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Conserved domains on  [gi|445930701|ref|WP_000008556|]
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MULTISPECIES: helix-turn-helix transcriptional regulator [Gammaproteobacteria]

Protein Classification

ArsR/SmtB family transcription factor( domain architecture ID 10001925)

ArsR (Arsenical Resistance Operon Repressor)/SmtB family transcription factor is a winged-helix-turn-helix transcriptional regulator that may be metal-sensing and modulate the expression of genes associated with metal homeostasis

Gene Ontology:  GO:0003700|GO:0006355|GO:0003677
PubMed:  10473770|28436329|12829264|28512703|30191942|15808743

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
12-100 6.32e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


:

Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.87  E-value: 6.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445930701  12 QEEIMSLAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQ 91
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAE 83


                 ....*....
gi 445930701  92 VLSDMAKHI 100
Cdd:COG0640   84 LLEWLLELL 92
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
12-100 6.32e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.87  E-value: 6.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445930701  12 QEEIMSLAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQ 91
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAE 83


                 ....*....
gi 445930701  92 VLSDMAKHI 100
Cdd:COG0640   84 LLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-93 8.69e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 88.67  E-value: 8.69e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445930701  18 LAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQVL 93
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-98 6.11e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.86  E-value: 6.11e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445930701  22 FRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDI-HVSQVLSDMAK 98
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-96 6.08e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.08  E-value: 6.08e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445930701    32 KILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQVLSDM 96
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 8.33e-13

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 58.19  E-value: 8.33e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445930701  21 TFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEI 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 27-71 2.23e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.23e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 445930701   27 DASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLV 71
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 22-84 7.35e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 38.64  E-value: 7.35e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445930701  22 FRLLGDASRLKI-LLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEI 84
Cdd:PRK10141  10 FKILSDETRLGIvLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Name Accession Description Interval E-value
ArsR COG0640
DNA-binding transcriptional regulator, ArsR family [Transcription];
12-100 6.32e-26

DNA-binding transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 440405 [Multi-domain]  Cd Length: 92  Bit Score: 91.87  E-value: 6.32e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445930701  12 QEEIMSLAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQ 91
Cdd:COG0640    4 TKELEELAELFKALADPTRLRILRLLAEGELCVGELAEALGLSQSTVSHHLKVLREAGLVTSRREGRWVYYRLADEALAE 83


                 ....*....
gi 445930701  92 VLSDMAKHI 100
Cdd:COG0640   84 LLEWLLELL 92
HTH_metalloreg NF033788
metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense ...
 18-93 8.69e-25

metalloregulator ArsR/SmtB family transcription factor; Transcriptional repressors that sense toxic heavy metals such as arsenic or cadmium, and are released from DNA so that resistance factors will be expressed, include ArsR, SmtB, ZiaR, CadC, CadX, KmtR, etc. However, some members of this family, including the sporulation delaying system autorepressor SdpR and its family (see NF033789), may lack metal-binding cites and instead regulate other cellular processes.


Pssm-ID: 411368 [Multi-domain]  Cd Length: 76  Bit Score: 88.67  E-value: 8.69e-25
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 445930701  18 LAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQVL 93
Cdd:NF033788   1 LAELFKALADPTRLRILELLAEGELCVCELAEALGLSQSAVSQHLKVLRDAGLVTSRREGRWVYYRLADEHVAELL 76
HTH_ARSR cd00090
Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric ...
 22-98 6.11e-17

Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to dissociate from DNA in the presence of metal ions.


Pssm-ID: 238042 [Multi-domain]  Cd Length: 78  Bit Score: 68.86  E-value: 6.11e-17
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 445930701  22 FRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDI-HVSQVLSDMAK 98
Cdd:cd00090    1 LKALSDPTRLRILRLLLEGPLTVSELAERLGLSQSTVSRHLKKLEEAGLVESRREGRRVYYSLTDAeRLLALLESLLE 78
HTH_ARSR smart00418
helix_turn_helix, Arsenical Resistance Operon Repressor;
32-96 6.08e-16

helix_turn_helix, Arsenical Resistance Operon Repressor;


Pssm-ID: 197713 [Multi-domain]  Cd Length: 66  Bit Score: 66.08  E-value: 6.08e-16
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 445930701    32 KILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDDIHVSQVLSDM 96
Cdd:smart00418   1 KILKLLAEGELCVCELAEILGLSQSTVSHHLKKLREAGLVESRREGKRVYYSLTDEKVADLLEEL 65
repress_SdpR NF033789
autorepressor SdpR family transcription factor; Transcription factors in the family of the ...
 21-84 8.33e-13

autorepressor SdpR family transcription factor; Transcription factors in the family of the sporulation delaying system autorepressor SdpR (of Bacillus subtilis) resemble metalloregulatory transcriptional repressors such as ArsR, SmtB, CadX, ZiaR, etc., but may lack the key metal-binding residues.


Pssm-ID: 411369 [Multi-domain]  Cd Length: 79  Bit Score: 58.19  E-value: 8.33e-13
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445930701  21 TFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEI 84
Cdd:NF033789   1 TFKALSDPTRREILELLKEGDMTAGEIAEHFDMSKPSISHHLNILKQADLVTDERKGQFIYYSL 64
COG4189 COG4189
Predicted transcriptional regulator, ArsR family [Transcription];
10-90 1.58e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 443343 [Multi-domain]  Cd Length: 97  Bit Score: 55.35  E-value: 1.58e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445930701  10 LSQEEIMSLAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQA------KQVFYE 83
Cdd:COG4189    1 MVVLDDEESLEVLKALASETRLRILRLLAEEPLNVNELAEALGLPKSTVSYHIRKLEEAGLIRTEYKPgkrgrqKICYLR 80


                 ....*..
gi 445930701  84 IDDIHVS 90
Cdd:COG4189   81 VDKILIV 87
COG1777 COG1777
Predicted transcriptional regulator, ArsR family [Transcription];
13-75 4.82e-11

Predicted transcriptional regulator, ArsR family [Transcription];


Pssm-ID: 441383  Cd Length: 113  Bit Score: 54.65  E-value: 4.82e-11
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 445930701  13 EEIMSLAETFRLLGDASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGER 75
Cdd:COG1777    2 SDDEDLDRLLDALGNPTRRRILALLSEEPAYVSELARELGVSRQAVYKHLRKLEEAGLVESYR 64
HTH_5 pfam01022
Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding ...
 27-71 2.23e-10

Bacterial regulatory protein, arsR family; Members of this family contains a DNA binding 'helix-turn-helix' motif. This family includes other proteins which are not included in the Prosite definition.


Pssm-ID: 425993 [Multi-domain]  Cd Length: 45  Bit Score: 51.29  E-value: 2.23e-10
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 445930701   27 DASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLV 71
Cdd:pfam01022   1 DPTRLKILKLLAEGELCVCELAEELGLSQSTVSHHLKKLREAGLV 45
HTH_20 pfam12840
Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in ...
 19-78 2.69e-09

Helix-turn-helix domain; This domain represents a DNA-binding Helix-turn-helix domain found in transcriptional regulatory proteins.


Pssm-ID: 432824 [Multi-domain]  Cd Length: 61  Bit Score: 48.69  E-value: 2.69e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 445930701   19 AETFRLLGDASRLKIL-LFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAK 78
Cdd:pfam12840   1 DDVAEALADPTRLRILrALVGDEPLTASELARRLDISRNTLSYHLRKLEEAGLVEVVREGR 61
COG3398 COG3398
Predicted transcriptional regulator, contains two HTH domains [Transcription];
32-86 9.91e-07

Predicted transcriptional regulator, contains two HTH domains [Transcription];


Pssm-ID: 442625 [Multi-domain]  Cd Length: 159  Bit Score: 44.10  E-value: 9.91e-07
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 445930701  32 KILLFCMRGPS-SVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEIDD 86
Cdd:COG3398  101 RILLYLLENPGaTNKELAEELGISRSTVSWHLKRLEEDGLVERERDGRNVRYYLNP 156
GbsR COG1510
DNA-binding transcriptional regulator GbsR, MarR family [Transcription];
1-86 2.83e-06

DNA-binding transcriptional regulator GbsR, MarR family [Transcription];


Pssm-ID: 441119  Cd Length: 164  Bit Score: 43.00  E-value: 2.83e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 445930701   1 MSFKDHPTElsQEEIMSLAETFRLLG---DASRLKILLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQA 77
Cdd:COG1510    1 MSEKLEEAK--ERFIEAFGEMGERWGlprSAGRIYALLYLSDEPLTADELAEELGVSKSSVSTALRELEDWGLVRRVRKP 78

                         90
                 ....*....|.
gi 445930701  78 --KQVFYEIDD 86
Cdd:COG1510   79 gdRKDYFRAEK 89
PRK10141 PRK10141
DNA-binding transcriptional repressor ArsR; Provisional
 22-84 7.35e-05

DNA-binding transcriptional repressor ArsR; Provisional


Pssm-ID: 236654  Cd Length: 117  Bit Score: 38.64  E-value: 7.35e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 445930701  22 FRLLGDASRLKI-LLFCMRGPSSVGEISDALDLSQSLVSHNLRLLRSARLVKGERQAKQVFYEI 84
Cdd:PRK10141  10 FKILSDETRLGIvLLLRESGELCVCDLCTALDQSQPKISRHLALLRESGLLLDRKQGKWVHYRL 73
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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