|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
3-469 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 790.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 3 RRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFK 82
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 83 EGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGI 162
Cdd:PRK05826 81 EGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 163 NKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEAVcsqDAMDDIIL 241
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 242 ASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAET 321
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 322 AAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSG 401
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013306 402 LPIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVG 469
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
4-479 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 731.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 4 RLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKE 83
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 84 GKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGIN 163
Cdd:COG0469 81 GPVELKKGDTFTLTTD--DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 164 KLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcsqDAMDDIILAS 243
Cdd:COG0469 159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 244 DVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 323
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 324 GQYPSETVAAMARVCLGAEKIPSINVSKHRL-DVQFDNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGL 402
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKV 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446013306 403 PIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTV 479
Cdd:COG0469 395 PILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
5-479 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 693.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 5 LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 85 -KVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGM-KVFTEVTVGGPLSNNKGI 162
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 163 NKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSQDamdDIILA 242
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD---EILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 243 SDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETA 322
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 323 AGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFD---NVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRIS 399
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 400 SGLPIFAMSRHERTLNLTALYRGVTPVYFDSA-----SDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMsTVGSTNTT 474
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV-GSGSTNTM 475
|
....*
gi 446013306 475 RILTV 479
Cdd:cd00288 476 RILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
6-476 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 656.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 6 RRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK 85
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 86 VFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKL 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 166 GGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAG-CDAKIVAKVERAEAVCSqdaMDDIILASD 244
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 245 VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 324
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 325 QYPSETVAAMARVCLGAEKIPS-INVSKHRL--DVQFDNVEEAIAMSAMYAANHLKgVTAIITMTESGRTALMTSRISSG 401
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAyLTNFNDRKnsDPKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446013306 402 LPIFAMSRHERTLNLTALYRGVTPVYFDS-ASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRI 476
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
5-350 |
1.93e-163 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 465.69 E-value: 1.93e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 5 LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 85 K--VFLNIGDKFL--LDANLgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK-VFTEVTVGGPLSNN 159
Cdd:pfam00224 81 KkdIELKAGDEMIvsTDAKY-KGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 160 KGINKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcsqDAMDDI 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGV---NNFDEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 240 ILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSA 319
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316
|
330 340 350
....*....|....*....|....*....|..
gi 446013306 320 ETAAGQYPSETVAAMARVCLGAEK-IPSINVS 350
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEKaLPHRNLF 348
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK05826 |
PRK05826 |
pyruvate kinase; Provisional |
3-469 |
0e+00 |
|
pyruvate kinase; Provisional
Pssm-ID: 235619 [Multi-domain] Cd Length: 465 Bit Score: 790.12 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 3 RRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFK 82
Cdd:PRK05826 1 RMLRRTKIVATLGPASDSPENLEKLIEAGVNVVRLNFSHGSHEEHGKRAALVREIAAKLGRPVAILLDLKGPKIRVGKFK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 83 EGKVFLNIGDKFLLDANlGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGI 162
Cdd:PRK05826 81 EGKITLKTGDKFTLDTD-QKEEGDKERVGVDYKGLPKDVKPGDILLLDDGKLQLKVVEVDGDEVETEVKNGGPLSNNKGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 163 NKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEAVcsqDAMDDIIL 241
Cdd:PRK05826 160 NIPGGGLSLPALTEKDKADIKFAAEQGVDYIAVSFVRSAEDVEEARRLLREAGCpHAKIIAKIERAEAV---DNIDEIIE 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 242 ASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAET 321
Cdd:PRK05826 237 ASDGIMVARGDLGVEIPDEEVPGLQKKIIRKAREAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGET 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 322 AAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDNVEEAIAMSAMYAANHLKGVTAIITMTESGRTALMTSRISSG 401
Cdd:PRK05826 317 AAGKYPVEAVEAMARICKGAEKEFSINLSKHRLDRQFDRIDEAIAMSAMYAANHLKGVKAIVALTESGRTARLISRFRPG 396
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013306 402 LPIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVG 469
Cdd:PRK05826 397 APIFAVTRDEKTQRRLALYRGVYPVLFDSAADTDDAAEEALRLLLEKGLVESGDLVVVTSGDPMGTAG 464
|
|
| PykF |
COG0469 |
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the ... |
4-479 |
0e+00 |
|
Pyruvate kinase [Carbohydrate transport and metabolism]; Pyruvate kinase is part of the Pathway/BioSystem: Glycolysis
Pssm-ID: 440237 [Multi-domain] Cd Length: 471 Bit Score: 731.45 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 4 RLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKE 83
Cdd:COG0469 1 MMRRTKIVATLGPASDSPEVLRKLIEAGMDVARLNFSHGDHEEHRERIELIREAAKELGRPVAILLDLQGPKIRTGKFKE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 84 GKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGIN 163
Cdd:COG0469 81 GPVELKKGDTFTLTTD--DVEGDAERVSVTYPELPEDVKPGDRILLDDGKIELRVEEVEGDEVVCEVVNGGVLSSRKGVN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 164 KLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcsqDAMDDIILAS 243
Cdd:COG0469 159 LPGVGLSLPALTEKDREDLKFALELGVDFIALSFVRSAEDVLEARELLEEAGGRAPIIAKIEKPEAV---ENLDEIIEAS 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 244 DVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAA 323
Cdd:COG0469 236 DGIMVARGDLGVEIPLEEVPLIQKRIIRKARRAGKPVITATQMLESMIENPRPTRAEVSDVANAVLDGTDAVMLSGETAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 324 GQYPSETVAAMARVCLGAEKIPSINVSKHRL-DVQFDNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGL 402
Cdd:COG0469 316 GKYPVEAVETMARIAEEAEKSLDYRRILDRLrDEPERTITDAIARAAVELAEDL-GAKAIVAFTESGSTARRISRYRPKV 394
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 446013306 403 PIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTV 479
Cdd:COG0469 395 PILALTPNERTARRLALVWGVYPVLVDDVESTDEMIEEAVEALLEEGLVKPGDLVVITAGVPVGVPGTTNTLKVHRV 471
|
|
| Pyruvate_Kinase |
cd00288 |
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of ... |
5-479 |
0e+00 |
|
Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low affinity T state. PK exists as several different isozymes, depending on organism and tissue type. In mammals, there are four PK isozymes: R, found in red blood cells, L, found in liver, M1, found in skeletal muscle, and M2, found in kidney, adipose tissue, and lung. PK forms a homotetramer, with each subunit containing three domains. The T state to R state transition of PK is more complex than in most allosteric enzymes, involving a concerted rotation of all 3 domains of each monomer in the homotetramer.
Pssm-ID: 238178 [Multi-domain] Cd Length: 480 Bit Score: 693.67 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 5 LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:cd00288 1 LRRTKIVCTIGPATDSVENLKKLIKAGMNVARMNFSHGSHEYHQSRIDNVREAAEKTGGPVAIALDTKGPEIRTGLFKGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 85 -KVFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGM-KVFTEVTVGGPLSNNKGI 162
Cdd:cd00288 81 kDISLKAGDKFLVTTDPAAKKGTKEKIYVDYKNLTKDVSPGNTILVDDGLLSLKVLSKDDDkTLVCEVLNGGVLGSRKGV 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 163 NKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSQDamdDIILA 242
Cdd:cd00288 161 NLPGTDVDLPALSEKDKADLRFGVEQGVDMIFASFVRKASDVLEIREVLGEKGKDIKIIAKIENQEGVNNFD---EILEA 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 243 SDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETA 322
Cdd:cd00288 238 SDGIMVARGDLGVEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSGETA 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 323 AGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFD---NVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRIS 399
Cdd:cd00288 318 KGKYPVEAVKAMARICLEAEKALSHRVLFNEMRRLTPrptSTTEAVAMSAVRAAFEL-GAKAIVVLTTSGRTARLVSKYR 396
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 400 SGLPIFAMSRHERTLNLTALYRGVTPVYFDSA-----SDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMsTVGSTNTT 474
Cdd:cd00288 397 PNAPIIAVTRNEQTARQLHLYRGVYPVLFEEPkpgwqEDTDARLKAAVNVAKEKGLLKKGDLVVVVQGWPV-GSGSTNTM 475
|
....*
gi 446013306 475 RILTV 479
Cdd:cd00288 476 RILTV 480
|
|
| pyruv_kin |
TIGR01064 |
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of ... |
6-476 |
0e+00 |
|
pyruvate kinase; This enzyme is a homotetramer. Some forms are active only in the presence of fructose-1,6-bisphosphate or similar phosphorylated sugars. [Energy metabolism, Glycolysis/gluconeogenesis]
Pssm-ID: 273424 [Multi-domain] Cd Length: 472 Bit Score: 656.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 6 RRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGK 85
Cdd:TIGR01064 1 RRTKIVCTIGPATNSPEMLKKLLDAGMNVARLNFSHGSHEEHGKRIENVREAAEKLGRPVAILLDTKGPEIRTGEIKGGE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 86 VFLNIGDKFLLDANLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKL 165
Cdd:TIGR01064 81 VKLKKGDKVIITTDDIKGEGDEEKVYVDYKGLTKDVVEGDKILVDDGKISLVVVSVEGDKVICEVLNGGTLKSKKGVNLP 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 166 GGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAG-CDAKIVAKVERAEAVCSqdaMDDIILASD 244
Cdd:TIGR01064 161 GADVDLPALSEKDKKDLKFGVEQGVDMVAASFVRTAEDVLEVREVLGEKGaKDVKIIAKIENQEGVDN---IDEIAEASD 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 245 VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 324
Cdd:TIGR01064 238 GIMVARGDLGVEIPAEEVPIAQKKMIRKCNRAGKPVITATQMLDSMIKNPRPTRAEVSDVANAVLDGTDAVMLSGETAKG 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 325 QYPSETVAAMARVCLGAEKIPS-INVSKHRL--DVQFDNVEEAIAMSAMYAANHLKgVTAIITMTESGRTALMTSRISSG 401
Cdd:TIGR01064 318 KYPVEAVQMMAKIAKEAEKALAyLTNFNDRKnsDPKPSTITEAIALSAVEAAEKLD-AKAIVVLTESGRTARLLSKYRPN 396
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 446013306 402 LPIFAMSRHERTLNLTALYRGVTPVYFDS-ASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRI 476
Cdd:TIGR01064 397 APIIAVTPNERVARQLALYWGVFPFLVDEePSDTDARVNKALELLKEKGIVKKGDLVVVIQGGPIGGEGGTNTIRV 472
|
|
| PK |
pfam00224 |
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain ... |
5-350 |
1.93e-163 |
|
Pyruvate kinase, barrel domain; This domain of the is actually a small beta-barrel domain nested within a larger TIM barrel. The active site is found in a cleft between the two domains.
Pssm-ID: 395168 [Multi-domain] Cd Length: 348 Bit Score: 465.69 E-value: 1.93e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 5 LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:pfam00224 1 LRRTKIVCTIGPASNSVENLEKLIEAGANVARMNFSHGSHEYHQSRIDNVREAEEKTGGTVAIALDTKGPEIRTGNTKDG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 85 K--VFLNIGDKFL--LDANLgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK-VFTEVTVGGPLSNN 159
Cdd:pfam00224 81 KkdIELKAGDEMIvsTDAKY-KGACDDEMIYVDYKNIVKDVSVGGTILVDDGLLSLKVLSKDDDKtLVVEVLNGGVIGSR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 160 KGINKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcsqDAMDDI 239
Cdd:pfam00224 160 KGVNLPGTDVDLPALSEKDKADLRFGVKNGVDMIFASFVRKASDVLEIREVLGEAGKNIQIIAKIENQEGV---NNFDEI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 240 ILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSA 319
Cdd:pfam00224 237 LEATDGIMVARGDLGIEIPAEEVFLAQKMLIAKCNLAGKPVITATQMLESMIYNPRPTRAEVSDVANAVLDGTDCVMLSG 316
|
330 340 350
....*....|....*....|....*....|..
gi 446013306 320 ETAAGQYPSETVAAMARVCLGAEK-IPSINVS 350
Cdd:pfam00224 317 ETAKGNYPVEAVRMMHEICLEAEKaLPHRNLF 348
|
|
| PRK06247 |
PRK06247 |
pyruvate kinase; Provisional |
3-479 |
3.43e-151 |
|
pyruvate kinase; Provisional
Pssm-ID: 180487 [Multi-domain] Cd Length: 476 Bit Score: 439.36 E-value: 3.43e-151
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 3 RRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFK 82
Cdd:PRK06247 2 KRNRRVKILATLGPASSSEDMIRKLVEAGADVFRLNFSHGDHDDHRELYKRIREVEDETGRPIGILADLQGPKLRLGRFA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 83 EGKVFLNIGDKFLLDanLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGI 162
Cdd:PRK06247 82 DGKVQLANGQTFRLD--VDDAPGDHDRVSLPHPEIAAALKPGDRLLVDDGKVRLVVEACDGDDVVCRVVEGGPVSDRKGV 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 163 NKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAgcdAKIVAKVERAEAVcsqDAMDDIILA 242
Cdd:PRK06247 160 SLPGTVLSVSALTEKDRADLEFALELGVDWVALSFVQRPEDVEEVRKIIGGR---VPVMAKIEKPQAI---DRLEAIVEA 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 243 SDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETA 322
Cdd:PRK06247 234 SDAIMVARGDLGVEVPLEQVPLIQKRIIRAARRAGKPVVVATQMLESMIENPVPTRAEVSDVATAVLDGADAVMLSAETA 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 323 AGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFD-NVEEAIAMSAMYAANHLKgVTAIITMTESGRTALMTSRISSG 401
Cdd:PRK06247 314 SGKYPVEAVRTMARIIRQVERDPTYPPLIHAQRPQPEaTKRDAISYAARDIAERLD-LAALVAYTSSGDTALRAARERPP 392
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013306 402 LPIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTV 479
Cdd:PRK06247 393 LPILALTPNPETARRLALTWGVHCVVVDDARDTDDMVRRADRIALAEGFYKRGDRVVIVAGVPPGTPGSTNMLRIAYI 470
|
|
| PRK06354 |
PRK06354 |
pyruvate kinase; Provisional |
1-472 |
1.16e-140 |
|
pyruvate kinase; Provisional
Pssm-ID: 235784 [Multi-domain] Cd Length: 590 Bit Score: 416.25 E-value: 1.16e-140
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 1 MSRR--LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRV 78
Cdd:PRK06354 1 MSLRdlMRRTKIVATIGPASESPEKLRQLIEAGATTARLNFSHGDHEEHGARIKNIREASKKLGKTVGILQDLQGPKIRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 79 STFKEGKVFLNIGDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMK--VFTEVTVGGPL 156
Cdd:PRK06354 81 GRFEDGPIELKTGDEFILTSR--EVLGTQEKFSVTYDGLADEVPVGSRILLDDGLIELEVEEVDKADgeLHCKVLVGGVL 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 157 SNNKGINKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRL-ARDAGCDAKIVAKVERAEAVcsqDA 235
Cdd:PRK06354 159 SNKKGVNFPGVSLSLPAITEKDREDLIFGLEQGVDWIALSFVRNPSDVLEIRELiEEHNGKHIPIIAKIEKQEAI---DN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 236 MDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAV 315
Cdd:PRK06354 236 IDAILELCDGLMVARGDLGVEIPAEEVPLLQKRLIKKANRLGKPVITATQMLDSMQRNPRPTRAEASDVANAILDGTDAV 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 316 MLSAETAAGQYPSETVAAMARVCLGAEK-IPSINVSKHRLDvQFDNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALM 394
Cdd:PRK06354 316 MLSNETAAGDYPVEAVQTMATIAVRIEKdLPYRDILSKRPE-FTTTITNAISQAVSHIALQL-DAAAIVTLTKSGATARN 393
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 446013306 395 TSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTN 472
Cdd:PRK06354 394 VSKYRPKTPILAVTPNESVARRLQLVWGVTPLLVLDAPSTDETFDAAINVAQESGLLKQGDLVVITAGTLVGESGSTD 471
|
|
| PRK09206 |
PRK09206 |
pyruvate kinase PykF; |
5-476 |
9.50e-117 |
|
pyruvate kinase PykF;
Pssm-ID: 181699 [Multi-domain] Cd Length: 470 Bit Score: 351.28 E-value: 9.50e-117
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 5 LRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEG 84
Cdd:PRK09206 1 MKKTKIVCTIGPKTESEEMLTKLLDAGMNVMRLNFSHGDYAEHGQRIKNLRNVMSKTGKKAAILLDTKGPEIRTMKLEGG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 85 K-VFLNIGDKFLL--DANLgkgEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKG 161
Cdd:PRK09206 81 NdVSLKAGQTFTFttDKSV---VGNKERVAVTYEGFTADLSVGNTVLVDDGLIGMEVTAITGNEVICKVLNNGDLGENKG 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 162 INKLGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARR-LARDAGCDAKIVAKVERAEAVcsqDAMDDII 240
Cdd:PRK09206 158 VNLPGVSIALPALAEKDKQDLIFGCEQGVDFVAASFIRKRSDVLEIREhLKAHGGENIQIISKIENQEGL---NNFDEIL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 241 LASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAE 320
Cdd:PRK09206 235 EASDGIMVARGDLGVEIPVEEVIFAQKMMIEKCNRARKVVITATQMLDSMIKNPRPTRAEAGDVANAILDGTDAVMLSGE 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 321 TAAGQYPSETVAAMARVClgaEKIPSinVSKHRLDVQFDN----VEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTS 396
Cdd:PRK09206 315 SAKGKYPLEAVSIMATIC---ERTDR--VMNSRLESNNDNrklrITEAVCRGAVETAEKL-DAPLIVVATQGGKSARSVR 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 397 RISSGLPIFAMSRHERTLNLTALYRGVTPVY---FDSASDGVVAASEAVnllRDKGYLMSGDLVIVTQGDVMSTvGSTNT 473
Cdd:PRK09206 389 KYFPDATILALTTNEKTARQLVLSKGVVPQLvkeIASTDDFYRLGKELA---LQSGLAQKGDVVVMVSGALVPS-GTTNT 464
|
...
gi 446013306 474 TRI 476
Cdd:PRK09206 465 ASV 467
|
|
| PTZ00066 |
PTZ00066 |
pyruvate kinase; Provisional |
4-480 |
7.56e-102 |
|
pyruvate kinase; Provisional
Pssm-ID: 173361 [Multi-domain] Cd Length: 513 Bit Score: 314.39 E-value: 7.56e-102
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 4 RLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREiAAKLGRH--VAILGDLQGPKIRVSTF 81
Cdd:PTZ00066 36 RQKKTHIVCTMGPACKNVETLVKLIDAGMNICRFNFSHGDHESHKKTLNNVRE-AAKARPNanLGILLDTKGPEIRTGFL 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 82 KEGK-VFLNIGD--KFLLDANLgkgEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSN 158
Cdd:PTZ00066 115 KNHKpITLKEGQtlKITTDYTF---LGDETCISCSYKKLPQSVKVGNIILIADGSLSCKVLEVHDDYIITKVLNNATIGE 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 159 NKGINKLGGGLSAEALTEKDKADIQTAAL-IGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSqdaMD 237
Cdd:PTZ00066 192 RKNMNLPGVKVELPVIGEKDKNDILNFAIpMGCDFIALSFVQSADDVRLCRQLLGERGRHIKIIPKIENIEGLIN---FD 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 238 DIILASDVVMVARGDLGVEIgDPELVGI-QKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVM 316
Cdd:PTZ00066 269 EILAESDGIMVARGDLGMEI-PPEKVFLaQKMMISKCNVAGKPVITATQMLESMIKNPRPTRAESTDVANAVLDGTDCVM 347
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 317 LSAETAAGQYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFD---NVEEAIAMSAMYAANHLkGVTAIITMTESGRTAL 393
Cdd:PTZ00066 348 LSGETANGKFPVEAVNIMAKICFEAETCIDYRVLYHAIHLAVPtpvSVQEAVARSAVETAEDI-NAKLIIALTETGNTAR 426
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 394 MTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNT 473
Cdd:PTZ00066 427 LISKYRPSCTILALSASPSVVKSLSVARGVTTYVVNSFQGTDVVIRNAIALAKERGLVESGDSAIAVHGVKEEVAGSSNL 506
|
....*..
gi 446013306 474 TRILTVE 480
Cdd:PTZ00066 507 MKVVKIP 513
|
|
| PLN02461 |
PLN02461 |
Probable pyruvate kinase |
2-480 |
1.64e-95 |
|
Probable pyruvate kinase
Pssm-ID: 215255 [Multi-domain] Cd Length: 511 Bit Score: 297.66 E-value: 1.64e-95
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 2 SRRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTF 81
Cdd:PLN02461 17 GLRRPKTKIVCTLGPASRSVPMLEKLLRAGMNVARFNFSHGSHEYHQETLDNLRQAMANTGILCAVMLDTKGPEIRTGFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 82 KEGK-VFLNIGDKFLL--DANLgkgEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLE--VQGMKVFTEVTVGGPL 156
Cdd:PLN02461 97 KDGKpVQLKQGQEITIttDYSI---KGDENMIAMSYKKLAVDVKPGSVILCADGTITLTVLScdVEAGTVRCRCENSAML 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 157 SNNKGINKLGGGLSAEALTEKDKADI-QTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSqda 235
Cdd:PLN02461 174 GERKNVNLPGVVVDLPTLTEKDKEDIlQWGVPNKIDFIALSFVRKGSDLVEVRKVLGEHAKSILLISKVENQEGLDN--- 250
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 236 MDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAV 315
Cdd:PLN02461 251 FDDILAESDAFMVARGDLGMEIPIEKIFLAQKMMIYKCNLAGKPVVTATQMLESMIKSPRPTRAEATDVANAVLDGTDCV 330
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 316 MLSAETAAGQYPSETVAAMARVCLGAEK-IPSINVSKHRLDVQFD--NVEEAIAMSAMYAANHLKGvTAIITMTESGRTA 392
Cdd:PLN02461 331 MLSGETAAGAYPELAVKTMARICREAEAsLDYGALFKEIMRSAPLpmSPLESLASSAVRTANKVKA-SLIVVLTRGGTTA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 393 LMTSRISSGLPIFAMSRHERTLNLTA-------------LYRGVTPVYFDSASDGVVAAS------EAVNLLRDKGYLMS 453
Cdd:PLN02461 410 RLVAKYRPAVPILSVVVPEITTDSFDwscsdeaparhslIYRGLIPVLAEGSAKATDSESteeileAAIEHAKKKGLCKP 489
|
490 500
....*....|....*....|....*..
gi 446013306 454 GDLVIvtqgdVMSTVGSTNTTRILTVE 480
Cdd:PLN02461 490 GDSVV-----ALHRIGGASVIKILTVK 511
|
|
| PTZ00300 |
PTZ00300 |
pyruvate kinase; Provisional |
33-480 |
1.96e-94 |
|
pyruvate kinase; Provisional
Pssm-ID: 140321 [Multi-domain] Cd Length: 454 Bit Score: 293.11 E-value: 1.96e-94
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 33 NVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVFLNIGDKFLLDANLG-KGEGDKEKVG 111
Cdd:PTZ00300 2 SVARMNFSHGSHEYHQTTINNVRQAAAELGVNIAIALDTKGPEIRTGLFVGGEAVMERGATCYVTTDPAfADKGTKDKFY 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 112 IDYKGLPADVVPGDILLLDDGRVQLKVL---EVQGMKVFteVTVGGPLSNNKGINKLGGGLSAEALTEKDKADIQTAALI 188
Cdd:PTZ00300 82 IDYQNLSKVVRPGGYIYIDDGILILHVQsheDEQTLKCT--VTNAHTISDRRGVNLPGCDVDLPAVSAKDCADLQFGVEQ 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 189 GVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVcsqDAMDDIILASDVVMVARGDLGVEIGDPELVGIQKA 268
Cdd:PTZ00300 160 GVDMIFASFIRSAEQVGEVRKALGAKGGDIMIICKIENHQGV---QNIDSIIEESDGIMVARGDLGVEIPAEKVVVAQKI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 269 LIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKIPSIN 348
Cdd:PTZ00300 237 LISKCNVAGKPVICATQMLESMTYNPRPTRAEVSDVANAVFNGADCVMLSGETAKGKYPNEVVQYMARICLEAQSAVNEY 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 349 V---SKHRLDVQFDNVEEAIAMSAMYAANHLKGvTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTP 425
Cdd:PTZ00300 317 VffnSIKKLQPIPMSAEEAVCSSAVNSVYETKA-KALVVLSNTGRSARLVAKYRPNCPIVCVTTRLQTCRQLNITQGVES 395
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 426 VYFDSASDGVVAASE-----AVNLLRDKGYLMSGDLVIVTQGDvMSTVGSTNTTRILTVE 480
Cdd:PTZ00300 396 VFFDAERLGHDEGKEqrvamGVGFAKSKGYVQSGDLMVVVHAD-HKVKGYANQTRIILVS 454
|
|
| PLN02623 |
PLN02623 |
pyruvate kinase |
6-461 |
4.93e-85 |
|
pyruvate kinase
Pssm-ID: 215334 [Multi-domain] Cd Length: 581 Bit Score: 272.57 E-value: 4.93e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 6 RRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHV-AILGDLQGPKIRVSTFKEg 84
Cdd:PLN02623 110 RKTKIVCTIGPSTNTREMIWKLAEAGMNVARLNMSHGDHASHQKVIDLVKEYNAQSKDNViAIMLDTKGPEVRSGDLPQ- 188
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 85 KVFLNIGDKFLLdaNLGKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINK 164
Cdd:PLN02623 189 PIMLEEGQEFTF--TIKRGVSTEDCVSVNYDDFVNDVEVGDMLLVDGGMMSLAVKSKTSDSVKCEVVDGGELKSRRHLNV 266
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 165 LGGGLSAEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDAKIVAKVERAEAVCSqdaMDDIILASD 244
Cdd:PLN02623 267 RGKSATLPSITEKDWEDIKFGVENKVDFYAVSFVKDAQVVHELKDYLKSCNADIHVIVKIESADSIPN---LHSIITASD 343
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 245 VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAG 324
Cdd:PLN02623 344 GAMVARGDLGAELPIEEVPLLQEEIIRRCRSMGKPVIVATNMLESMIVHPTPTRAEVSDIAIAVREGADAVMLSGETAHG 423
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 325 QYPSETVAAMARVCLGAEKIPSINVSKHRLDVQFDN-VEEAIAMSAMYAANHLKgvTAIITMTESGRTALMTSRISSGLP 403
Cdd:PLN02623 424 KFPLKAVKVMHTVALRTEATLPEGTTPPNLGQAFKNhMSEMFAFHATMMANTLG--TSIIVFTRTGFMAILLSHYRPSGT 501
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 446013306 404 IFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSGDLVIVTQ 461
Cdd:PLN02623 502 IFAFTNEKRIQQRLALYQGVCPIYMQFSDDAEETFARALSLLLNKGMVKEGEEVALVQ 559
|
|
| PRK06739 |
PRK06739 |
pyruvate kinase; Validated |
11-344 |
5.58e-83 |
|
pyruvate kinase; Validated
Pssm-ID: 180676 [Multi-domain] Cd Length: 352 Bit Score: 260.26 E-value: 5.58e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 11 VTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREiaakLGRHVAILGDLQGPKIRVSTFKEGKVFLNI 90
Cdd:PRK06739 6 ICTIGPASNNKETLAQLINNGMKIVRLNLSHGTHESHKDIIRLVKS----LDDSIKILGDVQGPKIRLGEIKGEQITLQA 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 91 GDKFLLDANlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGPLSNNKGINKLGGGLS 170
Cdd:PRK06739 82 GDSFILHTQ--PVTGSSTEASVDYEGIANDVKVGSRILMNDGEVELIVEKVSTDKIETKVKTGGNISSHKGVNLPGAIVR 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 171 AEALTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRLARDAGCDA-KIVAKVERAEAVcsqDAMDDIILASDVVMVA 249
Cdd:PRK06739 160 LPAITEKDKKDIQFLLEEDVDFIACSFVRKPSHIKEIRDFIQQYKETSpNLIAKIETMEAI---ENFQDICKEADGIMIA 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 250 RGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSE 329
Cdd:PRK06739 237 RGDLGVELPYQFIPLLQKMMIQECNRTNTYVITATQMLQSMVDHSIPTRAEVTDVFQAVLDGTNAVMLSAESASGEHPIE 316
|
330
....*....|....*
gi 446013306 330 TVAAMARVCLGAEKI 344
Cdd:PRK06739 317 SVSTLRLVSEFAEHV 331
|
|
| PLN02762 |
PLN02762 |
pyruvate kinase complex alpha subunit |
3-459 |
8.28e-78 |
|
pyruvate kinase complex alpha subunit
Pssm-ID: 215407 [Multi-domain] Cd Length: 509 Bit Score: 251.97 E-value: 8.28e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 3 RRLRRTKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTF- 81
Cdd:PLN02762 22 RSTRRTKLVCTIGPACCGFEQLEALAMGGMNVARLNMCHGTREWHRDVIRRVRRLNEEKGFAVAVMMDTEGSEIHMGDLg 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 82 -------KEGKVFLNIGDKFlldanlgKGEGDKEKVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGG 154
Cdd:PLN02762 102 gassakaEDGEEWTFTVRKF-------DGSRPEFTIQVNYDGFAEDVKVGDELVVDGGMVRFEVIEKIGPDVKCKCTDPG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 155 PL---------SNNKGINKLGGGLSAeaLTEKDKADIQTAALIGVDYLAVSFPRCGEDLNYARRL--ARDAGCDAKIVAK 223
Cdd:PLN02762 175 LLlpranltfwRDGSLVRERNAMLPT--ISSKDWLDIDFGISEGVDFIAVSFVKSAEVIKHLKSYiaARSRDSDIGVIAK 252
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 224 VERAEavcSQDAMDDIILASDVVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVMD 303
Cdd:PLN02762 253 IESLD---SLKNLEEIIRASDGAMVARGDLGAQIPLEQVPSVQEKIVRLCRQLNKPVIVASQLLESMIEYPTPTRAEVAD 329
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 304 VANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCL-----GAEKIPSINVSKHRLDVQF-DNVEEAIAMSAMYAANHLk 377
Cdd:PLN02762 330 VSEAVRQRADALMLSGESAMGLYPEKALSVLRSVSLrmelwSREEKRHEALELPQLSSSLsDRISEEICNSAAKMANNL- 408
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 378 GVTAIITMTESGRTALMTSRISSGLPIFAMSRH---ERTLNltaLYRGVTPVYFDSASDGVVAASEAVNLLRDKGYLMSG 454
Cdd:PLN02762 409 GVDAIFVYTKHGHMASLLSRNRPDCPIFAFTDTtsvRRRLN---LQWGLIPFRLDFSDDMESNLNKTFSLLKARGMIKSG 485
|
....*
gi 446013306 455 DLVIV 459
Cdd:PLN02762 486 DLVIA 490
|
|
| PLN02765 |
PLN02765 |
pyruvate kinase |
8-480 |
1.06e-63 |
|
pyruvate kinase
Pssm-ID: 215409 [Multi-domain] Cd Length: 526 Bit Score: 215.30 E-value: 1.06e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 8 TKIVTTLGPATDRDNNLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVSTFKEGKVF 87
Cdd:PLN02765 30 TKIVGTLGPKSRSVEVIEACLKAGMSVARFDFSWGDAEYHQETLENLKIAVKNTKKLCAVMLDTVGPELQVINKTEKPIS 109
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 88 LNIGDKFLLDANLGKgEGDKEKVGIDYKGLPADVVPGDILLL--------DDGRVQLKVLEVQGMKVFTEV----TVGGP 155
Cdd:PLN02765 110 LKAGNTVTLTPDQSK-EASSEVLPINFPGLAKAVKPGDTIFVgqylftgsETTSVWLEVDEVKGDDVVCTVknsaTLAGS 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 156 L----SNNKGInklggglSAEALTEKDKADIQT-AALIGVDYLAVSFPRCGEDLNYARRLARDAGC-DAKIVAKVERAEA 229
Cdd:PLN02765 189 LftlhVSQVRI-------DLPTLSEKDKEVISTwGVPNKIDFLSLSYTRHAEDVREAREFLSSLGLsQTQIFAKIENVEG 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 230 VcsqDAMDDIILASDVVMVARGDLGVEIgDPELVGI-QKALIRRARQLNRAVITaTQMMESMITNPMPTRAEVMDVANAV 308
Cdd:PLN02765 262 L---THFDEILQEADGIILSRGNLGIDL-PPEKVFLfQKAALYKCNMAGKPAVV-TRVVDSMTDNLRPTRAEATDVANAV 336
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 309 LDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEKipsinVSKHrlDVQFDNV----------EEAIAMSAMYAANHLKG 378
Cdd:PLN02765 337 LDGADAILLGAETLRGLYPVETISTVGRICAEAEK-----VFNQ--DLYFKKTvkyvgepmshLESIASSAVRAAIKVKA 409
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 379 vTAIITMTESGRTALMTSRISSGLPIFAM---------SRHERTLNLTA----LYRGVTPVYFDS--ASDGVVAASE--- 440
Cdd:PLN02765 410 -SVIIVFTSSGRAARLIAKYRPTMPVLSVviprlktnqLKWSFTGAFQArqclIVRGLFPMLADPrhSAESTSATNEsvl 488
|
490 500 510 520
....*....|....*....|....*....|....*....|..
gi 446013306 441 --AVNLLRDKGYLMSGDLVIVTQgdvmsTVGSTNTTRILTVE 480
Cdd:PLN02765 489 kvALDHGKAAGVIKSHDRVVVCQ-----KVGDSSVVKIIELD 525
|
|
| PK_C |
pfam02887 |
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is ... |
363-477 |
3.88e-39 |
|
Pyruvate kinase, alpha/beta domain; As well as being found in pyruvate kinase this family is found as an isolated domain in some bacterial proteins.
Pssm-ID: 460738 [Multi-domain] Cd Length: 114 Bit Score: 137.61 E-value: 3.88e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 363 EAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSASDGVVAASEAV 442
Cdd:pfam02887 1 EAIAHAAVEAAEEL-GAKAIVVLTESGYTARLISRYRPGVPIIAVTPNELTARQLALYWGVYPVLFDEAETTDEMLRRAV 79
|
90 100 110
....*....|....*....|....*....|....*
gi 446013306 443 NLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRIL 477
Cdd:pfam02887 80 KVAKEAGLVKKGDLVVITAGVPFGVSGTTNTLKVI 114
|
|
| PykA2 |
COG3848 |
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms]; |
280-479 |
2.16e-37 |
|
Phosphohistidine swiveling domain of PEP-utilizing enzymes [Signal transduction mechanisms];
Pssm-ID: 443058 Cd Length: 321 Bit Score: 139.26 E-value: 2.16e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 280 VITATQMMESMITNPMPTRAEVMDVANAVLDGTDAVMLSAETAAGQYPSETVAAMARVCLGAEK-------IPSINVSKH 352
Cdd:COG3848 9 VITATQMLDSMMRNPRPTRAEAADVANAIFDGTDAIMLSGETAAGKYPVEAVVTMVRIAERAEEdleyreqRVPRAKESS 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 353 RldvqfdNVEEAIAMSAMYAANHLkGVTAIITMTESGRTALMTSRISSGLPIFAMSRHERTLNLTALYRGVTPVYFDSAS 432
Cdd:COG3848 89 T------TITDAISHAVATTAADL-GAAAIITATESGATARMVSKYRPKAPIIAVTPSERVARQLSLVWGVYPLLVEESA 161
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 446013306 433 DGVVAASEAVNLLRDKGYLMSGDLVIVTQGDVMSTVGSTNTTRILTV 479
Cdd:COG3848 162 STDEMFAVAVALALEAGLVKDGDLVVITAGVPVGVSGTTNLLKVHVV 208
|
|
| PRK08187 |
PRK08187 |
pyruvate kinase; Validated |
3-337 |
7.88e-36 |
|
pyruvate kinase; Validated
Pssm-ID: 236178 Cd Length: 493 Bit Score: 138.99 E-value: 7.88e-36
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 3 RRLRRTKIVTTLGP--ATDRDNNLEkVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVST 80
Cdd:PRK08187 130 PAARRTRIMVTLPSeaADDPDFVLR-LAERGMDCARINCAHDDPAAWQAMIGHLRQAERATGRRCKILMDLAGPKIRTGA 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 81 F--KEGKVFLNIGDKFLLDANLGKGEGDKE--KVGIDYKGLPADVVPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGP- 155
Cdd:PRK08187 209 VagPLGKTRLYTGDRLALVAQGPPRRIDEEhfQVTCTLPEILARLAVGARVWIDDGKLGARVERVGPGGALLEVTHARPk 288
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 156 ---LSNNKGINKLGGGLSAEALTEKDKADIQTAALiGVDYLAVSFPRCGEDLN-----YARRLARDAGcDAKIVAKVERA 227
Cdd:PRK08187 289 glkLKPEKGLNFPDTALDLPALTEKDRADLDFVAR-HADLVGYSFVQSPGDVEalqaaLAARRPDDWR-KLGLVLKIETP 366
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 228 EAVcsqDAMDDIILASD-----VVMVARGDLGVEIGDPELVGIQKALIRRARQLNRAVITATQMMESMITNPMPTRAEVM 302
Cdd:PRK08187 367 RAV---ANLPELIVQAAgrqpfGVMIARGDLAVEIGFERLAEMQEEILWLCEAAHVPVIWATQVLEGLVKKGLPSRAEMT 443
|
330 340 350
....*....|....*....|....*....|....*
gi 446013306 303 DVANAvlDGTDAVMLSaetaAGQYPSETVAAMARV 337
Cdd:PRK08187 444 DAAMA--ARAECVMLN----KGPYLVEAVTFLDDL 472
|
|
| PRK14725 |
PRK14725 |
pyruvate kinase; Provisional |
6-317 |
1.08e-23 |
|
pyruvate kinase; Provisional
Pssm-ID: 237804 Cd Length: 608 Bit Score: 104.26 E-value: 1.08e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 6 RRTKIVTTLgP---ATDRDNnLEKVIAAGANVVRMNFSHGSPEDHKMRADKVREIAAKLGRHVAILGDLQGPKIRVST-- 80
Cdd:PRK14725 139 RPTRIMVTL-PteaADDPDL-VRRLLAAGMDIARINCAHDDPEAWRAMIANVRTAEEELGRRCRIAMDLAGPKLRTGPia 216
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 --------------------------------------------------------------------------------
Cdd:PRK14725 217 pgprviklrptrdalgrvltparlwltasespppspppgpvglpvdpewlarlepgdelrftdargkkrkltvtevddeg 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 81 -------------------------------FKEGKVFLNIGDKFLL--DANLG---KGEGDKEKVGIdykGLPA---DV 121
Cdd:PRK14725 297 vlaegsqtaylangtllrlgrhdstrvgglpPVEQKLRLKVGDRLVLtrDDAPGdpaQGDAPPARISC---TLPEafrAA 373
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 122 VPGDILLLDDGRVQLKVLEVQGMKVFTEVTVGGP----LSNNKGINKLGGGLSAEALTEKDKADIQTAALIGvDYLAVSF 197
Cdd:PRK14725 374 RVGERVWFDDGKIGAVVVKVEADEVELRITHARPggskLKAGKGINLPDSHLPLPALTDKDLEDLAFVAKHA-DIVALSF 452
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 446013306 198 PRCGEDLNY-----ARRLARDAGcdakIVAKVERAEAVcsqDAMDDIILAS----DV-VMVARGDLGVEIGDPELVGIQK 267
Cdd:PRK14725 453 VRSPEDVRLlldalEKLGADDLG----VVLKIETRRAF---ENLPRILLEAmrhpRFgVMIARGDLAVEVGFERLAEVQE 525
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|
gi 446013306 268 ALIRRARQLNRAVITATQMMESMITNPMPTRAEVMDVANAVLdgTDAVML 317
Cdd:PRK14725 526 EILWLCEAAHVPVIWATQVLESLAKKGLPSRAEITDAAMALR--AECVML 573
|
|
| |
