2-methylaconitate cis-trans isomerase PrpF family protein similar to PrpF that isomerizes trans-aconitate to cis-aconitate through a base-catalyzed proton abstraction coupled with a rotation about the C2-C3 bond of 2-methylaconitate
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally ...
5-395
0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerize trans-aconitate to cis-aconitate.
The actual alignment was detected with superfamily member TIGR02334:
Pssm-ID: 450302 Cd Length: 390 Bit Score: 730.10 E-value: 0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five ...
5-395
0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of pfam04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. [Energy metabolism, Fermentation]
Pssm-ID: 131387 Cd Length: 390 Bit Score: 730.10 E-value: 0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally ...
6-391
0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerize trans-aconitate to cis-aconitate.
Pssm-ID: 398133 Cd Length: 384 Bit Score: 616.10 E-value: 0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five ...
5-395
0e+00
probable AcnD-accessory protein PrpF; The 2-methylcitrate cycle is one of at least five degradation pathways for propionate via propionyl-CoA. Degradation of propionate toward pyruvate consumes oxaloacetate and releases succinate. Oxidation of succinate back into oxaloacetate by the TCA cycle makes the 2-methylcitrate pathway a cycle. This family consists of PrpF, an incompletely characterized protein that appears to be an essential accessory protein for the Fe/S-dependent 2-methylisocitrate dehydratase AcnD (TIGR02333). This protein is related to but distinct from FldA (part of pfam04303), a putative fluorene degradation protein of Sphingomonas sp. LB126. [Energy metabolism, Fermentation]
Pssm-ID: 131387 Cd Length: 390 Bit Score: 730.10 E-value: 0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally ...
6-391
0e+00
PrpF protein; PrpF is a protein found in the 2-methylcitrate pathway. It is structurally similar to DAP epimerase and proline racemase. This protein is likely to acts to isomerize trans-aconitate to cis-aconitate.
Pssm-ID: 398133 Cd Length: 384 Bit Score: 616.10 E-value: 0e+00
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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Functional characterization of the conserved domain architecture found on the query.
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This image shows a graphical summary of conserved domains identified on the query sequence.
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if a domain or superfamily has been annotated with functional sites (conserved features),
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The table lists conserved domains identified on the query sequence. Click on the plus sign (+) on the left to display full descriptions, alignments, and scores.
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Concise Display shows only the best scoring domain model, in each hit category listed below except non-specific hits, for each region on the query sequence.
(labeled illustration) Standard Display shows only the best scoring domain model from each source, in each hit category listed below for each region on the query sequence.
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