|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1205.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 2 SKKEFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDPEASE 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 82 NDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 162 SNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAEST 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 242 LKTVKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 322 RNIKAKINREGIWIEKLEHNPGQYIPPALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 402 ERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 445959348 482 LGSIGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
2.93e-130 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 377.97 E-value: 2.93e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 332 GIWIEKLEHNPGQYIPPALRQAGEgDAVKVDLNRPmkEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKERIESGEDLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 412 QYIKD--HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 445959348 490 AVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
42-341 |
4.08e-128 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 375.95 E-value: 4.08e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 42 VEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDpEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRV 121
Cdd:COG1951 4 IDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQDV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 122 WTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDmykEVNTGSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYqetka 201
Cdd:COG1951 83 PIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 202 LLTPGK----LKNFLVEKMRTLGTAACPPYHIAFVIGGTsAESTLKTVKLASTHYYDALPTEgnehgqaFRDLRLEQELL 277
Cdd:COG1951 155 MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEELL 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445959348 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWieKLEHN 341
Cdd:COG1951 227 EAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
3.40e-83 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 256.21 E-value: 3.40e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 372 AQLSQYPVSTRLSLTGTIIVGRDIAHAKLKERIESGEDLPQYIKDHPIYYAGPAKTPAGYP-SGSLGPTTAGRMDSYVDL 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 451 LQSHGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQQsIKHLECVEYPELGM-EAIWKIEVEDF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQS-VKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 445959348 529 DKGNDFFQQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK15389 |
PRK15389 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 237955 [Multi-domain] Cd Length: 536 Bit Score: 1205.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 2 SKKEFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDPEASE 81
Cdd:PRK15389 1 SMPPFKYQDLFPLGKDDTEYRLLTSDGVSVAEFEGREILKVEPEALTLLAEEAFHDISHLLRPAHLQQLAKILDDPEASD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 82 NDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMYKEVNTG 161
Cdd:PRK15389 81 NDKFVALDLLKNANIAAGGVLPMCQDTGTAIIMGKKGQRVWTGGDDEEALSRGVYDTYTELNLRYSQNAPLDMYEEKNTG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 162 SNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAEST 241
Cdd:PRK15389 161 TNLPAQIDIYATEGDEYKFLFMAKGGGSANKTFLYQETKALLNPDRLLAFLVEKMRTLGTAACPPYHLAIVIGGTSAEAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 242 LKTVKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSAD 321
Cdd:PRK15389 241 LKTVKLASAKYLDALPTEGNEHGHAFRDLELEQEVLKLTQKLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSAD 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 322 RNIKAKINREGIWIEKLEHNPGQYIPPALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLK 401
Cdd:PRK15389 321 RNIKAKITRDGIFLEQLETNPARYLPEVLREKLEGEVVKIDLNRPMAEILAELSKYPVKTRLSLTGTIIVARDIAHAKLK 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 402 ERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGFY 481
Cdd:PRK15389 401 ERLDAGEGLPQYLKDHPVYYAGPAKTPEGYASGSFGPTTAGRMDSYVDLFQAAGGSMVMLAKGNRSQQVTDACKKHGGFY 480
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|....*.
gi 445959348 482 LGSIGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PRK15389 481 LGSIGGPAARLAQDCIKKVEVLEYPELGMEAVWKIEVEDFPAFILVDDKGNDFFKE 536
|
|
| PRK15391 |
PRK15391 |
class I fumarate hydratase; |
1-548 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185289 [Multi-domain] Cd Length: 548 Bit Score: 1204.47 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 1 MSKKEFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDPEAS 80
Cdd:PRK15391 1 MSNKPFIYQAPFPMGKDNTEYYLLTSDYVSVADFDGETILKVEPEALTLLAQQAFHDASFMLRPAHQKQVAAILHDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMYKEVNT 160
Cdd:PRK15391 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEEALSKGVYNTYIEDNLRYSQNAALDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 161 GSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAES 240
Cdd:PRK15391 161 GTNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 241 TLKTVKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15391 241 NLKTVKLASAHYYDELPTEGNEHGQAFRDVQLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 321 DRNIKAKINREGIWIEKLEHNPGQYIPPALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
Cdd:PRK15391 321 DRNIKAKINREGIWIEKLEHNPGQYIPQELRQAGEGEAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 401 KERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGF 480
Cdd:PRK15391 401 KELIDAGKELPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACHKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445959348 481 YLGSIGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVSKQCANCAK 548
Cdd:PRK15391 481 YLGSIGGPAAVLAQQSIKHLECVAYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVNKQCANCTK 548
|
|
| PRK15390 |
PRK15390 |
fumarate hydratase FumA; Provisional |
1-548 |
0e+00 |
|
fumarate hydratase FumA; Provisional
Pssm-ID: 185288 [Multi-domain] Cd Length: 548 Bit Score: 1070.82 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 1 MSKKEFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDPEAS 80
Cdd:PRK15390 1 MSNKPFHYQAPFPLKKDDTEYYLLTSEHVSVSEFEGQEILKVAPEALTLLARQAFHDASFMLRPAHQQQVADILRDPEAS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMYKEVNT 160
Cdd:PRK15390 81 ENDKYVALQFLRNSDIAAKGVLPTCQDTGTAIIVGKKGQRVWTGGGDEAALARGVYNTYIEDNLRYSQNAPLDMYKEVNT 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 161 GSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAES 240
Cdd:PRK15390 161 GTNLPAQIDLYAVDGDEYKFLCIAKGGGSANKTYLYQETKALLTPGKLKNYLVEKMRTLGTAACPPYHIAFVIGGTSAET 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 241 TLKTVKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15390 241 NLKTVKLASAKYYDELPTEGNEHGQAFRDVELEKELLIEAQNLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 321 DRNIKAKINREGIWIEKLEHNPGQYIPPALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
Cdd:PRK15390 321 DRNIKAKINRQGIWIEKLEHNPGKYIPEELRKAGEGEAVRVDLNRPMKEILAQLSQYPVSTRLSLNGTIIVGRDIAHAKL 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 401 KERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGF 480
Cdd:PRK15390 401 KERMDNGEGLPQYIKDHPIYYAGPAKTPEGYASGSLGPTTAGRMDSYVDQLQAQGGSMIMLAKGNRSQQVTDACKKHGGF 480
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445959348 481 YLGSIGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIVSKQCANCAK 548
Cdd:PRK15390 481 YLGSIGGPAAVLAQGSIKSLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQIQLTQCTRCVK 548
|
|
| PTZ00226 |
PTZ00226 |
fumarate hydratase; Provisional |
2-537 |
0e+00 |
|
fumarate hydratase; Provisional
Pssm-ID: 240319 [Multi-domain] Cd Length: 570 Bit Score: 987.23 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 2 SKKEFIYQAPFPMGE--DKTEYYLLT--SDYVSVSEFNGES--ILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILH 75
Cdd:PTZ00226 25 VNPEFNFVPIFQPVDphDTEEYRRLEdlSDYVEVVEVGGGGkeILKVPPEALTKLTSYAFSDIQHFLRKSHLAQLRRILD 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 76 DPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMY 155
Cdd:PTZ00226 105 DPEASDNDRFVAMTLLKNACIAAGRVLPGCQDTGTAIVLGKRGELIWTGGEDEKALSKGVYNAYTNRNLRYSQLAPLDMF 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 156 KEVNTGSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGG 235
Cdd:PTZ00226 185 DEKNTGCNLPAQIDLYATPGNEYEFLFIAKGGGSANKTFLYQQTKSLLNPKSLRKFLEEKIKTIGTSACPPYHLAVVIGG 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 236 TSAESTLKTVKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMG 315
Cdd:PTZ00226 265 LSAEMTLKTVKLASCRYYDSLPTSGDEYGRAFRDLEWEEIILEKTQNIGIGAQFGGKYFAHDVRVIRLPRHGASCPIGIG 344
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 316 VSCSADRNIKAKINREGIWIEKLEHNPGQYIPP-ALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRD 394
Cdd:PTZ00226 345 VSCSADRQILAKINKDGVYLEQLEHDPAQYLPDiTEDDLSKTPVVKIDLNQPMEEILKQLSKYPVKTRLSLTGTLIVARD 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 395 IAHAKLKERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDAC 474
Cdd:PTZ00226 425 IAHAKIVEMLENGEPLPEYMKNHPIYYAGPAKTPDGYASGSFGPTTAGRMDSYVDLFMENGGSFITLAKGNRSKAVTNAC 504
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445959348 475 KKHGGFYLGSIGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PTZ00226 505 KKYGGFYLGSIGGPAAILAKDNIKKVEVLDFPELGMEAVWKIEVENFPAFIVVDDKGNDFYSQ 567
|
|
| PLN00133 |
PLN00133 |
class I-fumerate hydratase; Provisional |
6-537 |
0e+00 |
|
class I-fumerate hydratase; Provisional
Pssm-ID: 215068 [Multi-domain] Cd Length: 576 Bit Score: 908.49 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 6 FIYQAPFPMGEDKT-EYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDPEASENDK 84
Cdd:PLN00133 41 FDYQPLFDSNAKKTvPWRKLTGDHVSVVEAAGEKYLKVAPEALTLLSDTAMRDVAHLLRPGHLQQLRNILDDPEASDNDR 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 85 YVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMYKEVNTGSNL 164
Cdd:PLN00133 121 FVALELLKNANIAAGRVLPGCQDTGTAIVMGKRGQRVLTDGEDEEHLSRGVYDAYTDTNLRYSQVAPLDMFEEKNTGTNL 200
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 165 PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAESTLKT 244
Cdd:PLN00133 201 PAQIDLYAAKGDEYHFQFIAKGGGSANKTFLYQQTKALLNEGSLEAFLEEKIKTIGTSACPPYHLAIVIGGLSAEQNLKT 280
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 245 VKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNI 324
Cdd:PLN00133 281 VKLASTRYYDTLPTSGNALGRAFRDLEWEEKILKMTRGLGIGAQFGGKYFCHDVRVIRLPRHGASCPVGIGVSCSADRQA 360
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 325 KAKINREGIWIEKLEHNPGQYIPPALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKERI 404
Cdd:PLN00133 361 LGKITKDGVFLEALETDPSKYLPDVTEDSLSDDVVKVDLNRPMSEIRETLSAHPVRTRLSLTGTLVVARDIAHAKLLERL 440
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 405 ESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGFYLGS 484
Cdd:PLN00133 441 EAGEGLPQYAKDHIIYYAGPAKTPEGYASGSFGPTTAGRMDSYVDRFMAAGGSFVTLAKGNRSAQVTNACKKHGGFYLGS 520
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|...
gi 445959348 485 IGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:PLN00133 521 IGGPAAILAQNCIKKVEVLENPELGMEAVWKIEVEDFPAFIVVDDKGNDFFKK 573
|
|
| PRK15392 |
PRK15392 |
class I fumarate hydratase; |
1-546 |
0e+00 |
|
class I fumarate hydratase;
Pssm-ID: 185290 [Multi-domain] Cd Length: 550 Bit Score: 884.35 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 1 MSKKeFIYQAPFPMGEDKTEYYLLTSDYVSVSEFNGESILNVEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDPEAS 80
Cdd:PRK15392 1 MSKP-FIWQEPFLQNKDGTEYTLISDQHITVTELDGEEVIKIAPEALTLLARQAFYEASFFLRSAHLQQVASILNDPQAS 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 81 ENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDMYKEVNT 160
Cdd:PRK15392 80 SNDKYVALQLLRNAEVSAKGVLPNCQDTGTATIVASKGQQIWTGGNDAEALSKGIYSTFQENNLRFSQNAPLDMYTEVNT 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 161 GSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYQETKALLTPGKLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAES 240
Cdd:PRK15392 160 QTNLPAQIDISAVAGDEYHFLCVNKGGGSANKAALYQETKSLLQPEKLTAFLIEKMKSLGTAACPPYHIAFVVGGLSADQ 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 241 TLKTVKLASTHYYDALPTEGNEHGQAFRDLRLEQELLEEAQKLGLGAQFGGKYFAHDIRVIRLPRHGASCPVGMGVSCSA 320
Cdd:PRK15392 240 TLKVAKLASTKYYDNLPTSGNEQGQAFRDIELEKVLLEASQQFGIGAQFGGKYFAHDIRVIRLPRHGGSCPIAMALSCSA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 321 DRNIKAKINREGIWIEKLEHNPGQYIPPALRQAGEGDAVKVDLNRPMKEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKL 400
Cdd:PRK15392 320 DRNIKAKINKHGIWLEKLEHNPGQYIPASLREENHAQHVQLDLNRPLRDVMQDLARLPVGTRVSLSGPIVVARDIAHAKI 399
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 401 KERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGF 480
Cdd:PRK15392 400 KARLDSGEPMPEYLKHHIVYYAGPAKTPENMACGSLGPTTGGRMDGYVDTFQAAGGSLVMLSKGNRSQQVTDACHKHGGF 479
|
490 500 510 520 530 540
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 445959348 481 YLGSIGGPAAVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQI-VSKQCANC 546
Cdd:PRK15392 480 NLGSIGGAAALLAQEYVKSLRCLEYPELGMEAVWMMEVENLPAFILVDDKGNNFFSQFeQQHRCASC 546
|
|
| Fumerase_C |
pfam05683 |
Fumarase C-terminus; This family consists of the C terminal region of several bacterial ... |
332-537 |
2.93e-130 |
|
Fumarase C-terminus; This family consists of the C terminal region of several bacterial fumarate hydratase proteins (FumA and FumB). Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth.
Pssm-ID: 461714 [Multi-domain] Cd Length: 204 Bit Score: 377.97 E-value: 2.93e-130
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 332 GIWIEKLEHNPGQYIPPALRQAGEgDAVKVDLNRPmkEILAQLSQYPVSTRLSLTGTIIVGRDIAHAKLKERIESGEDLP 411
Cdd:pfam05683 1 GSGPEQLEPPPLEYWPEWEEDDLA-EAVRVDLNRP--ETREELSKWPVGTRLLLSGTLLTGRDAAHKRIKEMLDKGEPLP 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 412 QYIKD--HPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGpA 489
Cdd:pfam05683 78 EYVDLngRPIYYAGPVDTPGGEVVGSAGPTTATRMDKYVDDFLEKGGSMGMIGKGNRGPAVTEACKKHGGFYLGAIGG-A 156
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 445959348 490 AVLAQQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQQ 537
Cdd:pfam05683 157 AYLAAKAIKKVEVVAFEELGMEAIWEFEVEDFPAFVAVDDKGNSFHKT 204
|
|
| TtdA |
COG1951 |
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy ... |
42-341 |
4.08e-128 |
|
Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441554 Cd Length: 289 Bit Score: 375.95 E-value: 4.08e-128
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 42 VEPQALTLLAQQAFHDASFMLRPEHQQQVAAILHDpEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRV 121
Cdd:COG1951 4 IDPEDLTEAVAELIIEASYYLPPDVLEALKEALEK-EESPNAKDVLAQILENAEIAAEGKLPICQDTGTAVVFVKIGQDV 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 122 WTGGGDEAALSKGVFNTYIEDNLRYSQNAPLDmykEVNTGSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYqetka 201
Cdd:COG1951 83 PIDGDLEEAINEGVRRAYKEGPLRKSVVDPLT---RKNTGDNTPAVIHIEIVPGDKLEITVAPKGGGSENKSALK----- 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 202 LLTPGK----LKNFLVEKMRTLGTAACPPYHIAFVIGGTsAESTLKTVKLASTHYYDALPTEgnehgqaFRDLRLEQELL 277
Cdd:COG1951 155 MLNPSEglegVKKFVLETVKEAGGNPCPPGIVGVGIGGT-AEKAAKLAKKALLRPLDERNPD-------PRLAELEEELL 226
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445959348 278 EEAQKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNIKAKINREGIWieKLEHN 341
Cdd:COG1951 227 EAINKLGIGPQgLGGKTTALDVKIERAPRHIASLPVAVNINCWATRHATAVIDGDGPF--ELESP 289
|
|
| Fumerase |
pfam05681 |
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase ... |
48-324 |
1.83e-111 |
|
Fumarate hydratase (Fumerase); This family consists of several bacterial fumarate hydratase proteins FumA and FumB. Fumarase, or fumarate hydratase (EC 4.2.1.2), is a component of the citric acid cycle. In facultative anaerobes such as Escherichia coli, fumarase also engages in the reductive pathway from oxaloacetate to succinate during anaerobic growth. Three fumarases, FumA, FumB, and FumC, have been reported in E. coli. fumA and fumB genes are homologous and encode products of identical sizes which form thermolabile dimers of Mr 120,000. FumA and FumB are class I enzymes and are members of the iron-dependent hydrolases, which include aconitase and malate hydratase. The active FumA contains a 4Fe-4S centre, and it can be inactivated upon oxidation to give a 3Fe-4S centre.
Pssm-ID: 461713 Cd Length: 267 Bit Score: 332.46 E-value: 1.83e-111
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 48 TLLAQQAFHDASFMLRPEHQQQVAAILHDpEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGD 127
Cdd:pfam05681 1 TEAVAELIIEASTYLPPDVLEALKKALEK-EESPNAKFVLEQILENAEIAAEEKLPICQDTGMAVVFVKIGQDVHIEGGD 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 128 -EAALSKGVFNTYIEDNLRYSQNA-PLDmykEVNTGSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLYqetkaLLTP 205
Cdd:pfam05681 80 lEEAINEGVRRAYTEGPLRKSVVAdPLT---RKNTGDNTPAVIHIEIVPGDELKITVAPKGGGSENMSALK-----MLNP 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 206 G----KLKNFLVEKMRTLGTAACPPYHIAFVIGGTSAESTLKTVKlASthyYDALPTEG-NEHGQAFRDlrleqELLEEA 280
Cdd:pfam05681 152 AdgleGVKKFVLETVKEAGPNACPPYIVGVGIGGTFEKAALLAKK-AL---LRPLGTRNpDPRGAELEE-----ELLEAI 222
|
250 260 270 280
....*....|....*....|....*....|....*....|....*
gi 445959348 281 QKLGLGAQ-FGGKYFAHDIRVIRLPRHGASCPVGMGVSCSADRNI 324
Cdd:pfam05681 223 NKLGIGPQgLGGKTTALDVHIERAPTHIASLPVAVNVQCWADRHA 267
|
|
| FumA |
COG1838 |
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy ... |
361-548 |
3.69e-99 |
|
Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 441443 Cd Length: 190 Bit Score: 298.18 E-value: 3.69e-99
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 361 VDLNRPMKEIlaQLSQYPVSTRLSLTGTIIVGRDIAHAKLKERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTT 440
Cdd:COG1838 4 IRLNTPLTEE--DVRKLKAGDRVLLSGTIYTARDAAHKRLVELLDRGEPLPVDLKGQVIYYVGPAPAKPGYVIGSAGPTT 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 441 AGRMDSYVDLLQSHGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAqQSIKHLECVEYPELGMEAIWKIEVED 520
Cdd:COG1838 82 STRMDKYTPELLEELGLKGMIGKGGRSPEVIEAMKKHGAVYLAAVGGAAALLA-KAIKKVEVVAYEDLGPEAIWKLEVED 160
|
170 180
....*....|....*....|....*...
gi 445959348 521 FPAFILVDDKGNDFFQQIVSKQCANCAK 548
Cdd:COG1838 161 FPLIVAIDSKGNSLYEQGRAKARARLAA 188
|
|
| ttdB_fumA_fumB |
TIGR00723 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S ... |
372-537 |
3.40e-83 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, beta region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase beta chain and the C-terminal region of the class I fumarase (where the N-terminal region is homologous to the tartrate dehydratase alpha chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 129806 Cd Length: 168 Bit Score: 256.21 E-value: 3.40e-83
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 372 AQLSQYPVSTRLSLTGTIIVGRDIAHAKLKERIESGEDLPQYIKDHPIYYAGPAKTPAGYP-SGSLGPTTAGRMDSYVDL 450
Cdd:TIGR00723 1 EQILKLKVGDVVYLTGTIFTARDEAHARLLELIDEGKELPFDLNGSVIYHAGPIVTKNGEWeVVSVGPTTSARMNPFEPE 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 451 LQSHGGSMIMLAKGNRSQQVTDACKKHGGFYLGSIGGPAAVLAQQsIKHLECVEYPELGM-EAIWKIEVEDF-PAFILVD 528
Cdd:TIGR00723 81 LLEKLGVMAIIGKGGMSKEVVEACRKYKAVYLAFPGGCAALLAQS-VKKVEGVAWEDLGMpEAIWELEVEDFgPLIVAID 159
|
....*....
gi 445959348 529 DKGNDFFQQ 537
Cdd:TIGR00723 160 SHGNSIFQE 168
|
|
| PRK06842 |
PRK06842 |
Fe-S-containing hydro-lyase; |
385-536 |
1.31e-44 |
|
Fe-S-containing hydro-lyase;
Pssm-ID: 180724 [Multi-domain] Cd Length: 185 Bit Score: 156.10 E-value: 1.31e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 385 LTGTIIVGRDIAHAKLKERIESGEDLPQYIKDHPIYYAGPAKTPAGYPSGSLGPTTAGRMDSYVDLLQSHgGSMIMLAKG 464
Cdd:PRK06842 25 ISGYIYTARDAAHKRLIELLDKGEELPIDIKDQIIYYVGPSPAKPGKVIGSAGPTTSYRMDAYAPRLLDI-GLKGMIGKG 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 445959348 465 NRSQQVTDACKKHGGFYLGSIGGPAAVLAqQSIKHLECVEYPELGMEAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK06842 104 ARSDEVIESIKKNKAVYFGAIGGAAALIA-KSIKKSEVIAYEDLGAEAIRKLEVKDFPVVVIIDSEGNNLYE 174
|
|
| PRK06246 |
PRK06246 |
fumarate hydratase; Provisional |
78-328 |
1.19e-31 |
|
fumarate hydratase; Provisional
Pssm-ID: 180486 Cd Length: 280 Bit Score: 123.35 E-value: 1.19e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 78 EASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGD-EAALSKGVFNTYIEDNLRysQNAPLDMYK 156
Cdd:PRK06246 39 EESPIGKEILKAILENAEIAKEEQVPLCQDTGMAVVFVEIGQDVHIEGGDlEDAINEGVRKGYEEGYLR--KSVVADPLT 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 157 EVNTGSNLPAQIDLYAVDGDEYKFLCVAKGGGSANKTYLyqetkALLTPG----KLKNFLVEKMRTLGTAACPPYHIAFV 232
Cdd:PRK06246 117 RKNTGDNTPAVIHTEIVPGDKLKITVAPKGGGSENMSAL-----KMLKPAdgleGIKKFVLETVKEAGGNPCPPIIVGVG 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 233 IGGTsAEstlKTVKLASThyydALptegnehgqaFRDLRLEQELLEEAQ----------KLGLGAQ-FGGKYFAHDIRVI 301
Cdd:PRK06246 192 IGGT-FD---KAAKLAKK----AL----------LRPIGERNPDPEIAAleeelleeinKLGIGPMgLGGKTTALDVKIE 253
|
250 260
....*....|....*....|....*..
gi 445959348 302 RLPRHGASCPVGMGVSCSADRNIKAKI 328
Cdd:PRK06246 254 TYPCHIASLPVAVNIQCHAARHAEVVL 280
|
|
| ttdA_fumA_fumB |
TIGR00722 |
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S ... |
74-328 |
5.28e-29 |
|
hydro-lyases, Fe-S type, tartrate/fumarate subfamily, alpha region; A number of Fe-S cluster-containing hydro-lyases share a conserved motif, including argininosuccinate lyase, adenylosuccinate lyase, aspartase, class I fumarate hydratase (fumarase), and tartrate dehydratase (see PROSITE:PDOC00147). This model represents a subset of closely related proteins or modules, including the E. coli tartrate dehydratase alpha chain and the N-terminal region of the class I fumarase (where the C-terminal region is homologous to the tartrate dehydratase beta chain). The activity of archaeal proteins in this subfamily has not been established.
Pssm-ID: 273234 Cd Length: 273 Bit Score: 116.02 E-value: 5.28e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 74 LHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYSQNAPLD 153
Cdd:TIGR00722 27 AYDREESEIAKINLEAILDNIEIAEKLGVPVCQDTGVPIFFVKVGSRFVLIGKLYEAIKQGVEEATEEVPLRPNAVHPLT 106
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 154 mykEVNTGSNL---PAQIDLYAVDGDEYKFLCVAKGGGSANKTYLyqetkALLTPG----KLKNFLVEKMRTLGTAACPP 226
Cdd:TIGR00722 107 ---RENTGDNTglgVPQIHVEIVPGDELEIVVFPKGAGSENPSAL-----KMLKPSdgieGVKKFVLETVKNAGGKPCPP 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 227 YHIAFVIGGTsAESTLKTVKLAsthyydALPTEGNEHGQAfRDLRLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLPR 305
Cdd:TIGR00722 179 IIVGVGIGGS-FETAAKLAKKA------LLRPIGERHPNP-KIAKLELELLEEINSLGIGPMgLGGKTTALDVKIESAHC 250
|
250 260
....*....|....*....|...
gi 445959348 306 HGASCPVGMGVSCSADRNIKAKI 328
Cdd:TIGR00722 251 HTASLPVAVNIQCWAHRRATLVV 273
|
|
| PRK06043 |
PRK06043 |
fumarate hydratase; Provisional |
385-541 |
8.40e-27 |
|
fumarate hydratase; Provisional
Pssm-ID: 180366 Cd Length: 192 Bit Score: 107.15 E-value: 8.40e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 385 LTGTIIVGRDIAHAKLKERIESGEDLPQYIKDHPIYYAGP--AKTPAGYPSGSLGPTTAGRMDSYV-DLLQSHgGSMIML 461
Cdd:PRK06043 25 ISGEILTARDEAHARILEMKEKGKELPFSLEGAVIYHCGPlmKKTDEGWKVVSAGPTTSARMSKMTpKLLEKV-EVRAII 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 462 AKGNRsQQVTDACKKhGGFYLGSIGGPAAvLAQQSIKHLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQIV 539
Cdd:PRK06043 104 GKGGM-KNVADALKG-KCVYLAYTGGCAA-LAAESIKRVKAVHWLDLGMpEAVWVLEVEEFgPLIVGIDAKGNDLYSEVR 180
|
..
gi 445959348 540 SK 541
Cdd:PRK06043 181 EK 182
|
|
| PRK08228 |
PRK08228 |
L(+)-tartrate dehydratase subunit beta; Validated |
385-537 |
6.86e-25 |
|
L(+)-tartrate dehydratase subunit beta; Validated
Pssm-ID: 236192 Cd Length: 204 Bit Score: 102.44 E-value: 6.86e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 385 LTGTIIVGRDIAHAKLkerIESGEDLPQYIKDHPIYYAGP----AKTPAGYPSGSLGPTTAGRMDSYVDLLQSHGGSMIM 460
Cdd:PRK08228 26 LTGTLVTCRDVAHRRL---IELGRELPVDLNGGAIFHAGPivrpKKNDDKFEMVSVGPTTSMRMEKFEKEFIEQTGVKLI 102
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445959348 461 LAKGNRSQQVTDACKKHGGFYLGSIGGpAAVLAQQSIKHLECVEYPELGM-EAIWKIEVEDF-PAFILVDDKGNDFFQQ 537
Cdd:PRK08228 103 VGKGGMGPGTEEGCQEFKALHCVFPAG-CAVLAATQVEEIEDAQWRDLGMpETLWVCRVKEFgPLIVSIDTHGNNLFEE 180
|
|
| PRK08395 |
PRK08395 |
fumarate hydratase; Provisional |
379-536 |
8.30e-16 |
|
fumarate hydratase; Provisional
Pssm-ID: 169425 Cd Length: 162 Bit Score: 75.23 E-value: 8.30e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 379 VSTRLSLTGTIIVGRDIAHAKLKEriesgEDLPQYIKDHPIYYAGPAKTPAGYPSGslGPTTAGRMDSYVDLLQSHGGSM 458
Cdd:PRK08395 17 AGDVVYLSGIIYTARDLAHRRFLS-----EGFPFNPEGAVIYHCGPLVKNKKIVSA--GPTTSARMNKYLDFLFSLGVRG 89
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445959348 459 IMLAKGNRSQQVtdackKHGGFYLGSIGGpAAVLAQQSIKHLECVEYPELGM-EAIWKIEVEDFPAFILVDDKGNDFFQ 536
Cdd:PRK08395 90 IIGKGGMNAEPF-----KGRAVYFAFPGG-AGSLAAKSIKRVRDVYWEDLGMpDAVWELEVEDFPLLVAIDSKGRSLYR 162
|
|
| PRK08230 |
PRK08230 |
tartrate dehydratase subunit alpha; Validated |
74-331 |
2.85e-07 |
|
tartrate dehydratase subunit alpha; Validated
Pssm-ID: 181309 Cd Length: 299 Bit Score: 52.40 E-value: 2.85e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 74 LHDPEASENDKYVALQFLRNSEIAAKGVLPTCQDTGTAIIMGKKGQRVWTGGGDEAALSKGVFNTYIEDNLRYsqNApLD 153
Cdd:PRK08230 36 LKDAETSPLAKIIYDTMFENQQLAIDLNRPSCQDTGVIQFFVKVGARFPLLGELESILKEAVEEATVKAPLRH--NA-VE 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 154 MYKEVNTGSNLPAQI---DLYAV-DGDEYKFLCVAKGGGSAnktyLYQETKALLtPGK----LKNFLVEKMRTLGTAACP 225
Cdd:PRK08230 113 TFDEYNTGKNTGSGVpwvFWEIVpDSDDAEIEVYMAGGGCT----LPGRAKVLM-PGEgyegVVKFVFDVITSYGVNACP 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445959348 226 PYHIAFVIgGTSAESTLKTVKLAsthyydALPTEGNEHGQAfRDLRLEQELLEEAQKLGLGAQ-FGGKYFAHDIRVIRLP 304
Cdd:PRK08230 188 PLLVGVGI-ATSVETAAVLSKKA------ILRPIGSRNPNP-RAAELEKRLEEGLNRIGLGPQgLTGNSSVMGVNIESAA 259
|
250 260
....*....|....*....|....*..
gi 445959348 305 RHGASCPVGMGVSCSADRNIKAKINRE 331
Cdd:PRK08230 260 RHPSTIGVAVSTGCWAHRRGTIVFDAD 286
|
|
| |
