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Conserved domains on  [gi|445955000|ref|WP_000032855|]
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MULTISPECIES: SarA family transcriptional regulator [Staphylococcus]

Protein Classification

SarA family transcriptional regulator( domain architecture ID 10020028)

SarA family transcriptional regulator similar to staphylococcal accessory regulators SarA, SarS, SarT, SarU, SarX

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 129-237 1.08e-27

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


:

Pssm-ID: 130944  Cd Length: 109  Bit Score: 101.95  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000  129 CDYVSYLLSSQELLRNLKCYLNMCQLSLEELYVLGILNLHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCEL 208
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*....
gi 445955000  209 DERRVIVTIKREKFSKVTMLIQACYNYLE 237
Cdd:TIGR01889  81 DERKVIISINKEQRSKIESLISEIEQIIK 109
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 7-117 1.11e-23

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


:

Pssm-ID: 130944  Cd Length: 109  Bit Score: 91.55  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000    7 KRLTAHILMLKVINDMLKYSFHLTLTQVKLLNLLVKYDNSDsNSASIDSLLKMKEIQsKMALLQMLSYLNNHQWLLKGRD 86
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKLENNE-GKLTLKEIIKEILIK-QSALVKIIKKLSKKGYLSKERS 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 445955000   87 QRDQRKLTISINKMHIDKIEYMNNELSDYIE 117
Cdd:TIGR01889  79 EDDERKVIISINKEQRSKIESLISEIEQIIK 109
 
Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 129-237 1.08e-27

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 101.95  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000  129 CDYVSYLLSSQELLRNLKCYLNMCQLSLEELYVLGILNLHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCEL 208
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*....
gi 445955000  209 DERRVIVTIKREKFSKVTMLIQACYNYLE 237
Cdd:TIGR01889  81 DERKVIISINKEQRSKIESLISEIEQIIK 109
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 7-117 1.11e-23

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 91.55  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000    7 KRLTAHILMLKVINDMLKYSFHLTLTQVKLLNLLVKYDNSDsNSASIDSLLKMKEIQsKMALLQMLSYLNNHQWLLKGRD 86
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKLENNE-GKLTLKEIIKEILIK-QSALVKIIKKLSKKGYLSKERS 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 445955000   87 QRDQRKLTISINKMHIDKIEYMNNELSDYIE 117
Cdd:TIGR01889  79 EDDERKVIISINKEQRSKIESLISEIEQIIK 109
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
138-217 2.52e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 43.03  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000 138 SQELLRNLKCYLNMCQLSLEELYVLGILNlHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCELDERRVIVTI 217
Cdd:COG1846   20 ARALRRALDRALAELGLTPAQFRVLAALA-EAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRL 98
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 153-212 4.94e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.26  E-value: 4.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000  153 QLSLEELYVLGILNLHKGqLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCELDERR 212
Cdd:pfam12802   2 GLTPAQFRVLLALARNPG-LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
154-217 3.12e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 39.11  E-value: 3.12e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445955000   154 LSLEELYVLGILNlHKGQLTVKEL--QGEFHHPifAVSPILKCLILKGLVKKERCELDERRVIVTI 217
Cdd:smart00347   8 LTPTQFLVLRILY-EEGPLSVSELakRLGVSPS--TVTRVLDRLEKKGLVRREPSPEDRRSVLVSL 70
 
Name Accession Description Interval E-value
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 129-237 1.08e-27

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 101.95  E-value: 1.08e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000  129 CDYVSYLLSSQELLRNLKCYLNMCQLSLEELYVLGILNLHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCEL 208
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKLENNEGKLTLKEIIKEILIKQSALVKIIKKLSKKGYLSKERSED 80

                          90       100
                  ....*....|....*....|....*....
gi 445955000  209 DERRVIVTIKREKFSKVTMLIQACYNYLE 237
Cdd:TIGR01889  81 DERKVIISINKEQRSKIESLISEIEQIIK 109
Staph_reg_Sar TIGR01889
staphylococcal accessory regulator family; This model represents a family of transcriptional ...
 7-117 1.11e-23

staphylococcal accessory regulator family; This model represents a family of transcriptional regulatory proteins in Staphylococcus aureus and Staphylococcus epidermidis. Some members contain two tandem copies of this region. This family is related to the MarR transcriptional regulator family described by pfam01047. [Regulatory functions, DNA interactions]


Pssm-ID: 130944  Cd Length: 109  Bit Score: 91.55  E-value: 1.11e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000    7 KRLTAHILMLKVINDMLKYSFHLTLTQVKLLNLLVKYDNSDsNSASIDSLLKMKEIQsKMALLQMLSYLNNHQWLLKGRD 86
Cdd:TIGR01889   1 KDLLSLYLYIKSLKRYLKKEFNLSLEELLILYYLGKLENNE-GKLTLKEIIKEILIK-QSALVKIIKKLSKKGYLSKERS 78

                          90       100       110
                  ....*....|....*....|....*....|.
gi 445955000   87 QRDQRKLTISINKMHIDKIEYMNNELSDYIE 117
Cdd:TIGR01889  79 EDDERKVIISINKEQRSKIESLISEIEQIIK 109
MarR COG1846
DNA-binding transcriptional regulator, MarR family [Transcription];
138-217 2.52e-05

DNA-binding transcriptional regulator, MarR family [Transcription];


Pssm-ID: 441451 [Multi-domain]  Cd Length: 142  Bit Score: 43.03  E-value: 2.52e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000 138 SQELLRNLKCYLNMCQLSLEELYVLGILNlHKGQLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCELDERRVIVTI 217
Cdd:COG1846   20 ARALRRALDRALAELGLTPAQFRVLAALA-EAGGLTQSELAERLGLTKSTVSRLLDRLEEKGLVEREPDPEDRRAVLVRL 98
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 153-212 4.94e-05

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 40.26  E-value: 4.94e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 445955000  153 QLSLEELYVLGILNLHKGqLTVKELQGEFHHPIFAVSPILKCLILKGLVKKERCELDERR 212
Cdd:pfam12802   2 GLTPAQFRVLLALARNPG-LTVAELARRLGISKQTVSRLVKRLEAKGLVEREPSPADRRA 60
HTH_MARR smart00347
helix_turn_helix multiple antibiotic resistance protein;
154-217 3.12e-04

helix_turn_helix multiple antibiotic resistance protein;


Pssm-ID: 197670 [Multi-domain]  Cd Length: 101  Bit Score: 39.11  E-value: 3.12e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445955000   154 LSLEELYVLGILNlHKGQLTVKEL--QGEFHHPifAVSPILKCLILKGLVKKERCELDERRVIVTI 217
Cdd:smart00347   8 LTPTQFLVLRILY-EEGPLSVSELakRLGVSPS--TVTRVLDRLEKKGLVRREPSPEDRRSVLVSL 70
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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