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Conserved domains on  [gi|2447998489|gb|WDR17096|]
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NRG1 class VII isoform alpha beta 2a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PHA02887 super family cl31518
EGF-like protein; Provisional
 56-98 3.06e-03

EGF-like protein; Provisional


The actual alignment was detected with superfamily member PHA02887:

Pssm-ID: 165214  Cd Length: 126  Bit Score: 34.90  E-value: 3.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2447998489  56 KCAEKEKTFCVNGgECFMVKDLSnpsRYLCKCQPGFTGARCTE 98
Cdd:PHA02887   85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
 
Name Accession Description Interval E-value
PHA02887 PHA02887
EGF-like protein; Provisional
 56-98 3.06e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 34.90  E-value: 3.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2447998489  56 KCAEKEKTFCVNGgECFMVKDLSnpsRYLCKCQPGFTGARCTE 98
Cdd:PHA02887   85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 65-95 3.33e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 33.13  E-value: 3.33e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2447998489  65 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 95
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 65-97 3.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 32.99  E-value: 3.62e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2447998489  65 CVNGGECFMVkdlsnPSRYLCKCQPGFTGARCT 97
Cdd:cd00054    11 CQNGGTCVNT-----VGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
PHA02887 PHA02887
EGF-like protein; Provisional
 56-98 3.06e-03

EGF-like protein; Provisional


Pssm-ID: 165214  Cd Length: 126  Bit Score: 34.90  E-value: 3.06e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 2447998489  56 KCAEKEKTFCVNGgECFMVKDLSnpsRYLCKCQPGFTGARCTE 98
Cdd:PHA02887   85 KCKNDFNDFCING-ECMNIIDLD---EKFCICNKGYTGIRCDE 123
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 65-95 3.33e-03

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 33.13  E-value: 3.33e-03
                          10        20        30
                  ....*....|....*....|....*....|.
gi 2447998489  65 CVNGGECFMVkdlsnPSRYLCKCQPGFTGAR 95
Cdd:pfam00008   6 CSNGGTCVDT-----PGGYTCICPEGYTGKR 31
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 65-97 3.62e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 32.99  E-value: 3.62e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 2447998489  65 CVNGGECFMVkdlsnPSRYLCKCQPGFTGARCT 97
Cdd:cd00054    11 CQNGGTCVNT-----VGSYRCSCPPGYTGRNCE 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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