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Conserved domains on  [gi|1780598839|emb|VYS53753|]
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unnamed protein product [Arabidopsis thaliana]

Protein Classification

nodulin-like protein( domain architecture ID 13723588)

nodulin-like protein similar to Arabidopsis thaliana protein nuclear fusion defective 4, which is required for karyogamy during female gametophyte development

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Nodulin-like pfam06813
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.
 17-262 4.86e-121

Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.


:

Pssm-ID: 284279  Cd Length: 250  Bit Score: 357.42  E-value: 4.86e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  17 RWFMVFASFLIMACAGATYLFGTYSKDIKSTLGYDQTTLNLLGFFKDLGANVGVLSGLIAEVTPTWFVLTIGSAMNFVGY 96
Cdd:pfam06813   1 RWLVLVAAIWIQSIAGANYDFSAYSSALKSSLGYSQVQLNLLGVAKDLGKNFGWLSGLASEYLPPWVVLLVGAAMGLVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  97 FMIWLTVTGKVAKPKVWQMCLYICIGANSQNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLYFAIYGHDSK 176
Cdd:pfam06813  81 GVQWLVVTGRIPGLPYWLMFLCICLAGNSICWFNTASLVTCIRNFPESRGVVLGLLKGYAGLSGAIYTQLYTAIYGSDAK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 177 SLILLIAWLPAAVSLVFVYLIREK----KVVRQRNELSVFYQFLYISIFLALFLMAMNIAEKQVHFSKAAYAASATICCA 252
Cdd:pfam06813 161 SLLLLNALVPLVVSLVALYFVRPCppspSVGERRSEDRVFLVLNVISVLLAVYLLVMSILSKFSDLSSARIYASAAILVL 240

                         250
                  ....*....|
gi 1780598839 253 LLFVPLTVSV 262
Cdd:pfam06813 241 LLLVPLAVPI 250
UhpC super family cl34453
Sugar phosphate permease [Carbohydrate transport and metabolism];
336-544 4.37e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG2271:

Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.26  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCGLGSSLTAVDNLGQI-GESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKYKLprplMMTLVLLL 414
Cdd:COG2271   182 FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL----VLAIGLLL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 415 SCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYILNVrVTGMLYDKEAl 493
Cdd:COG2271   258 AALALLLLALlPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL-LVGYLLDATG- 335

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1780598839 494 kqltargltrkdvkdltclgsqcYKLPFLILAAVTFFGALVSLGLAIRTRE 544
Cdd:COG2271   336 -----------------------YQAAFLLLAALALLAALLALLLLRETRK 363
 
Name Accession Description Interval E-value
Nodulin-like pfam06813
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.
 17-262 4.86e-121

Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.


Pssm-ID: 284279  Cd Length: 250  Bit Score: 357.42  E-value: 4.86e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  17 RWFMVFASFLIMACAGATYLFGTYSKDIKSTLGYDQTTLNLLGFFKDLGANVGVLSGLIAEVTPTWFVLTIGSAMNFVGY 96
Cdd:pfam06813   1 RWLVLVAAIWIQSIAGANYDFSAYSSALKSSLGYSQVQLNLLGVAKDLGKNFGWLSGLASEYLPPWVVLLVGAAMGLVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  97 FMIWLTVTGKVAKPKVWQMCLYICIGANSQNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLYFAIYGHDSK 176
Cdd:pfam06813  81 GVQWLVVTGRIPGLPYWLMFLCICLAGNSICWFNTASLVTCIRNFPESRGVVLGLLKGYAGLSGAIYTQLYTAIYGSDAK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 177 SLILLIAWLPAAVSLVFVYLIREK----KVVRQRNELSVFYQFLYISIFLALFLMAMNIAEKQVHFSKAAYAASATICCA 252
Cdd:pfam06813 161 SLLLLNALVPLVVSLVALYFVRPCppspSVGERRSEDRVFLVLNVISVLLAVYLLVMSILSKFSDLSSARIYASAAILVL 240

                         250
                  ....*....|
gi 1780598839 253 LLFVPLTVSV 262
Cdd:pfam06813 241 LLLVPLAVPI 250
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 16-532 8.82e-117

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 351.55  E-value: 8.82e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  16 GRWFMVFASFLIMACAGATYLFGTYSKDIKSTLGYDQTTLNLLGFFKDLGANVGVLSGLIAEVTPTWFVLTIGSAMNFVG 95
Cdd:cd17354     1 LRWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  96 YFMIWLTVTGKVAKPKVWQMCLYICIGANSQNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLYFAIYGHDS 175
Cdd:cd17354    81 YGVLWLVVTGLISDLSFWLMCLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQLYKALFFHDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 176 KSLILLIAWLPAAVSLVFVYLIREKKVVRQrnelsvfyqflyisiflalflmamniaekqvhfskaayaasaticcallf 255
Cdd:cd17354   161 ARVFLFLAVLPAVVGLLAWFSVRIVSIEEG-------------------------------------------------- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 256 vpltvsvkqelevwnmmklpieepsevkvekpkkeldldqdkaakvngeeketkscfstvfsppprgedytilQALLSTD 335
Cdd:cd17354   191 -------------------------------------------------------------------------EFLKDID 197

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCGLGSSLTAVDNLGQIGESLGyPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKYKLPRPLMMTLVLLLS 415
Cdd:cd17354   198 FWLLFISLFLGVGPGEMFINNLGQIGQSLT-GPSNTSTLVSLFSIFSFLGRLLSGLLSDLFVRKFRLPRPSRMVLLLLIL 276

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 416 CAGHLLIAFPVP-GSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYILNVRVTGMLYDkealk 494
Cdd:cd17354   277 SLGHLLQAFGLPsGALYVASALIGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYD----- 351

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1780598839 495 qltaRGLTRKDVKDLTCLGSQCYKLPFLILAAVTFFGA 532
Cdd:cd17354   352 ----NGGEGAGSDDLSCIGPHCFSLTFLIMAAVCLLAV 385
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
336-544 4.37e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.26  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCGLGSSLTAVDNLGQI-GESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKYKLprplMMTLVLLL 414
Cdd:COG2271   182 FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL----VLAIGLLL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 415 SCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYILNVrVTGMLYDKEAl 493
Cdd:COG2271   258 AALALLLLALlPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL-LVGYLLDATG- 335

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1780598839 494 kqltargltrkdvkdltclgsqcYKLPFLILAAVTFFGALVSLGLAIRTRE 544
Cdd:COG2271   336 -----------------------YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 318-489 6.05e-08

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 54.97  E-value: 6.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 318 PPPRGEDYTILQALLSTDMIILFVA-TFCGLGSSLTAVdNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyl 396
Cdd:cd17355   194 ASPASPGSTLKEALRSASFWLLALAfFLCGFAVVGLIV-HLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD-- 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 397 lakyKLPRPLMMTLVLLLSCAG--HLLIAFPVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFN----CGQL 470
Cdd:cd17355   271 ----RYSPRRLLAASYALRALGlaLLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGlvfaPHQL 346

                         170
                  ....*....|....*....
gi 1780598839 471 ASPLGSYilnvrVTGMLYD 489
Cdd:cd17355   347 GSALGPW-----LGGLLYD 360
MFS_1 pfam07690
Major Facilitator Superfamily;
338-479 1.90e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 338 ILFVATFCGLGSSLTAVDNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPRPLMMTLVLLLSCA 417
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD------RFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 418 GHLLIAFPVP-GSVYIASILMGFSFGAQLPLLFAIISELFGLK-------YYSTLFNCGQLASPLGSYIL 479
Cdd:pfam07690  75 GLLLLLFASSlWLLLVLRVLQGLGAGALFPAALALIADWFPPEergralgLVSAGFGLGAALGPLLGGLL 144
 
Name Accession Description Interval E-value
Nodulin-like pfam06813
Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.
 17-262 4.86e-121

Nodulin-like; This family represents a conserved region within plant nodulin-like proteins.


Pssm-ID: 284279  Cd Length: 250  Bit Score: 357.42  E-value: 4.86e-121
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  17 RWFMVFASFLIMACAGATYLFGTYSKDIKSTLGYDQTTLNLLGFFKDLGANVGVLSGLIAEVTPTWFVLTIGSAMNFVGY 96
Cdd:pfam06813   1 RWLVLVAAIWIQSIAGANYDFSAYSSALKSSLGYSQVQLNLLGVAKDLGKNFGWLSGLASEYLPPWVVLLVGAAMGLVGY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  97 FMIWLTVTGKVAKPKVWQMCLYICIGANSQNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLYFAIYGHDSK 176
Cdd:pfam06813  81 GVQWLVVTGRIPGLPYWLMFLCICLAGNSICWFNTASLVTCIRNFPESRGVVLGLLKGYAGLSGAIYTQLYTAIYGSDAK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 177 SLILLIAWLPAAVSLVFVYLIREK----KVVRQRNELSVFYQFLYISIFLALFLMAMNIAEKQVHFSKAAYAASATICCA 252
Cdd:pfam06813 161 SLLLLNALVPLVVSLVALYFVRPCppspSVGERRSEDRVFLVLNVISVLLAVYLLVMSILSKFSDLSSARIYASAAILVL 240

                         250
                  ....*....|
gi 1780598839 253 LLFVPLTVSV 262
Cdd:pfam06813 241 LLLVPLAVPI 250
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 16-532 8.82e-117

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 351.55  E-value: 8.82e-117
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  16 GRWFMVFASFLIMACAGATYLFGTYSKDIKSTLGYDQTTLNLLGFFKDLGANVGVLSGLIAEVTPTWFVLTIGSAMNFVG 95
Cdd:cd17354     1 LRWLSFVAALWSQLSAGSIYLFSLYSPPLKSTLGYSQQQNNLLSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  96 YFMIWLTVTGKVAKPKVWQMCLYICIGANSQNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLYFAIYGHDS 175
Cdd:cd17354    81 YGVLWLVVTGLISDLSFWLMCLCFFLIGNSTSSLYTAALVTCAKNFPESRGLAIGIPKGCYGLSGAIGSQLYKALFFHDS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 176 KSLILLIAWLPAAVSLVFVYLIREKKVVRQrnelsvfyqflyisiflalflmamniaekqvhfskaayaasaticcallf 255
Cdd:cd17354   161 ARVFLFLAVLPAVVGLLAWFSVRIVSIEEG-------------------------------------------------- 190

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 256 vpltvsvkqelevwnmmklpieepsevkvekpkkeldldqdkaakvngeeketkscfstvfsppprgedytilQALLSTD 335
Cdd:cd17354   191 -------------------------------------------------------------------------EFLKDID 197

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCGLGSSLTAVDNLGQIGESLGyPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKYKLPRPLMMTLVLLLS 415
Cdd:cd17354   198 FWLLFISLFLGVGPGEMFINNLGQIGQSLT-GPSNTSTLVSLFSIFSFLGRLLSGLLSDLFVRKFRLPRPSRMVLLLLIL 276

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 416 CAGHLLIAFPVP-GSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYILNVRVTGMLYDkealk 494
Cdd:cd17354   277 SLGHLLQAFGLPsGALYVASALIGFGYGGLFSIAPTIVSELFGLKNFGTNYGFLMLAPAIGSLIFSVIYAGVYYD----- 351

                         490       500       510
                  ....*....|....*....|....*....|....*...
gi 1780598839 495 qltaRGLTRKDVKDLTCLGSQCYKLPFLILAAVTFFGA 532
Cdd:cd17354   352 ----NGGEGAGSDDLSCIGPHCFSLTFLIMAAVCLLAV 385
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 17-465 1.96e-13

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 72.26  E-value: 1.96e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  17 RWFMVFASFLIMACAGATYLFGTYSKDIKSTLGYDQTTLNLLG--FFKDLGANVGVLSGLIAEVTPTWfVLTIGSAMNFV 94
Cdd:cd17353     2 RWLVLLGAVLMHLILGYQYAWSVFNPPLSSALGWSLASVALAFtlTIVFLAISAPFAGRLVDRGGPRK-AILIGGILFGL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  95 GYFmiwltVTGKVAKPKVWQMCLYICIGANSqNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLyfaiyghd 174
Cdd:cd17353    81 GFI-----LSAFAISLPLLFLGYGVLGGIGA-GIGYITPVSTAVKWFPDKRGLATGIVIAGFGLGSLIFSPL-------- 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 175 skslilliawlpaavslvFVYLIrekkvvrqrNELSVFYQFLYISIFLALFLMAmniaekqvhfskaayaasaticCALL 254
Cdd:cd17353   147 ------------------IAYLI---------NTVGVPTTFLILGIIFLIIIVI----------------------GAFL 177

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 255 FvpltvsvkqelevwnmmKLPIEepsevkvekpkkeldLDQDKAAKVNGEEKEtkscfstvfsppPRGEDYTILQALLST 334
Cdd:cd17353   178 I-----------------RDPPK---------------GWVPPGVDPLANNAE------------NSPRDYTPREMLRTP 213

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 335 DMIILFVATFCGLGSSLTAVDNLGQIGESL-GYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPRPLMMTLVLL 413
Cdd:cd17353   214 TFWLLWLMFFLNATAGLMLIGQAKPIGQEFaGLDAGIAALAVSILSIFNGGGRPFWGWLSD------KIGRKNTLSIAFL 287

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1780598839 414 LSCAGHLLIAF--PVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLF 465
Cdd:cd17353   288 IQGVAMFLLPFigSVAVLFVLGVALIGFCYGGGFALFPALTADFFGTKNAGTNY 341
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
336-544 4.37e-08

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 55.26  E-value: 4.37e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCGLGSSLTAVDNLGQI-GESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKYKLprplMMTLVLLL 414
Cdd:COG2271   182 FWLLALAYFLVYFALYGFLTWLPTYlVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKL----VLAIGLLL 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 415 SCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYILNVrVTGMLYDKEAl 493
Cdd:COG2271   258 AALALLLLALlPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPL-LVGYLLDATG- 335

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1780598839 494 kqltargltrkdvkdltclgsqcYKLPFLILAAVTFFGALVSLGLAIRTRE 544
Cdd:COG2271   336 -----------------------YQAAFLLLAALALLAALLALLLLRETRK 363
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 318-489 6.05e-08

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 54.97  E-value: 6.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 318 PPPRGEDYTILQALLSTDMIILFVA-TFCGLGSSLTAVdNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyl 396
Cdd:cd17355   194 ASPASPGSTLKEALRSASFWLLALAfFLCGFAVVGLIV-HLVPYLADRGISPAAAAVALALIGLFNIVGRLLSGWLGD-- 270

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 397 lakyKLPRPLMMTLVLLLSCAG--HLLIAFPVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFN----CGQL 470
Cdd:cd17355   271 ----RYSPRRLLAASYALRALGlaLLLLLPFPPLALLLFAALFGLGWGATVPLTAALAARYFGARSYGTLFGlvfaPHQL 346

                         170
                  ....*....|....*....
gi 1780598839 471 ASPLGSYilnvrVTGMLYD 489
Cdd:cd17355   347 GSALGPW-----LGGLLYD 360
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
326-543 2.25e-06

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 50.26  E-value: 2.25e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 326 TILQALLSTDMIILFVATFCGLGSSLTAVDNLGQIG-ESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllaKYKLPR 404
Cdd:COG2223   197 DQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLvDQFGLSAATAGLLAALFALLGALGRPLGGWLSD----RIGGRR 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 405 PLMMTLVLLLSCAGHLLIAFPVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYILNVrVT 484
Cdd:COG2223   273 VLLIVFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPL-LF 351

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1780598839 485 GMLYDKealkqltargltrkdvkdltcLGSqcYKLPFLILAAVTFFGALVSLGLAIRTR 543
Cdd:COG2223   352 GALLDA---------------------TGS--YTAAFLVFAVLALVALVLTLLLYRRPR 387
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
341-457 1.34e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 1.34e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 341 VATFCGLGSSL--TAVDNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFvseyLLAKYKLPRPLMMtLVLLLSCAG 418
Cdd:COG2807   220 LTLFFGLQSLLyyAVVAWLPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPL----LADRLGDRRPLLL-LLGLLGLAG 294

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1780598839 419 HLLIAFPVPGSVYIASILMGFSFGAQLPLLFAIISELFG 457
Cdd:COG2807   295 LLGLLLAPGSLPWLWAVLLGLGQGGLFPLALTLIGLRAR 333
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 338-478 2.35e-05

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 47.02  E-value: 2.35e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 338 ILFVATFCGLGSSLTAVDNLGQIGESLGYPNHTVSS-FVSLVSIWNYFGRVFSGFVSEYLLAKYKlprplmmTLVLLLSC 416
Cdd:cd17314   210 ILFIAIFLVLIGGFLFIANMASLVRSLQLDAPSFVTkLMSIYGLFNAFGRLLWGIVADFFGGRLS-------TLSILLTI 282

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1780598839 417 AGHLLIAFPVPGS-----VYIASILMGFSFGAQLPLLFAIISELFGLKY----YSTLFNCGQLASPLGSYI 478
Cdd:cd17314   283 LGLGLCAFLFLLKmtpvgLVLTGSLLGFSYGGLFTVYPATVSTVFGTESfatlYGILLFAPAIGSILGPML 353
MFS_SLC37A4 cd17343
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ...
 339-443 7.59e-05

Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340901 [Multi-domain]  Cd Length: 409  Bit Score: 45.40  E-value: 7.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 339 LFVATFCGLGSSL--TAVDNLGQ--IGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKYKL-----PR-PLMM 408
Cdd:cd17343   218 LWLLSLGYLVVFGvkTAVTDWGQlfLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHGSssrgnPRmPLAL 297

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1780598839 409 TLVLLLSCAGHLLIAFPVPGSVYIASILMGFSFGA 443
Cdd:cd17343   298 VFMAGLTVSLHLFRVHITSDSSELFILLLGFLIGF 332
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
326-457 1.50e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 1.50e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 326 TILQALLSTDMIILFVATFCGLGSSLTAVDNLGQIG-ESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPR 404
Cdd:COG2814   199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLqEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD------RFGR 272

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1780598839 405 PLMMTLVLLLSCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELFG 457
Cdd:COG2814   273 RRLLLIGLLLLALGLLLLALaGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326
MFS_1 pfam07690
Major Facilitator Superfamily;
338-479 1.90e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.90e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 338 ILFVATFCGLGSSLTAVDNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPRPLMMTLVLLLSCA 417
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSD------RFGRRRVLLIGLLLFAL 74

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 418 GHLLIAFPVP-GSVYIASILMGFSFGAQLPLLFAIISELFGLK-------YYSTLFNCGQLASPLGSYIL 479
Cdd:pfam07690  75 GLLLLLFASSlWLLLVLRVLQGLGAGALFPAALALIADWFPPEergralgLVSAGFGLGAALGPLLGGLL 144
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
336-479 2.11e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 43.81  E-value: 2.11e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFC-GLGSSLTAVdNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPRPLMMTLVLLL 414
Cdd:COG2814    12 LLALALGAFLsGLGIGIVLP-ALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD------RFGRRRVLLLGLLL 84

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1780598839 415 SCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELFGLK-------YYSTLFNCGQLASPLGSYIL 479
Cdd:COG2814    85 FALGSLLCALaPSLWLLLAARFLQGLGAGALFPAALALIADLVPPErrgralgLLGAGLGLGPALGPLLGGLL 157
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 327-478 3.12e-04

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 43.31  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 327 ILQALLSTDMIILFVATFCGLGSSLTAVDNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllaKYKLPRPL 406
Cdd:cd17352   176 LLRLLKDPTFVLLALGVSFAMLGFFVPFVYLPSYAKSLGIDESDAAFLLSIIGISDIVGRILLGLLAD----KPRIGRLY 251

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1780598839 407 MMTLVLLLSCAGHLLIAFPVPGSVYIA-SILMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYI 478
Cdd:cd17352   252 LYIFTLLILGLSLLAFPLATTYVGLIVfSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALV 324
MFS_MCT_like cd17314
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ...
 17-232 5.46e-04

Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340872 [Multi-domain]  Cd Length: 385  Bit Score: 42.40  E-value: 5.46e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  17 RWFMVFASFLIMA-CAGATYLFGTYSKDIKSTLGYDQTTLNLLG-FFKDLGANVGVLSGLIAEVTPTWFVLTIGSAMNFV 94
Cdd:cd17314     1 RWFVLYVSFLLSAmSTGFILSWSLFYQPWQDAFGYSSSQIATAAsLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839  95 GYfmiwlTVTGKVAKPKVWQMCLYICIGAnSQNFANTGALVTCVKNFPESRGVMLGLLKGYVGLSGAIFTQLYFAIYGHD 174
Cdd:cd17314    81 GY-----TYLSYVFNSFPLSYACFVFIGA-GTGILYGSAVLVTTQYFPDTKGLALGLPTTGYSLGLVLGSPLLRILWVFY 154

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1780598839 175 SKSLILLIAWLPAAVSLVFVYLIREKKVVRQRNELSVFYQF---------------LYISIFLAL---FLMAMNIA 232
Cdd:cd17314   155 GLALVYTILGILAAIVLSVVSLLGFKEPPDNQARLHVQKKKtqtmgeifrdkvfwiLFIAIFLVLiggFLFIANMA 230
MFS_MCT11_13 cd17423
Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; ...
 361-457 7.35e-04

Monocarboxylate transporters 11 and 13 of the Major Facilitator Superfamily of transporters; Monocarboxylate transporters 11 (MCT11) and 13 (MCT13) are also called Solute carrier family 16 members 11 (SLC16A11) and 13 (SLC16A13), respectively. They are orphan transporters whose substrates are yet to be determined. MCT11 is expressed in skin, lung, ovary, breast, lung, pancreas, retinal pigment epithelium, and choroid plexus. Genetic variants in SLC16A11, the gene encoding MCT11, are associated with type 2 diabetes in Mexican and other Latin American populations. MCT13 is expressed in breast and bone marrow stem cells. MCT11/13 belongs to the Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340981 [Multi-domain]  Cd Length: 383  Bit Score: 41.99  E-value: 7.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 361 GESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPRPLMMTLVLLLSCAGHLLIAFPV---PGSVYIASILM 437
Cdd:cd17423   232 ARALGLGEYQAAFVVSVAAVADAVGRLFSGWLAD------LGPLRLLHLLVLWTALTGLSLLLLPLakvYGSLLALAVAY 305

                          90       100
                  ....*....|....*....|
gi 1780598839 438 GFSFGAQLPLLFAIISELFG 457
Cdd:cd17423   306 GFCAGALAPLVFSVLPELVG 325
MFS_1 pfam07690
Major Facilitator Superfamily;
328-476 1.03e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 328 LQALLSTDMIILFVATFCGLGSSLTAVDNLGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAKyklPRPLM 407
Cdd:pfam07690 194 WKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR---RRLLL 270

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1780598839 408 MTLVLLLSCAGHLLIAFPV-PGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLF----NCGQLASPLGS 476
Cdd:pfam07690 271 ALLLLILAALGLLLLSLTLsSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASglynTAGSLGGALGP 344
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 388-474 1.96e-03

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 40.63  E-value: 1.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 388 FSGFVSEYLLAKYK--LPRPLMMTLVLLLSCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELF-------G 457
Cdd:cd17473   244 LAGAIGALLFGRLKrrLGKRRLLAIGFALMALGFLLLALaSGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVppelrgrA 323

                          90
                  ....*....|....*..
gi 1780598839 458 LKYYSTLFNCGQLASPL 474
Cdd:cd17473   324 MGIVTSAFFLGQFLSPL 340
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 336-456 5.08e-03

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 39.45  E-value: 5.08e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCgLGSSLTAVDN-LGQIGESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEyllakyKLPRPLMMTLVLLL 414
Cdd:cd17324     1 LLALALAAFA-IGTTEYVIQGlLPDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSD------RIERRRLLLVLLLL 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1780598839 415 SCAGHLLIAF-PVPGSVYIASILMGFSFGAQLPLLFAIISELF 456
Cdd:cd17324    74 FILGNLLAALaPSFALLLLARALAGLAHGGFWAIAAAYAADLV 116
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
357-478 5.33e-03

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 39.47  E-value: 5.33e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 357 LGQIGESLGYPNHTVSSFVSlvsiWNYFGRVFSGFVSEYLLAKYklPRPLMMTLVLLLSCAGHLLIAF-PVPGSVYIASI 435
Cdd:COG2271    33 APPLQADLGLSAAQLGLLAS----AFFLGYALGQIPAGLLADRF--GRRRVLAIGLLLWGLATLLFGFaTSFWQLLLLRF 106

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|...
gi 1780598839 436 LMGFSFGAQLPLLFAIISELFGLKYYSTLFNCGQLASPLGSYI 478
Cdd:COG2271   107 LLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGAL 149
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 336-465 9.00e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 38.56  E-value: 9.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1780598839 336 MIILFVATFCGLGSSLTAVDNLGQIG-ESLGYPNHTVSSFVSLVSIWNYFGRVFSGFVSEYLLAkyklPRPLMMTLVLLL 414
Cdd:cd06174   205 LWLLLLAIFLVNLAYYSFSTLLPLFLlDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIG----RKPLLLIGLLLM 280

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1780598839 415 SCAGHLLIAFPVPGSVYIASILMGFSFGAQLPLLFAIISELFGLKYYSTLF 465
Cdd:cd06174   281 ALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAF 331
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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