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Conserved domains on  [gi|446047327|ref|WP_000125182|]
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MULTISPECIES: iron-dicitrate ABC transporter permease FecC [Enterobacteriaceae]

Protein Classification

iron-dicitrate ABC transporter permease FecC( domain architecture ID 10793551)

iron-dicitrate ABC transporter permease FecC is part of the binding-protein-dependent transport system for citrate-dependent Fe(3+), and may be responsible for the translocation of the substrate across the membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
10-332 3.34e-158

iron-dicitrate ABC transporter permease FecC;


:

Pssm-ID: 183042  Cd Length: 323  Bit Score: 445.29  E-value: 3.34e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  10 LWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPM 89
Cdd:PRK11228   1 LWGLPVAALIGLFWLSLFCYSAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  90 ASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVGWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRI 169
Cdd:PRK11228  81 ASPSLLGINSGAALAMALTSALSPTPFAGYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 170 TLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLL 249
Cdd:PRK11228 161 TLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 250 VGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVR 329
Cdd:PRK11228 241 VGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLAR 320


                 ...
gi 446047327 330 RRG 332
Cdd:PRK11228 321 RRG 323
 
Name Accession Description Interval E-value
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
10-332 3.34e-158

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 445.29  E-value: 3.34e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  10 LWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPM 89
Cdd:PRK11228   1 LWGLPVAALIGLFWLSLFCYSAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  90 ASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVGWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRI 169
Cdd:PRK11228  81 ASPSLLGINSGAALAMALTSALSPTPFAGYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 170 TLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLL 249
Cdd:PRK11228 161 TLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 250 VGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVR 329
Cdd:PRK11228 241 VGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLAR 320


                 ...
gi 446047327 330 RRG 332
Cdd:PRK11228 321 RRG 323
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 31-332 3.69e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 243.82  E-value: 3.69e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  31 AIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSA 110
Cdd:COG0609    6 AVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 111 LSPTpIAGYSLSFIAACGGGVGWLLVMTAGGGFRHThDRNKLILAGIALSAFCMGLTRITLLLA-EDHAYGIFYWLAGGV 189
Cdd:COG0609   86 LGGG-LSALGLPLAAFLGALLAALLVYLLARRGGGL-SPLRLVLAGVAVSALFSALTSLLLLLAdPEQLRSIVFWLMGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 190 SHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPH 269
Cdd:COG0609  164 AGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446047327 270 LARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG 332
Cdd:COG0609  244 IARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 17-330 8.44e-66

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 209.69  E-value: 8.44e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   17 ALIIIFWLSLFcYSAIPVSGADATRALLPGHTPTLpEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLG 96
Cdd:pfam01032   1 LLLLLILLSLF-IGAVKISPSDVFSALLGGDDSLA-ALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   97 INSGAALAMALtSALSPTPIAGYSLSFIAACGGGVGWLLVMTAGGGFRHThDRNKLILAGIALSAFCMGLTR-ITLLLAE 175
Cdd:pfam01032  79 ISSGAALGAVL-AILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGA-SPLRLILAGIAVSALLSALTSlLLLLLNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  176 DHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVS 255
Cdd:pfam01032 157 EALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVA 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446047327  256 VAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRR 330
Cdd:pfam01032 237 VVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 65-328 3.07e-48

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 162.73  E-value: 3.07e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  65 LVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAgYSLSFIAACGGGVGWLLVMTAGggFR 144
Cdd:cd06550    2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSN-YALGAFAFAGALAIALLVLLLA--SR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 145 HTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLS 224
Cdd:cd06550   79 GGLSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 225 DSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARAL 304
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 446047327 305 aFPGDLPAGAVLALIGSPCFVWLV 328
Cdd:cd06550  239 -LPSELPVGPVTALLGAPYFLYLL 261
 
Name Accession Description Interval E-value
fecC PRK11228
iron-dicitrate ABC transporter permease FecC;
10-332 3.34e-158

iron-dicitrate ABC transporter permease FecC;


Pssm-ID: 183042  Cd Length: 323  Bit Score: 445.29  E-value: 3.34e-158
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  10 LWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPM 89
Cdd:PRK11228   1 LWGLPVAALIGLFWLSLFCYSAIPISAADALNALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGALLQTLTHNPL 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  90 ASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVGWLLVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRI 169
Cdd:PRK11228  81 ASPSLLGINSGAALAMALTSALSPTPFAGYSLAFIAACGGGLSWLLVMTAGGGWRHTHDRNRLILAGIALSALCMALTRI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 170 TLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLL 249
Cdd:PRK11228 161 TLLLAEDHAYGIFYWLAGGVSHARWQEVWQLLPFVVTAVPVVLLLANQLNLLNLSDSSAHTLGVNLTRLRLVVNMLVLLL 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 250 VGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVR 329
Cdd:PRK11228 241 VGACVSVAGPVAFIGLLVPHLARFWIGYDQRNVLPMSMLLGATLMLLADLLARALAFPGELPAGAVLALIGAPCFVWLAR 320


                 ...
gi 446047327 330 RRG 332
Cdd:PRK11228 321 RRG 323
FepD COG0609
ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and ...
 31-332 3.69e-79

ABC-type Fe3+-siderophore transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 440374  Cd Length: 306  Bit Score: 243.82  E-value: 3.69e-79
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  31 AIPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSA 110
Cdd:COG0609    6 AVPISLSDVLRALLGPDGDPTADLIVWDLRLPRVLLALLVGAALAVAGALMQGLTRNPLADPGILGVSSGAALGAVLAIV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 111 LSPTpIAGYSLSFIAACGGGVGWLLVMTAGGGFRHThDRNKLILAGIALSAFCMGLTRITLLLA-EDHAYGIFYWLAGGV 189
Cdd:COG0609   86 LGGG-LSALGLPLAAFLGALLAALLVYLLARRGGGL-SPLRLVLAGVAVSALFSALTSLLLLLAdPEQLRSIVFWLMGSL 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 190 SHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPH 269
Cdd:COG0609  164 AGASWDDVLLLLPVLLIGLLLALLLARALNALALGDETARSLGVNVERLRLLLLLLAALLTGAAVAVAGPIGFVGLVVPH 243

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 446047327 270 LARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG 332
Cdd:COG0609  244 IARLLVGPDHRRLLPASALLGALLLLLADTLARTILAPAELPVGIVTALIGAPFFLYLLRRRR 306
FecCD pfam01032
FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport ...
 17-330 8.44e-66

FecCD transport family; This is a sub-family of bacterial binding protein-dependent transport systems family. This Pfam entry contains the inner components of this multicomponent transport system.


Pssm-ID: 426003  Cd Length: 311  Bit Score: 209.69  E-value: 8.44e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   17 ALIIIFWLSLFcYSAIPVSGADATRALLPGHTPTLpEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLG 96
Cdd:pfam01032   1 LLLLLILLSLF-IGAVKISPSDVFSALLGGDDSLA-ALIVLDLRLPRVLAALLVGAALAVSGALLQTVTRNPLADPSILG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   97 INSGAALAMALtSALSPTPIAGYSLSFIAACGGGVGWLLVMTAGGGFRHThDRNKLILAGIALSAFCMGLTR-ITLLLAE 175
Cdd:pfam01032  79 ISSGAALGAVL-AILLGGSLSLFALPLAAFIGALLAALLVYFLSRGRGGA-SPLRLILAGIAVSALLSALTSlLLLLLNP 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  176 DHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVS 255
Cdd:pfam01032 157 EALQSILFWLMGSLSGANWSDVLILLPLLLIGLILLLLLARKLNLLSLGDDTAKSLGVNVNRVRLLLLLLASLLTAASVA 236

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 446047327  256 VAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRR 330
Cdd:pfam01032 237 VVGPIGFVGLIVPHIARLLVGANHRRLLPLSALLGALLLLLADILARTILSPYELPVGIVTALIGAPFFIYLLLR 311
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
54-332 4.22e-52

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 181.96  E-value: 4.22e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  54 ALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGySLSFIAACGGGVGW 133
Cdd:PRK10577 391 DALLPLRLPRLLAALLAGAMLAVAGTLLQRLTRNPLASPEVLGISSGAGLGVVLALFLVPGAGFG-WLLAAALLGALAAL 469

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 134 LLVMTAGGgfRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLL 213
Cdd:PRK10577 470 ALILLLAR--RGGFAPERLLLTGIALSALFTALIQLLLASGDPRAAQLLTWLSGSTYGVTWAQALPLLIVAVLLLALALL 547

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 214 LANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATL 293
Cdd:PRK10577 548 LRRWLDLLPLGDDTARALGLPVTRARLALLLLAALLTAAATATVGPLSFVGLMAPHLARMLGGRRARPQLVLAALLGALL 627

                        250       260       270
                 ....*....|....*....|....*....|....*....
gi 446047327 294 MLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG 332
Cdd:PRK10577 628 MVLADWLGRTLLFPYQIPAGLLAALIGAPYFLWLLRRSR 666
FepG COG4779
ABC-type enterobactin transport system, permease component [Inorganic ion transport and ...
 8-331 6.59e-49

ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism];


Pssm-ID: 443810  Cd Length: 344  Bit Score: 166.83  E-value: 6.59e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   8 VLLWGLPVAALIIIFWLSLFCYSAIPVSGADATRALLpGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHN 87
Cdd:COG4779   22 ALLVTLVLLLLLLALAVLALTLGDYPLSPGDVLRALL-GEGDPGASFVVLELRLPRALAALLVGAALGLSGAIFQSLTRN 100

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  88 PMASPSLLGINSGAALAMALTSALSPTpiAGYSLSFIAACGGGVGWLLV-MTAGGGFRHTHdrnKLILAGIALSAFCMGL 166
Cdd:COG4779  101 PLASPDIIGITAGASAGAVAAIVVLGG--SGLAVALGALAGGLATALLVyLLAWRGGVSGY---RLILVGIGVSAMLTAV 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 167 TRITLLLAE-DHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINML 245
Cdd:COG4779  176 NSYLLTRADlEDAQSAAVWLTGSLNGRTWEDVLPLAVALAVLLPLALALARRLRLLELGDDTAAALGVRVERTRLLLLLV 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 246 VLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPvSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFV 325
Cdd:COG4779  256 AVALAAVATAAAGPIAFVALAAPQIARRLTRSPGPPLLP-SALVGALLLLAADLVAQHLLAPVQLPVGVVTGALGGPYLL 334


                 ....*.
gi 446047327 326 WLVRRR 331
Cdd:COG4779  335 WLLIRE 340
TM_ABC_iron-siderophores_like cd06550
Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding ...
 65-328 3.07e-48

Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of a PBP, two TMs, and two cytoplasmic ABCs, and are mainly involved in importing solutes from the environment. The solute is captured by the PBP which delivers it to a gated translocation pathway formed by the two TMs. The TMs are bundles of alpha helices that transverse the cytoplasmic membrane multiple times. The two ABCs bind and hydrolyze ATP and drive the transport reaction. Each TM has a prominent cytoplasmic loop which contacts an ABC and represents a conserved motif. The two TMs form either a homodimer (e.g. in the case of the BtuC subunits of the Escherichia coli BtuCD vitamin B12 transporter), a heterodimer (e.g. the TroC and TroD subunits of the Treponema pallidum general transition metal transporter, TroBCD), or a pseudo-heterodimer (e.g. the FhuB protein of the E. coli ferrichrome transporter, FhuBC). FhuB contains two tandem TMs which associate to form the pseudo-heterodimer. Both FhuB TMs are found in this hierarchy.


Pssm-ID: 119348 [Multi-domain]  Cd Length: 261  Bit Score: 162.73  E-value: 3.07e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  65 LVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAgYSLSFIAACGGGVGWLLVMTAGggFR 144
Cdd:cd06550    2 LAALLVGAALAVSGAILQSLTRNRLASPSILGISHGALLGVVLALLLGIGLSN-YALGAFAFAGALAIALLVLLLA--SR 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 145 HTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLS 224
Cdd:cd06550   79 GGLSPSKLILIGIVLSAFFSAGVILISLLSDDSLQDLNIWLFGSILGVTWEDLLILLIILLLVLLLLLLLSRKLNLLTFD 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 225 DSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARAL 304
Cdd:cd06550  159 EDLAKSLGINVNLLRLLLLLLVALLVVAAVALVGVILFVGLIAPHLARRLFGRSHRYLLPLSALLGAILLLLGDLLSRTL 238

                        250       260
                 ....*....|....*....|....
gi 446047327 305 aFPGDLPAGAVLALIGSPCFVWLV 328
Cdd:cd06550  239 -LPSELPVGPVTALLGAPYFLYLL 261
BtuC COG4139
ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and ...
 55-332 4.30e-47

ABC-type cobalamin transport system, permease component BtuC [Coenzyme transport and metabolism];


Pssm-ID: 443314  Cd Length: 327  Bit Score: 161.56  E-value: 4.30e-47
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  55 LVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAAcgggVGWL 134
Cdd:COG4139   50 FVWQLRLPRTLAAVLVGASLAVSGAVMQALFENPLAEPGLLGISNGAGVGLVLVVLLGGGLLPPWLLSLAAI----AGAL 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 135 LVMTAGGGFRHTHDRN-KLILAGIALSAFCMGLTRITLLLAEDHAY-GIFYWLAGGVSHARWQDVWqLLPVVVTAVPVVL 212
Cdd:COG4139  126 LVTLLLLAFARRRLSNaRLLLIGVALGIICSAIMTWAVYFSSSLDLrQLMYWMMGSFGGVDWRQLW-LLLALLPVLLWLC 204

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 213 LLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGAT 292
Cdd:COG4139  205 LQGKPLNLLLLGENQARQLGLSVHRWRNLLVLATGLLVGVSVALAGPIGFVGLVVPHLLRLLGTTDHRFLLPACALAGAA 284

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446047327 293 LMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRRG 332
Cdd:COG4139  285 LLLLADIIARLALSSAELPIGVVTATLGAPVFIWLLLRRR 324
PRK10577 PRK10577
Fe(3+)-hydroxamate ABC transporter permease FhuB;
1-330 1.08e-46

Fe(3+)-hydroxamate ABC transporter permease FhuB;


Pssm-ID: 236720 [Multi-domain]  Cd Length: 668  Bit Score: 167.32  E-value: 1.08e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   1 MTAIKHPVLLWGLPVAALIIIFWLSLFCYSAiPVSGADATRALLPGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTL 80
Cdd:PRK10577   4 LMSRRRARLPALLLALLLLLALALTLTQLSA-ALPLSQWLQALWGPDADDLEQLLLHYSRLPRLAIALLVGAALGLAGAL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  81 LQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLsFIAACGGGVGWLLVMTAGGGFRHTHDRnkLILAGIALS 160
Cdd:PRK10577  83 LQQVLRNPLASPTTLGVAAGAQLALVLATLFAPALLALASQ-LAAFAGGLLAAALVFALAGGKRLSPLR--LVLAGMVVS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 161 AFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRL 240
Cdd:PRK10577 160 LYLGALTTLLLLFNEQYLQGLFLWGAGSLAQNDWSGVQRLLPRLLVGLLLLLLLARPLTLLGLGDDVARSLGLAVSLTRL 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 241 VINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPG--DLPAGAVLAL 318
Cdd:PRK10577 240 AALALAVLLSAAVVSAVGPIGFIGLAAPNLARLLGARRLRARLPLSPLIGALLLLLTDQLVRLLAGVGgeLLPTGAVTAL 319

                        330
                 ....*....|..
gi 446047327 319 IGSPCFVWLVRR 330
Cdd:PRK10577 320 IGAPLLLWLLPR 331
PRK03784 PRK03784
vtamin B12-transporter permease; Provisional
 55-331 5.72e-41

vtamin B12-transporter permease; Provisional


Pssm-ID: 235159  Cd Length: 331  Bit Score: 145.87  E-value: 5.72e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  55 LVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFIAACGGGVGWL 134
Cdd:PRK03784  53 FVWQLRLPRTLAVLLVGAALAVSGAVMQALFENPLAEPGLLGVSNGAGVALVAAVLLGQGLLPPWALSLCAIAGALLITL 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 135 LVMtaggGFRHTHDRN--KLILAGIALSAFCMGLTRITLLLAEDHAY-GIFYWLAGGVSHARWQDVWqLLPVVVTAVPVV 211
Cdd:PRK03784 133 ILL----RFARRHRLStsRLLLAGVALGIICSALMTWAVYFSTSLDLrQLMYWMMGGFGGVDWRQSW-LMLALLPVLIWL 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 212 LLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGA 291
Cdd:PRK03784 208 CCQGRPLNMLALGEISARQLGLPLWFWRNLLVLATGWLVGVSVALAGAIGFIGLVIPHILRLCGLTDHRVLLPGCALAGA 287

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|
gi 446047327 292 TLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRRR 331
Cdd:PRK03784 288 SLLLLADIVARLALASAELPIGVVTATLGAPVFIWLLLRS 327
fecD PRK09777
Fe(3+) dicitrate ABC transporter permease subunit FecD;
15-330 1.17e-39

Fe(3+) dicitrate ABC transporter permease subunit FecD;


Pssm-ID: 182071  Cd Length: 318  Bit Score: 142.11  E-value: 1.17e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  15 VAALIIIFWLSLFcYSAIPVSGADATRALLPGHTPTLpeaLVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSL 94
Cdd:PRK09777  10 TLALAGCALLSLR-MGVIPLPWRALLTDWQAGDEHYY---VLMEYRLPRLLLALFVGAALAVSGVLVQGIVRNPLASPDI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  95 LGINSGAALAMALTSALSPTpIAGYSLSFIAACGGGVGWLLVMTAGGgfrhTHDRNKLILAGIALSAFCMGLTRITLLLA 174
Cdd:PRK09777  86 LGVNHAASLASVGALLLFPS-LPVMWLPLLAFIGGMAGLILLKMLAG----THQPMKLALTGVALSALWASLTDYLMLSR 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 175 EDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACV 254
Cdd:PRK09777 161 PQDINNALLWLTGSLWGRDWSFVKVALPWLILLLPLSLSFCRDLDLLALGDARATTLGVSVPHTQFWALLLAVALTATGV 240

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446047327 255 SVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLALIGSPCFVWLVRR 330
Cdd:PRK09777 241 AACGPISFIGLVVPHLMRSLVGGRHRRLLPVSALTGALLLLLADLLARIIHPPLELPAGVLTAIIGAPWFFWLLVR 316
PRK10441 PRK10441
Fe(3+)-siderophore ABC transporter permease;
55-332 4.65e-37

Fe(3+)-siderophore ABC transporter permease;


Pssm-ID: 182464  Cd Length: 335  Bit Score: 135.60  E-value: 4.65e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  55 LVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAALAMALTSALSPTPIAGYSLSFiAACGGGVGWL 134
Cdd:PRK10441  55 IVLDARLPRTLAGLLAGGALGLAGALMQTLTRNPLADPGLLGVNAGASFAIVLGAALFGYSSAQEQLAM-AFAGALVASL 133

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 135 LVMTAGGGFRHTHDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLL 214
Cdd:PRK10441 134 IVAFTGSQGGGQLSPVRLTLAGVALAAVLEGLTSGIALLNPDVYDQLRFWQAGSLDIRNLHTLKVVLIPVLIAGATALLL 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 215 ANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSMLLGATLM 294
Cdd:PRK10441 214 SRALNSLSLGSDTATALGSRVARTQLIGLLAITVLCGSATAVVGPIAFIGLMMPHMARWLVGADHRWSLPVTLLATPALL 293

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 446047327 295 LLADVLARALAfPGDLPAGAVLALIGSPCFVWLVRRRG 332
Cdd:PRK10441 294 LFADIIGRLLV-PGELRVSVVSAFIGAPVLIFLVRRKT 330
btuC PRK09535
cobalamin ABC transporter permease BtuC;
49-331 2.02e-36

cobalamin ABC transporter permease BtuC;


Pssm-ID: 236553  Cd Length: 366  Bit Score: 134.49  E-value: 2.02e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  49 PTLPEALVQNLRLPRSLVAVLIGASLALAGTLLQTLTHNPMASPSLLGINSGAAL-AMALTSALSPTPIAGYSLSFIAAC 127
Cdd:PRK09535  84 PETAQTIVLQIRLPRILLAATVGFALAAAGTVMQGFFRNPMADPSIIGVSSGAAVgAVAAIVLPLAVPFGLQAAAFAGAL 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 128 GGGVGWLLVMTAGGgfrHThDRNKLILAGIALSAFCMGLTRITLLLAEDHAYGIFYWLAGGVSHARWQDVWQLLPVVVTA 207
Cdd:PRK09535 164 VAAFGVYAIATENG---RT-PVATLLLAGVAVQTFLGAVISYLLLHSGESLRRAVYWLMGHLHGSTWSDVEVALPVVVVG 239

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 208 VPVVLLLANQLNLLNLSDSTAHTLGVNLTRLRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGFDQRNVLPVSM 287
Cdd:PRK09535 240 FVVLLAYARDLNVLLLGEEDAHTLGIEVERTKRLLLALASVVTAAAVAVAGVIGFVGLIVPHVMRLLVGPDHRILLPTSA 319

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....
gi 446047327 288 LLGATLMLLADVLARalAFPGDLPAGAVLALIGSPCFVWLVRRR 331
Cdd:PRK09535 320 LAGASFLVATDTVAR--SGPAEVPVGIVTAALGAPFFLYLLRTR 361
PRK10440 PRK10440
iron-enterobactin ABC transporter permease;
1-330 1.22e-25

iron-enterobactin ABC transporter permease;


Pssm-ID: 182463  Cd Length: 330  Bit Score: 104.79  E-value: 1.22e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327   1 MTAIKHPVLLWGLPVAALIIIFWLSLfCYSAIPVSGADATRALLpGHTPTLPEALVQNLRLPRSLVAVLIGASLALAGTL 80
Cdd:PRK10440   2 IYVSRRLLITCLLLLAACVAAGLWGL-RSGAVTLETSQVFAALM-GDAPRSMTMVVTEWRLPRVLMALLIGAALGVSGAI 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327  81 LQTLTHNPMASPSLLGINSGAalamaLTSALSPTPIAGYSLSFIA--ACGGGVGWLLVMTAGGgFRHTHDRNKLILAGIA 158
Cdd:PRK10440  80 FQSLMRNPLGSPDVMGFNTGA-----WSGVLVAMVLFGQDLTAIAlaAMAGGIVTSLLVWLLA-WRNGIDTFRLIIIGIG 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 159 LSAFCMGLTRITLLLAE-DHAYGIFYWLAGGVSHARWQDVWQLLPVVVTAVPVVLLLANQLNLLNLSDSTAHTLGVNLTR 237
Cdd:PRK10440 154 VRAMLVAFNTWLLLKASlETALTAGLWNAGSLNGLTWAKTSPSAPIIILMLIAAALLVRRMRLLEMGDDTACALGVSVER 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446047327 238 LRLVINMLVLLLVGACVSVAGPVAFIGLLVPHLARFWAGfDQRNVLPVSMLLGATLMLLADVLARALAFPGDLPAGAVLA 317
Cdd:PRK10440 234 SRLLLMLVAVVLTAAATALAGPISFIALVAPHIARRLSG-TARWGLTQAALCGALLLLAADLCAQQLFMPYQLPVGVVTV 312

                        330
                 ....*....|...
gi 446047327 318 LIGSPCFVWLVRR 330
Cdd:PRK10440 313 SLGGIYLIVLLIQ 325
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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