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Conserved domains on  [gi|446050741|ref|WP_000128596|]
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MULTISPECIES: ATPase, T2SS/T4P/T4SS family [Gammaproteobacteria]

Protein Classification

P-loop NTPase family protein( domain architecture ID 1562424)

P-loop NTPase (nucleoside triphosphate hydrolase) family protein contains two conserved sequence signatures, the Walker A motif (the P-loop proper) and Walker B motif which bind, respectively, the beta and gamma phosphate moieties of the bound nucleotide (typically ATP or GTP), and a Mg(2+) cation

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
P-loop_NTPase super family cl38936
P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain ...
15-318 4.01e-79

P-loop containing Nucleoside Triphosphate Hydrolases; Members of the P-loop NTPase domain superfamily are characterized by a conserved nucleotide phosphate-binding motif, also referred to as the Walker A motif (GxxxxGK[S/T], where x is any residue), and the Walker B motif (hhhh[D/E], where h is a hydrophobic residue). The Walker A and B motifs bind the beta-gamma phosphate moiety of the bound nucleotide (typically ATP or GTP) and the Mg2+ cation, respectively. The P-loop NTPases are involved in diverse cellular functions, and they can be divided into two major structural classes: the KG (kinase-GTPase) class which includes Ras-like GTPases and its circularly permutated YlqF-like; and the ASCE (additional strand catalytic E) class which includes ATPase Binding Cassette (ABC), DExD/H-like helicases, 4Fe-4S iron sulfur cluster binding proteins of NifH family, RecA-like F1-ATPases, and ATPases Associated with a wide variety of Activities (AAA). Also included are a diverse set of nucleotide/nucleoside kinase families.


The actual alignment was detected with superfamily member TIGR02788:

Pssm-ID: 476819  Cd Length: 308  Bit Score: 243.80  E-value: 4.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   15 YLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVSSNKLTMQAINDVI---LPGGIRGVICLPPAVI 91
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILsatLPGGERVQIVIPPACE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   92 DGTTAVAFRKDLAADKNLEQLTSEGIFSDCRkitGSKQSLTDDDFFLKELHSSEKWPAFLQTAVEKKRTIVICGETGSGK 171
Cdd:TIGR02788  81 NDTVSITIRKPSLVDFSLDDYEEKGFFDTVR---AQSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGSGK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  172 TVLTRALLKSLHKDERVIILEDVHEVTVDHVvEAVYMMYG-DAGKIGRVSATDALRACMRLTPGRIIMTELRDDAAWDYL 250
Cdd:TIGR02788 158 TTFLKSLVDEIPKDERIITIEDTREIFLPHP-NYVHLFYSkGGQGLAKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFI 236
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446050741  251 KALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDMSDIMRMLYSTIDVVVHMEK----RKIKEIYF 318
Cdd:TIGR02788 237 RAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQINRrgggRKITEVYF 308
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
15-318 4.01e-79

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 243.80  E-value: 4.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   15 YLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVSSNKLTMQAINDVI---LPGGIRGVICLPPAVI 91
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILsatLPGGERVQIVIPPACE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   92 DGTTAVAFRKDLAADKNLEQLTSEGIFSDCRkitGSKQSLTDDDFFLKELHSSEKWPAFLQTAVEKKRTIVICGETGSGK 171
Cdd:TIGR02788  81 NDTVSITIRKPSLVDFSLDDYEEKGFFDTVR---AQSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGSGK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  172 TVLTRALLKSLHKDERVIILEDVHEVTVDHVvEAVYMMYG-DAGKIGRVSATDALRACMRLTPGRIIMTELRDDAAWDYL 250
Cdd:TIGR02788 158 TTFLKSLVDEIPKDERIITIEDTREIFLPHP-NYVHLFYSkGGQGLAKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFI 236
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446050741  251 KALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDMSDIMRMLYSTIDVVVHMEK----RKIKEIYF 318
Cdd:TIGR02788 237 RAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQINRrgggRKITEVYF 308
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
147-320 2.07e-66

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 206.62  E-value: 2.07e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 147 WPAFLQTAVEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDH--VVEAVYMMYGDAGkiGRVSATDA 224
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLPHpnVVHLLTRPGGGEK--GEVTMADL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 225 LRACMRLTPGRIIMTELRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKATpiGRMLDMSDIMRMLYSTIDV 304
Cdd:cd01130   79 LKAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEA--GVNLDEEALRRLIASAIDV 156
                        170       180
                 ....*....|....*....|.
gi 446050741 305 VVHMEK-----RKIKEIYFDP 320
Cdd:cd01130  157 IVHVKRlgdgvRRVTEIYEVP 177
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
4-316 4.56e-56

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 186.53  E-value: 4.56e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   4 AAFYQLGPLREYLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVS--------SNKLTmqainDVI 75
Cdd:COG4962   51 DELFGLGPLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAArvgrrldeSSPIV-----DAR 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  76 LPGGIRGVICLPPAVIDGTTaVAFRKdlaadknleqltsegiFSdcrkitgsKQSLTDDDffLKELHS-SEKWPAFLQTA 154
Cdd:COG4962  126 LPDGSRVNAVIPPVARDGPS-LSIRK----------------FR--------KRPLTLED--LVALGSlTPEMAEFLRAA 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 155 VEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHvvEAVYMMY---GDAGKIGRVSATDALRACMRL 231
Cdd:COG4962  179 VRARLNILVSGGTGSGKTTLLNALSGFIPPDERIVTIEDAAELQLQH--PHVVRLEtrpPNVEGAGEVTLRDLVRNALRM 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 232 TPGRIIMTELRDDAAWDYLKALNTGHPGGvMST-HANSARDAFNRIGLLIKATpiGRMLDMSDIMRMLYSTIDVVVHME- 309
Cdd:COG4962  257 RPDRIIVGEVRGAEALDMLQAMNTGHDGS-MSTlHANSARDALARLETLALMA--GENLPREAVRRQIASAIDLVVHLEr 333
                        330
                 ....*....|.
gi 446050741 310 ----KRKIKEI 316
Cdd:COG4962  334 lrdgRRRVTEI 344
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
9-321 4.98e-48

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 164.69  E-value: 4.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   9 LGPLREYLEDPTVFEIRIN----CF--QEVICDTFS---GRRVVQNAAITADFIRNlaKSLVSSNKLTMQAindviLPGG 79
Cdd:PRK13851  11 LKPVLEWLDDPRTEEVAINrpgeAFvrQAGVFTKFPlplSYDDLEDIAILAGALRK--QDVGPRNPLCATE-----LPGG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  80 IRGVICLPPAVIDGTTAVAFRKDLAADKNLEQLTSEGIFSDCRKITGSKQSLTDDDFFLKELHSSEKWPAFLQTAVEKKR 159
Cdd:PRK13851  84 ERLQICLPPTVPSGTVSLTIRRPSSRVSELKEVSSRYDASRWNQWQERRKRRDQLDEAILRHYDNGDLEAFLHACVVGRL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 160 TIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHVvEAVYMMYG-DAGKIGRVSATDALRACMRLTPGRIIM 238
Cdd:PRK13851 164 TMLLCGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIPHE-NHVRLLYSkNGAGLGAVTAEHLLQASLRMRPDRILL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 239 TELRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDMSDIMRMLYSTIDVVV----HMEKRKIK 314
Cdd:PRK13851 243 GEMRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAIDVIVpfraYGDVYEVG 322

                 ....*..
gi 446050741 315 EIYFDPE 321
Cdd:PRK13851 323 EIWLAAD 329
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
149-306 1.66e-20

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 89.27  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  149 AFLQTAvekKRTIVICGETGSGKTVLTRALLKSLHK-DERVIILEDVHEVTVDHV----VEAVymmygdagkiGRVSATD 223
Cdd:pfam00437 124 EFLRQP---RGNILVTGPTGSGKTTTLYAALGELNTrDENIVTVEDPVEIQLEGInqvqLNAR----------AGVTFAD 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  224 ALRACMRLTPGRIIMTELRD-DAAWDYLKALNTGHPggVMST-HANSARDAfnrigllikatpIGRMLDMSDIMRMLYST 301
Cdd:pfam00437 191 LLRAILRQDPDRIMVGEIRDlETAEIALQAANTGHL--VLSTlHTNSAAGA------------LTRLQDMGVPPFELASS 256

                  ....*
gi 446050741  302 IDVVV 306
Cdd:pfam00437 257 LLLVI 261
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
157-237 2.90e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   157 KKRTIVICGETGSGKTVLTRALLKSLHKDE-RVIILEDVHEVTVDHVVEAVYMMYGDAGKIGRVSATDALRACMRLTPGR 235
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGgGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                   ..
gi 446050741   236 II 237
Cdd:smart00382  81 VL 82
 
Name Accession Description Interval E-value
VirB11 TIGR02788
P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of ...
15-318 4.01e-79

P-type DNA transfer ATPase VirB11; The VirB11 protein is found in the vir locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for DNA transfer. VirB11 is believed to be an ATPase. VirB11 is a homolog of the P-like conjugation system TrbB protein and the Flp pilus sytem protein TadA.


Pssm-ID: 274301  Cd Length: 308  Bit Score: 243.80  E-value: 4.01e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   15 YLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVSSNKLTMQAINDVI---LPGGIRGVICLPPAVI 91
Cdd:TIGR02788   1 FLDDEDVTEICINRPGEVWVEGPGGWQRFDVPDLTFSHLMRLARAIASFSKQSISEENPILsatLPGGERVQIVIPPACE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   92 DGTTAVAFRKDLAADKNLEQLTSEGIFSDCRkitGSKQSLTDDDFFLKELHSSEKWPAFLQTAVEKKRTIVICGETGSGK 171
Cdd:TIGR02788  81 NDTVSITIRKPSLVDFSLDDYEEKGFFDTVR---AQSGTLSDNDEQLLELLDAGDIKEFLRLAIASRKNIIISGGTGSGK 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  172 TVLTRALLKSLHKDERVIILEDVHEVTVDHVvEAVYMMYG-DAGKIGRVSATDALRACMRLTPGRIIMTELRDDAAWDYL 250
Cdd:TIGR02788 158 TTFLKSLVDEIPKDERIITIEDTREIFLPHP-NYVHLFYSkGGQGLAKVTPKDLLQSCLRMRPDRIILGELRGDEAFDFI 236
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446050741  251 KALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDMSDIMRMLYSTIDVVVHMEK----RKIKEIYF 318
Cdd:TIGR02788 237 RAVNTGHPGSITTLHAGSPEEAFEQLALMVKSSQAGLGLDFAYIVKLVREVIDIVVQINRrgggRKITEVYF 308
VirB11-like_ATPase cd01130
Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, ...
147-320 2.07e-66

Type IV secretory pathway component VirB11-like; Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir (virulence) proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the bacterial Ti (tumor-inducing)-plasmid into plant cells. The pilus is a fibrous cell surface organelle, which mediates adhesion between bacteria during conjugative transfer or between bacteria and host eukaryotic cells during infection. VirB11-related ATPases include Sulfolobus acidocaldarius FlaI, which plays key roles in archaellum (archaeal flagellum) assembly and motility functions, and the pilus assembly proteins CpaF/TadA and TrbB. This alignment contains the C-terminal domain, which is the ATPase.


Pssm-ID: 410874 [Multi-domain]  Cd Length: 177  Bit Score: 206.62  E-value: 2.07e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 147 WPAFLQTAVEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDH--VVEAVYMMYGDAGkiGRVSATDA 224
Cdd:cd01130    1 MAAFLRLAVRARKNILISGGTGSGKTTLLNALLSFIPPDERIVTIEDTRELQLPHpnVVHLLTRPGGGEK--GEVTMADL 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 225 LRACMRLTPGRIIMTELRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKATpiGRMLDMSDIMRMLYSTIDV 304
Cdd:cd01130   79 LKAALRMRPDRIIVGEVRGGEAYDMLQAMNTGHPGSITTIHANSAEDAIDRLATLVLEA--GVNLDEEALRRLIASAIDV 156
                        170       180
                 ....*....|....*....|.
gi 446050741 305 VVHMEK-----RKIKEIYFDP 320
Cdd:cd01130  157 IVHVKRlgdgvRRVTEIYEVP 177
CpaF COG4962
Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and ...
4-316 4.56e-56

Pilus assembly protein, ATPase of CpaF family [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 443988 [Multi-domain]  Cd Length: 386  Bit Score: 186.53  E-value: 4.56e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   4 AAFYQLGPLREYLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVS--------SNKLTmqainDVI 75
Cdd:COG4962   51 DELFGLGPLEPLLDDPDVTDIMVNGPDEVFVERGGRLERTDVRFDSEEELRRLIERIAArvgrrldeSSPIV-----DAR 125
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  76 LPGGIRGVICLPPAVIDGTTaVAFRKdlaadknleqltsegiFSdcrkitgsKQSLTDDDffLKELHS-SEKWPAFLQTA 154
Cdd:COG4962  126 LPDGSRVNAVIPPVARDGPS-LSIRK----------------FR--------KRPLTLED--LVALGSlTPEMAEFLRAA 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 155 VEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHvvEAVYMMY---GDAGKIGRVSATDALRACMRL 231
Cdd:COG4962  179 VRARLNILVSGGTGSGKTTLLNALSGFIPPDERIVTIEDAAELQLQH--PHVVRLEtrpPNVEGAGEVTLRDLVRNALRM 256
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 232 TPGRIIMTELRDDAAWDYLKALNTGHPGGvMST-HANSARDAFNRIGLLIKATpiGRMLDMSDIMRMLYSTIDVVVHME- 309
Cdd:COG4962  257 RPDRIIVGEVRGAEALDMLQAMNTGHDGS-MSTlHANSARDALARLETLALMA--GENLPREAVRRQIASAIDLVVHLEr 333
                        330
                 ....*....|.
gi 446050741 310 ----KRKIKEI 316
Cdd:COG4962  334 lrdgRRRVTEI 344
PRK13851 PRK13851
type IV secretion system protein VirB11; Provisional
9-321 4.98e-48

type IV secretion system protein VirB11; Provisional


Pssm-ID: 172375  Cd Length: 344  Bit Score: 164.69  E-value: 4.98e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   9 LGPLREYLEDPTVFEIRIN----CF--QEVICDTFS---GRRVVQNAAITADFIRNlaKSLVSSNKLTMQAindviLPGG 79
Cdd:PRK13851  11 LKPVLEWLDDPRTEEVAINrpgeAFvrQAGVFTKFPlplSYDDLEDIAILAGALRK--QDVGPRNPLCATE-----LPGG 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  80 IRGVICLPPAVIDGTTAVAFRKDLAADKNLEQLTSEGIFSDCRKITGSKQSLTDDDFFLKELHSSEKWPAFLQTAVEKKR 159
Cdd:PRK13851  84 ERLQICLPPTVPSGTVSLTIRRPSSRVSELKEVSSRYDASRWNQWQERRKRRDQLDEAILRHYDNGDLEAFLHACVVGRL 163
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 160 TIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHVvEAVYMMYG-DAGKIGRVSATDALRACMRLTPGRIIM 238
Cdd:PRK13851 164 TMLLCGPTGSGKTTMSKTLISAIPPQERLITIEDTLELVIPHE-NHVRLLYSkNGAGLGAVTAEHLLQASLRMRPDRILL 242
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 239 TELRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDMSDIMRMLYSTIDVVV----HMEKRKIK 314
Cdd:PRK13851 243 GEMRDDAAWAYLSEVVSGHPGSISTIHGANPVQGFKKLFSLVKSSAQGASLEDRTLIDMLATAIDVIVpfraYGDVYEVG 322

                 ....*..
gi 446050741 315 EIYFDPE 321
Cdd:PRK13851 323 EIWLAAD 329
PRK13900 PRK13900
type IV secretion system ATPase VirB11; Provisional
9-318 2.31e-42

type IV secretion system ATPase VirB11; Provisional


Pssm-ID: 184381  Cd Length: 332  Bit Score: 149.52  E-value: 2.31e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   9 LGPLREYLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVSSnklTMQAIND------VILPGGIRG 82
Cdd:PRK13900  12 LEPLKNIFAEDGVNEISINKPGEVWVEKKGDIRCEQIPELDLSHLKALGRLVAQA---TEQKISEekpllsATLPNGYRI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  83 VICLPPAVIDGTTAVAFRKDLAADKNLEQLTSEGIFSDcrkiTGSKQSLTDDDFFLKELHSSEKWPAFLQTAVEKKRTIV 162
Cdd:PRK13900  89 QIVFPPACEIGQIVYSIRKPSGMQLTLDDYEKMGAFDE----TATESLVDEDDVILNELLAEKKIKEFLEHAVISKKNII 164
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 163 ICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHVVEAVYMMYGDAGKiGR--VSATDALRACMRLTPGRIIMTE 240
Cdd:PRK13900 165 ISGGTSTGKTTFTNAALREIPAIERLITVEDAREIVLSNHPNRVHLLASKGGQ-GRakVTTQDLIEACLRLRPDRIIVGE 243
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 241 LRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDmsDIMRMLYSTIDVVVHME-----KRKIKE 315
Cdd:PRK13900 244 LRGAEAFSFLRAINTGHPGSISTLHADSPAMAIEQLKLMVMQAGLGMPPD--QIKKYILNVVDIVVQLKrgsggKRYVSE 321

                 ...
gi 446050741 316 IYF 318
Cdd:PRK13900 322 IYF 324
heli_sec_ATPase TIGR03819
helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct ...
9-316 5.88e-34

helicase/secretion neighborhood ATPase; Members of this protein family comprise a distinct clade of putative ATPase associated with an integral membrane complex likely to act in pilus formation, secretion, or conjugal transfer. The association of most members with a nearby gene for a DEAH-box helicase suggests a role in conjugal transfer.


Pssm-ID: 200328  Cd Length: 340  Bit Score: 127.45  E-value: 5.88e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741    9 LGPLREYLEDPTVFEIRINCFQEVICDTFSGRRVVQNAAITADFIRNLAKSLVSS--NKL-TMQAINDVILPGGIRGVIC 85
Cdd:TIGR03819  52 AGPLEPLLADPGVTDVLVNGPDEVWVDRGRGLERTDVRFPDEAAVRRLAQRLAAAagRRLdDAQPWVDARLPDGTRLHAV 131
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   86 LPPAVIDGTtAVAFRKDLAADKNLEQLTSEGIFS-DCRKItgskqsltdddfflkelhssekwpafLQTAVEKKRTIVIC 164
Cdd:TIGR03819 132 LPPVATDGT-CLSLRVPRRRTFTLDELVAAGTIPpGVARL--------------------------LRALVAARLAFLVS 184
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  165 GETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDH--VVeAVYMMYGDAGKIGRVSATDALRACMRLTPGRIIMTELR 242
Cdd:TIGR03819 185 GGTGSGKTTLLSALLALVPPDERIVLVEDAAELRPDHphVV-RLEARPANVEGAGAVTLTDLVRQALRMRPDRIVVGEVR 263
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446050741  243 DDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLikATPIGrmLDMSDIMRMLYSTIDVVVHMEK-----RKIKEI 316
Cdd:TIGR03819 264 GAEVVDLLAALNTGHDGGAGTLHANSPADVPARLEAL--GALAG--LDRAALHSQLAAALDVVLHVRRtprgrRRVAEI 338
TrbB_P TIGR02782
P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of ...
9-316 2.22e-33

P-type conjugative transfer ATPase TrbB; The TrbB protein is found in the trb locus of Agrobacterium Ti plasmids where it is involved in the type IV secretion system for plasmid conjugative transfer. TrbB is a homolog of the vir system VirB11 ATPase, and the Flp pilus sytem ATPase TadA. [Cellular processes, Conjugation]


Pssm-ID: 274297  Cd Length: 299  Bit Score: 124.85  E-value: 2.22e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741    9 LGP-LREYLEDPTVFEIRINCFQEVICDTFSG--RRVVQNAAITADFIRNLAKSLVSSNKLTMQAINDVILP-GGIRGVI 84
Cdd:TIGR02782   6 LGPeIAAALDDPGVVEIMLNPDGRLWVERLGSgmSPLGEMSPADAQRIIGLVADYLGTEVDRDKPIVEGELPlDGSRFEG 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   85 CLPPAVidGTTAVAFRKDLAADKNLEQLTSEGIFSdcrkitgskqsltdddfflkelhssEKWPAFLQTAVEKKRTIVIC 164
Cdd:TIGR02782  86 LIPPVV--AAPSFAIRKKAVAVFTLDDYVEAGIMT-------------------------AAQRDVLREAVLARKNILVV 138
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  165 GETGSGKTVLTRALLKSLHK---DERVIILEDVHEVTVdHVVEAVYMMYGDagkiGRVSATDALRACMRLTPGRIIMTEL 241
Cdd:TIGR02782 139 GGTGSGKTTLANALLAEIAKndpTDRVVIIEDTRELQC-AAPNVVQLRTSD----DAISMTRLLKATLRLRPDRIIVGEV 213
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 446050741  242 RDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKatpigrMLDMSDIMRMLYSTIDVVVHMEK----RKIKEI 316
Cdd:TIGR02782 214 RGGEALDLLKAWNTGHPGGIATIHANNAKAALDRLEQLIQ------EVSVTPMQTLIAEAVDLVIFIARtpagRRVQEI 286
type_II_IV_secretion_ATPases cd19477
type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP ...
155-317 9.89e-26

type II/type IV hexameric secretion ATPases; RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H(+)ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and related DNA transfer proteins involved in type II and type IV secretion.


Pssm-ID: 410885 [Multi-domain]  Cd Length: 168  Bit Score: 100.93  E-value: 9.89e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 155 VEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHVVEAVYMMYGdagkiGRVSATDALRACMRLTPG 234
Cdd:cd19477    7 IAIGKNVIVCGGTGSGKTTYIKSILEFIPKEERIISIEDTEEIVFKHHKNYTQLFFG-----GNITSADCLKSCLRQRPD 81
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 235 RIIMTELRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLIKATPIGRMLDMSDIMRMLYSTIDVVVHME-KRKI 313
Cdd:cd19477   82 RIILGELRSSEAYDFYNVLCSGHKGTLTTLHAGSSEEAFIRLAN*SSSNSAARNIKFESLIEGFKDLIDGIVHINhHKQC 161

                 ....
gi 446050741 314 KEIY 317
Cdd:cd19477  162 DEFY 165
PRK13833 PRK13833
conjugal transfer protein TrbB; Provisional
149-276 3.49e-24

conjugal transfer protein TrbB; Provisional


Pssm-ID: 172360 [Multi-domain]  Cd Length: 323  Bit Score: 100.64  E-value: 3.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 149 AFLQTAVEKKRTIVICGETGSGKTVLTRALLKSLHK---DERVIILEDVHEVTVdHVVEAVYMMYGDAGKIGRVsatdaL 225
Cdd:PRK13833 135 SVIRSAIDSRLNIVISGGTGSGKTTLANAVIAEIVAsapEDRLVILEDTAEIQC-AAENAVALHTSDTVDMARL-----L 208
                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 446050741 226 RACMRLTPGRIIMTELRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRI 276
Cdd:PRK13833 209 KSTMRLRPDRIIVGEVRDGAALTLLKAWNTGHPGGVTTIHSNTAMSALRRL 259
PRK13894 PRK13894
conjugal transfer ATPase TrbB; Provisional
86-316 5.05e-24

conjugal transfer ATPase TrbB; Provisional


Pssm-ID: 184377  Cd Length: 319  Bit Score: 99.81  E-value: 5.05e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  86 LPPAVIDGTTAVafRKDLAADKNLEQLTSEGIFSDCRKitgskqsltdddfflkelhssekwpAFLQTAVEKKRTIVICG 165
Cdd:PRK13894 103 LPPVVPAPTFAI--RKKAVAIFTLDQYVERGIMTAAQR-------------------------EAIIAAVRAHRNILVIG 155
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 166 ETGSGKTVLTRALLKSLHK---DERVIILEDVHEV--TVDHVVEavYMMYGDagkigrVSATDALRACMRLTPGRIIMTE 240
Cdd:PRK13894 156 GTGSGKTTLVNAIINEMVIqdpTERVFIIEDTGEIqcAAENYVQ--YHTSID------VNMTALLKTTLRMRPDRILVGE 227
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 241 LRDDAAWDYLKALNTGHPGGVMSTHANSARDAFNRIGLLI---KATPigrmldmSDIMRMLYSTIDVVVHMEK----RKI 313
Cdd:PRK13894 228 VRGPEALDLLMAWNTGHEGGAATLHANNAKAGLDRLKSLIsmhPDAP-------KPIEPLIGEAVHVVVHIARtpggRRI 300

                 ...
gi 446050741 314 KEI 316
Cdd:PRK13894 301 QEI 303
VirB11 COG0630
Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell ...
149-317 3.22e-21

Type IV secretory pathway ATPase VirB11/Archaellum biosynthesis ATPase ArlI/FlaI [Cell motility, Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440395 [Multi-domain]  Cd Length: 462  Bit Score: 93.61  E-value: 3.22e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 149 AFLQTAVEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHvvEAVYMMY---GDAGKIGRVSATDAL 225
Cdd:COG0630  281 AYLWLLLENGKSVLVAGGTASGKTTLLNALLSFIPPDAKIVTIEDTRELNLPH--ENWISLVtreSFGGEEGDVTMFDLL 358
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 226 RACMRLTPGRIIMTELRDDAAWDYLKALNTGHpgGVMST-HANSARDAFNRigllIKATPIGrmldmsdIMRMLYSTIDV 304
Cdd:COG0630  359 KAALRQRPDYIVVGEVRGEEAYTLFQAMATGH--GVLSTfHADSVESAINR----LTSPPIN-------VPRTLLQALDL 425
                        170       180
                 ....*....|....*....|.
gi 446050741 305 VVHMEK--------RKIKEIY 317
Cdd:COG0630  426 VVFQKRvrvggkrvRRVTSIV 446
T2SSE pfam00437
Type II/IV secretion system protein; This family contains components of both the Type II ...
149-306 1.66e-20

Type II/IV secretion system protein; This family contains components of both the Type II protein secretion system (T2SS), including Type 4 pilus (T4P), and Type IV protein secretion system (T4SS) from Gram-negative bacteria. VirB11 ATPase is a subunit of the Agrobacterium tumefaciens transfer DNA (T-DNA) transfer system, a type IV secretion pathway required for delivery of T-DNA and effector proteins to plant cells during infection. The cytoplasmic T2S E ATPase is a Zn-containing protein thought to provide the mechanical force for the secretion process. T2S-E contains Walker A and B motifs, that are essential for secretion and ATPase activity. ATPase PulE and XcpR from Klebsiella oxytoca and Pseudomonas aeruginosa respectively are required for protein secretion via the T2SS. ATPase PilB is required for T4P extension.


Pssm-ID: 425681 [Multi-domain]  Cd Length: 269  Bit Score: 89.27  E-value: 1.66e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  149 AFLQTAvekKRTIVICGETGSGKTVLTRALLKSLHK-DERVIILEDVHEVTVDHV----VEAVymmygdagkiGRVSATD 223
Cdd:pfam00437 124 EFLRQP---RGNILVTGPTGSGKTTTLYAALGELNTrDENIVTVEDPVEIQLEGInqvqLNAR----------AGVTFAD 190
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  224 ALRACMRLTPGRIIMTELRD-DAAWDYLKALNTGHPggVMST-HANSARDAfnrigllikatpIGRMLDMSDIMRMLYST 301
Cdd:pfam00437 191 LLRAILRQDPDRIMVGEIRDlETAEIALQAANTGHL--VLSTlHTNSAAGA------------LTRLQDMGVPPFELASS 256

                  ....*
gi 446050741  302 IDVVV 306
Cdd:pfam00437 257 LLLVI 261
DotB_TraJ cd19516
dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of ...
148-298 5.25e-12

dot/icm secretion system protein DotB-like; Defect in organelle trafficking (Dot)B is part of the type IVb secretion (T4bS) system, also known as the dot/icm system, and is the main energy supplier of the secretion system. It is an ATPase, similar to the VirB11 component of the T4aS systems. This family also includes Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ encoded on the tra (transfer) operon.


Pssm-ID: 410924 [Multi-domain]  Cd Length: 179  Bit Score: 63.55  E-value: 5.25e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 148 PAFLQTAVEKKRTIVICGETGSGKTVL----TRALLKSLHKDERVIILEDVHEVTVDHVVEAVYMMYgdAGKIGR--VSA 221
Cdd:cd19516    1 PDLVEALFPREGLVYVAGATGSGKSTLlaaiYRYILENDPPDRKIITYEDPIEFVYDGIKSKHSIIV--QSQIPRhfKSF 78
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 222 TDALRACMRLTPGRIIMTELRD----DAAwdyLKALNTGHPggVMST-HANSARDAFNRiglLIKATP----IGRMLDMS 292
Cdd:cd19516   79 AKAVREALRRKPSLIGVGELRDqetiSAA---VEASLTGHP--VYSTvHTKSVAETIRR---LISLFPpeerDAAAYDLL 150

                 ....*.
gi 446050741 293 DIMRML 298
Cdd:cd19516  151 STLRFI 156
PulE-GspE-like cd01129
PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II ...
161-291 1.62e-11

PulE-GspE family; PulE and General secretory pathway protein GspE are ATPases of the type II secretory pathway, the main terminal branch of the general secretory pathway (GSP). PulE is a cytoplasmic protein of the GSP, which contains an ATP binding site and a tetracysteine motif. This subgroup also includes PilB, a type IV pilus assembly ATPase, DotB, an ATPase of the type IVb secretion system, also known as the dot/icm system, Escherichia coli IncI plasmid-encoded conjugative transfer ATPase TraJ, and HofB.


Pssm-ID: 410873 [Multi-domain]  Cd Length: 159  Bit Score: 61.73  E-value: 1.62e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 161 IVICGETGSGKTVLTRALLKSLHKDERVIIledvhevTVDHVVEavymmYGDAG--------KIGRVSAtDALRACMRLT 232
Cdd:cd01129   14 ILVTGPTGSGKTTTLYAMLRELNGPERNII-------TIEDPVE-----YQIPGinqsqvneKIGLTFA-DALRAILRQD 80
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446050741 233 PgRIIMT-ELRD----DAAwdyLKALNTGHPggVMST-HANSARDAfnrigllikatpIGRMLDM 291
Cdd:cd01129   81 P-DIIMVgEIRDaetaEIA---IRAALTGHL--VLSTlHTNDALGA------------ITRLLDM 127
PilT cd01131
Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein ...
148-276 1.56e-07

Pilus retraction ATPase PilT; Pilus retraction ATPase PilT is a nucleotide-binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism known as twitching motility.


Pssm-ID: 410875 [Multi-domain]  Cd Length: 223  Bit Score: 51.38  E-value: 1.56e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 148 PAFLQTAVEKKRTIVICGETGSGKTVLTRALLKSL--HKDERVIILED----VH----------EVTVDhvveavymmyg 211
Cdd:cd01131   11 PVLKDLALKPRGLVLVTGPTGSGKSTTLAAMIDYIneTRSKHIITIEDpiefVHkhkkslinqrEVGRD----------- 79
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 212 dagkigRVSATDALRACMRLTPGRIIMTELRD----DAAwdyLKALNTGHPggVMST-HANSARDAFNRI 276
Cdd:cd01131   80 ------TESFAAALRAALREDPDVILVGEMRDletiELA---LTAAETGHL--VFSTlHTNSAAQTIDRI 138
PulE COG2804
Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell ...
161-291 1.82e-07

Type II secretory pathway ATPase GspE/PulE or T4P pilus assembly pathway ATPase PilB [Cell motility, Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442055 [Multi-domain]  Cd Length: 561  Bit Score: 52.50  E-value: 1.82e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 161 IVICGETGSGKTVLTRALLKSLHKDERVII-LED--------VHEVTVDHvveavymmygdagKIGRVSAtDALRACMRL 231
Cdd:COG2804  316 ILVTGPTGSGKTTTLYAALNELNTPERNIItVEDpveyqlpgINQVQVNP-------------KIGLTFA-SALRSILRQ 381
                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446050741 232 TPGrIIMT-ELRD----DAAwdyLKALNTGHpgGVMST-HANSARDAfnrigllikatpIGRMLDM 291
Cdd:COG2804  382 DPD-VIMVgEIRDletaEIA---VQAALTGH--LVLSTlHTNDAPSA------------ITRLLDM 429
PilT COG2805
Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular ...
148-276 5.83e-07

Type IV pilus assembly protein PilT, pilus retraction ATPase [Cell motility, Extracellular structures];


Pssm-ID: 442056  Cd Length: 342  Bit Score: 50.48  E-value: 5.83e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741 148 PAFLQTAVEKKRTIV-ICGETGSGKTVLTRALLKSL--HKDERVIILED----VH----------EVTVDHVveavymmy 210
Cdd:COG2805  114 PPVLKELAELPRGLVlVTGPTGSGKSTTLAAMIDYIneTRAKHIITIEDpiefVHkhkkslinqrEVGRDTP-------- 185
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446050741 211 gdagkigrvSATDALRACMRLTPGRIIMTELRD----DAAwdyLKALNTGHPggVMST-HANSARDAFNRI 276
Cdd:COG2805  186 ---------SFANALRAALREDPDVILVGEMRDletiEAA---LTAAETGHL--VFATlHTNSAAQTIDRI 242
AAA cd00009
The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily ...
156-204 5.75e-05

The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, RecA-like, VirD4-like, PilT-like, and SF1/2 helicases. Members of the AAA+ ATPases function as molecular chaperons, ATPase subunits of proteases, helicases, or nucleic-acid stimulated ATPases. The AAA+ proteins contain several distinct features in addition to the conserved alpha-beta-alpha core domain structure and the Walker A and B motifs of the P-loop NTPases.


Pssm-ID: 99707 [Multi-domain]  Cd Length: 151  Bit Score: 42.52  E-value: 5.75e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 446050741 156 EKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHVVE 204
Cdd:cd00009   17 PPPKNLLLYGPPGTGKTTLARAIANELFRPGAPFLYLNASDLLEGLVVA 65
ExeA COG3267
Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, ...
161-230 1.56e-04

Type II secretory pathway ATPase component GspA/ExeA/MshM [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 442498 [Multi-domain]  Cd Length: 261  Bit Score: 42.47  E-value: 1.56e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 446050741 161 IVICGETGSGKTVLTRALLKSLHKDERVIILEDVHeVTVDHVVEAVYMMYG-DAGKIGRVSATDALRACMR 230
Cdd:COG3267   46 VVLTGEVGTGKTTLLRRLLERLPDDVKVAYIPNPQ-LSPAELLRAIADELGlEPKGASKADLLRQLQEFLL 115
AAA smart00382
ATPases associated with a variety of cellular activities; AAA - ATPases associated with a ...
157-237 2.90e-04

ATPases associated with a variety of cellular activities; AAA - ATPases associated with a variety of cellular activities. This profile/alignment only detects a fraction of this vast family. The poorly conserved N-terminal helix is missing from the alignment.


Pssm-ID: 214640 [Multi-domain]  Cd Length: 148  Bit Score: 40.43  E-value: 2.90e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   157 KKRTIVICGETGSGKTVLTRALLKSLHKDE-RVIILEDVHEVTVDHVVEAVYMMYGDAGKIGRVSATDALRACMRLTPGR 235
Cdd:smart00382   1 PGEVILIVGPPGSGKTTLARALARELGPPGgGVIYIDGEDILEEVLDQLLLIIVGGKKASGSGELRLRLALALARKLKPD 80

                   ..
gi 446050741   236 II 237
Cdd:smart00382  81 VL 82
AAA_7 pfam12775
P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 ...
150-190 4.07e-04

P-loop containing dynein motor region; This domain is found in human cytoplasmic dynein-2 proteins. Cytoplasmic dynein-2 (dynein-2) performs intraflagellar transport and is associated with human skeletal ciliopathies. Dyneins share a conserved motor domain that couples cycles of ATP hydrolysis with conformational changes to produce movement. Structural analysis reveal that the motor's ring consists of six AAA+ domains (ATPases associated with various cellular activities (AAA1-AAA6). This is the third nucleotide binding sites in the dynein motor. However, AAA3 has lost the catalytic residues necessary for ATP hydrolysis (the Walker B glutamate, the arginine finger, sensor-I and sensor-II motifs).


Pssm-ID: 463698 [Multi-domain]  Cd Length: 179  Bit Score: 40.45  E-value: 4.07e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 446050741  150 FLQTAVEKKRTIVICGETGSGKTVLTRALLKSLHKDERVII 190
Cdd:pfam12775  23 LLDLLLKNGKPVLLVGPTGTGKTVIIQNLLRKLDKEKYLPL 63
AAA_2 pfam07724
AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected ...
160-203 4.11e-04

AAA domain (Cdc48 subfamily); This Pfam entry includes some of the AAA proteins not detected by the pfam00004 model.


Pssm-ID: 400187 [Multi-domain]  Cd Length: 168  Bit Score: 40.26  E-value: 4.11e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 446050741  160 TIVICGETGSGKTVLTRALLKSLHKDERVIILEDVHEVTVDHVV 203
Cdd:pfam07724   5 SFLFLGPTGVGKTELAKALAELLFGDERALIRIDMSEYMEEHSV 48
AAA_22 pfam13401
AAA domain;
161-231 4.37e-04

AAA domain;


Pssm-ID: 379165 [Multi-domain]  Cd Length: 129  Bit Score: 39.63  E-value: 4.37e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 446050741  161 IVICGETGSGKTVLTRALLKSLHKDE-RVIILEDVHEVTVDHVVEAVYMMYGDAGKiGRVSATDALRACMRL 231
Cdd:pfam13401   8 LVLTGESGTGKTTLLRRLLEQLPEVRdSVVFVDLPSGTSPKDLLRALLRALGLPLS-GRLSKEELLAALQQL 78
plasmid_TraJ TIGR02525
plasmid transfer ATPase TraJ; Members of this protein family are predicted ATPases associated ...
163-275 1.31e-03

plasmid transfer ATPase TraJ; Members of this protein family are predicted ATPases associated with plasmid transfer loci in bacteria. This family is most similar to the DotB ATPase of a type-IV secretion-like system of obligate intracellular pathogens Legionella pneumophila and Coxiella burnetii (TIGR02524). [Mobile and extrachromosomal element functions, Plasmid functions]


Pssm-ID: 131577 [Multi-domain]  Cd Length: 372  Bit Score: 40.17  E-value: 1.31e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741  163 ICGETGSGKTVLTRALLKSLHK---DERVIILEDVHEvtvdhvveavYMMYGD-------AGKIGR--VSATDALRACMR 230
Cdd:TIGR02525 154 ICGETGSGKSTLAASIYQHCGEtypDRKIVTYEDPIE----------YILGSPddllppaQSQIGRdvDSFANGIRLALR 223
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 446050741  231 LTPGRIIMTELRD----DAAwdyLKALNTGHpgGVMST-HANSARDAFNR 275
Cdd:TIGR02525 224 RAPKIIGVGEIRDletfQAA---VLAGQSGH--FCLGTlHVKSPGEAISR 268
DEXDc smart00487
DEAD-like helicases superfamily;
151-239 1.32e-03

DEAD-like helicases superfamily;


Pssm-ID: 214692 [Multi-domain]  Cd Length: 201  Bit Score: 39.40  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446050741   151 LQTAVEKKRTIVICGETGSGKT-VLTRALLKSLHKDE--RVIILEDVHEVTVDHVVEAVYMMYGDAGK----IGRVSATD 223
Cdd:smart00487  17 IEALLSGLRDVILAAPTGSGKTlAALLPALEALKRGKggRVLVLVPTRELAEQWAEELKKLGPSLGLKvvglYGGDSKRE 96
                           90
                   ....*....|....*.
gi 446050741   224 ALRACMRLTPGRIIMT 239
Cdd:smart00487  97 QLRKLESGKTDILVTT 112
HerA COG0433
Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase ...
159-195 5.09e-03

Archaeal DNA helicase HerA or a related bacterial ATPase, contains HAS-barrel and ATPase domains [Replication, recombination and repair];


Pssm-ID: 440202 [Multi-domain]  Cd Length: 388  Bit Score: 38.43  E-value: 5.09e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 446050741 159 RTIVICGETGSGKTVLTRALLKSLHKDE-RVIILeDVH 195
Cdd:COG0433   48 RHILILGATGSGKSNTLQVLLEELSRAGvPVLVF-DPH 84
TsaE pfam02367
Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in ...
162-188 5.57e-03

Threonylcarbamoyl adenosine biosynthesis protein TsaE; This family of proteins is involved in the synthesis of threonylcarbamoyl adenosine (t(6)A).


Pssm-ID: 460540  Cd Length: 127  Bit Score: 36.26  E-value: 5.57e-03
                          10        20
                  ....*....|....*....|....*....
gi 446050741  162 VIC--GETGSGKTVLTRALLKSLHKDERV 188
Cdd:pfam02367  23 VILlsGDLGAGKTTFTRGLARGLGVTGPV 51
PRK11784 PRK11784
tRNA 2-selenouridine synthase; Provisional
149-178 6.11e-03

tRNA 2-selenouridine synthase; Provisional


Pssm-ID: 236982 [Multi-domain]  Cd Length: 345  Bit Score: 37.89  E-value: 6.11e-03
                         10        20        30
                 ....*....|....*....|....*....|
gi 446050741 149 AFLQTAVEKKRTIVICGETGSGKTVLTRAL 178
Cdd:PRK11784 132 DTLEEAPAQFPLVVLGGNTGSGKTELLQAL 161
AcoR COG3284
Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];
154-178 7.47e-03

Transcriptional regulator DhaR of acetoin/glycerol metabolism [Transcription];


Pssm-ID: 442514 [Multi-domain]  Cd Length: 625  Bit Score: 37.96  E-value: 7.47e-03
                         10        20
                 ....*....|....*....|....*
gi 446050741 154 AVEKKRTIVICGETGSGKTVLTRAL 178
Cdd:COG3284  340 LADRDIPVLILGETGTGKELFARAI 364
cobW pfam02492
CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase ...
160-200 7.56e-03

CobW/HypB/UreG, nucleotide-binding domain; This domain is found in HypB, a hydrogenase expression / formation protein, and UreG a urease accessory protein. Both these proteins contain a P-loop nucleotide binding motif. HypB has GTPase activity and is a guanine nucleotide binding protein. It is not known whether UreG binds GTP or some other nucleotide. Both enzymes are involved in nickel binding. HypB can store nickel and is required for nickel dependent hydrogenase expression. UreG is required for functional incorporation of the urease nickel metallocenter. GTP hydrolysis may required by these proteins for nickel incorporation into other nickel proteins. This family of domains also contains P47K, a Pseudomonas chlororaphis protein needed for nitrile hydratase expression, and the cobW gene product, which may be involved in cobalamin biosynthesis in Pseudomonas denitrificans.


Pssm-ID: 396860  Cd Length: 179  Bit Score: 36.85  E-value: 7.56e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 446050741  160 TIVICGETGSGKTVLTRALLKSLHKDERV-IILEDVHEVTVD 200
Cdd:pfam02492   2 VTVITGFLGSGKTTLLNHLLKQNRAGLRIaVIVNEFGETGID 43
ABC_NikE_OppD_transporters cd03257
ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter ...
155-193 8.52e-03

ATP-binding cassette domain of nickel/oligopeptides specific transporters; The ABC transporter subfamily specific for the transport of dipeptides, oligopeptides (OppD), and nickel (NikDE). The NikABCDE system of E. coli belongs to this family and is composed of the periplasmic binding protein NikA, two integral membrane components (NikB and NikC), and two ATPase (NikD and NikE). The NikABCDE transporter is synthesized under anaerobic conditions to meet the increased demand for nickel resulting from hydrogenase synthesis. The molecular mechanism of nickel uptake in many bacteria and most archaea is not known. Many other members of this ABC family are also involved in the uptake of dipeptides and oligopeptides. The oligopeptide transport system (Opp) is a five-component ABC transport composed of a membrane-anchored substrate binding proteins (SRP), OppA, two transmembrane proteins, OppB and OppC, and two ATP-binding domains, OppD and OppF.


Pssm-ID: 213224 [Multi-domain]  Cd Length: 228  Bit Score: 37.10  E-value: 8.52e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 446050741 155 VEKKRTIVICGETGSGKTVLTRALLKSLHKDERVIILED 193
Cdd:cd03257   28 IKKGETLGLVGESGSGKSTLARAILGLLKPTSGSIIFDG 66
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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