTALLAT 328
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
21-380 |
1.58e-19 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 89.02 E-value: 1.58e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 21 MCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVV 100
Cdd:cd06174 10 LARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 101 WRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVS--TFDWRTLFWVMAEISTVLLLGC 178
Cdd:cd06174 90 GRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILL 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 179 LLFINETLPENKRGSSLLLTG------RSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNG 252
Cdd:cd06174 170 LLVVPDPPESARAKNEEASSKsvlkllKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFG 249
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 253 IGLIIASWIFSRLARR-INAMTLLRGGLIAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTqe 331
Cdd:cd06174 250 LAGALGSLLLGLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIR-- 327
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446057161 332 sGTASALMGMSMFVFGGIAAPLSGIGGETLLKMSLAITVCYTLALLVAL 380
Cdd:cd06174 328 -GTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
|
|
| MFS_YajR_like |
cd17472 |
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ... |
52-308 |
1.94e-19 |
|
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341025 [Multi-domain] Cd Length: 371 Bit Score: 88.81 E-value: 1.94e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVG---------QLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGiAGAGGSVLSRSIArD 122
Cdd:cd17472 33 LIGLALGiygltqaifQIPFGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQG-SGAISSVVMALLA-D 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 123 KYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSLLLTGRSV 202
Cdd:cd17472 111 LTREENRTKAMALIGASIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPDPPKIVQISEKEKKKLKKL 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 203 VQNRRFMRFCL---IQSFMLAGLFAYIgssSFVLQKEFGFNPMQFsLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGL 279
Cdd:cd17472 191 LKNKRLLRLDFsifILHFVLMAFFYIL---PLLLTQLGGGKGQLW-KVYLPAILIGFILMVPFVIYAEKKGKMKQVFVSS 266
|
250 260 270
....*....|....*....|....*....|
gi 446057161 280 IAAILCALLTVLCAWIQLP-IPALVALFFT 308
Cdd:cd17472 267 ILLIAVGFLLLLFAATSLWlLIIGLIIFFI 296
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
25-355 |
7.24e-19 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 86.86 E-value: 7.24e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 25 LYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFI 104
Cdd:cd17504 14 MLSPALPTIQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRAL 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 105 QGIAGAgGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFine 184
Cdd:cd17504 94 QGIGGA-VFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAALVPLI--- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 185 tlpenkrgssllltGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQ----KEFGFNPMQFSLVFGLNGIGLIIASW 260
Cdd:cd17504 170 --------------DLRLLRRRNVLLANITALLAGFGMFMVFQLLPQLLQlptpTGFGLGITEAGLLLLPGALVMLIAGP 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 261 IFSRLARRINAMTLLRGGLIAAILCALLTVLCAWIQLPIPALVALF---FTIAFCSGIGTVggaeaMSAVGTQESGTASA 337
Cdd:cd17504 236 LAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIgigLGLAFASLPNIV-----VESVPPDRTGIATG 310
|
330
....*....|....*...
gi 446057161 338 LMGMSMFVFGGIAAPLSG 355
Cdd:cd17504 311 MNTVLRTIGSAIGPAIAG 328
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
21-380 |
1.44e-18 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 86.45 E-value: 1.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 21 MCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVV 100
Cdd:COG0738 22 FATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLL 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 101 WRFIQGIAGAGGSVLSRSIARDKYQGvTLTQFFALLMTVNGLAPVLSPVLGGYIVS---TFDWRTLFWVMAEISTVLLLG 177
Cdd:COG0738 102 ALFLLGLGLGLLDVAANPYVAALGPE-TAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLALL 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 178 CLLF-INETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLI 256
Cdd:COG0738 181 FLRSkLPEIEEEEEEAAGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMT 260
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 257 IASWIFSRLARRINAMTLLRGGLIAAILCALLTVLCAWIQLPIPALVALFFtiaFCSGIGTVGGAEAMSAVGTQESGTAS 336
Cdd:COG0738 261 IGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAPGPWLALIGLALVGL---GLSLMFPTIFSLALDGLGKRTAAAVS 337
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 446057161 337 ALMGMSMFVFGGIAAPLSGIGGETLLKMSLAI-TVCYTLALLVAL 380
Cdd:COG0738 338 AVLIMGIVGGAIGPPLIGFLADAFGLRAAFLVpLVCYLLILLLAL 382
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
14-355 |
1.45e-18 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 86.09 E-value: 1.45e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 14 LLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGlGVGQLLFGP----LSDKIGRKRPLILSLLLFIVSSILC 89
Cdd:cd17330 3 LVVFLDALGFGIVFPVLPFYVREFNKLGASGYYVGLLQSSY-SLGQFLASPlwgrLSDRYGRKPVLLLSLAGSAVSYVLL 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 90 ATTNNIYWLVVWRFIQGIAGAGGSVlSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAE 169
Cdd:cd17330 82 GLSRNLWLLFLARFLDGLTGGNVSV-AQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 170 ISTVLLLGCLLFInetlpenkrgssllltgrsvvqnRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:cd17330 161 LALLNLVLVLFFL-----------------------PPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLA 217
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 250 LNGIGLIIASW-IFSRLARRINAMTLLRGGLIAAIlCALLTVLCAWIQlpiPALVALFFTIAFCSGIGTVG-GAEAMSAV 327
Cdd:cd17330 218 LVGIAGILAQLlLIPRLAKRLGERKLLRLGLLLAI-IGLLLLPFASSV---PLLVLAAAILAFGTGIVFPAlSALLSKSV 293
|
330 340 350
....*....|....*....|....*....|
gi 446057161 328 GTQESGTAsalMGMSMFV--FGGIAAPLSG 355
Cdd:cd17330 294 PSKEQGKA---QGIIQSLqsLARIIGPLLA 320
|
|
| 2_A_01_02 |
TIGR00880 |
Multidrug resistance protein; |
52-185 |
4.11e-18 |
|
Multidrug resistance protein;
Pssm-ID: 273318 [Multi-domain] Cd Length: 141 Bit Score: 80.00 E-value: 4.11e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLS----DKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGV 127
Cdd:TIGR00880 4 LAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIYPPE 83
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 128 TLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINET 185
Cdd:TIGR00880 84 ERGVALGLMSAGIALGPLLGPPLGGVLAQFLGWRAPFLFLAILALAAFILLAFLLPET 141
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
57-356 |
6.90e-16 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 78.79 E-value: 6.90e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 57 VGQLLFGPLSD----KIGRKRPLIL-SLLLFIVSSILCAT------TNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQ 125
Cdd:COG2211 61 ITDPLIGALSDrtrtRWGRRRPWILiGAIPLALSFVLLFTapdlspTGKLIYALVTYLLLGLAYTLVNIPYSALGAELTP 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 126 GVTL-TQFFALLMTVNGLAPVLSPVLGGYIVSTFD------WRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSLLLT 198
Cdd:COG2211 141 DYEErTRLSSWRFAFAGLGGLLASVLPPPLVAAFGgdaalgYRLTALIFAVLGLLAFLLTFFGTKERPVPEEEKVSLKES 220
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 199 GRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGG 278
Cdd:COG2211 221 LKALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIG 300
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 279 LIAAILCALLTVLCAwiqlpiPALVALFFTIAFCSGIGTVGGAEAMSAV------------GTQESGTASALMGMSMFVF 346
Cdd:COG2211 301 LLLAALGLLLLFFLG------PGNLWLLLVLAALAGIGLGAILVLPWAMladvvdydewktGRRREGLYFGIFTFAIKLG 374
|
330
....*....|
gi 446057161 347 GGIAAPLSGI 356
Cdd:COG2211 375 QALAGALAGL 384
|
|
| MFS_Azr1_MDR_like |
cd17502 |
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ... |
52-166 |
5.44e-15 |
|
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341045 [Multi-domain] Cd Length: 337 Bit Score: 75.29 E-value: 5.44e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQ 131
Cdd:cd17502 40 LLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMSLAFIIIADLVPPRERGK 119
|
90 100 110
....*....|....*....|....*....|....*
gi 446057161 132 FFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWV 166
Cdd:cd17502 120 YQGYIGAVFGIASVAGPLIGGAFTDHLSWRWCFYI 154
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
52-355 |
8.66e-15 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 75.09 E-value: 8.66e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIaGAGG-----SVLSRSIARDKYQG 126
Cdd:TIGR00895 62 LIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGL-GLGGlmpnlNALVSEYAPKRFRG 140
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 127 VTLTQFF---ALLMTVNGLapvlspvLGGYIVSTFDWRTLFWVMAEISTVLLL-------------------GCLLFINE 184
Cdd:TIGR00895 141 TAVGLMFcgyPIGAAVGGF-------LAGWLIPVFGWRSLFYVGGIAPLLLLLllmrflpesidflvskrpeTVRRIVNA 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 185 TLPENKRGSSLLL--------TGRSVVQ-------NRRFMRFCLIQSFMLAGLFAyIGSSSFVLQKEFGFNPMQFSLVFG 249
Cdd:TIGR00895 214 IAPQMQAEAQSALpeqkstqgTKRSVFKalfqgktARITVLLWLLYFMLLVGVYF-LTNWLPKLMVELGFSLSLAATGGA 292
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 250 LNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLtvlcaWIQLPIPALVALFFTIA-FCSGIGTVGGAEAMS-AV 327
Cdd:TIGR00895 293 LFNFGGVIGSIIFGWLADRLGPRVTALLLLLGAVFAVLV-----GSTLFSPTLLLLLGAIAgFFVNGGQSGLYALMAlFY 367
|
330 340
....*....|....*....|....*...
gi 446057161 328 GTQESGTASALMgMSMFVFGGIAAPLSG 355
Cdd:TIGR00895 368 PTAIRATGVGWA-IGIGRLGAIIGPILA 394
|
|
| MFS_XylE_like |
cd17359 |
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ... |
52-314 |
1.99e-14 |
|
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340917 [Multi-domain] Cd Length: 383 Bit Score: 74.14 E-value: 1.99e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLS----RSIARDKYQG- 126
Cdd:cd17359 46 LLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASALVpmyiAEVAPAEIRGr 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 127 -VTLTQffalLMTVNGLAPV------LSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLlfineTLPENKRgsSLLLTG 199
Cdd:cd17359 126 lVSLNQ----LMIVFGQLLAyivnylIANAGGADWLGAEGWRWMLGLEAIPAILFLLGML-----FIPESPR--WLVSKG 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 200 RSVVqnrrFMRFCL--IQSFMLAGLFAYIGSSSFvlqKEFGFNP----MQFSLVFGLNGIGLIIASWIFSRLARRinamT 273
Cdd:cd17359 195 KPIL----IIGIGLaiFQQFVGINVIFYYGPEIF---QNAGFSEnaalLQTIGIGVVNVIFTIIAILLVDKVGRK----P 263
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446057161 274 LLRGGLIAAILCALLTVLCAWI-----QLPIPALVALFFTIAFCSG 314
Cdd:cd17359 264 LLLIGSIGMAISLLLIGTAFYFapgsqASGIVALVLILLFVAFFAM 309
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
51-317 |
4.77e-14 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 72.63 E-value: 4.77e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA----GAGGSVLSRSIARDKYQG 126
Cdd:cd17316 45 GFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGiggeYPGASTYVAEFAPSKRRG 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 127 VTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAeistvLLLGCLLFInetlpenkRGSSLLLTGrsvvqnr 206
Cdd:cd17316 125 FALGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGA-----LPALLALLL--------RRRTLLLIL------- 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 207 rfmrFCLIQSFMLAGLFAYIGSssfVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCA 286
Cdd:cd17316 185 ----LWFFISFGYYGLTTFLPT---YLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILA 257
|
250 260 270
....*....|....*....|....*....|.
gi 446057161 287 LLtvLCAWIQLPIPALVALFFTIAFCSGIGT 317
Cdd:cd17316 258 LP--LFYLLSGSPTLLLLLLFILSFFVGGVW 286
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
29-353 |
1.07e-13 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 71.45 E-value: 1.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 29 ALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA 108
Cdd:cd17319 25 AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 109 GAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFInetlpe 188
Cdd:cd17319 105 EAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLLAVLWWFYL------ 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 189 nkrgssllltgrsvvqnRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLV----FGLNGIGLIIASWI--- 261
Cdd:cd17319 179 -----------------RQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLaaipFLAGAIGMILGGRLsdr 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 262 FSRLARRINAMTLLRGGLIAAILCALLTVlcawiqlPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGM 341
Cdd:cd17319 242 LLRGARRLVIIIGLLLAAVGLLLAYLTTS-------PVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINS 314
|
330
....*....|..
gi 446057161 342 sMFVFGGIAAPL 353
Cdd:cd17319 315 -GGNLGGFVAPL 325
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
57-383 |
6.67e-13 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 69.18 E-value: 6.67e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 57 VGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALL 136
Cdd:cd17329 50 VASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLL 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 137 MTVNGLAPVLSPVLGGYIVsTFDWRTLFWVMAEISTVLLLGCLLFINETLP--ENKRGSSLLLTGRSVVQNRRFMRFCLI 214
Cdd:cd17329 130 YWAINLGVAIGPLLGGLLL-LYSFRLLFLAAAVLFLLAALVLLFLLPETRPkrRAAEKTEILRGYKIVLRDRAFLLFLLA 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 215 QSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLcaw 294
Cdd:cd17329 209 SFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRKILMIGILLFAIGFAVLAF--- 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 295 iqlpIPALVALFFTIAFCSgIGTVGGAEAMSAVGTQESgtASALMGMSMFVF------GGIAAPLSGIGGETLLKMSLAI 368
Cdd:cd17329 286 ----ANTLAVLILAMIVLT-LGEMLVFPAVQTLVAALA--PPDKRGSYMGFYalawglGRAIGPLVGGLLLDLLGPGLPW 358
|
330
....*....|....*
gi 446057161 369 TVCYTLALLVALTRI 383
Cdd:cd17329 359 LILAALGLIAAALLL 373
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
59-305 |
8.44e-13 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 69.20 E-value: 8.44e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 59 QLLFGP----LSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIArDKYQGVTLTQFFA 134
Cdd:cd17388 51 QFIFAPilgaLSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIA-DVTPPEQRARNFG 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 135 LLMTVNGLAPVLSPVLGGyIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSL---LLTGRSVVQNRRF--M 209
Cdd:cd17388 130 LLGAAFGLGFIAGPALGG-LLGEISPRAPFLVAAGLNGLNFLLGLFVLPESLPPERRRAFRwrrANPFGSLRWLTGFpgL 208
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 210 RFcLIQSFMLAGLFAYIGSSSFVL--QKEFGFNPMQFSLVFGLNGIGLIIA-SWIFSRLARRINAMTLLRGGLIAAILCA 286
Cdd:cd17388 209 LG-LLAVFFLIQLIGQVPATTWVLftEDRFDWSPTMVGLSLAVFGLLHALFqAFVTGPIAKRLGEKRAILLGLAADALGF 287
|
250 260
....*....|....*....|.
gi 446057161 287 LLTVLC--AWIQLPIPALVAL 305
Cdd:cd17388 288 LLLAFAtqGWMVFPILILLAL 308
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
51-355 |
8.80e-13 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 68.77 E-value: 8.80e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIaGAGGSVLSR-SIARDKYQGVTL 129
Cdd:cd17365 43 ALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTGL-GLGAAMPNAiTLVSEYAPARRR 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 130 TQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAeistVLLLGCLLFInetlpenkrGSSLLLTGrsvvqnrrfm 209
Cdd:cd17365 122 SLAVTLMFCGYPLGAALGGFLAAALIPAFGWRSVFLLGG----VPPLILLPLL---------RGTLLLWV---------- 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 210 rfcliQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLrggliaaILCALLT 289
Cdd:cd17365 179 -----TFFMGLLLVYLLNSWLPKLMVEAGYSLSQALTITLLLNIGGVIGSLLLGWLADRFGPKRVL-------ALFFALG 246
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 290 VLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMS----MFVFGGIAAPLSG 355
Cdd:cd17365 247 AVSLALLGVSPASLVLLYVLVFLAGACVNGAQVGLYALAARFYPTEVRATGVGwalgVGRLGAILGPLLG 316
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
52-315 |
8.44e-12 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 66.17 E-value: 8.44e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG----GSVLSRSIARDKYQGV 127
Cdd:cd17371 44 LAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALAGLGFGGewaaGAALMAEYVPARHRGK 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 128 TLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVlllgcLLFINETLPE--------NKRGSSLLLTG 199
Cdd:cd17371 124 ALGYVQSGWAVGWLLATLLAALLFPLLPPEIAWRVLFLLGALPALL-----VLFIRRFVKEppqwqaarAARRHFADRPS 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 200 RSVVQNRRFMRFCLIQSFMLAG-LFAYIGSSSFV---LQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLL 275
Cdd:cd17371 199 LRELFSPPLLRTTLLASLLATGaLGGYYGITTWLpsyLTGERGLSFEGSAGYLVVTILGGFLGYLAGGFLADRIGRRNNF 278
|
250 260 270 280
....*....|....*....|....*....|....*....|
gi 446057161 276 rggLIAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGI 315
Cdd:cd17371 279 ---ALFALGSAISILLYFFLPLSPTLILILGFPLGFFASG 315
|
|
| PRK15403 |
PRK15403 |
multidrug efflux MFS transporter MdtM; |
59-267 |
1.20e-11 |
|
multidrug efflux MFS transporter MdtM;
Pssm-ID: 237958 [Multi-domain] Cd Length: 413 Bit Score: 65.62 E-value: 1.20e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 59 QLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFALLMT 138
Cdd:PRK15403 68 QWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFIATVGYVTVQEAFGQTKGIKLMAIITS 147
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 139 VNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRG---SSLLLTGRSVVQNRRFMRFCLIQ 215
Cdd:PRK15403 148 IVLVAPIIGPLSGAALMHFVHWKVLFAIIAVMGLIAFVGLLLAMPETVKRGAVPfsaKSVLRDFRNVFRNRLFLTGAATL 227
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 446057161 216 SFMLAGLFAYIGSSSFVLQKEFGFNPMQFSL----VFGlngiGLIIASWIFSRLAR 267
Cdd:PRK15403 228 SLSYIPMMSWVAVSPVILIDAGGMTTSQFAWtqvpVFG----AVIVANAIVARFVK 279
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
28-356 |
1.42e-11 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 65.28 E-value: 1.42e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 28 PALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGI 107
Cdd:COG2807 39 PLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 108 AGAGGSVLSRSIARDKYQGvTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETlP 187
Cdd:COG2807 119 GIAVGNVLLPGLIKRWFPD-RVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRRR-P 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 188 ENKRGSSLLLTGRSVVQNRRFMRFCL---IQSFMLAGLFAYIGSssfVLQkEFGFNPMQFSLVFGLNGIGLIIASWIFSR 264
Cdd:COG2807 197 AAAAAAPAAASLRSLWRSPLAWLLTLffgLQSLLYYAVVAWLPP---ILR-DAGLSAATAGLLLSLFQLAGIPGSLLVPL 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 265 LARRINAMTLLrgGLIAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMF 344
Cdd:COG2807 273 LADRLGDRRPL--LLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRARTPAEAAALSGMAQSVGY 350
|
330
....*....|..
gi 446057161 345 VFGGIAAPLSGI 356
Cdd:COG2807 351 LLAALGPLLVGA 362
|
|
| MFS_GLUT6_8_Class3_like |
cd17358 |
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ... |
51-185 |
1.71e-11 |
|
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340916 [Multi-domain] Cd Length: 436 Bit Score: 65.29 E-value: 1.71e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLG--VGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGS----VLSRSIARDKY 124
Cdd:cd17358 48 SLLTLGalIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFLAGFGGGAASvvvpVYIAEIAPKNV 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446057161 125 QGvTLTQFFALLMTVNglapvlspVLGGYIVSTF-DWRTLFWVmAEISTVLLLGCLLFINET 185
Cdd:cd17358 128 RG-ALGSLNQLLVNIG--------ILLGYVLGSFlPWRTLALI-GAIPPVVFLILLFFIPES 179
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
57-383 |
2.16e-11 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 64.56 E-value: 2.16e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 57 VGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVW-----RFIQGIAGAGGSVLSRSIARDKYQGVTLTQ 131
Cdd:cd06173 49 LFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWlllvlAFLLGIASAFFGPARQALLPELVPKEQLVR 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 132 FFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAeISTVLLLGCLLFINETLPENKRGSSLLLT------GRSVVQN 205
Cdd:cd06173 129 ANALNSLATQLARIIGPALGGLLVALLGPGGAFAINA-LSFLLSALLLLFIRRPPPAAPGESSSLLLrdlregLRYLRRS 207
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 206 RRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINamtLLRGGLIAAILC 285
Cdd:cd06173 208 PLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR---RGRLLLIGALLL 284
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 286 ALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSGIGGETL-LKM 364
Cdd:cd06173 285 GLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALgLSA 364
|
330
....*....|....*....
gi 446057161 365 SLAITVCYTLALLVALTRI 383
Cdd:cd06173 365 VFLLAGALLLLAALLLLLL 383
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
53-356 |
3.11e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.15 E-value: 3.11e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQF 132
Cdd:cd17489 42 LAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEG 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 133 FALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEIStVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMRFC 212
Cdd:cd17489 122 IGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLA-LLALLLVFLVKDPPPVAAEEAEAGTRAFRRLVEKKVLPPA 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 213 LIqsfMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRinamtllRGGLIAAILCALLTVLC 292
Cdd:cd17489 201 LI---LFLASIAYGAISTFLPLYAAERGISNAGLFFTVYAIALLLSRPFSGKLSDR-------KGPKTVIIPGLLLLALG 270
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446057161 293 AWIQLPIPALvALFFTIAFCSGIGT-----VGGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSGI 356
Cdd:cd17489 271 LLLLSFAGSP-WMLLLAAVLYGLGFgllfpALQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLGL 338
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
53-376 |
5.88e-11 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 63.35 E-value: 5.88e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRS----IARDKYQGvt 128
Cdd:cd17477 42 LGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSESwlnaLATNENRG-- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 129 ltQFFALLMTVNGLAPVLSPVLGGyIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSLLLTGRSvvqnrrf 208
Cdd:cd17477 120 --RVLGLYSTVLGLGFALGPLLLA-LVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESISLRRLLRI------- 189
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 209 MRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALL 288
Cdd:cd17477 190 APLALLGAFVAGFLEGAFYSLLPLYGLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALL 269
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 289 TVLcaWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMsMFVFGGIAAPLSG------IGGETLL 362
Cdd:cd17477 270 LPL--VPGLPLALLVLLFLWGGAAGPLYTLALALAGDRLPGDELVAANAALLL-LYGLGSVIGPLLAgalmdaFGPHGLF 346
|
330
....*....|....
gi 446057161 363 KMSLAITVCYTLAL 376
Cdd:cd17477 347 LFLAAVALLFLLFL 360
|
|
| efflux_EmrB |
TIGR00711 |
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ... |
52-191 |
8.09e-11 |
|
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]
Pssm-ID: 129794 [Multi-domain] Cd Length: 485 Bit Score: 63.17 E-value: 8.09e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKY---QGVT 128
Cdd:TIGR00711 47 MLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPLIPLSFSTLLNIYppeKRGR 126
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446057161 129 LTQFFALLMTVnglAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKR 191
Cdd:TIGR00711 127 AMAIWGLTVLV---APALGPTLGGWIIENYHWRWIFLINVPIGIIVVVVAFFILPRDKPAASE 186
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
51-354 |
1.28e-10 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 62.18 E-value: 1.28e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLfGPLSDKIG-RKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIqgIAGAGGSV------LSRSIArDK 123
Cdd:cd17471 42 ALSGIVVSQWL-GRLSDRGGdRKPLILLALLAGALGYLLFAFLRNYWVLLLVGVV--LLSLGAAAfpqlfaLAREYA-DR 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 124 YQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFInETLPENKRGSSLLLTGRSVV 203
Cdd:cd17471 118 SSGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLL-PSVKPPAQKATPASSLVKAP 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 204 QNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAI 283
Cdd:cd17471 197 VNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRLLLAGFLAGV 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 284 L-CALLTVLCAWIQLpIPALVALFFTIAFCSGIGTVGGAEAMsavgTQESGTASAL--------MGMSMFVFGGIAAPLS 354
Cdd:cd17471 277 LfYLGLALATSLWQL-IALQLLNAIFIGITAGLGISYFQDLM----PGQPGLATTLysnasrigSLLGGLLAGVIAQYFG 351
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
52-353 |
2.85e-09 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 58.40 E-value: 2.85e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQ 131
Cdd:cd17328 44 IISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTR 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 132 FFALLMTVNGLAPVLSPVLGGYIVS-TFDWRTLFWVMAEIStvLLLGCLLFIneTLPENKRG------------SSLLLT 198
Cdd:cd17328 124 ALGVFYFAIPLGSGLGYVVGGLVAQaTGGWRWAFRVTGVLG--VLLAILLLL--FVREPPRGaaeggvmakstaTSFLAD 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 199 GRSVVQNRRFMRFCL---IQSFMLAGLFAYIGSssfVLQKEFGFNPMQ---FSLVFGL-NGIGLIIASWIFSRLARRINA 271
Cdd:cd17328 200 LKALAKNPSFILSTLgftAVSFVTGALAFWAPT---FFLRAFGVGDLSsadVGLIFGAiTCIAGVLGVLLGGILADRLRR 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 272 MT------LLRGGLIAAILCALLTVLCAWIQlPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFV 345
Cdd:cd17328 277 KTpradplVCAVGLLAAAPFLFLALVLALSN-LLLAWVLLFLGEFLLSLNWAPVFAILLYVVIPTRRSTASAIQILLSHL 355
|
....*...
gi 446057161 346 FGGIAAPL 353
Cdd:cd17328 356 LGDAGSPY 363
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
54-318 |
5.27e-09 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 57.28 E-value: 5.27e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 54 GLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLS----RSIARDKYQGvtl 129
Cdd:cd17360 47 GAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVplyiAEAAPPRIRG--- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 130 tqffaLLMTVNGLA----PVLSPVLGGYIVSTFD-WRTLFWVMAeISTVLLLGCLLFINET--LPENKRGsslLLTGrsv 202
Cdd:cd17360 124 -----RLVTINVLFitggQFVAYVINGAFSYLPGgWRWMLGLAA-VPAVLQFIGLLFLPESprWPSTRRA---LIVG--- 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 203 vqnrrfmrfCLIQSF-MLAGLFAYIGSSSFVLQKeFGFNPMQFSL-----VFGLNGIGLIIASWIFSRLARRINAMTLLR 276
Cdd:cd17360 192 ---------CGLQAFqQFSGINTVMYYSATILQM-AGFKDNQNAIwlsliVAGTNFIFTIVGMYLIDKFGRRKLLLISLF 261
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446057161 277 GGLIAAILCALLTVLCAWIqlpipalvalFFTIAFCSGIGTV 318
Cdd:cd17360 262 GVIVALVVLAVWLALVGLI----------LYLAFFAPGMGPV 293
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
21-381 |
1.22e-08 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 56.03 E-value: 1.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 21 MCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVV 100
Cdd:cd17478 10 FYQGFLPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLL 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 101 WRFIQGIAGAG----GSVLSRSIARDKyqgvtLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLL 176
Cdd:cd17478 90 LVALAGIGSAAfhpeGARLASQAAGGR-----RGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIIPGLAVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 177 GCLLFINETLPENKRGSSLLLTGRSVVQNRRFMR----FCLIQSFMLAGLFAYIGsssfVLQKEFGFNPMQFSLVFGLNG 252
Cdd:cd17478 165 LLLRLRPLKKPEAKKAAAKSSARSTLKGVWRALLllliIVFLRSWVLSSLTTFLP----FYLVQRGYSLVFAGLLLSLFL 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 253 IGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVLcAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSavgtQES 332
Cdd:cd17478 241 FAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLL-TPGIWSYILLVLAGFLLFASFPVTVVLAQELLP----GNV 315
|
330 340 350 360
....*....|....*....|....*....|....*....|....*....
gi 446057161 333 GTASALMGMSMFVFGGIAAPLSGIGGETLLkMSLAITVCYTLALLVALT 381
Cdd:cd17478 316 GLASGLMMGLSFGLGGIGAPVLGALADAFG-LESVLLILALLPLLGALL 363
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
56-317 |
2.10e-08 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 55.30 E-value: 2.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 56 GVGQLLF----GPLSDKIGRKRPLILSLLLF-IVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIArDKYQGVTLT 130
Cdd:cd17490 41 GISQMLLriplGILSDRIGKRKLFIIIGLLFtVLASLIMILFPSPWGLLIARFLSGIAAATWVSFTVLYA-SYFPPDEAA 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 131 QFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWvMAEISTVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMR 210
Cdd:cd17490 120 KAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFL-LAALAGVLGFILSLFIKEERREKKPVLTELKELLSVLKDKKLLF 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 211 FCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLV----FGLNGIGLIIASWIFSRLARRINAMTLlrGGLIAAILCA 286
Cdd:cd17490 199 FSLLAILQQMITFSTTFGFTPLIAKQLGASSFQLGLLsiiyLLPNALASLLSGTLFYKKLGERNTIII--GFLLLGAYCF 276
|
250 260 270
....*....|....*....|....*....|.
gi 446057161 287 LLTVlcawiqlpIPALVALFFTIAfCSGIGT 317
Cdd:cd17490 277 LIPF--------APNLTLLYLLQA-LNGFGT 298
|
|
| MFS_OAT |
cd17374 |
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ... |
52-359 |
2.56e-08 |
|
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340932 [Multi-domain] Cd Length: 341 Bit Score: 54.99 E-value: 2.56e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKyqgvTLTQ 131
Cdd:cd17374 45 MAGLLVGALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLILGTEW----TTPR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 132 FFALLMTVNGLA-PVLSPVLGGYIVSTFDWRTLFWVMAeistvllLGCLLFINETLPENKRGSSLLltgrsvvqnrrFMR 210
Cdd:cd17374 121 HRALAITLTSCFfSIGQMLLAGLAYAIRDWRLLQLVVS-------VPFFLFFLYSWWLPKRTLILS-----------FVW 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 211 FcliqsfmlAGLFAYIGSSSFVlqKEFGFNPMQFSLVFGLNGI-GLIIASWIFSRLARRINAMTLLrggliaailcaLLT 289
Cdd:cd17374 183 F--------ANSFSYYGLSLDL--QHLGLNVFLLQFLFGAVEVpARCLALFLLNHMGRRISQAVLL-----------LLA 241
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446057161 290 VLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQE------SGTASALMGMsMFVFGGIAAPLSGIGGE 359
Cdd:cd17374 242 GLCILANIFVPQEMQTLRTVLAVLGKGSSAAAFTISYVYTAElfptvlRQTGMGLNSM-FARIGGILAPLIMLLGV 316
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
13-185 |
3.22e-08 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 54.97 E-value: 3.22e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 13 GLLAGIGPMCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCAT- 91
Cdd:pfam00083 17 GVIGAFLTLIDFFKNFGLSKSVSSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAa 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 92 --TNNIYWLVVWRFIQGIAGAGGSVLSRS----IARDKYQGvTLTQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFW 165
Cdd:pfam00083 97 kgKWSVYQLIVGRVLVGIGVGGASVLAPMyiseIAPKKLRG-ALGSLYQLAITFGILLAYIFGLGLNKTSNSDGWRIPLG 175
|
170 180
....*....|....*....|
gi 446057161 166 VMAeISTVLLLGCLLFINET 185
Cdd:pfam00083 176 LQL-VPALLLIIGLLFLPES 194
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
28-378 |
1.01e-07 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 53.43 E-value: 1.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 28 PALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGI 107
Cdd:cd17312 24 VAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSALANIFMGFSTSLWFFAVLWGLNGL 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 108 A-GAGGSVLSRSIAR---DKYQGVtltqFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFIN 183
Cdd:cd17312 104 FqSMGWPPCVKLLGNwfsKKERGT----VYGIWSTSHNFGGILAPILAASLASYYGWRAAFLVPGIVGLVVAIILFFFLR 179
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 184 ETLPenkrgssllltgrsvvqnrrfmrfcLIQSFMLAGLFAYIGSSSFV------LQKEFGFNPMQFSLVFGLNG----I 253
Cdd:cd17312 180 DSPP-------------------------YVWVLSLAYAFVYIVRYACLdwgplyLYEVKGYSLIDAGWFSSLYEvggiA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 254 GLIIASWIFSRLARRinamtllRGGLIAAILCALLTVLCAWIQL----PIPALVALFFTIAFCSGIGTVGGAEAMSAVGT 329
Cdd:cd17312 235 GTILAGLLSDKLFGG-------RRAPIAVIYMLLMTLSLALFWFfphnKLLSIVLLFLIGFFVGGPINLIGGAAAQDIGR 307
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*
gi 446057161 330 QE-SGTASALMGMSMFVFGGIAAPLSGI-----GGETLLKMSLAITVCYTLALLV 378
Cdd:cd17312 308 KEaAGTATGFVGLFGYLGASLAGLPLGYiidhyGWSTVFYFLISAALLSVLLLLS 362
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
57-355 |
1.18e-07 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 52.99 E-value: 1.18e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 57 VGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWR----FIQGIAGAGGSVLSRSIARDKyqgvtlTQF 132
Cdd:cd17331 50 VGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSRlpsvFMHAMQAAQMVVTDLTDPGER------AAA 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 133 FALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFI---NETLPENKRGSS-------LLLTGRSV 202
Cdd:cd17331 124 LGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIpsnTKSKREKEAKESasppsvfNLKEILRL 203
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 203 VQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIA-SWIFSRLARRINAMTLLRGGLIA 281
Cdd:cd17331 204 LRLPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVLGMVVqGLLVGPLTKRFGERSLLKLSVAL 283
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446057161 282 AILCALLTVLCAwiQLPIPALVALFFTIAFCSgIGTVGGAEAMSAVGTQESGTASALmGMSMFVFGGIAAPLSG 355
Cdd:cd17331 284 LAIGYLLLAFVT--TVWQLLVLLLPLVIGGSV-LYTVITSLLTKAVPPEDTGTALGL-SHALFSLVRTVSPTIG 353
|
|
| MFS_GLUT_like |
cd17315 |
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ... |
51-314 |
1.33e-07 |
|
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340873 [Multi-domain] Cd Length: 365 Bit Score: 52.96 E-value: 1.33e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRS----IARDKYQG 126
Cdd:cd17315 43 LLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLyiseIAPAKIRG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 127 VTLTqfFALLMTVNGLapVLSPVLGGYIVSTF-DWRTLFWVMAEISTVLLLGCLLFINETLPenkrgsslLLTGrsvvqn 205
Cdd:cd17315 123 ALGT--LNQLMITFGI--LLAYLLGLALSLSPpGWWRLMFALAAVPALLQLLLMFFLPESRA--------LLVG------ 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 206 rrfmrfCLIQSFM-LAGLFAYIGSSSFVLQKEFGF-NPMQFSLVFGL-NGIGLIIASWIFSRLARRinamTLLRGGLIAA 282
Cdd:cd17315 185 ------VGLQLLQqLTGINAVMYYAPTIFKSAGGGtASILASIIVGVvNLLATLVAIRLVDKVGRR----PLLLIGFAGM 254
|
250 260 270
....*....|....*....|....*....|....
gi 446057161 283 ILCALLTVLCAWIQLPIPAL--VALFFTIAFCSG 314
Cdd:cd17315 255 AASLLLLAIAFLLPALAKAAgwLALLGILLYIAA 288
|
|
| MFS_TRI12_like |
cd06179 |
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ... |
52-181 |
1.52e-07 |
|
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340868 [Multi-domain] Cd Length: 518 Bit Score: 53.01 E-value: 1.52e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIaGAGGSVLSRSIARD----KYQGV 127
Cdd:cd06179 42 SLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGI-GAGTQGLGAAVASElvpnKYRGL 120
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 446057161 128 TLTQFFALLMTVNGLAPVLSPVLGGYIVSTfdWRTLFWVMAEISTVLLLGCLLF 181
Cdd:cd06179 121 VQGVVNLVASPGSALGPLIAGALVEANAAG--WRWIFYINAIFNALALILLFFF 172
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
51-120 |
3.19e-07 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 51.89 E-value: 3.19e-07
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCAT------TNNIYWLVVWRFIQGIAGAGGSVLSRSIA 120
Cdd:cd17364 48 ALVGTIIGQLFFGFLGDRFGRKRVYGVELIIMIIGTILSALspgstpLGVMGWLIFFRFLLGIGIGGDYPLSATIM 123
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
53-182 |
6.44e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 6.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQF 132
Cdd:cd17325 246 LASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTA 325
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|
gi 446057161 133 FALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFI 182
Cdd:cd17325 326 MGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
52-185 |
7.01e-07 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 50.64 E-value: 7.01e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGR--KRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTL 129
Cdd:COG2271 226 FLAGIVGSLLGGWLSDRLGRrrKLVLAIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKAR 305
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446057161 130 TQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINET 185
Cdd:COG2271 306 GTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLRET 361
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
53-114 |
1.28e-06 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 50.40 E-value: 1.28e-06
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSV 114
Cdd:TIGR00898 138 VGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGIGGIWV 199
|
|
| 2A0109 |
TIGR00887 |
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ... |
51-204 |
2.21e-06 |
|
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]
Pssm-ID: 129965 [Multi-domain] Cd Length: 502 Bit Score: 49.34 E-value: 2.21e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCAT------TNNIYWLVVWRFIQGIAGAGGSVLSRSI----A 120
Cdd:TIGR00887 65 ASIGTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGLspgsspKSVMATLCFWRFWLGVGIGGDYPLSAIItsefA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 121 RDKYQGVTLTQFFAL--LMTVNGlAPVLSPVLGGY----------------IVSTFD--WRTLFWVMAEistvllLGCL- 179
Cdd:TIGR00887 145 TKKWRGAMMAAVFAMqgFGILAG-AIVALIVLAGFkhsleaaadeasctgsCVPAVDymWRILIGFGAV------PALLa 217
|
170 180
....*....|....*....|....*
gi 446057161 180 LFINETLPENKRGSSLLltGRSVVQ 204
Cdd:TIGR00887 218 LYFRLTIPETPRYTADV--AKDVEQ 240
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
53-351 |
3.71e-06 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 48.39 E-value: 3.71e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG-GSVLSRSIAR---DKYQGvt 128
Cdd:cd17475 42 LGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLLFLVGAGYGSvQPGGGRAIMRwfpPRERG-- 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 129 ltqfFALLMTVNG--LAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPEN---KRGSSLLLTGRSVV 203
Cdd:cd17475 120 ----LAMGIRQTGvpLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPAASaatESASTLLRSLKEVL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 204 QNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQ----FSLVFGLNGIGLIIASWIFSRLARRiNAMTLLRGGL 279
Cdd:cd17475 196 RNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVVAagalLAVAQLGGALGRIGLGRVSDRVFGG-RRRPVLVITA 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446057161 280 IAAILCALLTVLCAWiQLPIPALVALFFTI-AFCSGIGTVGGAEAMSAVGTQESGTASALMGmsMFVFGGIAA 351
Cdd:cd17475 275 AIAAAALLVLSLLSP-GTPLWLLVLLLILLgLFAIGWNGLYLTLVAESAGPEQAGTALGLAN--TINFIGIAI 344
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
60-379 |
5.61e-06 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 47.92 E-value: 5.61e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIG-RKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAggsvlSRSIARDK-----YQGVTLTQFF 133
Cdd:cd17370 52 LFSGYLSDRTGkRKPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKG-----IRTPPRDAlladaTPPSGRGKAF 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 134 ALLMTVNGLAPVLSP--VLGGYIVSTFDWRTLFWVMAeISTVLLLGCLLFINETLPENKRGSSLLLTGRSVVQNRRFMRF 211
Cdd:cd17370 127 GLHRALDTLGAVLGPllAALLLYLLGGNYRTIFLLAA-IPALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLY 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 212 CLIQSFMLAGLFAYIGsssFVLQ-KEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLtv 290
Cdd:cd17370 206 LLAVALFALGNFSFAF---LILRaQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLG-- 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 291 lcawIQLPIPALVALFFTIAFCSGIGTVGGAE-AMSAVGTQESGTASAlMGMSMFVFGGIAAPLSGIGGETLLKMSLAIT 369
Cdd:cd17370 281 ----FALGSSLWLLLLGFILWGLYMGAQESIErAAVADLVPAELRGTA-YGLFNTVVGIGWLLASLIAGYLWDLISPSAA 355
|
330
....*....|
gi 446057161 370 VCYTLALLVA 379
Cdd:cd17370 356 FLFSAVLALI 365
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
56-181 |
5.67e-06 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 47.99 E-value: 5.67e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 56 GVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWL-VVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFA 134
Cdd:cd17353 263 GGGRPFWGWLSDKIGRKNTLSIAFLIQGVAMFLLPFIGSVAVLfVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNYG 342
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 446057161 135 LLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLF 181
Cdd:cd17353 343 LLYTAKGVGGLIGPIIAAYVLYTGGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
52-182 |
1.03e-05 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 46.80 E-value: 1.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG----GSVLSRSIARDKYQ-- 125
Cdd:cd17317 35 FLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGiftvGFVLGMEIVGPKYRsf 114
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 126 -GVTLTQFFALLMtvnglapVLSPVLGGYIVstfDWRTLFWVMAeISTVLLLGCLLFI 182
Cdd:cd17317 115 vGILFGLFWALGY-------MLLALLAYLIR---DWRWLQLAIS-LPGLLFLLLLWWL 161
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
56-380 |
1.37e-05 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 46.94 E-value: 1.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 56 GVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQFFAL 135
Cdd:cd17343 52 AISKFIGGVLSDQISARWLFSSGLVLSGLTTVAFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSV 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 136 LMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFI----------NETLPENKRGSSLLLTGRSVVQN 205
Cdd:cd17343 132 LSTSMNLAGSLGPILATLLALSYGWRSTLSISGTVAVVMSVVCLLFIknepsdvglnNIEEEESKGKKKKSPRGESTLKE 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 206 RRFMRFCLIQSFMLAGLF----AYIGSSSFVLQKEFGFNPMQFSLV---FGLNG-IGLIIASWIFSRLARRINA------ 271
Cdd:cd17343 212 LLLSPFLWLLSLGYLVVFgvktAVTDWGQLFLIQDKGQSALTGSSFmssLEVGGfVGSIAAGYLSDWAVAKHGSssrgnp 291
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 272 -MTLLRggLIAAILCALLTVLCAWIQLPIP--ALVALFFTIAFCS-GIGTVGGAEAMSAVGTQESGTASALMGMSMFVFG 347
Cdd:cd17343 292 rMPLAL--VFMAGLTVSLHLFRVHITSDSSelFILLLGFLIGFSLyGPIAIFGVIANESAPSHLCGTSHAIVALAANVGG 369
|
330 340 350
....*....|....*....|....*....|....
gi 446057161 348 GIAA-PLSGIGGETLLKMSLAITVCYTLALLVAL 380
Cdd:cd17343 370 VLAGlPFSYIAKHYDWRTAFLLLEILCAITVVIL 403
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
21-355 |
1.59e-05 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 46.55 E-value: 1.59e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 21 MCTDLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVV 100
Cdd:cd17333 10 LTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 101 WRFIQGIAGAGGSVLSRSIARDKYQGvTLTQFFALLMTVNGLAPVLSPVLGGYIVST-FDWRTLFWVMAeiSTVLLLGCL 179
Cdd:cd17333 90 LMFLAGLGAGILDTGANTFVGALFEE-SSATRLNVLHGFFGLGALIGPLIATSLLTSeLSWSWAYLIIG--LIYLLLAIL 166
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 180 LFINETLPENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFV------LQKEFGFNPMQFSLVFGLNGI 253
Cdd:cd17333 167 ILLTLFPELPSARNPQQSVGAFSASASRLLRNPSIILGALALFLYVGAETAFSswvpsyLVEKKHVSDGLAGYLLSGFWV 246
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 254 GLIIASWIFSRLARRINAMTLLRGGLIAAIlcaLLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGtQESG 333
Cdd:cd17333 247 GITIGRLLGGPISRRIKPHTLLVLSGSGAL---LGLLILLLAPTLVVGLVATALLGLFMAALFPTILSLGISNLP-YAKG 322
|
330 340
....*....|....*....|..
gi 446057161 334 TASALMGMSMFVFGGIAAPLSG 355
Cdd:cd17333 323 KGTSVLLAAGSIGGAIIPFIMG 344
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
51-180 |
1.84e-05 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 46.49 E-value: 1.84e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIaGAGGSV-----LSRSIARDKYQ 125
Cdd:PRK11551 59 GILGLLPGALLGGRLADRIGRKRILIVSVALFGLFSLATAQAWDFPSLLVARLLTGV-GLGGALpnliaLTSEAVGPRLR 137
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446057161 126 GVTLTQFFALLMTVNGLAPVLSPVLGGyivsTFDWRTLFWV--MAEISTVLLLGCLL 180
Cdd:PRK11551 138 GTAVSLMYCGVPFGGALASVIGVLAAG----DAAWRHIFYVggVGPLLLVPLLMRWL 190
|
|
| MFS_SLC22A1_2_3 |
cd17379 |
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ... |
53-146 |
2.08e-05 |
|
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340937 [Multi-domain] Cd Length: 340 Bit Score: 46.19 E-value: 2.08e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG----GSVLSRSIARDKYQ--- 125
Cdd:cd17379 44 LGFLIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLFGKGgwmtGYVLVTEFVGSKYRrtv 123
|
90 100
....*....|....*....|..
gi 446057161 126 GVTLTQFFAL-LMTVNGLAPVL 146
Cdd:cd17379 124 GIVYQMFFTLgLLILPGIAYFI 145
|
|
| MFS_2 |
pfam13347 |
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ... |
61-380 |
2.17e-05 |
|
MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.
Pssm-ID: 433134 [Multi-domain] Cd Length: 427 Bit Score: 46.15 E-value: 2.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 61 LFGPLSDK----IGRKRPLIL-SLLLFIVSSILCATTNNIY------WLVVWRFIQGIAGAGGSVLSRS----IARDKYQ 125
Cdd:pfam13347 52 IVGHIIDRtrtrWGRRRPWLLlSAIILAVSFILLFTPPELGraplfiWLLATYILLRIAYTFFEIPYWSlgpeLTRDYDE 131
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 126 GVTLTQFFALLMTVNGLAP-VLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLF-----------INETLPENKRGS 193
Cdd:pfam13347 132 RTSLTSYRSFFSVGGGLLAaALAFPLVLILGGTGLERKGYRIFALIGAVLMLLGVIItaagtkervsmRSKEDTGQKEAG 211
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 194 SLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGfNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMT 273
Cdd:pfam13347 212 SLLDMLKEVFRNRAFLILLASFLLAALAMGVLNGLLLYYFRYVLG-NGFAASAFPLVFTIGALLGIPLWPPLAKRIGKKN 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 274 LLRGGLIAAIlcaLLTVLCAWIQlpiPALVALFFTIAFCSGIGTVGGAEAMSAV------------GTQESGTASAL--- 338
Cdd:pfam13347 291 TYILGALITI---AGFALALLLG---PNNTLLFLVLYIIIGFGYGSSFFLPWSMladvvdygelrtGKRREGTFFAMwsf 364
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 446057161 339 -----MGMSMFVFG------GIAAPLSGIGGETLLKMSLAITVCYTLALLVAL 380
Cdd:pfam13347 365 isklaTGVGLGVSGlllsafGYNAGDSVQSPQAVTAIRLLYAVLPAVLFLVAL 417
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
58-166 |
2.39e-05 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 46.23 E-value: 2.39e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 58 GQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG--GSVLSRSIA------RDKYQGVTL 129
Cdd:PRK03893 71 GGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGMAGeyGSSATYVIEswpkhlRNKASGFLI 150
|
90 100 110
....*....|....*....|....*....|....*..
gi 446057161 130 TQFfallmtvnGLAPVLSPVLGGYIVSTFDWRTLFWV 166
Cdd:PRK03893 151 SGF--------SIGAVVAAQVYSLVVPVWGWRALFFI 179
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
56-356 |
2.68e-05 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 45.68 E-value: 2.68e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 56 GVGQLLFGP----LSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGaGGSVLSRSIARDKYQGVTLTQ 131
Cdd:cd17390 41 GALQLFSSPlvgsWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFK-HTQSLCKAYLSDLVSEQERSR 119
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 132 FFALLMTVNGLAPVLSPVLGGYIVstfDWRTLFWVMAEISTVLLLGCLLFINETLPenKRGSSLLLtgrsvvqnrrfmRF 211
Cdd:cd17390 120 VLGRFNAASSLGFILGPVVGGHLA---ETDGGFYYVALLCSAIFILNAGLVWFLLS--KLWDLLLV------------RF 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 212 CLIQSFMLaglfaYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRgGLIAAILCALLTVL 291
Cdd:cd17390 183 LMGFSVLL-----FRSNFSLYLEERFDLSPKTIGYLISYSGVLGALSGFLVGRILKLYKNNEYLL-LLHSFILLALSLLG 256
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446057161 292 CAWIQlPIPALVALFFTIAFCSGIGTVGGAEAM-SAVGTQESGTasaLMGMSMFV--FGGIAAP-LSGI 356
Cdd:cd17390 257 LALAP-SIWLLVLCLTPLSISSAVLRTCSTSLLlSRGKSKERGT---LLGVGQSVtsLARILAPlLSGL 321
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
61-355 |
7.64e-05 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 44.56 E-value: 7.64e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 61 LFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAG---AGGSVLSRSIARDKYQGVTLtqffALLM 137
Cdd:cd17391 55 IWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSgyvPNATALIASQTPKEKSGWAL----GTLS 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 138 TVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINET-LPENKRGSSLLLTGRSVVQNRRfmrfcLIQS 216
Cdd:cd17391 131 TGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVKEDfKPVEKKKMVSTKEVWNSVPNPS-----LLIS 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 217 FMLAGLFAYIGSSS-------FVLQ-KEFGFNPMQFS-LVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAilcAL 287
Cdd:cd17391 206 LFVTTFIIQLANQSiepiltlYIRQlMGDASNLAFISgLVFSATGVSSLLSAPRLGKLGDRIGHHRILLGALLAS---AL 282
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446057161 288 LTVLCAWIQLPIpALVALFFTIAFCSGiGTVGGAEAMSAVGTQESGTASAL-MGMSMFVFGGIAAPLSG 355
Cdd:cd17391 283 LYIPQAFVQTPW-QLGILRFLLGLATG-GLLPAINSLLAKITPKEVAGRIFgYNQSFQYLGNVAGPLLG 349
|
|
| PRK12307 |
PRK12307 |
MFS transporter; |
51-213 |
8.06e-05 |
|
MFS transporter;
Pssm-ID: 237051 [Multi-domain] Cd Length: 426 Bit Score: 44.53 E-value: 8.06e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLT 130
Cdd:PRK12307 62 AFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMGMAGEYACASTYAVESWPKHLKS 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 131 QFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVmaEISTVLLlgcLLFINETLPENKRGSSLLLTGRSVVQNRRFMR 210
Cdd:PRK12307 142 KASAFLVSGFGIGNIIAAYFMPSFAEAYGWRAAFFV--GLLPVLL---VIYIRARAPESKEWEEAKLSGKGKHSQSAWSV 216
|
...
gi 446057161 211 FCL 213
Cdd:PRK12307 217 FSL 219
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
29-353 |
8.80e-05 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 44.29 E-value: 8.80e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 29 ALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA 108
Cdd:TIGR00881 17 AMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIF 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 109 GAGGSVLSRSIARDKYQGVTLTQFFALLMTVNGLAPVLSPVLGGYIVSTF-DWRTLFWVMAEISTVLLLGCLLFINET-- 185
Cdd:TIGR00881 97 QGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELySWHWVFIVPGIIAIIVSLICFLLLRDSpq 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 186 ---LP----------------ENKRGSSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQ--- 243
Cdd:TIGR00881 177 scgLPpaeempneepdgdaekKEEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWSPLYLTQEKGFSKEKasw 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 244 FSLVFGLNGI-GLIIASWIFSRLARRinamtllRGGLIAAILCALLTVLCAWIQLPI----PALVALFFTIAFCS-GIGT 317
Cdd:TIGR00881 257 AFTLYELGGLvGTLLAGWLSDKLFNG-------RRGPLAVFFMALIIVSLLVYWLNPaanpLMDLICLFALGFLVyGPQM 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 446057161 318 VGGAEAMSAVGTQESGTASALMGMsMFVFGGIAAPL 353
Cdd:TIGR00881 330 LIGVIASELAPKKAAGTAAGFVGF-FAYLGGILAGL 364
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-346 |
1.13e-04 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 43.80 E-value: 1.13e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSR-----SIARDKYQ 125
Cdd:cd17355 47 GLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATSLWQLYLLWGLLGGGGAGTLAAVAfatvaAWWFERRR 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 126 GVTLTqffaLLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLF-------INETLPENKRGSSLLLT 198
Cdd:cd17355 127 GLALG----ILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLlrrrpadLALRAYDDASPASPGST 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 199 GRSVVQNRRFMRF-------CLIQSFMLAGLFAYIGsssfvlqkEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINA 271
Cdd:cd17355 203 LKEALRSASFWLLalafflcGFAVVGLIVHLVPYLA--------DRGISPAAAAVALALIGLFNIVGRLLSGWLGDRYSP 274
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446057161 272 MTLLrggliAAILCALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFVF 346
Cdd:cd17355 275 RRLL-----AASYALRALGLALLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGLVFAPH 344
|
|
| MFS_HXT |
cd17356 |
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ... |
53-116 |
1.57e-04 |
|
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340914 [Multi-domain] Cd Length: 403 Bit Score: 43.39 E-value: 1.57e-04
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSIL-CATTNNIYWLVVWRFIQGIAGAGGSVLS 116
Cdd:cd17356 56 LGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIqVAAIGKWYQLIVGRIIAGLGVGFASVLV 120
|
|
| MFS_SLC22A6_OAT1_like |
cd17446 |
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ... |
54-111 |
1.92e-04 |
|
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341004 [Multi-domain] Cd Length: 339 Bit Score: 43.17 E-value: 1.92e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 54 GLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG 111
Cdd:cd17446 45 GVLVGAIVFGGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSG 102
|
|
| MFS_MFSD10 |
cd17389 |
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ... |
61-191 |
2.64e-04 |
|
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340947 [Multi-domain] Cd Length: 391 Bit Score: 42.65 E-value: 2.64e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 61 LFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSvLSRSIARDKYQGVTLTQFFALLMTVN 140
Cdd:cd17389 83 ITGAASDVYGRKPVLLLTMIGLAISYALWAVSRSFTIFLLSRIVGGISKGNVS-LSTAIVADVTSPKKRSKGMALIGVAF 161
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446057161 141 GLAPVLSPVLGGYIVS-TFDWRTLFWVMAEI-STVLLLGCLLFI----NETLPENKR 191
Cdd:cd17389 162 SLGFIIGPMIGAYFASfTRSLGEVFFSMPALfALVLALADLLFIffflPETLPSNLR 218
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
9-291 |
2.73e-04 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 42.68 E-value: 2.73e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 9 ALILGLLAGIGPMctdLYLPALPEMSEQLAATTTITQLTLTASLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSIL 88
Cdd:cd06180 4 ALALAVAMGIGRF---AYTPLLPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRLIRGGLLLTVLLLAA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 89 CATTNNIYWLVVWRFIQGIAGAG----GSVLSRSIARDKYQGVTLTQFFAllmtVNGLAPVLSPVL-GGYIVSTFDWRTL 163
Cdd:cd06180 81 MALTSGFAALLALRFLAGAASAFvfvfGSNLVLHHATAAGRGHLIGLLFA----GVGLGIALSGLLvPAGLGGGLSWRAG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 164 FWVMAEISTVLLLGCLLFINETLPENKRGSSLlltGRSVVQNRRFMRfcLIQSFMLAGlFAYIGSSSF--VLQKEFGFNP 241
Cdd:cd06180 157 WLALALLSAVLLLLSFLLLRRGPSAPTEASAA---ESAPGLNRPLWR--LALAYGLFG-FGYIITATFlpLIARETGAGS 230
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|
gi 446057161 242 MQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALLTVL 291
Cdd:cd06180 231 LLAGLLWSLFGLAAVPSCFLWGALSDRWGTRRALAANLLVQAVGVLLPLL 280
|
|
| PRK10504 |
PRK10504 |
putative transporter; Provisional |
63-164 |
2.92e-04 |
|
putative transporter; Provisional
Pssm-ID: 182502 [Multi-domain] Cd Length: 471 Bit Score: 42.80 E-value: 2.92e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 63 GPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGA-----GGSVLSRSIARDKYQGVTltqffaLLM 137
Cdd:PRK10504 66 GWLADRVGVRNIFFTAIVLFTLGSLFCALSGTLNELLLARVLQGVGGAmmvpvGRLTVMKIVPREQYMAAM------TFV 139
|
90 100
....*....|....*....|....*...
gi 446057161 138 TVNG-LAPVLSPVLGGYIVSTFDWRTLF 164
Cdd:PRK10504 140 TLPGqVGPLLGPALGGLLVEYASWHWIF 167
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
51-380 |
3.39e-04 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 42.24 E-value: 3.39e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYW-LVVWRFIQGIAGAGGSVLSRSIAR---DKYQG 126
Cdd:cd17341 43 PVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALAVSSYWgLLVLGFLLGFAGANFASGQPWASFwfpKEKIG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 127 VTLTQFFALLMTVNGLAPVLSPVLGGYIV---STFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSLLLTGRSVV 203
Cdd:cd17341 123 GAAGGIAGAGNMGVAVSQLLAPLIAGAIVfdgGFVGWRNAFFVPGILLAIAAVLVLLFGDDLPTGKASALEFLKVQLAVL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 204 QNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAI 283
Cdd:cd17341 203 KNYRTWILSLLYGVTFGSFVGFSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLFIVMT 282
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 284 LCAlltVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEA----MSAVGTQESGTASALMGMSMFVFGGIAAPLSGIGGE 359
Cdd:cd17341 283 IGA---ALLSLSLPTSGTNLVLFLALFVALGLGAGAGNGSvfrmVPFIFRRELGAVTGLVGAIGGLGGFFLPLLFGSSAL 359
|
330 340
....*....|....*....|.
gi 446057161 360 TLLKMSLAITVCYTLALLVAL 380
Cdd:cd17341 360 MTGSGVGAFSLFGVLAVACTL 380
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
60-355 |
6.23e-04 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 41.38 E-value: 6.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVvwrFIQGIAGAGGSVLSRSIARdkyqgVTLTQFF------ 133
Cdd:cd17352 56 PLSSALVNRFGCRPVAIAGGLLAALGLLLSSFATSLWQLY---LTYGVLGGLGLGLIYSPAI-----VIVGQYFekkrgl 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 134 --ALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFInetlpenkrgssllltgrsVVQNRRFMRF 211
Cdd:cd17352 128 atGIAVAGSGVGTFVFPPLLRYLLDNYGWRGALLILGGLCLNLCVCGLLLR-------------------LLKDPTFVLL 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 212 CLIQSFMLAGLFAYIGSSSFVLqKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGglIAAILCALLTVL 291
Cdd:cd17352 189 ALGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLY--IFTLLILGLSLL 265
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446057161 292 CAWIQLPIPALVALFFTIAFCSG-IGTVGGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSG 355
Cdd:cd17352 266 AFPLATTYVGLIVFSVLFGFCSGsYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAG 330
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
53-181 |
7.26e-04 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 41.45 E-value: 7.26e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQF 132
Cdd:cd06173 255 VGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRV 334
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446057161 133 FALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLF 181
Cdd:cd06173 335 FSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_SVOP_like |
cd17372 |
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator ... |
53-186 |
9.30e-04 |
|
Synaptic vesicle 2-related protein (SVOP) and related proteins of the Major Facilitator Superfamily; This subfamily is composed of synaptic vesicle 2 (SV2)-related protein (SVOP), SVOP-like protein (SVOPL), and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. Like SV2, SVOP is expressed in all brain regions, with highest levels in cerebellum, hindbrain and pineal gland. Studies with knockout mice suggets that SVOP may perform a subtle function that is not necessary for survival under normal conditions, since mice lacking SVOP are viable, fertile, and phenotypically normal. SVOP and SVOPL share structural similarity to the solute carrier family 22 (SLC22), a large family of organic cation and anion transporters. The SVOP-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340930 [Multi-domain] Cd Length: 367 Bit Score: 40.98 E-value: 9.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIAR---DKYQG--V 127
Cdd:cd17372 45 AGMMIGSYLWGIVSDKYGRRKGLIISALWTFYAGFLSAFAPNYMWLIILRCLVGLGLGGGPQLASWYLEflpAKSRGtwM 124
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 446057161 128 TLTQFFALLMTvnglapVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETL 186
Cdd:cd17372 125 VLFSVFWTVGT------IFEASLAWLVMPRLGWRWLLAFSSVPSSLLLVFYRWTPKTTL 177
|
|
| MFS_3 |
pfam05977 |
Transmembrane secretion effector; This is a family of transport proteins. Members of this ... |
60-305 |
1.18e-03 |
|
Transmembrane secretion effector; This is a family of transport proteins. Members of this family include a protein responsible for the secretion of the ferric chelator, enterobactin, and a protein involved in antibiotic resistance.
Pssm-ID: 399164 [Multi-domain] Cd Length: 523 Bit Score: 40.89 E-value: 1.18e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGI--AGAGGSVLSRSI---------ARDKYQGVT 128
Cdd:pfam05977 63 IPAGALADNFDRRKIMLAGQLLLALVSTLLTLLAGLGLLSPWLLLGLTflGGIGTALMDPAWqasvpelvpRRDLPAAVA 142
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 129 LTQffallMTVNgLAPVLSPVLGGYIVSTFDWRTLFWVMAeISTVLLLGCLLFINETLPENKRGSSLLLTGrsVVQNRRF 208
Cdd:pfam05977 143 LNS-----VGYN-IARSVGPALGGVLLAAFGPAFTFALNA-LSYFAVIAALWRWKRAAPASPLPRERIFGA--VRAGLRF 213
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 209 MRFCL-IQSFMLAGLFAYIGSSS------FVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIA 281
Cdd:pfam05977 214 TAMSReLRSVLVRAFAFGLSASAvwallpLVARDLLDGDAIFYGILLGAVGVGAILGALSLPRLRERLGSDRLVLLASVV 293
|
250 260
....*....|....*....|....
gi 446057161 282 AILCALLTVLCAWIQLPIPALVAL 305
Cdd:pfam05977 294 TALVLLSLALAPNLWLAIPVLLLG 317
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
206-356 |
1.46e-03 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 40.34 E-value: 1.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 206 RRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLrggLIAAILC 285
Cdd:COG2814 9 WLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVL---LLGLLLF 85
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446057161 286 ALLTVLCAWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSGI 356
Cdd:COG2814 86 ALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL 156
|
|
| MFS_MFSD6 |
cd17335 |
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily ... |
57-382 |
1.48e-03 |
|
Major facilitator superfamily domain-containing protein 6; Human Major facilitator superfamily domain-containing protein 6 (MFSD6) is also called macrophage MHC class I receptor 2 homolog (MMR2). It has been postulated as a possible receptor for human leukocyte antigen (HLA)-B62. MFSD6 is conserved through evolution and appeared before bilateral animals. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340893 [Multi-domain] Cd Length: 375 Bit Score: 40.26 E-value: 1.48e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 57 VGQLLFGPLSDKIG-RKRPLILSLLLFIVSSILCATTNNIYW-LVVWRFIQGIAGAGGSVLSRSIA-------RDKYQGV 127
Cdd:cd17335 47 LSAPLWGALADRFGkRKALLLLSLLAAVLFFLSLFFVAQIFWlLLLLVILGAFFSAPVVPLVDSITlqylgeeRERYGKQ 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 128 TLTQFFALlmtvnGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINEtlPENKRGSSLLLTGRSVVQNRR 207
Cdd:cd17335 127 RLWGSIGF-----GIAALLVGILIDRSSTYKNYTIAFYVFAVLMLLALLLALKFPFR--PKHPEPNENTGGLLALLRNPR 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 208 FMRFcLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCAL 287
Cdd:cd17335 200 VLAF-LLVAFLMGFGHGLIYSFLFWHLQDLGGSKTLIGLLWTVGVVSEIPFFFFSSRLIQRFGHVGLLYLGLLAYVVRWL 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 288 LTVLC--AWIQLPIPALVALFFTIAFCSGIGTVGGAEAMSAVGTQESGTASALMGMSMFVFGGIAAPLSGIGGETLLKMS 365
Cdd:cd17335 279 LYSFLenPWLVLPIELLHGLTFALVWAAAVSYASAAAPPGLRATAQGLLQGLYFGLGGGLGSLIGGYLYEAFGARTTFRF 358
|
330
....*....|....*..
gi 446057161 366 LAITVCYTLALLVALTR 382
Cdd:cd17335 359 FAIAALAGLLAFFLIQR 375
|
|
| MFS_SLC22A7_OAT2 |
cd17447 |
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major ... |
53-116 |
1.57e-03 |
|
Solute carrier family 22 member 7 (also called Organic anion transporter 2) of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 7 (SLC22A7), also called organic anion transporter 2 (OAT2) mediates sodium-independent transport of a variety of organic anions including prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha-ketoglutarate. It also plays a role in renal uric acid uptake from blood as a first step of tubular secretion. OAT2 belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS)of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341005 [Multi-domain] Cd Length: 341 Bit Score: 40.10 E-value: 1.57e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLS 116
Cdd:cd17447 46 AGVTMGAVAFGYLSDRFGRKRMLLVAYVLSLVFGLASAFSVSYVMFAITRTLTGFALTGFSIIS 109
|
|
| MFS_Amf1_MDR_like |
cd17476 |
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ... |
60-288 |
1.70e-03 |
|
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341029 [Multi-domain] Cd Length: 362 Bit Score: 39.94 E-value: 1.70e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQF-FALLMT 138
Cdd:cd17476 51 LIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLPNAMALLGRTYPPGPRKNIvFSLFGA 130
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 139 VNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFInetlpenkrgssllltgrsvvqNRRFMRFCLIQSFM 218
Cdd:cd17476 131 TAPLGFALGGVFGGLFAQLAWWPWIFWFLAILAAIVAVAAIFWT----------------------SPSFIAVLLAVFLG 188
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 219 LAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMTLLRGGLIAAILCALL 288
Cdd:cd17476 189 WASFGIWVFYATQYFQNVRGYSPLLTSARFIPMAIGGVLAAITVGFLIARLPPSYIMAISMVAFLVGPIL 258
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
56-168 |
1.73e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 40.33 E-value: 1.73e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 56 GVGQLLFGP----LSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG--GSVLS--RSIARDKYQGv 127
Cdd:cd17391 250 GVSSLLSAPrlgkLGDRIGHHRILLGALLASALLYIPQAFVQTPWQLGILRFLLGLATGGllPAINSllAKITPKEVAG- 328
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 446057161 128 tltQFFALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMA 168
Cdd:cd17391 329 ---RIFGYNQSFQYLGNVAGPLLGSAIAAHFGYRAVFVVTA 366
|
|
| MFS_GLUT8_Class3 |
cd17433 |
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ... |
53-185 |
1.79e-03 |
|
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340991 [Multi-domain] Cd Length: 416 Bit Score: 40.25 E-value: 1.79e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA-GAGGSVLSRSIARDKYQGVTLTQ 131
Cdd:cd17433 52 LGAAAGGVLGGWIVDRAGRKLSLMLCSVPFIAGFTVITAAQNVWMLYVGRLLTGLAsGVTSLVVPVYISEIAHPRVRGTL 131
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 446057161 132 FFAL-LMTVNGlapvlspVLGGYIVS-TFDWRTLFwVMAEISTVLLLGCLLFINET 185
Cdd:cd17433 132 GSCVqLMVVIG-------IMGAYLAGlVLDWRWLA-VLGSIPPTLMLLLMCFMPET 179
|
|
| MFS_MFSD5_like |
cd17487 |
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily ... |
63-315 |
1.99e-03 |
|
Major facilitator superfamily domain containing 5 protein; Human major facilitator superfamily domain containing 5 protein (MFSD5) is also called molybdate-anion transporter, or molybdate transporter 2 homolog (MOT2). It acts as an atypical solute carrier (SLC) that mediates high-affinity intracellular uptake of the rare oligo-element molybdenum. It may also play a role in maintaining the glucose homeostasis and pancreatic beta-cell proliferation, as well as in altered energy homeostasis. MFSD5 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341040 Cd Length: 385 Bit Score: 39.89 E-value: 1.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 63 GPLSDKIGRKRpliLSLLLFIVSSILCATT--NNIYWLVVWRFIQGIAgagGSVL-------------SRSIARDKyqgv 127
Cdd:cd17487 59 GSLADKFGRKR---ACLLFCVLYSLSCLTKhsPNFGVLLLGRVLGGIS---TSLLfsafeswmvhehnKRGFFPKE---- 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 128 TLTQFFALLMTVNGLAPVLSpvlgGYIVSTFDWRTLFWVM-AEISTVLLLGCLLFINETLPENK-------RGSSLLLTG 199
Cdd:cd17487 129 WLSTTFSKATLGNGLVAILA----GLVANFAEALGFGPVApFDAAIPFLVLAGVLIMRTWTENYgdpsspsRLGCQEEAL 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 200 RSVVQNRRFMRFCLIQSFMLAGLfaYIgsssFVLQ-----KEFGFNPMQFSLVFGLNGIGLIIASWIFSRL-ARRINAMT 273
Cdd:cd17487 205 RAILSDKKVLLLGAIQSLFESAM--YI----FVFLwtpalDPAQSGGVPLGIIFACFMVAMMIGSSLFRLLlSKRVSPEH 278
|
250 260 270 280
....*....|....*....|....*....|....*....|..
gi 446057161 274 LLRGGLIAAILCALLTVLCAWIQLPIPALVAlFFTIAFCSGI 315
Cdd:cd17487 279 LLVIVLLVASVSLFLPVVSTITSSPKILLLA-FLVFEACVGL 319
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
60-177 |
2.99e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.45 E-value: 2.99e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA-GAGGSVLSRSIARDKYQGVTLTQfFALLMT 138
Cdd:cd17370 252 YPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLWLLLLGFILWGLYmGAQESIERAAVADLVPAELRGTA-YGLFNT 330
|
90 100 110
....*....|....*....|....*....|....*....
gi 446057161 139 VNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLG 177
Cdd:cd17370 331 VVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_SLC45_SUC |
cd17313 |
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ... |
60-180 |
3.35e-03 |
|
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340871 [Multi-domain] Cd Length: 421 Bit Score: 39.15 E-value: 3.35e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 60 LLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIARDKYQGVTLTQ--FFALLM 137
Cdd:cd17313 299 LPIGKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWATININPYPLVSDYHSESGRGQgtDTGLLN 378
|
90 100 110 120
....*....|....*....|....*....|....*....|...
gi 446057161 138 TVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLL 180
Cdd:cd17313 379 LAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
|
|
| MFS_GLUT10_12_Class3_like |
cd17362 |
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ... |
51-108 |
3.88e-03 |
|
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340920 [Multi-domain] Cd Length: 389 Bit Score: 38.87 E-value: 3.88e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*...
gi 446057161 51 SLIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIA 108
Cdd:cd17362 48 SLLGALLGSLVAGALIDRLGRRKELILAALLYLVGSLVTGLAPSYPVLLVGRLIYGVG 105
|
|
| TRI12 |
pfam06609 |
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ... |
53-255 |
4.13e-03 |
|
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.
Pssm-ID: 115279 [Multi-domain] Cd Length: 598 Bit Score: 39.27 E-value: 4.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 53 IGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAG--AGGSVL-SRSIARDKyqgvtl 129
Cdd:pfam06609 89 MGQAVSILMMGRLTDRFGRRPFVIATHIIGLVGAIVGCTANKFNTLLAAMTLLGVAAgpAGASPLfIGELMSNK------ 162
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 130 TQFFALLMTVnglAPV-----LSPVLGGYIVSTFDWRTLFWVMAEISTVLLLgcLLFINETLPENKRgssllLTGRSVVQ 204
Cdd:pfam06609 163 TKFLGLLIVS---APTiamngAGPYFGQRLAIQGNWRWIFYIYIIMSAIAVL--LIIIWYHPPSFAQ-----LHGKKARK 232
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 446057161 205 NRRFMRFCLIQSFMLAglfayIGSSSFVLQKEFG---FNPMQFSLVFGLNGIGL 255
Cdd:pfam06609 233 RDELAKLDWIGIFLVI-----AGTSLFLLGVSWGgkpNNPWNSAKIIGLISSGA 281
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
57-313 |
4.36e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 38.82 E-value: 4.36e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 57 VGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNI----YW----LVVWRFIQGIA-----GAGGSVLSRSIARDK 123
Cdd:cd17367 55 IGGWLFGRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYatigIWapiiLLLARLLQGLSvggeyGTSATYLSEVAPPGR 134
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 124 ------YQGVTLTqffALLMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVlllgcLLFINETLPEN---KRGSS 194
Cdd:cd17367 135 rgfyssFQYVTLI---GGQLLALGVLLVLQHTLGEDQMAAWGWRIPFLLGGVLAVV-----VLWLRRGLEETesfEAIAE 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 195 LLLTGRSVVQN-----RRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRI 269
Cdd:cd17367 207 SNEASAGTLRElrrhpRELLLVVGLTAGGTLAFYTWTTYLQKFLVNTAGFSKGDATWITTAALLVFMLLQPLGGRLSDRI 286
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 446057161 270 NAMTLLrggLIAAILCALLTVLC--------AWIQLPIPALVALFFTIAFCS 313
Cdd:cd17367 287 GRRPLL---LFFGIGGTLATVPLlsaldhtdSPYTAFALVLVGLVFLSGYTS 335
|
|
| MFS_MFSD14 |
cd17387 |
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ... |
61-284 |
5.22e-03 |
|
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340945 [Multi-domain] Cd Length: 410 Bit Score: 38.55 E-value: 5.22e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 61 LFGPLSDKIGRKRPLILSLLlFIVSSILCATTNNiYWLVVWRFIQGIAGAGGSVLSRSIA-------RDKYQGVTLTQFF 133
Cdd:cd17387 55 LIGALSDVWGRKSFLLLTVF-FTCAPIPLMRISP-WWYFAMISVSGIFSVTFSVIFAYVAditteeeRSTAYGLVSATFA 132
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 134 ALLmtvnglapVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFINETLPENKRGSSL-----------LLTGRSV 202
Cdd:cd17387 133 ASL--------VTSPALGAYLSESYGDNLVVLVATIVALLDICFILLAVPESLPEKMRPASWgapisweqadpFASLRKV 204
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 203 VQNRRFMRFCLIqSFMLAGLFAYIGSSSFV-LQKEFGFNPMQFSLVFGLNGIGLIIASWIF-SRLARRINAMTLLRGGLI 280
Cdd:cd17387 205 GKDKTVLLICIT-VFLSYLPEAGQYSSFFVyLKQVMGFEYEEVAAFIAVVGILSITAQTLLlSILMRSIGAKNTILLGLG 283
|
....
gi 446057161 281 AAIL 284
Cdd:cd17387 284 FQML 287
|
|
| MFS_SLC22A15 |
cd17377 |
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ... |
54-186 |
5.74e-03 |
|
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340935 [Multi-domain] Cd Length: 353 Bit Score: 38.61 E-value: 5.74e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 54 GLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGaGGSVLSRSIARDKYQGvtlTQFF 133
Cdd:cd17377 51 GVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMN-GGMSLVAFVLLNECVG---KSYW 126
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 446057161 134 ALLMTVNGL----APVLSPVLGGYIVStfdWRTLFWVMAEISTVLLLGCLLFINETL 186
Cdd:cd17377 127 ALAGSLGGLffavGIAQYALLGYFIRS---WRTLAVVVNLQGTLVFLLSLFIPGRTL 180
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
56-182 |
6.77e-03 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 38.32 E-value: 6.77e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 56 GVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQ-GIAGAGGSVLSRSIARDKYQGVTLTQFFA 134
Cdd:COG2223 255 ALGRPLGGWLSDRIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFLLlGLALGGGNGAVFALVPDIFPTKNAGAVYG 334
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 446057161 135 LLMTVNGLAPVLSPVLGGYIVSTF-DWRTLFWVMAEISTVLLLGCLLFI 182
Cdd:COG2223 335 LVGAAGGLGGFLGPLLFGALLDATgSYTAAFLVFAVLALVALVLTLLLY 383
|
|
| PRK03545 |
PRK03545 |
putative arabinose transporter; Provisional |
65-316 |
9.53e-03 |
|
putative arabinose transporter; Provisional
Pssm-ID: 179591 [Multi-domain] Cd Length: 390 Bit Score: 37.95 E-value: 9.53e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 65 LSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAGGSVLSRSIA-RDKYQGVTlTQFFALLMTVNGLA 143
Cdd:PRK03545 67 LTSNVERRKLLIGLFVLFIASHVLSALAWNFTVLLISRIGIAFAHAIFWSITASLAiRVAPAGKK-AQALSLLATGTALA 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 144 PVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLgCLLFINETLPENKRGS--SL-------------LLTgrSVVQNRRF 208
Cdd:PRK03545 146 MVLGLPLGRVIGQYLGWRTTFLAIGGGALITLL-LLIKLLPLLPSEHSGSlkSLpllfrrpalvslyLLT--VVVVTAHF 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 209 MRFCLIQSFMLAGLFAYIGSSSFVLqkefgfnpmqfsLVFGLNGIgliIASWIFSRLARRINAMTLLrgGLIAAILCALL 288
Cdd:PRK03545 223 TAYSYIEPFVQQVAGLSENFATLLL------------LLFGGAGI---IGSVLFSRLGNRHPSGFLL--IAIALLLVCLL 285
|
250 260
....*....|....*....|....*...
gi 446057161 289 TVlcawiqLPIPALVALFFTIAFCSGIG 316
Cdd:PRK03545 286 LL------LPAANSEWHLSVLSIFWGIA 307
|
|
| MFS_PLT |
cd17437 |
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ... |
57-107 |
9.83e-03 |
|
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340995 [Multi-domain] Cd Length: 387 Bit Score: 37.77 E-value: 9.83e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|.
gi 446057161 57 VGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGI 107
Cdd:cd17437 47 VGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGVAPNYPVLMVGRFVAGI 97
|
|
| BtlA |
COG2270 |
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction ... |
61-325 |
9.89e-03 |
|
MFS-type transporter involved in bile tolerance, Atg22 family [General function prediction only];
Pssm-ID: 441871 [Multi-domain] Cd Length: 424 Bit Score: 37.82 E-value: 9.89e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 61 LFGPLSDKIGRKRP-LILSLLLFIVSSILC--ATTNNIYWLVVWRFIQGIAGAGGSVLSRS----IARDKYQGVTLTQFF 133
Cdd:COG2270 71 VLGAIADRSGRKKPfLAFFTLLGVLATAALffVAPGGLWLGLLLFVLANIGFEGSLVFYNAflpdIATPEEIGRVSGLGW 150
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 134 AL------LMTVNGLAPVLSPVLGGYIVSTFDWRTLFWVMAeistVLLLGCLLFINETLPENKRGSS------------- 194
Cdd:COG2270 151 ALgylggvLLLLINLALFLKPEAFGLPDAGEAVRISFLLTA----LWWLLFALPLFLFLPERPRPGPapprgavragfre 226
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 195 LLLTGRSVVQNRRFMRFcLIQSFML-AGLFAYIGSSSFVLQKEFGFNPMQFSLVFGLNGIGLIIASWIFSRLARRINAMT 273
Cdd:COG2270 227 LRRTLRELRRYRDLLRF-LLAYFFYrDGVQTVIAFAGIYAAGVLGFSTTELIVFGLLVQIVAALGALLFGRLDDRIGPKR 305
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|..
gi 446057161 274 LLRGGLIaailcaLLTVLCAWIQLPIPALValFFTIAFCSGIGtVGGAEAMS 325
Cdd:COG2270 306 VILVSLV------IWIVVCLAAYFLTTALA--FWILGLLIGLV-MGGIQALS 348
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
52-314 |
9.94e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 37.59 E-value: 9.94e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 52 LIGLGVGQLLFGPLSDKIGRKRPLILSLLLFIVSSILCATTNNIYWLVVWRFIQGIAGAG---GSVLSRSIA-----RDK 123
Cdd:cd17353 48 IVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLFLGYGVLGGIGAGigyITPVSTAVKwfpdkRGL 127
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 124 YQGVTLTQFfallmtvnGLAPVLSPVLGGYIVSTFDWRTLFWVMAEISTVLLLGCLLFI-----------NETLPENKRG 192
Cdd:cd17353 128 ATGIVIAGF--------GLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdppkgwvppgVDPLANNAEN 199
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446057161 193 SSLLLTGRSVVQNRRFMRFCLIQSFMLAGLFAYIGSSSFVLQKEFGFNPMQFSLVFGL----NGIGLIIASWIFSRLARR 268
Cdd:cd17353 200 SPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSIlsifNGGGRPFWGWLSDKIGRK 279
|
250 260 270 280
....*....|....*....|....*....|....*....|....*.
gi 446057161 269 INAMTLLrggLIAAILCALLTvlcaWIQLPIPALVALFFTIAFCSG 314
Cdd:cd17353 280 NTLSIAF---LIQGVAMFLLP----FIGSVAVLFVLGVALIGFCYG 318
|
|
|