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Conserved domains on  [gi|2517005960|gb|WIR57769|]
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ornithine carbamoyltransferase [Bordetella pertussis]

Protein Classification

ornithine carbamoyltransferase( domain architecture ID 11479232)

ornithine carbamoyltransferase reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to L-ornithine (ORN) to produce L-citrulline, as part of the urea cycle and L-arginine biosynthesis

CATH:  3.40.50.720
EC:  2.1.3.3
Gene Ontology:  GO:0004585|GO:0006591|GO:0006526
PubMed:  18062991

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 12-308 0e+00

ornithine carbamoyltransferase; Provisional


:

Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 583.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:PRK00779    5 RHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:PRK00779   85 GEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGDGNNV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPARIGAPAA---GVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAAFAD 248
Cdd:PRK00779  165 ANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIAKetgASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFAP 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 249 WCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:PRK00779  245 YQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 12-308 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 583.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:PRK00779    5 RHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:PRK00779   85 GEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGDGNNV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPARIGAPAA---GVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAAFAD 248
Cdd:PRK00779  165 ANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIAKetgASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFAP 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 249 WCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:PRK00779  245 YQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 12-310 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 525.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:COG0078     6 RHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLGR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:COG0078    86 GESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVGDGNNV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPA------RIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAA 245
Cdd:COG0078   166 ANSLLLAAAKLGMDVRIATPEGYEPDPEivakakEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAEERIKA 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2517005960 246 FADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLLLG 310
Cdd:COG0078   246 FKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 12-308 1.77e-142

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 404.04  E-value: 1.77e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPA------RIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAA 245
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADivkkaqEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2517005960 246 FADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALL 303
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
13-152 5.63e-74

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 223.84  E-value: 5.63e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  13 HFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGRS 92
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  93 EPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIE 152
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
 
Name Accession Description Interval E-value
PRK00779 PRK00779
ornithine carbamoyltransferase; Provisional
 12-308 0e+00

ornithine carbamoyltransferase; Provisional


Pssm-ID: 234835 [Multi-domain]  Cd Length: 304  Bit Score: 583.59  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:PRK00779    5 RHFLSLDDLSPEELEELLDLAAELKKKRKAGEPHPPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIFLSPRDTQLGR 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:PRK00779   85 GEPIEDTARVLSRYVDAIMIRTFEHETLEELAEYSTVPVINGLTDLSHPCQILADLLTIYEHRGSLKGLKVAWVGDGNNV 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPARIGAPAA---GVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAAFAD 248
Cdd:PRK00779  165 ANSLLLAAALLGFDLRVATPKGYEPDPEIVEKIAKetgASIEVTHDPKEAVKGADVVYTDVWVSMGQEAEAEERLKAFAP 244

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 249 WCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:PRK00779  245 YQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVWDEAENRLHAQKALLAWLL 304
ArgF COG0078
Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine ...
 12-310 0e+00

Ornithine carbamoyltransferase [Amino acid transport and metabolism]; Ornithine carbamoyltransferase is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 439848 [Multi-domain]  Cd Length: 310  Bit Score: 525.00  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:COG0078     6 RHFLSLLDLTPEELRALLDLAAELKAKRKAGIPHRPLKGKTLAMIFEKPSTRTRVSFEVGMAQLGGHAIYLDPGDSQLGR 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:COG0078    86 GESIKDTARVLSRYVDGIMIRTFGHETLEELAKYAGVPVINGLTDLFHPCQALADLLTIREHFGKLKGLKVAYVGDGNNV 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPA------RIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAA 245
Cdd:COG0078   166 ANSLLLAAAKLGMDVRIATPEGYEPDPEivakakEIAAESGGSITITHDPAEAVKGADVVYTDVWVSMGQEEEAEERIKA 245

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 2517005960 246 FADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLLLG 310
Cdd:COG0078   246 FKPYQVNEELMALAKPDAIFMHCLPAHRGEEVTDEVIDGPQSVVFDEAENRLHAQKALLAWLLGG 310
orni_carb_tr TIGR00658
ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in ...
 12-308 1.77e-142

ornithine carbamoyltransferase; This family of ornithine carbamoyltransferases (OTCase) is in a superfamily with the related enzyme aspartate carbamoyltransferase. Most known examples are anabolic, playing a role in arginine biosynthesis, but some are catabolic. Most OTCases are homotrimers, but the homotrimers are organized into dodecamers built from four trimers in at least two species; the catabolic OTCase of Pseudomonas aeruginosa is allosterically regulated, while OTCase of the extreme thermophile Pyrococcus furiosus shows both allostery and thermophily. [Amino acid biosynthesis, Glutamate family]


Pssm-ID: 129743 [Multi-domain]  Cd Length: 304  Bit Score: 404.04  E-value: 1.77e-142
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:TIGR00658   1 RHLLSLLDLSPEEIRYLLQLAKKLKKGKKKGKEHKKLKGKTLALIFEKPSTRTRVSFEVAAYQLGGHPLYLNPNDLQLGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNM 171
Cdd:TIGR00658  81 GESIKDTARVLSRYVDGIMARVYKHEDVEELAKYASVPVINGLTDLFHPCQALADLLTIIEHFGKLKGVKVVYVGDGNNV 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 172 SYTWLQAAEMLGFTLHVSTPAGYELDPA------RIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAA 245
Cdd:TIGR00658 161 CNSLMLAGAKLGMDVVVATPEGYEPDADivkkaqEIAKENGGSVELTHDPVEAVKGADVIYTDVWVSMGEEDKKEERLKL 240

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2517005960 246 FADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:TIGR00658 241 FRPYQVNEELMELAKPEVIFMHCLPAHRGEEVTDEVIEGPHSIVFDQAENRLHAQKAVMVALL 303
PLN02342 PLN02342
ornithine carbamoyltransferase
 11-308 1.94e-118

ornithine carbamoyltransferase


Pssm-ID: 177976 [Multi-domain]  Cd Length: 348  Bit Score: 344.47  E-value: 1.94e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  11 LRHFLQFKDFSPAEIAYVLERTRIIKDKFK-RYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQL 89
Cdd:PLN02342   45 PKHFLHIDDFDKEEILGLLDRAKEVKALLKsGDRSFQPFKGKSMAMIFTKPSMRTRVSFETGFFLLGGHALYLGPDDIQL 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  90 GRSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDAN 169
Cdd:PLN02342  125 GKREETRDIARVLSRYNDIIMARVFAHQDVLDLAEYSSVPVINGLTDYNHPCQIMADALTIIEHIGRLEGTKVVYVGDGN 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 170 NMSYTWLQAAEMLGFTLHVSTPAGYELDPARI-GAPAAGVLKQF--KDPMQACQGAHLVTTDVWTSMGYEAENEERRAAF 246
Cdd:PLN02342  205 NIVHSWLLLAAVLPFHFVCACPKGYEPDAKTVeKARAAGISKIEitNDPAEAVKGADVVYTDVWASMGQKEEAEKRKKAF 284

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 2517005960 247 ADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:PLN02342  285 QGFQVNEALMKLAGPQAYFMHCLPAERGVEVTDGVMEAPNSIVFPQAENRMHAQNAIMLHQL 346
PRK02102 PRK02102
ornithine carbamoyltransferase; Validated
 12-304 1.19e-107

ornithine carbamoyltransferase; Validated


Pssm-ID: 179366 [Multi-domain]  Cd Length: 331  Bit Score: 316.44  E-value: 1.19e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:PRK02102    8 RSFLKLLDFTPEEIEYLIDLSIELKAAKKAGIEHQYLEGKNIALIFEKTSTRTRCAFEVAAIDLGAHVTYLGPNDSQLGK 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDA-NN 170
Cdd:PRK02102   88 KESIEDTARVLGRMYDGIEYRGFKQEIVEELAKYSGVPVWNGLTDEWHPTQMLADFMTMKEHFGPLKGLKLAYVGDGrNN 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 171 MSYTWLQAAEMLGFTLHVSTPAGYEldparigaPAAGVLKQFK--------------DPMQACQGAHLVTTDVWTSMGYE 236
Cdd:PRK02102  168 MANSLMVGGAKLGMDVRICAPKELW--------PEEELVALAReiaketgakititeDPEEAVKGADVIYTDVWVSMGEE 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 237 AENEERRAAFADWCVDAEMM-AAADPQAVFMHCLPA-----------------HRGEEVTGEVIDGAQSVVWDEAENRLH 298
Cdd:PRK02102  240 DEWEERIKLLKPYQVNMDLMkATGNPDVIFMHCLPAfhdtetkvgkeiaekygLKGLEVTDEVFESKYSIVFDEAENRMH 319


                  ....*.
gi 2517005960 299 VQKALM 304
Cdd:PRK02102  320 TIKAVM 325
putr_carbamoyl TIGR04384
putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase ...
 13-308 6.81e-93

putrescine carbamoyltransferase; Members of this family are putrescine carbamoyltransferase (EC 2.1.3.6). There is some overlapping specificity with ornithine carbamoyltransferase (EC 2.1.3.3). The gene regularly is found next to agmatine deiminase and a carbamate kinase, suggesting a conserved catabolic agmatine deiminase pathway. [Energy metabolism, Amino acids and amines]


Pssm-ID: 275177  Cd Length: 330  Bit Score: 278.84  E-value: 6.81e-93
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  13 HFLQFKDFSPAEIAYVLERTRIIKDKFK-RYEPHMpLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:TIGR04384   1 DFIDTNDFTKEEILDIIDLSLKIKEAIKdGYYPPL-LKNKSLGMIFEQSSTRTRVSFETAMTQLGGHAQYLAPGQIQLGG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRgPiAGK-----TVAWIG 166
Cdd:TIGR04384  80 HESIEDTARVLSRLVDIIMARVDRHETVVELAKYATVPVINGMSDYNHPTQELGDLFTMIEHL-P-AGKkledcKVVFVG 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 167 DANNMSYTWLQAAEMLGFTLHVSTPAGYELDPARIG------APAAGVLKQFKDPMQACQGAHLVTTDVWTSM-GYEAEN 239
Cdd:TIGR04384 158 DATQVCVSLMFICTKMGMDFVHFGPKGYQIPEEWLAiaeancKVSGGSVTVTDDVDEAVKGADFIYTDVWYGLyDQELSE 237

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 240 EERRAAF-ADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:TIGR04384 238 EERMAIFyPKYQVNPELMAKAGPHAKFMHCLPASRGEEVTDEVMDSPQSICFDEAENRLTAIRALLVYFL 307
PRK14805 PRK14805
ornithine carbamoyltransferase; Provisional
 11-311 8.27e-84

ornithine carbamoyltransferase; Provisional


Pssm-ID: 237819 [Multi-domain]  Cd Length: 302  Bit Score: 254.61  E-value: 8.27e-84
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  11 LRHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEphMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLG 90
Cdd:PRK14805    1 MKHLLSIKELTQQQLLDLLALAKTIKANPAEYR--QALAGKSVVMLFEKPSLRTRVSFDIGINKLGGHCLYLDQQNGALG 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  91 RSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANN 170
Cdd:PRK14805   79 KRESVADFAANLSCWADAIVARVFSHSTIEQLAEHGSVPVINALCDLYHPCQALADFLTLAEQFGDVSKVKLAYVGDGNN 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 171 MSYTWLQAAEMLGFTLHVSTPAGYELDP-----ARIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAA 245
Cdd:PRK14805  159 VTHSLMYGAAILGATMTVICPPGHFPDGqivaeAQELAAKSGGKLVLTSDIEAIEGHDAIYTDTWISMGDDTPLAEIKAK 238

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2517005960 246 FADWCVDAEMMAAADPQAvFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMeFLLLGQ 311
Cdd:PRK14805  239 FAPYQVNKALMEKAGATF-VMHCQPAHRGVEITSEVMDGEGSLILQQAENRMHAQNAVL-VTLLSQ 302
PRK03515 PRK03515
ornithine carbamoyltransferase subunit I; Provisional
 12-304 2.58e-80

ornithine carbamoyltransferase subunit I; Provisional


Pssm-ID: 179587 [Multi-domain]  Cd Length: 336  Bit Score: 246.93  E-value: 2.58e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:PRK03515    7 RHFLRLLDFTPAELNSLLQLAAKLKADKKNGKEEQKLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEH--RGPIAGKTVAWIGDA- 168
Cdd:PRK03515   87 KESIKDTARVLGRMYDGIQYRGYGQEIVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEHlpGKAFNEMTLAYAGDAr 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 169 NNMSYTWLQAAEMLGFTLHVSTPAGYELDPA------RIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGyEAEN--E 240
Cdd:PRK03515  167 NNMGNSLLEAAALTGLDLRLVAPKACWPEAAlvtecrALAQKNGGNITLTEDIAEGVKGADFIYTDVWVSMG-EPKEvwA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 241 ERRAAFADWCVDAEMMAAA-DPQAVFMHCLPA------------------HRGEEVTGEVIDGAQSVVWDEAENRLHVQK 301
Cdd:PRK03515  246 ERIALLRPYQVNSKMMQLTgNPQVKFLHCLPAfhddqttlgkkmaeeyglHGGMEVTDEVFESAHSIVFDQAENRLHTIK 325


                  ...
gi 2517005960 302 ALM 304
Cdd:PRK03515  326 AVM 328
PRK04284 PRK04284
ornithine carbamoyltransferase; Provisional
 12-304 1.14e-75

ornithine carbamoyltransferase; Provisional


Pssm-ID: 235269 [Multi-domain]  Cd Length: 332  Bit Score: 235.02  E-value: 1.14e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKD-KFKRYEPHMpLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLG 90
Cdd:PRK04284    7 RSFLTLLDFTPKEIEYLLDLSEDLKRaKYAGIEVQK-LKGKNIALIFEKDSTRTRCAFEVAAYDQGAHVTYLGPTGSQMG 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  91 RSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEH-RGPIAGKTVAWIGD-A 168
Cdd:PRK04284   86 KKESTKDTARVLGGMYDGIEYRGFSQRTVETLAEYSGVPVWNGLTDEDHPTQVLADFLTAKEHlKKPYKDIKFTYVGDgR 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 169 NNMSYTWLQAAEMLGFTLHVSTPAGYELDP------ARIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAEN-EE 241
Cdd:PRK04284  166 NNVANALMQGAAIMGMDFHLVCPKELNPDDellnkcKEIAAETGGKITITDDIDEGVKGSDVIYTDVWVSMGEPDEVwEE 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 242 RRAAFADWCVDAEMM-AAADPQAVFMHCLPA-H----------------RGEEVTGEVIDGAQSVVWDEAENRLHVQKAL 303
Cdd:PRK04284  246 RIKLLKPYQVNKEMMkKTGNPNAIFEHCLPSfHdldtkvgkeifekyglKEMEVTDEVFESKASVVFDEAENRMHTIKAV 325


                  .
gi 2517005960 304 M 304
Cdd:PRK04284  326 M 326
OTCace_N pfam02729
Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;
13-152 5.63e-74

Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain;


Pssm-ID: 460665 [Multi-domain]  Cd Length: 140  Bit Score: 223.84  E-value: 5.63e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  13 HFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGRS 92
Cdd:pfam02729   1 HFLSLEDLSREEIEALLDLAAELKEARKRGKKLPLLKGKTVALLFEEPSTRTRVSFEVAAKRLGGHVIYLSSSDIQLSSG 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  93 EPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIE 152
Cdd:pfam02729  81 ESLADTARVLSRYVDAIVIRHFGHEDLEELAEYASVPVINAGGDHEHPTQALADLLTIRE 140
PRK12562 PRK12562
ornithine carbamoyltransferase subunit F; Provisional
 12-304 7.79e-69

ornithine carbamoyltransferase subunit F; Provisional


Pssm-ID: 105755  Cd Length: 334  Bit Score: 217.62  E-value: 7.79e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLGR 91
Cdd:PRK12562    7 KHFLKLLDFTPAELNSLLQLAAKLKADKKNGKEVARLTGKNIALIFEKDSTRTRCSFEVAAYDQGARVTYLGPSGSQIGH 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  92 SEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEHrgpIAGK-----TVAWIG 166
Cdd:PRK12562   87 KESIKDTARVLGRMYDGIQYRGHGQEVVETLAEYAGVPVWNGLTNEFHPTQLLADLLTMQEH---LPGKafnemTLVYAG 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 167 DA-NNMSYTWLQAAEMLGFTLHVSTPAGYELDPARIGAPAA------GVLKQFKDPMQACQGAHLVTTDVWTSMGYEAEN 239
Cdd:PRK12562  164 DArNNMGNSMLEAAALTGLDLRLVAPQACWPEASLVAECSAlaqkhgGKITLTEDIAAGVKGADFIYTDVWVSMGEPKEK 243

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 240 -EERRAAFADWCVDAEMMAAAD-PQAVFMHCLPA------------------HRGEEVTGEVIDGAQSVVWDEAENRLHV 299
Cdd:PRK12562  244 wAERIALLRGYQVNSKMMALTGnPQVKFLHCLPAfhddqttlgkkmakefglHGGMEVTDEVFESPASIVFDQAENRMHT 323


                  ....*
gi 2517005960 300 QKALM 304
Cdd:PRK12562  324 IKAVM 328
OTCace pfam00185
Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;
161-307 8.85e-63

Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain;


Pssm-ID: 425511 [Multi-domain]  Cd Length: 154  Bit Score: 195.91  E-value: 8.85e-63
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 161 TVAWIGDA-NNMSYTWLQAAEMLGFTLHVSTPAGYELDP-----ARIGAPAAGV-LKQFKDPMQACQGAHLVTTDVWTSM 233
Cdd:pfam00185   1 KIAYVGDGhNNVAHSLIIAAAKLGMDVRLATPKGYPPDPevldkAKKIAEKSGGsIEITDDPAEAVKGADVVYTDVWQSM 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 2517005960 234 GYEAENEERRAAFADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFL 307
Cdd:pfam00185  81 GQEKEREERLKAFKPYQVNEELMKLAKKDAIFMHCLPAHRGEEVTDDVFDGPRSVVFDQAENRLHAQKALLALL 154
PRK01713 PRK01713
ornithine carbamoyltransferase; Provisional
 12-304 1.04e-61

ornithine carbamoyltransferase; Provisional


Pssm-ID: 167263 [Multi-domain]  Cd Length: 334  Bit Score: 199.44  E-value: 1.04e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKD-KFKRYEpHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLG 90
Cdd:PRK01713    8 RHLLSLVNHTEREIKYLLDLSRDLKRaKYAGTE-QQRLKGKNIALIFEKTSTRTRCAFEVAAYDQGAQVTYIDPNSSQIG 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  91 RSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYIEH-RGPIAGKTVAWIGDA- 168
Cdd:PRK01713   87 HKESMKDTARVLGRMYDAIEYRGFKQSIVNELAEYAGVPVFNGLTDEFHPTQMLADVLTMIENcDKPLSEISYVYIGDAr 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 169 NNMSYTWLQAAEMLGFTLHVSTPAGYELDPA------RIGAPAAGVLKQFKDPMQACQGAHLVTTDVWTSMGYEAEN-EE 241
Cdd:PRK01713  167 NNMGNSLLLIGAKLGMDVRICAPKALLPEASlvemceKFAKESGARITVTDDIDKAVKGVDFVHTDVWVSMGEPLETwGE 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 242 RRAAFADWCVDAEMMA-AADPQAVFMHCLPA-HRGE------------------EVTGEVIDGAQSVVWDEAENRLHVQK 301
Cdd:PRK01713  247 RIKLLMPYQVTPELMKrTGNPKVKFMHCLPAfHNSEtkvgrqiaekypelangiEVTEDVFESPMNIAFEQAENRMHTIK 326


                  ...
gi 2517005960 302 ALM 304
Cdd:PRK01713  327 AVM 329
PRK04523 PRK04523
N-acetylornithine carbamoyltransferase; Reviewed
 10-307 3.48e-61

N-acetylornithine carbamoyltransferase; Reviewed


Pssm-ID: 235304 [Multi-domain]  Cd Length: 335  Bit Score: 198.05  E-value: 3.48e-61
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  10 PLRHFLQFKDFSPAEIAYVLERTriikDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINL-TSNDS- 87
Cdd:PRK04523    2 SLKHFLNTQDWSRAELDALLTQA----AAFKRNKLGSALKGKSIALVFFNPSLRTRTSFELGAFQLGGHAVVLqPGKDAw 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  88 ----QLG------RSEPIEDTARVISRMVDIVMIRTF----------EQTRIERFASHSRVPVINgLTNEYHPCQILADI 147
Cdd:PRK04523   78 piefELGavmdgeTEEHIREVARVLSRYVDLIGVRAFpkfvdwskdrQDQVLNSFAKYSTVPVIN-METITHPCQELAHA 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 148 FTYIEHRGPI-AGKTV--AWIGDAN--NMSY--TWLQAAEMLGFTLHVSTP-AGYELDPARIGAPAA------GVLKQFK 213
Cdd:PRK04523  157 LALQEHFGTTlRGKKYvlTWTYHPKplNTAVanSALLIATRLGMDVTLLCPtPDYILDERYMDWAEQnaaesgGSLTVSH 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 214 DPMQACQGAHLVTTDVWTSMG-YEAENEER--RAAFADWCVDAEMMAAADpQAVFMHCLPAHRGEEVTGEVIDGAQSVVW 290
Cdd:PRK04523  237 DIDSAYAGADVVYAKSWGALPfFGNWEPEKpiRDQYQHFIVDERKMALTN-NGVFSHCLPLRRNVKVTDAVMDSPNCIAI 315

                         330
                  ....*....|....*..
gi 2517005960 291 DEAENRLHVQKALMEFL 307
Cdd:PRK04523  316 DEAENRLHVQKAIMAAL 332
PRK14804 PRK14804
ornithine carbamoyltransferase; Provisional
 11-308 3.64e-52

ornithine carbamoyltransferase; Provisional


Pssm-ID: 173265 [Multi-domain]  Cd Length: 311  Bit Score: 174.06  E-value: 3.64e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  11 LRHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPlhDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQLG 90
Cdd:PRK14804    6 VKHLISWEDWSDSEILDLLDFAVHVKKNRVNYAGHMS--GRSLAMLFQKTSTRTRVSFEVAMTEMGGHGIYLDWMASNFQ 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  91 RSEpIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVINGLTNEYHPCQILADIFTYI--EHRGPIAGKTVAWIGDA 168
Cdd:PRK14804   84 LSD-IDLEARYLSRNVSVIMARLKKHEDLLVMKNGSQVPVINGCDNMFHPCQSLADIMTIAldSPEIPLNQKQLTYIGVH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 169 NNMSYTWLQAAEMLGFTLHVSTP--AGYELDPARIG-APAAGVLKQFKDPMQACQGAHLVTTDVWTSM------GYEAEN 239
Cdd:PRK14804  163 NNVVNSLIGITAALGIHLTLVTPiaAKENIHAQTVErAKKKGTLSWEMNLHKAVSHADYVYTDTWLDMeffndpSYADKK 242

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2517005960 240 EERRAAFADWCVDAEMMAAADpqAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLL 308
Cdd:PRK14804  243 KQRMELMMPYQINSSLMEKTN--AKVMHDMPIHAGYEITREVVLSDRSIIFQQAENRLDAQKAVILKLL 309
PyrB COG0540
Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; ...
 8-311 1.08e-50

Aspartate carbamoyltransferase, catalytic subunit [Nucleotide transport and metabolism]; Aspartate carbamoyltransferase, catalytic subunit is part of the Pathway/BioSystem: Pyrimidine biosynthesis


Pssm-ID: 440306 [Multi-domain]  Cd Length: 306  Bit Score: 169.85  E-value: 1.08e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960   8 NGPLRHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDS 87
Cdd:COG0540     2 SFKMRHLLSIEDLSREEIEELLDTAEEFKEVLRPIKKVPLLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSASTS 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  88 QLGRSEPIEDTARVISRM-VDIVMIRTFEQTRIERFASHSRVPVIN---GlTNEyHPCQILADIFTYIEHRGPIAGKTVA 163
Cdd:COG0540    82 SVSKGESLADTIRTLEAYgADAIVIRHPQEGAARLLAEHVDVPVINagdG-AHE-HPTQALLDLYTIREEFGRLDGLKVA 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 164 WIGDANNM----SYTWLQAaeMLGFTLHVSTPAgyELDPARIGapAAGVlKQFKDPMQACQGAhlvttDVWtsmgY---- 235
Cdd:COG0540   160 IVGDLKHSrvarSNIKALS--KLGAEVTLVAPP--TLLPEEIE--ELGV-EVTTDLDEALPDA-----DVV----Ymlri 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 236 ------EAENEERRAAFADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLLL 309
Cdd:COG0540   224 qkerftDGLFPSYREYKRSYGLTAERLALAKPDAIVMHPGPRNRGVEIDSDVDDTPRSVIFEQVTNGVAVRMALLYLLLG 303


                  ..
gi 2517005960 310 GQ 311
Cdd:COG0540   304 GE 305
pyrB PRK00856
aspartate carbamoyltransferase catalytic subunit;
7-311 8.64e-47

aspartate carbamoyltransferase catalytic subunit;


Pssm-ID: 234849 [Multi-domain]  Cd Length: 305  Bit Score: 159.47  E-value: 8.64e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960   7 QNGPLRHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMP-LHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSN 85
Cdd:PRK00856    1 NPLKMKHLLSIEDLSREEIELLLDTAEEFKEVLRREVKKVPlLRGKTVANLFFEPSTRTRLSFELAAKRLGADVINFSAS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  86 DSQLGRSEPIEDTARVISRM-VDIVMIRTFEQTRIERFASHSRVPVIN---GlTNEyHPCQILADIFTYIEHRGPIAGKT 161
Cdd:PRK00856   81 TSSVSKGETLADTIRTLSAMgADAIVIRHPQSGAARLLAESSDVPVINagdG-SHQ-HPTQALLDLLTIREEFGRLEGLK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 162 VAWIGD------AN-NMsytwlQAAEMLGFTLHVSTPAgyELDPAriGAPAAGVlkqFKDPMQACQGAHLVttdvwtsM- 233
Cdd:PRK00856  159 VAIVGDikhsrvARsNI-----QALTRLGAEVRLIAPP--TLLPE--GMPEYGV---HTDLDEVIEDADVV-------Mm 219

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 234 ----------GYEAENEErraAFADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKAL 303
Cdd:PRK00856  220 lrvqkermdgGLLPSYEE---YKRSYGLTAERLALAKPDAIVMHPGPVNRGVEIASDVADGPQSVIFEQVTNGVAVRMAV 296


                  ....*...
gi 2517005960 304 MEFLLLGQ 311
Cdd:PRK00856  297 LELLLGGR 304
asp_carb_tr TIGR00670
aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB ...
 12-309 6.48e-41

aspartate carbamoyltransferase; Aspartate transcarbamylase (ATCase) is an alternate name.PyrB encodes the catalytic chain of aspartate carbamoyltransferase, an enzyme of pyrimidine biosynthesis, which organizes into trimers. In some species, including E. coli and the Archaea but excluding Bacillus subtilis, a regulatory subunit PyrI is also present in an allosterically regulated hexameric holoenzyme. Several molecular weight classes of ATCase are described in MEDLINE:96303527 and often vary within taxa. PyrB and PyrI are fused in Thermotoga maritima.Ornithine carbamoyltransferases are in the same superfamily and form an outgroup. [Purines, pyrimidines, nucleosides, and nucleotides, Pyrimidine ribonucleotide biosynthesis]


Pssm-ID: 273209 [Multi-domain]  Cd Length: 301  Bit Score: 144.42  E-value: 6.48e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  12 RHFLQFKDFSPAEIAYVLERTRIIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLT-SNDSQLG 90
Cdd:TIGR00670   1 RHLISISDLSREEIELLLETARELEQVLNGKEPLKLLKGKILANLFFEPSTRTRLSFETAMKRLGGSVVNFSdSETSSVA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  91 RSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVIN-GLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDAN 169
Cdd:TIGR00670  81 KGETLADTIKTLSGYVDAIVIRHPLEGAARLAAEVSEVPVINaGDGSNQHPTQTLLDLYTIYEEFGRLDGLKIALVGDLK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 170 N--MSYTWLQAAEMLGFTLHVSTPagyeldparigaPAAGVLKQFKDPMQAcQGAHLVTT----------DVWTS----- 232
Cdd:TIGR00670 161 YgrTVHSLAEALTRFGVEVYLISP------------EELRMPKEILEELKA-KGIKVRETesleevideaDVLYVtriqk 227

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 2517005960 233 --MGYEAENEERRAAFadwCVDAEMMAAADPQAVFMHCLPahRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLLL 309
Cdd:TIGR00670 228 erFPDPEEYEKVKGSY---GITLERLEAAKKGVIIMHPLP--RVDEIDPSVDDTPHAKYFKQAFNGVPVRMALLALLLG 301
PLN02527 PLN02527
aspartate carbamoyltransferase
 48-310 1.45e-28

aspartate carbamoyltransferase


Pssm-ID: 178142 [Multi-domain]  Cd Length: 306  Bit Score: 111.76  E-value: 1.45e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  48 LHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTS--NDSQLGRSEPIEDTARVISRMVDIVMIRTFEQTRIERFASH 125
Cdd:PLN02527   37 LKGYLMATLFYEPSTRTRLSFESAMKRLGGEVLTTENagEFSSAAKGETLEDTIRTVEGYSDIIVLRHFESGAARRAAAT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 126 SRVPVIN-GLTNEYHPCQILADIFTYIEHRGPIAGKTVAWIGDANNmSYTWLQAAEML----GFTLHVSTPAGYEL-DPA 199
Cdd:PLN02527  117 AEIPVINaGDGPGQHPTQALLDVYTIQREIGRLDGIKVGLVGDLAN-GRTVRSLAYLLakyeDVKIYFVAPDVVKMkDDI 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 200 RIGAPAAGV-LKQFKDPMQACQGAHLVTTDVWTSMGYEAENEERRAAFADWCVDAEMMAAADPQAVFMHCLPahRGEEVT 278
Cdd:PLN02527  196 KDYLTSKGVeWEESSDLMEVASKCDVLYQTRIQRERFGERIDLYEAARGKYIVDKKVMDVLPKHAVVMHPLP--RLDEIT 273

                         250       260       270
                  ....*....|....*....|....*....|..
gi 2517005960 279 GEVIDGAQSVVWDEAENRLHVQKALMEFLLLG 310
Cdd:PLN02527  274 TDVDSDPRAAYFRQAKNGLFIRMALLKLLLGG 305
PRK11891 PRK11891
aspartate carbamoyltransferase; Provisional
 53-270 1.79e-22

aspartate carbamoyltransferase; Provisional


Pssm-ID: 183362 [Multi-domain]  Cd Length: 429  Bit Score: 96.86  E-value: 1.79e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  53 LAMVFEKASTRTRVSFEAGMYQMGGSVINLTS-NDSQLGRSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVI 131
Cdd:PRK11891  129 LGNLFFEASTRTRVSFGAAFCRLGGSVCDTTGfTFSSMAKGESIYDTSRVMSGYVDALVIRHPEQGSVAEFARATNLPVI 208

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 132 NGLTNE-YHPCQILADIFTyIEHRGPIAGKTV-----AWIGDannMSY--TWLQAAEML----GFTLHVSTPAGYELdPA 199
Cdd:PRK11891  209 NGGDGPgEHPSQALLDLYT-IQREFSRLGKIVdgahiALVGD---LKYgrTVHSLVKLLalyrGLKFTLVSPPTLEM-PA 283

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 2517005960 200 RIGAPAAG---VLKQFKDPMQACQGAHLV-TTDVWTSmgyEAENEERRAAFADWCVDAEMM-AAADPQAVFMHCLP 270
Cdd:PRK11891  284 YIVEQISRnghVIEQTDDLAAGLRGADVVyATRIQKE---RFADESFEGYTPDFQINQALVdAVCKPDTLIMHPLP 356
PRK08192 PRK08192
aspartate carbamoyltransferase; Provisional
 53-167 5.59e-18

aspartate carbamoyltransferase; Provisional


Pssm-ID: 169269 [Multi-domain]  Cd Length: 338  Bit Score: 82.85  E-value: 5.59e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  53 LAMVFEKASTRTRVSFEAGMYQMGGSVINLTS-NDSQLGRSEPIEDTARVISRMVDIVMIRTFEQTRIERFASHSRVPVI 131
Cdd:PRK08192   47 LGNLFFEPSTRTRVSFGCAFNLLGGHVRETTGmASSSLSKGESLYDTARVLSTYSDVIAMRHPDAGSVKEFAEGSRVPVI 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 2517005960 132 NG--LTNEyHPCQILADIFTY---IEHRG-PIAGKTVAWIGD 167
Cdd:PRK08192  127 NGgdGSNE-HPTQALLDLFTIqkeLAHAGrGIDGMHIAMVGD 167
pyrB PRK13814
aspartate carbamoyltransferase;
10-309 1.61e-16

aspartate carbamoyltransferase;


Pssm-ID: 139876 [Multi-domain]  Cd Length: 310  Bit Score: 78.61  E-value: 1.61e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  10 PLrHFLQFKDFSPAEIAYVLERTR-IIKDKFKRYEPHMPLHDRTLAMVFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQ 88
Cdd:PRK13814    5 PL-HLLNMRSLTRDHIEKLIQRANyFLTQGMEKNSVFETLKGHVVANLFFEPSTRTRNSFEIAAKRLGAMVLNPNLKISA 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  89 LGRSEPIEDTARVISRM-VDIVMIRTFEQTRIERFASH-SRVPVIN-GLTNEYHPCQILADIFTYIEHRGPIAGKTVAWI 165
Cdd:PRK13814   84 ISKGETLFDTIKTLEAMgVYFFIVRHSENETPEQIAKQlSSGVVINaGDGNHQHPSQALIDLMTIKQHKPHWNKLCVTII 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 166 GDA--NNMSYTWLQAAEMLGF-TLHVSTPAgyELDPARIGAPAagvLKQFKDPMQAcqgahLVTTDVWTSMGYEAENEER 242
Cdd:PRK13814  164 GDIrhSRVANSLMDGLVTMGVpEIRLVGPS--SLLPDKVGNDS---IKKFTELKPS-----LLNSDVIVTLRLQKERHDN 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 2517005960 243 RA---AF-ADWCVDAEMMAAADPQAVFMHCLPAHRGEEVTGEVIDGAQSVVWDEAENRLHVQKALMEFLLL 309
Cdd:PRK13814  234 SVdidAFrGSFRLTPEKLYSAKPDAIVMHPGPVNREVEINSDVADNQQSVILQQVRNGVAMRMAVLELFLL 304
PRK07200 PRK07200
aspartate/ornithine carbamoyltransferase family protein; Validated
 18-293 1.10e-15

aspartate/ornithine carbamoyltransferase family protein; Validated


Pssm-ID: 235961 [Multi-domain]  Cd Length: 395  Bit Score: 76.70  E-value: 1.10e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  18 KDF------SPAEIAYVLERTRIIKdkFKRYEPHMP-LHDRTLAM-VFEKASTRTRVSFEAGMYQMGGSVINLTSNDSQL 89
Cdd:PRK07200   21 KDFlltwekTPDELKAVLDVADALR--ALREENISTkVFNSGLGIsVFRDNSTRTRFSYASACNLLGLEVQDLDEGKSQI 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  90 GRSEPIEDTARVISRMVDIVMIRT---------------------FEQTRIErfashSRVPVINGLTNEYHPCQILADIF 148
Cdd:PRK07200   99 AHGETVRETANMISFMADVIGIRDdmyigkgnaymrevgaavddgYKQGVLP-----QRPTLVNLQCDIDHPTQSMADLL 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 149 TYIEHRGPI---AGKTVA--WigdANNMSY----TWLQAAEML----GFTLHVSTPAGYELDP-----ARIGAPAAGV-L 209
Cdd:PRK07200  174 HLIEHFGGLenlKGKKIAmtW---AYSPSYgkplSVPQGIIGLmtrfGMDVTLAHPEGYDLMPevvevAKKNAKASGGsF 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960 210 KQFKDPMQACQGAHLVTTDVWTSMGY-------------------EAENEERRAAFADWCVDAEMMA-AADPQAVFMHCL 269
Cdd:PRK07200  251 RQVNSMEEAFKDADIVYPKSWAPYKVmeertelyragdhegikalEKELLAQNAQHKDWHCTEEMMKlTKDGKALYMHCL 330

                         330       340       350
                  ....*....|....*....|....*....|
gi 2517005960 270 PAH------RGEEVTGEVIDGAQSVVWDEA 293
Cdd:PRK07200  331 PADisgvscKEGEVTESVFDRYRIALYKEA 360
pyrB PRK13376
bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase ...
 18-152 8.20e-05

bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional


Pssm-ID: 237369 [Multi-domain]  Cd Length: 525  Bit Score: 43.98  E-value: 8.20e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2517005960  18 KDFSPAEIAYVLERTRIIKDKFKRYEP----HMPLHDRTLAMVFEKASTRTRVSF-EAGMYQMGGSVINLTSNDSQLGRS 92
Cdd:PRK13376   14 EDLSVEEQLFLYEKTRELKQRWYEGEDvsefRIKKRDVGIYIVFVEPSTRTKESFiNAAKFHKNVKVNIFDSEHSSFNKQ 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 2517005960  93 EPIEDTARVISRMVD--IVMIRT-------FEQTRIERFASHSRVPV---INGLTNEY-HPCQILADIFTYIE 152
Cdd:PRK13376   94 ESYTDTFNMLTGYSDysIFIVRTrlegvcrLLEEKVSEFASRNGIEVpafINAGDGKHeHPTQELLDEFTFLE 166
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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