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Conserved domains on  [gi|445958469|ref|WP_000036324|]
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DUF1648 domain-containing protein [Staphylococcus aureus]

Protein Classification

DUF1648 domain-containing protein( domain architecture ID 10545185)

DUF1648 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SdpI super family cl35040
Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family ...
 3-144 6.05e-10

Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family [Defense mechanisms];


The actual alignment was detected with superfamily member COG5658:

Pssm-ID: 444377 [Multi-domain]  Cd Length: 216  Bit Score: 55.23  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445958469   3 KIRSFTILSLLIYLAMMCYTVATYSKLPTKVPIHYNLAGDADNFADKWVLLLINSAFIVIWLIFFIA-------GRYYER 75
Cdd:COG5658    2 KKKWSLILSLLLILLSLILGLLAYPQLPDQVPTHWNAAGEVDGYGSKLEGAFLLPLLMLGLYLLFLVlpridpkKENYEK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445958469  76 FAKwshynhTPREIRAIKLFLstlnleiMSYMSIFTVLEIWQIQhhhqfnlLWFNMIFIIIIGLTLVIF 144
Cdd:COG5658   82 FRK------VYRLIRVLIVLF-------MLVIHLVTLLAALGYE-------INVGRVVPLGIGLLFIVI 130
 
Name Accession Description Interval E-value
SdpI COG5658
Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family ...
 3-144 6.05e-10

Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family [Defense mechanisms];


Pssm-ID: 444377 [Multi-domain]  Cd Length: 216  Bit Score: 55.23  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445958469   3 KIRSFTILSLLIYLAMMCYTVATYSKLPTKVPIHYNLAGDADNFADKWVLLLINSAFIVIWLIFFIA-------GRYYER 75
Cdd:COG5658    2 KKKWSLILSLLLILLSLILGLLAYPQLPDQVPTHWNAAGEVDGYGSKLEGAFLLPLLMLGLYLLFLVlpridpkKENYEK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445958469  76 FAKwshynhTPREIRAIKLFLstlnleiMSYMSIFTVLEIWQIQhhhqfnlLWFNMIFIIIIGLTLVIF 144
Cdd:COG5658   82 FRK------VYRLIRVLIVLF-------MLVIHLVTLLAALGYE-------INVGRVVPLGIGLLFIVI 130
DUF1648 pfam07853
Domain of unknown function (DUF1648); This domain is found in proteins expressed by bacterial ...
 13-61 7.62e-08

Domain of unknown function (DUF1648); This domain is found in proteins expressed by bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues. One protein containing this domain is immunity protein SdpI (swiss:O32241) from Bacillus subtilis, which provides protection for the cell against the toxic effects of its own SdpC killing factor, and also functions as a receptor/signal transduction protein.


Pssm-ID: 462289 [Multi-domain]  Cd Length: 49  Bit Score: 46.21  E-value: 7.62e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 445958469   13 LIYLAMMCYTVATYSKLPTKVPIHYNLAGDADNFADKWVLLLINSAFIV 61
Cdd:pfam07853   1 LLLLLTLIVGLIAYPSLPDQIPTHWNASGEPDGYGSKLFGLFLLPLLML 49
 
Name Accession Description Interval E-value
SdpI COG5658
Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family ...
 3-144 6.05e-10

Bacterial immunity/signal transduction membrane protein SdpI, SdpI/YbgB/DUF1648 family [Defense mechanisms];


Pssm-ID: 444377 [Multi-domain]  Cd Length: 216  Bit Score: 55.23  E-value: 6.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445958469   3 KIRSFTILSLLIYLAMMCYTVATYSKLPTKVPIHYNLAGDADNFADKWVLLLINSAFIVIWLIFFIA-------GRYYER 75
Cdd:COG5658    2 KKKWSLILSLLLILLSLILGLLAYPQLPDQVPTHWNAAGEVDGYGSKLEGAFLLPLLMLGLYLLFLVlpridpkKENYEK 81

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 445958469  76 FAKwshynhTPREIRAIKLFLstlnleiMSYMSIFTVLEIWQIQhhhqfnlLWFNMIFIIIIGLTLVIF 144
Cdd:COG5658   82 FRK------VYRLIRVLIVLF-------MLVIHLVTLLAALGYE-------INVGRVVPLGIGLLFIVI 130
DUF1648 pfam07853
Domain of unknown function (DUF1648); This domain is found in proteins expressed by bacterial ...
 13-61 7.62e-08

Domain of unknown function (DUF1648); This domain is found in proteins expressed by bacterial or archaeal species. Some of these are annotated as being transmembrane proteins, and in fact many of these sequences contain a high proportion of hydrophobic residues. One protein containing this domain is immunity protein SdpI (swiss:O32241) from Bacillus subtilis, which provides protection for the cell against the toxic effects of its own SdpC killing factor, and also functions as a receptor/signal transduction protein.


Pssm-ID: 462289 [Multi-domain]  Cd Length: 49  Bit Score: 46.21  E-value: 7.62e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 445958469   13 LIYLAMMCYTVATYSKLPTKVPIHYNLAGDADNFADKWVLLLINSAFIV 61
Cdd:pfam07853   1 LLLLLTLIVGLIAYPSLPDQIPTHWNASGEPDGYGSKLFGLFLLPLLML 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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