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Conserved domains on  [gi|1737948057|emb|VVJ41962|]
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DNA gyrase subunit A [Klebsiella quasivariicola]

Protein Classification

DNA gyrase subunit A( domain architecture ID 11481075)

DNA gyrase subunit A (GyrA) forms a 2:2 heterotetrameric complex with GyrB to form gyrase, a type II topoisomerase that negatively supercoils closed circular double-stranded DNA in an ATP-dependent manner to maintain chromosomes in an underwound state

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
7-842 0e+00

DNA gyrase subunit A; Validated


:

Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 1603.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   7 EITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVY 86
Cdd:PRK05560    4 RIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  87 DTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNL 166
Cdd:PRK05560   84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 167 LVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARA 246
Cdd:PRK05560  164 LVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 247 EVEVDakSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQL 326
Cdd:PRK05560  244 EIEEI--KGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 327 QVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEA 406
Cdd:PRK05560  322 QTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVIALIRASPTPAEA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 407 KAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIA 486
Cdd:PRK05560  402 KEGLME----------------------------------RFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIA 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 487 ELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKG 566
Cdd:PRK05560  448 DLKDILASPERLLEIIKEELLEIKEKFGDPRRTEIIEGEGDIDDEDLIPEEDVVVTLTHGGYIKRTPLDEYRAQRRGGKG 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 567 KSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNV 646
Cdd:PRK05560  528 VSGAKTKEDDFVEHLFVASTHDTLLFFTNRGRVYRLKVYEIPEASRTARGRPIVNLLPLEPGEKITAILPVREFDDDKYL 607
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 647 FMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKL 726
Cdd:PRK05560  608 FFATKNGTVKKTSLSEFSNIRSNGIIAINLDEGDELIGVRLTDGDDDILLATKNGKAIRFPESDVRPMGRTARGVRGIKL 687
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 727 AENDSVVSLIIPRGEGA-ILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLV 805
Cdd:PRK05560  688 REGDEVVSMDVVREDSQeILTVTENGYGKRTPVSEYRLQGRGGKGVITIKITEKNGKLVGALPVDDDDEIMLITDSGKLI 767
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 1737948057 806 RTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEP 842
Cdd:PRK05560  768 RTRVSEISITGRNTQGVRLIRLDEGDKVVSVARVAEE 804
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
7-842 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 1603.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   7 EITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVY 86
Cdd:PRK05560    4 RIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  87 DTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNL 166
Cdd:PRK05560   84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 167 LVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARA 246
Cdd:PRK05560  164 LVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 247 EVEVDakSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQL 326
Cdd:PRK05560  244 EIEEI--KGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 327 QVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEA 406
Cdd:PRK05560  322 QTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVIALIRASPTPAEA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 407 KAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIA 486
Cdd:PRK05560  402 KEGLME----------------------------------RFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIA 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 487 ELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKG 566
Cdd:PRK05560  448 DLKDILASPERLLEIIKEELLEIKEKFGDPRRTEIIEGEGDIDDEDLIPEEDVVVTLTHGGYIKRTPLDEYRAQRRGGKG 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 567 KSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNV 646
Cdd:PRK05560  528 VSGAKTKEDDFVEHLFVASTHDTLLFFTNRGRVYRLKVYEIPEASRTARGRPIVNLLPLEPGEKITAILPVREFDDDKYL 607
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 647 FMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKL 726
Cdd:PRK05560  608 FFATKNGTVKKTSLSEFSNIRSNGIIAINLDEGDELIGVRLTDGDDDILLATKNGKAIRFPESDVRPMGRTARGVRGIKL 687
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 727 AENDSVVSLIIPRGEGA-ILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLV 805
Cdd:PRK05560  688 REGDEVVSMDVVREDSQeILTVTENGYGKRTPVSEYRLQGRGGKGVITIKITEKNGKLVGALPVDDDDEIMLITDSGKLI 767
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 1737948057 806 RTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEP 842
Cdd:PRK05560  768 RTRVSEISITGRNTQGVRLIRLDEGDKVVSVARVAEE 804
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-836 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 1486.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   1 MSDL--AREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYH 78
Cdd:COG0188     1 MSDPppAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  79 PHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDV 158
Cdd:COG0188    81 PHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 159 MPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRG 238
Cdd:COG0188   161 LPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 239 KVYIRARAEVEvDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLN 318
Cdd:COG0188   241 SIRVRAKAEIE-ELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 319 NLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIR 398
Cdd:COG0188   320 QLYKHTQLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIR 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 399 RAPTPAEAKAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEY 478
Cdd:COG0188   400 ASKDPDEAKEALME----------------------------------RFGLSEIQAEAILDMRLRRLTGLEREKIEDEY 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 479 KELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYE 558
Cdd:COG0188   446 AELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERRTEIEEAEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYR 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 559 AQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVR 638
Cdd:COG0188   526 AQRRGGKGVSGMGTKEEDFVEHLFVASTHDTLLFFTNKGRVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVK 605
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 639 EYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTA 718
Cdd:COG0188   606 EFDEDKYLLFATKKGTVKKTPLSDFSNIRKNGIIAINLKEGDELVGVALTDGDDDVLLATSNGKAIRFPESDVRPMGRTA 685
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 719 TGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMI 798
Cdd:COG0188   686 RGVRGIRLKEGDEVVGMAVVDEEDDLLTVTENGYGKRTPLSEYRLQGRGGKGVITIKLTEKNGKLVGALVVNDDDELMLI 765
                         810       820       830
                  ....*....|....*....|....*....|....*...
gi 1737948057 799 TDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGL 836
Cdd:COG0188   766 TSSGQLIRTPVSDIRVTGRNTQGVRLIRLDEGDKVVSV 803
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
8-841 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 1400.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   8 ITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYD 87
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  88 TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLL 167
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 168 VNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAE 247
Cdd:TIGR01063 161 VNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 248 VEVDAKsGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQ 327
Cdd:TIGR01063 241 IEEDSK-GREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQ 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 328 VSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAK 407
Cdd:TIGR01063 320 VSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVIALIRASQNTEEAK 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 408 AGLVAQawdlgnvaamleragddaarpewlepefgvrdgkYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAE 487
Cdd:TIGR01063 400 TRLVER----------------------------------FSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIAD 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 488 LLHILGSADRLMEVIREELELIRDQFGDERRTEITAN-SADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKG 566
Cdd:TIGR01063 446 LEDILASEERVLEIIREELEEIKEQFGDPRRTEIVYDeSEDIDIEDLIARENVVVTLSHNGYVKRVPVSAYRLQKRGGKG 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 567 KSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNV 646
Cdd:TIGR01063 526 VSGADMKDDDFIEQLLVASTHDYLLFFTNRGKVYWLKVYQIPEASRTAKGKPIVNLLPLQPDERITAILSVKEFDDGLYL 605
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 647 FMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKL 726
Cdd:TIGR01063 606 FFATKNGVVKKTSLTEFSNIRSNGIIAIKLDDGDELISVRLTSGEDEVMLGSKNGKAVRFPEEDVRPMGRAARGVRGIKL 685
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 727 AENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVR 806
Cdd:TIGR01063 686 KNEDFVVSLLVVSEESYLLIVTENGYGKRTSIEEYRETSRGGKGVKSIKITDRNGQVVGAIAVDDDDELMLITSAGKLIR 765
                         810       820       830
                  ....*....|....*....|....*....|....*
gi 1737948057 807 TRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAE 841
Cdd:TIGR01063 766 TSVQDVSEQGRNTQGVRLIRLDEDDKLVSVSKVAK 800
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
30-507 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 718.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  30 VGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNF 109
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 110 GSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTE 189
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 190 VINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDakSGRETIIVHEIPYQVN 269
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDD--EGRNTIEITELPYQVN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 270 KARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHH-GQPKIMNLK 348
Cdd:cd00187   239 KAKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPnGRPKKLNLK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 349 DIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAptpAEAKAGLVAQAWdlgnvaamlerag 428
Cdd:cd00187   319 EILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSS---DEAKKALIEELE------------- 382
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1737948057 429 ddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELE 507
Cdd:cd00187   383 ------------------KLGFSEIQADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELD 443
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
11-499 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 661.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   11 VNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIV 90
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   91 RMAQPFSLRYMLVDGQGNFGSI-DGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVN 169
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  170 GASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINgrrgieeayrtGRGKVYIRARAEVE 249
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIV-----------GPGKYVVRGKIEIE 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  250 vdaksGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDES-DKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQV 328
Cdd:smart00434 230 -----DDNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQT 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  329 SFGINMVALH-HGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKAR-DRAHILEALAVALANIDPIIELIRRAPTPA-E 405
Cdd:smart00434 305 TFSINMLALFdNGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEIIVLIRSSKDLAkE 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  406 AKAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQI 485
Cdd:smart00434 385 AKEKLME----------------------------------RFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEI 430
                          490
                   ....*....|....
gi 1737948057  486 AELLHILGSADRLM 499
Cdd:smart00434 431 EDLEKILASEEWLN 444
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
32-507 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 620.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  32 RALPDVRDGLKPVHRRVLYAMNVLGNDwNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGS 111
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFELLNL-DKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 112 -IDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEV 190
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 191 INGCLAYVDDEDISIegLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVdaksgRETIIVHEIPYQVNK 270
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED-----RKTIVITELPYGVWT 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 271 ARLIEKIAELVKEKRVEGISALRDESDKdGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDI 350
Cdd:pfam00521 233 SDLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 351 IAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKAGLVAQawdlgnvaamleragdd 430
Cdd:pfam00521 312 LKEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDRKKAKKNLIEE----------------- 374
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1737948057 431 aarpewlepefgvrdgkyyLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELE 507
Cdd:pfam00521 375 -------------------LSEIQADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
 
Name Accession Description Interval E-value
PRK05560 PRK05560
DNA gyrase subunit A; Validated
7-842 0e+00

DNA gyrase subunit A; Validated


Pssm-ID: 235502 [Multi-domain]  Cd Length: 805  Bit Score: 1603.15  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   7 EITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVY 86
Cdd:PRK05560    4 RIIPVNIEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMNELGNTPDKPYKKSARIVGDVMGKYHPHGDSAVY 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  87 DTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNL 166
Cdd:PRK05560   84 DALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARMSKIAHELLADIDKETVDFVPNYDGSEQEPTVLPARFPNL 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 167 LVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARA 246
Cdd:PRK05560  164 LVNGSSGIAVGMATNIPPHNLGEVIDACLALIDNPDITIEELMEIIPGPDFPTGGIILGRSGIREAYRTGRGSIVMRAKA 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 247 EVEVDakSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQL 326
Cdd:PRK05560  244 EIEEI--KGREAIIVTEIPYQVNKARLIEKIAELVKEKKIEGISDLRDESDRDGMRIVIELKRDAVPEVVLNNLYKHTQL 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 327 QVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEA 406
Cdd:PRK05560  322 QTSFGINMLALVDGQPKLLNLKEILEAFLEHRKEVITRRTRFELRKAEERAHILEGLLIALDNIDEVIALIRASPTPAEA 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 407 KAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIA 486
Cdd:PRK05560  402 KEGLME----------------------------------RFGLSEIQAQAILDMRLQRLTGLERDKIEDEYKELLALIA 447
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 487 ELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKG 566
Cdd:PRK05560  448 DLKDILASPERLLEIIKEELLEIKEKFGDPRRTEIIEGEGDIDDEDLIPEEDVVVTLTHGGYIKRTPLDEYRAQRRGGKG 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 567 KSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNV 646
Cdd:PRK05560  528 VSGAKTKEDDFVEHLFVASTHDTLLFFTNRGRVYRLKVYEIPEASRTARGRPIVNLLPLEPGEKITAILPVREFDDDKYL 607
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 647 FMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKL 726
Cdd:PRK05560  608 FFATKNGTVKKTSLSEFSNIRSNGIIAINLDEGDELIGVRLTDGDDDILLATKNGKAIRFPESDVRPMGRTARGVRGIKL 687
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 727 AENDSVVSLIIPRGEGA-ILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLV 805
Cdd:PRK05560  688 REGDEVVSMDVVREDSQeILTVTENGYGKRTPVSEYRLQGRGGKGVITIKITEKNGKLVGALPVDDDDEIMLITDSGKLI 767
                         810       820       830
                  ....*....|....*....|....*....|....*..
gi 1737948057 806 RTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAEP 842
Cdd:PRK05560  768 RTRVSEISITGRNTQGVRLIRLDEGDKVVSVARVAEE 804
GyrA COG0188
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
1-836 0e+00

DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];


Pssm-ID: 439958 [Multi-domain]  Cd Length: 804  Bit Score: 1486.83  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   1 MSDL--AREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYH 78
Cdd:COG0188     1 MSDPppAERIIPVNLEDEMKRSYLDYAMSVIVGRALPDVRDGLKPVHRRILYAMHELGLTPDKPYKKSARVVGDVMGKYH 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  79 PHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDV 158
Cdd:COG0188    81 PHGDSAVYDALVRMAQDFSMRYPLVDGQGNFGSIDGDPAAAMRYTEARLAKIAEELLADIDKDTVDFVPNYDGSEQEPTV 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 159 MPTKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRG 238
Cdd:COG0188   161 LPARFPNLLVNGSSGIAVGMATNIPPHNLGEVIDACIALIDNPDATIEELMEYIPGPDFPTGGIIVGREGIREAYETGRG 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 239 KVYIRARAEVEvDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLN 318
Cdd:COG0188   241 SIRVRAKAEIE-ELKRGREQIVVTEIPYQVNKARLIEKIAELVKEKKIEGISDVRDESDRDGMRIVIELKRDANPEVVLN 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 319 NLYSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIR 398
Cdd:COG0188   320 QLYKHTQLQTSFGINMLALVDGRPRVLNLKEILEAFLDHRREVVTRRTQFELRKAEERAHILEGLLIALDNIDEVIAIIR 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 399 RAPTPAEAKAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEY 478
Cdd:COG0188   400 ASKDPDEAKEALME----------------------------------RFGLSEIQAEAILDMRLRRLTGLEREKIEDEY 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 479 KELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYE 558
Cdd:COG0188   446 AELLKEIAELEDILASEERLLKIIKEELLEIKKKYGDERRTEIEEAEGEIDIEDLIPDEDVVVTLSHKGYIKRTPLDTYR 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 559 AQRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVR 638
Cdd:COG0188   526 AQRRGGKGVSGMGTKEEDFVEHLFVASTHDTLLFFTNKGRVYRLKVYELPEGSRTAKGKPIVNLLPLEPGEKITAVLPVK 605
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 639 EYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTA 718
Cdd:COG0188   606 EFDEDKYLLFATKKGTVKKTPLSDFSNIRKNGIIAINLKEGDELVGVALTDGDDDVLLATSNGKAIRFPESDVRPMGRTA 685
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 719 TGVRGIKLAENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMI 798
Cdd:COG0188   686 RGVRGIRLKEGDEVVGMAVVDEEDDLLTVTENGYGKRTPLSEYRLQGRGGKGVITIKLTEKNGKLVGALVVNDDDELMLI 765
                         810       820       830
                  ....*....|....*....|....*....|....*...
gi 1737948057 799 TDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGL 836
Cdd:COG0188   766 TSSGQLIRTPVSDIRVTGRNTQGVRLIRLDEGDKVVSV 803
gyrA TIGR01063
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ...
8-841 0e+00

DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273423 [Multi-domain]  Cd Length: 800  Bit Score: 1400.90  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   8 ITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYD 87
Cdd:TIGR01063   1 IVPVNIEEEMKRSYLDYAMSVIVSRALPDVRDGLKPVHRRILYAMYELGLTPDKPYKKSARIVGDVMGKYHPHGDSAIYD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  88 TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLL 167
Cdd:TIGR01063  81 TLVRMAQDFSLRYPLVDGQGNFGSIDGDPPAAMRYTEARLTKIAEELLRDIDKETVDFVPNYDGSEQEPTVLPSRFPNLL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 168 VNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAE 247
Cdd:TIGR01063 161 VNGSSGIAVGMATNIPPHNLGEIIDALLAYIDNPDISIQELLEVIKGPDFPTGGIILGRSGIRSAYETGRGSIVIRARAE 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 248 VEVDAKsGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQ 327
Cdd:TIGR01063 241 IEEDSK-GREAIIVTEIPYQVNKARLIEKIAELVREKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQ 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 328 VSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAK 407
Cdd:TIGR01063 320 VSFGINMLALVKGLPKVLNLKELLEAFVEHRKDVITRRTIFELRKAEERAHILEGLLIALDNIDEVIALIRASQNTEEAK 399
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 408 AGLVAQawdlgnvaamleragddaarpewlepefgvrdgkYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAE 487
Cdd:TIGR01063 400 TRLVER----------------------------------FSLSEIQAQAILDMRLQRLTGLEREKLQEEYKELLELIAD 445
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 488 LLHILGSADRLMEVIREELELIRDQFGDERRTEITAN-SADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKG 566
Cdd:TIGR01063 446 LEDILASEERVLEIIREELEEIKEQFGDPRRTEIVYDeSEDIDIEDLIARENVVVTLSHNGYVKRVPVSAYRLQKRGGKG 525
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 567 KSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYEEGVNV 646
Cdd:TIGR01063 526 VSGADMKDDDFIEQLLVASTHDYLLFFTNRGKVYWLKVYQIPEASRTAKGKPIVNLLPLQPDERITAILSVKEFDDGLYL 605
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 647 FMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKL 726
Cdd:TIGR01063 606 FFATKNGVVKKTSLTEFSNIRSNGIIAIKLDDGDELISVRLTSGEDEVMLGSKNGKAVRFPEEDVRPMGRAARGVRGIKL 685
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 727 AENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTERNGSVVGAVQVDDCDQIMMITDAGTLVR 806
Cdd:TIGR01063 686 KNEDFVVSLLVVSEESYLLIVTENGYGKRTSIEEYRETSRGGKGVKSIKITDRNGQVVGAIAVDDDDELMLITSAGKLIR 765
                         810       820       830
                  ....*....|....*....|....*....|....*
gi 1737948057 807 TRVSEVSIVGRNTQGVILIRTAEDENVVGLQRVAE 841
Cdd:TIGR01063 766 TSVQDVSEQGRNTQGVRLIRLDEDDKLVSVSKVAK 800
PRK05561 PRK05561
DNA topoisomerase 4 subunit A;
1-771 0e+00

DNA topoisomerase 4 subunit A;


Pssm-ID: 235503 [Multi-domain]  Cd Length: 742  Bit Score: 850.17  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   1 MSDLAREITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPH 80
Cdd:PRK05561    3 DMSMLEGIEDLPLEEFLEERYLRYAMYVIMDRALPDVRDGLKPVQRRILYAMSELGLTPDAKFKKSARVVGDVLGKYHPH 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  81 GDSAVYDTIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMP 160
Cdd:PRK05561   83 GDSSIYDAMVRMAQDFSYRYPLVDGQGNFGSIDGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFVPNFDGTLKEPTVLP 162
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 161 TKIPNLLVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPT-AAIINGRRGIEEAYRTGRGK 239
Cdd:PRK05561  163 ARFPNLLLNGATGIAVGMATDIPPHNLREVIDAAIHLIDNPDATLEELMEFVPGPDFPTgGEIITGRDGIRKAYETGRGS 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 240 VYIRARAEVEvDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDG-MRIVIEVKRDAVG-EVVL 317
Cdd:PRK05561  243 IRVRARWEIE-DLAGGRWQIVITELPYQVSKAKLIEQIAELMNAKKLPGIADVRDESDRENpVRIVIEPKSNRVDpEALM 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 318 NNLYSQTQLQVSFGINMVALH-HGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIEL 396
Cdd:PRK05561  322 NHLFATTDLESSYRVNMNAIGlDGRPRVKGLKEILSEWLDHRREVVTRRSQFRLDKVEKRLHILEGLLIAFLNIDEVIRI 401
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 397 IRrapTPAEAKAGLVAqawdlgnvaamleragddaarpewlepEFGvrdgkyyLTEQQAQAILDLRLQKLTGLEHEKLLD 476
Cdd:PRK05561  402 IR---ESDEPKANLMA---------------------------RFD-------LSEIQAEAILELRLRRLAKLEEIEIRK 444
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 477 EYKELLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITANSAD--INIEDLINQEDVVVTLSHQGYVKyqpl 554
Cdd:PRK05561  445 EQDELRKEIAELEAILASERKLRKLIKKELKADAKKFGDPRRTPIEEAEEAiaIDEEALIPDEPVTVVLSKKGWVR---- 520
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 555 tdyeaqRRGGKGKSAA--RIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEAsRGArGRPIVNLLPLEADERIT 632
Cdd:PRK05561  521 ------RAKGHSIDASglSFKEGDSLLFAFEARTTDKLLLFTSTGRVYSLPVHELPSA-RGD-GEPLTGLVDLAPGEEIV 592
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 633 AILPvreYEEGVNVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVR 712
Cdd:PRK05561  593 HVLA---FDPDQKLLLASSAGYGFVVTLEDLVARTRAGKAVINLKDGDEVLPPVPVEDDDHLAAITSNGRLLVFPLSELP 669
                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1737948057 713 AMGRtATGVRGIKL-AENDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPT--KSRATQGV 771
Cdd:PRK05561  670 ELGK-GKGVKLINLpKDDDGLVDLRVLNPEDGLVLLTAGKRKLKLKPSELEKyrGKRARRGR 730
TOP4c cd00187
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ...
30-507 0e+00

DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.


Pssm-ID: 238111 [Multi-domain]  Cd Length: 445  Bit Score: 718.96  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  30 VGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNF 109
Cdd:cd00187     1 NGRALPDVRDGLKPVQRRILYAMFKRGLTPDKPEKKVARLVGDVAGKYHPHGDSSLYDTIVRMAQDFSNNIPLLDPQGNF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 110 GSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTE 189
Cdd:cd00187    81 GSRDGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFVPNYDGQEVEPEVLPPIFPNLLVNGSSGIAVGMATNIPPHNLRE 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 190 VINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDakSGRETIIVHEIPYQVN 269
Cdd:cd00187   161 VIDALRALIDNPEASIDELMEIIKGPDFPTGGIIEGRAGIREAYETGRGRYIIRGKYEIEDD--EGRNTIEITELPYQVN 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 270 KARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHH-GQPKIMNLK 348
Cdd:cd00187   239 KAKLKEKIAELVKDKKIEGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGINMVAFDPnGRPKKLNLK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 349 DIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAptpAEAKAGLVAQAWdlgnvaamlerag 428
Cdd:cd00187   319 EILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNIDEVINLIRSS---DEAKKALIEELE------------- 382
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1737948057 429 ddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELE 507
Cdd:cd00187   383 ------------------KLGFSEIQADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEKILASEERPKDLWKEELD 443
TOP4c smart00434
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
11-499 0e+00

DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC


Pssm-ID: 214660 [Multi-domain]  Cd Length: 444  Bit Score: 661.57  E-value: 0e+00
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   11 VNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIV 90
Cdd:smart00434   1 IDIEDFINKEYLDYSMSVINGRAIPDVRDGLKPVQRRILYAMFKRGLTPDEPKVKSARGVGDVMGKYHPHGDSSLYDTIV 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   91 RMAQPFSLRYMLVDGQGNFGSI-DGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVN 169
Cdd:smart00434  81 RMAQDFSNNYPLLDGQGNFGSRlDGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFVPNYDGQEIEPTVLPPIIPNLLVN 160
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  170 GASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINgrrgieeayrtGRGKVYIRARAEVE 249
Cdd:smart00434 161 GSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDASIDELMMIPWGPDFPTGGEIV-----------GPGKYVVRGKIEIE 229
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  250 vdaksGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDES-DKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQV 328
Cdd:smart00434 230 -----DDNTIVITELPYQVNTADLIEKIAELVKDKKIEGIIDVRDEShDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQT 304
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  329 SFGINMVALH-HGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKAR-DRAHILEALAVALANIDPIIELIRRAPTPA-E 405
Cdd:smart00434 305 TFSINMLALFdNGRPKKYNLKEILKEFLDHRLEVYTRRKEYLLGKLEaERLHILEGLFIALSIIDEIIVLIRSSKDLAkE 384
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  406 AKAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQI 485
Cdd:smart00434 385 AKEKLME----------------------------------RFELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEI 430
                          490
                   ....*....|....
gi 1737948057  486 AELLHILGSADRLM 499
Cdd:smart00434 431 EDLEKILASEEWLN 444
PRK13979 PRK13979
DNA topoisomerase IV subunit A; Provisional
8-802 0e+00

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 237576 [Multi-domain]  Cd Length: 957  Bit Score: 644.85  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   8 ITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYD 87
Cdd:PRK13979   13 IIKIPLEEAMPENYLPYAVEVAKDRALPDVRDGLKPVHRRILYGAYMLKAFPDKPYYKSARIVGDILGKYHPHGDSSVYD 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  88 TIVRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLL 167
Cdd:PRK13979   93 AMVILAQDFTTRMPLIDGHGNWGSIDGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMVDNYSDSEKEPEVLPARYPNLL 172
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 168 VNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAE 247
Cdd:PRK13979  173 VNGAFGIAVGLATNIPPHNLKEVIDGTLAYIDNNEITTKELMNYIKGPDLPTGGILIGKKSLLSAYETGEGKVTLRAKTK 252
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 248 VEvDAKSGRETIIVHEIPYQVNKARLIEKIAELVKEKR----VEGISALRDESDKDGMRIVIEVKRDA---VGEVVLNNL 320
Cdd:PRK13979  253 IE-KLENGRLGIVITEFPYRRNKAKLLQTISEMTADKKhskaLENISDIRDESDRNGIRAVIEFKKSAdedVAEKVLKYL 331
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 321 YSQTQLQVSFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRA 400
Cdd:PRK13979  332 YKKTDLQCNISFNMVALADGKPETMGLKTMLKHYVEHQKEVVTRRTKKELEIAEKRFHIVEGFIKAIGIMDEIIKTIRSS 411
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 401 PTPAEAKAGLVAqawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKE 480
Cdd:PRK13979  412 KSKKDASENLIE----------------------------------KFGFTDEQAEAILELMLYRLTGLEIVAFEKEYKE 457
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 481 LLEQIAELLHILGSADRLMEVIREELELIRDQFGDERRTEITA--NSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYe 558
Cdd:PRK13979  458 LEKLIKKLTKILSSEKELLKVIKKELKEVKEKYGDERRTSIIEddEKAKIDVEELIVVEDVVITLSNEGFIKRIPLKSY- 536
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 559 aqRRGGKGKSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPE---ASRGARGRPIVNLLPLEaDERITAIL 635
Cdd:PRK13979  537 --NRSNSNVEDIEYREGDFNKFLIQSNTKDTLLIFTDKGNMYQIKGINIPEfkwKEKGERLDEIIKGIDLE-SEKIIEAY 613
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 636 PVREYEEGVNVFMATASGTVKKTALTEFSRPRSAgIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKV-VRF--KEDAVR 712
Cdd:PRK13979  614 SIEDFTPQKDFIFITDSGGIKKTSLDKFVTNYTK-LMALKLKKGEKLIKVKLVDRTREEKFIKIKTKKgLSFtvEEPELE 692
                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 713 AMGRTATGVRGIKLAENDSVVSL-IIPRGEGAILTVTQNGYGKrtaaaeyptksratqgvisIKVTERNGSVVGAVQVDD 791
Cdd:PRK13979  693 PVDRNIIGYQLFDLLPNDSIKKVdFCDNYEYKEFYVNINKKGI-------------------IKISDKDNKSSISVFTNS 753
                         810
                  ....*....|.
gi 1737948057 792 CDQIMMITDAG 802
Cdd:PRK13979  754 SKNLLIFSDEG 764
parC_Gpos TIGR01061
DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II ...
13-779 0e+00

DNA topoisomerase IV, A subunit, Gram-positive; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273422 [Multi-domain]  Cd Length: 738  Bit Score: 629.53  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  13 IEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRM 92
Cdd:TIGR01061   6 LEEVFGESFGKYAKYIIQDRALPDIRDGLKPVQRRILYAMFQDGNTFDKPYKKSARTVGEIMGKYHPHGDSSIYDAMVRM 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  93 AQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGAS 172
Cdd:TIGR01061  86 SQDWKNNWTLVEMHGNNGSIDGDNAAAMRYTEARLSLIASELLKDIDKKTVSFIPNFDDSEKEPTVLPALFPNLLINGAT 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 173 GIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVDa 252
Cdd:TIGR01061 166 GIAAGYATNIPPHNLNEVIDALIYRIDHPNCSVDKLMEIVKGPDFPTGGIIQGEDGISKAYETGKGKFIIRAKIEIEVN- 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 253 KSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGI 332
Cdd:TIGR01061 245 KNGLNQIVITEIPYETNKANIVKKIEEIIFDNKVAGIEEVRDESDRNGIRIIIELKKDANAEKILNFLFKHTDLQINYNF 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 333 NMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKAGLVA 412
Cdd:TIGR01061 325 NMVAIANRTPIQVGLLSYLDAYIKHCHEVIINRSKYELEKASKRLEIVEGLIKAISIIDEIIKLIRSSEDKSDAKENLID 404
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 413 qawdlgnvaamleragddaarpewlepefgvrdgKYYLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHIL 492
Cdd:TIGR01061 405 ----------------------------------NFKFTENQAEAIVSLRLYRLTNTDIFELKEEQNELEKKIISLEQII 450
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 493 GSADRLMEVIREELELIRDQFGDERRTEI--TANSADINIEDLINQEDVVVTLSHQGYVKYQPLTDYEAQRRGGKGKsaa 570
Cdd:TIGR01061 451 ASEKARNKLLKKQLEEYKKQFAQQRRSQIedFINQIKINESELIENEDYYVLITKAGYIKRTSNRSFASSKYTDFGS--- 527
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 571 riKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNLLPLEADERITAILPVREYE-EGVNVFMA 649
Cdd:TIGR01061 528 --KDDDILFAQTIANTTDQILIFTSLGNIINIPVHKLADIRWKDLGEHLSNKITFDENETIVFVGTMNEFDvDQPILVLA 605
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 650 TASGTVKKTALTEFS-RPRSAGIIAVNLNEGDELIGVDLTSGQDEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAE 728
Cdd:TIGR01061 606 SKLGMVKRIELTELNiKRNSKATLCIKLKDKDHLISAFLQQKDKLICLVSDLGYALVFHTNEIPVVGAKAAGVKGMKLKE 685
                         730       740       750       760       770
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1737948057 729 NDSVVSLIIPRGEGAILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTER 779
Cdd:TIGR01061 686 DDQVKSGVIFEANESLVLLTQRGSVKRLSISELVVTSRAATGKKLLPLKKK 736
DNA_topoisoIV pfam00521
DNA gyrase/topoisomerase IV, subunit A;
32-507 0e+00

DNA gyrase/topoisomerase IV, subunit A;


Pssm-ID: 459843 [Multi-domain]  Cd Length: 432  Bit Score: 620.72  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  32 RALPDVRDGLKPVHRRVLYAMNVLGNDwNKAYKKSARVVGDVIGKYHPHGDSAVYDTIVRMAQPFSLRYMLVDGQGNFGS 111
Cdd:pfam00521   1 RAIPDVRDGLKPVQRRILYAMFELLNL-DKPYKKVARLVGDVMGKYHPHGDASLYDAIVRMAQDFVGNIPLLDGQGNFGS 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 112 -IDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAVGMATNIPPHNLTEV 190
Cdd:pfam00521  80 rIDGDKDAAMRYTETRLSKIARELFPDIDDDTVDYVPNYDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHNLREI 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 191 INGCLAYVDDEDISIegLMAHIPGPDFPTAAIINGRRGIEEAYRTGRGKVYIRARAEVEVdaksgRETIIVHEIPYQVNK 270
Cdd:pfam00521 160 IDALIALLDGPEATL--LMKYIMGPDFPTGGGIIGKGGIKEAYKTGRGKITVRAKVEIED-----RKTIVITELPYGVWT 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 271 ARLIEKIAELVKEKRVEGISALRDESDKdGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGINMVALHHGQPKIMNLKDI 350
Cdd:pfam00521 233 SDLIEKIEELVKNGKIKGISDIRDESDR-GVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGGPKYLGLKEI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 351 IAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAPTPAEAKAGLVAQawdlgnvaamleragdd 430
Cdd:pfam00521 312 LKEFLDHRLEVYERRKEYLLEKLEERLHILEGLLIALNNIDFVIEIIRGSIDRKKAKKNLIEE----------------- 374
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1737948057 431 aarpewlepefgvrdgkyyLTEQQAQAILDLRLQKLTGLEHEKLLDEYKELLEQIAELLHILGSADRLMEVIREELE 507
Cdd:pfam00521 375 -------------------LSEIQADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKLLASEKKLNDLWIEELD 432
parC_Gneg TIGR01062
DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II ...
8-716 1.50e-165

DNA topoisomerase IV, A subunit, proteobacterial; Operationally, topoisomerase IV is a type II topoisomerase required for the decatenation of chromosome segregation. Not every bacterium has both a topo II and a topo IV. The topo IV families of the Gram-positive bacteria and the Gram-negative bacteria appear not to represent a single clade among the type II topoisomerases, and are represented by separate models for this reason. [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 130134 [Multi-domain]  Cd Length: 735  Bit Score: 499.44  E-value: 1.50e-165
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   8 ITPVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDVIGKYHPHGDSAVYD 87
Cdd:TIGR01062   1 IENIDLGNFTEEAYLNYSMYVIMDRALPFIGDGLKPVQRRIVYAMSELGLNANAKYKKSARTVGDVLGKYHPHGDSACYE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  88 TIVRMAQPFSLRYMLVDGQGNFGSIDG-DSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNYDGTERIPDVMPTKIPNL 166
Cdd:TIGR01062  81 AMVLMAQPFSYRYPLVDGQGNWGAPDDpKSFAAMRYTESRLSKISELLLEELGQGTVDFRPNFDGTLLEPVILPARLPNI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 167 LVNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEGLMAHIPGPDFPTAA-IINGRRGIEEAYRTGRGKVYIRAR 245
Cdd:TIGR01062 161 LLNGTTGIAVGMATDIPPHNLHELADAALYLIDNPKAGLDDILNIVQGPDFPTEAeIIDKAEEIRKIYETGRGSFRMRAR 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 246 AEVEVDAksgretIIVHEIPYQVNKARLIEKIAELVKEKRVEGISALRDESD-KDGMRIVIEVKRDAVG-EVVLNNLYSQ 323
Cdd:TIGR01062 241 WKKEDGQ------IVISALPHQISKSKVIEQIAIQMKDKKLPMISDIRDESDhENPIRVVIVPRSNRVDpDIVMEHLFAT 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 324 TQLQVSFGINM--VALHHgQPKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANIDPIIELIRRAP 401
Cdd:TIGR01062 315 TDLEKSYRLNMnmIGLDN-VPAVKNLLEILQEWLVFRRNTVIRRLTYRLNKVLQRLHILEGLRIAFLNIDEVIEIIREED 393
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 402 TPAeakaglvaqawdlgnvAAMLERAGddaarpewlepefgvrdgkyyLTEQQAQAILDLRLQKLTGLEHEKLLDEYKEL 481
Cdd:TIGR01062 394 EPK----------------TILMERFK---------------------LSAIQAEAILNLRLRHLAKLEEHAIIDEQSEL 436
                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 482 LEQIAELLHILGSADRLMEVIREELELIRDQFGDERRT-----EITANSADInieDLINQEDVVVTLSHQGYVKYQPLTD 556
Cdd:TIGR01062 437 EKERAILEKILKSERELNQLVKKEIQADATKYGLARRSsleerEEAKQVSEI---DMIPKEPVTIILSKMGWVRSAKGHD 513
                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 557 YEAqrrggkgkSAARIKEEDFIDRLLVANTHDTILCFSSRGRLYWMKVYQLPEAsRGaRGRPIVNLLPLEADERITAILP 636
Cdd:TIGR01062 514 IDL--------STLKYKAGDSEKAIIEGKSNQKVVFIDSTGRSYALDPDNLPSA-RG-QGEPLTGKLLLPIGATITNILM 583
                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 637 VREYEEgvnVFMATASGTVKKTALTEFSRPRSAGIIAVNLNEGDELIG-VDLTSGQDEVMLFSAAGKVVRFKEDAVRAMG 715
Cdd:TIGR01062 584 YSPNQL---LLMASDAGYGFLCNFNDLIARNKAGKALINLPENASVIApLPVNGDSDMIAAITEAGRMLVFPIDDLPELS 660

                  .
gi 1737948057 716 R 716
Cdd:TIGR01062 661 K 661
PRK09631 PRK09631
DNA topoisomerase IV subunit A; Provisional
10-383 6.76e-69

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 236598 [Multi-domain]  Cd Length: 635  Bit Score: 240.77  E-value: 6.76e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  10 PVNIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLgNDWNkaYKKSARVVGDVIgKYHPHGDSAVYDTI 89
Cdd:PRK09631    1 MMDIKTLFKDNFLQYASYVIKDRAIPDVIDGLKPVQRRILHSLFEM-HDGK--FHKVANVVGNTM-KYHPHGDASIYEAL 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  90 VRMAQpfslRYMLVDGQGNFGSI-DGDSAAAMRYTEIRLAKIAHELMadLEKETVDFVDNYDGTERIPDVMPTKIPNLLV 168
Cdd:PRK09631   77 VNLAN----KDLFIDKQGNFGNLfTGDPASAARYIECRLTPLAKEVL--YNKEITEYEPSYDGRNNEPLCLPAKIPVILI 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 169 NGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEglmahipgPDFPTAAIINgrrgiEEAYRTGRGKVYIRARAEv 248
Cdd:PRK09631  151 QGAEGIAVGMATKILPHNFNEILQAVKSELLGESFALY--------PDFPTGGIVD-----VSEYADGNGKVLVRAKIE- 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 249 EVDAKsgreTIIVHEIPYQVNKARLIEKIAELVKEKRVEgISALRDESdKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQV 328
Cdd:PRK09631  217 TKDEK----TIVIREIPFGTTTESLIASIEKAARKGKIK-ISSINDYT-AENVEIEIKLPRGVYASEVIEALYAYTDCEV 290
                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1737948057 329 SFGINMVALHHGQPKIMNLKDIIAAFVRHRREVVTRRtiFELrkarDRAHILEAL 383
Cdd:PRK09631  291 SISVNLLVIKDRYPVIYTVTDIIKFHAEHLQKVLKME--LEL----ERAKLLEKI 339
PRK12758 PRK12758
DNA gyrase/topoisomerase IV subunit A;
18-329 4.24e-54

DNA gyrase/topoisomerase IV subunit A;


Pssm-ID: 237192 [Multi-domain]  Cd Length: 869  Bit Score: 202.54  E-value: 4.24e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  18 KNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDwnkAYKKSARVVGDVIgKYHPHGDSAVYDTIVRMAQpfs 97
Cdd:PRK12758   28 KNWFLDYASYVILERAVPHIEDGLKPVQRRILHSMKEMDDG---RYNKVANVVGHTM-QYHPHGDASIGDALVQLGQ--- 100
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  98 lRYMLVDGQGNFGSI-DGDSAAAMRYTEIRLAKIAHELMadLEKETVDFVDNYDGTERIPDVMPTKIPNLLVNGASGIAV 176
Cdd:PRK12758  101 -KDLLIDTQGNWGNIlTGDGAAAPRYIEARLSKFALEVV--FNPKTTEWQLSYDGRKKEPVTLPVKFPLLLAQGAEGIAV 177
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 177 GMATNIPPHNLTEVINGCLAYVDDEDISIEglmahipgPDFPTAAIIN------GRRGieeayrtgrGKVYIRARAEvEV 250
Cdd:PRK12758  178 GLSTKILPHNFNELIDASIAYLKGKEFKLY--------PDFPTGGIIDvsnyndGERG---------GRVRVRAKIE-KL 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 251 DAKsgreTIIVHEIPYQVNKARLIEKIAEL-----VKEKRVEGISAlrdesdkDGMRIVIEVKRDAVGEVVLNNLYSQTQ 325
Cdd:PRK12758  240 DKK----TLVITEIPYGTTTSSLIDSILKAndkgkIKIKKVEDNTA-------ADVEILVHLAPGVSPDKTIDALYAFTD 308

                  ....
gi 1737948057 326 LQVS 329
Cdd:PRK12758  309 CEVS 312
PRK09630 PRK09630
DNA topoisomerase IV subunit A; Provisional
12-351 1.77e-46

DNA topoisomerase IV subunit A; Provisional


Pssm-ID: 170022  Cd Length: 479  Bit Score: 173.54  E-value: 1.77e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  12 NIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLgnDWNKAYKksarvVGDVIGK---YHPHGDSAVYDT 88
Cdd:PRK09630    3 DVSDLFKTHFMHYASYVILERAIPHILDGLKPVQRRLLWTLFRM--DDGKMHK-----VANIAGRtmaLHPHGDAPIVEA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  89 IVRMAQpfslRYMLVDGQGNFGS-IDGDSAAAMRYTEIRLAKIAHELMadLEKETVDFVDNYDGTERIPDVMPTKIPNLL 167
Cdd:PRK09630   76 LVVLAN----KGYLIDTQGNFGNpLTGDPHAAARYIEARLSPLAKEVL--FNTDLMTFHDSYDGREKEPDILPAKLPLLL 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 168 VNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISIEglmahipgPDFPTAAIINGrrgieEAYRTGRGKVYIRARAE 247
Cdd:PRK09630  150 LHGVDGIAVGMTTKIFPHNFCELLEAQIAILNDQPFTLL--------PDFPSGGTMDA-----SEYQDGLGSITLRASID 216
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 248 VeVDAKsgreTIIVHEIPYQVNKARLIEKIAELVKEKRVEgISALRDESdKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQ 327
Cdd:PRK09630  217 I-INDK----TLLIKEICPSTTTETLIRSIENAAKRGIIK-IDSIQDFS-TDLPHIEIKLPKGIYAKDLLRPLFTHTECQ 289
                         330       340
                  ....*....|....*....|....
gi 1737948057 328 VSFGINMVALHHGQPKIMNLKDII 351
Cdd:PRK09630  290 VILTSRPTAIYQNKPVETSISEIL 313
52 PHA02592
DNA topisomerase II medium subunit; Provisional
12-390 6.13e-43

DNA topisomerase II medium subunit; Provisional


Pssm-ID: 222896 [Multi-domain]  Cd Length: 439  Bit Score: 162.15  E-value: 6.13e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  12 NIEEELKNSYLDYAMSVIVGRALPDVRDGLKPVHRRVLYAMNVLGNDWNKAYKKSARVVGDV--IGkYHpHGDSAVYDTI 89
Cdd:PHA02592    7 SLKSIVNNEALEYAMYTVEERAIPNLIDGLKPVQRFVIHRALEYAKGNKEKFDKVAAIAGGVadLG-YH-HGETSAQDAG 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  90 VRMAQPFSLRYMLVDGQGNFGSIDGDSAAAMRYTEIRLakiaHELMADLEKETvDFVDNYDGTERIPDV--MPTkIPNLL 167
Cdd:PHA02592   85 ALMANTWNNNIPLLDGQGNFGSRLVQKAAAARYIFARV----HDNFRKIYKDE-DLAPVHEDPEHIPPAfyLPI-IPMVL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 168 VNGASGIAVGMATNIPPHNLTEVINGCLAYVDDEDISieglmahIPGPDFPtaaiinGRRGieEAYRTGRGKVYIRARAE 247
Cdd:PHA02592  159 LNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDIT-------EPKVQFP------EFKG--EVVEIEPGSYEIRGTYE 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057 248 VevdakSGRETIIVHEIPYQVNKARLIEKIAELVKEKRVEGIsalrDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQ 327
Cdd:PHA02592  224 L-----NGKTKLHITEIPVKYDRETYVAVLDPLEEKGKIVSY----DDCTEDGFRFKVTLKREENEEATHEKIMKDFGLI 294
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1737948057 328 VSFGINMVALH-HGQPKIM-NLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEALAVALANI 390
Cdd:PHA02592  295 ERVSQNITVINeNGKLKVYeNAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRV 359
PTZ00108 PTZ00108
DNA topoisomerase 2-like protein; Provisional
32-523 3.16e-25

DNA topoisomerase 2-like protein; Provisional


Pssm-ID: 240271 [Multi-domain]  Cd Length: 1388  Bit Score: 113.22  E-value: 3.16e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   32 RALPDVRDGLKPVHRRVLYAMnvlgndWNKAYKKSARVV---GDVIGK--YHpHGDSAVYDTIVRMAQPF----SLRYML 102
Cdd:PTZ00108   680 RSIPSLVDGLKPGQRKILFAC------FKRNLKNEIKVAqlsGYVSEHsaYH-HGEQSLQQTIVGMAQNFvgsnNINLLY 752
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  103 VDGQgnFGS--IDGDSAAAMRYTEIRLAKIA----HElmADleketvDFVDNY---DGTERIPD-VMPTkIPNLLVNGAS 172
Cdd:PTZ00108   753 PCGQ--FGSrlQGGKDHAAARYIFTKLSKITryifPE--ED------DPILDYledDGQSVEPFyYVPI-IPMVLVNGAE 821
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  173 GIAVGMATNIPPHNLTEVingclayvddedisIEGLMAHIPGPDFPTaaiingrrgIEEAYRTGRGKvyIRARAEVEVDA 252
Cdd:PTZ00108   822 GIGTGFSTSIPNYNPLDI--------------IDNLRRRLNGEEVRP---------LVPWYRGFKGT--IERNPKGKFIS 876
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  253 KS-----GRETIIVHEIPYQVNKARLIEKIAELVKEKRvEGISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQ 327
Cdd:PTZ00108   877 KGiyekvPDGTVEITELPIGKWTEDYKEFLESETLKEK-DVIVDYRDYSTANTVHFTVKLNDGVLEQWEEEGIEKVFKLK 955
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  328 VSFGI-NMVALHHGQ--PKIMNLKDIIAAFVRHRREVVTRRTIFELRKARDRAHILEA-----LAVALANIDpiielIRR 399
Cdd:PTZ00108   956 STISTtNMVLFDENGkiKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNkvrfiKHVINGELV-----ITN 1030
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  400 APtpaeaKAGLVAQAWDLG---------------NVAAMLERAGDDAARPEWLEPEFGVRDGKYYLteqqaqaiLDLRLQ 464
Cdd:PTZ00108  1031 AK-----KKDLVKELKKLGyvrfkdiikkksekiTAEEEEGAEEDDEADDEDDEEELGAAVSYDYL--------LSMPIW 1097
                          490       500       510       520       530       540
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1737948057  465 KLTgLEH-EKLLDEYKELLEQIAELLHIlgsadrlmEVI---REELELIRDQFGDERRTEITA 523
Cdd:PTZ00108  1098 SLT-KEKvEKLNAELEKKEKELEKLKNT--------TPKdmwLEDLDKFEEALEEQEEVEEKE 1151
PLN03128 PLN03128
DNA topoisomerase 2; Provisional
32-483 1.17e-24

DNA topoisomerase 2; Provisional


Pssm-ID: 215593 [Multi-domain]  Cd Length: 1135  Bit Score: 110.95  E-value: 1.17e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   32 RALPDVRDGLKPVHRRVLYAmnVLGNDWnKAYKKSARVVGDVI--GKYHpHGDSAVYDTIVRMAQPF--SLRYMLVDGQG 107
Cdd:PLN03128   673 RSIPSMVDGLKPSQRKVLFA--CFKRNL-KSEIKVAQLSGYVAehSAYH-HGEASLASTIIGMAQDFvgSNNINLLTPSG 748
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  108 NFGS--IDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNyDGTERIPD-VMPTkIPNLLVNGASGIAVGMATNIPP 184
Cdd:PLN03128   749 QFGTrlQGGKDAASARYIFTRLSPITRALFPKDDDVLLNYLNE-DGQSIEPEwYCPI-IPMVLVNGSEGIGTGWSTFIPN 826
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  185 HNLTEVINGCLAYVDDEDisieglmahiPGPDFPTAAIINGRrgIEEAYRTGRGKVYIRARAEvevdaKSGRETIIVHEI 264
Cdd:PLN03128   827 YNPRDIIANIRRLLRGEE----------LEPMHPWYRGFKGT--ITEVSTSRSGSYTVTGIIE-----QIGDTTIRITEL 889
                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  265 PYQV---NKARLIEKIAELVKEKRVEgISALRDESDKDGMRIVIEVKRDAVGEVVLNNLYSQTQLQVSFGI-NMVALHH- 339
Cdd:PLN03128   890 PVRKwtqDYKEFLEALLTGTKKKEPE-IKDFKENHTDTTVHFTVTLSEEKMARALAEGLEKKFKLSTTISTsNMHLFDKd 968
                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  340 GQPKIMNL-KDIIAAFVRHR-------REVVTRRTIFELRKARDRAH-ILEALAVAL-------ANIDPIIELIRRAPTP 403
Cdd:PLN03128   969 GKIKKYDSpEDILEEFFHLRldlyvkrKEVLLENLEYELKKLDNKARfILAVVKGEIvvnnrkrAELLAELEEKGFDKFP 1048
                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  404 AEAKAGLVAQAWDLGNVAAMLERAGDDAARPEWlepEFGVRDGKYYLTEQQAQAILDLR---------LQKLTGLEH-EK 473
Cdd:PLN03128  1049 KTAKISETNVVGDRDGEASEEEEASDNELAKSY---DYLLGMPISSLTLEKVDELRAERakketeveeLKKTTPEDLwRK 1125
                          490
                   ....*....|
gi 1737948057  474 LLDEYKELLE 483
Cdd:PLN03128  1126 DLDAFEEALD 1135
PLN03237 PLN03237
DNA topoisomerase 2; Provisional
32-201 3.48e-14

DNA topoisomerase 2; Provisional


Pssm-ID: 215641 [Multi-domain]  Cd Length: 1465  Bit Score: 77.21  E-value: 3.48e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057   32 RALPDVRDGLKPVHRRVLYAmnvlgnDWNKAYKKSARV---VGDV--IGKYHpHGDSAVYDTIVRMAQPF----SLRYML 102
Cdd:PLN03237   698 RSIPSMVDGLKPGQRKILFC------SFKRNFVKEAKVaqlSGYVseHSAYH-HGEQSLASTIIGMAQDFvgsnNINLLL 770
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1737948057  103 VDGQGNFGSIDGDSAAAMRYTEIRLAKIAHELMADLEKETVDFVDNyDGTERIPD-VMPTkIPNLLVNGASGIAVGMATN 181
Cdd:PLN03237   771 PNGQFGTRLQGGKDHASARYIFTRLSPITRFLFPKDDDILLDYLNE-DGQSIEPTwYMPI-IPTVLVNGAEGIGTGWSTF 848
                          170       180
                   ....*....|....*....|
gi 1737948057  182 IPPHNLTEVINGCLAYVDDE 201
Cdd:PLN03237   849 IPNYNPRDIVANIRRLLNGE 868
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
692-737 6.35e-13

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 63.66  E-value: 6.35e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1737948057 692 DEVMLFSAAGKVVRFKEDAVRAMGRTATGVRGIKLAENDSVVSLII 737
Cdd:pfam03989   1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGINLKEGDKVVSVLV 46
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
793-839 9.27e-11

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 57.50  E-value: 9.27e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1737948057 793 DQIMMITDAGTLVRTRVSEVSIVGRNTQGVILIRTAEDENVVGLQRV 839
Cdd:pfam03989   1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGINLKEGDKVVSVLVV 47
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
744-790 5.48e-09

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 52.49  E-value: 5.48e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1737948057 744 ILTVTQNGYGKRTAAAEYPTKSRATQGVISIKVTErNGSVVGAVQVD 790
Cdd:pfam03989   3 LLLITSKGYVKRTPLSEIREQGRGAKGVKGINLKE-GDKVVSVLVVN 48
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
588-638 7.07e-09

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 52.10  E-value: 7.07e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1737948057 588 DTILCFSSRGRLYWMKVYQLPEASRGARGRPIVNllpLEADERITAILPVR 638
Cdd:pfam03989   1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGIN---LKEGDKVVSVLVVN 48
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
538-585 1.01e-08

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 51.72  E-value: 1.01e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1737948057 538 DVVVTLSHQGYVKYQPLTDYEAQRRGGKGKSAARIKEEDFIDRLLVAN 585
Cdd:pfam03989   1 DELLLITSKGYVKRTPLSEIREQGRGAKGVKGINLKEGDKVVSVLVVN 48
DNA_gyraseA_C pfam03989
DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the ...
645-689 4.57e-06

DNA gyrase C-terminal domain, beta-propeller; This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC DNA gyrases. It is predicted to form 4 beta strands and to probably form a beta-propeller structure. This region has been shown to bind DNA non-specifically and may stabilize the DNA-topoisomerase complex.


Pssm-ID: 427633 [Multi-domain]  Cd Length: 48  Bit Score: 44.40  E-value: 4.57e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 1737948057 645 NVFMATASGTVKKTALTEFSRPR--SAGIIAVNLNEGDELIGVDLTS 689
Cdd:pfam03989   2 ELLLITSKGYVKRTPLSEIREQGrgAKGVKGINLKEGDKVVSVLVVN 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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