NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1780587500|emb|VYS61635|]
View 

unnamed protein product [Arabidopsis thaliana]

Protein Classification

ETO1 family protein( domain architecture ID 13031935)

ETO1 family protein similar to Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) that is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 181-263 7.47e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


:

Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 130.33  E-value: 7.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSENHVSSSAMRVVRDFSVVGVLIGVSKNLLLEVLVFA 260
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                  ...
gi 1780587500 261 NKF 263
Cdd:cd18190    81 SKF 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-867 3.33e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 3.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYCDR 789
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELdpDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 790 ----ELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKADL-HLLHLRAAFHEHIGDVTSALRDCR 864
Cdd:COG0457    89 lgryEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDaDALYNLGIALEKLGRYEEALELLE 168


                  ...
gi 1780587500 865 AAL 867
Cdd:COG0457   169 KLE 171
PEP_TPR_lipo super family cl37187
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 359-777 8.98e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


The actual alignment was detected with superfamily member TIGR02917:

Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 8.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 359 RSDRTLGFLEKLvdfAENDRQQVLGFHRLGCMRLLRKEYREAEEAFETAFNL--GHVYSATGLARLGYIQGHRLWAYEKL 436
Cdd:TIGR02917 446 QFDKALAAAKKL---EKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIepDFFPAAANLARIDIQEGNPDDAIQRF 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 437 SSVISSVSPPLGWMYQERSFYCEGDKK---LEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILG-FKLALE 512
Cdd:TIGR02917 523 EKVLTIDPKNLRAILALAGLYLRTGNEeeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADaAPDSPE 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 513 CLEIRFCLYLGMDDYEAALRDIQAALTLCPDyrmfdgkvagrQLQTLVyehvenwTTADcwmqLYEKWSNVDdiGSLSVI 592
Cdd:TIGR02917 603 AWLMLGRAQLAAGDLNKAVSSFKKLLALQPD-----------SALALL-------LLAD----AYAVMKNYA--KAITSL 658

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 593 YQMLESDACKGVLYFRQSLLLLRLNCPEAAMRSLQLAREHASSDHERLVYEGWILYDTGHCEEGLQKAKEsigikrsfea 672
Cdd:TIGR02917 659 KRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRK---------- 728

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 673 yFLQAYALAESSLDPSSSSTVVSLLEDALKCPSDRLRK----GQALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAH 746
Cdd:TIGR02917 729 -ALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKThpndAVLRTALAELYLAQKDYDKAIKHYQTVVKKapDNAVVL 807

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1780587500 747 QGLARVhFLRNDKAAAYEEMTRLIEKAQNNA 777
Cdd:TIGR02917 808 NNLAWL-YLELKDPRALEYAERALKLAPNIP 837
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 181-263 7.47e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 130.33  E-value: 7.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSENHVSSSAMRVVRDFSVVGVLIGVSKNLLLEVLVFA 260
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                  ...
gi 1780587500 261 NKF 263
Cdd:cd18190    81 SKF 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-867 3.33e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 3.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYCDR 789
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELdpDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 790 ----ELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKADL-HLLHLRAAFHEHIGDVTSALRDCR 864
Cdd:COG0457    89 lgryEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDaDALYNLGIALEKLGRYEEALELLE 168


                  ...
gi 1780587500 865 AAL 867
Cdd:COG0457   169 KLE 171
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 359-777 8.98e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 8.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 359 RSDRTLGFLEKLvdfAENDRQQVLGFHRLGCMRLLRKEYREAEEAFETAFNL--GHVYSATGLARLGYIQGHRLWAYEKL 436
Cdd:TIGR02917 446 QFDKALAAAKKL---EKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIepDFFPAAANLARIDIQEGNPDDAIQRF 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 437 SSVISSVSPPLGWMYQERSFYCEGDKK---LEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILG-FKLALE 512
Cdd:TIGR02917 523 EKVLTIDPKNLRAILALAGLYLRTGNEeeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADaAPDSPE 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 513 CLEIRFCLYLGMDDYEAALRDIQAALTLCPDyrmfdgkvagrQLQTLVyehvenwTTADcwmqLYEKWSNVDdiGSLSVI 592
Cdd:TIGR02917 603 AWLMLGRAQLAAGDLNKAVSSFKKLLALQPD-----------SALALL-------LLAD----AYAVMKNYA--KAITSL 658

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 593 YQMLESDACKGVLYFRQSLLLLRLNCPEAAMRSLQLAREHASSDHERLVYEGWILYDTGHCEEGLQKAKEsigikrsfea 672
Cdd:TIGR02917 659 KRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRK---------- 728

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 673 yFLQAYALAESSLDPSSSSTVVSLLEDALKCPSDRLRK----GQALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAH 746
Cdd:TIGR02917 729 -ALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKThpndAVLRTALAELYLAQKDYDKAIKHYQTVVKKapDNAVVL 807

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1780587500 747 QGLARVhFLRNDKAAAYEEMTRLIEKAQNNA 777
Cdd:TIGR02917 808 NNLAWL-YLELKDPRALEYAERALKLAPNIP 837
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 181-280 1.53e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 47.30  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500  181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIgVSKNLLLEVLVFA 260
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLD-LPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 1780587500  261 NKFCCERLKDACDRELASLI 280
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
461-578 1.29e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 461 DKKLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLALECLEIRF---CLYLGMDDYEAALRDIQAA 537
Cdd:COG4785    90 DLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRAL--ELDPDYAYAYLnrgIALYYLGRYELAIADLEKA 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1780587500 538 LTLCPDYRMFDGKVAGRQLQTLVYEHVENWTTAdcWMQLYE 578
Cdd:COG4785   168 LELDPNDPERALWLYLAERKLDPEKALALLLED--WATAYL 206
 
Name Accession Description Interval E-value
BTB_POZ_ETO1-like cd18190
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 181-263 7.47e-36

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana ethylene-overproduction protein 1 (ETO1) and similar proteins; ETO1, also called protein ethylene overproducer 1, is an essential regulator of the ethylene pathway, which acts by regulating the stability of 1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes. It may act as a substrate-specific adaptor that connects ACS enzymes, such as ACS5, to ubiquitin ligase complexes, leading to proteasomal degradation of ACS enzymes. The family also includes ETO1-like proteins 1 (EOL1) and 2 (EOL2). ETO1, EOL1, and EOL2 contain a BTB domain and tetratricopeptide (TPR) repeats. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349499 [Multi-domain]  Cd Length: 83  Bit Score: 130.33  E-value: 7.47e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSENHVSSSAMRVVRDFSVVGVLIGVSKNLLLEVLVFA 260
Cdd:cd18190     1 DLVFCVGGEKFCCVRKKIASLSRPFKAMLYGNFRESTSDCIDFEENGISIEAMRAVIDFSVTGRLDLFSVENVHEVLELA 80


                  ...
gi 1780587500 261 NKF 263
Cdd:cd18190    81 SKF 83
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-867 3.33e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 61.56  E-value: 3.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYCDR 789
Cdd:COG0457     9 EAYNNLGLAYRRLGRYEEAIEDYEKALELdpDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLALQA 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 790 ----ELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKADL-HLLHLRAAFHEHIGDVTSALRDCR 864
Cdd:COG0457    89 lgryEEALEDYDKALELDPDDAEALYNLGLALLELGRYDEAIEAYERALELDPDDaDALYNLGIALEKLGRYEEALELLE 168


                  ...
gi 1780587500 865 AAL 867
Cdd:COG0457   169 KLE 171
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 712-879 2.93e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 58.97  E-value: 2.93e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKVRHTR--AHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASA-------YEK 782
Cdd:COG2956    43 EAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRaeALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEAlrllaeiYEQ 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 783 RSEYcdrELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAF-KADLHLLHLRAAFHEHIGDVTSALR 861
Cdd:COG2956   123 EGDW---EKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLdPDCARALLLLAELYLEQGDYEEAIA 199

                         170
                  ....*....|....*...
gi 1780587500 862 DCRAALSVDPNHQEMLEL 879
Cdd:COG2956   200 ALERALEQDPDYLPALPR 217
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
737-877 6.78e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 6.78e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 737 ALKVRHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC----DRELAKSDLEMVTRLDPLRVYPYRY 812
Cdd:COG0457     2 ELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYlrlgRYEEALADYEQALELDPDDAEALNN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1780587500 813 RAAVLMDSRKEREAITELSRAIAFKADLHLLHL-RAAFHEHIGDVTSALRDCRAALSVDPNHQEML 877
Cdd:COG0457    82 LGLALQALGRYEEALEDYDKALELDPDDAEALYnLGLALLELGRYDEAIEAYERALELDPDDADAL 147
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
712-848 8.31e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 57.32  E-value: 8.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC-- 787
Cdd:COG0457    43 EALYNLGLAYLRLGRYEEALADYEQALELdpDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALle 122

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1780587500 788 --DRELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKADLHLLHLRAA 848
Cdd:COG0457   123 lgRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 717-873 1.02e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 57.43  E-value: 1.02e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 717 LGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC----DRE 790
Cdd:COG2956    14 KGLNYLLNGQPDKAIDLLEEALELdpETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYlkagLLD 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 791 LAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFK-ADLHLLHLRAAFHEHIGDVTSALRDCRAALSV 869
Cdd:COG2956    94 RAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGpENAHAYCELAELYLEQGDYDEAIEALEKALKL 173


                  ....
gi 1780587500 870 DPNH 873
Cdd:COG2956   174 DPDC 177
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 654-881 1.73e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 58.08  E-value: 1.73e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 654 EEGLQKAKESIGIKRSFEAYFLQAYALAESSLDPSSSSTVVSLLEDALKCPSDRLRKGQALNNLGSVYVDCEKLDLAADC 733
Cdd:COG3914    21 AAAAELALAAELEAAALAAALGLALLLLAALAEAAAAALLALAAGEAAAAAAALLLLAALLELAALLLQALGRYEEALAL 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 734 YINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYCDR----ELAKSDLEMVTRLDPLRV 807
Cdd:COG3914   101 YRRALALnpDNAEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRlgrlEEAIAALRRALELDPDNA 180

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1780587500 808 YPYRYRAAVLMDSRKEREAITELSRAIAFK---ADLHLLHLRAAFHEHIGDVTSALRDCRAALSVDPNHQEMLELHS 881
Cdd:COG3914   181 EALNNLGNALQDLGRLEEAIAAYRRALELDpdnADAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSPFALLY 257
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 744-873 5.57e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 49.81  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 744 RAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC----DRELAKSDLEMVTRLDPLRVYPYRYRAAVLMD 819
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILlqlgDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1780587500 820 SRKEREAITELSRAIA-FKADLHLLHLRAAFHEHIGDVTSALRDCRAALSVDPNH 873
Cdd:COG4783    85 AGDYDEALALLEKALKlDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 359-777 8.98e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 52.78  E-value: 8.98e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 359 RSDRTLGFLEKLvdfAENDRQQVLGFHRLGCMRLLRKEYREAEEAFETAFNL--GHVYSATGLARLGYIQGHRLWAYEKL 436
Cdd:TIGR02917 446 QFDKALAAAKKL---EKKQPDNASLHNLLGAIYLGKGDLAKAREAFEKALSIepDFFPAAANLARIDIQEGNPDDAIQRF 522

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 437 SSVISSVSPPLGWMYQERSFYCEGDKK---LEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILG-FKLALE 512
Cdd:TIGR02917 523 EKVLTIDPKNLRAILALAGLYLRTGNEeeaVAWLEKAAELNPQEIEPALALAQYYLGKGQLKKALAILNEAADaAPDSPE 602

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 513 CLEIRFCLYLGMDDYEAALRDIQAALTLCPDyrmfdgkvagrQLQTLVyehvenwTTADcwmqLYEKWSNVDdiGSLSVI 592
Cdd:TIGR02917 603 AWLMLGRAQLAAGDLNKAVSSFKKLLALQPD-----------SALALL-------LLAD----AYAVMKNYA--KAITSL 658

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 593 YQMLESDACKGVLYFRQSLLLLRLNCPEAAMRSLQLAREHASSDHERLVYEGWILYDTGHCEEGLQKAKEsigikrsfea 672
Cdd:TIGR02917 659 KRALELKPDNTEAQIGLAQLLLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRK---------- 728

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 673 yFLQAYALAESSLDPSSSSTVVSLLEDALKCPSDRLRK----GQALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAH 746
Cdd:TIGR02917 729 -ALKRAPSSQNAIKLHRALLASGNTAEAVKTLEAWLKThpndAVLRTALAELYLAQKDYDKAIKHYQTVVKKapDNAVVL 807

                         410       420       430
                  ....*....|....*....|....*....|.
gi 1780587500 747 QGLARVhFLRNDKAAAYEEMTRLIEKAQNNA 777
Cdd:TIGR02917 808 NNLAWL-YLELKDPRALEYAERALKLAPNIP 837
BTB smart00225
Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. ...
 181-280 1.53e-06

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.


Pssm-ID: 197585 [Multi-domain]  Cd Length: 97  Bit Score: 47.30  E-value: 1.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500  181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIgVSKNLLLEVLVFA 260
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD--VSPEDFRALLNFLYTGKLD-LPEENVEELLELA 77

                           90       100
                   ....*....|....*....|
gi 1780587500  261 NKFCCERLKDACDRELASLI 280
Cdd:smart00225  78 DYLQIPGLVELCEEFLLKLL 97
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 712-867 1.59e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.50  E-value: 1.59e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKVRHTRAH--QGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC-- 787
Cdd:COG2956   111 EALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHayCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYle 190

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 788 --DRELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKADLHLLHLRAAFHEHIGDVTSALRDCRA 865
Cdd:COG2956   191 qgDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLER 270


                  ..
gi 1780587500 866 AL 867
Cdd:COG2956   271 QL 272
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
606-848 4.02e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 49.23  E-value: 4.02e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 606 YFRQSLLLLRLNCPEAAMRSLQLAREHASSDHERLVYEGWILYDTGHCEEGLQKAKESIGIK-RSFEAYFLQAYALAEss 684
Cdd:COG0457    11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDpDDAEALNNLGLALQA-- 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 685 ldpsssstvVSLLEDALKC--------PSDrlrkGQALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHF 754
Cdd:COG0457    89 ---------LGRYEEALEDydkaleldPDD----AEALYNLGLALLELGRYDEAIEAYERALELdpDDADALYNLGIALE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 755 LRNDKAAAYEemtrLIEKAQNNASAYEKRSEYCDRELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAI 834
Cdd:COG0457   156 KLGRYEEALE----LLEKLEAAALAALLAAALGEAALALAAAEVLLALLLALEQALRKKLAILTLAALAELLLLALALLL 231

                         250
                  ....*....|....
gi 1780587500 835 AFKADLHLLHLRAA 848
Cdd:COG0457   232 ALRLAALALYQYRA 245
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 712-839 5.39e-06

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 46.72  E-value: 5.39e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC-- 787
Cdd:COG4783     5 EALYALAQALLLAGDYDEAEALLEKALELdpDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALlk 84

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1780587500 788 --DRELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKAD 839
Cdd:COG4783    85 agDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPD 138
BTB_POZ_KLHL28_BTBD5 cd18257
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 181-273 1.10e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 28 (KLHL28); KLHL28, also called BTB/POZ domain-containing protein 5 (BTBD5), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349566 [Multi-domain]  Cd Length: 118  Bit Score: 45.61  E-value: 1.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVlIGVSKNLLLEVLVFA 260
Cdd:cd18257    20 DVVLRVGDVKIHAHKVVLASCSPYFKAMFTGNLSEKENSEVEFQC--IDETALQAIVEYAYTGT-VFISQATVESLLPAA 96

                          90       100
                  ....*....|....*....|.
gi 1780587500 261 N--------KFCCERLKDACD 273
Cdd:cd18257    97 NllqiklvlKECCDFLESQLD 117
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
461-578 1.29e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 47.22  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 461 DKKLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLALECLEIRF---CLYLGMDDYEAALRDIQAA 537
Cdd:COG4785    90 DLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRAL--ELDPDYAYAYLnrgIALYYLGRYELAIADLEKA 167

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1780587500 538 LTLCPDYRMFDGKVAGRQLQTLVYEHVENWTTAdcWMQLYE 578
Cdd:COG4785   168 LELDPNDPERALWLYLAERKLDPEKALALLLED--WATAYL 206
BTB_POZ_BTBD9 cd18287
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-271 3.86e-05

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 9 (BTBD9); BTBD9 is a risk factor for Restless Legs Syndrome (RLS) encoding a Cullin-3 substrate adaptor. The BTBD9 gene may be associated with antipsychotic-induced RLS in schizophrenia. Mutations in BTBD9 lead to reduced dopamine, increased locomotion and sleep fragmentation. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349596 [Multi-domain]  Cd Length: 119  Bit Score: 43.76  E-value: 3.86e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 182 VVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVG--VLIGVSKNLLLEVLVF 259
Cdd:cd18287    25 VTFVVEEKRFPAHRVILAARSEYFRALLYGGMRESQQSEIELKD--TNAEAFKALLKYIYTGrlTLTDLKEDVLLDVLGL 102

                          90
                  ....*....|..
gi 1780587500 260 ANKFCCERLKDA 271
Cdd:cd18287   103 AHQYGFEELEAA 114
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
385-544 1.11e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 44.61  E-value: 1.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 385 HRLGCMRLLRKEYREAEEAFETAFNLGHVYsATGLARLGyiqghrlWAYEKLSSVissvspplgwmyqersfycegDKKL 464
Cdd:COG0457    12 NNLGLAYRRLGRYEEAIEDYEKALELDPDD-AEALYNLG-------LAYLRLGRY---------------------EEAL 62

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 465 EDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLALECLEIRF---CLYLGMDDYEAALRDIQAALTLC 541
Cdd:COG0457    63 ADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKAL--ELDPDDAEALYnlgLALLELGRYDEAIEAYERALELD 140


                  ...
gi 1780587500 542 PDY 544
Cdd:COG0457   141 PDD 143
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 712-835 1.38e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 44.72  E-value: 1.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC-- 787
Cdd:COG2956   145 HAYCELAELYLEQGDYDEAIEALEKALKLdpDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYek 224

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1780587500 788 --DRELAKSDLEMVTRLDPLrVYPYRYRAAVLMDSRKEREAITELSRAIA 835
Cdd:COG2956   225 lgDPEEALELLRKALELDPS-DDLLLALADLLERKEGLEAALALLERQLR 273
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
788-875 1.41e-04

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 44.14  E-value: 1.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 788 DRELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFK-ADLHLLHLRAAFHEHIGDVTSALRDCRAA 866
Cdd:COG4785    88 DYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDpDYAYAYLNRGIALYYLGRYELAIADLEKA 167


                  ....*....
gi 1780587500 867 LSVDPNHQE 875
Cdd:COG4785   168 LELDPNDPE 176
BTB_POZ cd01165
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 182-263 1.51e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily; Proteins in this superfamily are characterized by the presence of a common protein-protein interaction motif of about 100 amino acids, known as the BTB/POZ domain. Members include transcription factors, oncogenic proteins, ion channel proteins, and potassium channel tetramerization domain (KCTD) proteins. They have been identified in poxviruses and many eukaryotes, and have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats, among others. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. In ion channel proteins and KCTD proteins, the BTB/POZ domain is also called the tetramerization (T1) domain.


Pssm-ID: 349496 [Multi-domain]  Cd Length: 79  Bit Score: 41.11  E-value: 1.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 182 VVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIGVSKNlLLEVLVFAN 261
Cdd:cd01165     1 VVLVVEGEKFHVNKELLAQSSEYFRALFRGGFRESGQAEINLRD--ISPEDFRALLEFLYGGKRDLDASN-LLELLEAAN 77


                  ..
gi 1780587500 262 KF 263
Cdd:cd01165    78 FL 79
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
375-562 5.10e-04

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 42.69  E-value: 5.10e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 375 ENDRQQVLGFHRLGCMRLLRKEYREAEEAFETAFNLgHVYSATGLARLGYIQGHR------LWAYEK---LSSVISSVSP 445
Cdd:COG0457    36 ELDPDDAEALYNLGLAYLRLGRYEEALADYEQALEL-DPDDAEALNNLGLALQALgryeeaLEDYDKaleLDPDDAEALY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 446 PLGWMYQERSFYcegDKKLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILGFKLALECLEIRFCLYLGMD 525
Cdd:COG0457   115 NLGLALLELGRY---DEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALA 191

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 1780587500 526 DYEAALRDIQAALTLCPDYRMFDGKVAGRQLQTLVYE 562
Cdd:COG0457   192 AAEVLLALLLALEQALRKKLAILTLAALAELLLLALA 228
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 367-544 5.59e-04

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 42.79  E-value: 5.59e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 367 LEKLVDFAENDRQQVLGFHRLGCMRLLRKEYREAEEAFETA-----------FNLGHVYSATGLarlgYIQGHRLwaYEK 435
Cdd:COG2956    28 IDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLlerdpdraealLELAQDYLKAGL----LDRAEEL--LEK 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 436 LSSVISSVS---PPLGWMYQERSfycEGDKKLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLALE 512
Cdd:COG2956   102 LLELDPDDAealRLLAEIYEQEG---DWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL--KLDPD 176

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1780587500 513 CLEIRF---CLYLGMDDYEAALRDIQAALTLCPDY 544
Cdd:COG2956   177 CARALLllaELYLEQGDYEEAIAALERALEQDPDY 211
BTB_POZ_KLHL35 cd18265
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 181-285 7.48e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349574 [Multi-domain]  Cd Length: 128  Bit Score: 40.53  E-value: 7.48e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFsVVGVLIGVSKNLLLEVLVFA 260
Cdd:cd18265    25 DVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQK--VSAAAMEVLLDY-MYGGGLRIQEDNVESVLEAS 101

                          90       100
                  ....*....|....*....|....*
gi 1780587500 261 NKFCCERLKDACDRELASLISSMEC 285
Cdd:cd18265   102 DLLQVSKLREACVRFLEGQLHPCNC 126
BTB_POZ_KLHL18 cd18247
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-272 7.70e-04

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 18 (KLHL18); KLHL18 acts as a substrate-specific adaptor for a Cullin3 E3 ubiquitin-protein ligase complex that regulates mitotic entry and ubiquitylates Aurora-A. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349556 [Multi-domain]  Cd Length: 116  Bit Score: 39.96  E-value: 7.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 182 VVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIGVSKNlLLEVLVFAN 261
Cdd:cd18247    22 VTLKVGDQKFSAHRIVLAATIPYFHAMFTHDMVESKQDEITMQG--IEPSALEALINFAYSGRIAIDTSN-VQSLLVGAS 98

                          90
                  ....*....|.
gi 1780587500 262 KFCCERLKDAC 272
Cdd:cd18247    99 FLQLQSVKDAC 109
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 672-806 8.14e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 8.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 672 AYFLQAYALAESSLDPSSSSTVVSLLEDALKCPSDRLRKGQALNNLGSVYVDCEKLDLAADCYINALKVR--HTRAHQGL 749
Cdd:COG5010    15 LLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDpnNPELYYNL 94

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1780587500 750 ARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC----DRELAKSDLEMVTRLDPLR 806
Cdd:COG5010    95 ALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLlslgQDDEAKAALQRALGTSPLK 155
BTB2_POZ_RhoBTB cd18300
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 182-272 8.71e-04

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349609 [Multi-domain]  Cd Length: 108  Bit Score: 39.53  E-value: 8.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 182 VVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSenHVSSSAMRVVRDFSVVGVLIGVSKNLLLEVLVFAN 261
Cdd:cd18300    12 VTFIVEDGTIPAHKALLVARCDVMAAMFGGNFRESSAKEVELP--GVSKETFLALLEYLYTDQAPILEDGDCVGLIVLAN 89

                          90
                  ....*....|.
gi 1780587500 262 KFCCERLKDAC 272
Cdd:cd18300    90 RLCLPRLVALC 100
BTB2_POZ_RHOBTB1 cd18358
second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain ...
 173-268 1.70e-03

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing protein 1 (RhoBTB1); RhoBTB1 is an atypical Rho family small guanosine triphosphatase (GTPase) and is a member of the RhoBTB subfamily, which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, tandem BTB domains, and a conserved C-terminal region. The carboxyl terminal extension that harbors two BTB domains is capable of assembling cullin 3-dependent ubiquitin ligase complexes. RhoBTB1 functions as a tumor suppressor that regulates the integrity of the Golgi complex through the methyltransferase METTL7B. It also acts an adaptor of the Cullin-3-dependent E3 ubiquitin ligase complex. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349667 [Multi-domain]  Cd Length: 126  Bit Score: 39.18  E-value: 1.70e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 173 KTNR---SVSKN----VVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSenHVSSSAMRVVRDFSVVGVL 245
Cdd:cd18358     7 KANRikeCLSKGtfsdVTFKLDDGTINAHKPLLICSCEWMAAMFGGSFIESANSEVVLP--NISKVSMQAVLDYLYTKQL 84

                          90       100
                  ....*....|....*....|...
gi 1780587500 246 IGVSKNLLLEVLVFANKFCCERL 268
Cdd:cd18358    85 SPTADLDPLELIALANRFCLPHL 107
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 447-543 2.00e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 39.22  E-value: 2.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 447 LGWMYQERSFYcegDKKLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLALECLEIRFCL---YLG 523
Cdd:COG4235    23 LGRAYLRLGRY---DEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERAL--ALDPDNPEALYLLglaAFQ 97

                          90       100
                  ....*....|....*....|
gi 1780587500 524 MDDYEAALRDIQAALTLCPD 543
Cdd:COG4235    98 QGDYAEAIAAWQKLLALLPA 117
BTB_POZ_KLHL8 cd18238
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 182-270 2.05e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349547 [Multi-domain]  Cd Length: 120  Bit Score: 38.81  E-value: 2.05e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 182 VVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIGVSKNL--------L 253
Cdd:cd18238    18 VTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKD--IDEEAVELLVDFAYTGKLTLTVDNVqsllyaasL 95

                          90
                  ....*....|....*..
gi 1780587500 254 LEVLVFAnKFCCERLKD 270
Cdd:cd18238    96 LQVEEVA-KACCEFMKD 111
BTB_POZ_KLHL30 cd18259
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 172-285 2.14e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 30 (KLHL30); KLHL30 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349568 [Multi-domain]  Cd Length: 137  Bit Score: 39.43  E-value: 2.14e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 172 VKTNRSVSK--NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIGVS 249
Cdd:cd18259    23 LQTLRSNPKlsDVTLLVGGREFPCHRSVLALCSHYFNAMFTGDFVESISARVEIKD--VDPAVMESLIDFAYTGKLTINQ 100

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1780587500 250 KNllLEVLVF-ANKFCCERLKDACDRELASLISSMEC 285
Cdd:cd18259   101 GN--VEALIRtSNRLQFPTVRKVCSRYLQQQIDATNC 135
BTB_POZ_KLHL21 cd18250
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 181-285 2.17e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 21 (KLHL21); KLHL21 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of aurora B. KLHL21 also targets IkappaB kinase-beta to regulate nuclear factor kappa-light chain enhancer of activated B cells (NF-kappaB) signaling negatively. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349559 [Multi-domain]  Cd Length: 124  Bit Score: 38.98  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVLIGVSKN--LLLEVlv 258
Cdd:cd18250    23 DVTLCAGGREFPCHRTVLAAASSYFRAMFAGELRESRADRVVLHG--VSAEILGLLLDFSYTGRVTVTQDNveALLRA-- 98

                          90       100
                  ....*....|....*....|....*..
gi 1780587500 259 fANKFCCERLKDACDRELASLISSMEC 285
Cdd:cd18250    99 -ADLFQFPSVKEACCAYLQQRLDVSNC 124
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 361-543 2.32e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.87  E-value: 2.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 361 DRTLGFLEKLVDfAENDRQQVLgfHRLGCMRLLRKEYREAEEAFETAFNLGHvYSATGLARLGYI-QGHRLWA------- 432
Cdd:COG2956    59 DRAIRIHQKLLE-RDPDRAEAL--LELAQDYLKAGLLDRAEELLEKLLELDP-DDAEALRLLAEIyEQEGDWEkaievle 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 433 -YEKLSSVISSVSPPLGWMYQERSfycEGDKKLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLAL 511
Cdd:COG2956   135 rLLKLGPENAHAYCELAELYLEQG---DYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERAL--EQDP 209

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1780587500 512 ECLEIRFCL---YLGMDDYEAALRDIQAALTLCPD 543
Cdd:COG2956   210 DYLPALPRLaelYEKLGDPEEALELLRKALELDPS 244
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
788-872 2.55e-03

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 37.84  E-value: 2.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 788 DRELAKSDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAItELSRAIAFKADL-HLLHLRAAFHEHIGDVTSALRDCRAA 866
Cdd:COG3063     7 DLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNaEALLNLAELLLELGDYDEALAYLERA 85


                  ....*.
gi 1780587500 867 LSVDPN 872
Cdd:COG3063    86 LELDPS 91
BTB_POZ_KLHL7 cd18237
BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in ...
 181-285 2.73e-03

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 7 (KLHL7); KLHL7 is a component of a Cul3-based E3 ubiquitin ligase complex and is involved in the ubiquitination of target proteins for proteasome-mediated degradation. Mutations in KLHL7 causes autosomal-dominant retinitis pigmentosa. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349546 [Multi-domain]  Cd Length: 126  Bit Score: 38.62  E-value: 2.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 181 NVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGvLIGVSKNLLLEVLVFA 260
Cdd:cd18237    23 DVILIVEGREIKAHRVVLAAASHFFHLMFTSNMTESKSSEVELKD--AEPDIIELLVEFAYTA-RISVNSNNVQSLLDAA 99

                          90       100
                  ....*....|....*....|....*
gi 1780587500 261 NKFCCERLKDACDRELASLISSMEC 285
Cdd:cd18237   100 NQYQIEPVKKMCVDFLKEQLDASNC 124
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 727-871 3.27e-03

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 39.17  E-value: 3.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 727 LDLAADCYINALKVRHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYcdrELAKSDLEMVTRLDPLR 806
Cdd:COG5010    11 PLYLLLLTKLRTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDF---EESLALLEQALQLDPNN 87

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1780587500 807 VYPYRYRAAVLMDSRKEREAITELSRAIAFK-ADLHLLHLRAAFHEHIGDVTSALRDCRAALSVDP 871
Cdd:COG5010    88 PELYYNLALLYSRSGDKDEAKEYYEKALALSpDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 711-804 3.53e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.45  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 711 GQALNNLGSVYVDCEKLDLAADCYINALKV--RHTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNN-------ASAYE 781
Cdd:COG4235    17 AEGWLLLGRAYLRLGRYDEALAAYEKALRLdpDNADALLDLAEALLAAGDTEEAEELLERALALDPDNpealyllGLAAF 96

                          90       100
                  ....*....|....*....|...
gi 1780587500 782 KRSEYcdrELAKSDLEMVTRLDP 804
Cdd:COG4235    97 QQGDY---AEAIAAWQKLLALLP 116
BTB_POZ_trishanku-like cd18314
BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in ...
 175-272 3.59e-03

BTB (Broad-Complex, Tramtrack and Bric a brac) /POZ (poxvirus and zinc finger) domain found in Dictyostelium discoideum trishanku and similar proteins; Trishanku is a novel regulator required for normal morphogenesis and cell-type stability in Dictyostelium discoideum. It contains a BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.


Pssm-ID: 349623 [Multi-domain]  Cd Length: 96  Bit Score: 37.71  E-value: 3.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 175 NRSVSKNVVFKIGEEKIACQRRKIASLSAPFHAMLYGNFTESLLDEIDMSEnhVSSSAMRVVRDFSVVGVlIGVSKNLLL 254
Cdd:cd18314     2 NDSEFSDVVLCVGDRKFFAHRIVLCARSPVFRSMLTGSMIESNLKEVTLED--VEPEIFETVLKYMYTGQ-VTLSEENVL 78

                          90
                  ....*....|....*...
gi 1780587500 255 EVLVFANKFCCERLKDAC 272
Cdd:cd18314    79 DLLMLASKYQVPDLEKLC 96
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 742-835 4.75e-03

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 38.06  E-value: 4.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 742 HTRAHQGLARVHFLRNDKAAAYEEMTRLIEKAQNNASAYEKRSEYC----DRELAKSDLEMVTRLDPLRVYPYRYRAAVL 817
Cdd:COG4235    16 DAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALlaagDTEEAEELLERALALDPDNPEALYLLGLAA 95

                          90
                  ....*....|....*...
gi 1780587500 818 MDSRKEREAITELSRAIA 835
Cdd:COG4235    96 FQQGDYAEAIAAWQKLLA 113
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 447-547 6.22e-03

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 40.36  E-value: 6.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 447 LGWMYQERSFYCEGdkkLEDLEKATELDPTLTYPYMYRAVTRMSKQNAKAALEEINRILgfKLALECLEIRFCL---YLG 523
Cdd:COG3914   118 LGNLLLALGRLEEA---LAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRAL--ELDPDNAEALNNLgnaLQD 192

                          90       100
                  ....*....|....*....|....
gi 1780587500 524 MDDYEAALRDIQAALTLCPDYRMF 547
Cdd:COG3914   193 LGRLEEAIAAYRRALELDPDNADA 216
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
712-868 7.24e-03

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 39.13  E-value: 7.24e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 712 QALNNLGSVYVDCEKLDLAADCYINALKvrhtrahqglarvhfLRNDKAAAYEEMTRLIEKAQNNASAYEkrseycdrel 791
Cdd:COG4785    74 QLYYERGVAYDSLGDYDLAIADFDQALE---------------LDPDLAEAYNNRGLAYLLLGDYDAALE---------- 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780587500 792 aksDLEMVTRLDPLRVYPYRYRAAVLMDSRKEREAITELSRAIAFKAD-------LHLLHLRAAF--------------H 850
Cdd:COG4785   129 ---DFDRALELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNdperalwLYLAERKLDPekalallledwataY 205

                         170
                  ....*....|....*...
gi 1780587500 851 EHIGDVTSALRDCRAALS 868
Cdd:COG4785   206 LLQGDTEEARELFKLALA 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH